A blood vessel perfusion device for cattle

Abstract

This invention discloses a bovine vascular perfusion device, comprising: a puncture device, a catheter, an infusion device, and a fixator. The puncture device includes a guide tube, a puncture port at one end of the guide tube, and a handle fixed to the guide tube. The infusion device includes an infusion catheter, a movable stop clamp mounted on the infusion catheter, a silicone connector at one end of the infusion catheter that connects to a connector at the end of the catheter, and a tee at the other end of the infusion catheter. The fixator includes a fixation plate and a catheter channel fixed to the front of the fixation plate and wrapping the infusion catheter. The fixator is fixed to the animal's skin using medical adhesive on the back of the fixation plate, thereby tightly adhering the external portion of the infusion catheter to the animal's skin. This invention is easy to insert, easy to fix, has a good connection effect, and is not easy to fall off. It can solve the problems of lack of perfusion devices that match the body size, skin, and vascular characteristics of large animals such as cattle in current vascular perfusion experiments, as well as the difficulty in fixing external catheters.

Description

Technical Field

[0001] This invention relates to the technical field of animal husbandry and veterinary medicine and zoology, and in particular to a vascular perfusion device for cattle, suitable for vascular perfusion experiments in large animals such as cattle. Background Technology

[0002] Animal metabolism is a constantly changing dynamic process, and understanding and monitoring the metabolic state of animals remains a continuous research need in the fields of animal husbandry and veterinary medicine. Traditional research methods often only measure physiological indicators of animals at a single point in time, making it difficult to gain a deep understanding of the dynamic process of animal metabolism. Hemocatheterization technology has unparalleled advantages over traditional methods in studying the dynamic process of animal nutrition and physiological metabolism. Hemocatheterization technology refers to the placement of a blood catheter in a blood vessel at one or more locations within an animal, thereby enabling convenient and continuous blood collection and / or infusion of metabolic interventions to study the dynamic process of animal metabolism. Using laboratory animals as experimental materials and employing hemocatheterization technology to study the nutritional physiology and metabolic patterns of animals has broad application prospects. Key aspects of successful hemocatheterization surgery include appropriate anesthesia, correct catheter placement, suitable hemocatheterization (blood perfusion) device, reliable fixation of the catheter inside and outside the body, postoperative infection control, and prevention of blood clot blockage (generally using heparinized saline to clear the catheter). Among these, the blood perfusion device is the material basis of hemocatheterization surgery and one of the key aspects.

[0003] Currently, there are no blood catheterization devices available on the market suitable for large animals. Therefore, when conducting vascular perfusion experiments on large animals such as dairy cows, it is necessary to use relevant medical devices from human medical institutions. Among them, human central venous catheters (PICC) are usually used as substitutes for blood catheterization materials, and Silex is generally used as a substitute when fixing external catheters to the body surface.

[0004] To address the high costs associated with PICC (Peripherally Inserted Central Catheter) replacement, the inventors previously designed a bovine vascular perfusion device, comprising an inlet tube, catheter, connector, three-way connector, and fixation claws, using a multi-component combination. This partially solved the problems of high costs associated with borrowing human medical devices and the lack of suitable animal fixation devices. However, because the connector uses an internal hook structure, after surgery, when delivering lipid substances, material and blood can easily accumulate at the internal hook, causing difficulties in blood aspiration and catheter blockage later on. Secondly, the traditional three-way connector uses a knob switch to adjust the position of the small hole on the three-way channel to open and close the three-way tube. However, because the orifice diameter is too small, it may become blocked after repeated use. Furthermore, the knob switch requires two hands to operate; otherwise, single-handed operation can easily pull on the catheter. Additionally, the fixation claws require piercing the animal's skin to secure the catheter, which may cause some irritation (see...). Figure 5Furthermore, the fixation claw is too large, and the animal's movements can easily snag on the fixation claw and pull on the catheter, causing the perfusion catheter to become detached from the blood vessel.

[0005] Therefore, in response to the problems encountered in current bovine vascular perfusion experiments, a blood catheterization assembly suitable for cattle is needed. This assembly should have features such as easy catheter insertion, easy operation of the catheter material flow switch, and full-coverage surface fixation of the catheter. Summary of the Invention

[0006] Based on the shortcomings of existing technologies, the technical problem to be solved by the present invention is to provide a bovine vascular perfusion device with a simple structure, reasonable design, good safety, easy insertion, easy fixation, good connection effect, and not easy to fall off. It can solve the problems of lack of perfusion devices that match the characteristics of large animals such as cattle in current vascular perfusion experiments, and the inability of surface catheters to be completely covered and fixed.

[0007] To achieve the above objectives, the present invention employs the following technical measures:

[0008] A bovine vascular perfusion device includes: a puncture device, a catheter, an infusion device, and a fixator; the puncture device includes a guide tube through which the catheter can pass, a puncture port at one end of the guide tube, and a handle fixed to the guide tube; the infusion device includes an infusion catheter, a movable stop clamp disposed on the infusion catheter, a silicone connector at one end of the infusion catheter that connects to a connector at the tail end of the catheter, and a tee at the other end of the infusion catheter; the fixator includes a fixation plate, a catheter channel fixed to the front of the fixation plate and wrapping the infusion catheter, and the fixator is fixed to the animal skin by medical adhesive on the back of the fixation plate, thereby tightly adhering the external part of the infusion catheter to the animal skin.

[0009] Preferably, the three-way valve is provided with an inlet for injection and a heparin outlet.

[0010] As described above, the end of the catheter can be connected to the silicone connector of the infusion device. The end of the infusion device is a T-connector, which connects the infusion catheter, the infusion port, and the heparin port. After the infusion device and the catheter are connected, external substances are introduced into the catheter through the T-connector.

[0011] Furthermore, the front end of the silicone connector is made of highly elastic soft silicone material and is tightly connected to the connector of the catheter; the stop clamp can slide and adjust its position on the infusion catheter and the catheter.

[0012] Optionally, the catheter is provided with graduations.

[0013] Furthermore, the conduit channel is composed of two wings, one of which is provided with a circular protrusion, and the other wing is provided with a circular groove corresponding to the circular protrusion. The two wings are connected to form the conduit channel by the interlocking of the circular protrusion and the circular groove.

[0014] Optionally, the infusion catheter of the external portion passes through the catheter channel and is fixed to the fixing plate by the interlocking of the circular protrusion and the circular groove.

[0015] As shown above, the circular protrusions and circular grooves on the two wings of the fixator located on the body surface can be interlocked to form a catheter channel. The formed catheter channel completely covers the catheter exposed on the body surface. The medical adhesive on the back of the fixator can stick the fixator to the animal's body surface, thereby making the catheter adhere tightly to the animal's skin.

[0016] In previous bovine vascular perfusion experiments, it was difficult to find suitable in vivo blood catheter materials and fittings of appropriate sizes. Human central venous catheters (PICCs) were often used as substitutes, requiring the use of skin retractors and other human medical materials during insertion. These components were complex, expensive, and difficult to obtain. The puncture device of this invention is simple in structure and easy to operate. After locating the target blood vessel during surgery, the puncture site is aligned with the vessel and inserted at an angle. The guide tube serves as the catheter channel, providing excellent assistance during insertion and allowing for rapid and smooth placement of the catheter into the target blood vessel.

[0017] In previous experiments, Stratocupants were used to fix ducts exposed on the animal's body surface. Stratocupants are expensive, and due to animal behavior, they are easily scratched during daily activities, leading to displacement and loosening. Furthermore, while Stratocupants can provide point anchoring for duct fixation, the ducts between the Stratocupants are still exposed on the animal's body surface, making it impossible to prevent animals from licking or biting them. Therefore, ducts are prone to loosening and breakage. The fixator designed in this invention wraps around the ducts on the body surface and adheres tightly to the animal's body, providing a large coverage area with no obvious protrusions, thus reducing the risk of duct loosening caused by animal activity.

[0018] The fixator of this invention has a larger skin contact area and a smaller protrusion on the animal's body surface, making it fit the skin better overall. The full coverage of the catheter prevents it from shaking during daily activities and from being hooked or pulled, which could cause the catheter to shift or loosen.

[0019] Compared with the prior art, the key components of the bovine blood cannulation device of the present invention are the infusion device and the fixator, and its beneficial effects and advantages are as follows:

[0020] 1. The infusion device of this invention has a built-in tee and a stop clamp, which solves the problem that the size of the catheter and the tee are not completely matched when using an external tee, making it difficult to completely seal the interface and posing a risk of loosening. The silicone connector at the front end of the infusion device has high elasticity and high friction, which can fit tightly with the catheter. Unlike the rotary switch of the original tee connector, which requires one hand to hold the tee connector and the other hand to turn the rotary switch, the stop clamp with the snap-fit ​​structure is simpler to operate and can be operated with one hand.

[0021] 2. The device of the present invention has a fixator that can wrap around a large area or even completely the exposed part of the catheter and fix it tightly against the skin, which greatly reduces the volume of the original fixation components of the Sleek buckle and fixation clamp. The full coverage fixation avoids the shaking of the external catheter during the animal's daily activities. In addition, after the catheter channel is formed, the fixator of the present invention has a small protrusion on the body surface and is not easy to be scratched or snagged, reducing the displacement of the catheter due to the animal's activities. Attached Figure Description

[0022] To more clearly illustrate the technical solution of the present invention, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the puncture device of the present invention;

[0024] Figure 2 This is a schematic diagram of the structure of the catheter of the present invention;

[0025] Figure 3 This is a schematic diagram of the infusion device of the present invention;

[0026] Figure 4 This is a schematic diagram of the structure of the fixator of the present invention;

[0027] Figure 5 The diagram shows the structure of an existing bovine blood cannula assembly, where (a) is a schematic diagram of the connector, (b) is a schematic diagram of the tee connector, and (c) is a schematic diagram of the body surface fixation clip.

[0028] The components are: 1-puncture device, 2-catheter, 3-infusion device, 4-fixator, 5-puncture port, 6-guide tube, 7-handle, 8-gradation, 9-connector, 10-silicone connector, 11-stop clamp, 12-infusion catheter, 13-tee, 14-infusion port, 15-heparin port, 16-fixation plate, 17-wing surface, 18-circular protrusion, 19-circular groove, 20-catheter channel. Detailed Implementation

[0029] See below. Figures 1-4 The bovine vascular perfusion device described in this invention will be described in detail.

[0030] Example 1:

[0031] like Figure 1-4 As shown, the bovine vascular perfusion device provided by this invention includes a puncture device 1 capable of piercing the blood vessel wall, a catheter 2, an infusion device 3, and a fixator 4. The puncture device 1 includes a guide tube 6 that accommodates the catheter 2. One end of the guide tube 6 is a puncture port 5 capable of piercing the blood vessel wall. The guide tube 6 has a smooth, hollow structure, and a handle 7 is fixed to it. The catheter 2 has graduations 8. After the puncture port 5 of the puncture device 1 pierces the arterial wall, the catheter 2 can be inserted into the target blood vessel through the guide tube 6 on the puncture device 1.

[0032] Furthermore, the infusion device 3 provided by this invention has a silicone connector 10 at its front end, which can be connected to the connector 9 at the tail end of the catheter 2. After connection, due to the elasticity and high friction of the silicone connector, the catheter and the infusion catheter can be tightly connected and are not easy to loosen. The stop clamp 11 provided on the infusion device 3 serves as a switch between the catheter 2 and the infusion device 3. In the open and closed state, the stop clamp can move between the catheter and the infusion catheter. After the stop clamp 11 is engaged, the flow of substances between the catheter 2 and the infusion device 3 is closed.

[0033] The fixator 4 of the present invention includes a fixation plate 16, on which two wings 17 are provided, each with a circular protrusion 18 and a circular groove 19. The two wings can be fastened together by the protrusion and groove, and after fastening, the two wings can accommodate the catheter channel 20 of the infusion catheter body. After fastening, the external portion of the catheter is completely covered by the two wings of the fixation plate, and the fixator 4 is fixed to the skin by the medical adhesive on the back side of the fixation plate 16, thereby adhering the external portion of the infusion catheter 12 to the animal's skin.

[0034] The infusion catheter 12 of this invention has a built-in tee 13 at its tail end, which solves the problem of incomplete matching between the size of the tee connector and the catheter in the original device. The stop clamp replaces the original rotary switch of the tee connector, making operation simpler and allowing for one-handed operation. The fixator 4 uses two wings to wrap around the external portion of the catheter. After wrapping, the exposed portion of the catheter is attached to the skin surface along with the fixation plate 16. Unlike the original gripper fixator and sleek fastener, the fixator 4 of this invention can completely wrap around the external portion of the catheter. After being attached to the skin, it reduces the volume of the original sleek fastener and gripper fixing components. There are no gaps between the catheter and the skin, which can prevent the animal from snagging or pulling on the catheter, causing it to loosen.

[0035] Experimental example:

[0036] To perform external pudendal artery catheterization on dairy cows, after restraining the cow, clip the hair at a soft triangular area about 5cm below the posterior border of the lateral angle of the iliac bone (3cm-5cm). After cleaning, disinfect with 5% iodine solution and remove the iodine with 75% alcohol. Inject the local anesthetic procaine. Two minutes later, insert one hand into the cow's anus and locate the artery about the thickness of a little finger inside the intestine. Gently pinch the artery with your fingers. Locate the corresponding location on the lateral side with your other hand and insert the puncture device 1 slowly, about 15cm. At this point, you can feel a slight squeezing sensation. Once the puncture site 5 is aligned with the location, puncture the vessel wall, and bright red blood will spurt out. Quickly insert the catheter 2 into the guide tube 6 of the puncture device 1. While inserting the catheter 2, slowly withdraw the puncture device 1. When the catheter 2 is about 10-15cm into the blood vessel, quickly withdraw the puncture device 1. When withdrawing the puncture device 1, be careful to hold and fix the catheter at the puncture site to prevent the catheter 2 from being withdrawn along with the puncture device 1. After the puncture device 1 is withdrawn from the body, immediately connect the connector 9 at the end of the catheter to the silicone connector 10 of the infusion device 3. The stop clamp 11 of the infusion device 3 needs to be opened in advance to purge air into the infusion catheter 12 before injecting heparin sodium. After connecting the catheter 2 and the infusion device 3, infuse heparin sodium into the catheter 2 through the infusion port to keep the catheter and blood vessel patent. When opening and closing the stop clamp 11, the stop clamp 11 can be moved towards the catheter 2 to bring it closer to the puncture site. When infusing heparin sodium, a positive pressure sealing method can be used, that is, when there are 5 ml of heparin sodium left in the syringe, inject heparin sodium into the catheter by pushing and stopping. When there are about 2 ml of heparin sodium left, push the syringe while withdrawing the syringe from the infusion port, and immediately close the stop clamp 11 after withdrawal. When fixing the catheter on the body surface, place the infusion catheter 12 on the body surface tightly against the middle position of the two wings 17 of the fixator 4, then fasten the circular protrusion 18 and circular groove 19 on the wings 17, and randomly attach the fixation plate 16 to the skin near the puncture site. The entire catheter insertion process is then completed.

[0037] This experiment included a 3-day postoperative recovery period. During this time, constant monitoring was required to prevent catheter dislodgement. For the first 24 hours post-surgery, 100 IU of heparin sodium was injected every 2 hours, followed by injections every 6 hours as needed. During the formal perfusion period, the catheter was pre-flushed and cleaned with saline before and after perfusion. Heparin sodium was injected every 6 hours throughout the experiment. Subsequently, constant attention was paid to the disinfection of the puncture site and the external catheter. The puncture site was disinfected three times daily, morning and evening, with iodine and alcohol applied three times each. The external portion of the catheter near the puncture site also needed disinfection during disinfection. The heparin cap at the heparin inlet was replaced weekly. In this case, heparin sodium was injected every 2 hours for the first 24 hours post-surgery. The concentration and frequency of heparin sodium injections were adjusted according to the bovine's vascular condition.

[0038] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any transformations or substitutions that can be understood by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of the present invention.

Claims

1. A blood vessel perfusion device for cattle, characterized by comprising: include: Puncture device (1), catheter (2), infusion device (3) and fixator (4); The puncture device (1) includes a guide tube (6) through which the catheter (2) can pass, a puncture port (5) located at one end of the guide tube (6), and a handle (7) fixed on the guide tube (6). The infusion device includes an infusion conduit (12) and a stop clamp (11) movably disposed on the infusion conduit (12). One end of the infusion conduit (12) is provided with a silicone connector (10) connected to the connector (9) at the tail end of the conduit (2), and the other end of the infusion conduit (12) is provided with a tee (13). The fixator (4) includes a fixation plate (16) and a catheter channel (20) fixed to the front of the fixation plate (16) and wrapping the infusion catheter (12). The fixator (4) is fixed to the animal skin by medical adhesive on the back of the fixation plate (16), thereby tightly adhering the external part of the infusion catheter (12) to the animal skin.

2. The bovine vascular perfusion device of claim 1, wherein, The three-way valve (13) is provided with an inlet (14) and a heparin inlet (15).

3. The bovine vascular perfusion device according to claim 1, characterized in that, The front end of the silicone connector (10) is made of highly elastic soft silicone material and is tightly connected to the connector (9) of the catheter (2); the stop clamp (11) can slide and adjust its position on the infusion catheter (12) and the catheter (2).

4. The bovine vascular perfusion device according to claim 1, characterized in that, The catheter (2) is provided with a scale (8).

5. The bovine vascular perfusion device according to claim 1, characterized in that, The conduit channel (20) is composed of two wings, one of which is provided with a circular protrusion (18), and the other wing is provided with a circular groove (19) corresponding to the circular protrusion (18). The two wings are connected by the circular protrusion (18) and the circular groove (19) to form the conduit channel (20).

6. The bovine vascular perfusion device according to claim 5, characterized in that, The infusion catheter (12) of the external part passes through the catheter channel (20) and is fixed to the fixing plate (16) by the interlocking of the circular protrusion (18) and the circular groove (19).

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