Rotator cuff patch containing exosomes and preparation method thereof

By preparing rotator cuff patches with core-shell nanofiber membrane structures containing exosomes, the problems of insufficient mechanical properties and low biocompatibility of existing rotator cuff patches are solved, and the rotator cuff repair effect is achieved with high strength and good biocompatibility.

CN116196478BActive Publication Date: 2025-08-29BEIJING INST OF TRAUMATOLOGY & ORTHOPEDICS +1
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Patent Information

Application Number
CN202310077942.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-01-17
Publication Date
2025-08-29
Estimated Expiration
2043-01-17

AI Technical Summary

Technical Problem

The existing rotator cuff patches have insufficient mechanical properties and low biocompatibility and biosafety, resulting in unsatisfactory repair results of rotator cuff tear.

Method used

The core-shell nanofiber membrane structure containing exosomes is adopted. The core layer is composed of exosomes and polymers. The shell layer is composed of polymer polymers and hexafluoroisopropanol. Rotor cuff patches are prepared through coaxial electrospinning technology to mimic the ultrastructure of the extracellular matrix.

Benefits of technology

The prepared rotator cuff patch has sufficient mechanical strength and elasticity, can guide tissue growth, promote healing, have good biocompatibility, slow release of exosomes, avoid sudden release, and meet the functional requirements of rotator cuff repair.

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Abstract

The present invention discloses a rotator cuff patch containing exosomes and a preparation method thereof. Nanofibers are prepared by coaxial electrospinning, which mimics the ultrastructure of the extracellular matrix. At the same time, the nanofiber structure is similar to rotator cuff tissue and can mimic rotator cuff tissue. Moreover, the nanofibers have sufficient mechanical strength and elasticity to guide tissue growth in the appropriate direction and have ideal biomedical functions. The core layer contains exosomes, which can promote the migration and fusion of osteoblasts and tendon cells, and has the effect of promoting tissue healing. At the same time, because the exosomes are encapsulated in the nanofiber core layer structure, they are released more slowly than ordinary blended nanofibers. Therefore, the core-shell structure can slow down the release of exosomes and avoid sudden release. The present invention combines the complementary advantages of high molecular polymers, extracellular vesicles (exosomes), and natural collagen in terms of composition and properties, and combines the biomimetic structure of nanofibers to prepare a biomimetic rotator cuff patch with a rotator cuff structure and promoted healing.
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