A device for rapid detection of coronavirus

By integrating sample processing, data acquisition, and analysis, the problem of long lead times for obtaining COVID-19 test results has been solved, enabling rapid and accurate testing of multiple samples and optimizing the processing flow for large batches of samples.

CN116297384BActive Publication Date: 2026-01-27XIAMEN UNIV
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Patent Information

Application Number
CN202211547302.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-12-05
Publication Date
2026-01-27
Estimated Expiration
2042-12-05

AI Technical Summary

Technical Problem

Current COVID-19 testing methods require specialized institutions to perform nucleic acid extraction and PCR testing, resulting in long result acquisition cycles, which increases the difficulty of screening suspected patients and the risk of infection transmission.

Method used

Design a device that integrates sample processing, Raman data acquisition and analysis, and data storage, including a housing, an industrial tablet PC, a sample processing and testing mechanism, and an electronic control system, to achieve rapid sample pretreatment, data acquisition and analysis, and shorten the testing cycle.

Benefits of technology

It enables rapid processing and result acquisition of multiple samples, optimizes the processing of large batches of samples, reduces time consumption, and achieves rapid and specific identification through the characteristics of surface-enhanced Raman scattering and immunomagnetic beads, thereby reducing detection time.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application discloses a device for rapid detection of new coronavirus, and relates to the technical field of virus detection devices, solves the problem that the long period of nucleic acid detection result acquisition increases the screening difficulty of suspected patients, and integrates sample processing, Raman data collection and analysis, and data storage, wherein the working principle is based on the high sensitivity, rapid detection, and good biocompatibility of surface-enhanced Raman scattering and immunomagnetic beads, the target object can be specifically recognized and rapidly detected, the rapid processing and collection of multiple groups of samples can be simultaneously performed, multiple samples can be rapidly processed and results can be obtained in a batch, the process of data collection, data analysis, and result obtaining is integrated, the cumbersome steps of collecting data by using equipment, analyzing specified data, and obtaining results are avoided, and the period of nucleic acid detection result acquisition is effectively shortened.
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Description

Technical Field

[0001] This invention relates to the technical field of virus detection devices, and more particularly to a device for rapid detection of the novel coronavirus. Background Technology

[0002] The novel coronavirus (Coronavirus Disease 2019, COVID-19) has received increasing attention due to its high infectivity and high risk. Pneumonia caused by COVID-19 infection is mainly characterized by fever, dry cough, and fatigue, with a few patients also experiencing upper respiratory and digestive symptoms such as nasal congestion, runny nose, and diarrhea.

[0003] Current COVID-19 testing primarily uses pharyngeal swab nucleic acid testing. This method requires collecting pharyngeal swab samples from suspected patients, extracting nucleic acid from the samples, and then using fluorescent PCR technology to determine the total amount of product after each polymerase chain reaction (PCR) cycle. The amount of product after PCR amplification is then used to determine whether the nucleic acid test is negative or positive, thus enabling nucleic acid testing of suspected patients to determine whether they are infected with the COVID-19 virus. Because nucleic acid testing can only be performed by specialized nucleic acid testing institutions, after collecting the pharyngeal swab sample, it needs to be sent to a specialized nucleic acid testing institution, which generally takes 1-2 days. During the waiting period for the test results, suspected patients need to be isolated, making rapid and accurate screening of suspected patients impossible.

[0004] In conclusion, the long lead time for obtaining nucleic acid test results increases the difficulty of screening suspected patients and increases the risk of spreading pneumonia caused by COVID-19 infection. Summary of the Invention

[0005] To address the aforementioned problems, the present invention aims to provide a device for rapid detection of the novel coronavirus, which integrates sample processing, Raman data acquisition and analysis, and data storage. It is used to quickly preprocess, collect data, analyze, and obtain results from multiple samples in the same batch, and optimizes the previous process of collecting data using detection equipment first and then using the collected data for analysis, effectively shortening the cycle length for obtaining nucleic acid test results.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0007] A device for rapid detection of COVID-19 includes: a housing 1, an industrial tablet PC 2, a sample processing and testing mechanism 3, and an electronic control system 4. The electronic control system 4 is installed inside the housing 1. The sample processing and testing mechanism 3 and the electronic control system 4 are connected by wiring. The industrial tablet PC 2 is connected to the electronic control system 4. The housing 1 seals and protects the electronic control system 4 from dust. The electronic control system 4 controls the operation of the sample processing and testing mechanism 3. The sample processing and testing mechanism 3 is used for sample pretreatment and data acquisition. The industrial tablet PC 2 is used for human-computer interaction and data storage.

[0008] The aforementioned device for rapid detection of the novel coronavirus includes an electronic control system 4 comprising an internal partition 408 installed inside the outer casing 1, which divides the interior of the outer casing 1 into a first cavity and a second cavity. The sample processing and detection mechanism 3 is located in the second cavity, and the electronic control system 4 is located in the first cavity.

[0009] The aforementioned device for rapid COVID-19 testing includes an outer casing 1 comprising: a left sealing plate 101, an upper sealing plate A 103, an upper sealing plate B 104, a front sealing plate 109, a right sealing plate A 113, a right sealing plate B 114, a rear sealing plate A 116, and a rear sealing plate B 117. The upper side of the casing is composed of the upper sealing plate A 103 and the upper sealing plate B 104. The front side of the casing has a front sealing plate 109, the left side of the casing has a left sealing plate 101, and the right side of the casing is composed of a right sealing plate A 103 and a right sealing plate B 117. The outer shell is composed of a right sealing plate 113 and a right sealing plate 114. The rear side of the outer shell is composed of a rear sealing plate 116 and a rear sealing plate 117. The second cavity is formed by the left sealing plate 101, the upper sealing plate 103, the front sealing plate 109, the rear sealing plate 116 and the internal partition plate 408. The first cavity is formed by the upper sealing plate 104, the front sealing plate 109, the right sealing plate 113, the right sealing plate 114, the rear sealing plate 117 and the internal partition plate 408.

[0010] The aforementioned device for rapid detection of the novel coronavirus includes a sample processing and testing mechanism 3 comprising: a frame, a suction motor 302, a vertical lifting motor 304, a perforation motor 305, a cylinder pusher 308, a piston chamber 309, and a perforation needle 312. The suction motor 302, the perforation motor 305, the cylinder pusher 308, the piston chamber 309, and the perforation needle 312 are all mounted on the frame, and the vertical lifting motor 304 controls the up-and-down movement of the frame.

[0011] The aforementioned device for rapid detection of the novel coronavirus includes a sample processing and testing mechanism 3 that further comprises a bottom support frame 307 and a bottom slide rail 313. The bottom support frame 307 is mounted on the bottom slide rail 313, and the bottom feeding motor 301 controls the bottom support frame 307 to move back and forth on the bottom slide rail 313.

[0012] The aforementioned device for rapid detection of the novel coronavirus includes a sample processing and detection mechanism 3 that further comprises: a liquid storage component 314, multiple liquid storage components 314 mounted on a bottom support frame 307, and a perforation needle 312 positioned above the bottom support frame 307. The multiple perforation needles 312 are controlled to move up and down by a perforation motor 305 to perforate the multiple liquid storage components 314.

[0013] In the aforementioned device for rapid detection of the novel coronavirus, the piston chamber 309 is located above the bottom support frame 307. The pistons in the piston chamber 309 are all connected to the cylinder pusher 308. The cylinder pusher 308 is moved up and down by the suction motor 302 through the suction tube to adjust the pressure in the piston chamber 309 and thus realize the extraction and discharge of liquid in multiple liquid storage containers 314.

[0014] The aforementioned device for rapid detection of the novel coronavirus includes a sample processing and detection mechanism 3 that further comprises a Raman detection motor 303, a magnet 310, and a Raman probe 311. The Raman probe 311 and the magnet 310 are both located on the rear side of the frame. The Raman probe 311 is used to monitor the liquid volume in multiple liquid storage containers 314. The Raman detection motor 303 controls the left and right movement of the Raman probe 311, and the magnetic lifting motor 306 controls the up and down movement of the magnet 310.

[0015] The aforementioned device for rapid COVID-19 testing includes, in its outer casing 1, an upper cover 102, a door 110, a door handle 111, and a magnet 112. The upper cover 102 is mounted on the upper sealing plate A 103. The front sealing plate 109 has an industrial computer hole 105, an external USB hole 106, an emergency stop switch hole 107, and a main power switch hole 108. The right sealing plate B 114 has a power socket 115. The rear sealing plate B 117 has a heat dissipation fan hole 118. The door 110 is mounted on the front sealing plate 109, and a door handle 111 is mounted on the door 110. The magnet 112 is mounted on the front sealing plate 109 and is used to magnetically attract the door 110.

[0016] The aforementioned device for rapid COVID-19 detection, wherein the electronic control system 4 further includes: a Raman spectral connector 401, a Raman platform 402, a back plate 403 for electronic control unit A, a wiring hole 404, an industrial touchscreen tablet connector 405, a back plate 406 for electronic control unit B, a base plate 407 for electronic control unit C, and a back plate connector 409 for electronic control unit A. Multiple sets of slide rails are installed within the first cavity. The back plate 403 for electronic control unit A is mounted within the first cavity via two back plate connectors 409. The base plate 407 for electronic control unit C is mounted on the bottom plate of the outer casing. The back plate 403 for electronic control unit A and the base plate 407 for electronic control unit C are connected via electronic control unit B... The backplate 406 is connected, and a guide rail is installed on the backplate 403 of the electrical control component A. The Raman fixing component 401 and the backplate 403 of the electrical control component A are connected through the guide rail. The Raman platform 402 is installed on the Raman fixing component 401. The Raman fixing component 401 can be operably moved left and right through the guide rail. The industrial touch screen tablet fixing component 405 is installed in the first cavity. The industrial touch screen tablet fixing component 405 can be operably moved up and down. The industrial touch screen tablet fixing component 405 is used to install the industrial tablet computer 2. The industrial touch screen tablet fixing component 405 has multiple heat dissipation holes. The backplate 403 of the electrical control component A has multiple wire passing holes 404.

[0017] The present invention, by employing the above-mentioned technology, has the following positive effects compared with the prior art:

[0018] (1) The present invention can perform rapid processing and collection of multiple groups of samples at the same time, and can process multiple samples in the same batch and obtain results quickly, thus optimizing the processing of large batches of samples and effectively reducing the time spent on processing large batches of samples.

[0019] (2) The present invention integrates the process of data collection, data analysis and result generation into one, avoiding the cumbersome steps of first collecting data with equipment and then analyzing the specified data to obtain results, optimizing the data collection and analysis process, and effectively reducing the time spent on large batches of samples in the data collection and analysis process.

[0020] (3) This invention utilizes the rich peripheral I / O interfaces of industrial computers to add new sensor expansion device functions without modifying the design;

[0021] (4) Based on the high sensitivity and rapid detection of surface-enhanced Raman scattering, and the good biocompatibility of immunomagnetic beads, which can diffuse freely in solution and be easily separated by external magnets, this invention achieves specific identification and rapid detection of target objects, effectively reducing the time spent in the detection process. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the structure of a device for rapid detection of the novel coronavirus according to the present invention.

[0023] Figure 2 This is a right view of a device for rapid detection of the novel coronavirus according to the present invention.

[0024] Figure 3 This is a schematic diagram of the casing of a device for rapid detection of the novel coronavirus according to the present invention.

[0025] Figure 4 This is a right view of the casing of a device for rapid detection of the novel coronavirus according to the present invention.

[0026] Figure 5 This is a rear view of the casing of a device for rapid COVID-19 detection according to the present invention.

[0027] Figure 6 This is a schematic diagram of the sample processing and testing mechanism of a device for rapid detection of the novel coronavirus according to the present invention.

[0028] Figure 7 This is a bottom view of the sample processing and testing mechanism of a device for rapid detection of the novel coronavirus according to the present invention.

[0029] Figure 8 This is a left view of the sample processing and testing mechanism of a device for rapid detection of the novel coronavirus according to the present invention.

[0030] Figure 9 This is a rear view of the sample processing and testing mechanism of a device for rapid detection of the novel coronavirus according to the present invention.

[0031] Figure 10 This is a schematic diagram of the right side of the electrical control system of a device for rapid detection of the novel coronavirus according to the present invention.

[0032] Figure 11 This is a schematic diagram of the front structure of the electrical control system of a device for rapid detection of the novel coronavirus according to the present invention.

[0033] Figure 12 This is a schematic diagram of the rear structure of the electrical control system of a device for rapid detection of the novel coronavirus according to the present invention.

[0034] Figure 13 This is a schematic diagram of the upper structure of the electrical control system of a device for rapid detection of the novel coronavirus according to the present invention.

[0035] In the attached diagram: 1. Outer shell; 2. Industrial panel PC; 3. Sample processing and testing mechanism; 4. Electrical control system; 101. Left sealing plate; 102. Top cover plate; 103. Top sealing plate A; 104. Top sealing plate B; 105. Industrial computer port; 106. External USB port; 107. Emergency stop switch port; 108. Main power switch port; 109. Front sealing plate; 110. Door; 111. Door handle; 112. Magnet; 113. Right sealing plate A; 114. Right sealing plate B; 115. Power socket; 116. Rear sealing plate A; 117. Rear sealing plate B; 118. Cooling fan hole; 301. Bottom feeding motor; 302. Straw. 303. Suction motor; 304. Raman detection motor; 305. Vertical lifting motor; 306. Hole-piercing motor; 307. Magnetic lifting motor; 308. Bottom support frame; 309. Cylinder pusher; 310. Piston chamber; 311. Magnet; 312. Raman probe; 313. Hole-piercing needle; 314. Bottom slide rail; 405. Liquid storage container; 406. Raman fixing component; 407. Raman platform; 408. Backplate of electrical control component A; 409. Wiring hole; 400. Fixing component for industrial touch screen tablet; 400. Backplate of electrical control component B; 401. Base plate of electrical control component C; 402. Internal partition plate; 403. Fixing component for backplate of electrical control component A. Detailed Implementation

[0036] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, but this is not intended to limit the scope of the invention.

[0037] Please refer to Figures 1 to 13 As shown, a device for rapid detection of COVID-19 is illustrated, comprising: a housing 1, an industrial tablet computer 2, a sample processing and testing mechanism 3, and an electronic control system 4. The electronic control system 4 is installed inside the housing 1. The sample processing and testing mechanism 3 and the electronic control system 4 are connected by wiring. The industrial tablet computer 2 is connected to the electronic control system 4. The housing 1 seals and protects the electronic control system 4 from dust. The electronic control system 4 controls the operation of the sample processing and testing mechanism 3. The sample processing and testing mechanism 3 is used for sample pretreatment and data acquisition. The industrial tablet computer 2 is used for human-computer interaction and data storage.

[0038] Furthermore, in a preferred embodiment, the electronic control system 4 includes: an internal partition plate 408, which is installed inside the housing 1 and divides the interior of the housing 1 into a first cavity and a second cavity. The sample processing and detection mechanism 3 is located in the second cavity, and the electronic control system 4 is located in the first cavity.

[0039] Furthermore, in a preferred embodiment, the outer casing 1 includes: a left sealing plate 101, an upper sealing plate A 103, an upper sealing plate B 104, a front sealing plate 109, a right sealing plate A 113, a right sealing plate B 114, a rear sealing plate A 116, and a rear sealing plate B 117. The upper side of the outer casing is composed of the upper sealing plate A 103 and the upper sealing plate B 104. The front side of the outer casing is provided with a front sealing plate 109. The left side of the outer casing is provided with a left sealing plate 101, and the right side of the outer casing is provided with a right sealing plate A 109. The outer shell is composed of a right sealing plate B and a right sealing plate B 114. The rear side of the outer shell is composed of a rear sealing plate A 116 and a rear sealing plate B 117. The second cavity is formed by the left sealing plate 101, the upper sealing plate A 103, the front sealing plate 109, the rear sealing plate A 116 and the internal partition plate 408. The first cavity is formed by the upper sealing plate B 104, the front sealing plate 109, the right sealing plate A 113, the right sealing plate B 114, the rear sealing plate B 117 and the internal partition plate 408.

[0040] Furthermore, in a preferred embodiment, the sample processing and testing mechanism 3 includes: a frame, a suction motor 302, a vertical lifting motor 304, a piercing motor 305, a cylinder pusher 308, a piston chamber 309, and a piercing needle 312. The suction motor 302, the piercing motor 305, the cylinder pusher 308, the piston chamber 309, and the piercing needle 312 are all mounted on the frame, and the vertical lifting motor 304 controls the up and down movement of the frame.

[0041] Furthermore, in a preferred embodiment, the sample processing and testing mechanism 3 further includes: a bottom support frame 307 and a bottom slide rail 313. The bottom support frame 307 is mounted on the bottom slide rail 313, and the bottom feeding motor 301 controls the bottom support frame 307 to move back and forth on the bottom slide rail 313.

[0042] Furthermore, in a preferred embodiment, the sample processing and testing mechanism 3 further includes: a liquid storage component 314, a plurality of liquid storage components 314 are installed on the bottom support frame 307, and a puncture needle 312 is disposed above the bottom support frame 307. The plurality of puncture needles 312 are controlled to move up and down by the puncture motor 305 to puncture the plurality of liquid storage components 314.

[0043] Furthermore, in a preferred embodiment, the piston chamber 309 is located above the bottom support frame 307, and the pistons in the piston chamber 309 are all connected to the cylinder pusher 308. The cylinder pusher 308 is controlled to move up and down by the suction motor 302 through the suction tube to adjust the pressure in the piston chamber 309, thereby realizing the extraction and discharge of liquid in multiple liquid storage containers 314.

[0044] Furthermore, in a preferred embodiment, the sample processing and detection mechanism 3 further includes: a Raman detection motor 303, a magnet 310, and a Raman probe 311. The Raman probe 311 and the magnet 310 are both located on the rear side of the frame. The Raman probe 311 is used to monitor the liquid volume in multiple liquid storage containers 314. The Raman detection motor 303 controls the left and right movement of the Raman probe 311, and the magnetic lifting motor 306 controls the up and down movement of the magnet 310.

[0045] Furthermore, in a preferred embodiment, the outer casing 1 further includes: an upper cover plate 102, a switch door 110, a door handle 111, and a magnet 112. The upper cover plate 102 is mounted on the upper sealing plate A 103. The front sealing plate 109 is provided with an industrial computer hole 105, an external USB hole 106, an emergency stop switch hole 107, and a main power switch hole 108. The right sealing plate B 114 is provided with a power socket 115. The rear sealing plate B 117 is provided with a heat dissipation fan hole 118. The switch door 110 is mounted on the front sealing plate 109. The door handle 111 is mounted on the switch door 110. The magnet 112 is mounted on the front sealing plate 109 and is used to magnetically attract the switch door 110.

[0046] Furthermore, in a preferred embodiment, the electronic control system 4 further includes: a Raman fixing member 401, a Raman platform 402, a back plate 403 for electronic control component A, a wiring hole 404, an industrial touchscreen tablet fixing member 405, a back plate 406 for electronic control component B, a base plate 407 for electronic control component C, and a fixing member 409 for the back plate 409 of electronic control component A. Multiple sets of slide rails are installed in the first cavity. The back plate 403 for electronic control component A is installed in the first cavity via two fixing members 409. The base plate 407 for electronic control component C is installed on the bottom plate of the outer casing. The back plate 403 for electronic control component A and the base plate 407 for electronic control component C are connected via the back plate 409 for electronic control component B. 6. A guide rail is installed on the back plate 403 of the electrical control component A. The Raman fixing component 401 and the back plate 403 of the electrical control component A are connected through the guide rail. The Raman platform 402 is installed on the Raman fixing component 401. The Raman fixing component 401 can be operably moved left and right through the guide rail. The industrial touch screen tablet fixing component 405 is installed in the first cavity. The industrial touch screen tablet fixing component 405 can be operably moved up and down. The industrial touch screen tablet fixing component 405 is used to install the industrial tablet computer 2. The industrial touch screen tablet fixing component 405 has multiple heat dissipation holes. The back plate 403 of the electrical control component A has multiple wire passing holes 404.

[0047] The above are merely preferred embodiments of the present invention and are not intended to limit the implementation methods and protection scope of the present invention.

[0048] In addition to the above, the present invention also has the following embodiments:

[0049] In a further embodiment of the present invention, the present invention is divided into four parts, as follows: Figure 1 and Figure 2As shown, the components are: outer shell 1, industrial panel PC 2, sample processing and testing mechanism 3, and electrical control system 4. The outer shell 1 serves as the base of the entire device, providing a sealed and dustproof function. The industrial panel PC 2 provides user software interface control, interaction with the main controller, and storage of test data. The sample processing and testing mechanism 3 consists of 6 stepper motors and corresponding mechanical structures, undertaking the functions of sample pretreatment and Raman data acquisition. The electrical control system 4 includes the main control device for controlling the 6 stepper motors, fixtures for placing the Raman development platform for data acquisition, power supply for various sensors, and wiring for device operation.

[0050] In a further embodiment of the present invention, the outer shell 1 portion is as follows: Figures 3 to 5 As shown, the top cover 102, the switch door 110, and the rear sealing plate A 116 are all made of dark semi-transparent acrylic sheets, allowing the internal operation to be viewed from multiple directions; the switch door 110 is installed on the front sealing plate 109 using upper and lower pins; the switch door 110 is kept closed by magnetic attraction using magnet 112; the right sealing plate A 113 has slots and heat dissipation fan holes 118 to ensure heat dissipation of the main control unit.

[0051] In a further embodiment of the present invention, the industrial tablet PC 2 is mainly responsible for carrying user control software, providing functions such as interface display, user touch screen operation, storage and analysis of measurement data, and interaction with the lower-level main control unit; it has an onboard Intel CPU with numerous I / O interfaces. The industrial tablet PC 2 in this device uses an Ethernet interface for communication with the PLC; it uses a serial-to-USB interface for connection with the temperature sensor; and it uses an RS232 interface for connection with the Raman detection device.

[0052] In a further embodiment of the present invention, the industrial computer also provides a wireless connection function, which can interact with other devices wirelessly in a closed laboratory or in an environment where wired internet access is inconvenient. The data obtained from each test is stored on the local disk of the industrial computer. It can be connected to other devices, such as a mouse, keyboard, external barcode scanner, etc., through the two external USB ports 106 on the outer casing 1 via an extension cable.

[0053] In a further embodiment of the present invention, the sample processing and detection mechanism 3 consists of six motors and mechanical structures controlled by them, such as... Figures 6 to 9As shown, the bottom feeding motor 301 controls the bottom support frame 307 to move back and forth on the bottom slide rail 313, thereby controlling the entire bottom support frame 307 to reach a specified horizontal position; the suction motor 302 controls the cylinder pusher 308 to move up and down in the piston chamber 309, which has good airtightness, thereby controlling the suction of a specified amount of liquid; the Raman detection motor 303 controls the Raman probe 311 to move left and right on the lead screw so that the Raman probe 311 can reach various points on the bottom support frame 307. The observation platform of the liquid storage component 314 includes a vertical lifting motor 304 that controls the up-and-down movement of a suction motor 302, a piercing motor 305, a cylinder pusher 308, a piston chamber 309, and a piercing needle 312, thereby controlling the movement to a designated position in the vertical direction. The piercing motor 305 controls the piercing needle 312 to pierce the liquid storage component 314 at the beginning of the detection process. An aluminum foil film will be placed over the liquid storage component 314 for transportation and dust and contamination prevention. The magnetic motor 306 controls the raising and lowering of the magnet 310.

[0054] In a further embodiment of the present invention, the electronic control system 4 comprises the following components: Raman fixing member 401, Raman platform 402, back plate 403 of electronic control component A, three through holes 404, industrial touch screen flat plate fixing member 405, back plate 406 of electronic control component B, base plate 407 of electronic control component C, internal partition plate 408, and two fixing members 409 of back plate 409 of electronic control component A. The entire device is divided into two spaces by the internal partition plate 408, and the Raman platform 402 is fixed using additional back plates 403, 406, and 407 of electronic control component A and C. Guide rails are installed on the back plate 403 of electronic control component A, and the Raman platform 402 is fixed on the guide rails. Cable trays are installed for wiring, which can effectively fix the internal Raman platform 402 and prevent the Raman platform 402 from shaking during the movement of the device.

[0055] In a further embodiment of the present invention, the Raman platform 402 is connected to the Raman detection motor 303, sensor, and Raman probe 311 of the sample processing and detection mechanism 3 through a wire hole 404.

[0056] In a further embodiment of the present invention, the industrial touch screen tablet fixing component 405 is fixed to the slide rail of the outer shell 1 by four screws, and three heat dissipation holes are provided on the industrial touch screen tablet fixing component 405 and the back of the touch screen computer.

[0057] In a further embodiment of the present invention, the Raman fixing member 401 is shaped as follows: Figure 13 As shown, it is L-shaped and is directly fixed to the slide rail of the outer shell 1 through the screw hole at the top. It can move the Raman fastener 401 left and right to match the internal space layout.

[0058] In a further embodiment of the present invention, the back plate 403 of the control component A is fixed to the internal slide rail of the outer shell 1 by two back plate fixing members 409 of the control component A; the bottom plate 407 of the control component C is directly fixed to the bottom plate of the outer shell 1; the back plate 406 of the control component B is connected to the back plate fixing members 409 of the control component A and the bottom plate 407 of the control component C by welding.

[0059] In a further embodiment of the present invention, the working principle is based on the high sensitivity and rapid detection of surface-enhanced Raman scattering, and the good biocompatibility of immunomagnetic beads, which can freely diffuse in solution and be easily separated by an external magnet, thus achieving specific identification and rapid detection of target analytes. The present invention can currently perform rapid processing and collection of multiple sets of samples simultaneously, and can process multiple samples in the same batch to obtain results quickly. The present invention integrates the processes of data acquisition, data analysis, and result generation into one, avoiding the cumbersome steps of first collecting data with equipment and then analyzing specific data to obtain results. The present invention utilizes the rich peripheral I / O interfaces of industrial computers, allowing for the addition of new sensors to expand device functionality without modifying the design.

[0060] The above are merely preferred embodiments of the present invention and are not intended to limit the implementation methods and protection scope of the present invention. Those skilled in the art should recognize that any equivalent substitutions and obvious changes made based on the description and illustrations of the present invention should be included within the protection scope of the present invention.

Claims

1. A device for rapid detection of the novel coronavirus, characterized in that, include: The enclosure (1), industrial tablet PC (2), sample processing and testing mechanism (3) and electronic control system (4) are installed inside the enclosure (1). The sample processing and testing mechanism (3) and electronic control system (4) are connected by a line. The industrial tablet PC (2) is connected to the electronic control system (4). The enclosure (1) seals the electronic control system (4) to prevent dust. The electronic control system (4) controls the operation of the sample processing and testing mechanism (3). The sample processing and testing mechanism (3) is used for sample pretreatment and data acquisition. The industrial tablet PC (2) is used for human-computer interaction and data storage. The sample processing and testing mechanism (3) includes: a frame, a suction motor (302), a vertical lifting motor (304), a puncture motor (305), a cylinder pusher (308), a piston chamber (309), and a puncture needle (312). The suction motor (302), the puncture motor (305), the cylinder pusher (308), the piston chamber (309), and the puncture needle (312) are all mounted on the frame, and the vertical lifting motor (304) controls the up and down movement of the frame. The sample processing and testing mechanism (3) further includes: a bottom support frame (307) and a bottom slide rail (313). The bottom support frame (307) is installed on the bottom slide rail (313), and the bottom feeding motor (301) controls the bottom support frame (307) to move back and forth on the bottom slide rail (313). The sample processing and testing mechanism (3) further includes: a liquid storage component (314), a plurality of liquid storage components (314) are installed on the bottom support frame (307), and a piercing needle (312) is located above the bottom support frame (307). The piercing motor (305) controls the multiple piercing needles (312) to move up and down to pierce the multiple liquid storage components (314). The sample processing and testing mechanism (3) further includes: a Raman detection motor (303), a magnet (310) and a Raman probe (311). The Raman probe (311) and the magnet (310) are both located on the rear side of the frame. The Raman probe (311) is used to monitor the liquid volume in multiple liquid storage containers (314). The Raman detection motor (303) controls the left and right movement of the Raman probe (311), and the magnetic lifting motor (306) controls the up and down movement of the magnet (310). The electronic control system (4) further includes: a Raman fixing component (401), a Raman platform (402), an electronic control component A backplate (403), a wiring hole (404), an industrial touch screen tablet fixing component (405), an electronic control component B backplate (406), an electronic control component C base plate (407), and an electronic control component A backplate fixing component (409). Multiple sets of slide rails are installed in the first cavity. The electronic control component A backplate (403) is installed in the first cavity via two electronic control component A backplate fixing components (409). The electronic control component C base plate (407) is installed on the outer casing base plate. The electronic control component A backplate (403) and the electronic control component C base plate (407) are connected via... The backplate (406) of the electrical control component B is connected, and the backplate (403) of the electrical control component A is equipped with a guide rail. The Raman fixing component (401) and the backplate (403) of the electrical control component A are connected by the guide rail. The Raman platform (402) is installed on the Raman fixing component (401). The Raman fixing component (401) moves left and right by the guide rail. The industrial touch screen tablet fixing component (405) is installed in the first cavity. The industrial touch screen tablet fixing component (405) is used to install the industrial tablet computer (2). The industrial touch screen tablet fixing component (405) has multiple heat dissipation holes. The backplate (403) of the electrical control component A has multiple wire passing holes (404).

2. The device for rapid detection of COVID-19 according to claim 1, characterized in that, The electronic control system (4) includes: an internal partition plate (408), which is installed inside the outer shell (1) and divides the interior of the outer shell (1) into a first cavity and a second cavity. The sample processing and detection mechanism (3) is located in the second cavity, and the electronic control system (4) is located in the first cavity.

3. The device for rapid detection of the novel coronavirus according to claim 2, characterized in that, The outer casing (1) includes: a left sealing plate (101), an upper sealing plate A (103), an upper sealing plate B (104), a front sealing plate (109), a right sealing plate A (113), a right sealing plate B (114), a rear sealing plate A (116), and a rear sealing plate B (117). The upper side of the outer casing is composed of the upper sealing plate A (103) and the upper sealing plate B (104). The front side of the outer casing is provided with a front sealing plate (109), the left side of the outer casing is provided with a left sealing plate (101), and the right side of the outer casing is composed of the right sealing plate A (113) and the right sealing plate B (117). The shell is composed of a plate (114), and the rear side of the shell is composed of a rear sealing plate A (116) and a rear sealing plate B (117). The second cavity is formed by the left sealing plate (101), the upper sealing plate A (103), the front sealing plate (109), the rear sealing plate A (116) and the internal partition plate (408). The first cavity is formed by the upper sealing plate B (104), the front sealing plate (109), the right sealing plate A (113), the right sealing plate B (114), the rear sealing plate B (117) and the internal partition plate (408).

4. The device for rapid detection of the novel coronavirus according to claim 1, characterized in that, The piston chamber (309) is located above the bottom support frame (307). The pistons in the piston chamber (309) are all connected to the cylinder pusher (308). The cylinder pusher (308) is controlled to move up and down by the suction motor (302) to adjust the pressure in the piston chamber (309) and thus realize the pumping of liquid in multiple liquid storage devices (314).

5. The device for rapid detection of the novel coronavirus according to claim 3, characterized in that, The outer casing (1) also includes: an upper cover plate (102), a switch door (110), a door handle (111), and a magnet (112). The upper cover plate (102) is installed on the upper sealing plate A (103). The front sealing plate (109) is provided with an industrial computer hole (105), an external USB hole (106), an emergency stop switch hole (107), and a main power switch hole (108). The right sealing plate B (114) is provided with a power socket hole (115). The rear sealing plate B (117) is provided with a heat dissipation fan hole (118). The switch door (110) is installed on the front sealing plate (109). The switch door (110) is provided with a door handle (111). The front sealing plate (109) is provided with a magnet (112). The magnet (112) is used to magnetically attract the switch door (110).

Citation Information

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