Reagent preparation device and sample analysis system

Abstract

The application belongs to the field of sample analysis system, and discloses a reagent preparation device and a sample analysis system, wherein the reagent preparation device comprises a first quantification system and a first mixing container; the first quantification system comprises a first quantification pool, a first liquid conveying pipeline, a second liquid conveying pipeline and a first liquid discharging pipeline; the first quantification pool is used for measuring the first liquid and the second liquid alternately; and the first mixing container is connected with the first quantification system, so as to mix the first liquid and the second liquid measured by the first quantification system to prepare the first reagent. In the application, the first quantification pool is used for measuring the first liquid and the second liquid alternately, and the structure is relatively simple, and the design and manufacturing costs are relatively low; and the number of times of measuring the first liquid and the second liquid in the process of preparing the first reagent once can be reduced, so that the preparation speed of the first reagent can be improved under the premise of low cost and small size.

Description

Technical Field

[0001] This invention relates to the field of sample analysis systems, and more particularly to a reagent preparation apparatus and a sample analysis system having such a reagent preparation apparatus. Background Technology

[0002] A common method for preparing reagents is to dilute the reagent stock solution with water to reduce it back to the reagent. This method involves separately metering the reagent stock solution and water using a quantitative device, then transferring them to a mixing container for further mixing. Traditionally, due to precision requirements, the common method for metering the reagent stock solution and water involves using a small-range quantitative device (such as a metering pump or syringe) for repeated metering. Each metering operation requires multiple steps, including pressure switching, valve control, liquid inlet and outlet, and these steps must be repeated dozens of times for each reagent preparation process. This method suffers from slow metering speed. To increase the metering speed, multiple metering pumps or syringes need to be connected in parallel. However, since metering pumps and syringes are highly integrated devices, they are expensive. Therefore, using multiple metering pumps or syringes in parallel significantly increases the cost and size of the reagent preparation device. Summary of the Invention

[0003] The first objective of this invention is to provide a reagent preparation apparatus that addresses the technical problems of conventional techniques that use metering pumps or syringes to prepare liquids for quantitative reagent preparation, which either result in slow reagent preparation speed or high reagent preparation cost and volume.

[0004] To achieve the above objectives, the present invention provides a reagent preparation apparatus, comprising:

[0005] A first metering system, the first metering system being used to measure a first liquid and a second liquid;

[0006] A first mixing container, connected to the first metering system, is used to mix the first liquid and the second liquid measured by the first metering system to prepare a first reagent;

[0007] The controller is used to control the first metering system to measure the first liquid and to control the first metering system to deliver the measured first liquid to the first mixing container, and to control the first metering system to measure the second liquid and to control the first metering system to deliver the measured second liquid to the first mixing container;

[0008] The first quantitative system includes:

[0009] A first metering chamber is used to measure the first liquid and the second liquid;

[0010] The first infusion line is connected to the first metering tank for delivering the first liquid to be measured into the first metering tank.

[0011] The second infusion line is connected to the first metering pool for delivering the second liquid to be measured into the first metering pool.

[0012] A first drain line is connected between the first metering tank and the first mixing container to drain the first liquid measured by the first metering tank into the first mixing container, and to drain the second liquid measured by the first metering tank into the first mixing container.

[0013] A second objective of the present invention is to provide a sample analysis system comprising a reagent preparation device and at least one sample processing device, wherein the reagent preparation device is used to deliver a first reagent prepared by mixing in the first mixing container to the sample processing device;

[0014] The reagent preparation apparatus includes:

[0015] A first metering system, the first metering system being used to measure a first liquid and a second liquid;

[0016] A first mixing container, connected to the first metering system, is used to mix the first liquid and the second liquid measured by the first metering system to prepare a first reagent;

[0017] The controller is used to control the first metering system to measure the first liquid and deliver the measured first liquid to the first mixing container, and to control the first metering system to measure the second liquid and deliver the measured second liquid to the first mixing container;

[0018] The first quantitative system includes:

[0019] A first metering chamber is used to measure the first liquid and the second liquid;

[0020] The first infusion line is connected to the first metering tank for delivering the first liquid to be measured into the first metering tank.

[0021] The second infusion line is connected to the first metering pool for delivering the second liquid to be measured into the first metering pool.

[0022] A first drain line is connected between the first metering tank and the first mixing container to drain the first liquid measured by the first metering tank into the first mixing container, and to drain the second liquid measured by the first metering tank into the first mixing container.

[0023] The reagent preparation apparatus and sample analysis system provided by this invention measure a first liquid and a second liquid separately using a first quantitative cell, and then mix the first liquid and the second liquid measured by the first quantitative cell in a first mixing container to prepare a first reagent, thereby realizing the preparation of the first reagent. Since the quantitative cell has no complex structural design, its structure is relatively simple, and the design and manufacturing costs are relatively low. Furthermore, in practical applications, the size of the quantitative cell can be flexibly designed according to the quantitative requirements of the first and second liquids to minimize the number of times the first and second liquids need to be quantified in a single preparation of the first reagent, thus achieving an increased speed of first reagent preparation under the premise of low cost and small volume. Attached Figure Description

[0024] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0025] Figure 1 This is a schematic diagram of the pipeline connection of the sample analysis system provided in Embodiment 1 of the present invention;

[0026] Figure 2 This is a schematic diagram of the pipeline connection of the reagent preparation device provided in Embodiment 1 of the present invention;

[0027] Figure 3 This is a schematic diagram of the pipeline connection between the first quantitative system and the first liquid supply device and the second liquid supply device provided in Embodiment 1 of the present invention;

[0028] Figure 4 This is a schematic diagram of the pipeline connection between the first quantitative system and the first liquid supply device and the second liquid supply device provided in Embodiment 2 of the present invention;

[0029] Figure 5 This is a schematic diagram of the pipeline connection between the first quantitative system and the first liquid supply device and the second liquid supply device provided in Embodiment 3 of the present invention;

[0030] Figure 6 This is a schematic diagram of the pipeline connection between the first quantitative system and the first liquid supply device and the second liquid supply device provided in Embodiment 4 of the present invention;

[0031] Figure 7 This is a schematic diagram of the pipeline connection between the first quantitative system and the first liquid supply device and the second liquid supply device provided in Embodiment 5 of the present invention;

[0032] Figure 8 This is a schematic diagram of the pipeline connection between the first quantitative system and the first liquid supply device and the second liquid supply device provided in Embodiment Six of the present invention;

[0033] Figure 9 This is a schematic diagram of the pipeline connection between the first quantitative system and the first liquid supply device and the second liquid supply device provided in Embodiment 7 of the present invention;

[0034] Figure 10 This is a schematic diagram of the pipeline connection of the sample analysis system provided in Embodiment 8 of the present invention;

[0035] Figure 11 This is a schematic diagram of the pipeline connection of the sample analysis system provided in Embodiment 9 of the present invention;

[0036] Figure 12 This is a schematic diagram of the pipeline connection of the sample analysis system provided in Embodiment 10 of the present invention.

[0037] Explanation of icon numbers:

[0038] 10. Reagent preparation apparatus; 100. First quantitative system; 110. First quantitative cell; 111. Cell body; 112. Cell nozzle; a. Overflow port; 113. Cell neck; 120. First infusion line; 121. First input branch; 130. First drain line; 140. First liquid flow control assembly; 141. First power component; 1411. First drive component; 1412. Second drive component; 142. First valve group Components; 1421, First reversing air valve; 1422, First switching liquid valve; 1423, First drain valve; 1424, Third switching liquid valve; 1425, Fourth switching liquid valve; 1426, Throttling device; 1427, First flow regulating valve; 1428, Second reversing air valve; 150, First liquid level detection component; 151, First electrode; 160, Second liquid level detection component; 161, Second electrode; 170, Overflow pipe; 171. Second drain valve; 180, second infusion line; 190, second liquid flow control assembly; 191, second valve assembly; 1911, second on / off valve; 200, second metering system; 300, first mixing container; 400, first venting detection component; 500, first storage container; 600, fourth buffer container; 700, third drain line; 800, third venting detection component; 900, supply line; 1001, third liquid level detection component; 1002, fourth liquid level detection component; 1003, suction control assembly; 1004, third storage container; 1005, second mixing container; 1006, suction line; 1007, second storage container; 20, first supply device; 30, second supply device; 40, first sample processing device; 50, first buffer container; 60, second sample processing device; 70, third sample processing device; 80, second buffer container. Detailed Implementation

[0039] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. In addition, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by the present invention.

[0040] Example 1:

[0041] like Figures 1 to 3As shown, the reagent preparation apparatus 10 provided in Embodiment 1 of the present invention includes a controller, at least one metering system, and at least one mixing container. Each metering system is used to measure two or more liquids and deliver them to the mixing container for mixing to prepare a reagent. The controller is used to control the metering system to measure the liquids and deliver the measured liquids to the mixing container.

[0042] In this embodiment, the reagent preparation apparatus 10 includes a first quantitative system 100, a first mixing container 300, and a controller. The first quantitative system 100 is used to measure a first liquid and a second liquid, i.e., the first quantitative system 100 is time-multiplexed for measuring the first liquid and the second liquid. The first mixing container 300 is connected to the first quantitative system 100 to mix the first liquid and the second liquid measured by the first quantitative system 100 to prepare a first reagent. The controller is used to control the first quantitative system 100 to measure the first liquid and to control the first quantitative system 100 to deliver the measured first liquid to the first mixing container 300, and to control the first quantitative system 100 to measure the second liquid and to control the first quantitative system 100 to deliver the measured second liquid to the first mixing container 300. The reagent preparation apparatus 10 provided in this embodiment, in which the first quantitative system 100 is time-multiplexed for measuring two different liquids, is suitable for solutions where two liquids are mixed to prepare a reagent. Of course, in specific applications, the number of times the first quantitative system can be reused for quantitative liquids in 100 minutes is not limited to this. For example, in applications where the reagent is prepared by mixing three liquids, the number of times the first quantitative system can be reused for quantitative liquids in 100 minutes can be set to three, while the first mixing container 300 can still be one; in applications where the reagent is prepared by mixing four liquids, the number of times the quantitative system can be reused for quantitative liquids in 100 minutes can be set to four, while the mixing container can still be one; in applications for preparing two or more reagents, the first mixing container 300 can be designed to be two or more, and the number of quantitative systems can be set to two or more.

[0043] In one embodiment, the first metering system 100 includes a first metering tank 110, a first infusion line 120, a second infusion line 180, and a first drain line 130. The first metering tank 110 is used to measure a first liquid and a second liquid; that is, the first metering tank 110 is time-divided for measuring both the first and second liquids. The first infusion line 120 is connected to the first metering tank 110 to deliver the first liquid to be measured into the first metering tank 110. The second infusion line 180 is connected to the first metering tank 110 to deliver the second liquid to be measured into the first metering tank 110. The first drain line 130 is connected between the first metering tank 110 and a first mixing container 300 to drain the first liquid measured by the first metering tank 110 into the first mixing container 300, and to drain the second liquid measured by the first metering tank 110 into the first mixing container 300. When the first quantitative system 100 measures the first liquid, it first delivers the first liquid to the first quantitative reservoir 110 via the first infusion line 120, and then discharges the measured first liquid from the first quantitative reservoir 110 to the first mixing container 300 via the first drainage line 130. When the first quantitative system 100 measures the second liquid, it first delivers the second liquid to the first quantitative reservoir 110 via the second infusion line 180, and then discharges the measured second liquid from the first quantitative reservoir 110 to the first mixing container 300 via the second drainage line. The first quantitative reservoir 110 is a container with a certain storage space inside and no power delivery function. Its structure is simple, and its design and manufacturing costs are relatively low. In specific applications, the size of the first quantitative reservoir 110 can be flexibly designed according to the quantitative requirements of the first and second liquids to minimize the number of times the first and second liquids need to be measured in a single preparation of the first reagent, thereby improving the preparation speed of the first reagent under the premise of low cost and small volume.

[0044] In one embodiment, the first metering tank 110 includes a tank body 111 and a nozzle 112. The nozzle 112 is located above the tank body 111 and communicates with the tank body 111. The inner diameter of the tank body 111 is larger than the inner diameter of the nozzle 112. In this embodiment, the first metering tank 110 adopts a bottom-larger-top-smaller configuration, which helps to improve the accuracy of metering liquid in the first metering tank 110.

[0045] In one embodiment, the spout 112 is spaced above the body 111, and the first metering tank 110 also includes a neck 113, which transitionally connects the body 111 and the spout 112. The neck 113 allows the inner diameter of the spout 112 to be designed to be much smaller than the inner diameter of the body 111, thereby further improving the accuracy of the metered liquid dispensed by the first metering tank 110 and helping to avoid stress concentration.

[0046] In one implementation, the pool neck 113 is tapered, extending from the pool body 111 to the pool spout 112 with a gradually decreasing inner diameter. This optimized shape of the pool neck 113 helps to better avoid stress concentration. Of course, in specific applications, the arrangement of the pool neck 113 is not limited to this. For example, as an alternative implementation, the pool neck 113 can also extend from the pool body 111 to the pool spout 112 in a stepped manner.

[0047] In one implementation, the outer diameter of the pool body 111 is also larger than the outer diameter of the pool nozzle 112, and the outer diameter of the pool neck 113 extends from the pool body 111 to the pool nozzle 112 in a gradually decreasing trend. This arrangement helps to make the wall thickness of the first metering pool 110 more uniform, thereby reducing the manufacturing difficulty of the first metering pool 110.

[0048] In one embodiment, the first infusion line 120 is connected to the side of the pool body 111 or the side of the pool neck 113, the second infusion line 180 is connected to the side of the pool body 111 or the side of the pool neck 113, and the first drain line 130 is connected to the bottom of the pool body 111. The positive pressure device for driving liquid out of the first metering pool 110 and the negative pressure device for drawing liquid into the first metering pool 110 are both connected to the spout 112 via an air passage. Here, by optimizing the connection positions of the first metering pool 110 and each line, it is beneficial to better draw the first and second liquids into the first metering pool 110 and to better and more completely drain the first and second liquids from the first metering pool 110.

[0049] In one embodiment, the first metering pool 110 is used to measure at least one of the first liquid and the second liquid in a single measurement required for the preparation of the first reagent. This allows the metering of at least one liquid to be completed in one operation, thereby reducing the number of times a liquid needs to be metered and thus improving the efficiency of the preparation of the first reagent.

[0050] In one embodiment, the first metering reservoir 110 is used to measure a specific amount of the second liquid required for preparing the first reagent in one step, and to measure the specific amount of the first liquid required for preparing the first reagent in at least two separate steps. The amount of the second liquid required for preparing the first reagent in one step is less than the amount of the first liquid required for preparing the first reagent in one step. The specific amount of the first liquid required for preparing the first reagent in one step refers to the amount of the first liquid required in preparing the reagent in one step, and the specific amount of the second liquid required for preparing the first reagent in one step refers to the amount of the second liquid required in preparing the reagent in one step. For example, if preparing the first reagent requires x ml of the first liquid and y ml of the second liquid, then the first metering reservoir 110 is used to measure y ml of the second liquid in one step, and the first metering reservoir 110 is used to measure x ml of the first liquid in at least two separate steps. The working principle of the first metering tank 110 for measuring the required amount of the second liquid in a single preparation of the first reagent is as follows: when the volume of the second liquid input into the metering tank by the first infusion line 120 is equal to the required volume of the second liquid in a single preparation of the first reagent, the first drainage line 130 discharges the second liquid in the first metering tank 110 into the first mixing container 300. This allows the metering of the second liquid to be completed in one operation, eliminating the need for repeated operations and greatly improving the efficiency of reagent preparation. In this embodiment, the first metering tank 110 is a small-capacity metering tank. Of course, in specific applications, as an alternative embodiment, the first metering tank 110 can also be a large-capacity metering tank, that is: the first metering tank 110 is used to measure the required amount of the first liquid in a single preparation of the first reagent, and also to measure the required amount of the second liquid in a single preparation of the first reagent.

[0051] In one implementation, the controller is configured to: first, control the first metering system 100 to measure the required amount of the second liquid in a single preparation of the first reagent and deliver it to the first mixing container 300; then, control the first metering system 100 to measure the required amount of the first liquid in a single preparation of the first reagent in at least two separate measurements and deliver it to the first mixing container 300. In this embodiment, the second liquid is first metered using the first metering tank 110, and then the first liquid is metered. Of course, in specific applications, the quantitative method of the first liquid and the second liquid is not limited to this. For example, as an alternative implementation, the controller is configured to: first control the first quantitative system 100 to measure the first liquid and deliver it to the first mixing container 300a times; then control the first quantitative system 100 to measure the required amount of the second liquid in one preparation of the first reagent and deliver it to the first mixing container 300 at once; then control the first quantitative system 100 to measure the first liquid and deliver it to the first mixing container 300b times, where a and b are both integers greater than 1, and the sum of the volume of the first liquid measured a times and the volume of the first liquid measured b times is equal to the volume of the first liquid required in the preparation of the first reagent; or, as another alternative implementation, the controller is configured to: first control the first quantitative system 100 to measure the required amount of the first liquid in one preparation of the first reagent at least twice and deliver it to the first mixing container 300; then control the first quantitative system 100 to measure the required amount of the second liquid in one preparation of the first reagent and deliver it to the first mixing container 300 at once.

[0052] In one embodiment, the reagent preparation device 10 is a device for diluting and reducing the first reagent stock solution to the first reagent using a diluent; that is, the reagent preparation device 10 is a diluent. Specifically, the second liquid is the first reagent stock solution, which is a first concentrated reagent, a high-concentration first reagent; the first liquid is a diluent used to dilute the first reagent stock solution. In a preferred embodiment of this example, the first liquid is pure water obtained by reverse osmosis membrane filtration. Of course, in specific applications, the first liquid is not limited to pure water obtained by reverse osmosis membrane filtration; for example, it can also be distilled water or other liquids that can be used as diluents. The reagent preparation device 10 is also not limited to a diluent; for example, it can also be other devices that use at least two liquids mixed to prepare the reagent.

[0053] In one embodiment, the second liquid is an N-fold concentrated reagent. The amount of the first liquid required to prepare the first reagent once is (N-1) times the amount of the second liquid required to prepare the first reagent once. The first metering pool 110 is used to measure the required amount of the second liquid in one preparation of the first reagent once, and to measure the required amount of the first liquid in one preparation of the first reagent in (N-1) separate times, where N is an integer greater than 2.

[0054] In one embodiment, the reagent preparation apparatus 10 further includes a second liquid level detection component 160, which is used to detect whether the first liquid in the first metering pool 110 has reached the second liquid level. The controller is also configured to: during the process of the first infusion line 120 or the second infusion line 180 delivering liquid to the first metering pool 110, when it is determined, based on the feedback information from the second liquid level detection component 160, that the liquid level in the first metering pool 110 has reached the second liquid level, determine that the liquid in the first metering pool 110 has reached the amount required for a single metering, and control the first infusion line 120 or the second infusion line 180 to stop delivering liquid to the first metering pool 110, and control the first drain line 130 to deliver the liquid in the first metering pool 110 to the first mixing container 300. In this implementation scheme, by setting a second liquid level detection component 160 in the first quantitative pool 110 to monitor whether the liquid is quantitatively measured, it is beneficial to improve the quantitative accuracy of the first liquid and the second liquid. After detecting that the liquid to be quantified in the first quantitative pool 110 has arrived, the quantitative process is stopped in advance and the quantitative drainage process of the liquid in the first quantitative pool 110 is started. There is no need to wait for the software to complete the expected time before proceeding to the next step, thereby improving the preparation efficiency of the first reagent.

[0055] In one embodiment, the first quantitative system 100 further includes a first liquid flow control component 140. Under the control of the controller, the first liquid flow control component 140 performs the following actions: controlling the first infusion line 120 to deliver the first liquid to the first quantitative tank 110; controlling the first infusion line 120 to stop delivering the first liquid to the first quantitative tank 110; controlling the first drainage line 130 to discharge the first liquid from the first quantitative tank 110 into the first mixing container 300; and controlling the first drainage line 130 to stop discharging the first liquid into the first mixing container 300. In this embodiment, the controller controls the operation of the first liquid flow control component 140 to achieve the function of automatically quantitatively dispensing the first liquid in the first quantitative system 100. This improves the intelligence and automation level of the reagent preparation device 10, thereby reducing the operator's workload and preventing human error from affecting the accuracy of the first reagent preparation.

[0056] In one embodiment, the first metering system 100 further includes a second liquid flow control component 190. Under the control of the controller, the second liquid flow control component 190 performs the following actions: controlling the second infusion line 180 to deliver the second liquid to the first metering tank 110; controlling the second infusion line 180 to stop delivering the second liquid to the first metering tank 110; controlling the first drainage line 130 to discharge the second liquid from the first metering tank 110 into the first mixing container 300; and controlling the first drainage line 130 to stop discharging the second liquid into the first mixing container 300. In this embodiment, the controller controls the operation of the second liquid flow control component 190 to achieve the function of automatically metering the second liquid in the first metering system 100.

[0057] The first liquid flow control component 140 and the second liquid flow control component 190 are set up on the same principle. The following description takes the first liquid flow control component 140 as an example and will not go into detail about the setting scheme of the second liquid flow control component 190.

[0058] In one implementation, the first liquid flow control assembly 140 includes a first power component 141 and a first valve assembly 142. Correspondingly, the second liquid flow control assembly 190 may include a second power component and a second valve assembly 191. The first power component 141 is used to drive the first liquid from the first infusion pipeline 120 into the first metering tank 110, and to drive the first liquid from the first metering tank 110 out and from the first drain pipeline 130 to the first mixing container 300. The first valve assembly 142 is used to control the opening and closing of the pipeline. The first power component 141 provides power for the flow of the first liquid, thereby helping to ensure the smoothness of the first liquid flow and avoiding the influence of positional limitations on the flow of the first liquid. Of course, in specific applications, as an alternative implementation, the first power component 141 may not be provided, and the first liquid may automatically flow from the component at the higher position to the component at the lower position through high and low position settings.

[0059] In one embodiment, the first power component 141 includes a first driving component 1411 and a second driving component 1412. When measuring the first liquid, the first driving component 1411 provides driving force for the first liquid to enter the first metering tank 110 from the first infusion line 120, and the second driving component 1412 provides driving force for the first liquid to be discharged from the first metering tank 110 and transported to the first mixing container 300. In this embodiment, the first driving component 1411 and the second driving component 1412 are two independent components. The first driving component 1411 is a negative pressure device capable of generating negative pressure, connected to the first metering tank 110, which can create a negative pressure environment in the first metering tank 110, thereby drawing the first liquid from the first infusion line 120 into the first metering tank 110. The second driving component 1412 is a positive pressure device capable of generating positive pressure, connected to the first metering tank 110, which can create a positive pressure environment in the first metering tank 110, thereby driving the first liquid in the first metering tank 110 to be discharged into the first mixing container 300. In this embodiment, the reagent preparation device 10 drives the input and output of the first liquid in the first metering pool 110 through a gas path system; of course, in specific applications, as an alternative embodiment, the reagent preparation device 10 can also drive the input and output of the first liquid in the first metering pool 110 through a liquid pump or a syringe.

[0060] In one embodiment, the second power unit includes a fourth drive unit for providing driving force for the second liquid to be input into the second metering container from the second infusion line 180 and a fifth drive unit for driving the second liquid to be discharged from the second metering container and transported from the second drain line to the first mixing container 300.

[0061] In a preferred embodiment, the second power component and the first power component 141 are the same device; that is, the first drive component 1411 and the fourth drive component are the same negative pressure device, and the second drive component 1412 and the fifth drive component are the same positive pressure device. In other words, the negative pressure device connected to the first metering container and the negative pressure device connected to the second metering container are the same device, and the positive pressure device connected to the first metering container and the positive pressure device connected to the second metering container are the same device. This simplifies the power system of the reagent preparation device 10, thereby reducing the cost and size of the reagent preparation device 10. Of course, in specific applications, as an alternative embodiment, the second power component and the first power component 141 can also be different devices. For example, as an alternative embodiment, the reagent preparation device 10 can also use a liquid pump or syringe to drive the input and output of the second liquid into the first metering tank 110.

[0062] In a preferred embodiment of this invention, the first valve assembly 142 includes a first reversing air valve 1421. The positive pressure device and the negative pressure device are connected to the first metering reservoir 110 via the first reversing air valve 1421. In this embodiment, the first reversing air valve 1421 is a two-position three-way valve with two working positions. In one working position, the negative pressure device is connected to the first metering reservoir 110; in the other working position, the positive pressure device is connected to the first metering reservoir 110. When the reagent preparation device 10 is in standby mode, the negative pressure device and the first metering reservoir 110 are normally connected, meaning the first metering reservoir 110 is under negative pressure. Of course, in specific applications, the valve configuration between the positive pressure device, the negative pressure device, and the first metering reservoir 110 is not limited to this. For example, as an alternative embodiment, the positive pressure device and the negative pressure device can also be connected to the first metering reservoir 110 via two separate switching air valves.

[0063] In one embodiment, the first valve assembly 142 further includes a first on / off liquid valve 1422, and the second valve assembly 191 further includes a second on / off liquid valve 1911. Specifically, the first liquid supply device 20 is connected to the first metering tank 110 via a first infusion line 120, and the first infusion line 120 is equipped with the first on / off liquid valve 1422; the second liquid supply device 30 is connected to the first metering tank 110 via a second infusion line 180, and the second infusion line 180 is equipped with the second on / off liquid valve 1911. The first liquid supply device 20 is used to supply pure water filtered by a reverse osmosis membrane to the first infusion line 120, and the second liquid supply device 30 is used to supply the first reagent stock solution to the second infusion line 180. The second liquid supply device 30 can be a reagent stock solution storage tank formed within the reagent preparation device 10 or a reagent stock solution tank independent of the reagent preparation device 10. The first liquid supply device 20 can be a pure water storage tank or a water supply pipe equipped with a reverse osmosis membrane.

[0064] In specific applications, when the first switch liquid valve 1422 is opened, since the first reversing air valve 1421 is in the state of normally conducting negative pressure device and first metering pool 110, the pure water in the first liquid supply device 20 can be transported to the first metering pool 110 through the first liquid delivery pipeline 120 under the suction of negative pressure. When the pure water measured in the first metering pool 110 reaches a certain amount, the first switch liquid valve 1422 is closed, which can control the first liquid delivery pipeline 120 to stop supplying pure water to the first metering pool 110.

[0065] When the second liquid valve 1911 is opened, since the first reversing valve 1421 is in the state of normally conducting negative pressure device and first metering pool 110, the first reagent stock solution in the second liquid supply device 30 can be transported to the first metering pool 110 through the second liquid delivery pipeline 180 under the suction action of negative pressure. When the first reagent stock solution measured in the first metering pool 110 reaches the amount required for the quantitative preparation of the first reagent in one operation, the second liquid valve 1911 is closed, which controls the second liquid delivery pipeline 180 to stop supplying the first reagent stock solution to the first metering pool 110.

[0066] In one embodiment, the first valve assembly 142 further includes a first drain valve 1423, and the first drain pipeline 130 between the first metering tank 110 and the first mixing container 300 is controlled by the first drain valve 1423. In specific applications, when the first drain valve 1423 is opened and the first reversing valve 1421 is switched to the state of conducting the positive pressure device and the first metering tank 110, the pure water or the first reagent stock solution in the first metering tank 110 can be transported to the first mixing container 300 under the action of positive pressure; when the pure water or the first reagent stock solution in the first metering tank 110 is drained, the first drain valve 1423 is closed and the first reversing valve 1421 is switched to the state of conducting the negative pressure device and the first metering tank 110.

[0067] Specifically, the controller mainly controls the infusion action of the first infusion line 120, the infusion action of the second infusion line 180, and the drainage action of the first drainage line 130 by controlling the actions of the first valve assembly 142 and the second valve assembly 191. In this embodiment, the first switching valve 1422, the second switching valve 1911, the first reversing air valve 1421, and the first drainage valve 1423 are all controlled by the controller. The controller improves the intelligence and automation of the reagent preparation device 10, thereby reducing the operator's workload and preventing human error from affecting the accuracy of the first reagent preparation.

[0068] The reagent preparation device 10 provided in this embodiment eliminates the need for repeated pressure switching and valve switching steps in the quantitative determination of the second liquid, saving time in the quantitative determination process of the second liquid and improving the efficiency of the first reagent preparation.

[0069] Furthermore, this embodiment also provides a sample analysis system, which includes at least one sample processing device and the aforementioned reagent preparation device 10. The reagent preparation device 10 is used to deliver a first reagent, prepared by mixing in a first mixing container 300, to the sample processing device. The first mixing container 300 is connected to the sample processing device via a pipeline. The sample processing device is used to perform at least one test on the sample. The sample processing device can be a blood cell analyzer, a biochemical immunoassay analyzer, or a coagulation analyzer, etc. The sample analysis system provided in this embodiment improves the preparation efficiency of the first reagent by employing the aforementioned reagent preparation device 10.

[0070] In one implementation, a first buffer container 50 is provided between the first mixing container 300 and the sample processing device. The first buffer container 50 is used to buffer a certain amount of the first reagent. In specific applications, a certain amount of the first reagent can be stored in the first buffer container 50 to ensure that the first reagent can be delivered to the sample processing device simultaneously through the first buffer container 50 during the preparation of the first reagent, thereby facilitating the continuous and stable operation of the sample processing system.

[0071] As a preferred embodiment of this invention, the sample analysis system includes a first sample processing device 40, which uses a first reagent, and a first buffer container 50 is connected between the first mixing container 300 and the first sample processing device 40 via a pipeline.

[0072] Furthermore, this embodiment also provides a reagent preparation method, which includes: controlling the first metering cell 110 to measure the second liquid in one go and deliver it to the first mixing container 300, and controlling the first metering cell 110 to measure the first liquid in (N-1) portions and deliver it to the first mixing container 300; mixing the first liquid measured by the first metering cell 110 and the second liquid in the first mixing container 300 to prepare the first reagent. The method for preparing the first reagent provided in this embodiment eliminates the need for repeated measurement of the second liquid, thus improving the efficiency of the first reagent preparation.

[0073] As a preferred embodiment of this invention, the process of preparing the first reagent includes:

[0074] 1) Standby state: The first switching liquid valve 1422, the second switching liquid valve 1911 and the first drain valve 1423 are all closed. The first reversing air valve 1421 is in the state of being connected to the negative pressure device and the first metering tank 110. The inside of the first metering tank 110 is in a negative pressure environment.

[0075] 2) Second liquid inlet action: Control the second switch liquid valve 1911 to open, and the first reagent stock solution is drawn into the first metering pool 110 by negative pressure; until the first reagent stock solution in the first metering pool 110 reaches the specified liquid level, the liquid level signal is fed back to the controller, and the controller controls the second switch liquid valve 1911 to close, stopping the delivery of the first reagent stock solution to the first metering pool 110.

[0076] 3) Second liquid discharge action: Control the first reversing valve 1421 to switch the first metering tank 110 to the state of being connected to the positive pressure device, and control the first discharge valve 1423 to open. The first reagent stock solution is driven by positive pressure to discharge from the first metering tank 110 and be transported to the first mixing container 300. Until the first metering tank 110, the first discharge pipeline 130, and the first discharge valve 1423 are emptied, control the first discharge valve 1423 to close, and the discharge of the first metering tank 110 stops.

[0077] 4) First liquid inlet action: Control the first reversing air valve 1421 to switch to the state where the first metering tank 110 is connected to the negative pressure device, control the first switch liquid valve 1422 to open, and pure water begins to be drawn into the first metering tank 110 by negative pressure; until the pure water entering the first metering tank 110 reaches the specified liquid level, the liquid level signal is fed back to the controller, and the controller controls the first switch liquid valve 1422 to close, stopping the delivery of pure water to the first metering tank 110;

[0078] 5) First liquid discharge action: Control the first reversing air valve 1421 to switch the first metering tank 110 to the state of being connected to the positive pressure device, and control the first discharge valve 1423 to open. Pure water begins to be discharged from the first metering tank 110 by positive pressure and transported to the first mixing container 300; until the first metering tank 110, the first discharge pipeline 130, and the first discharge valve 1423 are emptied, control the first discharge valve 1423 to close, and the discharge of the first metering tank 110 stops.

[0079] 6) Repeat steps 4) and 5) until the required number of times the pure water is quantified is reached. For example, if the second liquid is an N-fold concentrated reagent, the number of times the pure water is quantified is (N-1).

[0080] Example 2:

[0081] Reference Figures 1 to 4As shown, the reagent preparation device 10 and sample analysis system provided in this embodiment differ from those in Embodiment 1 mainly in that, in this embodiment, when the infusion line delivers liquid to the quantitative container, the infusion rate is adjustable. That is, the first liquid flow control component 140 is also used to perform the following actions under the control of the controller: regulating the flow rate of the first liquid delivered from the first infusion line 120 into the first quantitative pool 110; and / or, the second liquid flow control component 190 is also used to perform the following actions under the control of the controller: regulating the flow rate of the second liquid delivered from the second infusion line 180 into the first quantitative pool 110.

[0082] In this embodiment, the first liquid flow control component 140 regulates the flow rate of the first liquid delivered from the first infusion line 120 into the first metering tank 110, and the second liquid flow control component 190 regulates the flow rate of the second liquid delivered from the second infusion line 180 into the first metering tank 110. This allows for easy adjustment of the metering speed of the first and second liquids according to actual needs, thereby facilitating a comprehensive balance between metering efficiency and accuracy. As a preferred embodiment, the first liquid flow control component 140 can regulate the flow rate of the first liquid delivered from the first infusion line 120 into the first metering tank 110, and the second liquid flow control component 190 can regulate the flow rate of the second liquid delivered from the second infusion line 180 into the first metering tank 110. Thus, the metering speed of each liquid is adjustable. Alternatively, in specific applications, one of the first and second liquids can have an adjustable flow rate when delivered into the first metering tank 110, while the other can have an adjustable flow rate when delivered into the first metering tank 110. The flow rate is not adjustable. For example, the first liquid flow control component 140 can regulate the flow rate of the first liquid delivered from the first infusion line 120 into the first metering tank 110, while the second liquid flow control component 190 cannot regulate the flow rate of the second liquid delivered from the second infusion line 180 into the first metering tank 110; or, the first liquid flow control component 140 cannot regulate the flow rate of the first liquid delivered from the first infusion line 120 into the first metering tank 110, while the second liquid flow control component 190 can regulate the flow rate of the second liquid delivered from the second infusion line 180 into the first metering tank 110.

[0083] In one implementation, the controller is configured to: during the measurement of the first liquid, control the first liquid flow control component 140 to regulate the first infusion line 120 to deliver the first liquid into the first metering tank 110 at at least two different flow rates, and control the first liquid flow control component 140 to regulate the flow rate of the first liquid delivered into the first metering tank 110 to change sequentially from large to small. Because there is a response time difference between the control command issued by the controller to stop supplying the first liquid to the first metering tank 110 and the stopping of the first liquid supply, if the first liquid is supplied into the first metering tank 110 at a high flow rate throughout the measurement process, the measurement accuracy of the first liquid will be low. This is because although a high flow rate can make the measurement speed of the first liquid faster, the faster the flow rate, the larger the volume of liquid supplied during the response time difference, and the larger the error, which will seriously affect the preparation accuracy of the first reagent. On the other hand, if the first liquid is supplied into the first metering tank 110 at a low flow rate throughout the process, the measurement speed of the first liquid will be reduced. This is because although a low flow rate can reduce the error in measurement accuracy, the measurement time will be extended, which will seriously affect the preparation efficiency of the first reagent. This implementation scheme controls and regulates the flow rate of the first liquid into the first metering tank 110, changing it sequentially from high to low. In this way, in the initial stage of measuring the first liquid, a high flow rate can be used to ensure the efficiency of the first liquid measurement; while in the later stage of the first liquid measurement, a low flow rate can be used to ensure the accuracy of the first liquid measurement, thus comprehensively taking into account both high efficiency and high accuracy of the first liquid measurement.

[0084] In one implementation, the controller is configured to: during the measurement of the second liquid, control the second liquid flow control component 190 to regulate the second infusion line 180 to deliver the second liquid into the first metering tank 110 at at least two different flow rates, and control the second liquid flow control component 190 to regulate the flow rate of the second liquid delivered into the first metering tank 110 to change sequentially from high to low. The metering speed regulation principle of the second liquid is the same as that of the first liquid, and will not be described in detail here.

[0085] In one implementation, the controller is further configured to: during the process of the first metering system 100 measuring the first liquid, control the first liquid flow control component 140 to regulate the first infusion line 120 to first deliver the first liquid into the first metering tank 110 at a first flow rate, and then deliver the first liquid into the first metering tank 110 at a second flow rate, wherein the first flow rate is greater than the second flow rate. In this embodiment, the first liquid is first delivered into the first metering tank 110 at a higher flow rate, and then delivered into the first metering tank 110 at a lower flow rate, which is beneficial to ensuring both high-efficiency and high-precision measurement of the first liquid. Of course, in specific applications, as an alternative implementation, the controller can also be configured to control the first liquid to be delivered into the first metering tank 110 at three or more flow rates.

[0086] In one implementation, the controller is further configured to: during the process of the first metering system 100 measuring the second liquid, control the second liquid flow control component 190 to regulate the second infusion line 180 to first deliver the second liquid into the first metering tank 110 at a third flow rate, and then deliver the second liquid into the first metering tank 110 at a fourth flow rate, wherein the third flow rate is greater than the fourth flow rate. In this embodiment, the second liquid is first delivered into the first metering tank 110 at a higher flow rate, and then delivered into the first metering tank 110 at a lower flow rate, which is beneficial for ensuring both high-efficiency and high-precision measurement of the second liquid. Of course, in specific applications, as an alternative implementation, the controller can also be configured to control the second liquid to be delivered into the first metering tank 110 at three or more flow rates.

[0087] In one implementation, the controller is configured to: during the process of delivering the first liquid from the first infusion line 120 to the first metering tank 110, control the first liquid flow control component 140 to operate according to the liquid level in the first metering tank 110, thereby regulating the flow rate of the first liquid entering the first metering tank 110 and controlling the first infusion line 120 to stop delivering the first liquid into the first metering tank 110. Specifically, before the liquid level in the first metering tank 110 reaches a certain preset position, the first liquid is delivered into the first metering tank 110 at a certain speed; when the liquid level in the first metering tank 110 reaches the certain preset position, the first liquid flow control component 140 regulates the first liquid to be delivered into the first metering tank 110 at another speed; when the liquid level in the first metering tank 110 reaches another preset position, the first liquid flow control component 140 controls the infusion line to stop delivering liquid into the first metering tank 110. Similarly, the controller can also regulate the delivery of the second liquid according to the liquid level in the first metering tank 110. Specifically, the controller can also be configured to: during the process of the second infusion line 180 delivering the second liquid to the first metering pool 110, control the second liquid flow control component 190 to operate according to the liquid level in the first metering pool 110, so as to regulate the flow rate of the second liquid delivered into the first metering pool 110 and control the second infusion line 180 to stop delivering the second liquid into the first metering pool 110.

[0088] In one implementation, the controller is configured to: during the process of delivering the first liquid from the first infusion line 120 to the first metering tank 110, when the liquid level in the first metering tank 110 is lower than the first liquid level, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a first flow rate; when the liquid level in the first metering tank 110 is equal to or higher than the first liquid level and lower than the second liquid level, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a second flow rate; when the liquid level in the first metering tank 110 is equal to the second liquid level, control the first liquid flow control component 140 to act to stop delivering the first liquid into the first metering tank 110; wherein the first liquid level is lower than the second liquid level, and the first flow rate is greater than the second flow rate. In this implementation scheme, when the liquid level is low, the first liquid is delivered into the first metering tank 110 at a higher flow rate; when the liquid level is high, the first liquid is delivered into the first metering tank 110 at a lower flow rate. This is beneficial to ensuring both the high efficiency and high accuracy of the first liquid measurement.

[0089] In one implementation, the controller can also be configured to: during the process of delivering the second liquid from the second infusion line 180 to the first metering tank 110, when the liquid level in the first metering tank 110 is lower than the third liquid level, control the second liquid flow control component 190 to regulate the second liquid to be delivered into the first metering tank 110 at a third flow rate; when the liquid level in the first metering tank 110 is equal to or higher than the third liquid level and lower than the fourth liquid level, control the second liquid flow control component 190 to regulate the second liquid to be delivered into the first metering tank 110 at a fourth flow rate; when the liquid level in the first metering tank 110 is equal to the fourth liquid level, control the second liquid flow control component 190 to stop delivering the second liquid into the first metering tank 110; wherein the third liquid level is lower than the fourth liquid level, and the third flow rate is greater than the fourth flow rate.

[0090] In one embodiment, the first metering system 100 further includes a first liquid level detection component 150 and a second liquid level detection component 160; the first liquid level detection component 150 is used to detect whether the liquid level in the first metering tank 110 has reached a first liquid level; the second liquid level detection component 160 is used to detect whether the liquid level in the first metering tank 110 has reached a second liquid level; the controller is configured to control the first liquid flow control component 140 to operate based on the feedback information from the first liquid level detection component 150 and the second liquid level detection component 160. Specifically, the controller is configured to: during the process of delivering the first liquid from the first infusion line 120 to the first metering tank 110, when the liquid level in the first metering tank 110 is determined to be lower than the first liquid level based on feedback information from the first liquid level detection component 150, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a first flow rate; when the liquid level in the first metering tank 110 is determined to be equal to or higher than the first liquid level and lower than the second liquid level based on feedback information from the first liquid level detection component 150 and the second liquid level detection component 160, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a second flow rate; when the liquid level in the first metering tank 110 is determined to be equal to the second liquid level based on feedback information from the second liquid level detection component 160, control the first liquid flow control component 140 to operate to control the first infusion line 120 to stop delivering the first liquid into the first metering tank 110. In this embodiment, the liquid level at different locations in the first metering tank 110 is monitored by the first liquid level detection component 150 and the second liquid level detection component 160, and the detection information is fed back to the controller so that the controller can control the first liquid flow control component 140 to work according to the liquid level in the first metering tank 110.

[0091] In one implementation, the controller is further configured to: during the process of the second infusion line 180 delivering the second liquid to the first metering tank 110, when the feedback information from the first liquid level detection component 150 determines that the liquid level in the first metering tank 110 is lower than the first liquid level, control the second liquid flow control component 190 to regulate the second liquid to be delivered into the first metering tank 110 at a third flow rate; when the feedback information from the first liquid level detection component 150 and the second liquid level detection component 160 determines that the liquid level in the first metering tank 110 is equal to or higher than the first liquid level and lower than the second liquid level, control the second liquid flow control component 190 to regulate the second liquid to be delivered into the first metering tank 110 at a fourth flow rate; when the feedback information from the second liquid level detection component 160 determines that the liquid level in the first metering tank 110 is equal to the second liquid level, control the second liquid flow control component 190 to operate to control the second infusion line 180 to stop delivering the second liquid into the first metering tank 110; wherein the first liquid level is lower than the second liquid level, and the third flow rate is greater than the fourth flow rate.

[0092] In one embodiment, the first liquid level detection component 150 includes at least one of an electrode group, a capacitive sensor, an optocoupler detector, and an ultrasonic detector. In a preferred embodiment, the first liquid level detection component 150 is an electrode group, comprising two first electrodes 151 spaced horizontally and connected to a controller. When the liquid (first liquid or second liquid) in the first metering tank 110 does not reach the height position of the first liquid level detection component 150, the circuit formed by the two first electrodes 151 and the controller is disconnected. When the liquid in the first metering tank 110 reaches the height position of the first liquid level detection component 150, the liquid conducts through the two first electrodes 151, forming a closed circuit with the controller. Upon receiving the current signal from the first electrodes 151, the controller determines that the liquid level in the first metering tank 110 has reached the first liquid level and controls the switching action of the liquid flow rate.

[0093] In one embodiment, the second liquid level detection component 160 includes at least one of an electrode group, a capacitive sensor, an optocoupler detector, and an ultrasonic detector. In a preferred embodiment, the second liquid level detection component 160 is an electrode group, comprising two horizontally spaced second electrodes 161 respectively connected to a controller. When the liquid in the first metering tank 110 has not reached the height position of the second liquid level detection component 160, the circuit formed between the two second electrodes 161 and the controller is disconnected. When the liquid in the first metering tank 110 reaches the height position of the second liquid level detection component 160, the liquid conducts through the two second electrodes 161, forming a closed circuit with the controller. Upon receiving the current signal from the second electrodes 161, the controller determines that the liquid level in the first metering tank 110 has reached the second liquid level and controls the cessation of liquid delivery to the first metering tank 110.

[0094] In one implementation, the second liquid level is level with the liquid level of the first metering tank 110 corresponding to the required amount of the second liquid in the preparation of the first reagent in one step. In specific applications, during the metering of the second liquid, when the liquid level in the first metering tank 110 reaches the second liquid level, it indicates that the amount of the second liquid measured by the first metering tank 110 has reached the predetermined value, and at this time, the flow of liquid into the first metering tank 110 is stopped.

[0095] Specifically, the first liquid flow control component 140 includes a speed regulating component for regulating the flow rate and / or pressure of the first liquid in the first infusion line 120. That is, the first liquid flow control component 140 may include a component for controlling the flow rate of the first liquid in the first infusion line 120, or the first liquid flow control component 140 may also include a component for controlling the pressure of the first liquid in the first infusion line 120, or the first liquid flow control component 140 may simultaneously include a component for controlling the flow rate of the first liquid in the first infusion line 120 and a component for controlling the pressure of the first liquid in the first infusion line 120. The arrangement of the second liquid flow control component 190 can be referred to that of the first liquid flow control component 140, and will not be described in detail here.

[0096] In one embodiment, the first infusion line 120 includes at least two first input branches 121 connected in parallel between the first metering tank 110 and the first supply device 20. The first valve assembly 142 includes a first infusion control valve group for controlling the on / off state of each first input branch 121 between the first metering tank 110 and the first supply device 20. In this embodiment, the first liquid flow control assembly 140 controls the flow rate of the first liquid in the first infusion line 120. In specific applications, the first valve assembly 142 can control the first supply device 20 to supply liquid to the first metering tank 110 through different first input branches 121, thereby controlling the flow rate of the first liquid supplied by the first supply device 20 to the first metering tank 110, and thus achieving the purpose of controlling the flow rate of the first liquid entering the first metering tank 110.

[0097] In one embodiment, the first infusion control valve group includes at least two on / off valves (e.g., the third on / off valve 1424 and the fourth on / off valve 1425 in this embodiment) respectively disposed on each of the first input branches 121 for controlling the on / off state of the first input branches 121. By controlling the on / off state of each on / off valve on each of the first input branches 121, the first infusion supply device 20 can be effectively controlled to deliver infusion to the first metering tank 110 through different first input branches 121. In specific applications, when it is necessary to control the first liquid supply device 20 to deliver the first liquid into the first metering tank 110 at the maximum flow rate, the switching liquid valves on each of the first input branches 121 are controlled to be in the open state; when it is necessary to control the first liquid supply device 20 to deliver the first liquid into the first metering tank 110 at a lower flow rate, the switching liquid valve on at least one input branch is controlled to be in the open state, and the switching liquid valve on at least one of the first input branches 121 is controlled to be in the closed state; when it is necessary to control the first liquid supply device 20 to stop delivering the first liquid into the first metering tank 110, the switching liquid valves on each of the first input branches 121 are controlled to be in the closed state. Of course, in specific applications, the configuration of the first infusion control valve group is not limited to this. For example, as an alternative implementation, the first infusion control valve group includes a reversing valve and a switching valve. The first infusion pipeline 120 includes a first main branch and / or a second main branch. One end of the first main branch is connected to the first infusion supply device 20, and the other end is connected to each of the first input branches 121. One end of the second main branch is connected to the first metering tank 110, and the other end is connected to each of the first input branches 121. Each of the first input branches 121 is connected to the first main branch or the second main branch through the reversing valve. The first main branch and / or the second main branch are equipped with switching valves. In this alternative implementation, the combination of the reversing valve and the switching valve can also achieve the purpose of controlling the first infusion supply device 20 to deliver liquid to the first metering tank 110 through different first input branches 121.

[0098] In one implementation, at least one first input branch 121 is provided with a throttling device 1426. The throttling device 1426 can be used to further assist in regulating the flow rate of the first liquid in the first input branch 121, thereby reducing the flow rate of the first liquid without reducing the diameter of the first input branch 121. The throttling device 1426 can be a throttling valve or a capillary tube.

[0099] In a preferred embodiment of this invention, the first infusion line 120 includes two first input branches 121 connected in parallel between the first metering tank 110 and the first infusion supply device 20. The first infusion control valve group includes a third switching valve 1424 and a fourth switching valve 1425. Specifically, one first input branch 121 is equipped with the third switching valve 1424, and the other first input branch 121 is equipped with the fourth switching valve 1425 and a throttling device 1426.

[0100] In one embodiment, the second infusion line 180 includes at least two second input branches connected in parallel between the first metering tank 110 and the second supply device 30. The second valve assembly 191 includes a fourth infusion control valve group for controlling the on / off state of each second input branch between the first metering tank 110 and the second supply device 30. The second infusion line 180 and the second liquid flow control assembly 190 can be configured with reference to the first infusion line 120 and the first liquid flow control assembly 140 described above, and will not be described in detail here.

[0101] The method for preparing the first reagent provided in this embodiment differs from that in Embodiment 1 in that: in this embodiment, the method of measuring the first liquid in the first metering cell 110 includes: first controlling the first liquid to be fed into the first metering cell 110 at a first flow rate, and then controlling the first liquid to be fed into the first metering cell 110 at a second flow rate, wherein the first flow rate is greater than the second flow rate. The method of measuring the second liquid in the first metering cell 110 includes: first controlling the second liquid to be fed into the first metering cell 110 at a third flow rate, and then controlling the second liquid to be fed into the first metering cell 110 at a fourth flow rate, wherein the third flow rate is greater than the fourth flow rate.

[0102] As a preferred embodiment of this example, the method by which the first metering system 100 measures the first liquid includes: monitoring the liquid level of the first liquid in the first metering pool 110; if the liquid level in the first metering pool 110 is lower than the first liquid level, then controlling the first liquid to be delivered into the first metering pool 110 at a first flow rate; if the liquid level in the first metering pool 110 is equal to or higher than the first liquid level and lower than the second liquid level, then controlling the first liquid to be delivered into the first metering pool 110 at a second flow rate; if the liquid level in the first metering pool 110 is equal to the second liquid level, then controlling the stopping of the delivery of the first liquid into the first metering pool 110. The method by which the first metering system 100 measures the second liquid includes: monitoring the liquid level of the second liquid in the first metering pool 110; if the liquid level in the first metering pool 110 is lower than the third liquid level, then controlling the second liquid to be delivered into the first metering pool 110 at a third flow rate; if the liquid level in the first metering pool 110 is equal to or higher than the third liquid level and lower than the fourth liquid level, then controlling the second liquid to be delivered into the first metering pool 110 at a fourth flow rate; if the liquid level in the first metering pool 110 is equal to the fourth liquid level, then controlling the stopping of the delivery of the second liquid into the first metering pool 110.

[0103] The following example, using the process of metering pure water (metering the first liquid in the first metering tank 110) to illustrate the metering process of liquid:

[0104] 1) Standby state: The third liquid switch valve 1424, the fourth liquid switch valve 1425, and the first drain valve 1423 are all closed. The first reversing air valve 1421 is in a state of negative pressure device and conduction with the first metering tank 110. The inside of the first metering tank 110 is in a negative pressure environment.

[0105] 2) Liquid delivery to the first metering tank 110: The third and fourth switching valves 1424 and 1425 are opened to allow pure water to flow into the first metering tank 110 at a first flow rate. When the liquid surface in the first metering tank 110 contacts the first level detection component 150, the first level detection component 150 feeds back the level signal to the controller. The controller then closes the third switching valve 1424 while keeping the fourth switching valve 1425 open, allowing pure water to flow into the first metering tank 110 at a second flow rate. When the liquid surface in the first metering tank 110 contacts the second level detection component 160, the second level detection component 160 feeds back the level signal to the controller. The controller then closes the fourth switching valve 1425 to stop the delivery of pure water to the first metering tank 110.

[0106] 3) Drainage action of the first metering tank 110: Control the first reversing air valve 1421 to switch the first metering tank 110 to the state of being connected to the positive pressure device, and control the first drain valve 1423 to open. Pure water begins to be driven by positive pressure to drain from the first metering tank 110 and be transported to the first mixing container 300. Until the first metering tank 110 is emptied, control the first drain valve 1423 to close, and control the first reversing air valve 1421 to switch the first metering tank 110 to the state of being connected to the negative pressure device. Drainage of the first metering tank 110 stops.

[0107] Apart from the differences mentioned above, the reagent preparation device 10 and other parts of the sample analysis system provided in this embodiment can be optimized and set up in accordance with the corresponding embodiment 1, and will not be described in detail here.

[0108] Example 3:

[0109] Reference Figure 1 , Figure 4 and Figure 5 As shown, the reagent preparation apparatus 10 and sample analysis system provided in this embodiment differ from those in Embodiment 2 mainly in that the basis for the controller to control the operation of the first liquid flow control component 140 and / or the second liquid flow control component 190 is different. Specifically, in Embodiment 2, the controller is configured to control the operation of the first liquid flow control component 140 based on the liquid level in the first metering tank 110, and to control the operation of the second liquid flow control component 190 based on the liquid level in the first metering tank 110. In this embodiment, the controller is configured to control the operation of the first liquid flow control component 140 based on the liquid level in the first metering tank 110 and the time it takes for the first infusion line 120 to deliver the first liquid to the first metering tank 110; and / or, the controller is configured to control the operation of the second liquid flow control component 190 based on the liquid level in the first metering tank 110 and the time it takes for the second infusion line 180 to deliver the second liquid to the first metering tank 110.

[0110] Specifically, in this embodiment, before the time for supplying the first liquid to the first metering tank 110 reaches a certain preset time, the first liquid is supplied to the first metering tank 110 at a certain speed; after the time for supplying the first liquid to the first metering tank 110 reaches the certain preset time, but before the liquid level reaches a certain preset position, the first liquid flow control component 140 regulates the first liquid to be supplied to the first metering tank 110 at another speed. Before the time for supplying the second liquid to the first metering tank 110 reaches the certain preset time, the second liquid is supplied to the first metering tank 110 at a certain speed; after the time for supplying the second liquid to the first metering tank 110 reaches the certain preset time, but before the liquid level reaches a certain preset position, the second liquid flow control component 190 regulates the second liquid to be supplied to the first metering tank 110 at another speed.

[0111] In one implementation, the controller is configured to: during the process of the first infusion line 120 delivering the first liquid to the first metering tank 110, when the time for the first infusion line 120 to deliver the first liquid to the first metering tank 110 is less than a first preset time, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a first flow rate; when the time for the first infusion line 120 to deliver the first liquid to the first metering tank 110 is greater than or equal to the first preset time, and the liquid level in the first metering tank 110 is lower than a second liquid level, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a second flow rate, wherein the first flow rate is greater than the second flow rate. In this implementation scheme, during the initial period of supplying the first liquid to the first metering tank 110, the first liquid is first supplied to the first metering tank 110 at a relatively high flow rate; after the first liquid is supplied to the first metering tank 110 at a relatively high first flow rate for a period of time, the flow rate is switched to a relatively low second flow rate to supply the first liquid to the first metering tank 110. This can simultaneously ensure both high-efficiency and high-precision measurement of the first liquid.

[0112] In one implementation, the first metering system 100 further includes a first timing component (not shown) and a second liquid level detection component 160. The first timing component is used to calculate the time for the first infusion line 120 to deliver the first liquid into the first metering tank 110, and the second liquid level detection component 160 is used to detect whether the liquid level in the first metering tank 110 has reached a second liquid level. The controller is used to control the operation of the first liquid flow control component 140 based on the feedback information from the first timing component and the second liquid level detection component 160. Specifically, the controller is configured to: during the process of delivering the first liquid from the first infusion line 120 to the first metering tank 110, when, based on feedback information from the first timing component, it is determined that the time for the first liquid to be delivered from the first infusion line 120 to the first metering tank 110 is less than a first preset time, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a first flow rate; when, based on feedback information from the first timing component and the second liquid level detection component 160, it is determined that the time for the first liquid to be delivered from the first infusion line 120 to the first metering tank 110 is greater than or equal to the first preset time, and the liquid level in the first metering tank 110 is lower than a second liquid level, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a second flow rate. In this embodiment, the first timing component and the second liquid level detection component 160 monitor the amount of the first liquid input into the first metering tank 110 and feed the detection information back to the controller, so that the controller can control the operation of the first liquid flow control component 140.

[0113] As a preferred embodiment of this example, the method by which the first metering system 100 measures the first liquid includes: monitoring the time for the first infusion line 120 to deliver the first liquid into the first metering pool 110 and the liquid level of the first liquid in the first metering pool 110; if the time for the first infusion line 120 to deliver the first liquid into the first metering pool 110 is less than a first preset time, then controlling the first liquid to be delivered into the first metering pool 110 at a first flow rate; if the time for the first infusion line 120 to deliver the first liquid into the first metering pool 110 is greater than or equal to the first preset time and the liquid level in the first metering pool 110 is lower than a second liquid level, then controlling the first liquid to be delivered into the first metering pool 110 at a second flow rate; if the liquid level in the first metering pool 110 is equal to the second liquid level, then controlling the stopping of the delivery of the first liquid into the first metering pool 110.

[0114] In one implementation, the first timing component is further used to calculate the time for the second infusion line 180 to deliver the second liquid into the first metering tank 110, and the second liquid level detection component 160 is further used to detect whether the liquid level of the second liquid in the first metering tank 110 has reached a fourth liquid level. The controller is configured to: during the process of the second infusion line 180 delivering the second liquid into the first metering tank 110, when, based on feedback information from the first timing component, it is determined that the time for the second infusion line 180 to deliver the second liquid into the first metering tank 110 is less than a third preset time, control the second liquid flow control component 190 to regulate the second liquid to be delivered into the first metering tank 110 at a third flow rate; when, based on feedback information from the first timing component and the second liquid level detection component 160 ... When the time for the second liquid to flow is greater than or equal to a third preset time, and the liquid level in the first metering tank 110 is lower than the second liquid level, the second liquid flow control component 190 is controlled to regulate the second liquid to flow into the first metering tank 110 at a fourth flow rate. When the feedback information from the second liquid level detection component 160 determines that the liquid level in the first metering tank 110 is equal to the second liquid level, the second liquid flow control component 190 is controlled to stop the second liquid from flowing into the first metering tank 110 via the second infusion line 180. The third flow rate is greater than the fourth flow rate. The principle by which the controller regulates the second liquid delivery speed based on the first timing component and the second liquid level detection component 160 is the same as the principle by which the controller regulates the first liquid delivery speed based on the first timing component and the second liquid level detection component 160, and will not be described in detail here.

[0115] Apart from the differences mentioned above, the other parts of the reagent preparation device 10 and sample analysis system provided in this embodiment can be optimized by referring to any one of Embodiment 1 and Embodiment 2, and will not be described in detail here.

[0116] Example 4:

[0117] Reference Figure 1 and Figures 4 to 6 As shown, the reagent preparation device 10 and sample analysis system provided in this embodiment differ from those in Embodiments 2 and 3 mainly in that the basis for the controller to control the first liquid flow control component 140 and / or the second liquid flow control component 190 is different. Specifically, in Embodiments 2 and 3, the controller switches the infusion flow rate based on the liquid level or time, and controls the infusion pipeline to stop infusing liquid into the quantitative container based on the liquid level; however, in this embodiment, no liquid level detection component is provided, and the controller switches the infusion flow rate and controls the infusion pipeline to stop infusing liquid into the quantitative container based on time.

[0118] Specifically, in this embodiment, the controller is configured to: during the process of the first infusion line 120 delivering the first liquid to the first metering tank 110, control the first liquid flow control component 140 to operate according to the time of the first liquid delivery from the first infusion line 120 to the first metering tank 110, so as to regulate the flow rate of the first liquid entering the first metering tank 110 and control the first infusion line 120 to stop delivering the first liquid to the first metering tank 110; and / or, the controller is configured to: during the process of the second infusion line 180 delivering the second liquid to the first metering tank 110, control the second liquid flow control component 190 to operate according to the time of the second liquid delivery from the second infusion line 180 to the first metering tank 110, so as to regulate the flow rate of the second liquid entering the first metering tank 110 and control the second infusion line 180 to stop delivering the second liquid to the first metering tank 110.

[0119] In one implementation, the controller is configured to: during the process of the first infusion line 120 delivering the first liquid to the first metering tank 110, when the time for the first infusion line 120 to deliver the first liquid into the first metering tank 110 is less than a first preset time, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a first flow rate; when the time for the first liquid to be delivered into the first metering tank 110 by the first infusion line 120 is greater than or equal to the first preset time and less than a second preset time, control the first liquid flow control component 140 to regulate the first liquid to be delivered into the first metering tank 110 at a second flow rate, wherein the first flow rate is greater than the second flow rate. The first preset time is a preset time for flow rate switching, and the second preset time is a preset stop time for stopping the infusion. In this implementation scheme, during the initial period of infusing the first liquid into the first metering tank 110, the first liquid is first delivered into the first metering tank 110 at a relatively high first flow rate; after delivering the first liquid into the first metering tank 110 at a relatively high first flow rate for a period of time, the flow rate is switched to a relatively low second flow rate until a preset stop time is reached. This approach can simultaneously ensure both high-efficiency and high-precision measurement of the first liquid.

[0120] In one implementation, the first metering system 100 further includes a first timing component, which calculates the time for the first infusion line 120 to deliver the first liquid into the first metering tank 110. The controller is configured to: during the delivery of the first liquid from the first infusion line 120 to the first metering tank 110, if, based on feedback from the first timing component, the time for delivering the first liquid from the first infusion line 120 to the first metering tank 110 is less than a first preset time, control the first liquid flow control component 140 to regulate the first liquid flow into the first metering tank 110 at a first flow rate; if, based on feedback from the first timing component, the time for delivering the first liquid from the first infusion line 120 to the first metering tank 110 is greater than or equal to the first preset time and less than a second preset time, control the first liquid flow control component 140 to regulate the first liquid flow into the first metering tank 110 at a second flow rate. In this implementation, the first timing component monitors the amount of the first liquid entering the first metering tank 110 and feeds back the detection information to the controller, so that the controller can control the operation of the first liquid flow control component 140.

[0121] In one implementation, when the time for the first infusion line 120 to deliver the first liquid into the first metering tank 110 is equal to a second preset time, the liquid level of the first liquid in the first metering tank 110 is level with the liquid level corresponding to the required metered amount of first liquid in the first metering tank 110 during the preparation of the first reagent in one step. In specific applications, the value of the second preset time can be determined based on multiple experiments, so that when the time for the first infusion line 120 to deliver the first liquid into the first metering tank 110 is equal to the second preset time, the amount of first liquid measured by the first metering tank 110 reaches a predetermined value, at which point the infusion into the first metering tank 110 is stopped.

[0122] As a preferred embodiment of this example, the method by which the first quantitative system 100 measures the first liquid includes: monitoring the time for the first infusion line 120 to deliver the first liquid into the first quantitative pool 110; if the time for the first infusion line 120 to deliver the first liquid into the first quantitative pool 110 is less than a first preset time, then controlling the first liquid to be delivered into the first quantitative pool 110 at a first flow rate; if the time for the first infusion line 120 to deliver the first liquid into the first quantitative pool 110 is greater than or equal to the first preset time and less than a second preset time, then controlling the first liquid to be delivered into the first quantitative pool 110 at a second flow rate; if the time for the first infusion line 120 to deliver the first liquid into the first quantitative pool 110 is equal to the second preset time, then controlling the stopping of the delivery of the first liquid into the first quantitative pool 110.

[0123] In one implementation, the first timing component is also used to calculate the time for the second infusion line 180 to deliver the second liquid into the first metering tank 110; the controller is further configured to: during the process of the second infusion line 180 delivering the second liquid into the first metering tank 110, when, based on feedback information from the first timing component, it is determined that the time for the second infusion line 180 to deliver the second liquid into the first metering tank 110 is less than a third preset time, control the second liquid flow control component 190 to regulate the second liquid to be delivered into the first metering tank 110 at a third flow rate; ... When the time for delivering the second liquid into the first metering tank 110 is greater than or equal to a third preset time and less than a fourth preset time, the second liquid flow control component 190 is controlled to regulate the second liquid to be delivered into the first metering tank 110 at a fourth flow rate. When, based on feedback information from the first timing component, it is determined that the time for the second infusion line 180 to deliver the second liquid into the first metering tank 110 is equal to the fourth preset time, the second liquid flow control component 190 is controlled to stop the second infusion line 180 from delivering the second liquid into the first metering tank 110. The third preset time is less than the fourth preset time, and the third flow rate is greater than the fourth flow rate. The principle by which the controller controls the second liquid flow control component 190 based on the first timing component is the same as the principle by which the controller controls the first liquid flow control component 140 based on the first timing component, and will not be described in detail here.

[0124] The first and third preset times can be the same time or two different times. The second and fourth preset times can be the same time or two different times.

[0125] Apart from the differences mentioned above, the reagent preparation device 10, sample analysis system and other parts of the first reagent preparation method provided in this embodiment can be optimized according to any one of embodiments one to three, and will not be described in detail here.

[0126] Example 5:

[0127] Reference Figure 1 , Figure 4 and Figure 7As shown, the reagent preparation apparatus 10, sample analysis system, and first reagent preparation method provided in this embodiment differ from those in embodiments one to four, mainly in the timing of controlling the first infusion line 120 to stop supplying the first liquid to the first metering pool 110, and / or the timing of controlling the second infusion line 180 to stop supplying the second liquid to the first metering pool 110. Specifically, in embodiments one to four, the controller controls the first infusion line 120 to stop supplying the first liquid to the first metering pool 110 when the liquid level of the first liquid in the first metering pool 110 is equal to the liquid level of the second liquid required for the first reagent preparation in one step; and controls the second infusion line 180 to stop supplying the second liquid to the first metering pool 110 when the liquid level of the second liquid in the first metering pool 110 is equal to the liquid level of the second liquid required for the first reagent preparation in one step. In this embodiment, the controller controls the second infusion line 180 to stop supplying the second liquid when the liquid level of the first liquid in the first metering pool 110 is higher than the liquid level of the first liquid in the first metering pool 110. The first infusion line 120 stops supplying the first liquid to the first metering tank 110 only after the liquid level of the metering tank 110 exceeds the required level of the second liquid in the preparation of the first reagent. Then, the excess first liquid is discharged from the first metering tank 110 through the overflow port a. Or, the second infusion line 180 stops supplying the second liquid to the first metering tank 110 only after the liquid level of the second liquid in the first metering tank 110 exceeds the required level of the second liquid in the preparation of the first reagent. Then, the excess second liquid is discharged from the first metering tank 110 through the second overflow port a.

[0128] Specifically, in this embodiment, the first quantitative system 100 further includes an overflow pipe 170. An overflow port a is provided on the first quantitative pool 110. The overflow port a is flush with the liquid level corresponding to the required quantitative second liquid in the preparation of the first reagent in the first quantitative pool 110. One end of the overflow pipe 170 is connected to the overflow port a to discharge the liquid above the overflow port a in the first quantitative pool 110. The overflow port a is specifically formed on the side of the spout 112. In practical application, when the controller controls the first infusion pipe 120 to deliver the first liquid to the first quantitative pool 110, after the infusion is completed, the liquid level in the first quantitative pool 110 should be above the overflow port a. After the infusion is completed, the liquid below the overflow port a can be naturally discharged from the overflow port a until the liquid level in the first quantitative pool 110 is flush with the overflow port a, thereby achieving liquid level control of the quantitative first liquid in the first quantitative pool 110.

[0129] In a preferred embodiment of this invention, a second drain valve 171 is provided on the overflow pipe 170. The second drain valve 171 is a switch control valve that can control the opening and closing of the overflow pipe 170. The second drain valve 171 is normally closed. After the infusion is completed, the second drain valve 171 is opened to allow the liquid exceeding the overflow port a to be discharged naturally from the overflow port a until the liquid level in the first metering tank 110 is level with the overflow port a, and then the second drain valve 171 is closed.

[0130] In this embodiment, the controller can stop the infusion of the first liquid based on a second liquid level or a second preset time. Specifically, in the scheme where the controller stops the infusion based on the second liquid level, the second liquid level set by the second liquid level detection component 160 is higher than the liquid level corresponding to the required quantitative second liquid level in the first metering tank 110 during one preparation of the first reagent. In the scheme where the controller stops the infusion based on the second preset time, when the time for the first infusion line 120 to deliver the first liquid into the first metering tank 110 is equal to the second preset time, the liquid level of the first liquid in the first metering tank 110 is higher than the liquid level corresponding to the required quantitative first liquid level in the first metering tank 110 during one preparation of the first reagent.

[0131] In one implementation, the controller can stop the infusion of the second liquid based on a second liquid level or a fourth preset time. Specifically, in the scheme where the controller stops the infusion based on the second liquid level, the second liquid level set by the second liquid level detection component 160 is higher than the liquid level corresponding to the required quantitative amount of the second liquid in the first metering tank 110 during one preparation of the first reagent. In the scheme where the controller stops the infusion based on the fourth preset time, when the time for the second infusion line 180 to deliver the second liquid into the first metering tank 110 is equal to the fourth preset time, the liquid level of the second liquid in the first metering tank 110 is higher than the liquid level corresponding to the required quantitative amount of the second liquid in the first metering tank 110 during one preparation of the first reagent.

[0132] Apart from the differences mentioned above, the reagent preparation device 10 and other parts of the sample analysis system provided in this embodiment can be optimized according to any one of embodiments one to four, and will not be described in detail here.

[0133] Example 6:

[0134] Reference Figure 1 , Figure 4 and Figure 8As shown, the reagent preparation device 10 and sample analysis system provided in this embodiment differ from those in embodiments two to five mainly in the different flow control methods of the first infusion line 120 and / or the second infusion line 180. Specifically, in embodiment two, the first infusion line 120 includes at least two parallel first input branches 121. By controlling the different on / off states of the at least two parallel first input branches 121, the flow rate of the first infusion line 120 can be controlled, thereby achieving control of the first liquid infusion flow rate. The second infusion line 180 includes at least two parallel second input branches. By controlling the different on / off states of the at least two parallel second input branches, the flow rate of the second infusion line 180 can be controlled, thereby achieving control of the second liquid infusion flow rate. In this embodiment, the first infusion line 120 includes only one first input branch 121, and the flow rate of the first input branch 121 is controlled by a regulating valve to achieve control of the first liquid infusion flow rate; and / or, the second infusion line 180 includes only one second input branch, and the flow rate of the second input branch is controlled by a regulating valve to achieve control of the second liquid infusion flow rate.

[0135] Specifically, in this embodiment, the first infusion line 120 includes a first input branch 121 connecting the first metering tank 110 and the first liquid supply device 20. The first valve assembly 142 includes a first switching valve 1422 for controlling the on / off state of the first input branch 121 and a first flow regulating valve 1427 for regulating the flow rate of the first liquid on the first input branch 121. In practical applications, the on / off state of the first input branch 121 can be controlled by switching the first switching valve 1422, and the flow rate of the liquid on the first input branch 121 can be regulated by regulating the flow rate of the first liquid on the first input branch 121. Of course, in practical applications, as an alternative implementation, the first switching valve 1422 and the first flow regulating valve 1427 can also be replaced by a first switching regulating valve. The first switching regulating valve is used to control the on / off state of the first input branch 121 and regulate the flow rate of the first liquid on the first input branch 121. The first switching regulating valve has both switching and regulating control functions.

[0136] In one embodiment, the second infusion line 180 includes a second input branch connecting the first metering tank 110 and the second liquid supply device 30; the second valve assembly 191 includes a second on / off valve 1911 for controlling the on / off state of the second input branch and a second flow regulating valve for adjusting the flow rate of the second liquid on the second input branch, or the second valve assembly 191 includes a second on / off regulating valve for controlling the on / off state of the second input branch and adjusting the flow rate of the second liquid on the second input branch. The setting principle of the second infusion line 180 and the second liquid flow control assembly 190 is the same as that of the first infusion line 120 and the first liquid flow control assembly 140, and will not be described in detail here.

[0137] Apart from the differences mentioned above, the reagent preparation device 10 and other parts of the sample analysis system provided in this embodiment can be optimized according to any one of embodiments one to five, and will not be described in detail here.

[0138] Example 7:

[0139] Reference Figure 1 , Figure 4 and Figure 9 As shown, the reagent preparation device 10 and sample analysis system provided in this embodiment differ from those in embodiments two to six mainly in the different control methods of the liquid flow rate on the first infusion line 120 and / or the second infusion line 180. Specifically, in embodiments two to six, the first liquid flow control component 140 controls the flow rate of the first liquid by adjusting the flow rate of the first liquid on the first infusion line 120; and the second liquid flow control component 190 controls the flow rate of the second liquid by adjusting the flow rate of the second liquid on the second infusion line 180. In this embodiment, the first liquid flow control component 140 controls the flow rate of the first liquid by adjusting the pressure of the first liquid on the first infusion line 120; and / or, the second liquid flow control component 190 controls the flow rate of the second liquid by adjusting the pressure of the second liquid on the second infusion line 180.

[0140] In one embodiment of this invention, the first power unit 141 includes at least two first drive units 1411 connected in parallel to provide driving force for the first liquid to be input into the first metering tank 110 from the first infusion line 120, and a second drive unit 1412 for driving the first liquid to be discharged from the first metering tank 110 and transported from the first drain line 130 to the first mixing container 300. The first valve assembly 142 includes a second infusion control valve group, which is disposed between the first drive unit 1411 and the first metering tank 110 to control the on / off state of each of the first drive units 1411 and the first metering tank 110. When the first driving component 1411 is a pneumatic driving component (such as a negative pressure device) connected to the first metering tank 110, the second infusion control valve group is an air valve located between the first driving component 1411 and the metering container; when the first driving component 1411 is a liquid pump connected to the first infusion line 120, the second infusion control valve group is a liquid valve located between the first driving component 1411 and the first metering tank 110. In a preferred embodiment, the second infusion control valve group includes a second reversing air valve 1428. By controlling the second infusion control valve group, different first driving components 1411 can be connected or disconnected from the first metering tank 110, thereby controlling the flow pressure of the first liquid. Of course, in specific applications, the arrangement of the first power component 141 and the first valve assembly 142 is not limited to this. For example, as an alternative implementation, when the first drive component 1411 is a liquid pump connected to the first infusion line 120, the first valve assembly 142 can also be a third infusion control valve group (not shown). The third infusion control valve group is located between the first drive component 1411 and the first liquid supply device 20 to control the on / off state between each of the first drive components 1411 and the first liquid supply device 20. Alternatively, as another alternative implementation, a third drive component with adjustable output pressure can be used instead of at least two parallel first drive components 1411 to provide driving force for the first liquid to be input from the first infusion line 120 into the first metering tank 110. In this case, the first valve assembly 142 includes a second switch control valve, which is used to control the on / off state between the second drive component 1412 and the first metering tank 110, or the second switch control valve is used to control the on / off state between the second drive component 1412 and the first liquid supply device 20.

[0141] In a preferred embodiment of this invention, the first driving component 1411 is a negative pressure device capable of generating negative pressure. The first power component 141 includes two first driving components 1411, which are respectively a first negative pressure device and a second negative pressure device. The pressure of the first negative pressure device is less than the pressure of the second negative pressure device. The second infusion control valve group is a second reversing air valve 1428, which is a two-position three-way air valve. The three ports of the second reversing air valve 1428 are respectively connected to the first negative pressure device, the second negative pressure device, and the first reversing air valve 1421. In standby mode, the second negative pressure device and the first metering tank 110 are in a normally connected state, that is, the first reversing air valve 1421 is in a state of connecting the first metering tank 110 and the second reversing air valve 1428, and the second reversing air valve 1428 is in a state of connecting the first reversing air valve 1421 and the second negative pressure device. When the first infusion line 120 starts to deliver the first liquid to the metered tank, the higher negative pressure of the second negative pressure device can drive the first infusion line 120 to quickly feed liquid into the first metering tank 110. When the liquid level in the first metering tank 110 reaches the first liquid level or the infusion time reaches the first preset time, the second reversing air valve 1428 switches to a state of connecting the first reversing air valve 1421 and the first negative pressure device. The lower negative pressure of the first negative pressure device can drive the first infusion line 120 to slowly feed liquid into the first metering tank 110, thereby realizing the regulation of the liquid feeding speed. Of course, in specific applications, the second infusion control valve group is not limited to using the second reversing air valve 1428. For example, as an alternative implementation, the second infusion control valve group can also be two switching air valves, one of which is connected between the first negative pressure device and the first reversing air valve 1421, and the other is connected between the second negative pressure device and the first reversing air valve 1421.

[0142] The principle of speed regulation for the second liquid is the same as that for the first liquid, and will not be elaborated here.

[0143] Apart from the differences mentioned above, the reagent preparation device 10 and sample analysis system provided in this embodiment can be optimized according to any one of embodiments one to six, which will not be described in detail here.

[0144] Example 8:

[0145] Reference Figure 1 , Figure 4 and Figure 10 As shown, the reagent preparation device 10 and sample analysis system provided in this embodiment differ from those in Embodiment 1 mainly in that this embodiment adds a detection component to assist in controlling each preparation process, so as to end the previous process in advance and enter the next process, thereby improving the preparation efficiency of the first reagent.

[0146] In one embodiment of this invention, the reagent preparation apparatus 10 further includes a first emptying detection component 400, which is used to detect whether the first liquid in the first metering tank 110 has been emptied. The controller is also configured to: when the first drain pipe 130 is in a draining state, and it is determined from the information fed back by the first emptying detection component 400 that the first liquid in the first metering tank 110 has been emptied, then control the first drain pipe 130 to stop the draining process. In this embodiment, by setting the first emptying detection component 400 in the first drain pipe 130, the first drain pipe 130 can be controlled to stop the draining process in a timely manner after the first liquid in the first metering tank 110 has been emptied, so as to end the draining process of the first metering tank 110 in advance and enter the mixing process of the first mixing container 300.

[0147] In one implementation, the first emptying detection component 400 is an optocoupler detector installed on the first drain pipe 130. The controller can determine whether liquid is passing through the first drain pipe 130 based on the feedback signal from the optocoupler detector, thereby determining whether the liquid in the first metering tank 110 has been emptied. Of course, in specific applications, the arrangement of the first emptying detection component 400 is not limited to this. For example, the first emptying detection component 400 can also be a pressure sensor installed on the first drain pipe 130; or a flow sensor installed on the first drain pipe 130; or an optocoupler detector, electrode assembly, float sensor, capacitive sensor, or ultrasonic detector installed on the first metering tank 110, etc.

[0148] In one implementation, the first drain valve 1423 is located between the first venting detection component 400 and the first mixing container 300. Draining stops when the first metering tank 110 drains to the first venting detection component 400, without needing to empty the liquid in the first drain pipe 130 and the first drain valve 1423. The liquid volume between the first venting detection component 400 and the second liquid level detection component 160 is a single metered volume.

[0149] In one implementation, the first emptying detection component 400 is located on the bottom outer side of the first metering tank 110, for example, it can be installed at the drain port at the bottom of the first metering tank 110. Of course, in specific applications, as an alternative implementation, the first emptying detection component 400 can also be located on the first drain pipe 130.

[0150] In one embodiment, the reagent preparation apparatus 10 further includes a fourth buffer container 600, a second drain pipe, and a second emptying detection component. The second drain pipe is connected between the first mixing container 300 and the fourth buffer container 600 to transport the first reagent in the first mixing container 300 to the fourth buffer container 600. The second emptying detection component is used to detect whether the liquid in the first mixing container 300 has been drained. The controller is also configured to: when the second drain pipe is in a draining state, and it is determined from the information fed back by the second emptying detection component that the liquid in the first mixing container 300 has been drained, then control the second drain pipe to stop the draining process. In this embodiment, by setting a second emptying detection component in the second drain pipe, the drain pipe can be controlled to stop the draining process in a timely manner after the first reagent in the first mixing container 300 has been drained, thereby facilitating the first mixing container 300 to be ready for the mixing and preparation of the next batch of the first reagent at any time.

[0151] In one implementation, the second evacuation detection component is an optocoupler detector located on the second drain pipe. The controller can determine whether liquid is flowing through the second drain pipe based on the feedback signal from the optocoupler detector, thereby determining whether the liquid in the first mixing container 300 has been emptied. Of course, in specific applications, the arrangement of the second evacuation detection component is not limited to this. For example, the second evacuation detection component can also be a pressure sensor located on the second drain pipe; or a flow sensor located on the second drain pipe; or an optocoupler detector, electrode assembly, float sensor, capacitive sensor, or ultrasonic detector located on the first mixing container 300, etc.

[0152] In one embodiment, the reagent preparation apparatus 10 further includes a liquid supply line 900, a first liquid storage container 500, a third liquid level detection component 1001, and a fourth liquid level detection component 1002. The liquid supply line 900 is used to supply a first liquid to the first liquid storage container 500. A first liquid delivery line 120 is connected between the first liquid storage container 500 and the first metering tank 110. The third liquid level detection component 1001 is used to detect whether the liquid level of the first liquid in the first liquid storage container 500 has reached the third liquid level. The fourth liquid level detection component 1002 is used to detect whether the liquid level of the first liquid in the first liquid storage container 500 has reached the third liquid level. The controller is further configured to: determine whether the liquid level in the first storage container 500 has reached the fourth liquid level, where the third liquid level is lower than the fourth liquid level; and control the supply pipeline 900 to supply the first liquid to the first storage container 500 if the liquid level in the first storage container 500 is lower than the third liquid level based on feedback information from the third liquid level detection component 1001; and control the supply pipeline 900 to stop supplying the first liquid to the first storage container 500 if the liquid level in the first storage container 500 has reached the fourth liquid level based on feedback information from the fourth liquid level detection component 1002. The first storage container 500 is used to store a certain amount of water, so that when preparing the first reagent, the first metering tank 110 can directly measure water from the first storage container, thereby improving the efficiency and continuous stability of the first reagent preparation. The process of supplying water from the liquid supply pipeline 900 to the first liquid storage container 500 can be carried out at any point in the entire preparation process of the first reagent. As long as the third liquid level detection component 1001 in the first liquid storage container 500 detects that the water level in the first liquid storage container 500 is insufficient, it can control the liquid supply pipeline 900 to supply water to the first liquid storage container 500 at any time. After the fourth liquid level detection component 1002 detects that the water level in the first liquid storage container 500 has reached the fourth liquid level, the controller determines that the water level in the first liquid storage container 500 is full, and then controls the liquid supply pipeline 900 to stop supplying water to the first liquid storage container 500.

[0153] In one implementation, when the liquid supply pipeline 900 delivers water to the first liquid storage container 500, the first liquid storage container 500 is placed in an atmospheric pressure environment, and water can be delivered to the first liquid storage container 500 by the water pressure of the liquid supply pipeline 900.

[0154] In one implementation, both the third liquid level detection component 1001 and the fourth liquid level detection component 1002 are float sensors, i.e., in this embodiment, float sensors are used to monitor the liquid level in the first liquid storage container 500. Of course, in specific applications, the third liquid level detection component 1001 and the fourth liquid level detection component 1002 can also use liquid level detection components with other structures, such as electrode groups, capacitive sensors, optocoupler detectors, ultrasonic detectors, etc.

[0155] In one implementation, the controller is further configured to: determine whether to start the preparation process of the first reagent based on feedback information from the third liquid level detection component 1001; when the feedback information from the third liquid level detection component 1001 indicates that the liquid level in the first liquid storage container 500 is lower than the third liquid level, control to pause the start of the preparation process of the first reagent; when the feedback information from the third liquid level detection component 1001 indicates that the liquid level in the first liquid storage container 500 is equal to or higher than the third liquid level, control to start the preparation process of the first reagent. In Example 1, the reagent preparation device 10 prepares the first reagent at a fixed speed. If the water flow rate from the first infusion line 120 to the first quantitative pool 110 is lower than a predetermined value, the preparation speed of the first reagent will not reach the predetermined value (e.g., 18 L / h). At this time, the reagent preparation device 10 will stop and cannot work normally. However, the insufficient water flow rate delivered by the first infusion line 120 may be due to low water pressure, or the reagent preparation device 10 may detect that some water quality does not meet the requirements and discharge it into the waste liquid channel. It may also be that some water temperature exceeds the range and is discharged, resulting in insufficient water flow. If the reagent preparation device 10 stops for these reasons, the continuous stability of the operation of the reagent preparation device 10 will be poor. By adopting this implementation scheme, the problem of reagent preparation device 10 shutting down due to insufficient water flow can be effectively solved. Specifically, in this implementation scheme, before starting the preparation of the first reagent, the third liquid level detection component 1001 of the first liquid storage container 500 is required to detect that the water volume in the first liquid storage container 500 has reached the third liquid level before the preparation of the first reagent can be started. If the third liquid level detection component 1001 detects that the water volume in the first liquid storage container is lower than the third liquid level before starting the preparation, the preparation will be started after the water volume in the first liquid storage container reaches the third liquid level. At this time, the speed of preparing the first reagent will be affected, but it will not cause a shutdown due to insufficient water flow, thus helping to ensure the continuous and stable operation of the reagent preparation device 10.

[0156] As one implementation method, a water flow sensor can also be installed in the liquid supply line 900, which makes it easier to adjust the reagent preparation speed according to the water flow.

[0157] As one implementation method, a conductivity sensor can also be installed in the liquid supply line 900 to detect whether the conductivity of the water transported by the liquid supply line 900 is qualified.

[0158] In one embodiment, the reagent preparation apparatus 10 further includes a suction line 1006 and a second liquid storage container 1007. The suction line 1006 is connected between the second liquid supply device 30 and the second liquid storage container 1007 for delivering a second liquid to the second liquid storage container 1007. The second liquid delivery line 180 is connected between the second liquid storage container 1007 and the first metering pool 110.

[0159] In one embodiment, there may be two or more aspiration tubes 1006 and second liquid supply devices 30. In a preferred embodiment, the reagent preparation device 10 includes a first aspiration tube, a second aspiration tube, and an aspiration control component 1003. The first aspiration tube is used to connect to one reagent stock source, the second aspiration tube is used to connect to another reagent stock source, and the aspiration control component 1003 is used to control the first aspiration tube to draw reagent stock from one reagent stock source and deliver it to the first metering tank 110, and to control the second aspiration tube to draw reagent stock from another reagent stock source and deliver it to the first metering tank 110. In this implementation scheme, the first and second suction tubes are connected to different reagent stock solution sources, respectively. The suction control component 1003 controls the first and second suction tubes to draw reagent stock solution from different reagent stock solution sources and deliver it to the first quantitative cell 110. In practical applications, reagent stock solution is first drawn from one reagent stock solution source using one suction tube to prepare reagents. When the reagent stock solution from that source is insufficient, the suction control component 1003 can switch to another suction tube to draw reagent stock solution from another reagent stock solution source to prepare reagents. This achieves a continuous supply of reagent stock solution to the reagent preparation device 10, ensuring that the sample analysis system can continue to operate for a long time without interruption even when the reagent stock solution from one source is insufficient. This provides users with sufficient time to replace the insufficient reagent stock solution source, effectively achieving the effect of changing reagent stock solution sources during idle periods without interruption, and fully guaranteeing the continuous stability of the sample analysis system operation.

[0160] Specifically, the preparation process of the first reagent includes a liquid filling process of the first storage container 500, a liquid draining process of the first storage container 500, a liquid filling process of the second storage container 1007, a liquid draining process of the second storage container 1007, a liquid metering process of the first metering pool 110, a liquid metering process of the first metering pool 110, a liquid draining process of the first metering pool 110, a mixing process of the first mixing container 300, and a liquid draining process of the first mixing container 300. In Embodiment 1, the time of each process node in the reagent preparation device 10 for preparing the first reagent is fixed, and the preparation speed cannot be dynamically adjusted, which is not conducive to improving the preparation efficiency of the first reagent. In this embodiment, the completion time of each process node is monitored in real time by a detection component to end the process in advance and enter the next process, thereby improving the preparation efficiency of the first reagent. Among them, the liquid filling process of the first storage container 500 can be carried out at any time, mainly controlled by the feedback information of the third liquid level detection component 1001 and the fourth liquid level detection component 1002. To improve preparation efficiency, the liquid filling process of the second liquid storage container 1007 can be carried out simultaneously with the liquid draining process of the first metering tank 110; one of the liquid metering process of the first metering tank 110 and the liquid metering process of the first metering tank 110 can be carried out simultaneously with the mixing process of the first mixing container 300 or the liquid draining process of the first mixing container 300; the liquid draining process of the first metering tank 110 can be carried out simultaneously with the liquid draining process of the first mixing container 300.

[0161] Apart from the differences mentioned above, the reagent preparation device 10 and sample analysis system provided in this embodiment can be optimized according to any one of embodiments one to seven, which will not be described in detail here.

[0162] Example 9:

[0163] Reference Figure 1 and Figure 11 As shown, the reagent preparation device 10 and sample analysis system provided in this embodiment differ from those in Embodiment 1 mainly in the quantity of reagents that the reagent preparation device 10 can prepare. Specifically, in Embodiment 1, the reagent preparation device 10 can prepare one type of reagent; while in this embodiment, the reagent preparation device 10 can prepare two different types of reagents.

[0164] Specifically, in this embodiment, the sample processing system further includes a first sample processing device 40 and a second sample processing device 60. The first sample processing device 40 and the second sample processing device 60 are two sample processing devices using different reagents, wherein the first sample processing device 40 uses a first reagent and the second sample processing device 60 uses a second reagent. A first mixing container 300 is connected to the first sample processing device 40 for supplying the first reagent to the first sample processing device 40. The reagent preparation apparatus 10 further includes a second quantitative system 200 and a second mixing container 1005. The second quantitative system 200 is used to measure a first liquid and a third liquid. The second mixing container 1005 is connected to the second quantitative system 200 to mix the first liquid and the third liquid measured by the second quantitative system 200 to prepare a second reagent. The second mixing container 1005 is also connected to a second sample processing device 60 to supply the second reagent to the second sample processing device 60. The reagent preparation apparatus 10 is configured to simultaneously supply the second reagent to the second sample processing device 60 while supplying the first reagent to the first sample processing device 40, i.e., the time period during which the reagent preparation apparatus 10 supplies the first reagent to the first sample processing device 40 can overlap with the time period during which it supplies the second reagent to the second sample processing device 60. In this embodiment, a single reagent preparation apparatus 10 can prepare two different types of reagents, the first reagent and the second reagent, and supply them to different sample processing devices, effectively solving the problem that different sample processing devices require multiple reagent preparation apparatuses 10 to prepare reagents, resulting in a large footprint and high cost for the sample processing system.

[0165] In this embodiment, there is one first liquid storage container 500, and the first metering system 100 and the second metering system 200 are respectively connected to the first liquid storage container 500. There is one second liquid storage container 1007, which is connected between the first reagent stock source and the first metering system 100. The reagent preparation device 10 also includes a third liquid storage container 1004, which is connected between the second reagent stock source and the second metering system 200. In this embodiment, the first reagent preparation channel and the second reagent preparation channel share a first water storage container for water supply to prepare reagents, which helps to reduce the volume and cost of the reagent preparation device 10.

[0166] In one implementation, the sample processing system further includes a third sample processing device 70. The first mixing container 300 is connected to both the first sample processing device 40 and the third sample processing device 70 to supply a first reagent to both devices. The reagent preparation device 10 is configured to simultaneously supply the first reagent to the third sample processing device 70 while supplying the first reagent to the first sample processing device 40; that is, the time period during which the reagent preparation device 10 supplies the first reagent to the first sample processing device 40 can overlap with the time period during which it supplies the first reagent to the third sample processing device 70. In this embodiment, a single reagent preparation device 10 can simultaneously supply the same reagent to different sample processing devices. This effectively solves the problem of large footprint and high cost in sample processing systems caused by the need for multiple reagent preparation devices 10 to prepare reagents for different sample processing devices. Of course, in specific applications, the second reagent prepared by the reagent preparation device 10 can also be supplied to two or more sample processing devices simultaneously.

[0167] Apart from the differences mentioned above, the reagent preparation device 10 and sample analysis system provided in this embodiment can be optimized according to any one of embodiments one to eight, which will not be described in detail here.

[0168] Example 10:

[0169] Reference Figure 1 and Figure 12 As shown, the reagent preparation device 10 and sample analysis system provided in this embodiment differ from those in embodiment nine mainly in that: in this embodiment, two or more buffer containers are set downstream of a mixing container to store the same reagent respectively.

[0170] Specifically, the sample processing system further includes a first buffer container 50 and a second buffer container 80; the first buffer container 50 is connected between the first mixing container 300 and a sample processing device for supplying a first reagent to the sample processing device; the second buffer container 80 is connected between the first mixing container 300 and another sample processing device for supplying the first reagent to the other sample processing device. In this embodiment, the first buffer container 50 is specifically connected between the first mixing container 300 and the first sample processing device 40, and the second buffer container 80 is specifically connected between the first mixing container 300 and the third sample processing device 70. When the sample processing system includes two or more sample processing devices, there is a problem that the reagent preparation device 10 is far from some of the sample processing devices. Similarly, if only a buffer container for storing reagents is placed after the first mixing container 300 of the reagent preparation device 10, the buffer container will also be far from some of the sample processing devices. This results in greater flow resistance when delivering reagents to sample processing devices far from the reagent preparation device 10 and the buffer container, thus affecting the reagent delivery time and requiring an extended delivery time. This embodiment uses two or more buffer containers to deliver the same reagent to different sample processing devices, effectively solving the problem of long reagent aspiration times for some sample processing devices when multiple sample processing devices share a single reagent preparation device 10. Of course, in specific applications, when the reagent preparation device 10 delivers a second reagent to multiple sample processing devices, multiple buffer containers can also be placed between the corresponding sample processing device and the second mixing container 1005.

[0171] In one implementation, the first buffer container 50 is connected to two or more sample processing devices simultaneously, and / or the second buffer container 80 is connected to two or more sample processing devices simultaneously; that is, one buffer container can also be connected to two or more sample processing devices simultaneously. In specific applications, when two sample processing devices using the same reagent are close to each other, the same reagent can also be delivered to both sample processing devices simultaneously through one buffer container; that is, two sample processing devices that are close to each other and use the same reagent can be connected to the same buffer container.

[0172] In one implementation, the sample processing system may further include a third buffer container (not shown); the first buffer container 50 and the third buffer container are connected in parallel between the first mixing container 300 and a sample processing device, respectively for supplying the first reagent to the same sample processing device. For example, the first buffer container 50 and the third buffer container are connected in parallel between the first mixing container 300 and the first sample processing device 40.

[0173] Apart from the differences mentioned above, the other parts of the reagent preparation device 10 and sample processing system provided in this embodiment can be optimized by referring to any one of embodiments one to nine, and will not be described in detail here.

[0174] The above are merely preferred embodiments of the present invention and do not limit the scope of the patent. Any equivalent structural transformations made using the contents of the specification and drawings of the present invention under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the scope of patent protection of the present invention.

Claims

1. A reagent preparation apparatus, characterized in that: include: A first metering system, the first metering system being used to measure a first liquid and a second liquid; A first mixing container, connected to the first metering system, is used to mix the first liquid and the second liquid measured by the first metering system to prepare a first reagent; The controller is used to control the first metering system to measure the first liquid and to control the first metering system to deliver the measured first liquid to the first mixing container, and to control the first metering system to measure the second liquid and to control the first metering system to deliver the measured second liquid to the first mixing container; The first quantitative system includes: A first metering chamber is used to measure the first liquid and the second liquid; The first infusion line is connected to the first metering tank for delivering the first liquid to be measured into the first metering tank. The second infusion line is connected to the first metering pool for delivering the second liquid to be measured into the first metering pool. The first drain line is connected between the first metering tank and the first mixing container to drain the first liquid measured by the first metering tank into the first mixing container, and to drain the second liquid measured by the first metering tank into the first mixing container. First liquid flow control assembly; The first metering system further includes a first liquid level detection component and a second liquid level detection component. The first liquid level detection component is used to detect whether the liquid level in the first metering tank has reached a first liquid level, and the second liquid level detection component is used to detect whether the liquid level in the first metering tank has reached a second liquid level. The controller is configured to: during the process of the first infusion pipeline delivering the first liquid to the first metering tank, when it is determined, based on the feedback information from the first liquid level detection component, that the liquid level in the first metering tank is lower than the first liquid level, control the first liquid flow control component to regulate the first liquid to be delivered into the first metering tank at a first flow rate; when it is determined, based on the feedback information from the first liquid level detection component and the second liquid level detection component, that the liquid level in the first metering tank is equal to or higher than the first liquid level and lower than the second liquid level, control the first liquid flow control component to regulate the first liquid to be delivered into the first metering tank at a second flow rate; when it is determined, based on the feedback information from the second liquid level detection component, that the liquid level in the first metering tank is equal to the second liquid level, control the first liquid flow control component to operate to control the first infusion pipeline to stop delivering the first liquid to the first metering tank; wherein, the first liquid level is lower than the second liquid level, and the first flow rate is greater than the second flow rate; or, The first metering system further includes a first timing component and a second liquid level detection component. The first timing component is used to calculate the time for the first infusion line to deliver the first liquid into the first metering pool, and the second liquid level detection component is used to detect whether the liquid level in the first metering pool has reached a second liquid level. The controller is configured to: during the process of the first infusion line delivering the first liquid into the first metering pool, when it is determined, based on feedback information from the first timing component, that the time for the first infusion line to deliver the first liquid into the first metering pool is less than a first preset time, control the first liquid flow control component to regulate the first liquid to be delivered into the first metering pool at a first flow rate; when Based on the feedback information from the first timing component and the second liquid level detection component, when it is determined that the time for the first infusion pipeline to deliver the first liquid into the first metering pool is greater than or equal to the first preset time, and the liquid level in the first metering pool is lower than the second liquid level, the first liquid flow control component is controlled to regulate the first liquid to be delivered into the first metering pool at a second flow rate; when it is determined, based on the feedback information from the second liquid level detection component, that the liquid level in the first metering pool is equal to the second liquid level, the first liquid flow control component is controlled to operate to control the first infusion pipeline to stop delivering the first liquid into the first metering pool; wherein, the first flow rate is greater than the second flow rate.

2. The reagent preparation apparatus as described in claim 1, characterized in that: The first metering cell is used to measure the required amount of the second liquid in one preparation of the first reagent, and is also used to measure the required amount of the first liquid in one preparation of the first reagent in at least two separate measurements.

3. The reagent preparation apparatus as described in claim 2, characterized in that: The controller is configured to: first, control the first quantitative system to measure the required amount of the second liquid in one preparation of the first reagent and deliver it to the first mixing container; then, control the first quantitative system to measure the required amount of the first liquid in one preparation of the first reagent and deliver it to the first mixing container in at least two separate measurements; or, The controller is configured to: first, control the first quantitative system to measure the first liquid and deliver it to the first mixing container *a* times; then, control the first quantitative system to measure the required amount of the second liquid in one preparation of the first reagent and deliver it to the first mixing container; then, control the first quantitative system to measure the first liquid and deliver it to the first mixing container *b* times, wherein *a* and *b* are both integers greater than 1, and the sum of the volumes of the first liquid measured a times and the volumes of the first liquid measured b times equals the required amount of the first liquid in the preparation of the first reagent; or... The controller is configured to: first control the first quantitative system to measure the required amount of the first liquid in one preparation of the first reagent at least twice and deliver it to the first mixing container; then control the first quantitative system to measure the required amount of the second liquid in one preparation of the first reagent and deliver it to the first mixing container in one go.

4. The reagent preparation apparatus as described in claim 1, characterized in that: The first metering cell is used to measure the required amount of the first liquid in a single preparation of the first reagent, and is also used to measure the required amount of the second liquid in a single preparation of the first reagent.

5. The reagent preparation apparatus as described in claim 1, characterized in that: The first liquid flow control component is also configured to perform the following actions under the control of the controller: control the first drain pipe to discharge the first liquid in the first metering tank into the first mixing container, and control the first drain pipe to stop discharging the first liquid into the first mixing container.

6. The reagent preparation apparatus as described in claim 5, characterized in that: The second liquid level is level with the liquid level in the first metering tank corresponding to the required metering of the second liquid in one preparation of the first reagent; or... The second liquid level is higher than the liquid level corresponding to the required amount of the second liquid in the first metering tank during the preparation of the first reagent. The first metering system also includes an overflow pipe. The first metering tank is provided with an overflow port. The overflow port is flush with the liquid level corresponding to the required amount of the second liquid in the first metering tank during the preparation of the first reagent. One end of the overflow pipe is connected to the overflow port to discharge the liquid in the first metering tank located above the overflow port.

7. The reagent preparation apparatus as described in claim 5, characterized in that: The first infusion line includes at least two first input branches connected in parallel between the first metering tank and the first supply device. The first liquid flow control assembly includes a first power component and a first valve assembly. The first power component is used to drive the first liquid into the first metering tank from the first infusion line and to drive the first liquid out of the first metering tank and transport it to the first mixing container from the first drain line. The first valve assembly includes a first infusion control valve group for controlling the on / off state of each of the first input branches between the first metering tank and the first supply device; or... The first infusion line includes a first input branch connecting the first metering tank and the first infusion device; The first liquid flow control assembly includes a first power component and a first valve assembly. The first power component is used to drive the first liquid from the first infusion line into the first metering tank and to drive the first liquid out of the first metering tank and transport it from the first drainage line to the first mixing container. The first valve assembly includes a first switch control valve for controlling the on / off state of the first input branch and a first flow regulating valve for adjusting the flow rate of the first liquid on the first input branch; alternatively, the first valve assembly includes a first switch regulating valve for controlling the on / off state of the first input branch and adjusting the flow rate of the first liquid on the first input branch. The first liquid flow control assembly includes a first power component and a first valve assembly. The first power component includes at least two first drive components arranged in parallel to provide driving force for the first liquid to be input into the first metering tank from the first infusion line, and a second drive component to drive the first liquid to be discharged from the first metering tank and transported to the first mixing container from the first drainage line. The first valve assembly includes a second infusion regulating valve group for controlling the on / off state between each of the first drive components and the first metering tank; or the first valve assembly includes a third infusion regulating valve group for controlling the on / off state between each of the first drive components and the first liquid supply device; or... The first liquid flow control assembly includes a first power component and a first valve assembly. The first power component includes a second drive component for driving the first liquid to be discharged from the first metering tank and transported to the first mixing container through the first drain line, and a third drive component whose output pressure is adjustable and is used to provide driving force for the first liquid to be input into the first metering tank through the first infusion line. The first valve assembly includes a second switch control valve for controlling the on / off state between the second drive component and the first metering tank, or for controlling the on / off state between the second drive component and the first liquid supply device.

8. The reagent preparation apparatus as described in claim 1, characterized in that: The first metering system further includes a second liquid flow control component, which, under the control of the controller, performs the following actions: controlling the second infusion line to deliver the second liquid to the first metering tank and adjusting the flow rate of the second liquid delivered from the second infusion line into the first metering tank; controlling the second infusion line to stop delivering the second liquid to the first metering tank; controlling the first drainage line to discharge the second liquid in the first metering tank into the first mixing container; and controlling the first drainage line to stop discharging the second liquid into the first mixing container.

9. The reagent preparation apparatus as described in claim 8, characterized in that: The controller is configured to: during the process of the first metering system measuring the second liquid, control the second liquid flow control component to regulate the second infusion pipeline to deliver the second liquid into the first metering pool at at least two different flow rates, and control the second liquid flow control component to regulate the flow rate of the second liquid delivered into the first metering pool to change sequentially from large to small.

10. The reagent preparation apparatus according to any one of claims 1 to 8, characterized in that: The second liquid is the first reagent stock solution, and the first liquid is a diluent used to dilute the first reagent stock solution.

11. The reagent preparation apparatus according to any one of claims 1 to 8, characterized in that: The first metering pool includes a pool body and a pool nozzle. The pool nozzle is located above the pool body and communicates with the pool body, and the inner diameter of the pool body is larger than the inner diameter of the pool nozzle.

12. The reagent preparation apparatus as described in claim 1, characterized in that: The reagent preparation device further includes a second liquid level detection component, which is used to detect whether the liquid in the first metering pool has reached a second liquid level. The liquid includes a second liquid. The controller is further configured to: when it is determined, based on the feedback information from the second liquid level detection component, that the liquid level in the first metering pool has reached the second liquid level, control the first infusion line or the second infusion line to stop supplying liquid to the first metering pool, and control the first drainage line to transport the liquid in the first metering pool to the first mixing container.

13. The reagent preparation apparatus according to any one of claims 1 to 8, characterized in that: The reagent preparation device further includes a first emptying detection component, which is used to detect whether the liquid in the first quantitative pool has been emptied; the controller is also configured to: when the first draining pipeline is in the draining state, and it is determined from the information fed back by the first emptying detection component that the liquid in the first quantitative pool has been emptied, then control the first draining pipeline to stop the draining process.

14. The reagent preparation apparatus according to any one of claims 1 to 8, characterized in that: The reagent preparation device further includes a fourth buffer container, a second drain pipe, and a second emptying detection component. The second drain pipe is connected between the first mixing container and the fourth buffer container to transport the first reagent in the first mixing container to the fourth buffer container. The second emptying detection component is used to detect whether the liquid in the first mixing container has been drained. The controller is further configured to: when the second drain pipe is in the draining state, and it is determined from the information fed back by the second emptying detection component that the liquid in the first mixing container has been drained, control the second drain pipe to stop the draining process.

15. The reagent preparation apparatus according to any one of claims 1 to 8, characterized in that: The reagent preparation device further includes a liquid supply line, a first liquid storage container, a third liquid level detection component, and a fourth liquid level detection component. The liquid supply line is used to deliver a first liquid to the first liquid storage container. The first liquid supply line is connected between the first liquid storage container and the first metering pool. The third liquid level detection component is used to detect whether the liquid level of the first liquid in the first liquid storage container has reached a third liquid level. The fourth liquid level detection component is used to detect whether the liquid level of the first liquid in the first liquid storage container has reached a fourth liquid level. The third liquid level is lower than the fourth liquid level. The controller is further configured to: when it is determined, based on the feedback information from the third liquid level detection component, that the liquid level in the first liquid storage container is lower than the third liquid level, determine that the first liquid in the first liquid storage container is insufficient and control the liquid supply line to deliver the first liquid to the first liquid storage container; when it is determined, based on the feedback information from the fourth liquid level detection component, that the liquid level in the first liquid storage container has reached the fourth liquid level, control the liquid supply line to stop delivering the first liquid to the first liquid storage container.

16. The reagent preparation apparatus as described in claim 15, characterized in that: The controller is further configured to: determine whether to start the preparation process of the first reagent based on the feedback information from the third liquid level detection component; when the feedback information from the third liquid level detection component indicates that the liquid level in the first liquid storage container is lower than the third liquid level, control to pause the start of the preparation process of the first reagent; when the feedback information from the third liquid level detection component indicates that the liquid level in the first liquid storage container is equal to or higher than the third liquid level, control to start the preparation process of the first reagent.

17. A sample analysis system, characterized in that: It includes a reagent preparation device and at least one sample processing device, wherein the reagent preparation device is used to deliver a first reagent prepared by mixing in a first mixing container of the reagent preparation device to the sample processing device; The reagent preparation apparatus includes: A first metering system, the first metering system being used to measure a first liquid and a second liquid; The first mixing container is connected to the first metering system for mixing the first liquid and the second liquid measured by the first metering system to prepare a first reagent; The controller is used to control the first metering system to measure the first liquid and deliver the measured first liquid to the first mixing container, and to control the first metering system to measure the second liquid and deliver the measured second liquid to the first mixing container; The first quantitative system includes: A first metering chamber is used to measure the first liquid and the second liquid; The first infusion line is connected to the first metering tank for delivering the first liquid to be measured into the first metering tank. The second infusion line is connected to the first metering pool for delivering the second liquid to be measured into the first metering pool. The first drain line is connected between the first metering tank and the first mixing container to drain the first liquid measured by the first metering tank into the first mixing container, and to drain the second liquid measured by the first metering tank into the first mixing container. First liquid flow control assembly; The first metering system further includes a first liquid level detection component and a second liquid level detection component. The first liquid level detection component is used to detect whether the liquid level in the first metering tank has reached a first liquid level, and the second liquid level detection component is used to detect whether the liquid level in the first metering tank has reached a second liquid level. The controller is configured to: during the process of the first infusion pipeline delivering the first liquid to the first metering tank, when it is determined, based on the feedback information from the first liquid level detection component, that the liquid level in the first metering tank is lower than the first liquid level, control the first liquid flow control component to regulate the first liquid to be delivered into the first metering tank at a first flow rate; when it is determined, based on the feedback information from the first liquid level detection component and the second liquid level detection component, that the liquid level in the first metering tank is equal to or higher than the first liquid level and lower than the second liquid level, control the first liquid flow control component to regulate the first liquid to be delivered into the first metering tank at a second flow rate; when it is determined, based on the feedback information from the second liquid level detection component, that the liquid level in the first metering tank is equal to the second liquid level, control the first liquid flow control component to operate to control the first infusion pipeline to stop delivering the first liquid to the first metering tank; wherein, the first liquid level is lower than the second liquid level, and the first flow rate is greater than the second flow rate; or, The first metering system further includes a first timing component and a second liquid level detection component. The first timing component is used to calculate the time for the first infusion line to deliver the first liquid into the first metering pool, and the second liquid level detection component is used to detect whether the liquid level in the first metering pool has reached a second liquid level. The controller is configured to: during the process of the first infusion line delivering the first liquid into the first metering pool, when it is determined, based on feedback information from the first timing component, that the time for the first infusion line to deliver the first liquid into the first metering pool is less than a first preset time, control the first liquid flow control component to regulate the first liquid to be delivered into the first metering pool at a first flow rate; when Based on the feedback information from the first timing component and the second liquid level detection component, when it is determined that the time for the first infusion pipeline to deliver the first liquid into the first metering pool is greater than or equal to the first preset time, and the liquid level in the first metering pool is lower than the second liquid level, the first liquid flow control component is controlled to regulate the first liquid to be delivered into the first metering pool at a second flow rate; when it is determined, based on the feedback information from the second liquid level detection component, that the liquid level in the first metering pool is equal to the second liquid level, the first liquid flow control component is controlled to operate to control the first infusion pipeline to stop delivering the first liquid into the first metering pool; wherein, the first flow rate is greater than the second flow rate.

18. The sample analysis system as described in claim 17, characterized in that: The first metering cell is used to measure the required amount of the second liquid in a single preparation of the first reagent, and is also used to measure the required amount of the first liquid in a single preparation of the first reagent in at least two separate measurements; or, The first metering cell is used to measure the required amount of the first liquid in a single preparation of the first reagent, and is also used to measure the required amount of the second liquid in a single preparation of the first reagent.

19. The sample analysis system as described in claim 18, characterized in that: The first metering system further includes a second liquid flow control component. The first liquid flow control component, under the control of the controller, performs the following actions: controlling the first drain line to discharge the first liquid from the first metering tank into the first mixing container, and controlling the first drain line to stop discharging the first liquid into the first mixing container. The second liquid flow control component, under the control of the controller, performs the following actions: controlling the second infusion line to deliver the second liquid to the first metering tank and adjusting the flow rate of the second liquid delivered from the second infusion line into the first metering tank, controlling the second infusion line to stop delivering the second liquid to the first metering tank, controlling the first drain line to discharge the second liquid from the first metering tank into the first mixing container, and controlling the first drain line to stop discharging the second liquid into the first mixing container.

20. The sample analysis system as described in claim 19, characterized in that: The controller is configured to: during the process of the first quantitative system measuring the second liquid, control the second liquid flow control component to regulate the second infusion pipeline to first deliver the second liquid into the first quantitative pool at a third flow rate, and then deliver the second liquid into the first quantitative pool at a fourth flow rate, wherein the third flow rate is greater than the fourth flow rate.

21. The sample analysis system according to any one of claims 17 to 20, characterized in that: The at least one sample processing device includes a first sample processing device and a second sample processing device; The first mixing container is connected to the first sample processing device for supplying the first reagent to the first sample processing device; The reagent preparation apparatus further includes: A second quantitative system is used to measure the first liquid and the third liquid; A second mixing container, connected to the second metering system, is used to mix the first liquid and the third liquid measured by the second metering system to prepare a second reagent; The second mixing container is also connected to the second sample processing device for supplying the second reagent to the second sample processing device; The reagent preparation device is configured to simultaneously supply the second reagent to the second sample processing device while supplying the first reagent to the first sample processing device.

22. The sample analysis system according to any one of claims 17 to 20, characterized in that: The at least one sample processing device includes a first sample processing device and a third sample processing device; the first mixing container is connected to both the first sample processing device and the third sample processing device to supply the first reagent to the first sample processing device and the third sample processing device, respectively. The reagent preparation device is configured to simultaneously supply the first reagent to the third sample processing device while supplying the first reagent to the first sample processing device.

23. The sample analysis system according to any one of claims 17 to 20, characterized in that: The sample analysis system further includes a first buffer container and a second buffer container; the first buffer container is connected between the first mixing container and one of the sample processing devices for supplying the first reagent to one of the sample processing devices; the second buffer container is connected between the first mixing container and another of the sample processing devices for supplying the first reagent to the other sample processing device; and / or, The sample analysis system further includes a first buffer container and a third buffer container; the first buffer container and the third buffer container are connected in parallel between the first mixing container and one of the sample processing devices, so as to supply the first reagent to the same sample processing device respectively.

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