Apparatus and method for preparing nano-hydroxyapatite powder with controllable morphology

Abstract

The application provides a device and a method for preparing nano-hydroxyapatite powder with controllable morphology, which comprises a deposition device, a heating device, an ultrasonic device and a fixing device; the deposition device comprises a heating box, the bottom of the heating box is provided with an output end of the ultrasonic device and the heating device, and the internal cavity structure is provided with a deposition container; the fixing device comprises a lifting structure, the lifting structure is detachably connected with an anode and a cathode, and the anode and the cathode are electrically connected with an electrochemical workstation respectively; the cathode is arranged in a half-wrapping mode at the bottom and the side of the anode; the application has the advantages of simple structure, convenient operation, low cost, short time, large preparation amount, precise control of the grain morphology of nHA, greatly reduced synthesis cost of HA grain, and avoidance of the defects of long time and reaction by-products in the hydrothermal synthesis method.

Description

Technical Field

[0001] This invention belongs to the field of materials synthesis and preparation technology, specifically relating to an apparatus and method for preparing nano-hydroxyapatite powder with controllable morphology. Background Technology

[0002] Hydroxyapatite (Ca 10 (PO4)6(OH)2, abbreviated as HA, is a major inorganic component of the human skeleton. HA possesses excellent biocompatibility and bioactivity. After implantation, the calcium and phosphorus in HA are absorbed by body tissues, generating new bone tissue on its surface. Furthermore, an adhesive is formed between the implant and the human bone tissue, facilitating fusion. HA has wide applications not only in biomedicine but also in environmental functional materials, semiconductor materials, and catalyst support materials. However, the current crystal morphology, properties, and bioactivity of HA have not yet reached ideal levels, limiting its application in biomedicine and other fields. Research in nanotechnology indicates that when the powder size is at the nanoscale, its various properties are improved.

[0003] Nano-hydroxyapatite (nHA) exhibits superior physicochemical properties compared to ordinary hydroxyapatite, such as higher solubility, greater surface energy, and better bioactivity. Conventional methods for preparing nHA include solid-phase grinding, hydrothermal synthesis, chemical precipitation, sol-gel method, microemulsion method, and electrochemical deposition. Among these, hydrothermal synthesis is the most commonly used method. The advantages of hydrothermal synthesis for preparing nHA include: the product is crystalline, with uniform particle dispersion and small particle size; and the microstructure of nHA can be controlled by adjusting the solution pH, temperature, and reaction time. However, this method requires sophisticated equipment, is prone to side reactions, is unsuitable for large-scale production, and also suffers from low efficiency and high cost. Summary of the Invention

[0004] To address the problems existing in the prior art, the present invention provides an apparatus and method for preparing nano-hydroxyapatite powder with controllable morphology, which can avoid the disadvantages of low efficiency and high cost of other nano-hydroxyapatite preparation methods. At the same time, the grain morphology can be controlled by adjusting process parameters such as current density, deposition time, and solution concentration to prepare nano-hydroxyapatite powder that meets the requirements.

[0005] This invention is achieved through the following technical solution:

[0006] An apparatus for preparing nano-hydroxyapatite powder with controllable morphology includes a deposition apparatus, a heating apparatus, an ultrasonic apparatus, and a fixing apparatus.

[0007] The deposition apparatus includes a heating chamber, the bottom of which is provided with an ultrasonic device output end and a heating device, and the internal cavity structure is provided with a deposition container.

[0008] The fixing device includes a lifting structure, which is detachably connected to an anode and a cathode. The anode and cathode are electrically connected to an electrochemical workstation, respectively. The cathode is semi-enclosed and disposed at the bottom and side of the anode.

[0009] Furthermore, the fixing device includes four rectangularly distributed support columns and an H-shaped bracket, with the support column bodies fixedly connected to the four ends of the H-shaped bracket; a lifting structure is provided in the middle of the H-shaped bracket.

[0010] Furthermore, the lifting structure includes a slider and a lead screw threaded through and sleeved inside the slider, the slider being fixedly mounted in the middle of the H-shaped bracket;

[0011] The bottom of the lead screw is provided with a suspension plate, the suspension plate is provided with a wire through hole, and the suspension plate is connected to the anode and the cathode through a hook.

[0012] Furthermore, the anode is a plate-shaped structure made of graphite, and the inner wall roughness of the cathode is Ra0.8-1.6, and the outer wall roughness is Ra1.6-3.2.

[0013] Furthermore, the cathode has a bowl-shaped structure.

[0014] Furthermore, the cathode has an inverted conical structure with a deposition space at the bottom.

[0015] Furthermore, the cathode has an inverted conical structure with a detachable deposition space at the bottom.

[0016] Furthermore, the cathode is characterized by having a through hole on its top side for connecting a hook.

[0017] Furthermore, the inner wall of the heating chamber is equipped with a temperature control unit, a temperature sensing unit, and a thermometer, and an electric heating tube is installed at the bottom; the thermometer is used to display the temperature, and the temperature control unit and the temperature sensing unit are used to maintain the temperature of the electrolyte at a constant level.

[0018] Furthermore, the ultrasonic device includes an ultrasonic transducer and an ultrasonic probe electrically connected to the ultrasonic transducer, the ultrasonic probe being disposed at the bottom of the heating chamber.

[0019] A method for preparing nano-hydroxyapatite powder with controllable morphology includes the following steps:

[0020] Electrolyte is added to the deposition container. The lifting structure is detachably connected to the anode and cathode. The anode and cathode are placed into the deposition container at a preset height through the lifting structure.

[0021] Add water to the heating chamber and heat it to the preset temperature. Start the ultrasonic device to the preset frequency and power. The electrochemical workstation supplies power to the anode and cathode.

[0022] After centrifuging and drying the precipitated nHA, nano-hydroxyapatite powder was obtained.

[0023] Compared with the prior art, the present invention has the following beneficial technical effects:

[0024] This invention provides an apparatus and method for preparing nano-hydroxyapatite powder with controllable morphology, including a deposition device, a heating device, an ultrasonic device, and a fixing device. The deposition device includes a heating chamber with an ultrasonic output end and a heating device at the bottom, and a deposition container in an internal cavity structure. The fixing device includes a lifting structure, which is detachably connected to an anode and a cathode, which are electrically connected to an electrochemical workstation. The cathode is semi-enclosed at the bottom and side of the anode. This invention has a simple structure and is easy to operate. Compared with existing technologies such as hydrothermal methods for preparing nHA powder, it is lower in cost and shorter in time, requiring only 3-4 hours for a single process, which is only one-tenth the time required by hydrothermal methods. The yield is larger in the same amount of time, about three times that of existing hydrothermal methods. At the same time, this invention can adjust the process to precisely control the crystal morphology of the prepared nHA, significantly reducing the cost of HA crystal synthesis compared to other methods, while avoiding the disadvantages of long time and reaction byproducts in hydrothermal synthesis. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the apparatus for preparing nano-hydroxyapatite powder with controllable morphology according to the present invention.

[0026] Figure 2 This is a cross-sectional view of an apparatus for preparing nano-hydroxyapatite powder with controllable morphology according to the present invention.

[0027] Figure 3 This is a schematic diagram of a cathode structure in a specific embodiment of the present invention;

[0028] Figure 4 This is a schematic diagram of another cathode structure in a specific embodiment of the present invention;

[0029] Figure 5 This is a schematic diagram of another cathode structure in a specific embodiment of the present invention;

[0030] Figure 6 This is a SEM image of nHA one hour after deposition in Example 1;

[0031] Figure 7 This is a SEM image of nHA three hours after deposition in Example 2;

[0032] Figure 8This is a SEM image of nHA one hour after ultrasonic-assisted deposition in Example 3 of the present invention;

[0033] Figure 9 This is a SEM image of nHA one hour after deposition of high-concentration electrolyte in Example 4 of the present invention.

[0034] In the diagram: 1. Stepper motor; 2. Lead screw; 20. Suspension plate; 21. Hook; 3. Slider; 4. Lifting structure; 40. Support column; 41. H-shaped bracket; 7. Ultrasonic probe; 8. Anode; 9. Cathode; 10. Temperature control unit and temperature sensing unit; 11. Thermometer; 12. Deposition container; 13. Electric heating tube; 14. Electrochemical workstation; 15. Heating box; 16. Ultrasonic instrument. Detailed Implementation

[0035] The present invention will be further described in detail below with reference to specific embodiments. These descriptions are for explanation purposes only and are not intended to limit the scope of the invention.

[0036] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present invention.

[0037] It should be noted that the terms "first," "second," etc., in the specification, claims, and accompanying drawings of this invention are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of the invention described herein can be implemented in orders other than those illustrated or described herein. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover a non-exclusive inclusion; for example, a process, method, system, product, or apparatus that comprises a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to such processes, methods, products, or apparatus.

[0038] This invention provides an apparatus for preparing nano-hydroxyapatite powder with controllable morphology, such as... Figure 1 and Figure 2As shown, it includes a deposition device, a heating device, an ultrasonic device, and a fixing device; the deposition device includes a heating box 15, the bottom of which is provided with an ultrasonic device output end and a heating device, and the internal cavity structure is provided with a deposition container 12; the fixing device includes a lifting structure 4, which is detachably connected to an anode 8 and a cathode 9, and the anode 8 and cathode 9 are electrically connected to an electrochemical workstation 14 respectively; the cathode 9 is semi-enclosed and disposed at the bottom and side of the anode 8.

[0039] Preferably, the fixing device includes four rectangularly distributed support columns 40 and an H-shaped bracket 41, with the support column 40 rods fixedly connected to each of the four ends of the H-shaped bracket 41; a lifting structure 4 is provided in the middle of the H-shaped bracket 41; further, the lifting structure 4 includes a slider 3 and a lead screw 2 threaded through and sleeved in the slider 3, the slider 3 being fixedly located in the middle of the H-shaped bracket 41; a suspension plate 20 is provided at the bottom of the lead screw 2, the suspension plate 20 having a wire through hole, and the suspension plate 20 being connected to the anode 8 and the cathode 9 via a hook 21; specifically, those skilled in the art can provide a stepper motor 1 at the end of the lead screw 2 to control the rotation of the lead screw 2, and control the lifting of the anode 8 and the cathode 9 by simultaneously cutting off the power.

[0040] Preferably, the anode 8 is a plate-shaped structure made of graphite, and the inner wall roughness of the cathode 9 is Ra0.8-1.6, and the outer wall roughness is Ra1.6-3.2. According to a large number of experiments provided in this application, when the inner wall roughness of the cathode 9 is Ra0.8-1.6, the precipitate produced by the reaction is highly efficient.

[0041] Preferred, such as Figure 3 As shown, the cathode 9 has a bowl-shaped structure, which is used to prepare a small amount of precipitate for easy and rapid collection. The specific dimensions are outer diameter D = 125-150 mm, inner diameter d = 120-140 mm, and wall thickness should be 5-10 mm.

[0042] Preferred, such as Figure 4 As shown, the cathode 9 has an inverted conical structure with a deposition space at the bottom. The deposition space is a barrel-shaped structure, integrally set with the inverted conical structure, which facilitates the collection of more precipitate. Its specific dimensions are D = 125-150 mm, d = 120-140 mm, H = 55-65 mm, b1 = 55-65 mm, b2 = 60-70 mm, L = 100-125 mm, and θ = 40-50°.

[0043] Preferred, such as Figure 5 As shown, the cathode 9 has an inverted conical structure with a detachable deposition space at the bottom. This deposition space is a barrel-shaped structure, detachably connected to the inverted conical structure via threads, and is used for continuous, large-scale preparation. By replacing the deposition space, a large amount of precipitate can be continuously collected. Its specific dimensions are:

[0044] D=125-150mm, d=120-140mm, H=55-65mm, h1=10mm, h2=12mm,

[0045] b1=75-85mm, b2=80-90mm, L1=75-85mm, L2=80-90mm, R=8-10mm, θ

[0046] =40-50°, r is for M12-M16 threaded holes.

[0047] Preferably, the top side of the cathode 9 is provided with a through hole for connecting the hook 21. Specifically, according to a large number of experiments provided in this application, the reaction effect is best when the distance between the inner wall of the cathode 9 and the outer wall of the anode 8 is between 20-30mm. At the same time, the hook 21 is made of stainless steel.

[0048] Preferably, the inner wall of the heating box 15 is provided with a temperature control unit, a temperature sensing unit 10 and a thermometer 11, and an electric heating tube 13 is provided at the bottom; the thermometer 10 is used to display the temperature, and the temperature control unit and the temperature sensing unit 11 are used to maintain the temperature of the electrolyte constant.

[0049] Preferably, the ultrasonic device includes an ultrasonic transducer 16 and an ultrasonic probe 7 electrically connected to the ultrasonic transducer 16, wherein the ultrasonic probe 7 is disposed at the bottom of the heating chamber 15.

[0050] This invention provides a method for preparing nano-hydroxyapatite powder with controllable morphology, comprising the following steps:

[0051] Electrolyte is added to the deposition container 12. The lifting structure 4 is detachably connected to the anode 8 and the cathode 9. The anode 8 and the cathode 9 are placed into the deposition container 12 at a preset height through the lifting structure 4.

[0052] Water is added to the heating box 15 and heated to the preset temperature. The ultrasonic device is started to the preset frequency and power. The electrochemical workstation 14 supplies power to the anode 8 and the cathode 9.

[0053] After centrifuging and drying the precipitated nHA, nano-hydroxyapatite powder was obtained.

[0054] Specifically, those skilled in the art can improve the reaction rate and deposition efficiency by adjusting the electrochemical deposition process parameters, using the temperature data collected by the temperature control unit and temperature sensing unit 10, the electrochemical workstation 14, and the ultrasonic instrument 16 to monitor and adjust the reaction process in real time.

[0055] Example 1:

[0056] Step 1: Weigh out a certain mass of ammonium dihydrogen phosphate (NH4H2PO4), calcium nitrate (Ca(NO3)2), and sodium nitrate (N2PO4). a NO3) was prepared into solutions with deionized water at concentrations of 3.80×10-4 mol / L, 6.35×10-4 mol / L and 0.10 mol / L. The electrolyte was prepared by mixing the above three solutions in a 1:1:1 ratio to ensure that the Ca / P molar ratio was 1.67.

[0057] Step 2, then take (NH4H2PO4), Ca(NO3)2 and N a Mix 100 ml of each NO3 solution to prepare the electrolyte. Use a magnetic stirrer to ensure uniform mixing. Use a pH meter to monitor the pH value in real time. Gradually add dilute HNO3 or NH3·H2O to adjust the initial pH value of the electrolyte to 6.00±0.02.

[0058] Step 3, nHA deposition: Pour the electrolyte prepared in steps (1) and (2) above into an electrolyte cup, heat and keep warm for 15 minutes, setting the temperature to 100℃; perform the first electrochemical deposition of the nHA coating in constant current mode, with a current density of 5.0 mA / cm². 2 The deposition time was 3600s; throughout the process, process parameters such as current density and deposition time were adjusted using an electrochemical workstation.

[0059] Step 4: After deposition, remove the cathode and place the collected nHA in a centrifuge tube. Centrifuge the collected nHA in a centrifuge at a speed of 4000 r / min for 2 min.

[0060] Step 5: Dry the collected nHA in a drying oven at 60°C for 12 hours to obtain nHA powder.

[0061] Figure 6 The image shows the SEM image of nHA under the above deposition conditions. The microstructure of nHA shows that the nHA grains are nanoneedle-shaped with a diameter of 60-80 nm.

[0062] Example 2:

[0063] Step 1: (NH4H2PO4), calcium nitrate (Ca(NO3)2), and sodium nitrate (N a NO3) was prepared into solutions with deionized water at concentrations of 3.80×10-4 mol / L, 6.35×10-4 mol / L and 0.10 mol / L. The electrolyte was prepared by mixing the above three solutions in a 1:1:1 ratio to ensure that the Ca / P molar ratio was 1.67.

[0064] Step 2, then take (NH4H2PO4), Ca(NO3)2 and Na Mix 100 ml of each NO3 solution to prepare the electrolyte. Use a magnetic stirrer to ensure uniform mixing. Use a pH meter to monitor the pH value in real time. Gradually add dilute HNO3 or NH3·H2O to adjust the initial pH value of the electrolyte to 6.00±0.02.

[0065] Step 3, nHA deposition: Pour the electrolyte prepared in steps (1) and (2) above into an electrolyte cup, heat and keep warm for 15 minutes, setting the temperature to 100℃; perform the first electrochemical deposition of the nHA coating in constant current mode, with a current density of 5.0 mA / cm². 2 The deposition time was 3600s; throughout the process, process parameters such as current density and deposition time were adjusted using an electrochemical workstation.

[0066] Step 4: Repeat steps 1, 2, and 3 once every hour, for a total of three times.

[0067] Step 5: After deposition, remove the cathode and place the collected nHA in a centrifuge tube. Centrifuge the collected nHA in a centrifuge at a speed of 4000 r / min for 2 min.

[0068] Step 6: Dry the collected nHA in a drying oven at 60°C for 12 hours to obtain nHA powder.

[0069] Figure 7 The above-mentioned SEM images show the nHA under the above deposition conditions. The microstructure of nHA shows that, compared with Example 1, the length of nHA grains gradually increases and the aspect ratio increases by 2-3 times as the deposition time increases.

[0070] Example 3:

[0071] Step 1: Weigh out a certain mass of ammonium dihydrogen phosphate (NH4H2PO4), calcium nitrate (Ca(NO3)2), and sodium nitrate (N2PO4). a NO3) was prepared into solutions with deionized water at concentrations of 3.80×10-4 mol / L, 6.35×10-4 mol / L and 0.10 mol / L. The electrolyte was prepared by mixing the above three solutions in a 1:1:1 ratio to ensure that the Ca / P molar ratio was 1.67.

[0072] Step 2, then take (NH4H2PO4), Ca(NO3)2 and N a Mix 100 ml of each NO3 solution to prepare the electrolyte. Use a magnetic stirrer to ensure uniform mixing. Use a pH meter to monitor the pH value in real time. Gradually add dilute HNO3 or NH3·H2O to adjust the initial pH value of the electrolyte to 6.00±0.02.

[0073] Step 3, nHA deposition: Pour the electrolyte prepared in steps (1) and (2) above into an electrolyte cup, heat and keep warm for 15 minutes, setting the temperature to 100℃; perform the first electrochemical deposition of the nHA coating in constant current mode, with a current density of 5.0 mA / cm². 2 The ultrasonic frequency was 40 kHz, the ultrasonic power was 100 W, and the deposition time was 3600 s. Throughout the process, process parameters such as current density and deposition time were adjusted using an electrochemical workstation.

[0074] Step 4: After deposition, remove the cathode and place the collected nHA in a centrifuge tube. Centrifuge the collected nHA in a centrifuge at a speed of 4000 r / min for 2 min.

[0075] Step 5: Dry the collected nHA in a drying oven at 60°C for 12 hours to obtain nHA powder.

[0076] Figure 5 The above-mentioned SEM images of nHA under the deposition conditions show that, compared with Example 1, under the action of ultrasound assistance, the nHA grains changed from nanoneedle-shaped to nanohexagonal rod-shaped structures, and some spherical structures also appeared, with the diameter increasing from 60-80 nm to 200-280 nm.

[0077] Example 4:

[0078] Step 1: Weigh out a certain mass of ammonium dihydrogen phosphate (NH4H2PO4), calcium nitrate (Ca(NO3)2), and sodium nitrate (N2PO4). a NO3) was prepared into solutions with deionized water at concentrations of 1×10-3 mol / L, 1.67×10-3 mol / L and 0.10 mol / L. The electrolyte was prepared by mixing the above three solutions in a 1:1:1 ratio to ensure that the Ca / P molar ratio was 1.67.

[0079] Step 2, then take (NH4H2PO4), Ca(NO3)2 and N a Mix 100 ml of each NO3 solution to prepare the electrolyte. Use a magnetic stirrer to ensure uniform mixing. Use a pH meter to monitor the pH value in real time. Gradually add dilute HNO3 or NH3·H2O to adjust the initial pH value of the electrolyte to 6.00±0.02.

[0080] Step 3, nHA deposition: Pour the electrolyte prepared in steps (1) and (2) above into an electrolyte cup, heat and keep warm for 15 minutes, setting the temperature to 100℃; perform the first electrochemical deposition of the nHA coating in constant current mode, with a current density of 5.0 mA / cm². 2The deposition time was 3600s; throughout the process, process parameters such as current density and deposition time were adjusted using an electrochemical workstation.

[0081] Step 4: After deposition, remove the cathode and place the collected nHA in a centrifuge tube. Centrifuge the collected nHA in a centrifuge at a speed of 4000 r / min for 2 min.

[0082] Step 5: Dry the collected nHA in a drying oven at 60°C for 12 hours to obtain nHA powder.

[0083] Figure 9 The above-mentioned SEM images of nHA under the above deposition conditions show that, compared with Example 1, as the electrolyte concentration increases, the nHA crystals are mostly in the form of nanorods and nanosheets, and some nanosheets even agglomerate into nanobulb-shaped crystals.

[0084] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An apparatus for preparing nano-hydroxyapatite powder with controllable morphology, characterized in that, It includes a deposition apparatus, a heating apparatus, an ultrasonic apparatus, and a fixing apparatus; The deposition apparatus includes a heating chamber (15), the bottom of which is provided with an ultrasonic device output end and a heating device, and the internal cavity structure is provided with a deposition container (12); the inner wall of the heating chamber (15) is provided with a temperature control unit, a temperature sensing unit (10) and a thermometer (11), and the bottom is provided with an electric heating tube (13); the thermometer (11) is used to display the temperature, and the temperature control unit and the temperature sensing unit (10) are used to maintain the temperature of the electrolyte constant; The ultrasonic device includes an ultrasonic instrument (16) and an ultrasonic probe (7) electrically connected to the ultrasonic instrument (16), wherein the ultrasonic probe (7) is disposed at the bottom of the heating box (15). The fixing device includes four rectangular support columns (40) and an H-shaped bracket (41). The four ends of the H-shaped bracket (41) are respectively fixedly connected to the support column (40) body. A lifting structure (4) is provided in the middle of the H-shaped bracket (41). The lifting structure (4) includes a slider (3) and a screw (2) threaded through and sleeved in the slider (3). The slider (3) is fixedly provided in the middle of the H-shaped bracket (41). A suspension plate (20) is provided at the bottom of the screw (2). The suspension plate (20) is provided with a wire through hole. The suspension plate (20) is detachably connected to the anode (8) and the cathode (9) through a hook (21). The cathode (9) is a bowl-shaped or inverted cone-shaped structure. The anode (8) and cathode (9) are electrically connected to the electrochemical workstation (14); the cathode (9) is semi-enclosed at the bottom and side of the anode (8).

2. The apparatus for preparing morphology-controllable nano-hydroxyapatite powder according to claim 1, characterized in that, The anode (8) is a plate-shaped structure made of graphite, and the inner wall roughness of the cathode (9) is Ra0.8-1.6, and the outer wall roughness is Ra1.6-3.

2.

3. The apparatus for preparing morphology-controllable nano-hydroxyapatite powder according to claim 1, characterized in that, The cathode (9) has an inverted conical structure with a deposition space at the bottom.

4. The apparatus for preparing morphology-controllable nano-hydroxyapatite powder according to claim 1, characterized in that, The cathode (9) has an inverted conical structure and a disassembly deposition space at the bottom.

5. The apparatus for preparing morphology-controllable nano-hydroxyapatite powder according to claim 1, 3, or 4, characterized in that, The cathode (9) has a through hole on its top side for connecting the hook (21).

6. A method for preparing nano-hydroxyapatite powder with controllable morphology, characterized in that, An apparatus for preparing morphology-controllable nano-hydroxyapatite powder according to any one of claims 1-5 includes the following steps: Electrolyte is added into the deposition container (12). The lifting structure (4) is detachably connected to the anode (8) and the cathode (9). The anode (8) and the cathode (9) are placed into the deposition container (12) at a preset height through the lifting structure (4). Add water to the heating box (15) and heat it to the preset temperature. Start the ultrasonic device to the preset frequency and power. The electrochemical workstation (14) supplies power to the anode (8) and cathode (9). After centrifuging and drying the precipitated nHA, nano-hydroxyapatite powder was obtained.

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