A vibrating mechanism

Abstract

The application provides a vibrating mechanism, a sample carrier is used for loading a solution; a first swing connecting part and a second swing connecting part are connected with the sample carrier, the first swing connecting part and the second swing connecting part swing around the same swing shaft; an eccentric wheel is in transmission connection with a rotary driving part, a connecting rod is connected with the eccentric wheel and is arranged eccentrically relative to the rotation center of the eccentric wheel, the first swing connecting part is provided with a sliding groove, a sliding connecting piece is slidably arranged in the sliding groove, the sliding connecting piece is connected with the connecting rod, and the distribution direction of the sliding groove is tangent to the swing radial direction of the first swing connecting part. The sample carrier is driven to reciprocate by the eccentric structure, so that the vibration effect is achieved, the solution is rapidly mixed, and the reaction force borne by the transmission structure and the output shaft of the rotary driving part is obviously reduced in the setting mode that the sliding groove is tangent to the swing radial direction, therefore, the cyclic stress can be greatly reduced, and the fatigue life and the reliability of the mechanism are effectively improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of detection instruments, in particular to a shaking mechanism. BACKGROUND

[0002] In biological extraction, different types of extraction reagents can be used to extract samples such as animal and plant tissues, blood and body fluids. The sample types are suitable for serum, plasma, throat swabs, anal swabs, feces, genital tract secretions, exfoliated cells, urine, sputum, and nucleic acid extraction and purification. Obviously, different reagents need to be added to the sample for different tests, and mixing, shaking and other operations are required after adding the reagents to ensure that the reagents and the sample are fully mixed.

[0003] In the prior art, there are mainly two ways to mix solutions. One is to use a stirring paddle to stir the liquid to achieve uniform mixing. This mixing method is not suitable for medical tests because the liquid sample is usually contained in a test tube with a small diameter, and it is not easy to find a stirring paddle with a suitable size. Moreover, the stirring paddle is easy to cause the liquid sample to overflow or the test tube to be damaged during high-speed rotation. The second is to use a shaking method for mixing. This mixing method is commonly used in medical tests, but most of the current shaking is in the vertical direction. This requires that the test tube must be sealed to prevent spilling during shaking.

[0004] In the prior art, there are devices that mix solutions by oscillating (shaking). However, such devices usually require high-frequency shaking drive and transmission, and the transmission structure is subjected to large cyclic stress, resulting in reduced fatigue life and frequent replacement and maintenance. SUMMARY

[0005] The purpose of the present application is to provide a mechanism that can complete reagent sample mixing, is suitable for high-frequency shaking, and has better reliability and service life.

[0006] To achieve the above purpose, the present application provides a shaking mechanism, comprising a sample carrier, a rotary drive part, an eccentric wheel, a connecting rod, a first oscillating connecting part and a second oscillating connecting part.

[0007] The sample carrier is used to load the solution.

[0008] The first oscillating connecting part and the second oscillating connecting part are connected to the sample carrier, and the first oscillating connecting part and the second oscillating connecting part oscillate around the same oscillating shaft.

[0009] The eccentric wheel is in transmission connection with the rotary driving part, the connecting rod is connected with the eccentric wheel and is arranged eccentrically relative to the rotation center of the eccentric wheel, the first swing connecting part is provided with a sliding groove, a sliding connecting piece is slidably arranged in the sliding groove, the sliding connecting piece is connected with the connecting rod, and the distribution direction of the sliding groove is tangent to the swing direction of the first swing connecting part.

[0010] Further, the first swing connecting part is a first bearing seat, the second swing connecting part is a second bearing seat, and the sliding connecting piece is a bearing.

[0011] Further, the second bearing seat is provided with a connecting hole, and a connecting screw is arranged in the connecting hole and fixed to the position of the swing shaft.

[0012] Further, the driving mode of the rotary driving part includes continuous rotation output and positive and negative period rotation output.

[0013] Further, the rotary driving part is an electric motor.

[0014] Further, the vibration mechanism further comprises a position sensor for sensing the swing of the sample carrier.

[0015] Further, the position sensor comprises a photoelectric switch and a light blocking piece, the photoelectric switch is fixedly arranged, and the light blocking piece swings with the sample carrier.

[0016] Further, the sample carrier comprises a deep well plate and a fixed tray.

[0017] The fixed tray is provided with a top plate, a top pressing mounting groove, a top pressing mounting plate and a top pressing spring, the top plate is movably connected with the top pressing mounting groove, the top pressing mounting plate is detachably connected with the fixed tray, the top pressing spring is arranged between the top plate and the top pressing mounting plate, and the top plate is in contact with the side surface of the deep well plate.

[0018] Further, the top plate is formed with an inverted inclined surface for guiding the mounting of the deep well plate.

[0019] Further, the fixed tray is further provided with a heating assembly for heating a solution.

[0020] The above-mentioned scheme of the present application has the following advantages:

[0021] The vibrating mechanism provided by the application drives the eccentric wheel to do circular motion through the motor, the eccentric connecting rod connected with the eccentric wheel drives the sample carrier to swing back and forth, so as to achieve the vibrating effect and make the solution complete rapid mixing, under the setting mode that the chute is tangent to the swing radial, the reaction force borne by the output shaft of the transmission structure and the rotary driving part is obviously reduced, so the cyclic stress can be greatly reduced, the fatigue life and reliability of the mechanism are effectively improved, meanwhile, the photoelectric switch is adopted to detect the signal passed by the sample carrier, and the motor is controlled to rotate according to the signal, so the regular high-frequency vibration is realized, the uniformity of solution mixing is improved, in addition, the stability of the sample carrier and the solution heating and mixing are ensured, and the application is suitable for the pipeline type online operation.

[0022] Other beneficial effects of the application will be described in detail in the following specific embodiment part. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 It is the overall structure schematic diagram of the application;

[0024] Figure 2 It is the vibrating driving assembly schematic diagram of the application;

[0025] Figure 3 It is another vibrating driving assembly schematic diagram of the application;

[0026] Figure 4 It is the swing process schematic diagram (first state) of the application;

[0027] Figure 5 It is the swing process schematic diagram (second state) of the application;

[0028] Figure 6 It is the swing position schematic diagram of the application;

[0029] Figure 7 It is the sample carrier schematic diagram of the application;

[0030] Figure 8 It is the top pressure part explosion schematic diagram of the application;

[0031] Figure 9 It is the top plate inverted slope structure schematic diagram of the application.

[0032]

Explanation of reference signs

[0033] 100, sample carrier; 110, carrier assembly; 111, fixed tray; 112, top plate; 113, top pressing spring; 114, top pressing mounting plate; 115, top pressing mounting groove; 116, bolt through hole; 117, reverse bevel; 120, sample container; 121, deep well plate; 200, vibration driving assembly; 201, eccentric wheel; 202, connecting rod; 203, first bearing seat; 204, second bearing seat; 205, sliding groove; 206, bearing; 207, connecting screw; 208, rotating bracket; 209, motor; 300, position sensor; 301, photoelectric switch; 302, light barrier; 400, bottom plate. DETAILED DESCRIPTION

[0034] In order to make the technical problems solved by the present application, technical solutions and advantages clearer, the following will be described in detail with reference to the drawings and specific embodiments. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application. In addition, the technical features involved in the different implementation manners of the present application described below can be combined with each other as long as there is no conflict.

[0035] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second", "third" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0036] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be a locking connection, or a detachable connection, or an integral connection; it can be a mechanical connection, or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, or the internal communication of two elements. For a person of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0037] As Figures 1-9As shown, the embodiment of the present application provides a vibration mechanism, which comprises a sample carrier 100 and a vibration driving assembly 200. The sample carrier 100 comprises a carrier assembly 110 and a sample container 120, the sample container 120 is used to load a mixed solution of samples and reagents, and the carrier assembly 110 is used to support and fix the sample container 120. The vibration driving assembly 200 drives the whole sample carrier 100 to vibrate at a high frequency, so that the samples and reagents are fully mixed.

[0038] In the embodiment, a deep well plate 121 is taken as an example, which is a common sample container 120 in sample detection and has multiple rows of deep wells. Different mixed solutions can be loaded in each row of deep wells, and each row of deep wells comprises an equal number of deep wells, i.e., the deep wells are arranged in an array. It should be noted that the depth of the deep well is usually more than 40 mm, the amount of liquid loaded in each deep well is small, and the amplitude of the vibration driving assembly 200 driving the deep well plate 121 to vibrate at a high frequency is 0-30 degrees, so the liquid in the deep well will not splash out.

[0039] Please refer to Figure 2 , Figure 3 In the embodiment, the vibration driving assembly 200 comprises a rotary driving part and an eccentric transmission part. The eccentric transmission part comprises an eccentric wheel 201, one end of the eccentric wheel 201 is fixedly connected with an output shaft of the rotary driving part, and the other end is provided with a connecting rod 202. The connecting rod 202 is not on the same center line as the output shaft of the rotary driving part, so that the connecting rod 202 can rotate eccentrically under the driving of the rotary driving part.

[0040] Correspondingly, the carrier assembly 110 is connected with a first bearing seat 203 and a second bearing seat 204. The first bearing seat 203 is provided with a sliding groove 205, and a bearing 206 is slidably arranged in the sliding groove 205. The bearing 206 is fixedly connected with the connecting rod 202. The second bearing seat 204 is rotatably connected with a rotary support 208 through a connecting screw 207 (the connecting screw 207 is a special-shaped screw with a smooth rotary support surface). The rotary support 208 is fixedly arranged to rotatably support the whole sample carrier 100.

[0041] Of course, in other embodiments, the transmission mode of the bearing 206 can be replaced. For example, the size of the sliding groove 205 can be reduced, and a pin shaft connection mode can be used. The two ends of the pin shaft are located outside the sliding groove 205, and the pin shaft is limited in the sliding groove 205 by a nut or the like. The end of the connecting rod 202 is rotatably connected with the pin shaft.

[0042] Please refer to Figure 4 , Figure 5, the rotating driving part drives the eccentric wheel 201 to rotate, since the connecting rod 202 and the output shaft of the rotating driving part are not on the same center line, when the connecting rod 202 rotates, the bearing 206 slides in the sliding groove 205, and the second bearing seat 204 is rotationally connected with the rotating support 208, thereby the first bearing seat 203 and the second bearing seat 204 drive the sample carrier 100 to rotate, realizing the reciprocating swing of the deep hole plate 121, and forming the high-frequency vibration effect.

[0043] Please refer to Figure 6 , based on the setting of the second bearing seat 204, the whole of the sample carrier 100, the first bearing seat 203 and the second bearing seat 204 will swing around the set swing axis, i.e. the axis of the connecting screw 207 rotationally connected with the second bearing seat 204. Meanwhile, the whole has a swing symmetry plane, when the center line of the whole is in the swing symmetry plane, it is at the 0-degree position of the swing.

[0044] In the embodiment, the distribution direction of the sliding groove 205 is perpendicular to the swing radius of the sample carrier 100, so when the whole is at the 0-degree position of the swing, the sliding groove 205 is perpendicular to the swing symmetry plane. When the rotating driving part drives the swing, the whole starts to swing from the 0-degree position, at this time, the connecting rod 202 and the bearing 206 are also at the 0-degree position, i.e. in the swing symmetry plane, so the instantaneous speed direction of the bearing 206 is perpendicular to the swing radius, i.e. perpendicular to the swing symmetry plane.

[0045] Based on the direction setting of the sliding groove 205, the reaction force of the inner wall of the sliding groove 205 on the bearing 206 is zero, during the continuous rotation of the connecting rod 202 and the bearing 206 around the output shaft of the rotating driving part, the bearing 206 will gradually slide and generate a force with the inner wall of the sliding groove 205, driving the sliding groove 205 and the like to rotate around the swing axis and swing.

[0046] It can be understood that since the swing angle of the vibration mechanism is only 0-30 degrees, the deflection angle of the sliding groove 205 and the like is also 0-30 degrees, which always only receives a small force of the bearing 206, compared with the setting mode that the distribution direction of the sliding groove 205 is consistent with the swing radius of the sample carrier 100 (in this mode, the reaction force of the inner wall of the sliding groove 205 is the largest at the 0-degree position), the reaction force of the transmission structure of the bearing 206, the connecting rod 202, the eccentric wheel 201 and the output shaft of the rotating driving part is obviously reduced, so the cyclic stress can be greatly reduced, effectively improving the fatigue life and reliability of the mechanism.

[0047] Please refer to Figure 3In this embodiment, the rotation drive unit uses a motor 209 for rotational drive. It is understood that the motor 209 can generate oscillation through both continuous rotational output and periodic rotational output; the periodic rotational output method is preferred. Preferably, a position sensor 300 is also provided to sense the oscillation of the sample carrier 100. The position sensor 300 determines the oscillation frequency of the sample carrier 100, and the corresponding motor 209 controller outputs a corresponding pulse frequency to control the oscillation frequency of the deep-hole plate 121.

[0048] Specifically, in this embodiment, the position sensor 300 can be in the form of a photoelectric switch 301, and a light-blocking plate 302 is provided on the first bearing seat 203 or the second bearing seat 204. When the light-blocking plate 302 passes the photoelectric switch 301 once, it outputs a signal. After receiving the signal, the photoelectric switch 301 records the signal and outputs a corresponding signal, thereby controlling the motor 209 to change its rotation direction, driving the deep hole plate 121 to swing back and forth, generating high-frequency vibration.

[0049] Meanwhile, the positions of photoelectric switch 301 and / or light-blocking plate 302 can be adjusted so that when the first bearing seat 203 or the second bearing seat 204 swings to different angles, the photoelectric switch 301 can detect it, thereby controlling the motor 209 to change the direction of rotation, thereby adjusting the swing angle (amplitude) of the mechanism.

[0050] In this embodiment, the motor 209, position sensor 300, rotating bracket 208, etc. are all mounted on the base plate 400, and the vibration mechanism is installed as a whole through the base plate 400.

[0051] In use, the motor 209 drives the eccentric wheel 201 to rotate. The eccentric connecting rod 202 connected to the eccentric wheel 201 drives the bearing 206 to slide in the groove 205, thereby causing the sample carrier 100 to swing back and forth to achieve a vibration effect, so as to complete the rapid mixing of the solution. Furthermore, a photoelectric switch 301 is used to detect the signal of the sample carrier 100 passing by, and then the motor 209 is controlled to rotate forward and reverse according to the signal, so as to realize the regular high-frequency vibration of the deep hole plate 121, which improves the uniformity of solution mixing.

[0052] Please refer to it again. Figure 7 , Figure 8 In this embodiment, the carrier assembly 110 includes a fixed tray 111. A first bearing seat 203 and a second bearing seat 204 are mounted on the lower surface of the fixed tray 111, and the upper surface of the fixed tray 111 is used to place the deep hole plate 121. At the same time, the fixed tray 111 is also provided with a pressing part for pressing the deep hole plate 121. The pressing part presses and fixes the deep hole plate 121, making the deep hole plate 121 and the fixed tray 111 stable and preventing it from shaking or falling off during high-frequency vibration.

[0053] Specifically, the top pressing part includes a top plate 112, a top pressing spring 113, and a top pressing mounting plate 114. Among them, the fixed tray 111 is provided with a top pressing mounting groove 115, and the lower part of the top plate 112 is movably arranged in the top pressing mounting groove 115. At the same time, the top pressing mounting plate 114 is provided with a bolt hole 116, and the fixed tray 111 is provided with a bolt hole at the position of the top pressing mounting groove 115, and the top pressing mounting plate 114 and the fixed tray 111 are fixedly connected by bolts. The top pressing spring 113 is arranged between the top plate 112 and the top pressing mounting plate 114, and the top plate 112 is elastically forced inward to tightly press the deep hole plate 121.

[0054] It should be noted that the deep hole plate 121 is generally rectangular, so the fixed tray 111 also adopts a rectangular form, and the top pressing part is provided with multiple and installed at the position of each side of the rectangular fixed tray 111. The top pressing force is applied to each side surface of the deep hole plate 121 to tightly press the deep hole plate 121 as a whole, and the fixed tray 111 is firmly connected to avoid shaking and falling off during high-frequency vibration.

[0055] Please refer to Figure 9 again, wherein the upper part of the top plate 112 is formed with an inverted slope 117, and the setting of the inverted slope 117 makes the installation of the deep hole plate 121 on the fixed tray 111 more convenient. Among them, the inverted slope 117 is inclined outward from bottom to top, so when the deep hole plate 121 is placed, the side surface of the deep hole plate 121 first contacts the inverted slope 117, and under the action of the inverted slope 117, the top plate 112 is extruded outward and overcomes the work of the top pressing spring 113, so that all the top plates 112 are opened, facilitating the further placement of the deep hole plate 121, until the lower surface thereof contacts the upper surface of the fixed tray 111. At this time, the side surface of the deep hole plate 121 has been moved from the inverted slope 117 of the top plate 112 to contact the vertical surface, and under the action of the top pressing spring 113, the top plate 112 tightly presses the side surface of the deep hole plate 121.

[0056] It should be noted that in order to make the whole more compact, the moving range of the top plate 112 in this embodiment is not large, and based on the need to arrange the top pressing spring 113 between the top plate 112 and the top pressing mounting plate 114, in order to ensure sufficient arrangement size of the top pressing spring 113, a spring hole with a certain depth is opened in the lower part of the top plate 112. The lower part of the top plate 112 can be provided with a sliding block, and the spring hole is arranged in the sliding block, so that one end of the top pressing spring 113 abuts against the bottom surface of the spring hole, and the other end abuts against the top pressing mounting plate 114, continuously applying an inward elastic force to the top plate 112.

[0057] In the embodiment, the top pressing mounting plate 114 is detachably connected to the fixed tray 111 by bolts, so that the top plate 112, the top pressing mounting plate 114 and the like can be conveniently mounted.

[0058] In addition, the fixed tray 111 is also provided with a heating assembly for heating the solution in the deep-well plate 121 during the movement, so as to further improve the mixing efficiency, meet the heating requirements of different samples, and the like. In the embodiment, the heating assembly is a graphene electric heating film, a ceramic heating plate or a resistance wire arranged in the fixed tray 111.

[0059] As described above, based on the fact that the deep-well plate 121 is convenient to take and place relative to the fixed tray 111, and the vibration mechanism can also synchronously complete the heating of the sample solution, the vibration mechanism provided in the embodiment is suitable for being installed on the whole sample detection pipeline for online operation. The deep-well plate 121 loaded with the solution to be mixed and heated is placed on the fixed tray 111 by a mechanical arm or the like, the top pressing part on the fixed tray 111 automatically presses and fixes the deep-well plate 121, a incoming material detection sensor or the like can be arranged to confirm the incoming material placement of the deep-well plate 121 on the fixed tray 111, and the feedback control motor 209 drives the sample carrier 100 to vibrate at high frequency and the heating assembly is heated. After the solution in the deep-well plate 121 is mixed uniformly for a preset period of time, the motor 209 can be controlled to stop at the initial angle position, the deep-well plate 121 after the internal solution is mixed is taken away by the mechanical arm and enters the next station. Based on the structure of the top pressing part, the deep-well plate 121 can be smoothly taken down when a relatively large upward force is applied to the deep-well plate 121.

[0060] In summary, by adopting the vibration mechanism provided in the embodiment, the motor 209, the eccentric wheel 201 and the like are arranged to drive the sample carrier 100 to reciprocally swing, so that the solution is vibrated at high frequency to complete rapid mixing. An optical switch 301 is arranged to detect the signal passed by the sample carrier 100, and then the motor 209 is controlled to reversely rotate according to the signal, so as to realize the regular high-frequency vibration of the deep-well plate 121, improve the uniformity of the mixing, and further ensure the stability of the sample carrier 100 and the heating and mixing of the solution by arranging the top pressing part and the heating assembly, which is suitable for the pipeline online operation.

[0061] The above describes the preferred embodiments of the present application. It should be noted that, for those skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, which should also be considered as the protection scope of the present application.

Claims

1. A vibrating mechanism, characterized by, The sample carrier (100), a rotating driving part, an eccentric wheel (201), a connecting rod (202), a first swing connecting part and a second swing connecting part are included. The sample carrier (100) is used for loading a solution. The first swing connecting part and the second swing connecting part are connected with the sample carrier (100), and the first swing connecting part and the second swing connecting part swing around the same swing axis. The eccentric wheel (201) is in transmission connection with the rotating driving part, the connecting rod (202) is connected with the eccentric wheel (201) and is eccentrically arranged relative to the rotation center of the eccentric wheel (201), the first swing connecting part is provided with a sliding groove (205), a sliding connecting piece is slidingly arranged in the sliding groove (205), the sliding connecting piece is connected with the connecting rod (202), the distribution direction of the sliding groove (205) is tangent to the swing radial direction of the first swing connecting part, when the whole is located at a swing 0-degree position, the sliding groove (205) is perpendicular to the swing symmetry plane, and when the rotating driving part drives the swing, the whole swings from the 0-degree position. The driving mode of the rotating driving part is positive and negative period rotation output.

2. A vibrating mechanism according to claim 1, wherein The first swing connecting part is a first bearing seat (203), the second swing connecting part is a second bearing seat (204), and the sliding connecting piece is a bearing (206).

3. A vibrating mechanism according to claim 2, wherein The second bearing seat (204) is provided with a connecting hole, a connecting screw (207) is arranged in the connecting hole, and the connecting screw (207) is fixed at the position of the swing axis.

4. The vibrating mechanism of claim 1, wherein The vibration mechanism further comprises a position sensor (300) for sensing the swing of the sample carrier (100).

5. A vibrating mechanism according to claim 4, wherein The position sensor (300) comprises a photoelectric switch (301) and a light blocking sheet (302), the photoelectric switch (301) is fixedly arranged, and the light blocking sheet (302) swings with the sample carrier (100).

6. The vibrating mechanism of claim 1, wherein The sample carrier (100) comprises a deep well plate (121) and a fixed tray (111). The fixed tray (111) is provided with a top plate (112), a top pressing mounting groove (115), a top pressing mounting plate (114) and a top pressing spring (113), the top plate (112) is movably connected with the top pressing mounting groove (115), the top pressing mounting plate (114) is detachably connected with the fixed tray (111), the top pressing spring (113) is arranged between the top plate (112) and the top pressing mounting plate (114), and the top plate (112) is in contact with the side surface of the deep well plate (121).

7. A vibrating mechanism according to claim 6, wherein The top plate (112) is formed with an inverted inclined surface (117) for guiding the installation of the deep well plate (121).

8. A vibrating mechanism according to claim 6, wherein The fixed tray (111) is further provided with a heating assembly, and the heating assembly is used for heating the solution.

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