Electrical stimulator

Abstract

The application discloses a communication method of an electric stimulator and the electric stimulator, the electric stimulator comprises an implantable power supply unit, a first chip and a second chip, the first chip and the second chip are electrically connected with the implantable power supply unit through a plurality of wires, the first chip is connected with a first sub-electrode, and the second chip is connected with a second sub-electrode; the communication method comprises the following steps: the implantable power supply unit sends a command to the first chip or the second chip, the command comprises an address identification code, so as to determine the chip responding to the command; in the same period, only one of the first chip and the second chip responds to the command. According to the communication method of the electric stimulator, the same implantable power supply unit can realize signal transmission between the first sub-electrode or the second sub-electrode, the communication mode is simple and efficient, and is especially suitable for high-density electrodes, and the stimulation precision is higher.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of implantable medical devices, in particular to an electrical stimulator. BACKGROUND

[0002] Deep brain stimulator (DBS) can effectively treat movement disorder diseases, and can also be used for the treatment of mental diseases, such as Parkinson's disease, epilepsy, depression, addictive diseases, etc.

[0003] The electrode of the deep brain stimulator is an important component of the deep brain stimulator, and the electrode is generally electrically connected with the implantable power supply unit through a lead wire. However, for high-density DBS electrodes, the number of stimulation sites on the electrode stimulation end (electrode part) is generally more than the number of lead wires. How to realize the communication between the implantable power supply unit and the electrode stimulation end is a difficult problem to be solved by those skilled in the art. SUMMARY

[0004] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, one object of the present application is to provide an electrical stimulator, and the signal transmission between the implantable power supply unit and the first sub-electrode or the second sub-electrode is simple and efficient.

[0005] According to the electrical stimulator of the embodiment of the present application, the electrical stimulator comprises an implantable power supply unit, a first chip and a second chip, the first chip and the second chip are electrically connected with the implantable power supply unit through a plurality of lead wires, the first chip is connected with a first sub-electrode, and the second chip is connected with a second sub-electrode; the lead wire connects the first chip and the second chip through a connector, the connector is provided with a wire arrangement groove suitable for embedding the lead wire and a conductive pin extending in the thickness direction, and the conductive pin simultaneously connects the first chip located above and the second chip located below;

[0006] The communication method of the electrical stimulator comprises the following steps:

[0007] The implantable power supply unit sends a command to the first chip or the second chip, and the command comprises an address identification code to determine the chip responding to the command;

[0008] In the same period, only one of the first chip and the second chip responds to the command.

[0009] The electric stimulator according to the embodiment of the present application can quickly distinguish the first chip and the second chip responding to the command, thereby facilitating the communication between the implantable power supply unit and the first sub-electrode and the second sub-electrode. In addition, the command of the same implantable power supply unit can be accurately transmitted to the corresponding first sub-electrode or second sub-electrode, and the communication mode of the present application is simple and efficient, and is particularly suitable for high-density electrodes and has high stimulation accuracy.

[0010] According to some embodiments of the present application, the communication mode between the implantable power supply unit and the first chip and the second chip is serial communication.

[0011] According to some embodiments of the present application, the communication protocol between the implantable power supply unit and the first chip and the second chip is I 2 C, SMBus, RS232 or RS485.

[0012] According to some embodiments of the present application, the communication method comprises:

[0013] The implantable power supply unit sends a command to the first chip and the second chip to form a signal downward;

[0014] In the same period, only one of the first chip or the second chip responds to the command to form a signal upward;

[0015] A level converter is added on the path of the signal upward and the path of the signal downward, respectively.

[0016] According to some embodiments of the present application, the lead wire comprises at least four lead wires, and the at least four lead wires comprise two power supply lines and two data lines.

[0017] According to some embodiments of the present application, the voltage on the data line is symmetrical alternating current.

[0018] According to some embodiments of the present application, the first sub-electrode and the second sub-electrode are curled and attached to the electrode support column to form an electrode part.

[0019] According to some embodiments of the present application, the electric stimulator is specifically a deep brain electric stimulator.

[0020] Additional aspects and advantages of the present application will be in part apparent and in part pointed out hereinafter. BRIEF DESCRIPTION OF DRAWINGS

[0021] The above and / or additional aspects and advantages of the present application will become apparent and be readily understood from the following description, taken in conjunction with the accompanying drawings, in which:

[0022] Figure 1is a schematic view of an electrode structure according to an embodiment of the present application;

[0023] Figure 2 is an exploded view of an electrode structure according to an embodiment of the present application;

[0024] Figure 3 is Figure 2 is a magnified view of the D area shown in the circle;

[0025] Figure 4 is Figure 2 is a magnified view of the E area shown in the circle;

[0026] Figure 5 is Figure 2 is a magnified view of the F area shown in the circle;

[0027] Figure 6 is a schematic view of a connector according to an embodiment of the present application;

[0028] Figure 7 is a schematic view of a connector according to an embodiment of the present application from another angle;

[0029] Figure 8 is a top view of an electrode structure according to an embodiment of the present application;

[0030] Figure 9 is Figure 8 is a schematic view of the G area shown in the circle;

[0031] Figure 10 is a schematic view of an electrode structure according to an embodiment of the present application from another angle;

[0032] Figure 11 is Figure 10 is a schematic view of the H area shown in the circle;

[0033] Figure 12 is a flowchart of a communication method of an electrical stimulator according to an embodiment of the present application;

[0034] Figure 13 is a flowchart of signal transmission of a communication method of an electrical stimulator according to an embodiment of the present application.

[0035] Reference Signs:

[0036] 100, electrode structure;

[0037] 200, connector;

[0038] 201, first section; 2012, guide pin positioning hole;

[0039] 202, second section; 2021, step structure; 2023, through hole; 205, guide pin;

[0040] 1a, electrode part; 1, electrode support column; 11, first sub support section;

[0041] 12, second sub support section; 121, positioning hole;

[0042] 13, groove; 14, limiting hole;

[0043] 21, first sub electrode; 22, second sub electrode;

[0044] 23, connecting cable; 24, folded edge; 3, glue injection part;

[0045] 4, sleeve; 5, wire;

[0046] 6, first chip; 7, second chip;

[0047] 81, wire arranging groove; 82, conductive pin. DETAILED DESCRIPTION

[0048] The embodiments of the present application are described in detail below, the embodiments described with reference to the accompanying drawings are exemplary, and the following description is made with reference to Figures 1-11 An electrical stimulator according to an embodiment of the present application is described.

[0049] The electrical stimulator (not shown in the figure) comprises an implantable power supply unit (not shown in the figure), a first chip 6 and a second chip 7, the first chip 6 and the second chip 7 are electrically connected with the implantable power supply unit through a plurality of wires 5, the first chip 6 is connected with a first sub electrode 21, and the second chip 7 is connected with a second sub electrode 22. For example, the first sub electrode 21 and the second sub electrode 22 are high-density flexible electrodes 2, and a plurality of stimulation sites (not shown in the figure) are arranged on the first sub electrode 21 and the second sub electrode 22. In the description of the present application, the meaning of “a plurality of” is two or more. The first chip 6 and the second chip 7 can be ASIC (Application Specific Integrated Circuit) chips. A plurality of stimulation sites, tens, hundreds or even more, are preferably arranged on the first sub electrode 21 and the second sub electrode 22, so as to form a flexible electrode with higher density compared with the prior art. The first sub electrode 21 and the second sub electrode 22 are preferably manufactured into a strip-shaped structure through a MEMS process, and finally form a required electrode size (such as a standard DBS electrode size). In addition, the implantable power supply unit can be provided with a power supply, or an external part can be used and powered through a wireless radio frequency mode, and can be used as a master control device.

[0050] Thus, the plurality of stimulation sites of the first sub electrode 21 and the second sub electrode 22 can communicate with the implantable power supply unit through the first chip 6, the second chip 7 and the wires 5. The above stimulation sites can also be used as recording sites, and in addition, recording sites can be additionally arranged on each sub electrode, which are all encompassed in the technical solutions of the present application.

[0051] In addition, compared with the traditional electrode structure 100, the first sub-electrode 21 and the second sub-electrode 22 have more stimulation sites and smaller contact areas, and it is not easy to stimulate unnecessary areas, so as to reduce the side effects of using the electrical stimulator. In addition, by using the flexible electrode 2, directional stimulation, partition stimulation and multi-target point stimulation can be realized, so as to greatly improve the stimulation accuracy of the electrical stimulator, reduce the dependence on the implantation accuracy of the electrode, reduce the complications caused by the electrical stimulation, and thus ensure the treatment effect and realize precise treatment. For example, in cooperation with the recording electrode, the brain nerve activity signal can be accurately collected, and objective parameters can be provided for clinicians, so as to realize personalized closed-loop control treatment.

[0052] As shown in Figure 1 、 Figure 2 and Figure 12 , the communication method of the electrical stimulator according to the first aspect of the present application comprises the following steps:

[0053] The implantable power supply unit sends a command to the first chip 6 or the second chip 7, and the command includes an address identification code to determine the chip that responds to the command;

[0054] In the same period, only one of the first chip 6 and the second chip 7 responds to the command.

[0055] Therefore, by means of the address identification code, the first chip 6 and the second chip 7 that respond to the command can be distinguished, so as to facilitate the communication between the implantable power supply unit and the first sub-electrode 21 and the second sub-electrode 22. In addition, by making one of the first chip 6 and the second chip 7 respond to the command, the command of the implantable power supply unit can be accurately transmitted to the corresponding first sub-electrode 21 or second sub-electrode 22, thereby improving the accuracy of signal transmission of the electrical stimulator and improving the stimulation accuracy of the electrical stimulator.

[0056] The electrical stimulator according to the embodiment of the present application can accurately transmit the command of the same implantable power supply unit to the corresponding first sub-electrode 21 or second sub-electrode 22, and the communication method is simple and efficient, and is especially suitable for high-density electrodes and has high stimulation accuracy.

[0057] According to some embodiments of the present application, the communication method between the implantable power supply unit and the first chip 6 and the second chip 7 is serial communication. Therefore, it is beneficial to the signal transmission between the implantable power supply unit and the first chip 6 and the second chip 7, and the transmission line is less, so as to make the size of the electrical stimulator smaller, the assembly process simple and the cost low.

[0058] Optionally, the communication protocol between the implantable power supply unit and the first chip 6 and the second chip 7 is I 2C, SMBus, RS232 or RS485, etc. Thus, by using the above communication protocol, it is beneficial for the signal transmission between the implantable power supply unit and the first chip 6 and the second chip 7, and it is beneficial for the normal use of the electrical stimulator.

[0059] According to some embodiments of the present application, in combination Figure 13 , the implantable power supply unit sends a command to the first chip 6 or the second chip 7, forming a signal downward;

[0060] In the same period, only one of the first chip 6 and the second chip 7 responds to the command, forming a signal upward;

[0061] A level converter is added to the signal upward path and the signal downward path, respectively.

[0062] When the electrical stimulator is implanted in human tissue, after the first chip 6 or the second chip 7 receives the command from the implantable power supply unit, the command is output to the first sub-electrode 21 or the second sub-electrode 22, so that the implantable power supply unit can send directional electrical stimulation to the corresponding functional area, achieving the effect of precise treatment. In addition, by adding a level converter to the signal upward path and the signal downward path, respectively, the level conversion of the signal is realized, which is convenient for system development and can be used for movement disorders such as Parkinson's disease, dystonia, tremor, and frozen gait. In addition, it can also be used as a replacement treatment for drug addiction and depression.

[0063] Optionally, the lead 5 includes at least four leads, including two power lines and two data lines. In this way, the data lines can be used for the transmission of command signals, and the power lines can be used for the transmission of energy signals, thereby ensuring the normal use of the lead 5, while the number of leads is small, which can reduce the size of the lead 5. The power lines of the embodiment of the present application exist in the form of symmetrical alternating current.

[0064] According to some embodiments of the present application, the voltage on the data line is symmetrical alternating current. Thus, the signal transmission is more stable, which is beneficial for the signal transmission of the data line, while reducing the risk of direct current leakage and improving safety.

[0065] According to the electrical stimulator of the embodiment of the present application, by using the above communication method of the electrical stimulator, the command of the implantable power supply unit, such as electrical stimulation, can be quickly and accurately transmitted to the first electrode or the second electrode, and the signal feedback of the first chip 6 or the second chip 7 can also be received in time, thereby realizing the effective connection between the electrode structure 100 and the implantable power supply unit, and ensuring the stimulation waveform control of a single electrode, thereby improving the accurate control of the stimulation direction and realizing a better stimulation effect.

[0066] According to some embodiments of the present application, in combination Figure 2 , Figure 6 andFigure 7 The lead wire 5 connects the first chip 6 and the second chip 7 through the connector 200, the connector 200 is provided with a wire slot 81 suitable for embedding the lead wire 5 and a conductive pin 82 extending along the thickness direction, the conductive pin 82 connects the first chip 6 above and the second chip 7 below at the same time.

[0067] For example, in the example of Figure 6 and Figure 7 , the upper surface and the lower surface of the connector 200 are both formed with the wire slot 81. Thus, the wire slot 81 has a supporting and fixing effect on the lead wire 5, thereby facilitating the connection of the lead wire 5 with the first chip 6 and the second chip 7, and the connection is stable. In addition, the first chip 6 of the electrical stimulator is located above the connector 200, and the second chip 7 of the electrical stimulator is located below the connector 200, and the first chip 6 and the second chip 7 can be electrically connected through the conductive pin 82.

[0068] According to some embodiments of the present application, the first sub-electrode 21 and the second sub-electrode 22 are curled and attached to the electrode support column 1 to form an electrode part. The structures of the first sub-electrode 21 and the second sub-electrode 22 are substantially the same, both of which are curled and attached to the outer circumferential side of the electrode support column 1 along the circumferential direction of the electrode support column 1, and the long edges of the first sub-electrode 21 and the second sub-electrode 22 are arranged along the axial direction of the electrode support column 1. For example, in the example of Figure 2 , the first sub-electrode 21, the second sub-electrode 22 and the electrode support column 1 all extend along the axial direction (i.e. the left-right direction, for example, the direction indicated by the arrow A in Figure 2 ), and the first sub-electrode 21 and the second sub-electrode 22 are arranged along the circumferential direction of the electrode support column 11. In this way, the electrode support column 1 has a supporting effect on the first sub-electrode 21 and the second sub-electrode 22. In addition, the structures of the first sub-electrode 21 and the second sub-electrode 22 are simple, and the production difficulty is relatively small, which facilitates the production and processing of the first sub-electrode 21 and the second sub-electrode 22, and is conducive to the assembly of the electrode part.

[0069] According to some embodiments of the present application, the electrical stimulator can be a deep brain electrical stimulator (not shown in the figure), and can also be a spinal cord stimulator or other possible electrical stimulator.

[0070] Referring to Figure 2 , the first sub-electrode 21 and the second sub-electrode 22 are both provided with a connection cable 23 connected to a plurality of stimulation sites, and the connection cable 23 is suitable for electrical connection with an implantable power supply unit of the electrical stimulator. Specifically, one end of the connection cable 23 is electrically connected to the plurality of stimulation sites, and the other end of the connection cable 23 is electrically connected to the implantable power supply unit. Thus, the plurality of stimulation sites of the first sub-electrode 21 and the second sub-electrode 22 can be electrically connected to the implantable power supply unit through the connection cable 23, which is conducive to the signal transmission between the implantable power supply unit and the flexible electrode.

[0071] According to some embodiments of the present application, referring to Figure 2 , the electrode support column 1 comprises a first sub-support section 11 and a second sub-support section 12 fixedly connected with each other, for example, the first sub-support section 11 and the second sub-support section 12 can have substantially the same structure. The first sub-electrode 21 is fixed on the first sub-support section 11, and the second sub-electrode 22 is fixed on the second sub-support section 12. In this way, the use stability of the first sub-electrode 21 and the second sub-electrode 22 is improved. In addition, the first sub-support section 11 and the second sub-support section 12 have simple structure and are convenient to produce and process.

[0072] Optionally, referring to Figures 2-4 , at least one positioning hole 121 is formed on the first sub-support section 11 and the second sub-support section 12, and the electrode structure 100 further comprises at least one positioning member (for example, a pin), which is fitted into the positioning hole 121 on the first sub-support section 11 and the second sub-support section 12 to connect the first sub-support section 11 and the second sub-support section 12 into one body. In this way, the assembly operation between the first sub-support section 11 and the second sub-support section 12 is simple, the connection is firm, and the service life is long.

[0073] Further, in combination with Figures 2-4 , a groove 13 is formed on the first sub-support section 11 and the second sub-support section 12, and the long sides of the first sub-electrode 21 and the second sub-electrode 22 (for example, Figure 2 the direction indicated by arrow B in the figure) are respectively provided with a folded edge 24, which is fixed in the corresponding groove 13. In this way, the assembly of the first sub-electrode 21 and the first sub-support section 11, and the second sub-electrode 22 and the second sub-support section 12 is facilitated, and the assembly is reliable, which is conducive to the long-term stable use of the first sub-electrode 21 and the second sub-electrode 22. Moreover, the side wall of the groove 13 has a limiting effect on the folded edge 24, further improving the connection stability of the first sub-electrode 21, the second sub-electrode 22 and the electrode support column 1.

[0074] According to some embodiments of the present application, referring to Figure 2 and Figure 3 , a limiting hole 14 is arranged at the end of the electrode support column 1, and the electrode structure 100 further comprises a glue injection member 3, the end of the electrode support column 1 and the corresponding end of the first sub-electrode 21 and the second sub-electrode 22 are fixedly connected through the glue injection member 3, and a part of the glue injection member 3 is filled in the limiting hole 14. In this way, the glue injection member 3 can realize reliable fixation of the first sub-electrode 21 and the second sub-electrode 22 to the electrode support column 1.

[0075] Optionally, in combination with Figure 2 and Figure 3The cross-sectional area of the limiting hole 14 gradually increases in the direction away from the glue injection part 3 along the axial direction of the electrode support column 1. Thus, the part of the glue injection part 3 filled in the limiting hole 14 is not easy to fall out of the limiting hole 14.

[0076] According to some embodiments of the present application, the electrode part 1a further comprises a third sub-electrode (not shown in the figure) in a strip structure, the first sub-electrode 21, the second sub-electrode 22 and the third sub-electrode are curled and attached to the outer circumferential side of the electrode support column 1. For example, the first sub-electrode 21, the second sub-electrode 22 and the third sub-electrode are arranged along the outer periphery of the electrode support column 1. It should be noted that the first sub-electrode 21 and the second sub-electrode 22 can be provided with multiple sub-electrodes according to the use requirements, so as to better meet the actual application.

[0077] Further, referring to Figure 2 , the electrode structure 100 comprises a sleeve 4 sleeved outside the connecting cable 23, and a plurality of wires 5 integrated in the sleeve 4. In this way, the connection stability between the components can be improved.

[0078] Optionally, in combination with Figure 2 , the plurality of wires 5 extend spirally and tightly along the axial direction of the sleeve 4. Thus, the space occupied by the wires 5 inside the sleeve 4 is saved, so that the electrode structure 100 is made more compact.

[0079] For example, Figure 2 five wires 5 are shown, which can be clock leads, interrupt leads, data leads, power leads and ground leads respectively, so as to meet the normal use of the electrode structure 100.

[0080] Further, as shown in Figure 5 , Figure 6 , Figure 7 and Figure 11 , the connector 200 comprises a first section 201 and a second section 202 arranged in the axial direction (for example, the direction indicated by the arrow A in Figure 2 ), a step structure 2021 is formed between the first section 201 and the second section 202, the thickness of the first section 201 is greater than that of the second section 202, a wire slot 81 is formed on the first section 201, and a conductive pin 82 is arranged on the second section 202.

[0081] For example, in the examples of Figure 6 and Figure 7 , the upper surface and the lower surface of the first section 201 are both formed with the wire slot 81, and one end of each of the plurality of wires 5 can be inserted into the plurality of wire slots 81 respectively. Moreover, the plurality of wires 5 can be electrically connected to the first chip 6 and the second chip 7 through the conductive pin 82 of the connector 200, which is convenient for connection.

[0082] According to some embodiments of the present application, referring toFigures 6-9 The wire arrangement groove 81 extends to the second section 202, and the width of the end of the wire arrangement groove 81 adjacent to the conductive pin 82 is greater than the width of other parts of the wire arrangement groove 81. The part with greater width facilitates the bending of the end of the wire 5, and the end of the wire 5 can be located between the conductive pin 82 and the side wall of the wire arrangement groove 81, which facilitates assembly and positioning and ensures the stability of the connection.

[0083] Optionally, in combination with Figure 2 , Figures 5-7 A plurality of through holes 2023 are arranged on the second section 202, and the plurality of conductive pins 82 are separately arranged and inserted into the through holes 2023. For example, the through holes 2023 can penetrate the second section 202 along the thickness direction and communicate with the wire arrangement groove 81. In this way, the installation and fixation of the conductive pins 82 are facilitated.

[0084] According to some embodiments of the present application, referring to Figure 6 , Figure 10 and Figure 11 , the end of the first section 201 away from the second section 202 is formed with a needle positioning hole 2012. For example, in the examples of Figure 6 and Figure 11 , the needle positioning hole 2012 extends along the central axis of the first section 201. When the implantation operation is performed, the needle 205 can extend into the needle positioning hole 2012 from the end of the first section 201 away from the second section 202, and then the electrode structure 100 can be smoothly pushed to the implantation position.

[0085] Further, two wire arrangement grooves 81 or three wire arrangement grooves 81 are arranged on the upper side surface of the first section 201, and the remaining wire arrangement grooves 81 are arranged on the lower side surface of the first section 201, but are not limited to this. For example, in the examples of Figure 2 , Figure 6 and Figure 7 , two wire arrangement grooves 81 are formed on the upper side surface of the first section 201, and the two wire arrangement grooves 81 are arranged at intervals along the width direction of the connector 200 (for example, the direction indicated by arrow B in Figure 2 , and three wire arrangement grooves 81 are formed on the lower side surface of the first section 201. In this way, the layout of the plurality of wire arrangement grooves 81 on the connector 200 is reasonable, which is conducive to the connection of the five wires 5 and the corresponding conductive pins 82.

[0086] The deep brain stimulator according to the embodiments of the present application and other configurations and operations of the electrode structure 100 are known to those skilled in the art, and will not be described in detail here.

[0087] In the description of the application, it should be understood that the terms "length", "width", "thickness", "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplification of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the application.

[0088] Although embodiments of the application have been shown and described, it will be understood by those having ordinary skill in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and the spirit of the application, the scope of which is defined by the claims and their equivalents.

Claims

1. An electrical stimulator, characterized in that The electrical stimulator includes an implantable power supply unit, a first chip, and a second chip, wherein the first chip and the second chip are electrically connected to the implantable power supply unit via a plurality of wires, the first chip is connected to the first sub-electrode, and the second chip is connected to the second sub-electrode; The wires connect the first chip and the second chip through a connector. The connector is provided with a wire management groove suitable for embedding the wires and a conductive pin extending along the thickness direction. The conductive pins simultaneously connect the first chip located above it and the second chip located below it. The communication method of the electrical stimulator comprises the following steps: The implantable power supply unit sends a command to the first chip or the second chip, wherein the command includes an address identification code to determine the chip that responds to the command; In the same time period, only one of the first chip and the second chip responds to the command.

2. The electrical stimulator according to claim 1, wherein The communication mode between the implantable power supply unit and the first chip and the second chip is serial communication.

3. The electrical stimulator according to claim 1, wherein The communication protocol between the implantable power supply unit and the first chip and the second chip is I 2 C, SMBus, RS232 or RS485.

4. The electrical stimulator according to claim 1, wherein include: The implantable power supply unit sends a command to the first chip or the second chip to form a signal downlink; In the same time period, only one of the first chip and the second chip responds to the command, forming an uplink signal; Level converters are added to the signal uplink path and the signal downlink path respectively.

5. The electrical stimulator according to any one of claims 1 to 4, characterized in that The conductive wires include at least four lead wires, and the at least four lead wires include two power lines and two data lines.

6. The electrical stimulator according to claim 5, characterized in that The voltage on the data line is a symmetrical alternating current.

7. The electrical stimulator according to claim 1, characterized in that The first sub-electrode and the second sub-electrode are rolled and attached to the electrode support column to form an electrode portion.

8. The electrical stimulator according to claim 1, wherein The electrical stimulator is a deep brain stimulator.

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