Droplet fusion microfluidic method based on droplet fusion microfluidic device regulated by focused surface acoustic wave

By using a droplet fusion microfluidic device based on focused surface acoustic wave modulation, and utilizing interdigital transducers and symmetrical flow channel structures, flexible and precise fusion of different droplets and microbubbles is achieved. This solves the problems of applicability and biocompatibility of existing fusion methods and is applicable to fields such as biochemistry and medicine.

CN116273218BActive Publication Date: 2026-04-21ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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Patent Information

Application Number
CN202310070024.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-12-03
Publication Date
2026-04-21
Estimated Expiration
2041-12-03

AI Technical Summary

Technical Problem

Existing microdroplet fusion methods suffer from problems such as strict flow channel design parameters, limited applicability, limited applicability of magnetic droplets, and damage to biological samples caused by electric field fusion methods.

Method used

A droplet fusion microfluidic device based on focused surface acoustic wave modulation is adopted. It utilizes interdigital transducers to generate focused surface acoustic waves, and combines a symmetrical flow channel structure and dual-focusing arc-shaped interdigital transducers to achieve flexible fusion control of different droplets.

Benefits of technology

It achieves precise fusion between different droplets and microbubbles, has wide applicability, high flow channel structure stability, good biocompatibility, and is suitable for biochemical and medical fields.

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Abstract

The application discloses a liquid droplet fusion microfluidic method based on a liquid droplet fusion microfluidic device regulated by focused surface acoustic waves, and the device comprises an interdigital transducer, two focusing arc electrodes arranged on the interdigital transducer, and a microfluid channel system bonded on the upper part of the interdigital transducer. The focusing arc electrodes are matched with the microfluid channel system, and the microfluid channel system is provided with a first collection outlet joint, a first dispersed phase inlet joint, a continuous phase inlet joint, a second dispersed phase inlet joint and a second collection outlet joint. The focusing surface acoustic waves generated by the interdigital transducer and the liquid droplet microfluid channel structure are used to flexibly realize the fusion control of liquid droplets with different sizes in the microfluid channel. The symmetrical structure is adopted to enhance the durability and repeatability of the microfluid device. The method is not only suitable for the fusion control between microdroplets, but also suitable for the fusion control between microbubbles and between microdroplets and microbubbles. The surface acoustic waves are non-contact and have good biological compatibility, and thus meet the needs of the liquid droplet fusion technology in the fields of biochemistry and medical treatment.
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