A nanomagnetic bead separator

Abstract

The present invention discloses a nanomagnetic bead separator, comprising a test tube rack, the test tube rack comprising a plastic support and a magnet assembly, the plastic support being provided with a plurality of test tube holes, test tubes for accommodating magnetic beads being inserted into the test tube holes, and a magnet assembly for separating the magnetic beads, the magnet assembly comprising a plurality of magnetic steel assemblies, each magnetic steel assembly being arranged correspondingly to a corresponding test tube, and the magnetic field of each magnetic steel assembly affecting the corresponding test tube so that the nanomagnetic beads are separated to the side wall of the test tube. The magnet assembly of the present invention comprises a plurality of magnetic steel assemblies, each magnetic steel assembly being arranged correspondingly to a corresponding test tube, thereby enhancing the surface magnetic strength of the magnet assembly, thereby accelerating the separation rate of the nanomagnetic beads and improving the separation effect of the nanomagnetic beads.

Description

Technical Field

[0001] The present invention relates to the technical field of separation equipment, in particular to a nano magnetic bead separator. Background Art

[0002] Magnetic bead separation technology is a novel separation method based on surface-functionalized nanomagnetic beads as a separation medium. It is widely used in in vitro diagnostics and the biochemical industry. The principle is that magnetic beads, surface-modified with antibodies to target microorganisms, form magnetic bead-microorganism complexes due to the specific reaction between the antibody and antigen. These complexes are sensitive to external magnetic fields, adsorbing the complexes and removing free impurities, thereby purifying and enriching the target. The use of nanomagnetic beads for nucleic acid extraction or protein labeling relies on magnetic bead separators. Traditional magnetic bead separation devices are mostly suitable for 2ml centrifuge tubes. Some multifunctional magnetic stands are suitable for 2ml and 15ml centrifuge tubes, with a maximum capacity of 50ml. However, the larger the diameter of the separation tube, the higher the magnetic field strength required for nanomagnetic bead separation. Existing nanomagnetic bead separator test tube racks use a single piece of sintered NdFeB magnet placed close to the test tube, resulting in a surface magnetic field of only 3000-4000 GS. This not only slows the separation rate but also reduces the nanomagnetic bead separation effect. Summary of the Invention

[0003] The present application solves the problems of weak surface magnetic strength, slow separation rate of nanomagnetic beads and poor separation effect of the separator in the prior art by providing a nanomagnetic bead separator. It achieves the goal of enhancing the surface magnetic strength of the magnet assembly through a unique splicing method, thereby improving the separation efficiency and separation effect of the nanomagnetic beads.

[0004] To achieve the above-mentioned objectives, the present invention provides the following technical solutions: a nanomagnetic bead separator, comprising a test tube rack, the test tube rack comprising a plastic rack and a magnet assembly, the plastic rack being provided with a plurality of test tube holes, test tubes for accommodating magnetic beads being inserted into the test tube holes, the magnet assembly also comprising a plurality of magnetic steel assemblies, each magnetic steel assembly being arranged corresponding to a corresponding test tube, and the magnetic field of each magnetic steel assembly affecting the corresponding test tube so that the nanomagnetic beads are separated to the side wall of the test tube.

[0005] By adopting the above technical solution, the magnet assembly includes multiple magnetic steel assemblies, each magnetic steel assembly is arranged corresponding to the corresponding test tube, thereby enhancing the surface magnetic strength of the magnet assembly, thereby accelerating the separation rate of the nanomagnetic beads and improving the separation effect of the nanomagnetic beads.

[0006] The magnet assembly includes a first magnet assembly, which is arranged between two adjacent rows of test tube holes. The first magnet assembly includes multiple bar magnet steel assemblies, each bar magnet steel assembly corresponds to the test tube holes in the same row, and the magnetic field of each bar magnet steel assembly affects the adjacent test tubes in the same row.

[0007] By adopting the above technical solution, by arranging the first magnet assembly between two adjacent rows of test tube holes, the first magnet assembly can simultaneously affect the two adjacent rows of test tubes, while ensuring that the effect of the test tubes being affected by the magnetic field remains unchanged, while saving space in the test tube rack, and improving the utilization rate of the first magnet assembly. The first magnet assembly includes multiple bar magnet steel assemblies, each bar magnet steel assembly corresponds to the test tube holes in the same row, and two adjacent test tubes in the same row share the same bar magnet steel assembly, saving manufacturing costs and also making the magnetic field of each bar magnet steel assembly affect the adjacent test tubes in the same row separately, so that the nanomagnetic beads are separated to the inner wall of one side of the test tube, ensuring the separation rate and separation effect of the magnetic beads in each test tube.

[0008] The strip magnet assembly includes a first auxiliary magnet, a first magnetic core, a second auxiliary magnet, a second magnetic core, and a third auxiliary magnet that are vertically arranged and arranged in sequence. The specific splicing method of the strip magnet assembly is as follows: the magnetic pole directions of the first auxiliary magnet and the third auxiliary magnet are the same, and the magnetic pole directions of the first auxiliary magnet and the third auxiliary magnet are parallel to the central axis of the strip magnet assembly, and the magnetic pole direction of the second auxiliary magnet is opposite to the magnetic pole direction of the first auxiliary magnet; the first magnetic core includes a first magnetic crown provided at the upper end, a first magnetic base provided at the middle end, and a second magnetic crown provided at the lower end, and the first magnetic crown and the second magnetic crown are parallel to the central axis of the strip magnet assembly. The magnetic poles are arranged opposite to each other and perpendicular to the central axis. The first magnetic base includes two vertically arranged parts, and the magnetic field directions of the two parts of the first magnetic base are arranged opposite to each other, and the magnetic field directions of the two parts of the first magnetic base are perpendicular to the magnetic field direction of the first auxiliary magnet; the second magnetic core includes a third magnetic crown arranged at the upper end, a second magnetic base arranged at the middle end, and a fourth magnetic crown arranged at the lower end. The magnetic pole directions of the third magnetic crown and the fourth magnetic crown are arranged opposite to each other, and the second magnetic base includes two vertically arranged parts, and the magnetic field directions of the two parts of the second magnetic base are arranged opposite to each other, and the magnetic field directions of the two parts of the second magnetic base are perpendicular to the magnetic field direction of the first auxiliary magnet.

[0009] By adopting the above technical solution, the magnetic field directions of the two parts of the first magnetic base are set to face each other, and the magnetic field directions of the two parts of the second magnetic base are set to face each other. The remaining magnetic steels are shared, which saves space and manufacturing costs. By setting the angle of the magnetic field direction of each magnetic steel in the bar magnetic steel assembly, the magnetic field at the connection between the adjacent test tubes is enhanced. The enhanced magnetic field can realize rapid and efficient separation of nanomagnetic beads, so that the nanomagnetic beads are separated to the inner wall of one side of the test tube.

[0010] The positions of the first magnetic core and the second magnetic core correspond to the positions of the test tube. A first arc surface is provided at the connection between the first magnetic core and the test tube, and a second arc surface is provided at the connection between the second magnetic core and the test tube. The first arc surface and the second arc surface cooperate with the test tube.

[0011] By adopting the above technical solution, a first curved surface is provided at the connection between the first magnetic core and the test tube, and a second curved surface is provided at the connection between the second magnetic core and the test tube, so that the first magnetic core and the second magnetic core can better fit the outer wall, thereby improving the efficiency of the separator in separating nanomagnetic beads.

[0012] The magnet assembly includes a second magnet assembly, which includes multiple annular magnetic steel assemblies. The annular magnetic steel assemblies are arranged on a plastic bracket and below the test tube holes. Each annular magnetic steel assembly corresponds to each test tube hole and is coaxially arranged. The test tube is inserted into the central axis of the annular magnetic steel assembly through the test tube hole. The magnetic field of each annular magnetic steel assembly affects the corresponding test tube.

[0013] By adopting the above technical solution, the test tube is inserted into the central axis of the annular magnetic steel assembly through the test tube hole. Each annular magnetic steel assembly affects one test tube, so that the magnetic field effect of the annular magnetic steel assembly on the test tube is enhanced, thereby improving the separation efficiency of the nanomagnetic beads.

[0014] The annular magnetic steel assembly includes a plurality of magnetic tiles, which are in a strip shape. The annular magnetic steel assembly is formed by splicing the magnetic tiles. There are multiple ways to splice the annular magnetic steel assembly.

[0015] By adopting the above technical solution, several magnetic tiles are spliced ​​into a ring-shaped magnetic steel assembly, and the magnetic fields of different magnetic tiles are influenced by the magnetic fields, thereby enhancing the magnetic field effect on the test tube, thereby enhancing the separation rate and separation effect of the nanomagnetic beads in the test tube.

[0016] The first splicing method of the annular magnetic steel assembly is the first annular magnetic steel, which includes twelve magnetic tiles of the same shape. The first annular magnetic steel is spliced ​​by twelve magnetic tiles. The magnetic field directions of the relatively arranged magnetic tiles are the same, and the magnetic field direction of the first magnetic tile of the four adjacent magnetic tiles is rotated 180° clockwise along the clockwise direction of the first annular magnetic steel to become the magnetic field direction of the fourth magnetic tile, so that the magnetic field of the first annular magnetic steel in the inner diameter direction is enhanced at both poles.

[0017] By adopting the above technical solution, the magnetic field of the first annular magnet in the inner diameter direction is enhanced at both poles, so that the magnetic beads in the test tube can be separated at the two polar side walls of the test tube. The above method can improve the separation rate and separation effect of the magnetic beads in the test tube.

[0018] The second splicing method of the annular magnetic steel assembly is the second annular magnetic steel. The second annular magnetic steel includes eight magnetic tiles of the same shape. The second annular magnetic steel is spliced ​​by eight magnetic tiles. The magnetic field directions of the relatively arranged magnetic tiles are opposite, and the magnetic field direction of the first magnetic tile of the three adjacent magnetic tiles is rotated 90° counterclockwise along the clockwise direction of the second annular magnetic steel to become the magnetic field direction of the third magnetic tile, so that the quadrupole of the magnetic field in the inner diameter direction of the second annular magnetic steel is enhanced.

[0019] By adopting the above technical solution, the quadrupole of the magnetic field in the inner diameter direction of the second annular magnet is enhanced, so that the magnetic beads in the test tube can be separated at the quadrupole side wall of the test tube. The above method can improve the separation rate and separation effect of the magnetic beads in the test tube.

[0020] The third splicing method of the annular magnetic steel assembly is the third annular magnetic steel. The third annular magnetic steel includes twelve magnetic tiles of the same shape. The third annular magnetic steel is spliced ​​by twelve magnetic tiles. The magnetic field directions of the relatively arranged magnetic tiles are the same, and the magnetic field square of the first magnetic tile of the four adjacent magnetic tiles is rotated 360° clockwise along the clockwise direction of the third annular magnetic steel to become the magnetic field direction of the fourth magnetic tile, so that the inner diameter direction of the magnetic field of the third annular magnetic steel is enhanced.

[0021] By adopting the above technical solution, the six poles of the magnetic field in the inner diameter direction of the third annular magnet are enhanced, so that the magnetic beads in the test tube can be separated at the six-level side wall of the test tube. The above method can improve the separation rate and separation effect of the magnetic beads in the test tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic structural diagram of embodiment 1 of the present invention;

[0023] Figure 2 This is a schematic structural diagram of a first magnet assembly according to a first embodiment of the present invention;

[0024] Figure 3 Schematic diagram of the cross-sectional structure of embodiment 1 of the present invention;

[0025] Figure 4 This is a schematic structural diagram of a side panel according to a first embodiment of the present invention;

[0026] Figure 5 Schematic diagram of the structure of the strip magnetic steel assembly according to the first embodiment of the present invention;

[0027] Figure 6 This is a structural diagram of embodiment 2 of the present invention;

[0028] Figure 7 This is a schematic structural diagram of a bottom plate according to a second embodiment of the present invention;

[0029] Figure 8 This is a schematic structural diagram of the first annular magnetic steel according to the second embodiment of the present invention;

[0030] Figure 9 This is a structural schematic diagram of the magnetic field direction of the first annular magnetic steel and the magnetic field direction of each magnetic tile in embodiment 2 of the present invention;

[0031] Figure 10 This is a schematic structural diagram of the second annular magnetic steel according to the second embodiment of the present invention;

[0032] Figure 11 This is a structural schematic diagram of the magnetic field direction of the second annular magnetic steel and the magnetic field direction of each magnetic tile in embodiment 2 of the present invention;

[0033] Figure 12 Schematic diagram of the structure of the third annular magnetic steel according to the second embodiment of the present invention;

[0034] Figure 13 This is a structural schematic diagram of the magnetic field direction of the third annular magnetic steel and the magnetic field direction of each magnetic tile in the second embodiment of the present invention.

[0035] Figure: 1. Plastic bracket; 1.1. Bottom plate; 1.1.1. Positioning hole; 1.2. Top plate; 1.2.1. Test tube hole; 1.3. Side plate; 1.3.1. Groove; 2. First magnet assembly; 2.1. Bar magnet assembly; 2.1.1. First auxiliary magnet; 2.1.2. Second auxiliary magnet; 2.1.3. Third auxiliary magnet; 2.1.4. First magnetic core; 2.1.4.1. First magnetic crown; 2.1.4.2. First magnetic 2.1.4.3, second magnetic crown; 2.1.4.4, first arc surface; 2.1.5, second magnetic core; 2.1.5.1, third magnetic crown; 2.1.5.2, second magnetic base; 2.1.5.3, fourth magnetic crown; 2.1.5.4, second arc surface; 3. second magnet assembly; 3.1, annular magnetic steel assembly; 3.1.1, first annular magnetic steel; 3.1.2, second annular magnetic steel; 3.1.3, third annular magnetic steel; 4. test tube. DETAILED DESCRIPTION

[0036] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0037] Example 1:

[0038] See also Figure 1-5 As shown, in this embodiment: a nanomagnetic bead separator includes a test tube rack, the test tube rack includes a plastic rack 1 and a magnet assembly, the plastic rack 1 is provided with several rows of test tube holes 1.2.1, and the test tube holes 1.2.1 are inserted with test tubes 4 for accommodating magnetic beads. It is characterized in that: it also includes a magnet assembly for separating magnetic beads, the magnet assembly includes a plurality of magnetic steel assemblies, each magnetic steel assembly is arranged corresponding to the corresponding test tube 4, and the magnetic field of each magnetic steel assembly affects the corresponding test tube 4, so that the nanomagnetic beads are separated to the side wall of the test tube 4.

[0039] The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: the magnet assembly includes multiple magnetic steel assemblies, each magnetic steel assembly is arranged corresponding to the corresponding test tube 4, thereby enhancing the surface magnetic strength of the magnet assembly, thereby accelerating the separation rate of the nanomagnetic beads and improving the separation effect of the nanomagnetic beads.

[0040] The magnet assembly includes a first magnet assembly 2, which is arranged between two adjacent rows of test tube holes 1.2.1. The first magnet assembly 2 includes multiple bar magnet steel assemblies 2.1, each bar magnet steel assembly 2.1 corresponds to the test tube holes 1.2.1 in the same row, and the magnetic field of each bar magnet steel assembly 2.1 affects the adjacent test tubes 4 in the same row.

[0041] The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: by arranging the first magnet assembly 2 between two adjacent columns of test tube holes 1.2.1, the first magnet assembly 2 can simultaneously affect the two adjacent columns of test tubes 4, while ensuring that the effect of the test tubes 4 being affected by the magnetic field remains unchanged, while saving the space of the test tube rack, and improving the utilization rate of the first magnet assembly 2. The first magnet assembly 2 includes a plurality of bar magnetic steel assemblies 2.1, each bar magnetic steel assembly 2.1 corresponds to the test tube holes 1.2.1 in the same row, and two adjacent test tubes 4 in the same row share the same bar magnetic steel assembly, saving manufacturing costs, and also making the magnetic field of each bar magnetic steel assembly 2.1 affect the adjacent test tubes 4 in the same row separately, so that the nanomagnetic beads are separated to the inner wall of one side of the test tube 4, ensuring the separation rate and separation effect of the magnetic beads in each test tube 4.

[0042] The plastic bracket 1 includes a bottom plate 1.1, a top plate 1.2 arranged above the bottom plate 1.1, and two side plates 1.3 arranged between the bottom plate 1.1 and the top plate 1.2 for supporting the top plate 1.2. The two side plates 1.3 are arranged opposite to each other, a test tube hole 1.2.1 is arranged on the top plate 1.2, and a positioning hole 1.1.1 corresponding to the test tube hole 1.2.1 is provided on the bottom plate 1.1, and the positioning hole 1.1.1 and the test tube hole 1.2.1 are coaxially arranged.

[0043] The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: the test tube 4 is arranged in the positioning hole 1.1.1 through the test tube hole 1.2.1, and the test tube hole 1.2.1 is coaxially arranged with the positioning hole 1.1.1, so that the positioning hole 1.1.1 can better and more accurately fix the position of the test tube 4.

[0044] A groove 1.3.1 is provided on the side surface of the side plate 1.3, and two ends of the first magnet assembly 2 are respectively arranged in the groove 1.3.1 of the oppositely arranged side plate 1.3.

[0045] The technical solution in the above embodiment of the present application has at least the following technical effects or advantages: the opposite side panels 1.3 are provided with grooves 1.3.1, and the two ends of the first magnet assembly 2 are arranged in the grooves 1.3.1, which can limit the horizontal movement of the first magnet assembly 2.

[0046] The strip magnet assembly 2.1 includes a first auxiliary magnet 2.1.1, a first magnetic core 2.1.4, a second auxiliary magnet 2.1.2, a second magnetic core 2.1.5, and a third auxiliary magnet 2.1.3, which are arranged vertically and in sequence. The specific splicing method of the strip magnet assembly 2.1 is as follows: the magnetic poles of the first auxiliary magnet 2.1.1 and the third auxiliary magnet 2.1.3 are in the same direction, and the magnetic poles of the first auxiliary magnet 2.1.1 and the third auxiliary magnet 2.1.3 are parallel to the central axis of the strip magnet assembly 2.1. The magnetic pole direction of the second auxiliary magnet 2.1.2 is opposite to the magnetic pole direction of the first auxiliary magnet 2.1.1; the first magnetic core 2.1.4 includes a first magnetic crown 2.1.4.1 at the upper end, a first magnetic base 2.1.4.2 at the middle end, and a second magnetic crown 2.1.4.3 at the lower end. The first magnetic crown 2.1.4.1 and the second magnetic crown 2.1 are connected to each other. .4.3 are arranged with their magnetic poles facing each other and perpendicular to the central axis. The first magnetic base 2.1.4.2 includes two vertically arranged parts, and the magnetic field directions of the two parts of the first magnetic base 2.1.4.2 are arranged in opposite directions, and the magnetic field directions of the two parts of the first magnetic base 2.1.4.2 are perpendicular to the magnetic field direction of the first auxiliary magnet 2.1.1. The second magnetic core 2.1.5 includes a third magnetic crown 2.1.5.1 arranged at the upper end, a second magnetic base 2.1.5.2 arranged at the middle end, and a fourth magnetic crown 2.1.5.3 arranged at the lower end. The magnetic pole directions of the third magnetic crown 2.1.5.1 and the fourth magnetic crown 2.1.5.3 are arranged in opposite directions. The second magnetic base 2.1.5.2 includes two vertically arranged parts, and the magnetic field directions of the two parts of the second magnetic base 2.1.5.2 are arranged in opposite directions, and the magnetic field directions of the two parts of the second magnetic base 2.1.5.2 are perpendicular to the magnetic field direction of the first auxiliary magnet 2.1.1.

[0047] The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: the magnetic field directions of the two parts of the first magnetic base 2.1.4.2 are arranged in back-to-back directions, the magnetic field directions of the two parts of the second magnetic base 2.1.5.2 are arranged opposite to each other, and the remaining magnets are shared, which saves space and manufacturing costs. By setting the angle of the magnetic field direction of each magnet in the bar magnet assembly 2.1, the magnetic field is enhanced at the connection between the adjacent test tubes 4 on both sides. The enhanced magnetic field can realize rapid and efficient separation of the nanomagnetic beads, so that the nanomagnetic beads are separated to the inner wall of one side of the test tube 4.

[0048] The positions of the first magnetic core 2.1.4 and the second magnetic core 2.1.5 correspond to the positions of the test tube 4. A first arc surface 2.1.4.4 is provided at the connection between the first magnetic core 2.1.4 and the test tube 4, and a second arc surface 2.1.5.4 is provided at the connection between the second magnetic core 2.1.5 and the test tube 4. The first arc surface 2.1.4.4 and the second arc surface 2.1.5.4 cooperate with the test tube 4.

[0049] The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: a first arc surface 2.1.4.4 is provided at the connection between the first magnetic core 2.1.4 and the test tube 4, and a second arc surface 2.1.5.4 is provided at the connection between the second magnetic core 2.1.5 and the test tube 4, which can make the first magnetic core 2.1.4 and the second magnetic core 2.1.5 better fit the outer wall, thereby improving the efficiency of the separator in separating the nanomagnetic beads.

[0050] Example 2:

[0051] See also Figure 6-13 As shown, in this embodiment: a nanomagnetic bead separator includes a test tube rack, the test tube rack includes a plastic rack 1 and a second magnet assembly 3, the plastic rack 1 is provided with several rows of test tube holes 1.2.1, and test tubes 4 are inserted into the test tube holes 1.2.1. The second magnet assembly 3 includes several annular magnetic steel assemblies 3.1, the annular magnetic steel assemblies 3.1 are arranged on the plastic rack 1 and below the test tube holes 1.2.1, each annular magnetic steel assembly 3.1 corresponds to each test tube hole 1.2.1 and is coaxially arranged, the test tube 4 is inserted into the central axis of the annular magnetic steel assembly 3.1 through the test tube hole 1.2.1, and the magnetic field of each annular magnetic steel assembly 3.1 affects the corresponding test tube 4.

[0052] The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: the test tube 4 is inserted into the central axis of the annular magnetic steel assembly 3.1 through the test tube hole 1.2.1, and each annular magnetic steel assembly 3.1 affects one test tube 4, so that the magnetic field effect of the annular magnetic steel assembly 3.1 is enhanced on the test tube 4, thereby improving the separation efficiency of the nanomagnetic beads.

[0053] The plastic bracket 1 includes a bottom plate 1.1, a top plate 1.2 arranged above the bottom plate 1.1, and two side plates 1.3 arranged between the bottom plate 1.1 and the top plate 1.2 for supporting the top plate 1.2. The two side plates 1.3 are arranged opposite to each other, a test tube hole 1.2.1 is arranged on the top plate 1.2, and a positioning hole 1.1.1 corresponding to the test tube hole 1.2.1 is provided on the bottom plate 1.1, and the positioning hole 1.1.1 and the test tube hole 1.2.1 are coaxially arranged.

[0054] The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: the test tube 4 is arranged in the positioning hole 1.1.1 through the test tube hole 1.2.1, and the test tube hole 1.2.1 is coaxially arranged with the positioning hole 1.1.1, so that the positioning hole 1.1.1 can better and more accurately fix the position of the test tube 4.

[0055] The annular magnetic steel assembly 3.1 includes a plurality of magnetic tiles, which are in the shape of strips, and the annular magnetic steel assembly 3.1 is spliced ​​by the magnetic tiles. There are three splicing methods of the annular magnetic steel assembly 3.1: the first splicing method of the annular magnetic steel assembly 3.1 is the first annular magnetic steel 3.1.1, which includes twelve magnetic tiles of the same shape. The first annular magnetic steel 3.1.1 is spliced ​​by twelve magnetic tiles, and the magnetic fields of the relatively arranged magnetic tiles have the same direction. The magnetic field direction of the first magnetic tile of the four adjacent magnetic tiles is rotated 180° clockwise along the clockwise direction of the first annular magnetic steel 3.1.1 to become the magnetic field direction of the fourth magnetic tile, so that the inner diameter direction of the magnetic field of the first annular magnetic steel 3.1.1 is enhanced at both poles; the second splicing method of the annular magnetic steel assembly 3.1 is the second annular magnetic steel 3.1.2, which includes eight magnetic tiles of the same shape. The annular magnet 3.1.2 is composed of eight magnetic tiles. The magnetic field directions of the relatively arranged magnetic tiles are opposite, and the magnetic field direction of the first magnetic tile of the three adjacent magnetic tiles is rotated 90° counterclockwise along the clockwise direction of the second annular magnet 3.1.2 to become the magnetic field direction of the third magnetic tile, so that the quadrupole of the magnetic field in the inner diameter direction of the second annular magnet 3.1.2 is enhanced; the third splicing method of the annular magnet assembly 3.1 is the third annular magnet 3.1.3. The third annular magnet 3.1.3 includes twelve magnetic tiles of the same shape. The third annular magnet 3.1.3 is composed of twelve magnetic tiles. The magnetic field directions of the relatively arranged magnetic tiles are the same, and the magnetic field square of the first magnetic tile of the four adjacent magnetic tiles is rotated 360° clockwise along the clockwise direction of the third annular magnet 3.1.3 to become the magnetic field direction of the fourth magnetic tile, so that the sextupole of the magnetic field in the inner diameter direction of the third annular magnet 3.1.3 is enhanced.

[0056] The technical solutions in the above-mentioned embodiments of the present application have at least the following technical effects or advantages: the two poles of the magnetic field in the inner diameter direction of the first annular magnet 3.1.1 are enhanced, so that the magnetic beads in the test tube 4 can be separated at the two pole side walls of the test tube 4; the four poles of the magnetic field in the inner diameter direction of the second annular magnet 3.1.2 are enhanced, so that the magnetic beads in the test tube 4 can be separated at the four pole side walls of the test tube 4; the six poles of the magnetic field in the inner diameter direction of the third annular magnet 3.1.3 are enhanced, so that the magnetic beads in the test tube 4 can be separated at the six pole side walls of the test tube 4. The above methods can improve the separation rate and separation effect of the magnetic beads in the test tube 4.

[0057] The above description is merely a description of the preferred embodiment of the present invention and is not to be construed as limiting the scope of the claims. The present invention is not limited to the above embodiment, and variations in the specific structure are permitted. Any variations within the scope of the independent claims of the present invention are also within the scope of protection of the present invention.

Claims

1. A nanomagnetic bead separator, comprising a test tube rack, the test tube rack comprising a plastic rack (1) and a magnet assembly, the plastic rack (1) being provided with a plurality of test tube holes (1.2.1), the test tube holes (1.2.1) being inserted with test tubes (4) for accommodating magnetic beads, characterized in that: It also includes a magnet assembly for separating magnetic beads, the magnet assembly including a plurality of magnetic steel assemblies, each magnetic steel assembly being arranged corresponding to a corresponding test tube (4), and the magnetic field of each magnetic steel assembly having an influence on the corresponding test tube (4) so ​​that the nanomagnetic beads are separated to the side wall of the test tube (4); The magnet assembly includes a first magnet assembly (2), the first magnet assembly (2) is arranged between two adjacent rows of test tube holes (1.2.1), the first magnet assembly (2) includes a plurality of bar-shaped magnetic steel assemblies (2.1), each of the bar-shaped magnetic steel assemblies (2.1) corresponds to the test tube holes (1.2.1) in the same row, and the magnetic field of each bar-shaped magnetic steel assembly (2.1) affects the adjacent test tubes (4) in the same row; The strip magnetic steel assembly (2.1) comprises first auxiliary magnetic steels ( 2.1.1), the first magnetic core (2.1.4), the second auxiliary magnetic steel (2.1.2), the second magnetic core (2.1.5) and the third auxiliary magnetic steel ( 2.1.3), the specific splicing method of the strip magnetic steel assembly (2.1) is as follows: The magnetic pole directions of the first auxiliary magnetic steel (2.1.1) and the third auxiliary magnetic steel (2.1.3) are the same, and the magnetic pole directions of the first auxiliary magnetic steel (2.1.1) and the third auxiliary magnetic steel (2.1.3) are parallel to the central axis of the bar magnetic steel assembly (2.1), and the magnetic pole direction of the second auxiliary magnetic steel (2.1.2) is opposite to the magnetic pole direction of the first auxiliary magnetic steel (2.1.1); The first magnetic core (2.1.4) includes a first magnetic crown (2.1.4.1) provided at the upper end, a first magnetic base (2.1.4.2) provided at the middle end, and a second magnetic crown (2.1.4.3) provided at the lower end. The magnetic poles of the first magnetic crown (2.1.4.1) and the second magnetic crown (2.1.4.3) are arranged in opposite directions and perpendicular to the central axis. The first magnetic base (2.1.4.2) includes two vertically arranged parts, and the magnetic field directions of the two parts of the first magnetic base (2.1.4.2) are arranged in opposite directions, and the magnetic field directions of the two parts of the first magnetic base (2.1.4.2) are perpendicular to the magnetic field direction of the first auxiliary magnetic steel (2.1.1); The second magnetic core (2.1.5) includes a third magnetic crown (2.1.5.1) provided at the upper end, a second magnetic base (2.1.5.2) provided at the middle end, and a fourth magnetic crown (2.1.5.3) provided at the lower end. The magnetic poles of the third magnetic crown (2.1.5.1) and the fourth magnetic crown (2.1.5.3) are arranged in opposite directions and perpendicular to the central axis. The second magnetic base (2.1.5.2) includes two vertically arranged parts, and the magnetic field directions of the two parts of the second magnetic base (2.1.5.2) are arranged opposite to each other, and the magnetic field directions of the two parts of the second magnetic base (2.1.5.2) are perpendicular to the magnetic field direction of the first auxiliary magnet (2.1.1).

2. A nanomagnetic bead separator according to claim 1, characterized in that: The positions of the first magnetic core (2.1.4) and the second magnetic core (2.1.5) correspond to the positions of the test tube (4). A first arc surface (2.1.4.4) is provided at the connection between the first magnetic core (2.1.4) and the test tube (4). A second arc surface (2.1.5.4) is provided at the connection between the second magnetic core (2.1.5) and the test tube (4). The first arc surface (2.1.4.4) and the second arc surface (2.1.5.4) cooperate with the test tube (4).

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