A distillation apparatus for chemical and pharmaceutical applications

Abstract

This invention relates to the field of distillation equipment technology, specifically to a distillation apparatus for chemical and pharmaceutical applications. The apparatus includes a reaction vessel with an internal frame. A hydrophobic membrane is fixedly connected to the inlet side of the frame. The frame divides the reaction vessel into a hot side and a cold side; the inlet side is the hot side, and the outlet side is the cold side. A set of elastic bars, evenly distributed along the longitudinal axis of the frame, is fixedly connected to the inlet side of the hydrophobic membrane. Movable mechanisms are located on both sides of the frame. A movable frame, sliding up and down along the longitudinal axis of the frame, is slidably connected to the side of the frame near the outlet. Evenly distributed partitions are fixedly connected to the longitudinal axis of the movable frame, and evenly distributed protrusions are fixedly connected to both sides of the movable frame. This invention solves the technical problem of membrane pore blockage during membrane distillation of heat-sensitive drugs, leading to poor quality of the distilled drug.

Description

Technical Field

[0001] This invention relates to the field of distillation equipment, specifically a distillation device for chemical and pharmaceutical applications. Background Technology

[0002] Membrane distillation is a novel distillation technology that combines traditional distillation techniques with membrane separation technology. It primarily utilizes the vapor pressure difference across a hydrophobic membrane as the mass transfer driving force. During membrane distillation of a solution, vapor enters the hot side of the reactor through the inlet, passes through the hydrophobic membrane, and enters the cold side, where it condenses, thus completing the distillation process. Because membrane distillation equipment provides a large evaporation area, it requires only a small driving force to achieve high yields. Therefore, membrane distillation at slightly above room temperature can process many heat-sensitive substances, such as the concentration and separation of heat-sensitive drugs, and the membrane distillation of the food additive triacetyl ester.

[0003] During the membrane distillation of heat-sensitive drugs, some microscopic particles or impurities may adhere to the surface of the hydrophobic membrane or the inside of the membrane pores as the steam moves. As the membrane distillation equipment continues to operate, more and more impurities accumulate on the hydrophobic membrane, causing membrane pore blockage, increasing mass transfer resistance, increasing the risk of membrane wetting, and consequently resulting in poor quality of the distilled drug. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a distillation apparatus for chemical and pharmaceutical applications, which solves the technical problem that when performing membrane distillation on heat-sensitive drugs, the pores on the hydrophobic membrane become blocked, resulting in poor quality of the distilled drugs.

[0005] A distillation apparatus for chemical and pharmaceutical applications includes a reaction vessel with an inlet and an outlet at the bottom. The interior of the reaction vessel is equipped with a frame, the four sides of which are fixedly connected to the inner wall of the reaction vessel. A hydrophobic membrane is fixedly connected to the side of the frame facing the inlet. The frame divides the reaction vessel into a hot side and a cold side, with the side of the frame facing the inlet being the hot side and the side of the frame facing the outlet being the cold side.

[0006] On the side of the hydrophobic membrane facing the inlet, there are elastic strips evenly distributed along the longitudinal axis of the frame. Movable mechanisms are provided on both sides of the frame. The elastic strips cooperate with the movable mechanisms to undergo elastic deformation and thus clean the impurities adhering to the hydrophobic membrane.

[0007] A movable frame that slides up and down along the longitudinal axis of the frame is slidably connected to the side of the frame near the outlet. The movable frame is fixedly connected with evenly distributed partitions along the longitudinal axis. The side of the partitions near the frame is in contact with the side of the hydrophobic membrane facing the outlet. Evenly distributed protrusions are fixedly connected to both sides of the movable frame. The protrusions cooperate with the movable mechanism to cause the elastic bar to undergo elastic deformation, causing the elastic bar to drive the hydrophobic membrane to bulge towards the hot side of the reactor.

[0008] A drive motor is installed on the outer wall of the reactor. A rotating shaft is fixedly connected to the output end of the drive motor. A cam is fixedly connected to the end of the rotating shaft away from the drive motor. The cam is in contact with the bottom of the movable frame.

[0009] Preferably, the movable mechanism includes a sliding block, which is located at both ends of the elastic bar and slidably connected to the elastic bar. A compression piece is fixedly installed on the end of the sliding block that passes through the elastic bar near the inlet. The length of the sliding block is greater than the length between the two sides of the frame.

[0010] The frame has a movable groove, the sliding block is located inside the movable groove, and a limit groove is provided inside the movable groove; an elastic element is provided inside the limit groove, one end of the elastic element is ball-jointed with the sliding block, and the other end is ball-jointed with the top of the limit groove, and the elastic element is a compression spring; the elastic element can only move inside the limit groove.

[0011] Preferably, the bottom of the sliding block is provided with a groove, and a fixing block is provided in the groove that is fixedly connected to the bottom of the movable groove. The connection point between the elastic element and the sliding block is located at the end of the groove near the extrusion plate.

[0012] Preferably, the elastic force of the spring bar is greater than the pressure on the hot side of the reactor when the hydrophobic film is blocked.

[0013] Preferably, the area of ​​the partition on the movable frame is larger than the area of ​​the hydrophobic membrane when it protrudes towards the hot side of the reactor; when the hydrophobic membrane protrudes towards the hot side of the reactor, the partition on the movable frame coincides with the protruding part of the hydrophobic membrane.

[0014] Preferably, the protrusion on the movable frame is located on the side of the sliding block near the center line of the frame, and the shape of the side of the sliding block near the center line of the frame is arc-shaped.

[0015] Preferably, a protective sleeve is connected to the outer wall of the sliding block near the extrusion plate, and the other end of the protective sleeve is fixedly connected to the frame, thereby sealing the movable groove.

[0016] The beneficial effects of this invention are as follows:

[0017] 1. The distillation equipment for chemical and pharmaceutical applications described in this invention involves a movable frame that, during its movement, convex points on the movable frame collide with sliding blocks, causing the sliding blocks to rotate around a fixed block as the center. The end of the sliding block near the inlet presses against a spring strip, causing the spring strip to drive the hydrophobic membrane to bulge towards the hot side of the reactor. As the movable frame continues to move, the convex points separate from the sliding blocks, and the spring strip rebounds under its own elastic potential energy, compressing the gas in the partition and the convex portion and backflushing the membrane pores on the hydrophobic membrane, thereby clearing the blocked membrane pores on the hydrophobic membrane.

[0018] 2. In the distillation equipment for chemical and pharmaceutical applications described in this invention, after the membrane pores on the hydrophobic membrane are cleaned, the pressure on the hot side decreases, and the sliding block experiences less pressure when moving towards the inlet. This allows for rapid rebound under the action of the elastic element, thereby preventing the membrane pores on the hydrophobic membrane from being in a partially blocked state. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the main structure of the present invention;

[0021] Figure 2 This is a side view of the main structure of the present invention;

[0022] Figure 3 This is a schematic diagram of the movable frame;

[0023] Figure 4 This is a schematic diagram of the framework structure;

[0024] Figure 5 for Figure 4 Enlarged view of point A in the middle;

[0025] Figure 6 This is a schematic diagram of the elastic bar structure;

[0026] Figure 7 This is a schematic diagram of the initial state of the elastic element;

[0027] Figure 8 This is a schematic diagram of another state of the elastic element.

[0028] In the diagram: 1. Reactor; 11. Inlet; 12. Outlet; 2. Frame; 21. Hydrophobic membrane; 22. Spring bar; 3. Movable mechanism; 31. Sliding block; 32. Extrusion plate; 33. Movable groove; 34. Limiting groove; 35. Elastic element; 36. Slide groove; 37. Fixed block; 4. Movable frame; 41. Partition plate; 42. Protrusion; 5. Drive motor; 51. Rotating shaft; 52. Cam; 6. Sheath. Detailed Implementation

[0029] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0030] Example 1:

[0031] like Figures 1 to 8 As shown,

[0032] A distillation apparatus for chemical and pharmaceutical applications includes a reaction vessel 1, with an inlet 11 and an outlet 12 at the bottom of the reaction vessel 1; a frame 2 is provided inside the reaction vessel 1, with the four sides of the frame 2 fixedly connected to the inner wall of the reaction vessel 1, and a hydrophobic membrane 21 fixedly connected to the side of the frame 2 facing the inlet 11; the frame 2 divides the reaction vessel 1 into a hot side and a cold side, with the side of the frame 2 facing the inlet 11 being the hot side and the side of the frame 2 facing the outlet 12 being the cold side;

[0033] On the side of the hydrophobic membrane 21 facing the inlet 11, there are elastic strips 22 evenly distributed along the longitudinal axis of the frame 2. Movable mechanisms 3 are provided on both sides of the frame 2. The elastic strips 22 cooperate with the movable mechanisms 3 to undergo elastic deformation and thus clean the impurities adhering to the hydrophobic membrane 21.

[0034] A movable frame 4 that slides up and down along the longitudinal axis of the frame 2 is slidably connected to the side of the frame 2 near the outlet 12. The movable frame 4 is fixedly connected with evenly distributed partitions 41 along the longitudinal axis. The side of the partitions 41 near the frame 2 is in contact with the side of the hydrophobic membrane 21 facing the outlet 12. Evenly distributed protrusions 42 are fixedly connected to both sides of the movable frame 4. The protrusions 42 cooperate with the movable mechanism 3 to cause the elastic bar 22 to undergo elastic deformation, causing the elastic bar 22 to drive the hydrophobic membrane 21 to bulge towards the hot side of the reactor 1.

[0035] A drive motor 5 is provided on the outer wall of the reactor 1. A rotating shaft 51 is fixedly connected to the output end of the drive motor 5. A cam 52 is fixedly connected to the end of the rotating shaft 51 away from the drive motor 5. The cam 52 is in contact with the bottom of the movable frame 4.

[0036] The active mechanism 3 includes a sliding block 31, which is located at both ends of the elastic bar 22 and is slidably connected to the elastic bar 22. An extrusion plate 32 is fixedly installed at the end of the sliding block 31 that passes through the elastic bar 22 and is close to the inlet 11. The length of the sliding block 31 is greater than the length between the two sides of the frame 2.

[0037] The frame 2 has a movable groove 33, the sliding block 31 is located inside the movable groove 33, and a limiting groove 34 is provided inside the movable groove 33; an elastic member 35 is provided inside the limiting groove 34, one end of the elastic member 35 is ball-jointed with the sliding block 31, and the other end is ball-jointed with the top of the limiting groove 34, and the elastic member 35 is a compression spring; the elastic member 35 can only move inside the limiting groove 34.

[0038] The bottom of the sliding block 31 is provided with a groove 36, and a fixing block 37 is provided in the groove 36 to be fixedly connected to the bottom of the movable groove 33. The connection point between the elastic element 35 and the sliding block 31 is located at the end of the groove 36 near the extrusion piece 32.

[0039] in:

[0040] A. The elastic force of the spring bar 22 is greater than the pressure on the hot side of the reactor 1 when the hydrophobic membrane 21 is blocked.

[0041] B. The area of ​​the partition plate 41 on the movable frame 4 is greater than the area of ​​the hydrophobic membrane 21 when it protrudes towards the hot side of the reactor 1; when the hydrophobic membrane 21 protrudes towards the hot side of the reactor 1, the partition plate 41 on the movable frame 4 coincides with the protruding part of the hydrophobic membrane 21.

[0042] C. The protrusion 42 on the movable frame 4 is located on the side of the sliding block 31 near the center line of the frame 2, and the shape of the side of the sliding block 31 near the center line of the frame 2 is arc-shaped.

[0043] D. A sleeve 6 is connected to the outer wall of the sliding block 31 near the extrusion plate 32. The other end of the sleeve 6 is fixedly connected to the frame 2. The sleeve 6 seals the movable groove 33.

[0044] When performing membrane distillation on heat-sensitive drugs, steam enters the hot side of reactor 1 from inlet 11 and enters the cold side of reactor 1 through hydrophobic membrane 21. After condensation on the cold side of reactor 1, the steam flows out from outlet 12. The hydrophobic membrane 21 in reactor 1 performs membrane separation on the steam entering the cold side, leaving impurities in the steam on the side of hydrophobic membrane 21 close to inlet 11.

[0045] Simultaneously, during membrane distillation, the drive motor 5 is started. The drive motor 5 drives the cam 52 to rotate via the rotating shaft 51. During the rotation of the cam 52, the movable frame 4 moves up and down reciprocally along the longitudinal axis of the frame 2. During the up-and-down reciprocating motion of the movable frame 4, the baffles 41 on the movable frame 4 repeatedly cut the pore diameter of the hydrophobic membrane 21 near the outlet 12, causing the pore diameter of the hydrophobic membrane 21 to change continuously (the baffles 41 cut the large-diameter membrane pores on the hydrophobic membrane 21 into small-diameter ones). This reduces the possibility of large liquid molecules in the vapor entering the pores of the hydrophobic membrane 21 and causing membrane wetting when the pressure difference across the membrane reaches a certain level. At the same time, because the baffles 41 on the movable frame 4 are spaced apart (e.g., ... Figure 3 As shown in the figure, this does not impede the efficiency of steam entering the cold side of reactor 1 through the hydrophobic membrane 21.

[0046] When the pores on the hydrophobic membrane 21 become blocked, steam cannot pass through the hydrophobic membrane 21 to enter the cold side of the reactor 1, which leads to an increase in pressure on the hot side of the reactor 1. This pressure causes the extrusion plate 32 on the sliding block 31 to be squeezed. The extrusion plate 32 drives the sliding block 31 to move towards the side of the frame 2 toward the outlet 12. The initial state of the sliding block 31 and the state of the elastic element 35 are as follows. Figure 7 As shown;

[0047] As the sliding block 31 moves toward the side of the frame 2 facing the outlet 12, it causes the elastic element 35 to deflect. During the deflection of the elastic element 35, it is compressed, thus accumulating energy (elastic element 35 compression spring). As the sliding block 31 continues to move, the energy accumulation of the elastic element 35 reaches its maximum when it is perpendicular to the sliding block 31. As the sliding block 31 continues to move, the elastic element 35 continues to deflect, and the accumulated energy is released. At this time, the sliding block 31 is simultaneously subjected to the compression from the hot side of the reactor 1 and the energy release from the elastic element 35, causing the sliding block 31 to move rapidly toward the inlet 11. The state of the elastic element 35 is as follows. Figure 8 As shown;

[0048] As the sliding block 31 moves toward the outlet 12, the groove 36 on the sliding block 31 moves synchronously toward the outlet 12. When the hydrophobic membrane 21 is not blocked, the fixed block 37 is located at the end of the groove 36 near the outlet 12, as shown in the specific state. Figure 7 As shown; after the hydrophobic membrane 21 is blocked, the sliding block 31 moves towards the outlet 12, thereby causing the fixed block 37 to gradually contact the end of the chute 36 near the inlet 11. At this time, the connection point between the elastic element 35 and the sliding block 31 is on the same straight line as the fixed block 37, as shown in the specific state. Figure 8 As shown;

[0049] When the connection point between the elastic element 35 and the sliding block 31 is on the same straight line as the fixed block 37, the end of the sliding block 31 away from the extrusion plate 32 extends out of the movable slot 33 as the sliding block 31 moves. At the same time, the movable frame 4 continues to move up and down along the longitudinal axis of the frame 2. During the movement of the movable frame 4, the protrusion on the movable frame 4 contacts and collides with the side of the sliding block 31 near the center line of the frame 2. Since the side of the sliding block 31 near the center line of the frame 2 is arc-shaped, and the connection point between the elastic element 35 and the sliding block 31 is on the same straight line as the fixed block 37, after the two collide, the sliding block 31 acts as a lever, and the sliding block 31 rotates around the fixed block 37 as the center. The end of the sliding block 31 near the inlet 11 is in contact with the elastic bar. 22 is squeezed, causing the spring bar 22 to drive the hydrophobic membrane 21 to bulge towards the hot side of the reactor 1. At this time, the partition 41 on the movable frame 4 coincides with the bulge. As the movable frame 4 continues to move, the bulge separates from the sliding block 31, and the spring bar 22 rebounds under its own elastic potential energy, compressing the gas on the partition 41 and the bulge. Since the elastic force of the spring bar 22 is greater than the pressure when the hot side is blocked, the kinetic energy generated by the spring bar 22 when compressing the gas on the partition 41 and the bulge can backflush the membrane pores on the hydrophobic membrane 21, thereby cleaning the blocked membrane pores on the hydrophobic membrane 21. At the same time, the spring bar 22 can also shake off the impurities on the side of the hydrophobic membrane 21 facing the inlet 11 during the reciprocating process.

[0050] When the protrusion 42 collides with the sliding block 31, the sliding block 31 is subjected to a deflection force and a squeezing force in the direction of the inlet 11. After the collision, the sliding block 31 deflects and moves in the direction of the inlet 11. While moving in the direction of the inlet 11, the sliding block 31 squeezes the elastic element 35. However, since the membrane pores on the hydrophobic membrane 21 are not yet cleaned, the pressure on the hot side is still relatively high, which prevents the sliding block 31 from rebounding quickly under the squeezing of the protrusion 42. After the membrane pores on the hydrophobic membrane 21 are cleaned, the pressure on the hot side decreases, and the pressure on the sliding block 31 when moving in the direction of the inlet 11 is smaller. Therefore, it can rebound quickly under the action of the elastic element 35, thus avoiding the membrane pores on the hydrophobic membrane 21 from being in a critical state of blockage.

[0051] The sleeve 6 is shaped like a bellows. When the sliding block 31 moves on the frame 2, it blocks the movable groove 33, thereby preventing the steam on the hot side of the reactor 1 from directly entering the cold side of the reactor 1 through the movable groove 33.

[0052] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A distillation apparatus for chemical pharmaceutical use, comprising a reaction vessel (1), wherein the bottom of the reaction vessel (1) is provided with an inlet (11) and an outlet (12); the interior of the reaction vessel (1) is provided with a frame (2), the four sides of the frame (2) are fixedly connected to the inner wall of the reaction vessel (1), and a hydrophobic membrane (21) is fixedly connected to the side of the frame (2) facing the inlet (11); the frame (2) divides the reaction vessel (1) into a hot side and a cold side, the side of the frame (2) facing the inlet (11) is the hot side, and the side of the frame (2) facing the outlet (12) is the cold side; Its features are: A spring bar (22) is fixedly connected to the side of the hydrophobic membrane (21) facing the inlet (11). The spring bar (22) is evenly distributed along the longitudinal axis of the frame (2). The frame (2) is provided with a movable mechanism (3) on both sides. The spring bar (22) cooperates with the movable mechanism (3) to make itself elastically deformed and thus clean the impurities adhering to the hydrophobic membrane (21). A movable frame (4) that slides up and down along the longitudinal axis of the frame (2) is slidably connected to the side of the frame (2) near the outlet (12). A partition plate (41) that is evenly distributed is fixedly connected to the longitudinal axis of the movable frame (4). The side of the partition plate (41) near the frame (2) is in contact with the side of the hydrophobic membrane (21) facing the outlet (12). A protrusion that is evenly distributed is fixedly connected to both sides of the movable frame (4). The protrusion cooperates with the movable mechanism (3) to make the elastic bar (22) undergo elastic deformation, so that the elastic bar (22) drives the hydrophobic membrane (21) to bulge towards the hot side of the reactor (1). A drive motor (5) is provided on the outer wall of the reactor (1). A rotating shaft (51) is fixedly connected to the output end of the drive motor (5). A cam (52) is fixedly connected to the end of the rotating shaft (51) away from the drive motor (5). The cam (52) is in contact with the bottom of the movable frame (4). The active mechanism (3) includes a sliding block (31), which is located at both ends of the elastic bar (22) and is slidably connected to the elastic bar (22). A compression piece (32) is fixedly installed at the end of the sliding block (31) that passes through the elastic bar (22) and is close to the inlet (11). The length of the sliding block (31) is greater than the length between the two sides of the frame (2). A movable groove (33) is provided on the frame (2), and a sliding block (31) is located inside the movable groove (33). A limiting groove (34) is provided inside the movable groove (33). An elastic element (35) is provided inside the limiting groove (34). One end of the elastic element (35) is ball-jointed with the sliding block (31), and the other end is ball-jointed with the top of the limiting groove (34). The elastic element (35) is a compression spring. The elastic element (35) can only move inside the limiting groove (34). The bottom of the sliding block (31) is provided with a groove (36), and a fixing block (37) is provided in the groove (36) and fixedly connected to the bottom of the movable groove (33). The connection point between the elastic element (35) and the sliding block (31) is located at one end of the groove (36) near the extrusion piece (32). The area of ​​the partition (41) on the movable frame (4) is larger than the area of ​​the hydrophobic membrane (21) when it protrudes towards the hot side of the reactor (1); when the hydrophobic membrane (21) protrudes towards the hot side of the reactor (1), the partition (41) on the movable frame (4) coincides with the protruding part of the hydrophobic membrane (21); A sleeve (6) is connected to the outer wall of the sliding block (31) near the extrusion plate (32). The other end of the sleeve is fixedly connected to the frame (2). The sleeve seals the movable groove (33).

2. The distillation equipment for chemical and pharmaceutical applications according to claim 1, characterized in that: The elastic force of the spring bar (22) is greater than the pressure on the hot side of the reactor (1) when the hydrophobic membrane (21) is blocked.

3. The distillation equipment for chemical and pharmaceutical applications according to claim 1, characterized in that: The protrusion on the movable frame (4) is located on the side of the sliding block (31) near the center line of the frame (2), and the shape of the side of the sliding block (31) near the center line of the frame (2) is arc-shaped.

Images