A mixed virus sampling and extraction tube

Abstract

This invention belongs to the field of medical testing supplies technology, specifically relating to a mixing-type virus sampling and extraction tube. The tube includes a tube body with an opening at the top, the top of which is covered with a sealing film. A cap is connected to the top of the tube body for sealing the top. The cap has a dropper nozzle with a drip channel communicating with the inside of the tube body. A side channel is also provided inside the dropper nozzle, communicating with the drip channel. A trachet is located on the cap, passing through the drip channel and the side channel. The outer diameter of the trachet is smaller than the inner diameter of the drip channel. One end of the trachet is connected to an air bladder, and the other end is connected to an inflation bladder. The air bladder and inflation bladder are located on opposite sides of the cap. In this invention, the air bladder is inflated / deflated, causing a change in its volume, which in turn compresses and stirs the test solution inside the tube body, ensuring uniform mixing of the sample and lysis buffer and guaranteeing accurate test results.

Description

Technical Field

[0001] This invention belongs to the field of medical testing supplies technology, specifically relating to a mixed virus sampling and extraction tube. Background Technology

[0002] Currently, common virus sampling and extraction tubes on the market typically consist of a tube body, a cap, and a sealing film, with a dropper also attached to the cap. In use, the user first removes the sealing film from the tube body to expose the tube opening. Then, the swab head containing the sample is inserted into the tube body, and the sample is stirred with the swab to mix with the pre-filled lysis buffer inside the tube body. After stirring for at least 30 seconds, the swab is removed, the cap is placed back on the tube opening, and the tube is inverted. The test solution inside the tube drips from the dropper into the sample well of the test card. The test results are observed within 15–20 minutes.

[0003] The above process requires the user to insert the swab into the tube and stir it. Due to the user's lack of experience, the sample on the swab tip is not mixed evenly with the lysis buffer while rotating the swab, leading to inaccurate test results. Furthermore, because the tube opening is open during stirring, environmental contaminants can easily enter the tube and contaminate the test solution. Therefore, there is a need for a virus sampling and extraction tube that allows users to easily achieve uniform mixing. Summary of the Invention

[0004] The present invention aims to provide a mixed-mode virus sampling and extraction tube to solve the problem of uneven mixing of samples and lysis buffer during the use of existing virus sampling and extraction tubes.

[0005] To achieve the above objectives, the present invention provides a mixed-type virus sampling and extraction tube, comprising a tube body with an opening at the top and a sealing film covering the top of the tube body. A cap for sealing the top of the tube body is connected to the top of the tube body. A nozzle is provided on the cap, and the nozzle has an internal dripping channel that communicates with the internal structure of the tube body. A side channel is also provided inside the nozzle, communicating with the dripping channel. An air tube is provided on the cap, penetrating the dripping channel and the side channel. The outer diameter of the air tube is smaller than the inner diameter of the dripping channel. One end of the air tube is connected to an air-inflating bladder, and the other end is connected to an inflatable bladder. The air-inflating bladder and the inflatable bladder are located on opposite sides of the cap.

[0006] The working principle and beneficial effects of this scheme are as follows: After the swab head takes a sample, it is detached from the swab and falls into the tube body. The top of the tube body is sealed with a tube cap, and the air bladder is moved down into the lysis solution. The air bladder is inflated / deflated to change its volume, thereby squeezing and stirring the test liquid in the tube body, so that the sample and the lysis solution are mixed evenly, ensuring the accuracy of the test results.

[0007] Furthermore, in this solution, the user can achieve squeezing and mixing by manually squeezing the inflation bladder intermittently, without the need to rotate the swab for stirring, making the operation simpler and more convenient. Moreover, since the squeezing and mixing in this solution occurs after the tube cap seals the top of the tube, external contaminants are difficult to enter the tube, thus preventing contamination of the test solution. Additionally, if the user does not hold the tube securely and it slips, the test solution inside the tube will not leak out or will only leak a small amount, allowing the testing to continue.

[0008] Optionally, the air bladder is provided with a protective sleeve, which is used to protect the air bladder and part of the air tube.

[0009] In this design, the protective cover protects the air bladder and part of the air tube, so that the air bladder and part of the air tube are only exposed to the air after the protective cover is removed. This effectively prevents the air bladder from coming into contact with contaminants (such as the user's fingers), thereby effectively preventing the air bladder from being contaminated before use and thus preventing contamination of the lysis fluid.

[0010] Optionally, the outer diameter of the trachea is equal to the inner diameter of the side branch channel.

[0011] In this scheme, the outer diameter of the trachea is equal to the inner diameter of the side channel. In this way, the trachea can block the side channel to a certain extent. When the tube is inverted, the test liquid cannot flow out through the side channel, but only drips into the sample air of the test card through the drip channel.

[0012] Optionally, the pipe cap is provided with a wall-adhesive tube, which fits against the inner wall of the top of the pipe body after the pipe cap seals the pipe.

[0013] In this design, the wall-mounted tube fits against the inner wall of the top of the tube body after the tube cap seals the tube body, thereby increasing the contact area between the tube cap and the tube body, and thus increasing the connection force between the tube cap and the tube body, preventing the tube cap from spontaneously detaching from the tube body.

[0014] Optionally, the tube attached to the wall has a protrusion, and the protrusion has a groove, the width of which is greater than or equal to the diameter of the swab.

[0015] This method requires breaking the swab head off the swab. Therefore, after the swab head carries the sample, insert the swab into the slot of the protrusion. With a little force, the swab head can be detached from the swab and fall directly into the tube body. The operation is convenient and simple.

[0016] Optionally, the protrusion is located at one end of the tube closest to the tube body.

[0017] In this design, the protrusion is located at the end of the tube closest to the tube body, which allows the swab head to partially penetrate the tube body before the swab is broken off, thus ensuring that the swab head falls smoothly into the tube body after being removed from the swab.

[0018] Optionally, the air bladder is elongated.

[0019] In this design, the air bladder is elongated and can fully compress the swab head, thereby ensuring that the sample on the swab head is thoroughly mixed with the lysis solution in the tube.

[0020] Optionally, the inflatable bladder is made of plastic, and the initial volume of the inflatable bladder is larger than the initial volume of the blister bladder.

[0021] In this design, the inflatable bladder is made of plastic, which is inexpensive and has low elasticity, making it easy for the user to squeeze the bladder to transfer air from inside the bladder to the inflatable bladder via the air tube. Furthermore, when the bladder is not squeezed, air is well stored within it and does not spontaneously flow into the inflatable bladder, thus ensuring a small initial volume of the inflatable bladder, allowing it to enter the tube smoothly without affecting subsequent dripping.

[0022] Optionally, the pipe cap is connected to the top of the pipe body by an anti-detachment rib.

[0023] In this design, the cap is connected to the top of the tube body via an anti-detachment rib, thus ensuring sufficient distance between the cap and the tube body, making it easy for the user to close the cap onto the top of the tube body.

[0024] Optionally, the number of anti-detachment ribs is two, and the two anti-detachment ribs are located at both ends of the pipe cap.

[0025] In this design, there are two anti-detachment ribs, which are located at both ends of the pipe cap to enhance the connection strength between the pipe cap and the pipe body. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of the structure of a mixing-type virus sampling and extraction tube according to Embodiment 1 of the present invention;

[0027] Figure 2 This is a partial longitudinal cross-sectional view of a mixing-type virus sampling and extraction tube according to Embodiment 1 of the present invention;

[0028] Figure 3 for Figure 1 A top view (trachea, bladder, and inflation bag are not shown);

[0029] Figure 4 This is a longitudinal sectional view of the tube body, tube cap, and drip tip in Embodiment 1 of the present invention;

[0030] Figure 5 This is a schematic diagram of the structure of the swab in Embodiment 1 of the present invention;

[0031] Figure 6This is a schematic diagram of the structure when the tube cap is closed on the top of the tube body in Embodiment 1 of the present invention;

[0032] Figure 7 This is a schematic diagram of the structure of a mixing-type virus sampling and extraction tube in Embodiment 2 of the present invention. Detailed Implementation

[0033] The following detailed description illustrates the specific implementation method:

[0034] The markings in the accompanying drawings of the instruction manual include: tube body 1, sealing film 2, anti-detachment rib 3, tube cap 4, dropper 5, drip channel 6, side channel 7, trachea 8, air bladder 9, inflation bladder 10, wall-mounted tube 11, protrusion 12, slot 13, swab 14, swab head 141, break point 142, and protective sleeve 15.

[0035] Example 1

[0036] This embodiment is basically as follows: Figure 1 and Figure 2 As shown: A mixing-type virus sampling and extraction tube includes a tube body 1 with an opening at the top. The top of the tube body 1 is covered with a sealing film 2. In this embodiment, the sealing film 2 is made of aluminum foil. A tube cap 4 for sealing the top of the tube body 1 is connected to the top of the tube body 1 via an anti-detachment rib 3. Figure 3 As shown, there are two anti-detachment ribs 3, and the two anti-detachment ribs 3 are located at both ends of the tube cap 4. The tube cap 4 is provided with a drip nozzle 5, and the inside of the drip nozzle 5 has a dripping channel 6 that can communicate with the inside of the tube body 1. Figure 4 As shown, the nozzle 5 also has a side channel 7 inside, which is connected to the dripping channel 6. In this embodiment, the tube body 1, the anti-detachment rib 3, and the tube cap 4 are integrally injection molded.

[0037] Combination Figure 1 and Figure 2 As shown, the cap 4 is equipped with an air tube 8, which passes through the dripping channel 6 and the side channel 7. The outer diameter of the air tube 8 is smaller than the inner diameter of the dripping channel 6. Moreover, in this embodiment, the outer diameter of the air tube 8 is equal to the inner diameter of the side channel 7. Thus, the air tube 8 can effectively block the side channel 7 and can also move within the side channel 7. In this embodiment, the air tube 8 is a plastic tube with a certain degree of flexibility and can be bent. The top end of the air tube 8 is connected to an air bladder 9, and the bottom end of the air tube 8 is connected to an air bladder 10. The initial volume of the air bladder 10 is larger than the initial volume of the air bladder 9. The air bladder 9 is made of rubber, so it has good elasticity, expands when inflated, and automatically contracts when deflated. In addition, in this embodiment, the air bladder 9 is elongated; while the air bladder 10 is made of plastic, so it has weak elasticity. When the user does not squeeze the air bladder 10, the air inside the air bladder 10 will not be transferred to the air bladder 9 through the air tube 8.

[0038] The upper surface of the cap 4 is provided with a wall-adhering tube 11, which adheres to the inner wall of the top of the tube body 1 where the cap 4 seals the top. In this embodiment, the wall-adhering tube 11 and the cap 4 are integrally injection molded. A protrusion 12 is provided on one end of the wall-adhering tube 11 near the tube body 1. In this embodiment, the protrusion 12 is integrally molded with the wall-adhering tube 11. A groove 13 is provided on the protrusion 12, the width of which is greater than or equal to the diameter of the swab 14 (the structure of the swab 14 is as follows). Figure 5 As shown in the figure, in this embodiment, the width of the slot 13 is equal to the diameter of the swab 14.

[0039] During use, after disinfecting their hands, the user removes the tube body 1 from the extraction tube packaging bag and takes out the swab 14 from the swab 14 packaging bag. The user then uses their right thumb and forefinger to hold the swab 14 and collect the sample (the sample is attached to the swab head 141). Subsequently, the user presses the tube body 1 between the thenar eminence of their right hand using their middle and forefinger fingers, and uses their left hand to tear off the sealing film 2 at the top of the tube body 1, exposing the opening at the top of the tube body 1. Then, the tube body 1 is switched to the user's left hand. Specifically, the user's left middle and ring fingers hold the tube body 1, and the left thumb and index finger pinch the tube cap 4, so that the plane of the tube cap 4 is perpendicular to the horizontal plane of the top of the tube body 1. Then, the swab 14 held in the right hand is inserted into the slot 13 of the protrusion 12. The swab 14 has a break point 142, which is close to the swab head 141 and is located 2mm above the slot 13. Force is applied so that the swab 14 breaks at the break point 142, and the swab head 141 naturally falls into the tube body 1.

[0040] Then, the user inserts the air bladder 9 into the tube body 1, and then closes the tube cap 4 onto the top of the tube body 1, ensuring that the outer peripheral wall of the tube 11 fits against the inner peripheral wall of the top of the tube body 1 to prevent the tube cap 4 from spontaneously detaching from the tube body 1. At this time, if the air bladder 9 is above the swab head 141, the user manually pushes the air tube 8 to move the air bladder 9 downwards until the end of the air bladder 9 contacts the swab head 141. Figure 6 As shown. Next, the user manually squeezes the inflation bladder 10. The air inside the inflation bladder 10 flows into the diaphragm 9 through the trachea 8, increasing the air volume and thus squeezing and agitating the swab head 141 and lysis solution inside the tube body 1. When the patient stops squeezing the inflation bladder 10, the diaphragm 9 automatically contracts, and the air inside the diaphragm 9 flows back into the inflation bladder 10 through the trachea 8. In this way, by squeezing the inflation bladder 10 more than thirty times, the swab head 141 and lysis solution inside the tube body 1 can be squeezed and agitated more than thirty times, thereby ensuring that the sample on the swab head 141 is fully mixed with the lysis solution to obtain a homogeneous test solution.

[0041] Finally, the user inverts tube 1, and the test solution inside tube 1 flows out through the drip channel 6 and drips into the sample hole of the test card (4 drops of test solution). The test results are observed within 15-20 minutes. During the dripping process, because the trachea 8 blocks the side channel 7, the test solution will not flow out from the side channel 7, thus preventing the test solution from dripping outside the sample hole of the test card.

[0042] In addition, if, during the dripping of the test solution, after 3 drops of the test solution have been dripped, the last drop of the test solution cannot be dripped, the user can squeeze the air bladder 10 to increase the volume of the air bladder 9 and squeeze the swab head 141, so that the test solution absorbed on the swab head 141 is squeezed out, thus forming the last drop of the test solution, and successfully dripping out 4 drops of the test solution, without having to manually squeeze the tube body 1 and then squeeze the swab head 141.

[0043] In summary, this embodiment utilizes the volume change caused by the inflation / deflation of the air bladder 9 to achieve compression and stirring of the sample and lysis buffer. This avoids the need for the user to stir the lysis buffer by rotating the swab 14, ensuring uniform mixing of the sample and lysis buffer and thus guaranteeing the accuracy of the test results. Furthermore, because the cap 4 seals the top of the tube body 1 during the compression and stirring process, external contaminants are difficult to enter the tube body 1, preventing contamination of the test solution. Moreover, in this embodiment, if the user does not hold the tube body 1 securely during the compression and stirring process, causing it to slip, the test solution inside the tube body 1 will not leak out or will only leak slightly, allowing the test to continue. Therefore, the extraction tube in this embodiment has good safety and practicality, making it suitable for widespread use.

[0044] Additionally, it should be noted that the extraction tube in this embodiment can also be used for the detection of colloidal gold in other samples, such as fecal occult blood. Simply replace the swab in this embodiment with a sampling spoon, and the other operations are the same as in this embodiment.

[0045] Example 2

[0046] The difference between this embodiment and Embodiment 1 is that: Figure 7 As shown, in this embodiment, the air bladder 9 is provided with a protective sleeve 15, which is used to protect the air bladder 9 and part of the air tube 8. The protective sleeve 15 is a long strip of plastic sleeve that covers the air bladder 9 and the 2cm long air tube 8 connected to the air bladder 9, thereby protecting the air bladder 9 and the part of the air tube 8 and preventing the air bladder 9 from being contaminated by the outside before contacting the lysis solution.

[0047] Therefore, in this embodiment, after the user breaks the swab 14 and the swab head 141 falls into the tube body 1, the protective cover 15 is removed to expose the air bladder 9. Then the air bladder 9 is placed into the tube body 1 and the tube cap 4 is placed on the top of the tube body 1. The rest of the operation is the same as in Embodiment 1.

[0048] The above are merely embodiments of the present invention. The invention is not limited to the fields covered by these embodiments. Commonly known structures and characteristics are not described in detail here. Those skilled in the art are aware of all common technical knowledge in the field prior to the application date or priority date, are aware of all existing technologies in that field, and have the ability to apply conventional experimental methods prior to that date. Those skilled in the art can improve and implement this solution based on the guidance provided in this application and their own capabilities. Some typical known structures or methods should not be obstacles for those skilled in the art to implement this application. It should be noted that those skilled in the art can make several modifications and improvements without departing from the structure of the present invention. These should also be considered within the scope of protection of the present invention, and will not affect the effectiveness or practicality of the invention. The scope of protection claimed in this application should be determined by the content of its claims. The specific embodiments described in the specification can be used to interpret the content of the claims.

Claims

1. A mixing-type virus sampling and extraction tube, comprising a tube body, an opening at the top of the tube body, and a sealing film covering the top of the tube body; a cap connected to the top of the tube body for sealing the top of the tube body; a dropper nozzle on the cap; and a dropper nozzle having an internal dripping channel communicating with the interior of the tube body, characterized in that: The nozzle also has a side channel inside, which is connected to the drip channel. The cap has an air tube that runs through the drip channel and the side channel. The outer diameter of the air tube is smaller than the inner diameter of the drip channel. One end of the air tube is connected to an air bladder, and the other end is connected to an inflation bladder. The air bladder and the inflation bladder are located on opposite sides of the cap. When the cap is closed on the top of the tube, the air bladder is located inside the tube. The air bladder is more elastic than the inflation bladder. The air bladder expands when inflated and automatically contracts when deflated. When the user does not squeeze the inflation bladder, the air inside the inflation bladder will not be transferred to the air bladder through the air tube.

2. The mixed virus sampling and extraction tube according to claim 1, characterized in that: The air bladder is covered with a protective sleeve, which is used to protect the air bladder and part of the air tube.

3. The mixed virus sampling and extraction tube according to claim 1 or 2, characterized in that: The outer diameter of the trachea is equal to the inner diameter of the side branch passage.

4. The mixed virus sampling and extraction tube according to claim 1, characterized in that: The pipe cap is provided with a wall-adhesive tube, which fits against the inner wall of the top of the pipe body after the pipe cap seals the pipe.

5. The mixing-type virus sampling and extraction tube according to claim 4, characterized in that: The tube attached to the wall has a protrusion, and the protrusion has a slot, the width of which is greater than or equal to the diameter of the swab.

6. The mixed virus sampling and extraction tube according to claim 5, characterized in that: The protrusion is located at the end of the wall-mounted pipe closest to the pipe body.

7. The mixing-type virus sampling and extraction tube according to claim 1, characterized in that: The air bladder is elongated.

8. The mixed virus sampling and extraction tube according to claim 1, characterized in that: The inflatable bladder is made of plastic, and the initial volume of the inflatable bladder is larger than the initial volume of the blister bladder.

9. The mixing-type virus sampling and extraction tube according to claim 1, characterized in that: The pipe cap is connected to the top of the pipe body by an anti-detachment rib.

10. The mixing-type virus sampling and extraction tube according to claim 9, characterized in that: The number of anti-detachment ribs is two, and the two anti-detachment ribs are located at both ends of the pipe cap.

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