A continuous intraocular pressure monitoring sensor and method of measuring intraocular pressure

Abstract

The application discloses a continuous intraocular pressure monitoring sensor and an intraocular pressure measuring method, and relates to the technical field of medical devices, in particular to a continuous intraocular pressure monitoring sensor and an intraocular pressure measuring method. The continuous intraocular pressure monitoring sensor comprises an intraocular pressure strain sensing circuit and a wireless transmission circuit which are packaged in a corneal contact lens. The intraocular pressure strain sensing circuit is composed of a strain measurement resistor and a temperature compensation resistor, is used for monitoring changes in eyeball curvature caused by intraocular pressure changes and converting the changes into an electric signal. The strain measurement resistor is arranged in a circumferential direction for measuring strain. The temperature compensation resistor is arranged in a radial direction for measuring strain. Temperature compensation of the strain measurement resistor is realized by differentiating resistance value changes of the strain measurement resistor and the temperature compensation resistor. The wireless transmission circuit is connected with the strain measurement resistor and the temperature compensation resistor. The continuous intraocular pressure monitoring sensor can realize continuous and real-time monitoring of intraocular pressure of a patient without affecting normal vision of the patient, is simple to use, is convenient to carry, and makes the measurement result more accurate.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of contact lenses, and particularly relates to a continuous intraocular pressure monitoring sensor and an intraocular pressure measuring method. BACKGROUND

[0002] Glaucoma is the second leading cause of blindness worldwide, and can cause irreversible blindness in severe cases. Related studies have shown that controlling and reducing the intraocular pressure of patients is the only available method for treating glaucoma patients. During the treatment process, the intraocular pressure of patients needs to be detected to determine whether the treatment has taken effect. Since the intraocular pressure of patients is prone to fluctuate with the circadian rhythm, and the measurement of the intraocular pressure of patients is affected by the body posture of patients, the peak value of the intraocular pressure of patients usually occurs at night or in the morning, and long-term and continuous tracking is required to analyze the key intraocular pressure fluctuations. Therefore, continuous real-time monitoring of the intraocular pressure of patients is crucial to the treatment of patients.

[0003] Currently, the instruments used in clinics for measuring the intraocular pressure of patients mainly include non-contact tonometers, Goldmann applanation tonometers, and Icare rebound tonometers, etc. However, these instruments usually require well-trained clinicians, and cannot achieve continuous intraocular pressure detection. In addition, due to their large size, they are inconvenient to carry around, have limited measurement accuracy, and other shortcomings, making it difficult to collect key intraocular pressure fluctuations of patients. Therefore, it is urgent to develop a portable, high-precision, and continuous intraocular pressure monitoring device for patients, which is increasingly critical to the treatment of patients.

[0004] Although invasive sensors can perform continuous intraocular pressure monitoring, they require surgery and the implantation process is irreversible, making them unacceptable to most patients. Contact lenses are currently an ideal platform for close contact with the human eye and have been used as wearable devices for physiological measurements. In recent decades, contact lens IOP (intraocular pressure) sensors integrating LC resonant circuits, microfluidics, piezoresistive, and photonic crystal technologies have emerged. The wireless transmission methods of intraocular pressure data based on contact lens non-invasive sensors mainly include optical image comparison, LC resonant frequency measurement, and data transmission through integrated embedded chips. The optical image comparison method requires an optical reading device, and it cannot perform continuous real-time intraocular pressure monitoring. Capacitive and inductive sensors require measurement of resonant frequency to read signals, and require frequency or phase discriminators to read signals. The detection instrument is large in size, which is not conducive to patients to carry around, and it is difficult to achieve continuous monitoring of IOP in clinics.

[0005] Unlike optical and LC resonant sensors, the data transmission through the integrated embedded chip can be miniaturized, and the sensing mechanism is based on a resistive sensor. One prior art uses silver nanowires as a sensor while integrating a wireless circuit for non-invasive continuous intraocular pressure monitoring, which measures the change of the resistance of the silver nanowire sensor with the eyeball curvature to calculate the intraocular pressure, but it does not solve the problem of the influence of temperature on the silver nanowire sensor. Another prior art uses a serpentine silicon-based strain gauge as a sensor while integrating an NFC chip for wireless transmission, which uses the temperature sensor in the NFC chip to collect temperature data in real time, and combines the linear change of the resistance of the silicon-based strain gauge with temperature to correct the intraocular pressure in the collection program, but due to the low accuracy of the temperature sensor in the NFC chip, and the heating of the chip during use, accurate temperature data cannot be obtained, and there is still an error after correction. The continuous IOP monitoring sensor developed by Xu Jiandong et al. of Tsinghua University uses few-layer graphene combined with a Wheatstone bridge, and the Wheatstone bridge circuit can avoid the influence of temperature, but due to the need to arrange two fixed-value resistors and two measuring resistors at the same time, and the need to ensure the balance of the initial bridge, plus the limited space of the contact lens, it causes many inconveniences to the design of the wireless transmission circuit of the integrated embedded chip.

[0006] Therefore, in the prior art, the sensing and sensing method for continuous intraocular pressure monitoring through a resistive sensor cannot solve the problem of the influence of temperature change on the measurement result. SUMMARY

[0007] In view of the urgent need for continuous and real-time intraocular pressure monitoring of glaucoma patients by the current intraocular pressure monitoring equipment, the present application provides a continuous intraocular pressure monitoring sensor and an intraocular pressure measurement method, which embeds an intraocular pressure strain sensing circuit and a wireless transmission circuit into a corneal contact lens, and can continuously and real-time monitor the intraocular pressure of the patient without affecting the normal vision of the patient, is simple to use and convenient to carry, can more simply avoid errors caused by the influence of environmental temperature on the resistive sensor, and makes the measurement result more accurate when the patient wears it.

[0008] The present application adopts the following specific technical solutions:

[0009] The present application provides a continuous intraocular pressure monitoring sensor, which comprises a flexible corneal contact lens and an intraocular pressure strain sensing circuit and a wireless transmission circuit packaged in the corneal contact lens.

[0010] The corneal contact lens is in a spherical crown structure, and is used to be worn on the eyeball of the patient to closely fit the cornea of the eye, so as to ensure the accuracy of the sensing of the intraocular pressure strain sensing circuit.

[0011] The intraocular pressure strain sensing circuit is composed of a strain measurement resistance and a temperature compensation resistance, and is used for monitoring the change of eyeball curvature caused by the change of intraocular pressure and converting the change into an electrical signal; the strain measurement resistance is arranged along the circumferential direction of the strain measurement direction; the temperature compensation resistance is arranged along the radial direction of the strain measurement direction; the temperature compensation of the strain measurement resistance is realized by differentiating the resistance value change of the strain measurement resistance and the temperature compensation resistance;

[0012] The wireless transmission circuit is connected with the strain measurement resistance and the temperature compensation resistance, and is used for collecting and processing the electrical signals obtained by the strain measurement resistance and the temperature compensation resistance, and transmitting data to an external receiving device.

[0013] Further, the wireless transmission circuit includes an LC energy supply module, a conductive circuit, a fixed value resistance and an ASIC chip.

[0014] The LC energy supply module is composed of an antenna coil and a resonance capacitor.

[0015] The conductive circuit is used to connect the antenna coil, the resonance capacitor, the ASIC chip, the fixed value resistance, the strain measurement resistance and the temperature compensation resistance.

[0016] Further, the ASIC chip includes a radio frequency module, a power management module and a digital-to-analog conversion module.

[0017] The power management module is connected with the strain measurement resistance, the temperature compensation resistance and the fixed value resistance, and is used for voltage stabilization and distribution.

[0018] The digital-to-analog conversion module is connected with the strain measurement resistance and the temperature compensation resistance, and is used for converting an analog signal into a digital signal.

[0019] The digital signal sending end of the digital-to-analog conversion module is connected with the radio frequency module, and the digital signal is transmitted to an external receiving device through the radio frequency module.

[0020] Further, the resistance value of the fixed value resistance, the resistance value of the strain measurement resistance and the resistance value of the temperature compensation resistance are all equal.

[0021] The ASIC chip calculates the resistance value of the strain measurement resistance by comparing the voltage between the fixed value resistance and the strain measurement resistance, and calculates the resistance value of the temperature compensation resistance by comparing the voltage between the fixed value resistance and the temperature compensation resistance.

[0022] Further, the diameter of the antenna coil is greater than the diameter of the pupil of the patient.

[0023] The antenna coil is made of copper or liquid metal.

[0024] Further, the antenna coil is made of multiple inductance coils in a spiral structure, and is separated from the strain measurement resistor and the temperature compensation resistor in the form of a multi-layer circuit.

[0025] The antenna coil is molded and encapsulated close to the air layer.

[0026] Further, the contact lens is made of a base of a high light transmission material that is biocompatible, safe and elastic.

[0027] The intraocular pressure strain sensing circuit and the wireless transmission circuit are prepared on the base by a microelectronic manufacturing process.

[0028] Further, the contact lens is made of PDMS (polydimethylsiloxane) or Parylene C (poly chlorinated p-xylene).

[0029] The conductive circuit is made of liquid metal or copper.

[0030] Further, the strain measurement resistor and the temperature compensation resistor are both made of nanowire material or graphene material, and are both continuous serpentine shapes.

[0031] Further, the external receiving device includes a data acquisition device and a terminal device in signal connection with the data acquisition device.

[0032] The terminal device is used to display the intraocular pressure value.

[0033] In addition, the present application also provides an intraocular pressure measurement method, which comprises the following steps:

[0034] An initial intraocular pressure value IOP0 of the patient is measured by an ophthalmotonometer, and the continuous intraocular pressure monitoring sensor is worn on the eyeball of the patient, and the resistance value R of the strain measurement resistor and the resistance value R of the temperature compensation resistor are obtained by the wireless transmission circuit. a0 b0 ;

[0035] When the intraocular pressure changes, the intraocular pressure IOP1 of the patient at this time is measured again by the ophthalmotonometer, and the resistance value R of the strain measurement resistor and the resistance value R of the temperature compensation resistor at this time are obtained by the wireless transmission circuit. a1 b1 ;

[0036] ​​The patient is continuously monitored by the contact lens sensor, when the resistance R of the strain measurement resistance and the resistance R of the temperature compensation resistance are changed, at this time the intraocular pressure IOP is: a2 b2

[0037]

[0038] Beneficial effects:

[0039] The continuous intraocular pressure monitoring sensor of the application is worn on the eyeball of the patient by a flexible corneal contact lens, and the intraocular pressure strain sensing circuit and the wireless transmission circuit are packaged in the corneal contact lens, the intraocular pressure strain sensing circuit monitors the change of the eyeball curvature caused by the change of the intraocular pressure and converts it into an electrical signal through the strain measurement resistance and the temperature compensation resistance, the strain measurement resistance is arranged along the circumferential direction of the strain measurement direction, and the temperature compensation resistance is arranged along the radial direction of the strain measurement direction, and the temperature compensation of the strain measurement resistance is realized by differentiating the resistance value change of the strain measurement resistance and the temperature compensation resistance; the wireless transmission circuit is used for collecting and processing the electrical signals obtained by the strain measurement resistance and the temperature compensation resistance, and transmitting the data to the external receiving device; the continuous intraocular pressure monitoring sensor of the application combines the corneal deformation characteristics, that is, the deformation of the cornea is mainly circumferential deformation, and the radial deformation is not obvious, the change of the eyeball curvature can be well perceived by the circumferentially arranged strain measurement resistance and converted into an electrical signal, and the temperature compensation resistance arranged along the radial direction of the strain measurement direction is less affected by the change of the eyeball curvature, and the resistance value change is mainly caused by the temperature change in the external environment, and the temperature compensation of the strain measurement resistance is realized by differentiating the resistance value change of the strain measurement resistance and the temperature compensation resistance; therefore, the intraocular pressure strain sensing circuit and the wireless transmission circuit are embedded in the corneal contact lens, the continuous real-time monitoring of the intraocular pressure of the patient can be realized without affecting the normal vision of the patient, the use is simple and convenient to carry, the method for temperature compensation of the resistance strain gauge is realized, and it is more accurate and simple; at the same time, the error of the resistance sensor caused by the influence of the environmental temperature can be more simply avoided, so that the measurement result of the patient when wearing is more accurate. BRIEF DESCRIPTION OF DRAWINGS

[0040] Figure 1 It is a structure schematic view of the continuous intraocular pressure monitoring sensor of the application;

[0041] Figure 2 It is a sectional view of A1-A2 section in Figure 1

[0042] Figure 3 It is a working principle schematic view of the continuous intraocular pressure monitoring sensor of the application.

[0043] ​​​Wherein, 1 - a contact lens, 2 - an antenna coil, 3 - a conductive line, 4 - a strain measurement resistance, 5 - a temperature compensation resistance, 6 - a constant resistance, 7 - an ASIC chip, 8 - a central optical zone, 9 - a resonance capacitor, 10 - an eyeball, 11 - a data acquisition device, 12 - a terminal device, 13 - an intraocular pressure strain sensing circuit DETAILED DESCRIPTION

[0044] The application will be described in detail below with reference to the accompanying drawings and examples.

[0045] Example 1

[0046] This embodiment provides a continuous intraocular pressure monitoring sensor, as shown in Figure 1 、 Figure 2 and Figure 3 , the continuous intraocular pressure monitoring sensor comprises a flexible contact lens 1 and an intraocular pressure strain sensing circuit 13 and a wireless transmission circuit packaged in the contact lens 1.

[0047] The contact lens 1 is a spherical cap structure matched with the shape of the eyeball 10, which is used to be worn on the eyeball 10 of the patient to closely fit with the cornea of the eye, ensuring the accuracy of the intraocular pressure strain sensing circuit 13.

[0048] The intraocular pressure strain sensing circuit 13 is composed of a strain measurement resistance 4 and a temperature compensation resistance 5, which is used to monitor the change of the curvature of the eyeball 10 caused by the change of the intraocular pressure and convert it into an electrical signal; the strain measurement resistance 4 is arranged along the circumferential direction of the strain measurement; the temperature compensation resistance 5 is arranged along the radial direction of the strain measurement; the temperature compensation of the strain measurement resistance 4 is realized by differentiating the resistance value change of the strain measurement resistance 4 and the temperature compensation resistance 5; the strain measurement resistance 4 and the temperature compensation resistance 5 are both made of nanowire material or graphene material, and both are continuous serpentine shape.

[0049] The wireless transmission circuit is connected with the strain measurement resistance 4 and the temperature compensation resistance 5, which is used to collect and process the electrical signal obtained by the strain measurement resistance 4 and the temperature compensation resistance 5, and transmit the data to the external receiving device; the external receiving device includes a data acquisition device 11 and a terminal device 12 connected with the data acquisition device 11; the terminal device 12 is used to display the intraocular pressure value, so as to display the intraocular pressure change value.

[0050] The continuous intraocular pressure monitoring sensor is worn on the eyeball 10 of the patient by the flexible corneal contact lens 1, and the intraocular pressure strain sensing circuit 13 and the wireless transmission circuit are embedded in the corneal contact lens 1, the intraocular pressure strain sensing circuit 13 monitors the change of the curvature of the eyeball 10 caused by the change of the intraocular pressure and converts it into an electrical signal through the strain measurement resistance 4 and the temperature compensation resistance 5, the strain measurement resistance 4 is arranged in the circumferential direction of the strain measurement direction, the temperature compensation resistance 5 is arranged in the radial direction of the strain measurement direction, and the temperature compensation of the strain measurement resistance 4 is realized by differentiating the resistance value change of the strain measurement resistance 4 and the temperature compensation resistance 5; the wireless transmission circuit is used for collecting and processing the electrical signals obtained by the strain measurement resistance 4 and the temperature compensation resistance 5, and transmitting the data to the external receiving device; the continuous intraocular pressure monitoring sensor of the application combines the corneal deformation characteristics, that is, the deformation of the cornea is mainly circumferential deformation, and the radial deformation is not obvious, the strain measurement resistance 4 arranged in the circumferential direction can well perceive the change of the curvature of the eyeball 10 and convert it into an electrical signal, and the temperature compensation resistance 5 arranged in the radial direction of the strain measurement direction is less affected by the change of the curvature of the eyeball 10, and the resistance value change is mainly caused by the temperature change in the external environment, and the temperature compensation of the strain measurement resistance 4 is realized by differentiating the resistance value change of the strain measurement resistance 4 and the temperature compensation resistance 5; therefore, the intraocular pressure strain sensing circuit 13 and the wireless transmission circuit are embedded in the corneal contact lens 1, the continuous real-time monitoring of the intraocular pressure of the patient can be realized without affecting the normal vision of the patient, the use is simple and can be carried conveniently, the method for temperature compensation of the resistance strain gauge is realized, and it is more accurate and simple; at the same time, the resistance sensor can be more simply avoided from being affected by the environmental temperature to generate errors, so that the measurement result of the patient when wearing is more accurate.

[0051] In a specific embodiment, the wireless transmission circuit includes an LC power supply module, a conductive circuit 3, a constant resistance 6 and an ASIC chip 7.

[0052] The LC power supply module is composed of the antenna coil 2 and the resonant capacitor 9; the diameter of the antenna coil 2 is greater than the diameter of the pupil of the patient; the antenna coil 2 is made of copper or liquid metal; the antenna coil 2 is composed of multiple inductance coils in a spiral structure, and is separated from the strain measurement resistor 4 and the temperature compensation resistor 5 in the form of a multi-layer circuit; the antenna coil 2 is molded and packaged close to the air layer; since the antenna coil 2 is composed of multiple inductance coils in a spiral structure, it can meet the efficient transmission of energy; the antenna coil 2 is separated from the strain measurement resistor 4 and the temperature compensation resistor 5 in the form of a multi-layer circuit, which can avoid the influence of the antenna coil 2 on the intraocular pressure strain sensing circuit 13; since the diameter of the antenna coil 2 is greater than the diameter of the pupil of the patient, the antenna coil 2 can be outside the pupil, ensuring the light transmission of the central optical zone 8 of the corneal contact lens 1 and avoiding the antenna coil 2 from blocking the patient's line of sight;

[0053] The conductive circuit 3 is used to connect the antenna coil 2, the resonant capacitor 9, the ASIC chip 7, the constant resistor 6, the strain measurement resistor 4 and the temperature compensation resistor 5; the conductive circuit 3 can be made of liquid metal or copper; the conductive circuit 3 can be prepared on the substrate forming the corneal contact lens 1 by microelectronic technology, for circuit connection between the components;

[0054] The ASIC chip 7 includes a radio frequency module, a power management module and a digital-to-analog conversion module; the power management module is connected with the strain measurement resistor 4, the temperature compensation resistor 5 and the constant resistor 6 for voltage stabilization and distribution; the digital-to-analog conversion module is connected with the strain measurement resistor 4 and the temperature compensation resistor 5 for converting analog signals into digital signals; the digital signal sending end of the digital-to-analog conversion module is connected with the radio frequency module to transmit digital signals to the external receiving device through the radio frequency module.

[0055] Further, the resistance values of the constant resistor 6, the strain measurement resistor 4 and the temperature compensation resistor 5 are equal; the resistance values of the two serpentine strain resistors in the intraocular pressure strain sensing circuit 13 can be calculated by comparing the voltages across the constant resistor 6 and the two serpentine strain resistors when the wireless transmission circuit is working; if there is no constant resistor with the same resistance value, a technical solution with similar resistance values of the constant resistor 6, the strain measurement resistor 4 and the temperature compensation resistor 5 can also be used; the purpose of equal or similar resistance values is to improve the accuracy of measuring the resistance values of the two serpentine strain resistors, the strain measurement resistor 4 and the temperature compensation resistor 5;

[0056] The ASIC chip 7 calculates the resistance value of the strain measurement resistor 4 by comparing the voltages across the constant resistor 6 and the strain measurement resistor 4, and calculates the resistance value of the temperature compensation resistor 5 by comparing the voltages across the constant resistor 6 and the temperature compensation resistor 5.

[0057] In the continuous intraocular pressure monitoring sensor, the corneal contact lens 1 is made of a base of a high-transparency material with biocompatibility and safety and elasticity, which is used to encapsulate the intraocular pressure strain sensing circuit 13 and the wireless transmission circuit to enable stable operation for a long time in a closed environment; the corneal contact lens 1 is made of PDMS or Parylene C; and the intraocular pressure strain sensing circuit 13 and the wireless transmission circuit are prepared on the base through a microelectronic manufacturing process.

[0058] Embodiment two

[0059] The embodiment provides an intraocular pressure measurement method, which is measured by using the continuous intraocular pressure monitoring sensor in the above embodiment, and specifically includes the following steps:

[0060] An initial intraocular pressure value IOP0 of a patient is measured by using a tonometer, and the continuous intraocular pressure monitoring sensor in the above embodiment is worn on the eyeball 10 of the patient, so that the resistance value R of the strain measurement resistor 4 and the resistance value R of the temperature compensation resistor 5 are obtained through the wireless transmission circuit; a0 b0 When the initial intraocular pressure value of the patient is measured by using the tonometer, the measurement can be performed according to a clinical standard scheme;

[0061] When the intraocular pressure changes after a period of time, the intraocular pressure IOP1 of the patient at this time is measured again by using the tonometer, and the resistance value R of the strain measurement resistor 4 and the resistance value R of the temperature compensation resistor 5 at this time are obtained through the wireless transmission circuit; a1 b1 When the intraocular pressure of the patient is measured again by using the tonometer, the same scheme as the initial measurement is used, that is, the measurement can be performed again according to the clinical standard scheme;

[0062] The patient is continuously monitored by using the contact lens sensor, and when the resistance value R of the strain measurement resistor 4 and the resistance value R of the temperature compensation resistor 5 are a2 b2 The intraocular pressure IOP at this time is:

[0063]

[0064] By using the above intraocular pressure measurement method and the continuous intraocular pressure monitoring sensor in the above embodiment, the intraocular pressure of the patient can be continuously and real-timely monitored without affecting the normal vision of the patient, and the problem that the existing intraocular pressure monitoring equipment cannot meet the urgent needs of continuous and real-time intraocular pressure monitoring of glaucoma patients is solved.

[0065] To sum up, the above is only a preferred embodiment of the present application, and is not used to limit the protection scope of the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.​​​

Claims

1. A continuous intraocular pressure monitoring sensor, characterized by, The application relates to an intraocular pressure sensing contact lens, which comprises a flexible contact lens and intraocular pressure sensing circuit and wireless transmission circuit encapsulated in the contact lens. The contact lens is a spherical crown structure, which is used for being worn on the eyeball of a patient to closely contact with the cornea of the eye, so as to ensure the accuracy of the intraocular pressure sensing circuit. The intraocular pressure sensing circuit is composed of a strain measurement resistance and a temperature compensation resistance, which is used for monitoring the change of the eyeball curvature caused by the change of the intraocular pressure and converting the change into an electric signal. The strain measurement resistance is arranged along the circumferential direction of the strain measurement direction, and the temperature compensation resistance is arranged along the radial direction of the strain measurement direction; the temperature compensation of the strain measurement resistance is realized by differentiating the resistance value change of the strain measurement resistance and the temperature compensation resistance. The wireless transmission circuit is connected with the strain measurement resistance and the temperature compensation resistance, which is used for collecting and processing the electric signal obtained by the strain measurement resistance and the temperature compensation resistance, and transmitting the data to an external receiving device.

2. The continuous intraocular pressure monitoring sensor of claim 1, wherein, The wireless transmission circuit comprises an LC energy supply module, a conductive circuit, a constant resistance and an ASIC chip. The LC energy supply module is composed of an antenna coil and a resonance capacitor. The conductive circuit is used for connecting the antenna coil, the resonance capacitor, the ASIC chip, the constant resistance, the strain measurement resistance and the temperature compensation resistance.

3. The continuous intraocular pressure monitoring sensor of claim 2, wherein, The ASIC chip comprises a radio frequency module, a power management module and a digital-analog conversion module. The power management module is connected with the strain measurement resistance, the temperature compensation resistance and the constant resistance, which is used for stabilizing and distributing voltage. The digital-analog conversion module is connected with the strain measurement resistance and the temperature compensation resistance, which is used for converting an analog signal into a digital signal. The digital signal sending end of the digital-analog conversion module is connected with the radio frequency module, and the digital signal is transmitted to the external receiving device through the radio frequency module.

4. The continuous intraocular pressure monitoring sensor of claim 3, wherein, The resistance value of the constant resistance, the resistance value of the strain measurement resistance and the resistance value of the temperature compensation resistance are equal. The ASIC chip calculates the resistance value of the strain measurement resistance by comparing the voltage between the constant resistance and the strain measurement resistance, and calculates the resistance value of the temperature compensation resistance by comparing the voltage between the constant resistance and the temperature compensation resistance.

5. The continuous intraocular pressure monitoring sensor of claim 2, wherein, The diameter of the antenna coil is greater than the diameter of the pupil of the patient. The antenna coil is made of copper or liquid metal.

6. The continuous intraocular pressure monitoring sensor of claim 2, wherein, The antenna coil is composed of a plurality of inductance coils in a spiral structure, and is separated from the strain measurement resistance and the temperature compensation resistance in the form of a multilayer circuit. The antenna coil is molded and encapsulated in a layer close to air.

7. The continuous intraocular pressure monitoring sensor of claim 2, wherein, The contact lens is made of a high light transmission material base with biocompatibility and safety and elasticity. The intraocular pressure sensing circuit and the wireless transmission circuit are prepared on the base through a microelectronic manufacturing process.

8. The continuous intraocular pressure monitoring sensor of claim 7, wherein, The contact lens is made of PDMS or Parylene C. The conductive circuit is made of liquid metal or copper.

9. The continuous intraocular pressure monitoring sensor of claim 1, wherein, The strain measurement resistance and the temperature compensation resistance are both made of nanowire material or graphene material and are both continuous serpentine shapes; The external receiving device comprises a data acquisition device and a terminal device in signal connection with the data acquisition device; The terminal device is used for displaying the intraocular pressure value.

10. A method of measuring intraocular pressure, characterized by, comprising the steps of: An initial intraocular pressure value IOP0 of the patient is measured by means of a tonometer while the continuous intraocular pressure monitoring sensor according to any one of claims 1 to 9 is worn on the eyeball of the patient, and the resistance value R of the strain measurement resistor is obtained by means of the wireless transmission circuit a0 and the resistance value R of the temperature compensation resistor b0 ; When the intraocular pressure changes, the patient's current intraocular pressure IOP1 is measured again by the tonometer, and the resistance value R of the strain measurement resistor at this time is obtained through the wireless transmission circuit a1 and the resistance value R of the temperature compensation resistor b1 ; Continuous intraocular pressure monitoring of a patient by means of a contact lens sensor, when the resistance R a2 of a strain gauge resistance and the resistance R b2 of a temperature compensation resistance are measured, at which time the intraocular pressure IOP is:

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