A freeze dryer double door and its feeding and suction system
Through the freeze-dryer two doors and the suction system, the material isolation and absorption protection of freeze-drying products in the freeze-dryer are achieved, and the problem of insufficient material isolation during the discharge process of the existing freeze-dryer is solved, and the product quality is improved and applicable to the hygiene needs of the food and drug industry.
Patent Information
- Application Number
- CN202211197164.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-09-29
- Publication Date
- 2025-08-19
- Estimated Expiration
- 2042-09-29
AI Technical Summary
The existing freeze-dryers cannot achieve complete isolation between the material and the external environment during the discharge process, especially for anaerobic and moisture-absorbing products such as probiotic freeze-dried powder, which cannot be protected by inert gas, affecting product quality.
A freeze-dryer two-way door and its material suction system are designed, including a flexible cover and baffle, equipped with a material suction gun and a crushing and encapsulation integrated machine, and the CIP cleaning and SIP steam sterilization function of the freeze-dryer is used to achieve isolation between materials and environment and absorption protection.
In a closed state, the freeze-dried product is taken out, crushed and packaged to meet the requirements of absorption and water insulation, realize the sterile needs, and adapt to the existing freeze-dried machine for small modification and easy implementation.
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Figure CN115535394B_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the field of freeze dryer equipment, in particular to a freeze dryer double door and a material feeding and suction system thereof. Background Art
[0002] A vacuum freeze dryer (freeze dryer for short) generally consists of a freeze-drying chamber with a plate assembly, on which the product to be freeze-dried is placed. Its function is to pre-freeze the freeze-dryable aqueous substance or solution at a low temperature, then dehydrate the substance under a vacuum environment to obtain the dried product before discharging.
[0003] Taking the discharge of probiotic freeze-dried powder as an example, there are currently two main methods for discharging. One method is to place the product on a tray before freeze-drying, manually remove it from the tray after freeze-drying is complete, and then pour the product from the tray into a container. The other method is to place the product directly on the tray and transfer the freeze-dried powder to the container manually or using suction equipment after freeze-drying is complete. Currently, this process has not yet achieved complete isolation of the material from the external environment, so inert gas cannot be used to protect the discharge process of the freeze-drying chamber. Therefore, for anaerobic and hygroscopic products such as probiotic freeze-dried powder, completely isolating the product from the external environment and protecting it with high-purity and extremely low-water-content nitrogen will greatly improve product quality. Summary of the Invention
[0004] The technical task of the present invention is to address the deficiencies of the above-mentioned existing technologies and provide a freeze dryer double door and its material intake and intake system, which can be used for sterile chemically sensitive materials to achieve complete isolation and anaerobic protection of the materials from the environment during the freeze-drying and material collection process, while also meeting the hygiene requirements of the food and pharmaceutical industries.
[0005] The technical solution adopted by the present invention to solve its technical problems is: a freeze dryer with two doors, the freeze dryer including a freeze drying chamber and a freeze drying chamber door matching the freeze drying chamber, two doors are arranged on the door frame at the entrance of the freeze drying chamber, the two doors include a flexible cover and a baffle, the baffle is arranged at the entrance of the freeze drying chamber, and its edge is sealed to the door frame through the flexible cover; a sliding sealing assembly is provided in the middle of the baffle, and the sliding sealing assembly matches the suction pipe of the suction gun.
[0006] Furthermore, a connecting valve is provided in the door frame, and the connecting valve is used to balance the pressure on both sides of the two doors between the freeze-drying chamber and the freeze-drying chamber door.
[0007] A freeze dryer feeding and suction system comprises the above-mentioned two doors, a suction gun and a suction, crushing and encapsulating integrated machine; the door frame is provided with a suction gun discharge port; the suction gun comprises a suction head and a suction tube, the suction head is an unpowered or self-powered suction device, used to cut, crush and collect the freeze-dried products into the suction tube, the suction tube consists of two parts, one is a hard tube, and the other is a soft tube; one end of the hard tube passes through the sliding sealing assembly on the baffle and is connected to the suction head, and the other end is outside the baffle and is connected to one end of the soft tube, and the other end of the soft tube is connected to the suction gun discharge port; the suction gun discharge port is connected to the suction, crushing and encapsulating integrated machine.
[0008] Furthermore, the freeze dryer is a freeze dryer with CIP cleaning and SIP steam sterilization functions. The door frame is provided with a CIP inlet, a feed pipe, and an air return port connected to the freeze drying bin. The CIP inlet is connected to the spray head in the bin, and the feed pipe is connected to the liquid distribution station of the freeze-dried product outside the bin, which is used to add the liquid of the freeze-dried product to the surface of the plate layer in the bin; the air return port is used to replenish gas for the bin body; except for the connecting valve, the suction gun discharge port, the air return port, the feed pipe, the CIP inlet and the external seal are static seals and can be kept intact during the entire production process.
[0009] Furthermore, the door frame is provided with two door spray pipes connected to the CIP inlet, and the two door spray pipes are provided with spray heads.
[0010] Furthermore, the length of the suction tube depends on whether the suction head can reach the innermost part of the plate layer in the freeze-drying chamber when the baffle is near the door end, and when the hard tube and the suction head are placed in the freeze-drying chamber, the freeze-drying chamber door can be closed.
[0011] Furthermore, the feeding and suction system also includes a four-axis robot; the four-axis robot is connected to the suction gun and the baffle, and is used to realize the linear movement of the suction head and the baffle in the front and back, left and right, and up and down directions and the linear movement between the baffle and the suction head.
[0012] Furthermore, the four-axis robot includes a linear guide rail, a vertical support, a vertical slide rail, a transverse slide rail, a transverse support, a longitudinal slide rail, and a longitudinal support; a longitudinal slide rail is slidably provided on the longitudinal support, a vertical support is provided on the longitudinal slide rail, a vertical slide rail is slidably provided on the vertical support, a transverse slide rail is provided on the vertical slide rail, a transverse support is slidably installed on the transverse slide rail, one end of the transverse support is connected to the baffle, a linear guide rail is also slidably provided on the transverse support, and the linear guide rail is connected to the suction pipe hard tube.
[0013] Furthermore, the material suction, crushing and encapsulation integrated machine includes a completely sealed vacuum suction machine, a completely sealed crusher, and a material discharge and packaging mechanism connected in sequence; the suction port of the vacuum suction machine is connected to the discharge port of the suction gun, which is used to suck the material in the freeze-drying bin and perform gas-solid separation, and the separated solid phase material enters the crusher for crushing; the material discharge and packaging mechanism is used to package and seal the crushed material.
[0014] Furthermore, the material suction, crushing and encapsulation integrated machine also includes a gas circulation system with a filtering function, including a vortex fan and a filter connected to it; the vortex fan is connected to the vacuum suction machine, and the filter is connected to the air return port of the freeze-drying bin; the vortex fan provides suction power for the vacuum suction machine, and the filter finely filters the sucked-out gas and replenishes it to the freeze-drying bin to realize a closed-loop circulation of the gas during the suction process.
[0015] Compared with the prior art, the present invention has the following beneficial effects:
[0016] The present invention allows freeze-dried products to be removed from the freeze-drying chamber through a material pipeline, crushed into powder, and packaged in a completely sealed state, completely isolating the product from the environment. This not only meets the requirements of oxygen and water isolation, but also meets the sterility requirements of the system through CIP cleaning and SIP steam sterilization functions. Furthermore, the system can be adapted to existing freeze dryers, requiring minimal modification and easy implementation, thus facilitating the widespread adoption of this suction system.
[0017] The system of the present invention can sterilize the second door, the suction gun and the feed pipe with the help of the SIP steam sterilization function of the freeze dryer. After the freeze dryer is vacuumed, inert (clean) gas is added to realize oxygen-freezing in the warehouse. After feeding through the pipeline and completing freeze drying, the freeze-dried product is sucked into the freeze-drying warehouse, crushed and encapsulated in a sealed bag by using the sealing system composed of the freeze-drying warehouse, the suction gun and the crushing and encapsulating integrated machine. During this period, the gas sucked from the freeze-drying warehouse by the suction gun is separated from the gas and powder and filtered before being replenished into the freeze-drying warehouse to realize closed-loop circulation. After the suction is completed, the suction gun is separated from the second door, and the suction gun and the crushing and encapsulating integrated machine are CIP cleaned together. The flexible cover of the second door is CIP cleaned together with the freeze-drying warehouse. Finally, the freeze-dried product is completely isolated from the outside world and oxygen, and the CIP and SIP of the equipment are completed online. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] Figure 1 It is a schematic diagram of the structure of the second door and the material feeding and suction system as well as the system workflow.
[0019] Figure 2 This is a schematic diagram of the SIP steam sterilization and material feeding and suction process of the second door, suction gun and freeze-drying chamber;
[0020] Figure 3 This is a schematic diagram of the cleaning process of the freeze-drying chamber, the second door and the suction system after the suction and crushing is completed;
[0021] Figure 4 This is a schematic diagram of the structure of the suction, crushing and encapsulation integrated machine and its SIP steam sterilization and CIP cleaning process;
[0022] Figure 5 for Figure 1 、 3 A magnified view of middle A;
[0023] Figure 6 for Figure 1 、 2 , 3B enlarged view;
[0024] Figure 7 for Figure 1 、 2 , an enlarged view of C in 3;
[0025] Reference numerals:
[0026] 1-freeze-drying chamber; 2-plate layer; 3-suction head; 4-return air port; 5-pressure-resistant door frame; 6-suction gun discharge port; 7-flexible cover; 8-suction pipe; 9-freeze-drying chamber door; 10-linear guide rail; 11-vertical support; 12-vertical slide rail; 13-horizontal slide rail; 14-horizontal support; 15-four-axis robot; 16-longitudinal slide rail; 17-longitudinal support; 18-drainage port; 19-connecting frame; 20-sealed valve; 21-sliding seal assembly; 22-connecting valve; 23-feeding pipe ;24-Material inlet;25-Distribution station;26-Spray head;27-CIP inlet;28-Air outlet;29-Suction port;30-Pulverizer;31-Butterfly valve;32-Vortex fan;33-Filter;34-Inert gas inlet;35-Vacuum port;36-Packaging material;37-Sealer;38-Discharge port;39-Liquid collecting hopper;40-Drainage port;41-Stirring paddle;42-Screen;43-Baffle;44-Adapter;45-Bottom hopper;46-Vacuum suction machine. DETAILED DESCRIPTION
[0027] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.
[0028] Example 1
[0029] like Figures 1 to 7As shown, a freeze dryer with two doors includes a freeze drying chamber 1 and a freeze drying chamber door 9 matched with the freeze drying chamber. Two doors are arranged on the pressure-resistant door frame 5 at the entrance of the freeze drying chamber. The two doors include a flexible cover 7 and a baffle 43. The baffle is arranged at the entrance of the freeze drying chamber, and its edge is sealed to the door frame through the flexible cover; a sliding sealing assembly 21 is provided in the middle of the baffle, and the sliding sealing assembly matches the suction pipe 8 of the suction gun.
[0030] Among them, a connecting valve 22 is provided in the door frame. When the freeze-drying chamber door is opened, the valve is closed to achieve sealing inside the freeze-drying chamber. When the freeze-drying chamber door is closed, the valve is opened to achieve internal and external pressure balance on both sides of the two doors between the freeze-drying chamber and the freeze-drying chamber door during the vacuum extraction process.
[0031] The baffle is made of a lightweight, transparent material with a certain strength, heat resistance (>125°C), cold resistance (<-50°C), acid and alkali resistance, and food and pharmaceutical grade. It is preferably made of pharmaceutical-grade engineering plastics such as polyphenylene ether (PPO) or modified polyphenylene ether (MPPO). The sliding seal assembly on the baffle allows the suction tube to extend and retract freely while maintaining a tight seal. The sealing surface is preferably a self-lubricating lip seal. Axial positioning of the suction tube is performed outside the lip seal (outside the freeze-drying chamber), preferably using a linear bearing.
[0032] The flexible cover is made of a flexible film with a certain strength that is heat-resistant (>125°C), cold-resistant (<-50°C), acid- and alkali-resistant, and meets food and pharmaceutical grade standards. The preferred material is silicone rubber or fluorosilicone rubber. The inner lining is made of a cloth to maintain its strength. The cloth is preferably made of fiberglass or nylon. The size of the cover is determined by the position of the baffle near the door that can reach the four corners of the freeze-drying chamber door.
[0033] Example 2
[0034] like Figures 1 to 7 As shown, a freeze dryer feeding and suction system includes the two doors, suction gun and suction, crushing and encapsulation integrated machine described in Example 1; the door frame is provided with a suction gun discharge port 6; the suction gun includes a suction head 3 and a suction tube 8, the suction head is an unpowered or self-powered suction device, which is used to cut, crush and collect the freeze-dried products into the suction tube, and the suction tube consists of two parts, one part is a hard tube, and the other part is a soft tube; one end of the hard tube passes through the sliding sealing assembly on the baffle and is connected to the suction head, and the other end is outside the baffle and is connected to one end of the soft tube, and the other end of the soft tube is connected to the suction gun discharge port; the suction gun discharge port is connected to the suction, crushing and encapsulation integrated machine.
[0035] Among them, the freeze dryer is a freeze dryer with CIP cleaning and SIP steam sterilization functions. The door frame is provided with a CIP inlet 27 connected to the freeze drying bin, a feed pipe 23, and a return air port 4. The CIP inlet is connected to the spray head 26 in the bin, and the feed pipe is connected to the liquid distribution station 25 for the freeze-dried product outside the bin, which is used to add the liquid of the freeze-dried product to the surface of the plate layer 2 in the bin; the return air port is used to replenish gas for the bin body; except for the connecting valve, the suction gun discharge port, return air port, feed pipe, CIP inlet and the external seal are static seals and can be kept intact during the entire production process.
[0036] Wherein, the door frame is provided with two door spray pipes connected to the CIP inlet, and the two door spray pipes are provided with spray heads ( Figure 3 ).
[0037] Among them, the length of the suction pipe hard tube depends on whether the suction head can reach the innermost part of the plate layer in the freeze-drying chamber when the baffle is near the door end, and when the hard tube and the suction head are placed in the freeze-drying chamber, the freeze-drying chamber door can be closed.
[0038] Among them, the feeding and suction system also includes a four-axis robot; the four-axis robot is connected to the suction gun and the baffle, and is used to realize the linear movement of the suction head and the baffle in the front and back, left and right, and up and down directions and the linear movement between the baffle and the suction head.
[0039] Among them, the four-axis robot 15 includes a linear guide rail, a vertical support, a vertical slide rail, a transverse slide rail, a transverse support, a longitudinal slide rail, and a longitudinal support; a longitudinal slide rail 16 is slidably provided on the longitudinal support 17, a vertical support 11 is provided on the longitudinal slide rail, a vertical slide rail 12 is slidably provided on the vertical support, a transverse slide rail 13 is provided on the vertical slide rail, a transverse support 14 is slidably installed on the transverse slide rail, one end of the transverse support is connected to the baffle 43, and a linear guide rail 10 is also slidably provided on the transverse support, and the linear guide rail is connected to the suction pipe hard tube.
[0040] The four-axis robot enables linear motion of the suction head and baffle in forward, backward, left, right, and vertical directions, as well as linear motion between the baffle and the suction head. This allows the baffle to be moved from the far end to the near-door end. The suction head, aided by the baffle's vertical and horizontal motion, then moves back and forth along the guide rails to completely absorb all products from the sheet. The connections between the suction pipe 8 and the linear guide rail 10, and between the baffle 43 and the transverse support 14, are quick-plug connections, ensuring automatic connection and disconnection between the transverse support 14 and the linear guide rail 10.
[0041] Wherein, a connecting frame 19 is provided on the baffle plate for connecting it with the four-axis robot, so as to realize the displacement of the baffle plate in three degrees of freedom: horizontal, vertical and front and back. If the baffle plate is moved by manpower, the connecting frame is the handle.
[0042] Among them, the material suction, crushing and encapsulation integrated machine includes a completely sealed vacuum suction machine 46, a completely sealed crusher 30, and a material discharge and packaging mechanism (31, 34, 35, 36, 37) connected in sequence; the suction port 29 of the vacuum suction machine 46 is connected to the discharge port 6 of the suction gun, which is used to suck the material in the freeze-drying bin and perform gas-solid separation. The separated solid phase material enters the crusher 30 for crushing; the material discharge and packaging mechanism is used to package and seal the crushed material.
[0043] Among them, the material suction, crushing and encapsulation integrated machine also includes a gas circulation system with a filtering function, including a fully enclosed vortex fan 32 and a filter 33 connected to it; the vortex fan is connected to the air outlet 28 of the vacuum suction machine, and the filter is connected to the air return port of the freeze-drying bin; the vortex fan provides suction power for the vacuum suction machine, and the filter finely filters the sucked-out gas and replenishes it to the freeze-drying bin to realize a closed-loop circulation of the gas during the suction process.
[0044] Among them, the vacuum suction machine is a fully sealed structure, with only the suction port 29, the air outlet 28 and the discharge port 38 connected to the external mechanism. A filter element (titanium rod) is provided inside to separate the material and the gas.
[0045] Among them, the crusher is mainly composed of a stirring paddle 41, a screen 42, and a bottom hopper 45. After the material is fed into the crusher through a vacuum suction machine, the high-speed rotating stirring paddle can squeeze and rub the material in the screen until it is crushed into small particles, which fall from the screen into the bottom hopper.
[0046] Among them, the unloading and packaging mechanism is mainly composed of an adapter 44, a packaging material 36, and a sealer 37. The adapter is provided with a vacuum port 35 and an air inlet 34, which can realize the functions of exhausting and replenishing air for the packaging material; the sealer 37 can realize the sealing of the packaging material after the unloading is completed.
[0047] A. Based on the above-mentioned feeding and suction system, the system's SIP steam sterilization, feeding and freeze-drying process is as follows:
[0048] like Figure 2 As shown, the suction head 3 on the suction gun and the hard tube part on the suction pipe 8 are placed in the freeze-drying bin 1, and the soft part of the suction pipe 8 is placed between the second door flexible cover 7 and the freeze-drying bin door 9. Since the bin door 9 is in a closed state, the connecting valve 22 is in an open state, and the air pressure on both sides of the two doors is balanced.
[0049] Steam can enter the freeze-drying chamber through the CIP inlet 27, the freeze-drying chamber return air port 4, the suction gun discharge port 6, the feeding distribution station 25 connected to the feeding pipe, or the freeze-drying machine's own inlet, and flow out through the sewage outlet 18. When the steam enters the freeze-drying chamber 1 and the pressure rises to above 0.1Mpa and the temperature is greater than 121°C, it is maintained for 30 minutes, and SIP sterilization is completed.
[0050] After sterilization is complete, the system is evacuated to remove saturated water vapor and replenished with nitrogen to normal pressure (or slightly positive pressure). Once the temperature drops to room temperature, the freeze-dried raw material liquid is quantitatively added to each plate layer 2 to a specified volume using the dispensing station 25. The freeze-dried raw material is then plated under the protection of nitrogen. The plates are then cooled for pre-freezing, and after a certain pre-freezing period, vacuum drying is performed.
[0051] B. Based on the above-mentioned feeding and suction system, the process of collecting, crushing and bagging the materials after freeze-drying is as follows:
[0052] like Figure 1 As shown, after vacuum drying is complete, nitrogen is added to freeze-drying chamber 1 to atmospheric pressure (slightly positive pressure), and freeze-drying chamber door 9 is opened. Connecting valve 22 is now closed, and freeze-drying chamber 1 is isolated from the outside air by a double door consisting of a pressure-resistant door frame 5, a flexible cover 7, and a baffle 43. At this point, a four-axis robot 15, connected to the suction pipe 8 and baffle 43 via linear guides 10 and transverse supports 14, removes the suction head 3 from the freeze-drying chamber, and begins collecting the material from each plate layer 2. Manual collection of the material from the plate layers can also be performed in this process.
[0053] During the collection process, the suction port 29 of the vacuum suction machine 46 is connected to the discharge port 6 of the second-door suction gun. After the material is sucked into the vacuum suction machine, gas and powder separation is achieved under the action of the filter element. The separated gas is sucked into the completely sealed vortex fan 32 from the outlet 28 and is finely filtered through the filter 33 before re-entering the freeze-drying chamber through the return air port 4 to achieve internal gas balance during the suction process.
[0054] After the material is fed into the pulverizer 30 by the vacuum suction machine 46 , the high-speed rotating stirring paddle 41 squeezes and rubs the material in the screen 42 until it is crushed into small particles, which fall from the screen 42 into the bottom hopper 45 .
[0055] A butterfly valve 31 is located at the bottom of the hopper, connected to an adapter 44, whose lower portion is connected to pre-sterilized packaging material 36. Before pouring the material from hopper 45 into the packaging material, the vacuum port 35 on adapter 44 is opened to expel the air from the packaging material. The inert gas inlet 34 is then opened to expand the packaging material. At this point, the butterfly valve 31 is opened and the material is poured into the packaging material. The vacuum port 35 can also be opened to remove air from the powder, and the packaging material is then sealed with a sealer 37. This effectively isolates the material from the environment throughout the entire freeze-drying, storage, pulverization, and packaging process.
[0056] C. Based on the above suction system, the CIP cleaning process of the freeze drying chamber, the second door and the suction system is as follows:
[0057] like Figure 3As shown, after the material is sucked in, the plate layer 2 tilts to the point where the liquid on the top can be drained by itself. The freeze-drying chamber can communicate with the outside world through the return air port 4. The four-axis robot 15 pulls out the baffle 43, allowing the flexible cover 7 to be fully deployed, leaving no blind spots for cleaning. At the same time, the sliding linear guide 10 pushes the suction pipe 8 into the cavity formed by the flexible cover 7 to rinse the suction pipe. At this time, the CIP cleaning system is turned on. It has two CIP liquid inlets: one enters from the suction gun discharge port 6 to clean the suction pipe 8 and the suction head 3, and the other enters from the CIP inlet 27. This inlet is connected to the pre-set spray head 26 in the freeze-drying chamber to achieve comprehensive cleaning of the freeze-drying chamber 1, the plate layer 2, the flexible cover 7, the suction head 3, the outer wall of the suction pipe 8, and the partition 43. The cleaning liquid is discharged from the drain port 18. The cleaning procedure is: clean with domestic water for 15 minutes, then change to 1-3% NaOH solution at 50-70℃ for 15 minutes, then change to pure water for transient cleaning until the conductivity of the effluent is the same as that of pure water. Figure 1 .The state is used to carry out sterilization, loading and freeze-drying of the next batch.
[0058] D. Based on the above-mentioned material intake and suction system, the SIP sterilization and CIP cleaning of the system material intake, crushing and encapsulation integrated machine are as follows:
[0059] SIP sterilization Figure 4 As shown:
[0060] After the packaging material is removed from the bottom of the adapter 44, it is connected to the liquid collecting hopper 39 and sealed. There is a drain port 40 at the bottom of the liquid collecting hopper 39. Steam enters the vacuum suction machine 46 from the air outlet 28, a part of it is discharged through the suction port 29, and the other part enters the crusher 30, and enters the adapter 44 through the open butterfly valve 31 and is finally discharged from the vacuum port 35, the inert gas inlet 34 and the drain port 40 on the liquid collecting hopper 39, finally achieving dead-angle sterilization of the system. The preferred SIP sterilization strategy is: synchronized with the SIP sterilization of the freeze-drying chamber. When the system temperature is >121°C and the pressure is greater than 0.1Mpa, it is maintained for 20 to 30 minutes. After the sterilization is completed, the other external interfaces are closed, and only the suction port is connected to the freeze-drying chamber. During the vacuuming process of the freeze-drying chamber, the condensed water inside the system is removed, and then the material is crushed under completely dry conditions.
[0061] CIP cleaning is also the same Figure 4 As shown:
[0062] Cleaning liquid enters the system through the air outlet 28, backwashing the filter membrane within the vacuum suction machine 46. The clear liquid then flows into the pulverizer 30 and into the bottom liquid collection hopper 39. Initially, the clear liquid is discharged only through the suction port 29. At this point, the granulator is immersed, and its agitator 41 rotates, driving the liquid to dislodge material from the screen 42. After a period of time (7-15 minutes), the suction port 29 is closed and the drain port 40 is opened, allowing the soaking liquid within the pulverizer 30 to be drained from the drain port 40. After a period of time (7-15 minutes), all liquid within the pulverizer 30 is drained. The preferred cleaning process is to first rinse and flush the system with domestic water using the above-described procedure, followed by a 1-3% NaOH solution at 50-70°C, and finally with pure water, until the conductivity of the effluent at the drain port 40 is the same as that of pure water.
[0063] The above technical solution illustrates the technical idea of the present invention, but cannot be used to limit the protection scope of the present invention. Any changes and modifications made to the above technical solution based on the technical essence of the present invention without departing from the content of the technical solution of the present invention shall fall within the protection scope of the technical solution of the present invention.
Claims
1. A freeze dryer feeding and suction system, characterized by: Including freeze dryer second door, suction gun and suction crushing and encapsulation machine; The freeze dryer includes a freeze drying chamber and a freeze drying chamber door matched with the freeze drying chamber. Two doors are provided on the door frame at the entrance of the freeze drying chamber. The two doors include a flexible cover and a baffle. The baffle is provided at the entrance of the freeze drying chamber, and its edge is sealed to the door frame through the flexible cover. A sliding sealing assembly is provided in the middle of the baffle, and the sliding sealing assembly matches the suction pipe of the suction gun. A connecting valve is provided in the door frame, and the connecting valve is used to balance the pressure on both sides of the two doors between the freeze-drying chamber and the freeze-drying chamber door; The door frame is provided with a suction gun discharge port; the suction gun includes a suction head and a suction pipe; the suction pipe consists of two parts, one part is a hard pipe, and the other part is a hose; one end of the hard pipe passes through the sliding sealing assembly on the baffle and is connected to the suction head, and the other end is outside the baffle and is connected to one end of the hose, and the other end of the hose is connected to the suction gun discharge port; the suction gun discharge port is connected to the suction, crushing and encapsulation all-in-one machine.
2. A freeze dryer material intake and intake system according to claim 1, characterized in that: The freeze dryer is a freeze dryer with CIP cleaning and SIP steam sterilization functions. The door frame is provided with a CIP inlet connected to the freeze drying chamber, a feed pipe, and a return air port. The CIP inlet is connected to the spray head in the chamber, and the feed pipe is connected to the liquid distribution station for the freeze-dried product outside the chamber, which is used to add the liquid of the freeze-dried product to the surface of the plate layer in the chamber; the return air port is used to replenish gas to the chamber body.
3. A freeze dryer material intake and intake system according to claim 2, characterized in that: The door frame is provided with two door spray pipes connected with the CIP inlet, and the two door spray pipes are provided with spray heads.
4. A freeze dryer material intake and intake system according to claim 1, characterized in that: The length of the suction pipe hard tube is determined by whether the suction head can reach the innermost layer of the freeze-drying chamber when the baffle is near the door, and when the hard tube and the suction head are placed in the freeze-drying chamber, the freeze-drying chamber door can be closed.
5. A freeze dryer material intake and intake system according to claim 1, characterized in that: The feeding and suction system also includes a four-axis robot; the four-axis robot is connected to the suction gun and the baffle, and is used to realize the linear movement of the suction head and the baffle in the front and back, left and right, and up and down directions, and the linear movement between the baffle and the suction head.
6. A freeze dryer material intake and intake system according to claim 5, characterized in that: The four-axis robot includes a linear guide rail, a vertical support, a vertical slide rail, a transverse slide rail, a transverse support, a longitudinal slide rail, and a longitudinal support; a longitudinal slide rail is slidably provided on the longitudinal support, a vertical support is provided on the longitudinal slide rail, a vertical slide rail is slidably provided on the vertical support, a transverse slide rail is provided on the vertical slide rail, a transverse support is slidably installed on the transverse slide rail, one end of the transverse support is connected to the baffle, a linear guide rail is also slidably provided on the transverse support, and the linear guide rail is connected to the suction pipe hard tube.
7. A freeze dryer material intake and intake system according to claim 1, characterized in that: The material suction, crushing and encapsulation integrated machine includes a completely sealed vacuum suction machine, a completely sealed crusher, and a material discharge and packaging mechanism connected in sequence; the suction port of the vacuum suction machine is connected to the discharge port of the suction gun, which is used to suck the material in the freeze-drying bin and perform gas-solid separation. The separated solid phase material enters the crusher for crushing; the material discharge and packaging mechanism is used to package and seal the crushed material.
8. The freeze dryer material feeding and suction system according to claim 1, characterized in that: The material suction, crushing and encapsulation integrated machine also includes a gas circulation system with a filtering function, including a vortex fan and a filter connected to it; the vortex fan is connected to the vacuum suction machine, and the filter is connected to the return air port of the freeze-drying bin; the vortex fan provides suction power for the vacuum suction machine, and the filter finely filters the sucked-out gas and replenishes it to the freeze-drying bin to achieve a closed-loop circulation of the gas during the suction process.
Citation Information
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