A kind of encapsulated supramolecular oil-controlling and antibacterial composition, preparation method and application thereof

Abstract

The present invention discloses an encapsulated supramolecular oil control and antibacterial composition, a preparation method and its application. The encapsulated supramolecular oil control and antibacterial composition is composed of an organic acid, a basic amino acid and a cyclodextrin, wherein the organic acid is selected from one or more of salicylic acid, capryloyl glycine, azelaic acid and succinic acid, wherein the organic acid and the basic amino acid are connected by hydrogen bonds to form a supramolecular organic acid, and the composition contains a cyclodextrin inclusion complex formed by encapsulating the organic acid supramolecular. The oil control and antibacterial composition of the present invention encapsulates the organic acid supramolecular by cyclodextrin molecules, has good water solubility, low irritation, easy compatibility, high bioavailability, and the active components are not easy to precipitate. The combination of organic acids can also produce a synergistic effect, and the oil control and antibacterial effect is better.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and relates to a cosmetic intermediate component with oil-controlling and antibacterial effects, and specifically relates to an encapsulated supramolecular oil-controlling and antibacterial composition, and a preparation method and application thereof. Background Art

[0002] Various active substances or functional additives are often added to cosmetics to achieve better effects. For example, anti-dandruff agents are often added to shampoo products. The formation of dandruff is related to seborrheic dermatitis of the scalp, which is caused by the overgrowth of a skin fungus, Malassezia furfur. Literature shows that Malassezia and scalp lipids are necessary factors for the production of dandruff. Oily scalp and Malassezia are the root causes of scalp problems, so adding oil-controlling and antibacterial components to shampoo products can achieve better anti-dandruff effects.

[0003] Capryloylglycine, azelaic acid, succinic acid, salicylic acid, etc. are common additives in cosmetics, which have the functions of regulating skin, killing bacteria and inhibiting bacteria, etc. For example, succinic acid is a good surfactant and also has antibacterial effects. It has inhibitory effects on Staphylococcus aureus and Catarrhalis, etc. It can be used as a pH regulator, surfactant, antioxidant, astringent and antibacterial agent in cosmetics.

[0004] Capryloyl glycine is the main component of dermal structural protein, and one of its important functions is to balance the pH value of the skin. The pH of the skin is around 5.5 because it contains various weak acids, proteins and fats. When different components react with the fat proteins in the skin, these proteins will undergo a decarboxylation reaction, thereby changing the pH value of the skin. A pH value that is too high or too low is not good, especially for acne skin. Many studies have shown that the pH value of acne skin is high. The presence of capryloyl glycine can provide free carboxyl groups to maintain the balance of the skin's pH value. Capryloyl glycine can also be used as a conditioner, foaming agent, etc. in cosmetics. It has good affinity with the skin and can also efficiently deliver other ingredients, so it can improve the use effect of other functional products. At the same time, capryloyl glycine also has certain effects on effectively inhibiting the activation of elastase, preventing the decomposition of elastin, reducing skin wrinkles, and regulating the self-repair of the skin. In addition, capryloyl glycine has a good antibacterial effect, and has a strong inhibitory effect on Staphylococcus aureus and Propionibacterium acnes. It can also resist the excessive secretion of sebum and has a more obvious effect on the prevention and treatment of acne. However, capryloyl glycine is a fat-soluble substance. It needs a solubilizer or surfactant to be dissolved and dispersed in an aqueous system, which limits its application in some aqueous systems.

[0005] Azelaic acid (also known as azelaic acid) has antibacterial properties and can be used as a food preservative. It can directly inhibit and kill bacteria on the skin surface and in hair follicles, eliminating pathogens. Azelaic acid is also a recognized compound that regulates skin oil secretion. It is used in hair care products in combination with vitamin B6. It is suitable for the treatment of male hormonal alopecia in men with strong endocrine secretions, and stimulates hair growth at the same time. However, azelaic acid is basically insoluble in water and is difficult to be directly applied to cosmetics. Its disodium or dipotassium salt is often used in cosmetic formulas, but it affects its physiological activity or functionality.

[0006] Salicylic acid has the effects of keratin regulation, pore dredging, pore shrinking, oil control, and anti-inflammatory, and is widely used in cosmetics. Salicylic acid has a solubility of 2g / L in water at 20°C, and is almost insoluble in water. Direct addition to skin care product formulas is prone to crystallization and precipitation, reducing its bioavailability. Since salicylic acid itself has poor water solubility and emits a strong irritating odor, it is often made into supramolecular preparations in practical applications to enhance water solubility. Methods for solving the problem of salicylic acid application in cosmetics also include chemical modification, liposomalization, microencapsulation, etc. Salicylic acid derivatives include betaine salicylate, capryloyl salicylic acid, tridecyl salicylate, etc. These substances obtained by chemical modification have improved their solubility or irritation problems to a certain extent, but have not fundamentally solved the problem.

[0007] In order to ensure the stability of the product and avoid the crystallization of capryloyl glycine, salicylic acid, etc., a large amount of solvents are often used in practical applications, such as alcohol to dissolve them first, and then a large amount of surfactants are added to help them dissolve in water. However, high levels of alcohol and surfactants in cosmetics can irritate the skin, scalp, etc., and consumers do not like cosmetics containing a large amount of alcohol, which limits their sufficient addition in the formula, resulting in insignificant product effects. Summary of the invention

[0008] The purpose of the present invention is to provide an encapsulated supramolecular oil-control and antibacterial composition and a preparation method thereof in view of the defects and shortcomings of the prior art, which has oil-control and antibacterial effects, good water solubility, low irritation, and good bioavailability. As a cosmetic intermediate component, the solubility, permeability, irritation, and stability are greatly improved, and it is convenient to add and apply.

[0009] Another object of the present invention is to provide a cosmetic intermediate having oil-controlling and antibacterial effects.

[0010] Another object of the present invention is to provide an application of the encapsulated supramolecular oil-controlling and antibacterial composition in cosmetics.

[0011] To achieve the above object, the present invention adopts the following technical solutions:

[0012] A supramolecular oil-control and antibacterial encapsulated composition is composed of an organic acid, a basic amino acid and cyclodextrin, wherein the organic acid is selected from one or more of salicylic acid, capryloylglycine, azelaic acid and succinic acid, wherein the organic acid and the basic amino acid are linked to form a supramolecular organic acid through hydrogen bonds, and the composition contains a cyclodextrin inclusion complex formed by cyclodextrin encapsulating the organic acid supramolecular.

[0013] Inclusion compounds refer to inclusion bodies formed by a molecule of an active substance being embedded in the cavity structure of another molecule of a substance (composition), also known as "molecular capsules". Among them, the inclusion molecule with a cavity structure is called the main molecule, and the embedded molecule is called the guest molecule. The oil-control and antibacterial composition is mainly a cyclodextrin inclusion compound with cyclodextrin as the main molecule, wherein the guest molecule is a supramolecular organic acid composed of organic acids such as capryloylglycine and basic amino acids. The cyclodextrin inclusion compound is composed of a main molecule, cyclodextrin, and a guest molecule, supramolecular organic acid, encapsulated in the main molecule, or it is called an encapsulated supramolecular organic acid. The supramolecular organic acid is embedded in the inner cavity of cyclodextrin through molecular encapsulation to form an oil-control and antibacterial composition in the form of an encapsulated supramolecular organic acid.

[0014] Furthermore, the mass ratio of the organic acid to the basic amino acid is 1:10-10:1, preferably 1:5-5:1, and more preferably 1:3-3:1.

[0015] The mass ratio of supramolecular organic acid to cyclodextrin is 1:20-20:1, preferably 1:10-10:1, and more preferably 1:5-5:1.

[0016] Preferably, in the encapsulated supramolecular oil control and antibacterial composition, the organic acid is selected from salicylic acid and capryloyl glycine, wherein the mass ratio of salicylic acid to capryloyl glycine is 1:10-10:1. The pH value of the encapsulated supramolecular organic acid solution of salicylic acid and capryloyl glycine is in the range of 3-7, preferably in the range of 3.5-6.5, and more preferably in the range of 4.0-6.0.

[0017] In the encapsulated supramolecular oil control and antibacterial composition, the main molecule cyclodextrin is α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin or its derivatives, preferably β-cyclodextrin, γ-cyclodextrin, hydroxyethyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin, dihydroxypropyl-β-cyclodextrin, methyl-β-cyclodextrin, glucose cyclodextrin, maltose cyclodextrin or carboxymethyl cyclodextrin, or a combination of two or more thereof.

[0018] In the encapsulated supramolecular oil control and antibacterial composition, the guest molecule is a supramolecular organic acid composed of an organic acid and a basic amino acid, and the organic acid and the basic amino acid are connected by hydrogen bonds through the carboxyl group of the organic acid and the amino group of the basic amino acid to form a supramolecular organic acid. Wherein, the basic amino acid is selected from arginine, histidine or lysine, or one or more of their derivatives, or plant-extracted amino acids containing the aforementioned basic amino acids, including sesame amino acids, apple amino acids, corn amino acids, wheat amino acids or other plant amino acids.

[0019] The preparation method of the encapsulated supramolecular oil control and antibacterial composition of the present invention is as follows: adding basic amino acids, organic acids and cyclodextrins into water to form a mixed solution, stirring until transparent and uniform to obtain an encapsulated supramolecular organic acid aqueous solution, and drying and dehydrating the aqueous solution to obtain the encapsulated supramolecular oil control and antibacterial composition.

[0020] Furthermore, the mixed solution is stirred at a certain temperature, such as 30-80°C, preferably 40-70°C, and more preferably 50-60°C.

[0021] Furthermore, the drying and dehydration adopts a spray drying method, and the aqueous solution is dried to remove water to obtain the powder of the oil-controlling and antibacterial composition. Preferably, the water content of the obtained powder is controlled to be less than 5%.

[0022] According to the above preparation method, a powder of the encapsulated supramolecular oil-controlling and antibacterial composition can be obtained after dehydration. The encapsulated supramolecular oil-controlling and antibacterial composition can also be made into an aqueous solution in practical applications, and the drying and dehydration steps can be omitted. Furthermore, in the above preparation method, the solid-liquid ratio of the mixed liquid can be controlled, such as the ratio of solid matter to water is 10:90-90:10, preferably 50:50-80:20, and more preferably 60:40-70:30, to prepare an encapsulated supramolecular organic acid aqueous solution.

[0023] Based on the oil-controlling and antibacterial composition, whether it is a powder or an aqueous solution thereof, a cosmetic intermediate with oil-controlling and antibacterial effects can be obtained, which contains the encapsulated supramolecular oil-controlling and antibacterial composition.

[0024] The cosmetic intermediate may further include a chelating agent and / or an antioxidant. The chelating agent includes but is not limited to tetrasodium glutamate diacetate, trisodium dihydroxymethylalanine, EDTA2Na, EDTA4Na, etc.; the antioxidant includes but is not limited to sodium bisulfite, sodium pyrosulfite, VE acetate, etc.

[0025] The present invention also relates to the application of the encapsulated supramolecular oil control and antibacterial composition in cosmetics. The encapsulated supramolecular oil control and antibacterial composition can be used in personal care products, including but not limited to shampoo, conditioner, facial cleansing products, bath products, hand washing products; it can also be applied to skin care products, beauty cosmetics, makeup removal products, sunscreen products, etc. The product dosage forms used include but are not limited to water, emulsion, cream, powder, spray, foam, etc.

[0026] The encapsulated supramolecular oil-control and antibacterial composition of the present invention has good water solubility, low irritation, easy compatibility, and completely maintains the activity or efficacy of the functional components therein, and the synergistic effect between the compounded components enables the composition to exhibit better oil-control and antibacterial effects. The composition can be used in cosmetics without the assistance of a large amount of organic solvents and surfactants, and is particularly suitable for the later application of cosmetics and personal care products, and has the advantages of high bioavailability and difficulty in precipitation of organic acid crystals in later products.

[0027] Beneficial effects: The present invention utilizes the molecular characteristics of cyclodextrin molecules with annular cavities, and can form cyclodextrin inclusion complexes with supramolecular organic acids. The main molecule has a large cavity structure, which is sufficient to accommodate the guest molecule, the supramolecular organic acid formed by basic amino acids and specific organic acids, to form a molecular capsule. Through this molecular encapsulation, supramolecular organic acids have better water solubility, low irritation, higher bioavailability and other advantages, and can improve the inhibition rate of organic acids such as capryloyl glycine and salicylic acid on harmful bacteria such as acne bacteria and Malassezia, and improve the efficacy of capryloyl glycine, salicylic acid, etc. in combating acne, dandruff, excessive oil secretion and other problems. The organic acids capryloyl glycine, salicylic acid, etc. can play a synergistic role through compounding, and their oil control and antibacterial effects are better. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 Dark field photos of the encapsulated supramolecular oil-control and antibacterial composition (left) and the unencapsulated salicylic acid supramolecular (right) under a polarizing microscope;

[0029] Figure 2 Antibacterial effects of transparent shampoos containing different oil-controlling and antibacterial components on Malassezia furfur (1:10 dilution), wherein the oil-controlling and antibacterial components are (a) encapsulated supramolecular salicylic acid / octanoyl glycine composition, (b) unencapsulated supramolecular salicylic acid, and (c) salicylic acid monomer. DETAILED DESCRIPTION

[0030] Example 1

[0031] The encapsulated supramolecular oil-controlling and antibacterial composition is a cyclodextrin inclusion compound, which is composed of the following components in parts by weight: 24 parts of salicylic acid, 6 parts of capryloylglycine, 15 parts of arginine, 15 parts of histidine, and 40 parts of hydroxypropyl beta-cyclodextrin.

[0032] The cyclodextrin inclusion complex consists of a main molecule and a guest molecule included in the main molecule, wherein the main molecule is hydroxypropyl beta-cyclodextrin and the guest molecule is a supramolecular salicylic acid / supramolecular octanoyl glycine composed of salicylic acid, octanoyl glycine, arginine and histidine.

[0033] The preparation method is as follows: 15 parts of histidine, 15 parts of arginine, 40 parts of hydroxypropyl β-cyclodextrin, 24 parts of salicylic acid, and 6 parts of capryloyl glycine are mixed and stirred in water, maintained at 65°C, and stirred until the solid is completely dissolved to obtain a transparent solution, and the ratio of solid matter to water is 2:1; the aqueous solution is then spray-dried to remove water to obtain a powder, and the water content of the obtained powder is controlled to be less than 5%, thereby obtaining a supermolecular salicylic acid / capryloyl glycine oil control and antibacterial composition. The pH value of a 10% aqueous solution of the supermolecular salicylic acid / capryloyl glycine oil control and antibacterial composition is 5.0.

[0034] From the appearance, the obtained solid does not contain any crystalline form of the supramolecular oil-controlling and antibacterial composition, and is close to the appearance of glass; the dark field under the polarizing microscope is amorphous ( Figure 1 ), which is an isotropic structural feature and a non-crystalline structure. The unencapsulated salicylic acid, octanoyl glycine or salicylic acid and octanoyl glycine supramolecular has crystalline appearance, and the crystal form can be seen under the dark field of polarizing microscope, which is an anisotropic crystal structure feature.

[0035] Example 2

[0036] The encapsulated supramolecular oil-controlling and antibacterial composition is a cyclodextrin inclusion compound, which is composed of the following components in parts by weight: 30 parts of salicylic acid, 20 parts of capryloylglycine, 30 parts of histidine, and 20 parts of gamma-cyclodextrin.

[0037] The cyclodextrin inclusion compound consists of a main molecule and a guest molecule included in the main molecule, wherein the main molecule is gamma-cyclodextrin and the guest molecule is a supramolecular organic acid composed of salicylic acid, capryloylglycine and histidine.

[0038] The preparation method is as follows: Stir a mixture of 30 parts of histidine, 20 parts of capryloyl glycine, 30 parts of salicylic acid, and 20 parts of γ-cyclodextrin in water, maintain 60°C, and continue stirring until a transparent solution is obtained. The ratio of solid matter to water is 1:1. The aqueous solution is then dried to remove water to obtain a powder. The water content of the obtained powder is controlled to be less than 5%. The encapsulated supramolecular oil control and antibacterial agent is obtained. The pH value of the 10% solution of the obtained encapsulated supramolecular salicylic acid is 5.8.

[0039] Example 3

[0040] The encapsulated supramolecular oil-controlling and antibacterial composition is a cyclodextrin inclusion compound, which is composed of the following components in parts by weight: 40 parts of salicylic acid, 5 parts of capryloylglycine, 15 parts of lysine, 25 parts of arginine, and 15 parts of hydroxypropyl beta-cyclodextrin.

[0041] The cyclodextrin inclusion compound consists of a main molecule and a guest molecule included in the main molecule, wherein the main molecule is hydroxypropyl beta-cyclodextrin, and the guest molecule is a supramolecular organic acid composed of salicylic acid, capryloylglycine, lysine and arginine.

[0042] The preparation method is as follows: 15 parts of lysine, 25 parts of arginine, 15 parts of hydroxypropyl β-cyclodextrin, 40 parts of salicylic acid, and 5 parts of capryloyl glycine are stirred and dissolved in 50 parts of water, maintained at 70°C, and stirred until the solid is completely dissolved to obtain a transparent uniform solution, which is an aqueous solution encapsulating the supramolecular oil control and antibacterial composition. The pH value of the aqueous solution is 5.1.

[0043] Example 4

[0044] The encapsulated supramolecular oil-controlling and antibacterial composition is a cyclodextrin inclusion compound, which is composed of the following components in parts by weight: 20 parts of salicylic acid, 20 parts of azelaic acid, 10 parts of capryloylglycine, 30 parts of arginine, and 20 parts of hydroxypropyl beta-cyclodextrin.

[0045] The cyclodextrin inclusion compound consists of a main molecule and a guest molecule included in the main molecule, the main molecule is hydroxypropyl beta-cyclodextrin, and the guest molecule is a supramolecular organic acid composed of salicylic acid, azelaic acid, capryloylglycine and arginine.

[0046] The preparation method is as follows: 30 parts of arginine, 20 parts of hydroxypropyl β-cyclodextrin, 20 parts of salicylic acid, 20 parts of azelaic acid, and 10 parts of capryloyl glycine are stirred in water, maintained at 70°C, and stirred until the solid is completely dissolved to obtain a transparent uniform solution, the aqueous solution is spray-dried to obtain a powder, and the water content of the obtained powder is controlled to be less than 5%, that is, the supramolecular salicylic acid, supramolecular azelaic acid, and supramolecular capryloyl glycine oil control and antibacterial composition is encapsulated. The pH value of a 10% aqueous solution of the encapsulated supramolecular oil control and antibacterial composition is 5.2.

[0047] Example 5

[0048] The encapsulated supramolecular oil-controlling and antibacterial composition is a cyclodextrin inclusion compound, which is composed of the following components in parts by weight: 35 parts of succinic acid, 45 parts of arginine, and 20 parts of hydroxypropyl γ-cyclodextrin. The cyclodextrin inclusion compound is composed of a main molecule and a guest molecule included in the main molecule, the main molecule is hydroxypropyl γ-cyclodextrin, and the guest molecule is a supramolecular succinic acid composed of succinic acid, lysine and arginine.

[0049] The preparation method is as follows: 45 parts of arginine, 20 parts of hydroxypropyl γ-cyclodextrin, and 35 parts of succinic acid are stirred in water, maintained at 70°C, and stirred until the solid is completely dissolved to obtain a transparent uniform solution, and then the solution is spray-dried to obtain a powder, and the water content of the obtained powder is controlled to be less than 5% to obtain a supermolecular succinic acid oil control and antibacterial composition. The pH value of a 10% aqueous solution of the supermolecular succinic acid oil control and antibacterial composition is 5.0.

[0050] Example 6

[0051] The encapsulated supramolecular oil-controlling and antibacterial composition is a cyclodextrin inclusion compound, which is composed of the following components in parts by weight: 40 parts of salicylic acid, 45 parts of histidine, and 15 parts of hydroxypropyl γ-cyclodextrin. The cyclodextrin inclusion compound is composed of a main molecule and a guest molecule included in the main molecule, the main molecule is hydroxypropyl γ-cyclodextrin, and the guest molecule is a supramolecular salicylic acid composed of salicylic acid and histidine.

[0052] The preparation method is as follows: 45 parts of histidine, 15 parts of hydroxypropyl γ-cyclodextrin, and 40 parts of salicylic acid are stirred in water, maintained at 60°C, and stirred until the solid is completely dissolved to obtain a transparent uniform solution, and then the solution is spray-dried to obtain a powder, and the water content of the obtained powder is controlled to be less than 5% to obtain a supramolecular salicylic acid-encapsulated oil-control and antibacterial composition. The pH value of a 10% aqueous solution of the supramolecular salicylic acid-encapsulated oil-control and antibacterial composition is 4.7.

[0053] Comparative Example 1

[0054] The supramolecular salicylic acid composition consists of the following components in parts by weight: 40 parts of salicylic acid, 45 parts of histidine and 15 parts of dextran.

[0055] The preparation method is as follows: 45 parts of histidine, 40 parts of salicylic acid, and 15 parts of dextran are stirred in water, maintained at 85°C, and stirred until the solid is completely dissolved to obtain a transparent solution, and then the aqueous solution is spray-dried to remove water to obtain a powder, and the water content of the obtained powder is controlled to be less than 5% to obtain a non-encapsulated supramolecular salicylic acid composition. The pH value of a 10% aqueous solution of the non-encapsulated supramolecular salicylic acid is 4.75.

[0056] Example 7

[0057] The encapsulated supramolecular oil control and antibacterial composition of Example 1, the supramolecular salicylic acid and salicylic acid monomer of Comparative Example 1 were applied to a transparent amino acid surfactant shampoo, and the shampoo formula is as shown in Table 1:

[0058] Table 1

[0059]

[0060] The antibacterial rate of the above three shampoo samples was tested, and the test strain was Malassezia furfur.

[0061] The test method is in accordance with QB / T 2738-2012 Evaluation method for antibacterial and antimicrobial effects of daily chemical products. The test strain sample is a 1:10 water dilution of the strain stock solution. The test results are attached. Figure 2 The results showed that the antibacterial rate of shampoo with the encapsulated supramolecular oil-control and antibacterial composition was 96.86%, the antibacterial rate of shampoo with unencapsulated supramolecular salicylic acid was 15.2%, and the antibacterial rate of shampoo with salicylic acid monomer was only 7%. Although the antibacterial rate of unencapsulated supramolecular salicylic acid was higher than that of salicylic acid monomer, the antibacterial rates of both against Malassezia furfur were less than 20%.

[0062] Example 8

[0063] The relative expression level analysis of oil secretion genes was tested on the shampoo of formula 1 in Example 7.

[0064] Test principle: Sebaceous glands secrete a mixture of various lipids, including squalene, monoester wax, free fatty acids, triglycerides, diesters of glycerol ethers, cholesterol and cholesterol esters, etc. They come to the surface of the skin through the hair follicles to form what we call "oil" in daily life, also called free sebum. In the laboratory, by testing the effect of oil-control shampoo on the activity of human sebaceous gland cells, the effectiveness of oil-control shampoo in controlling scalp oil secretion can be indirectly determined. Adding oil inducers (DHT) can induce the enhancement of sebaceous gland cell activity. On the contrary, if oil-control shampoo is added after the oil inducer is added to induce the enhancement of sebaceous gland cells, if the activity of sebaceous cells can be re-inhibited, it can be shown that oil-control shampoo can effectively inhibit oil secretion.

[0065] Compared with the blank group, the model group was added with oil inducer (DHT), and the average expression level of the model group exceeded that of the blank control group, indicating that the data of the model group has reference value; while the test group added 0.016% of the oil control and anti-dandruff shampoo of Example 7 on the basis of containing the same amount of oil inducer (DHT), and the results are shown in Table 2. Its average expression level is significantly lower than that of the model group, indicating that the oil control shampoo has oil control effect.

[0066] Table 2. Statistical results of sample experimental group and blank control group

[0067]

[0068] According to the data analysis results, the oil secretion gene in the experimental group using the test product of Example 7 was significantly reduced compared with the model group not using the test product (P<0.05), and the shampoo of Example 7 has a significant oil control effect.

[0069] After the experimental group used the shampoo product with the oil-control and anti-dandruff composition, the oil secretion gene was significantly lower than that of the model control group, and the statistical difference was P<0.05, indicating a significant difference.

[0070] Example 9

[0071] A cosmetic intermediate with oil-controlling and antibacterial effects, comprising:

[0072] 100 copies of the encapsulated supramolecular oil-controlling and antibacterial composition of Example 1

[0073] 0.1 parts of tetrasodium glutamate diacetate

[0074] 0.1 parts of sodium bisulfite.

[0075] The above description is only used to illustrate the technical solution of the present invention rather than to limit it. Other modifications or equivalent substitutions made to the technical solution of the present invention by ordinary technicians in this field should be included in the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solution of the present invention.

Claims

1. A supramolecular oil-controlling and antibacterial composition, characterized in that: The invention is composed of an organic acid, a basic amino acid and cyclodextrin, wherein the organic acid is selected from salicylic acid and capryloylglycine, the mass ratio of salicylic acid to capryloylglycine is 1:10-10:1, and the basic amino acid is selected from one or more of arginine, histidine or lysine, wherein the organic acid and the basic amino acid are connected by hydrogen bonds to form a supramolecular organic acid, and the composition contains a cyclodextrin inclusion complex formed by cyclodextrin encapsulating the organic acid supramolecular.

2. The encapsulated supramolecular oil-controlling and antibacterial composition according to claim 1, characterized in that: The mass ratio of the organic acid to the basic amino acid is 1:10-10:

1.

3. The encapsulated supramolecular oil-controlling and antibacterial composition according to claim 1, characterized in that: The mass ratio of the supramolecular organic acid to cyclodextrin is 1:20-20:

1.

4. The encapsulated supramolecular oil-controlling and antibacterial composition according to claim 1, characterized in that: The cyclodextrin is α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin or a derivative thereof.

5. A method for preparing the encapsulated supramolecular oil-controlling and antibacterial composition according to claim 1, characterized in that: Basic amino acid, organic acid and cyclodextrin are added into water to form a mixed solution, and stirred until transparent and uniform to obtain an encapsulated supramolecular organic acid aqueous solution, and the aqueous solution is dried and dehydrated to obtain the encapsulated supramolecular oil control and antibacterial composition.

6. A cosmetic intermediate, characterized in that: The invention comprises the encapsulated supramolecular oil-controlling and antibacterial composition according to claim 1.

7. The cosmetic intermediate according to claim 6, characterized in that: These may contain chelating agents and / or antioxidants.

8. Use of the encapsulated supramolecular oil-controlling and antibacterial composition according to claim 1 in cosmetics.

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