Blood pressure measurement device and method

Abstract

The embodiment of the specification provides a blood pressure measuring device and method. The device comprises an ultrasonic sensing module, a pressure sensing module, a light signal sensing module, a memory and a processing circuit; the ultrasonic sensing module is used for emitting an ultrasonic signal and receiving an ultrasonic signal reflected by a detection area, and generating a corresponding ultrasonic electrical signal; the pressure sensing module is used for generating a pressure signal; the light signal sensing module is used for emitting a light signal and receiving a light signal reflected by the detection area and generating a corresponding photoelectric signal; the memory is used for storing a blood pressure comparison model; the blood pressure comparison model is constructed according to a plurality of comparison blood pressure values calculated according to a plurality of ultrasonic electrical signals and a plurality of pressure signals and a plurality of comparison photoelectric signals; and the processing circuit is used for calculating a target user blood pressure value according to the blood pressure comparison model and the photoelectric signal. The above device ensures the accuracy of blood pressure measurement, simplifies the blood pressure measurement result and improves the user experience.

Description

TECHNICAL FIELD

[0001] Embodiments of the present specification relate to the technical field of blood pressure measurement, and in particular to a blood pressure measurement device and method. BACKGROUND

[0002] Blood pressure as an important indicator of physical condition, in recent years, more and more people, especially the elderly population pay attention to. Because the blood pressure curve can reflect many signs of cardiovascular disease, so that real-time, convenient blood pressure monitoring has been growing demand. Among them, based on the blood pressure measurement of photo plethysmography (PPG), after emitting a certain wavelength of light beam, the reflected light beam is obtained by using a photoelectric receiver. Due to the absorption attenuation of skin tissue, muscle and blood vessels to the light beam, the intensity of the reflected light beam is weakened to a certain extent. Among them, the different volume of blood vessels has different influence on the absorption effect of the light beam, the size of the light intensity can be used to analyze and calculate the systolic and diastolic blood pressure, and then the blood pressure measurement is completed.

[0003] However, when blood pressure is measured based on PPG, the light intensity obtained cannot be directly corresponding to the corresponding blood pressure value, generally, the blood pressure of the user is measured by using a sphygmomanometer, and then the data obtained by the sphygmomanometer is input into the corresponding device corresponding to the PPG as the reference data of blood pressure measurement. However, since the sphygmomanometer itself is relatively bulky, and the user needs to manually input the blood pressure parameter obtained by the sphygmomanometer into the device corresponding to the PPG, the existing blood pressure measurement process based on PPG is relatively cumbersome, and in the case of frequent calibration of the blood pressure parameter in the PPG, the convenience of blood pressure measurement is seriously affected. Therefore, at present, there is an urgent need for a method for conveniently and accurately measuring blood pressure based on PPG. SUMMARY

[0004] The purpose of the embodiments of the present specification is to provide a blood pressure measurement device and method to solve the technical problem of how to conveniently and accurately measure blood pressure based on PPG.

[0005] To solve the above technical problems, the embodiment of the present specification provides a blood pressure measuring device, comprising an ultrasonic sensing module, a pressure sensing module, a light signal sensing module, a memory and a processing circuit; the ultrasonic sensing module is used to emit an ultrasonic signal and receive an ultrasonic signal reflected by a detection area, and generate a corresponding ultrasonic electrical signal; the ultrasonic electrical signal is used to reflect the position change of the blood vessel wall; the pressure sensing module is used to generate a pressure signal; the pressure signal is used to represent the pressure between the ultrasonic sensing module and the detection area; the light signal sensing module is used to emit a light signal and receive a light signal reflected by the detection area and generate a corresponding photoelectric signal; the photoelectric signal is used to reflect the blood vessel volume in the detection area; the memory is used to store a blood pressure comparison model; the blood pressure comparison model is constructed according to a plurality of comparison blood pressure values calculated according to a plurality of ultrasonic electrical signals and a plurality of pressure signals, and a plurality of comparison photoelectric signals; the processing circuit is used to calculate the target user blood pressure value according to the blood pressure comparison model and the photoelectric signal.

[0006] The embodiment of the present specification also provides a blood pressure measuring method, comprising: emitting a light signal; receiving a light signal reflected by a detection area and generating a corresponding photoelectric signal; calculating a target user blood pressure value according to the photoelectric signal and a blood pressure comparison model; the blood pressure comparison model comprises an ultrasonic signal and a light signal, and after receiving an ultrasonic signal and a photoelectric signal reflected by a detection area, a blood pressure value is calculated using the generated ultrasonic electrical signal and pressure signal, and a model is generated according to the corresponding relationship between the blood pressure value and the photoelectric signal.

[0007] From the above technical solutions provided by the embodiment of the present specification, in the embodiment of the present specification, the ultrasonic sensing module and the pressure sensing module in the device can be used to generate ultrasonic electrical signals and pressure signals respectively, and then the blood pressure value is calculated according to the ultrasonic electrical signals and the pressure signals, and then the blood pressure comparison model is constructed by combining the photoelectric signal generated by the light signal sensing module, and then the blood pressure of the user is measured directly by using the blood pressure comparison model and the photoelectric signal in actual measurement. Through the above device, the accuracy of blood pressure measurement is ensured, the result of blood pressure measurement is simplified, the user can conveniently and continuously monitor the blood pressure, and the user experience is improved. BRIEF DESCRIPTION OF DRAWINGS

[0008] In order to more clearly illustrate the technical solutions in the embodiments of the present specification or the prior art, the drawings needed in the embodiment or the prior art description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments described in the present specification, and those skilled in the art can also obtain other drawings according to these drawings without creating any creative labor.

[0009] Figure 1 A structural diagram of a blood pressure measuring device according to an embodiment of the present specification;

[0010] Figure 2A A schematic diagram of a blood vessel volume change over time according to an embodiment of the present specification;

[0011] Figure 2B A schematic diagram of light intensity change over time according to an embodiment of the present specification;

[0012] Figure 3 A flowchart of constructing a blood pressure reference model according to an embodiment of the present specification;

[0013] Figure 4A A schematic diagram of a blood vessel wall position change with pressure according to an embodiment of the present specification;

[0014] Figure 4B A schematic diagram of a blood vessel wall position change with pressure according to an embodiment of the present specification;

[0015] Figure 5 A schematic diagram of a pulse wave feature curve according to an embodiment of the present specification;

[0016] Figure 6 A flowchart of updating a blood pressure reference model according to an embodiment of the present specification;

[0017] Figure 7 A schematic diagram of a blood pressure measuring device according to an embodiment of the present specification;

[0018] Figure 8 A flowchart of updating a blood pressure reference model according to an embodiment of the present specification;

[0019] Figure 9 A flowchart of updating a blood pressure reference model according to an embodiment of the present specification;

[0020] Figure 10A A schematic diagram of a blood pressure measuring device layout according to an embodiment of the present specification;

[0021] Figure 10B A schematic diagram of a blood pressure measuring device layout according to an embodiment of the present specification;

[0022] Figure 10C A schematic diagram of a blood pressure measuring device layout according to an embodiment of the present specification;

[0023] Figure 10D A schematic diagram of a blood pressure measuring device layout according to an embodiment of the present specification;

[0024] Figure 10E A schematic diagram of a blood pressure measuring device layout according to an embodiment of the present specification;

[0025] Figure 11 A flow chart of a blood pressure measurement method according to an embodiment of the present specification. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the present specification will be described clearly and completely below in combination with the drawings in the embodiments of the present specification. Obviously, the described embodiments are only part of the embodiments of the present specification, rather than all the embodiments. Based on the embodiments in the present specification, all other embodiments obtained by those of ordinary skill in the art without creative work should fall within the protection scope of the present specification.

[0027] To solve the above technical problems, first, a blood pressure measurement device 100 according to an embodiment of the present specification is introduced. As shown in the figure, the blood pressure measurement device 100 can include an optical signal sensing module 110, an ultrasonic wave sensing module 120, a pressure sensing module 130, a memory 140 and a processing circuit 150. Figure 1

[0028] The optical signal sensing module 110 is used to emit optical signals and receive the optical signals reflected by the detection area and generate corresponding photoelectric signals.

[0029] The optical signal sensing module 110 can be provided with a light source to emit a light beam of a certain wavelength. The light beam has a penetrating property. After the blood pressure measurement device 100 is attached to the skin, the light beam can penetrate the skin, muscle and other tissues to reach the blood vessels. Preferably, the optical signal sensing module 110 can be attached to the position corresponding to the superficial artery during measurement, such as the radial artery of the wrist, the carotid artery of the neck, etc.

[0030] The optical signal sensing module 110 can also realize the reception of light, for example, through a photoelectric receiver to absorb the light transmitted or reflected back by the detection area and generate a corresponding electrical signal based on the intensity of the received light. The light beam emitted by the optical signal sensing module 110 can also be reflected by the skin, muscle, blood vessels and other parts, so as to be received by the optical signal sensing module 110.

[0031] After emitting the optical signals to the detection area, the skin, muscle, fat and blood vessels in the detection area will have corresponding absorption effects on the optical signals, which will reduce the intensity of the reflected light while reflecting the light. During the measurement process, the position of the optical signal sensing module 110 does not change, and the skin, muscle and other parts in the detection area basically do not change, that is, the degree of attenuation of the reflected light does not change. However, within the heart beat cycle, the blood volume flowing in the blood vessels changes in a pulsatile manner. When the heart contracts, the blood volume is maximum, corresponding to the systolic pressure; when the heart relaxes, the blood volume is minimum, corresponding to the diastolic pressure. Based on the change of light intensity, the change of blood vessel volume under the action of heart contraction and relaxation can be determined. For example,​Figure 2A Fig. 2 shows a schematic diagram of the change of the blood vessel volume over time, Figure 2B Fig. 3 shows a schematic diagram of the change of the light intensity measured in the corresponding region over time, and it can be seen that there is a direct correspondence between the two, so the change of the blood vessel volume can be analyzed according to the light signal.

[0032] The detection region can be a region where the blood pressure measuring device 100 is placed to obtain the blood pressure value. Specifically, the detection region can include the skin tissue and the arterial blood vessels below the skin tissue. The arterial blood vessels can include the radial artery of the wrist, the carotid artery of the neck, the arterial blood vessels of the fingers or toes, or the arterial blood vessels near the heart, so as to complete the measurement of the blood pressure value.

[0033] Correspondingly, in order to effectively process the measurement results, the light signal sensing module 110 can generate a corresponding photoelectric signal according to the received reflected light signal. Specifically, for example, a signal charge can be generated based on photoelectric conversion by a photodiode, and then the charge signal is converted into a voltage signal to obtain the photoelectric signal. In actual application, the generation of the photoelectric signal can be completed in combination with specific settings, and is not limited to the above example, and will not be described here.

[0034] Since the light signal sensing module 110 is combined, the blood pressure measurement is performed by using the photoplethysmography method, only the photoelectric signal in a complete cardiac pulse cycle needs to be obtained, so that the user can perform blood pressure measurement at any time and continuously, and the convenience of the measurement process is ensured.

[0035] However, since the skin, muscle and other tissues of different users have different absorption effects on the light signal, it is impossible to establish a fixed standard to directly determine the blood pressure value of the measurement user according to the light signal intensity, and only the change of the blood vessel volume, i.e. the change of the pulse wave of the measured position, can be determined. Therefore, before actual measurement, the corresponding relationship between the blood pressure value and the photoelectric signal of the target user needs to be obtained, and a regression model between the pulse wave feature points and the blood pressure value is established. When formal measurement is performed, only the photoelectric signal is obtained by using the light signal sensing module 110, the pulse wave feature parameters are obtained according to the photoelectric signal, and then the blood pressure value can be measured according to the corresponding relationship between the pulse wave feature parameters and the above regression model.

[0036] Since the above model involves the corresponding relationship between the pulse wave feature points and the blood pressure value, in order to obtain the above model, in addition to emitting the light signal by using the light signal sensing module 110, the blood pressure value of the target user also needs to be obtained. Therefore, the blood pressure measuring device 100 of the embodiment of the present specification further includes an ultrasonic wave sensing module 120 and a pressure sensing module 130.

[0037] The ultrasonic sensing module 120 is configured to emit ultrasonic signals and receive the reflected ultrasonic signals from the detection region, and generate corresponding ultrasonic electrical signals. The ultrasonic signals can be reflected at different intensities and directions based on the characteristics of the substances after contacting the substances. After receiving the reflected ultrasonic signals, the detection of the detection region can be achieved based on the parameters of the emitted signals. When the ultrasonic signals are applied to blood pressure measurement, the detection of the blood vessel wall can be achieved. When different pressures are applied to the skin, the blood vessel wall has different position changes based on the diastolic pressure and the systolic pressure. After obtaining the position change of the blood vessel wall and the pressure between the device and the skin, the blood pressure value of the user including the systolic pressure and the diastolic pressure can be analyzed.

[0038] Correspondingly, in order to obtain the parameters of the reflected ultrasonic signals, the ultrasonic sensing module 120 can also achieve the reception of the signals. Specifically, the reception of the reflected ultrasonic signals after the emitted ultrasonic waves are reflected based on the blood vessel wall in the detection region. In order to facilitate the processing circuit 150 to process and utilize the received detection signals, the ultrasonic sensing module 120 can also generate corresponding ultrasonic electrical signals after receiving the reflected detection signals. The ultrasonic electrical signals can be electrical signals transmitted based on the circuit. The ultrasonic electrical signals can be used to reflect the ultrasonic signal parameters of the reflected ultrasonic signals, which can include signal amplitude, signal frequency, etc., so that the processing circuit 150 can process based on the information contained in the ultrasonic electrical signals to obtain the blood vessel wall position and / or blood vessel wall pulsation information, etc.

[0039] In some embodiments, in order to ensure the accuracy of the blood pressure value measured by the ultrasonic sensor, the ultrasonic sensing module 120 can include an ultrasonic transducer array composed of at least two ultrasonic transducer units. The ultrasonic transducer units are arranged in a corresponding array shape based on a predetermined manner. The array can be at least one of a linear array, a rectangular array, a circular array, and an elliptical array.

[0040] Since in practical applications, users generally cannot accurately identify the position of the artery, when detecting the blood vessel based on the manner in the prior art, the detection device can not accurately emit signals to the blood vessel. By using a plurality of ultrasonic transducer units to form an ultrasonic transducer array, at least one of the detection signals sent by the ultrasonic transducer units in the array can be reflected by the blood vessel in the detection area. After receiving the ultrasonic electrical signals generated by each ultrasonic transducer unit, by analyzing the characteristics of the ultrasonic electrical signals, the signals corresponding to the reflection of the blood vessel can be determined, so as to realize accurate detection of the arterial blood vessel. Correspondingly, the signals of other ultrasonic transducer units can also be used to optimize the final result, so as to further improve the detection result of the blood vessel wall. By using a plurality of ultrasonic transducer units to form an array, it can be ensured that the arterial blood vessel in the detection area is covered by the ultrasonic waves generated by at least one ultrasonic transducer unit, thereby improving the fault tolerance of the measurement and the accuracy of the measurement result.

[0041] The specific type and structure of the ultrasonic sensing module 120 can be set based on the requirements of actual applications, and will not be described here.

[0042] The pressure sensing module 130 is used to obtain the pressure between the ultrasonic sensing module 120 and the detection area, and generate a corresponding pressure signal based on the sensed pressure. The pressure sensing module 130 can include a pressure sensitive element, which can change its properties according to the size of the pressure when subjected to pressure, so as to realize the measurement of the pressure according to the change of its properties. For example, the pressure sensitive element can change its resistance value according to the size of the pressure, or realize the measurement of the pressure based on the piezoelectric effect corresponding to the pressure. The specific measurement method can be set according to the type and working principle of the pressure sensing module 130 in actual applications.

[0043] Specifically, in some embodiments, the pressure sensing module 130 can include at least one of a capacitive sensor, a resistive sensor, and a piezoelectric sensor. The specific measurement method can be set according to actual conditions, and will not be described here.

[0044] Correspondingly, the fitting pressure directly measured by the pressure sensing module 130 cannot be directly utilized, and therefore, in some embodiments, the pressure sensing module 130 can further include a signal processing unit which can generate a corresponding pressure signal according to the fitting pressure. The pressure signal can be an electrical signal transmitted through a circuit, and can be used to describe the magnitude and other properties of the fitting pressure. After being transmitted to the processing circuit 150, the pressure signal can be used by the processing circuit 150 to learn the fitting pressure between the ultrasonic module and the skin tissue, so as to calculate the blood pressure value based on the pressure change between the ultrasonic module and the skin tissue and the blood vessel wall position corresponding to the pressure.

[0045] Preferably, in order to ensure the accuracy of blood pressure measurement, the distance between the ultrasonic sensing module 120 and the pressure sensing module 130 is not greater than a first distance threshold. The first distance threshold is used to limit the distance between the ultrasonic sensing module 120 and the pressure sensing module 130, so as to ensure that the pressure signal collected by the pressure sensing module 130 is equivalent or approximate to the pressure between the ultrasonic sensing module 120 and the detection area. The specific size of the first distance threshold can be set according to the actual application requirements, and no specific limitation is made.

[0046] Correspondingly, the distance between the optical signal sensing module 110 and the ultrasonic sensing module 120 or the pressure sensing module 130 is not greater than a second distance threshold. Since the construction of the blood pressure control model needs to be completed based on the correlation between the ultrasonic electrical signal and the optical electrical signal, it is necessary to ensure that the optical signal sensing module 110 and the ultrasonic sensing module 120 are used to detect the same part, and correspondingly, the optical signal sensing module 110 and the ultrasonic sensing module 120 need to be limited. The pressure signal obtained by the pressure sensing module 130 also has a calibration effect on the pulse wave feature curve constructed based on the optical electrical signal, and similarly, the distance between the pressure sensing module 130 and the optical signal sensing module 110 can be limited. The second distance threshold and the first distance threshold can not have a corresponding relationship, that is, the distances between different modules can be set individually, or the distance threshold can be set by referring to other distance thresholds. The specific size of the second distance threshold can be set according to the actual application requirements, and no specific limitation is made.

[0047] The above device uses the optical electrical signal and the blood pressure control model to output the corresponding blood pressure value when actually measuring the blood pressure. Since the blood pressure control model is used to reflect the corresponding relationship between the blood pressure value and the pulse wave feature parameter corresponding to the optical electrical signal, the blood pressure measurement can be directly completed by the generated optical electrical signal.

[0048] To complete the construction of the blood pressure control model, the target user calibration blood pressure value can be calculated by using the pressure signal and the ultrasonic electrical signal. Since the target user calibration blood pressure value has high accuracy, it can be used as the blood pressure change of the target user in general conditions. By combining the corresponding relationship between the target user calibration blood pressure value and the photoelectric signal, the construction of the blood pressure control model can be realized.

[0049] Specifically, the construction process of the blood pressure control model can be realized by the processing circuit 150. The processing circuit 150 can be a circuit provided with corresponding processing logic, such as a circuit board etched with corresponding circuits. Based on the processing logic provided thereon, the processing circuit 150 can calculate the blood pressure value according to the ultrasonic electrical signal and the pressure signal, and can also calculate the corresponding blood pressure value according to the photoelectric signal and the blood pressure control model.

[0050] In order to better understand the construction process of the blood pressure control model, the construction process of the blood pressure control model is described in detail based on the accompanying drawings. Figure 3 The corresponding construction process is further described. As shown in FIG. 3, the construction process of the blood pressure control model by the processing circuit 150 includes the following specific steps. Figure 3 The corresponding construction process is further described. As shown in FIG. 3, the construction process of the blood pressure control model by the processing circuit 150 includes the following specific steps.

[0051] S310: Obtain a plurality of ultrasonic electrical signals, a plurality of pressure signals, and a plurality of control photoelectric signals.

[0052] The control photoelectric signal is the corresponding photoelectric signal generated by the light signal sensing module 110 after emitting the light signal and receiving the reflected light signal of the detection area while the ultrasonic sensing module 120 emits the ultrasonic signal.

[0053] At the same time when the ultrasonic sensing module 120 emits the ultrasonic signal, the light signal sensing module 110 also emits the light signal, so that the ultrasonic electrical signal and the control photoelectric signal generated based on the ultrasonic signal and the light signal can reflect the measurement results of the same measurement area in the same time period. After determining the blood pressure value change in the subsequent step based on the ultrasonic electrical signal, the blood pressure value can be corresponded to the characteristic value of the control photoelectric signal, so as to complete the construction of the blood pressure control model.

[0054] Correspondingly, based on the foregoing description, the pressure signal corresponds to the generation of the ultrasonic electrical signal, that is, the ultrasonic electrical signal, the pressure signal, and the control photoelectric signal are measured and generated at the same time.

[0055] Specifically, in actual application, the ultrasonic sensing module 120 and the light signal sensing module 110 can be driven by the processing circuit 150 to emit the ultrasonic signal and the light signal at the same time, respectively.

[0056] Preferably, in order to ensure the accuracy of the measurement results and reduce the influence of errors, multiple ultrasonic signals and light signals can be transmitted, and multiple sets of ultrasonic electrical signals and photoelectric signals can be generated. For example, 15 sets of ultrasonic electrical signals and photoelectric signals can be obtained to reduce the interference effect of external factors on the measurement results.

[0057] In some embodiments, after the ultrasonic electrical signals and / or pressure signals and / or photoelectric signals are obtained, the processing circuit 150 can also preprocess the obtained signals. The specific preprocessing method can be to remove noise in the signals by signal filtering to improve the accuracy of the measured blood pressure.

[0058] S320: Corresponding calculation of the multiple reference blood pressure values using multiple ultrasonic electrical signals and multiple pressure signals.

[0059] After the ultrasonic electrical signals and pressure electrical signals are obtained, the reference blood pressure values can be calculated using the ultrasonic electrical signals and pressure signals. Specifically, the processing circuit 150 can determine the blood vessel wall position using the ultrasonic electrical signals, and determine the corresponding pressure value according to the pressure signal. Since the ultrasonic electrical signals and the pressure signals are signals obtained in the same measurement period, there is a corresponding relationship between the pressure value and the blood vessel wall position. The conversion logic between signal value strength and parameters can be pre-set in the processing circuit 150, so that the processing circuit 150 obtains the corresponding parameter value based on the obtained signals.

[0060] The pressure value corresponding to the pressure signal changes linearly over time, for example, it can gradually increase over time or gradually decrease over time. The change in pressure can be changed by human pressing or applied by additional devices such as air bags, which is not limited.

[0061] The blood vessel wall position fitting curve can be constructed according to the blood vessel wall position and the pressure value. The blood vessel wall position fitting curve is used to reflect the change of the blood vessel wall position with the pressure value. For the obtained ultrasonic electrical signals, the blood vessel wall position can be identified and tracked in real time by methods such as Doppler shift analysis. Matched filtering will enhance the signal-to-noise ratio of signals with reference signal characteristics in the echo signal. The blood vessel has the same contraction and diastole phenomenon as the heart beat cycle, so the blood vessel wall position has the same rhythm cycle as the heart beat, and the movement frequency is usually 0.5-3Hz. By analyzing the Doppler shift caused by this phenomenon, the position of the blood vessel wall in the echo signal can be quickly identified and tracked.

[0062] As pressure increases over time, the amplitude of blood vessel wall fluctuations also changes with the pressure. By fitting the peak value of the blood vessel wall position change curve, a corresponding envelope curve of blood vessel wall fluctuation amplitude can be obtained. The peak value of the blood vessel wall fluctuation amplitude envelope curve represents the maximum value of blood vessel wall position fluctuation, and blood pressure values ​​can be obtained based on the fluctuation of blood vessel wall position. Conversely, when pressure decreases over time, the amplitude of blood vessel wall fluctuations also changes with the pressure, and a corresponding blood vessel wall position fitting curve can be obtained using the same method.

[0063] Once the envelope curve of the blood vessel wall fluctuation amplitude is obtained, the control blood pressure value can be identified from the blood vessel wall position fitting curve based on the corresponding feature information in the curve.

[0064] In some implementations, a fixed ratio calculation method can be used to obtain the control blood pressure value. Combined with... Figure 4A The method will be explained. Figure 4A The broken line in the graph represents the pressure change of the ultrasound sensing module 120 relative to the detection area, and the bar chart represents the amplitude of blood vessel wall fluctuations within each preset signal period. Figure 4A It's a process of gradually decreasing pressure. As can be seen, the envelope curve formed by the histogram has a peak point O(M). When the pressure is P... S At this point, on the rising edge of the envelope curve formed by the histogram, there is a characteristic point O(S) where the amplitude of the blood vessel wall fluctuation changes abruptly. Correspondingly, when the pressure is P... D At the same time, on the descending edge of the envelope curve, there is also a characteristic point O(D) where the amplitude of the vessel wall fluctuations abruptly changes. Combined with the attached... Figure 4A Given the pressure variation, if the pressure at point O(S) is greater than the pressure at point O(D), then the pressure P at point O(S) can be... S As the contraction pressure, the pressure P corresponding to point O(D) D As diastolic pressure.

[0065] Figure 4B It is the process of the pressure gradually increasing between the ultrasonic sensing module 120 and the detection area, and Figure 4A The changes in blood pressure exhibit similar correspondences, and abrupt changes can be identified on the corresponding envelope curves. Based on the pressure magnitude corresponding to these abrupt changes, diastolic and systolic blood pressure can be determined. A detailed description can be found above and will not be repeated here.

[0066] When the blood pressure value is calculated by using the fixed ratio calculation method, the peak point of the curve, i.e., the point corresponding to the largest fluctuation amplitude of the blood vessel wall in the curve, can be determined from the blood vessel wall position fitting curve. Based on the amplitude corresponding to the point and the pre-set feature point ratio, the diastolic pressure feature point and the systolic pressure feature point can be determined on the rising edge and the falling edge of the curve, respectively. The feature point ratio is used to represent the ratio of the fluctuation amplitude of the diastolic pressure feature point to the fluctuation amplitude of the peak point of the curve, and the ratio of the fluctuation amplitude of the systolic pressure feature point to the fluctuation amplitude of the peak point of the curve.

[0067] Specifically, the range of the feature point ratio of the diastolic pressure feature point to the peak point of the curve includes 0.45 to 0.85, and the range of the feature point ratio of the systolic pressure feature point to the peak point of the curve includes 0.35 to 0.65, i.e., the formula In the formula, y S is the fluctuation amplitude of the systolic pressure feature point, y D is the fluctuation amplitude of the diastolic pressure feature point, and y M is the fluctuation amplitude of the peak point of the curve.

[0068] After the diastolic pressure feature point and the systolic pressure feature point are determined based on the feature point ratio, the blood pressure value can be determined according to the pressure signals corresponding to the feature points. Specifically, the pressure value of the pressure signal corresponding to the diastolic pressure feature point can represent the diastolic pressure, and the pressure value of the pressure signal corresponding to the systolic pressure feature point can represent the systolic pressure.

[0069] In some embodiments, the measured blood pressure value can also be obtained by using the differential feature point method. Specifically, after the blood vessel wall position fitting curve is obtained, since the blood vessel wall position fitting curve is generally a continuous curve, the differential curve can be obtained by differentiating the blood vessel wall position fitting curve. Based on the values of the points in the differential curve, the feature points are identified. The feature points can include the differential maximum value point corresponding to the maximum value of the differential curve, the differential minimum value point corresponding to the minimum value of the differential curve, and the differential zero value point with a value of zero. Accordingly, the pressure corresponding to the differential maximum value point can be taken as the diastolic pressure, the pressure corresponding to the differential minimum value point can be taken as the systolic pressure, and the pressure corresponding to the differential zero value point can be taken as the mean arterial pressure.

[0070] Accordingly, based on the change of the blood vessel wall position with time, the heart rate information of the measured object can also be identified. The specific identification method can be set according to the actual application, which is not described here.

[0071] After the above systolic pressure, diastolic pressure and pressure change relationship is obtained, the above measured blood pressure parameter value can be taken as a control blood pressure value. The control blood pressure value is a blood pressure measurement based on the blood vessel unloading principle. Although the measurement period is longer and additional pressure needs to be applied, the measurement result is more accurate and is suitable for calibrating the pulse wave corresponding to the photoelectric signal in the subsequent step to obtain a blood pressure control model.

[0072] S330: constructing a plurality of pulse wave characteristic curves according to a plurality of the control photoelectric signals; each pulse wave characteristic curve corresponds to a group of pulse wave characteristic parameters.

[0073] Since the control photoelectric signal can only be used to reflect the light intensity change and cannot directly reflect the parameters related to blood pressure, in order to construct the blood pressure control model, the control photoelectric signal also needs to be processed. Specifically, a pulse wave characteristic curve can be constructed according to the control photoelectric signal. The fluctuation of the arterial blood vessel affects the blood vessel volume, so that the absorption effect of the arterial blood vessel on light also presents a certain change rule in the fluctuation process. After the optical sensor performs signal collection on the measurement site of the user for a period of time, the light intensity change corresponding to the obtained photoelectric signal can be used to reflect the change of the pulse wave, and accordingly the construction of the pulse wave characteristic curve can be realized.

[0074] The pulse wave characteristic curve is constructed based on the photoelectric signal amplitude change curve. Specifically, the pulse wave characteristic curve can be constructed based on pulse wave characteristic parameters, and the pulse wave characteristic curve can correspond to a group of pulse wave characteristic parameters. The pulse wave characteristic parameters can have a corresponding relationship with the parameters in the photoelectric signal amplitude change curve. Specifically, the pulse wave characteristic parameters include time parameters, amplitude parameters, area parameters, heart rate values, etc. Figure 5 As shown in FIG. 4, it is a schematic diagram of a pulse wave characteristic curve. Among them, A point is the starting point, B point is the main wave peak and maximum value point, C point is the secondary wave valley, D point is the secondary wave peak, E point is the end point. Among them, A and E points are the main wave valley and minimum value point. The above feature points in the curve can reflect the corresponding pulse wave characteristic parameters, so that the construction of the pulse wave characteristic curve can be completed based on a group of pulse wave characteristic parameters.

[0075] The pulse wave characteristic parameters can also be used to reflect some other types of characteristic parameters, such as systolic period time proportion, diastolic period time proportion, descending mid-isthmus relative height, and double pulse wave relative height.

[0076] S340: constructing the blood pressure control model based on a plurality of the pulse wave characteristic parameters and a plurality of the control blood pressure values.

[0077] Since the reference photoelectric signal and the ultrasonic electric signal correspond to the measurement results in the same time period, there is a corresponding relationship between the pulse wave characteristic parameters corresponding to the above-mentioned electric signals and the reference blood pressure value. By analyzing the corresponding relationship between the pulse wave characteristic parameters and the reference blood pressure value, the above-mentioned corresponding relationship is expressed in a mathematical manner, that is, the quantitative description of the blood pressure reference model can be realized.

[0078] Specifically, according to the obtained pulse wave characteristic curve and the reference blood pressure value, a linear regression method can be used for construction. The utilization process of the linear regression method can be set based on the requirements of actual application, which will not be described here.

[0079] Based on the above process, the relationship among the ultrasonic electric signal, the pressure signal and the reference photoelectric signal is analyzed, and the corresponding relationship between the blood pressure value and the pulse wave can be finally determined. The construction of the blood pressure reference model can be completed, that is, the function relationship between the pulse wave characteristic parameters and the reference blood pressure value can be described. By using the blood pressure reference model, the photoelectric signal measured by the target user can be directly used to measure the blood pressure value of the user.

[0080] Since in actual application, due to the influence of different personal physical conditions and environment, the blood pressure value or other physical conditions of the user may change to a certain extent, thereby causing the change of the blood pressure value or the measured photoelectric signal. If the original blood pressure reference model is still used, it may cause errors in the measured blood pressure.

[0081] Therefore, in actual application, the processing circuit 150 can realize the calibration of the blood pressure reference model based on the preset logic to ensure the accuracy of the calculation result of the blood pressure reference model.

[0082] In some embodiments, the calibration of the blood pressure reference model can directly use the original method to reconstruct the model. As shown in FIG. 6B, the specific steps of reconstructing the blood pressure reference model are shown. Figure 6

[0083] S610: Drive the ultrasonic sensing module and the light signal sensing module to respectively emit calibration ultrasonic signals and calibration light signals.

[0084] The driving operation of the above-mentioned signals can be performed by the processing circuit 150 every fixed time interval. The length of the fixed time can be set to avoid the change of the biological information of the user after a period of time. For example, the fixed time can be 3 days, 7 days, one month, half a year, etc., which is not limited, and can be set based on the requirements of actual application.

[0085] ​Correspondingly, the calibration ultrasonic signal and the calibration light signal are signals emitted at the same time period for the same detection region. In addition, the pressure sensing module 130 also generates a corresponding calibration pressure signal based on the detected pressure in this time period.

[0086] Specifically, when updating the blood pressure reference model, the ultrasonic sensing module 120 and the light signal sensing module 110 can be first driven to emit calibration ultrasonic signals and calibration light signals, respectively. In actual applications, a signal driving unit can be additionally provided in the device, and after the processing circuit 150 transmits instructions to the signal driving unit, the signal driving unit is responsible for driving the ultrasonic sensing module 120 and the light signal sensing module 110 to emit calibration ultrasonic signals and calibration light signals. Correspondingly, based on the steps in the foregoing process, the ultrasonic sensing module 120 and the light signal sensing module 110 generate corresponding calibration ultrasonic electrical signals and calibration light electrical signals. The pressure sensing module 130 also generates a corresponding calibration pressure signal.

[0087] S620: Obtain a plurality of calibration ultrasonic electrical signals, a plurality of calibration pressure signals, and a plurality of calibration light electrical signals.

[0088] The acquisition method of the calibration ultrasonic electrical signals, the calibration pressure signals, and the calibration light electrical signals can refer to the introduction of the process of acquiring the ultrasonic electrical signals, the pressure signals, and the reference light electrical signals in step S310, which will not be described here.

[0089] S630: Correspondingly calculate a plurality of reference blood pressure values according to the plurality of calibration ultrasonic electrical signals and the plurality of calibration pressure signals.

[0090] The step of calculating the reference blood pressure values using the calibration ultrasonic electrical signals and the calibration pressure signals can refer to the step of calculating the reference blood pressure values using the ultrasonic electrical signals and the calibration pressure signals in step S320, which will not be described here.

[0091] S640: Reconstruct the blood pressure reference model according to the plurality of reference blood pressure values and the plurality of calibration light electrical signals.

[0092] After the fixed time, the blood pressure reference model may thus lack accuracy, and therefore, after the reference blood pressure values and the calibration light electrical signals are obtained through the above steps, since the acquisition method of the reference blood pressure values and the calibration light electrical signals is the same as that when the blood pressure reference model is constructed, the blood pressure reference model reconstructed using the reference blood pressure values and the calibration light electrical signals can ensure the consistency between the reconstructed blood pressure reference model and the current biological characteristics of the target user, and ensure the accuracy of the blood pressure measurement results.

[0093] The specific method for constructing a blood pressure control model based on the multiple reference blood pressure values ​​and multiple calibration photoelectric signals can be referred to in steps S330 and S340, and will not be repeated here.

[0094] To better describe the above process, the following will combine... Figure 7 A schematic diagram of a corresponding blood pressure measuring device is provided. For example... Figure 7 As shown, the blood pressure measuring device can be embodied in the form of a wearable device, such as a watch. The watch face of the wearable device houses the optical signal sensing module 110, the ultrasonic sensing module 120, the pressure sensing module 130, the memory 140, and the processing circuitry 150. Furthermore, an update prompt module is located around the watch face. The blood pressure measuring device updates the blood pressure reference model in the memory at fixed time intervals, thus entering update mode. In update mode, the update prompt module prompts the user to press the button to effectively collect the reflected ultrasonic and optical signals, and then uses the generated electrical signals to update the blood pressure reference model.

[0095] The wearable device update notification module in the picture uses voice broadcast to prompt the user. In actual applications, other methods can also be used to prompt the user as needed, such as setting up a display screen on the watch face to display the relevant information, or prompting the user through vibration by a built-in motor. There are no restrictions on this.

[0096] The reconstructed blood pressure control model described above can promptly match the user's current biometrics, ensuring the model's accuracy. However, in practical applications, the user's biometrics may not change at fixed intervals. If the user's biometrics do not change after a fixed interval, reconstructing the model will obviously consume additional time and computational resources. Therefore, to adapt to the above situation, such as... Figure 8 As shown in the embodiments of this specification, a method for calibrating a blood pressure control model is also proposed, and the specific calibration steps are as follows.

[0097] S810: Acquire multiple calibration ultrasonic electrical signals, multiple calibration pressure signals, and multiple calibration photoelectric signals.

[0098] The description of this step can be found in steps S610 and S620, and will not be repeated here.

[0099] S820: Calculate the reference blood pressure value based on the calibration ultrasound electrical signal and the calibration pressure signal.

[0100] The description of this step can be found in step S630, and will not be repeated here.

[0101] Since the calibration ultrasonic signal and the calibration pressure signal are current measured signals, the reference blood pressure value can accurately describe the current blood pressure condition of the user.

[0102] S830: calculating a predicted blood pressure value according to the blood pressure control model and the calibration photoelectric signal.

[0103] In actual application, since the blood pressure control model still has the function of calculating blood pressure value, the blood pressure value can still be calculated according to the blood pressure control model and the calibration photoelectric signal. The calculated blood pressure value is the predicted blood pressure value.

[0104] If the user's physical condition does not change greatly after the fixed time, the blood pressure control model is still accurate, and the calculated predicted blood pressure value can accurately describe the user's blood pressure condition, that is, there is no great difference between the predicted blood pressure value and the reference blood pressure value. If the change of the user's physical condition after the fixed time has already produced a great change, so that the blood pressure control model can no longer correspond to the current physical condition of the user, the calculated predicted blood pressure value will also lack accuracy, thereby there is a certain difference between the predicted blood pressure value and the reference blood pressure value.

[0105] S840: judging whether the deviation between the reference blood pressure value and the predicted blood pressure value is greater than a blood pressure deviation threshold value.

[0106] The blood pressure deviation threshold value can be a value preset to limit the maximum predicted deviation, which is used to represent the maximum deviation range of the model. For example, the blood pressure deviation threshold value can be set to ±2%, if the deviation exceeds ±2%, it indicates that the current blood pressure control model lacks a certain accuracy and needs to be corrected. If the deviation does not exceed ±2%, the current blood pressure control model still has good accuracy, in order to reduce the calculation amount, the model can be temporarily not updated.

[0107] After obtaining the reference blood pressure value and the predicted blood pressure value, the deviation between the actual blood pressure value and the predicted blood pressure value can be calculated. Since the reference blood pressure value has high accuracy, if the deviation is greater than the blood pressure deviation threshold value, it indicates that the current model has already lacked accuracy, and the blood pressure control model can be updated in step S750. If the deviation is not greater than the blood pressure deviation threshold value, the current model is still accurate and can continue to be applied to blood pressure measurement, and then the method can jump to step S760 to stop updating the model.

[0108] S850: reconstructing the blood pressure control model by using the reference blood pressure value and the calibration photoelectric signal.

[0109] If the deviation is greater than the blood pressure deviation threshold value, the blood pressure control model has already lacked accuracy, and therefore the blood pressure control model can be updated.

[0110] In some embodiments, the updating of the blood pressure control model can be in a re-constructing manner. The specific implementation steps can refer to the description of step S640, which will not be repeated here.

[0111] In some other embodiments, in order to avoid the re-constructing process consuming too much time, the updating process of the blood pressure control model can be a calibration of the model based on the deviation of the blood pressure values.

[0112] The specific calibration process of the blood pressure control model can be a non-linear calibration. A corresponding regression model can be pre-constructed for calibrating the blood pressure control model. After calculating the deviation ΔP=P2-P1 between the reference blood pressure value and the measured blood pressure value, the above deviation can be taken as a characteristic parameter and brought into the regression model. The regression model is used to calculate the corresponding parameters to modify the blood pressure control model, thereby realizing the calibration of the model.

[0113] The above calibration process can also be a linear calibration in a partition. Specifically, after obtaining a plurality of groups of reference blood pressure values and predicted blood pressure values, a plurality of deviations ΔPn=Pn2-Pn1 can be calculated. These deviations are stored in the form of a table as calibration parameters. There is a corresponding relationship between these calibration parameters and the corresponding predicted blood pressure values. In actual application, after the predicted blood pressure value is calculated by using the regression model, the corresponding calibration parameter can be obtained by looking up the table, so as to modify the predicted blood pressure value by using the calibration parameter to obtain the final target user blood pressure value which is more accurate.

[0114] In actual application, other ways can be used to modify the model according to the needs, which are not limited to the above examples, and will not be repeated here.

[0115] After the model is updated based on the above method, since it cannot be ensured that the calibration process is necessarily accurate, the steps S810-S840 can be executed again to calculate the predicted blood pressure value of the updated blood pressure control model and the corresponding deviation. If the recalculated deviation still exceeds the blood pressure deviation threshold, it indicates that the updated model still lacks accuracy, and the steps S810-S850 can be repeatedly executed, that is, the steps of driving the ultrasonic sensing module 120 and the light signal sensing module 110 to emit calibration ultrasonic signals and calibration light signals, respectively, and updating the blood pressure control model based on the calibration ultrasonic electrical signals generated by the ultrasonic sensing module 120, the calibration pressure signals generated by the pressure sensing module 130, and the calibration optical signals generated by the light signal sensing module 110, until the deviation between the reference blood pressure value calculated based on the updated blood pressure control model and the calibration optical signal and the actual blood pressure value is not greater than the blood pressure deviation threshold.

[0116] S860: Stop updating the blood pressure control model.

[0117] In a case where the calculated deviation is not greater than the blood pressure deviation threshold, it is indicated that the current blood pressure reference model has certain accuracy, and thus the updating of the blood pressure reference model can be stopped, and the blood pressure reference model can be continuously put into actual application.

[0118] The above embodiment can adapt to specific changes in a case where the user biological characteristics change. However, the above embodiment still needs to collect multiple groups of signals when updating the model, and then reconstruct or update the model by using the multiple groups of signals, and obtaining the multiple groups of signals can consume a large amount of time, thereby affecting the user experience. In order to solve the above problem, as shown in FIG. 10, a new way can be used to update the model. The specific updating steps are as follows. Figure 9

[0119] S910: Obtain multiple calibration ultrasonic electrical signals, multiple calibration pressure signals, and multiple calibration photoelectric signals.

[0120] The description of this step can refer to the description in step S810, which will not be repeated here.

[0121] S920: Calculate a reference blood pressure value according to the calibration ultrasonic electrical signal and the calibration pressure signal.

[0122] The description of this step can refer to the description in step S820, which will not be repeated here.

[0123] S930: Calculate a predicted blood pressure value according to the blood pressure reference model and the calibration photoelectric signal.

[0124] The description of this step can refer to the description in step S830, which will not be repeated here.

[0125] S940: Determine whether a deviation between the reference blood pressure value and the predicted blood pressure value is greater than a blood pressure deviation threshold.

[0126] The description of this step can refer to the description in step S840, which will not be repeated here.

[0127] S950: Select one of the multiple reference blood pressure values corresponding to the blood pressure reference model, and select one of the multiple reference photoelectric signals.

[0128] The blood pressure reference model is constructed by the correspondence between the multiple reference blood pressure values and the multiple reference photoelectric signals when the blood pressure reference model is constructed in an initial stage. The inaccuracy of the model is essentially caused by the inaccuracy of the reference blood pressure values and / or the reference photoelectric signals, and thus one of the multiple reference blood pressure values can be selected, and one of the multiple reference photoelectric signals can be selected, and these signals can be replaced in a subsequent step.

[0129] ​The selection of the reference blood pressure value and the reference photoelectric signal can be determined based on the generation time of the parameters or signals, so that the earliest parameters and / or signals are replaced to ensure the timeliness of the data. The corresponding parameters and / or signals can also be removed by analyzing the differences between the data. The specific selection method can be set based on the requirements of actual application, and will not be described here.

[0130] For example, in the case of originally having 15 groups of signals, the latest measured group of signals is used to replace the earliest signal in the original 15 groups of signals, and the updated signals are used to complete the construction of the model.

[0131] S960: replacing the selected reference blood pressure value with the reference blood pressure value and replacing the selected reference photoelectric signal with the calibration photoelectric signal.

[0132] After the reference blood pressure value and the calibration photoelectric signal are collected, the reference blood pressure value can be used to replace the selected reference blood pressure value, and the calibration photoelectric signal can be used to replace the selected reference photoelectric signal, so as to improve the accuracy of the reference blood pressure value and the reference photoelectric signal.

[0133] S970: reconstructing the blood pressure reference model according to the plurality of reference blood pressure values and the plurality of reference photoelectric signals after replacement.

[0134] After the reference blood pressure value and the reference photoelectric signal are replaced, the accuracy and real-time performance of the reference blood pressure value and the reference photoelectric signal can be improved, so that after the blood pressure reference model is reconstructed using the plurality of reference blood pressure values and the plurality of reference photoelectric signals after replacement, the accuracy of the blood pressure reference model can be improved.

[0135] Correspondingly, after step S970 is executed, steps S910 to S940 can also be repeatedly executed to determine the accuracy of the currently reconstructed model. If the deviation is not greater than the blood pressure deviation threshold, the current model has good accuracy and can be applied to actual measurement. If the deviation is greater than the blood pressure deviation threshold, the model accuracy is insufficient, and steps S910 to S970 can be repeatedly executed until the updated model has the accuracy required for actual application.

[0136] S980: stopping updating the blood pressure reference model.

[0137] The description of this step can refer to the description in step S860, which will not be described here.

[0138] The blood pressure reference model obtained by the above updating can output corresponding blood pressure values using photoelectric signals again, so as to ensure the accuracy of blood pressure measurement and improve the user experience.

[0139] In practical applications, the blood pressure measuring device 100 can have different working modes to adapt to different measurement requirements. In a first working mode, the processing circuit 150 is configured to calculate the target user's blood pressure value based on the blood pressure reference model and the photoelectric signal, i.e., to complete the measurement of the blood pressure value in the manner described in the foregoing flow.

[0140] In some embodiments, the blood pressure measuring device 100 can also measure the blood pressure in a second working mode. In the second working mode, the blood pressure measuring device 100 measures the blood pressure by using the pressure signal and the photoelectric signal. The pressure detected by the pressure sensor includes static pressure and oscillating pressure generated by the vibration of the blood vessel wall. The oscillating pressure is positively correlated with the blood flow rate in the artery. Since the pulse wave characteristic curve can be obtained based on the photoelectric signal, and the systolic pressure and diastolic pressure generally correspond to the time around the moment when the rate of change of the vibration of the blood vessel wall is the largest, therefore, after finding the feature point of the systolic pressure or diastolic pressure on the pulse wave characteristic curve, the pressure value corresponding to the feature point in the pressure change curve can be used as the target blood pressure value. By obtaining the pressure signal and the photoelectric signal, the blood pressure can be measured in another way without relying on the blood pressure reference model.

[0141] In some specific examples, the calculation of the blood pressure value in the above process can be implemented by using the fixed ratio calculation method or the differential feature point method. For the specific application process of the fixed ratio calculation method or the differential feature point method, please refer to the description in the step of obtaining the measured blood pressure value in the above process, which will not be described here.

[0142] In some embodiments, since the photoelectric signal can reflect the change of the blood vessel volume, and the blood vessel volume is related to the heart beat and the pulse beat, the processing circuit 150 can also determine the heart rate value and / or the pulse wave based on the photoelectric signal.

[0143] The blood pressure measuring device 100 further includes a storage 140 for storing the blood pressure reference model. In the present embodiment, the storage 140 can be implemented in any appropriate manner. For example, the storage can be a read-only memory, a mechanical hard disk, a solid-state disk, or a U disk, etc. The storage 140 can store the blood pressure reference model described above. When the blood pressure is measured by using the light signal sensing module 110, after obtaining the photoelectric signal, the blood pressure reference model can be directly obtained from the storage 140, and the calculation of the target user's blood pressure value can be completed based on the comparison result between the blood pressure reference model and the photoelectric signal.

[0144] In some embodiments, the blood pressure measuring device 100 can also be provided with an analog-to-digital converter for converting the ultrasonic signals generated by the ultrasonic sensor module 120 and / or the pressure signals generated by the pressure sensor module 130 and / or the photoelectric signals generated by the light signal sensor module 110 into corresponding digital signals, so that the processing circuit 150 can perform corresponding calculations based on the digital signals.

[0145] In the blood pressure measuring device 100, the ultrasonic sensor module 120, the light signal sensor module 110, the pressure sensor module 130, the memory 140, and the processing circuit 150 can be integrated on the same chip to reduce the overall size of the blood pressure measuring device 100 and ensure the convenience of the device. In some embodiments, when the blood pressure measuring device 100 is combined with other devices, in order to ensure effective wiring, the sensor module can also be arranged in a different area from the memory 140 and the processing circuit 150, for example, when the blood pressure measuring device 100 is integrated into a wearable smart watch, the sensor module can be arranged on the watchband, and the memory 140 and the processing circuit 150 can be arranged in the watch dial, and a line can be arranged in the watchband to transmit signals to ensure the convenience of the device. In actual applications, the arrangement can be made according to specific conditions, and is not limited to the above examples, which will not be described here.

[0146] Figure 10A 、 Figure 10B 、 Figure 10C 、 Figure 10D 、 Figure 10E is a schematic diagram of the layout of the blood pressure measuring device 100 that can be used in specific applications. As shown in Figure 10A , the pressure sensor module 130, the ultrasonic sensor module 120, or the light signal sensor module 110 can be distributed in parallel on the same substrate, and each ultrasonic sensor module 120 or light signal sensor module 110 can correspond to one or more pressure sensor modules 130 to accurately obtain the contact pressure between the sensor module and the measurement area. After packaging the sensor module, the packaging unit is in contact with the user through the second surface. In actual applications, a corresponding housing or cover plate can also be provided, which will not be described here.

[0147] In actual applications, the sensor module can also directly contact the user. As shown in Figure 10B , an opening can be provided on the second surface to enable the sensor module to directly contact the user to improve the accuracy of the measurement.

[0148] Figure 10C is Figure 10A based on the second surface being arc-shaped to better fit the surface of the human skin and improve the measurement accuracy.

[0149] And the circuit connection of each module can be directly connected through the circuit in the substrate to obtain the corresponding signal; or as Figure 10D shown, the module and the first surface can also be effectively connected through the wire.

[0150] In actual application, as Figure 10E shown, the pressure sensing module 130 and the ultrasonic sensing module 120 or the light signal sensing module 110 can be arranged by stacking. Specifically, the sensing module above the pressure sensing module 130 can be arranged alternately with the ultrasonic sensing module 120 and the light signal sensing module 110, for example, the middle module can be set as the light signal sensing module 110. The stacking arrangement can better obtain the pressure between the sensing module and the measurement area, and ensure the accuracy of the measurement result.

[0151] In some embodiments, the blood pressure measuring device 100 can further include an output module for outputting the measured blood pressure value of the target user. The output module can be a display screen that displays the blood pressure value in the form of an image or text, or a loudspeaker that broadcasts the blood pressure value in the form of voice. The specific form of the output module is not limited.

[0152] Based on the introduction of the above embodiments, it can be seen that the ultrasonic sensing module and the pressure sensing module in the blood pressure measuring device generate ultrasonic electrical signals and pressure signals respectively, and then calculate the blood pressure value according to the ultrasonic electrical signals and the pressure signals, and construct a blood pressure control model in combination with the control photoelectric signal generated by the light signal sensing module, and then directly use the blood pressure control model and the photoelectric signal to complete the measurement of the user's blood pressure during actual measurement. Through the above device, the accuracy of blood pressure measurement is ensured, the result of blood pressure measurement is simplified, the user can conveniently and continuously monitor the blood pressure, and the user experience is improved.

[0153] Based on Figure 1 the corresponding blood pressure measuring device, the present application also provides a blood pressure measuring method. As Figure 11 shown, the blood pressure measuring method can include the following specific steps.

[0154] S1110: Emit a light signal.

[0155] The blood pressure measuring method is realized based on the above blood pressure measuring device. The blood pressure measuring device can include a light signal sensing module, an ultrasonic sensing module, a pressure sensing module, a memory and a processing circuit.

[0156] The light signal is the signal emitted by the light signal sensing module.

[0157] The light signal sensing module can be provided with a light source to emit a light beam of a certain wavelength. The light beam has a penetrating property and can penetrate the skin, muscle and other tissues to reach the blood vessels after the blood pressure measuring device is attached to the skin. Preferably, the light signal sensing module can be attached to the position corresponding to the superficial artery, such as the radial artery of the wrist, the carotid artery of the neck, and the like, during measurement.

[0158] After the light signal is emitted to the detection area, the skin, muscle, fat and blood vessels in the detection area will have a corresponding absorption effect on the light signal, which will reduce the intensity of the reflected light while reflecting the light. During the measurement process, the position of the light signal sensing module remains unchanged, and the skin, muscle and other parts in the detection area will not change, i.e., the degree of attenuation of the reflected light will not change. However, during the heart beat cycle, the blood volume flowing through the blood vessels changes in a pulsatile manner. When the heart contracts, the blood volume is maximum, corresponding to the systolic pressure; when the heart relaxes, the blood volume is minimum, corresponding to the diastolic pressure. Based on the change in light intensity, the change in blood vessel volume under the action of heart contraction and relaxation can be determined.

[0159] The detection area can be the area where the blood pressure measuring device is placed to obtain the blood pressure value. Specifically, the detection area can include skin tissue and arterial blood vessels below the skin tissue. The arterial blood vessels can include the radial artery of the wrist, the carotid artery of the neck, the finger or toe artery, or the artery near the heart, etc., so as to complete the measurement of the blood pressure value.

[0160] Since the photoplethysmography method is used for blood pressure measurement in combination with the light signal sensing module, only the light intensity parameter in a complete heart beat cycle needs to be obtained to realize the measurement of blood pressure, and no pressure signal data needs to be obtained during the measurement, nor does additional pressure need to be applied to the detection area, so that the user can perform blood pressure measurement at any time and continuously, ensuring the convenience of the measurement process.

[0161] However, since the skin, muscle and other tissues of different users have different absorption effects on the light signal, it is impossible to establish a fixed standard to directly determine the blood pressure value of the measurement user according to the light signal intensity, and only the change in blood vessel volume, i.e., the change in pulse wave of the measured position, can be determined according to the change in light intensity. Therefore, before actual measurement, the corresponding relationship between the blood pressure value and the photoelectric signal of the target user needs to be obtained, and after corresponding calibration, a regression model between the pulse wave feature points and the blood pressure value is obtained. During formal measurement, only the photoelectric signal is obtained by using the light signal sensing module, and the blood pressure value can be measured according to the corresponding relationship between the photoelectric signal intensity and the above regression model.

[0162] Therefore, before the specific measurement process, i.e. performing the step S1110, the construction of the blood pressure reference model also needs to be completed.

[0163] For the specific construction process of the blood pressure reference model and the calibration process in the application, please refer to the introduction of the relevant part of the description of the blood pressure reference model, which will not be repeated here.

[0164] S1120: receiving the light signal reflected by the detection area and generating the corresponding photoelectric signal.

[0165] The light signal sensing module can also realize the reception of light, for example, through a photoreceptor to absorb the light transmitted or reflected back by the detection area, and generate a corresponding electrical signal based on the intensity of the received light. The light beam emitted by the light signal sensing module can also be reflected by the skin, muscle, blood vessels and other parts, so as to be received by the light signal sensing module.

[0166] Correspondingly, in order to be able to combine the measurement results for effective processing, the light signal sensing module can generate a corresponding photoelectric signal according to the received reflected light signal. Specifically, for example, a photodiode can generate signal charges based on photoelectric conversion, and then convert the charge signal into a voltage signal to obtain the photoelectric signal. In actual application, the generation of the photoelectric signal can be completed in combination with specific settings, and is not limited to the above examples, which will not be repeated here.

[0167] S1130: calculating the blood pressure value of the target user according to the photoelectric signal and the blood pressure reference model; the blood pressure reference model includes emitting ultrasonic signals and light signals, receiving the ultrasonic signals and light signals reflected by the detection area, generating corresponding ultrasonic electrical signals and reference photoelectric signals based on the ultrasonic signals and light signals respectively, and then calculating the blood pressure value using the generated ultrasonic electrical signals and pressure signals, and generating a model according to the corresponding relationship between the blood pressure value and the reference photoelectric signal.

[0168] After obtaining the photoelectric signal, based on the above description of the blood pressure reference model, the blood pressure value of the target user can be calculated. Specifically, the blood pressure value of the target user can be directly calculated using the blood pressure reference model, or the blood pressure value of the target user can be obtained by calculating the predicted value using the blood pressure reference model and then calibrating the predicted value according to the corresponding calibration value. The specific calculation process can be set according to the actual application, which will not be repeated here.

[0169] Although the process flow described above includes a plurality of operations appearing in a specific order, it should be clearly understood that these processes can include more or fewer operations, which can be executed sequentially or in parallel (for example, using parallel processors or multi-threaded environments).

[0170] The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks. Figure 1 The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks. Figure 1 The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks.

[0171] The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks. Figure 1 The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks. Figure 1 The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks.

[0172] The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks. Figure 1 The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks. Figure 1 The computer program instructions can also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified in the flowchart block or blocks.

[0173] In a typical configuration, a computing device includes one or more processors (CPUs), input / output interfaces, network interfaces, and memory.

[0174] The memory can include non-persistent memory, Random Access Memory (RAM), and / or non-volatile memory, e.g., Read Only Memory (ROM) or flash memory, among others in a computer readable medium. The memory is an example of computer readable media.

[0175] Computer-readable media includes permanent and non-permanent, movable and non-movable media that can be implemented by any method or technology to store information. Information can be computer-readable instructions, data structures, program modules or other data. Examples of computer storage media include, but are not limited to, phase-change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technology, compact disc read-only memory (CD-ROM), digital versatile disc (DVD) or other optical storage, magnetic cassette, magnetic tape magnetic disk storage or other magnetic storage devices, or any other non-transmission medium that can be used to store information accessible to a computing device. According to the definition herein, computer-readable media does not include transitory media such as modulated data signals and carriers.

[0176] Those skilled in the art will appreciate that embodiments of the present specification can be provided as methods, systems or computer program products. Therefore, embodiments of the present specification can take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects. Moreover, embodiments of the present specification can take the form of a computer program product implemented on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROMs, optical storage etc.) containing computer-usable program code.

[0177] Embodiments of the present specification can be described in the general context of computer-executable instructions, such as program modules, being executed by a computer. Generally, program modules include routines, programs, objects, components, data structures, etc. that perform particular tasks or implement particular abstract data types. Embodiments of the present specification can also be practiced in distributed computing environments where tasks are performed by remote processing devices that are connected through a communication network. In a distributed computing environment, program modules can be located in both local and remote computer storage media including storage devices.

[0178] Each of the embodiments in the present specification is described in a progressive manner, and the same or similar parts between the embodiments can be referred to each other. Each of the embodiments focuses on the difference from other embodiments. In particular, the system embodiments are described simply because they are substantially similar to the method embodiments. The relevant parts can be referred to the description of the method embodiments. In the description of the present specification, the description of the terms "one embodiment", "some embodiments", "an example", "a specific example", or "some examples" means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the embodiments of the present specification. The illustrative description of the above terms in the present specification does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any appropriate manner in any one or more embodiments or examples. Furthermore, the person skilled in the art can combine and integrate the different embodiments or examples described in the present specification and the features of the different embodiments or examples without contradiction.

[0179] The above only describes the embodiments of the present application and is not intended to limit the present application. The present application can have various modifications and changes for those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the scope of claims of the present application.

Claims

1. A blood pressure measuring device, characterized by, The ultrasonic sensing module, the pressure sensing module, the light signal sensing module, the memory and the processing circuit are included. The ultrasonic sensing module is used for emitting ultrasonic signals and receiving the ultrasonic signals reflected by the detection area, and generating corresponding ultrasonic electrical signals; the ultrasonic electrical signals are used for reflecting the position change of the blood vessel wall. The pressure sensing module is used for generating pressure signals; the pressure signals are used for representing the pressure between the ultrasonic sensing module and the detection area. The light signal sensing module is used for emitting light signals and receiving the light signals reflected by the detection area, and generating corresponding photoelectric signals; the photoelectric signals are used for reflecting the blood vessel volume in the detection area. The memory is used for storing a blood pressure reference model; the blood pressure reference model is constructed according to a plurality of reference blood pressure values calculated according to a plurality of ultrasonic electrical signals and a plurality of pressure signals, and a plurality of reference photoelectric signals. The processing circuit is used for calculating a target user blood pressure value according to the blood pressure reference model and the photoelectric signals. The blood pressure reference model is constructed by the processing circuit through the following methods: A plurality of ultrasonic electrical signals, a plurality of pressure signals and a plurality of reference photoelectric signals are obtained. The plurality of reference blood pressure values are calculated according to the plurality of ultrasonic electrical signals and the plurality of pressure signals. The blood pressure reference model is constructed according to the plurality of reference photoelectric signals and the plurality of reference blood pressure values. The plurality of reference blood pressure values are calculated according to the plurality of ultrasonic electrical signals and the plurality of pressure signals, which further includes: The blood vessel wall position is determined according to the ultrasonic electrical signals. The pressure value is determined according to the pressure signals; the pressure value and the blood vessel wall position have a corresponding relationship. The blood vessel wall position fitting curve is constructed based on the blood vessel wall position and the pressure value; the blood vessel wall position fitting curve is used for reflecting the change of the blood vessel wall position with the pressure value. The reference blood pressure value is identified from the blood vessel wall position fitting curve.

2. The apparatus of claim 1, wherein, The distance between the ultrasonic sensing module and the pressure sensing module is not greater than a first distance threshold; the distance between the light signal sensing module and the ultrasonic sensing module or the pressure sensing module is not greater than a second distance threshold.

3. The apparatus of claim 1, wherein, Each reference photoelectric signal is the corresponding photoelectric signal generated by the light signal sensing module after emitting light signals and receiving the light signals reflected by the detection area while the ultrasonic sensing module emits ultrasonic signals. The blood pressure reference model is constructed according to the plurality of reference photoelectric signals and the plurality of reference blood pressure values, which includes: A plurality of pulse wave characteristic curves are constructed according to the plurality of reference photoelectric signals; each pulse wave characteristic curve corresponds to a group of pulse wave characteristic parameters. The blood pressure reference model is constructed based on a plurality of groups of pulse wave characteristic parameters and a plurality of reference blood pressure values.

4. The apparatus of claim 3, wherein, Each group of pulse wave characteristic parameters includes a time parameter, an amplitude parameter, an area parameter and a heart rate value; the pulse wave characteristic parameters are used for constructing the pulse wave characteristic curve; the blood pressure reference model is constructed based on a plurality of pulse wave characteristic curves by using a linear regression method.

5. The apparatus of claim 1, wherein, The pressure value changes linearly with time.

6. The apparatus of claim 1, wherein, The blood pressure measuring device comprises a first working mode and a second working mode; In the first working mode, the processing circuit is configured to calculate the blood pressure value of the target user according to the blood pressure reference model and the photoelectric signal; In the second working mode, the processing circuit is further configured to calculate the blood pressure value of the target user according to the pressure signal and the photoelectric signal; The method comprises: constructing a pulse wave characteristic curve according to the photoelectric signal; determining a systolic pressure characteristic point and / or a diastolic pressure characteristic point on the pulse wave characteristic curve; and determining the blood pressure value of the target user based on the pressure signal corresponding to the systolic pressure characteristic point and / or the diastolic pressure characteristic point. The processing circuit is further configured to drive the ultrasonic sensor module and the light signal sensor module to emit calibration ultrasonic signals and calibration light signals respectively at fixed time intervals, and to update the blood pressure reference model based on the calibration ultrasonic electrical signals generated by the ultrasonic sensor module, the calibration pressure signals generated by the pressure sensor module, and the calibration photoelectric signals generated by the light signal sensor module.

7. The apparatus of claim 1, wherein, The method of updating the blood pressure reference model based on the calibration ultrasonic electrical signals generated by the ultrasonic sensor module, the calibration pressure signals generated by the pressure sensor module, and the calibration photoelectric signals generated by the light signal sensor module further comprises:

8. The apparatus of claim 7, wherein, acquiring a plurality of calibration ultrasonic electrical signals, a plurality of calibration pressure signals, and a plurality of calibration photoelectric signals at fixed time intervals; calculating a plurality of reference blood pressure values according to the plurality of calibration ultrasonic electrical signals and the plurality of calibration pressure signals; and reconstructing the blood pressure reference model according to the plurality of reference blood pressure values and the plurality of calibration photoelectric signals. The method of updating the blood pressure reference model based on the calibration ultrasonic electrical signals generated by the ultrasonic sensor module, the calibration pressure signals generated by the pressure sensor module, and the calibration photoelectric signals generated by the light signal sensor module comprises:

9. The apparatus of claim 7, wherein, calculating a reference blood pressure value according to the calibration ultrasonic electrical signal and the calibration pressure signal; calculating a predicted blood pressure value according to the blood pressure reference model and the calibration photoelectric signal; updating the blood pressure reference model using the reference blood pressure value and the calibration photoelectric signal when the deviation between the reference blood pressure value and the predicted blood pressure value is greater than a blood pressure deviation threshold. After obtaining an updated blood pressure reference model by updating the blood pressure reference model using the reference blood pressure value and the calibration photoelectric signal, the method further comprises:

10. The apparatus of claim 9, wherein, repeating the steps of driving the ultrasonic sensor module and the light signal sensor module to emit calibration ultrasonic signals and calibration light signals respectively, and updating the blood pressure reference model based on the calibration ultrasonic electrical signals generated by the ultrasonic sensor module and the calibration pressure signals generated by the pressure sensor module and the calibration photoelectric signals generated by the light signal sensor module until the deviation between the predicted blood pressure value calculated based on the updated blood pressure reference model and the calibration photoelectric signal and the reference blood pressure value is not greater than the blood pressure deviation threshold. ​ 11. The apparatus of claim 9, wherein, The updating the blood pressure reference model by using the reference blood pressure value and the calibration photoelectric signal further comprises: In the case that the deviation between the reference blood pressure value and the predicted blood pressure value is greater than the blood pressure deviation threshold, one of the multiple reference blood pressure values corresponding to the blood pressure reference model is selected, and one of the multiple calibration photoelectric signals is selected; The selected reference blood pressure value is replaced by the reference blood pressure value, and the selected calibration photoelectric signal is replaced by the calibration photoelectric signal; and The blood pressure reference model is reconstructed according to the multiple reference blood pressure values after replacement and the multiple calibration photoelectric signals.

12. The apparatus of claim 1, wherein, The ultrasonic sensor module comprises an ultrasonic transducer array composed of at least two ultrasonic transducer units; the ultrasonic transducer units are used to respectively emit the ultrasonic signals to the detection area; the ultrasonic transducer units are also used to receive the ultrasonic signals reflected by the detection area and generate corresponding ultrasonic electric signals.

13. The apparatus of claim 1, wherein, The processing circuit is also used to determine a heart rate value and / or a pulse wave according to the photoelectric signal.

14. A method of blood pressure measurement, characterized by, Comprise: Emitting an optical signal; Receiving the optical signal reflected by the detection area and generating a corresponding photoelectric signal; Calculating a target user blood pressure value according to the photoelectric signal and a blood pressure reference model; The blood pressure reference model comprises emitting ultrasonic signals and optical signals, receiving ultrasonic signals and optical signals reflected by the detection area, generating corresponding ultrasonic electric signals and reference photoelectric signals based on the ultrasonic signals and optical signals, and then calculating blood pressure values by using the generated ultrasonic electric signals and pressure signals, and generating a model according to the corresponding relationship between the blood pressure values and the reference photoelectric signals; The blood pressure reference model is constructed by: Obtaining multiple ultrasonic electric signals, multiple pressure signals and multiple reference photoelectric signals; Corresponding calculation of the multiple reference blood pressure values by using the multiple ultrasonic electric signals and the multiple pressure signals; The blood pressure reference model is constructed according to the multiple reference photoelectric signals and the multiple reference blood pressure values; The corresponding calculation of the multiple reference blood pressure values by using the multiple ultrasonic electric signals and the multiple pressure signals further comprises: Determination of the blood vessel wall position by using the ultrasonic electric signal; Determination of the pressure value according to the pressure signal; there is a corresponding relationship between the pressure value and the blood vessel wall position; The blood vessel wall position fitting curve is constructed based on the blood vessel wall position and the pressure value; the blood vessel wall position fitting curve is used to reflect the change of the blood vessel wall position with the pressure value; The reference blood pressure value is identified from the blood vessel wall position fitting curve.

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