A cream and its preparation method and application

Abstract

The invention belongs to the field of natural plant extract skin care products, discloses a cream and a preparation method and application thereof, wherein the effective ingredients of the cream are composed of the following raw materials in parts by weight: 15-20 parts of Herba Citri Reticulatae Extract, 10-20 parts of Kochia scopariae Extract, 5-10 parts of Wolfberry Chamaejasme Extract, 3-6 parts of Solidago striatae Extract, 3-6 parts of modified chitosan, 3-5 parts of sodium hyaluronate, 2-4 parts of borneol, 2-3 parts of allantoin, 1-2 parts of menthol, 0.5-1 parts of tocopherol acetate and 0.5-1 parts of methylparaben; the Herba Citri Reticulatae Extract, the Kochia scopariae Extract, the Wolfberry Chamaejasme Extract and the Solidago striatae Extract are used in combination, and it is found that the cream has a good effect on preventing and improving the symptoms of premenstrual acne in women, and the main effective ingredients of the cream are natural plant extracts, the cream has low irritation, does not contain antibiotics and irritating chemical agents, and has good industrial prospects.

Description

Technical Field

[0001] The invention belongs to the field of natural plant extraction, and specifically discloses a cream with therapeutic effect on menstrual acne, a preparation method and application thereof. Background Art

[0002] Acne is a chronic inflammatory skin disease of the pilosebaceous gland unit, which mainly occurs in adolescents and has a great impact on their psychology and social life, but it often alleviates or heals naturally after puberty. The clinical manifestations are characterized by polymorphic skin lesions such as acne, papules, pustules, nodules, etc. that are prone to occur on the face. The occurrence of acne is closely related to factors such as excessive sebum secretion, blockage of the pilosebaceous gland ducts, bacterial infection and inflammatory response. After entering puberty, the level of androgens in the human body, especially testosterone, rises rapidly, promoting the development of sebaceous glands and producing a large amount of sebum. At the same time, abnormal keratinization of the pilosebaceous gland duct causes blockage of the duct, obstruction of sebum excretion, and formation of keratin plugs, namely micro-acnes. Various microorganisms, especially Propionibacterium acnes, multiply in the hair follicles. The lipase produced by Propionibacterium acnes decomposes sebum to produce free fatty acids, while chemotacticizing inflammatory cells and mediators, ultimately inducing and aggravating inflammatory responses. Acne is mainly divided into the following categories:

[0003] 1. Common acne, more common in young people, is prone to occur in areas with abundant sebaceous glands such as the cheeks, forehead, chest and back. At the beginning, papules can be seen at the opening of the hair follicles, and light yellow sebum plugs can be squeezed out, which are called comedones. If the opening of the hair follicles is open, the sebum plugs will turn black due to oxidation and dust, which are called blackheads. 2. Acne fulminans: refers to the sudden worsening of the patient's condition, with the appearance of multiple, inflammatory, follicular papules, pustules, ulcers, and blood scabs. The rash can merge into large patches, and systemic symptoms such as fever, joint pain, and anemia may occur; 3. Premenstrual acne: The level of male hormones increases some time before menstruation, or the ratio of male hormones to female hormones increases relatively, the sebaceous glands enlarge, and sebum secretion increases, leading to sebum congestion and the growth of Propionibacterium acnes, resulting in premenstrual acne, which gradually improves after the menstrual period; 4. Cosmetic acne: Cosmetic acne is caused by the use of inferior oily or powdery skin care products that cause pores to become clogged and cause inflammation; 5. Drug-induced acne: Drug-induced acne is related to the use of certain medications, the most common of which are glucocorticoids, as well as androgens, targeted drugs, etc. This type of acne is characterized by inflammatory skin lesions.

[0004] Currently, creams that have therapeutic effects on acne often contain a large amount of Western medicine ingredients, such as retinoic acid, benzoyl peroxide and other drugs. While treating acne, side effects such as allergies or skin barrier damage may also occur. In addition, such creams often have a good effect on common acne, but have a poor effect on premenstrual acne, which is more affected by hormones. Therefore, it is necessary to design a cream skin care product for premenstrual acne, especially a Chinese medicine cream product with fewer side effects. Summary of the invention

[0005] The invention aims to provide a cream for preventing and improving female premenstrual acne symptoms.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] A cream, composed of active ingredients and auxiliary materials, wherein the active ingredients are composed of the following raw materials in parts by weight:

[0008] 15-20 parts of Herba Citri Reticulatae Extract, 10-20 parts of Kochia scoparia Extract, 5-10 parts of Stellera Chamaejasme Extract, 3-6 parts of Solidago scabra Extract, 3-6 parts of Modified Chitosan, 3-5 parts of Sodium Hyaluronate, 2-4 parts of Borneolum Syntheticum, 2-3 parts of Allantoin, 1-2 parts of Menthol, 0.5-1 parts of Tocopherol Acetate, and 0.5-1 parts of Methylparaben;

[0009] The auxiliary materials are composed of the following raw materials in parts by weight:

[0010] 20-40 parts of liquid paraffin, 15-20 parts of glycerol, 14-18 parts of stearic acid, 5-10 parts of glyceryl monostearate, 4-6 parts of lanolin, 1-2 parts of flavor, and 50-60 parts of deionized water.

[0011] In the above scheme, the extract of Herba Citri Reticulatae is effective in enhancing the contraction of capillaries and clearing away heat; the extract of Fructus Kochiae has the effects of clearing away heat and dampness, dispelling wind and relieving itching; the extract of Herba Lycopodii has the effects of dispersing nodules and killing insects; the extract of Herba Solidagoe and tocopherol acetate have the effects of anti-inflammatory, antioxidant and anti-aging; sodium hyaluronate can increase the moisturizing function of the skin; and borneol is often used for sores, swelling and pain, and the ulcer does not heal, and has a strong astringent property; allantoin has the physiological functions of promoting cell growth, accelerating wound healing, softening keratin and the like; and menthol has a cooling and relieving itching effect; the above ingredients work together to keep the skin moisturized, anti-wrinkle, and relieve allergies and acne symptoms.

[0012] Furthermore, in the above-mentioned cream, the Herba Citri Reticulatae Extract is prepared by the following steps:

[0013] Fresh leaves of Potentilla fruticosa are squeezed for juice, and the juice is filtered through a 45 μm filter membrane, and the filtrate is concentrated by rotary evaporation to obtain a brown concentrate, which is then dried to obtain a brown powder, which is the Potentilla fruticosa extract. Preferably, Potentilla fruticosa microphylla is selected.

[0014] Furthermore, in the above-mentioned cream, the modified chitosan is prepared by the following steps:

[0015] According to the weight percentage, 10 parts of chitosan raw materials are added to 10-20 parts of 15% acetic acid solution, ice-water bath, and the reaction temperature is controlled at 0-5°C; 2-4 parts of lecithin and 1-2 parts of hydroxypropyl distarch phosphate are added under stirring; after the addition is completed, the ice-water bath is removed, and the reaction is continuously stirred at 30-40°C for 4-8 hours; the modified chitosan is obtained by standing, precipitation, suction filtration, drying, and recrystallization. Chitosan is the product of N-deacetylation of chitin. Chitin (chitin), chitosan, and cellulose have similar chemical structures. Cellulose is hydroxyl at the C2 position, and chitin and chitosan are replaced by an acetylamino group and an amino group at the C2 position, respectively. Chitin and chitosan have many unique properties such as biodegradability, cell affinity, and biological effects. In particular, chitosan containing free amino groups is the only alkaline polysaccharide among natural polysaccharides. After modification, the groups connected to lecithin and hydroxypropyl distarch phosphate have better amphiphilicity and can better promote the entry of active ingredients into the skin.

[0016] Furthermore, the above-mentioned cream comprises the following steps:

[0017] Step S1, adding liquid paraffin, stearic acid, glyceryl monostearate, and lanolin into an oil phase container, heating until completely dissolved, and stirring evenly;

[0018] Step S2, adding a portion of deionized water into the water phase container A, adding the extract of Herba Citri Reticulatae, the extract of Fructus Kochiae, the extract of Stellera Chamaejasme, and the extract of Solidago asiatica, heating, stirring until completely dissolved, and then adding glycerin and stirring evenly;

[0019] Step S3, adding the remaining deionized water into another aqueous phase container B, adding chitosan, sodium hyaluronate, borneol, allantoin, menthol, and mechanically stirring until completely dissolved;

[0020] Step S4, adding the liquid in the oil phase container to the water phase container A under stirring, and then sequentially adding the liquid in the water phase container B and tocopherol acetate, and continuing stirring;

[0021] Step S5, homogenizing the mixture obtained in step S4;

[0022] Step S6, adding methylparaben and essence to the homogenized mixture, continuing stirring, and discharging to obtain the cream.

[0023] Preferably, in step S1, the heating temperature is 80-90°C.

[0024] Preferably, in step S2, the heating temperature is 60-70°C.

[0025] Preferably, 3 / 5 of deionized water is added in step S2, and the remaining 2 / 5 of deionized water is added in step S3.

[0026] Preferably, in step S3, the mixture is kept warm at 70-80° C. after being completely dissolved.

[0027] Preferably, in step S5, the temperature is lowered to 45-55° C. and homogenized for 5-10 minutes.

[0028] The present invention has the following beneficial effects:

[0029] The extract of Potentilla fruticosa has the effects of enhancing capillary contraction and clearing away heat; the extract of Kochia scoparia has the effects of clearing away heat and dampness, dispelling wind and relieving itching; the extract of Wolfberry chamaejasme has the effects of dispersing nodules and killing insects; the extract of Solidago asiatica and tocopherol acetate have the effects of anti-inflammatory, antioxidant and anti-aging; the present invention uses the above-mentioned effective substances in combination, and it is found that they have a good effect of improving the symptoms of premenstrual acne. Furthermore, the present invention also finds that the cream prepared in the present invention and retinoic acid are prepared into a composition at the same time, which can treat common acne and premenstrual acne at the same time, and is very suitable for use by young and middle-aged female patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Attached Figure 1 Comparison of the improvement of premenstrual acne symptoms in Example 2 and Comparative Examples 1-6;

[0031] Attached Figure 2 The improvement rates of premenstrual acne symptoms in Example 2 and Comparative Examples 1-6 are compared. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] The reagents or instruments used in the examples of the present invention without indicating the manufacturer are all conventional reagent products that can be obtained through commercial purchase.

[0034] Kochia scoparia seed extract was purchased from Hubei Keword Chemical Co., Ltd. with item number kds321215 and a purity of 99%.

[0035] Wolf chamaejasme extract was purchased from Shaanxi Xintianyu Biotechnology Co., Ltd., 1 kg / aluminum foil bag, extracted from the root, with a purity of 99%.

[0036] Solidago asiatica extract was purchased from Shandong Yatu Biotechnology Co., Ltd., CAS No. 112509-54-3, purity 99%.

[0037] Example 1

[0038] A cream, composed of active ingredients and auxiliary materials, wherein the active ingredients are composed of the following raw materials:

[0039] 15g of Herba Citri Reticulatae Extract, 10g of Kochia scoparia Extract, 5g of Wolfberry Chamaejasme Extract, 3g of Solidago asiatica Extract, 3g of Modified Chitosan, 3g of Sodium Hyaluronate, 2g of Borneolum Syntheticum, 2g of Allantoin, 1g of Menthol, 0.5g of Tocopherol Acetate, and 0.5g of Methylparaben;

[0040] The auxiliary materials are composed of the following raw materials:

[0041] 20g liquid paraffin, 15g glycerol, 14g stearic acid, 5g glyceryl monostearate, 4g lanolin, 1g essence, and 50g deionized water.

[0042] The Herba Citri Reticulatae Extract is prepared by the following steps:

[0043] Fresh leaves of Potentilla fruticosa are squeezed for juice, and the juice is filtered through a 45 μm filter membrane. The filtrate is concentrated by rotary evaporation to obtain a brown concentrated solution, which is then dried to obtain a brown powder, which is the Potentilla fruticosa extract.

[0044] The modified chitosan is prepared by the following steps:

[0045] Add 10g chitosan raw material to 15g 15% acetic acid solution, place in an ice-water bath, and control the reaction temperature at 0-5°C; add 3g lecithin and 1.5g hydroxypropyl distarch phosphate under stirring; remove the ice-water bath after the addition is complete, and continue stirring the reaction at 30-40°C for 4-8h; and obtain modified chitosan by standing, precipitation, suction filtration, drying, and recrystallization.

[0046] The preparation method of the above cream comprises the following steps:

[0047] Step S1, adding liquid paraffin, stearic acid, glyceryl monostearate, and lanolin into an oil phase container, heating until completely dissolved, and stirring evenly;

[0048] Step S2, adding a portion of deionized water into the water phase container A, adding the extract of Herba Citri Reticulatae, the extract of Fructus Kochiae, the extract of Stellera Chamaejasme, and the extract of Solidago asiatica, heating, stirring until completely dissolved, and then adding glycerin and stirring evenly;

[0049] Step S3, adding the remaining deionized water into another aqueous phase container B, adding chitosan, sodium hyaluronate, borneol, allantoin, menthol, and mechanically stirring until completely dissolved;

[0050] Step S4, adding the liquid in the oil phase container to the water phase container A under stirring, and then sequentially adding the liquid in the water phase container B and tocopherol acetate, and continuing stirring;

[0051] Step S5, homogenizing the mixture obtained in step S4;

[0052] Step S6, adding methylparaben and essence to the homogenized mixture, continuing stirring, discharging, and obtaining the cream;

[0053] In step S1, the heating temperature is 80-90°C;

[0054] In step S2, the heating temperature is 60-70°C;

[0055] In step S2, 3 / 5 of deionized water is added, and in step S3, the remaining 2 / 5 of deionized water is added;

[0056] In the step S3, the mixture is kept warm at 70-80° C. after being completely dissolved;

[0057] In step S5, the temperature is lowered to 45-55° C. and homogenized for 5-10 minutes.

[0058] Example 2

[0059] A cream, composed of active ingredients and auxiliary materials, wherein the active ingredients are composed of the following raw materials:

[0060] 18g of Herba Citri Reticulatae Extract, 15g of Kochia scoparia Extract, 7g of Wolfberry Extract, 4.5g of Solidago asiatica Extract, 4.5g of Modified Chitosan, 4.5g of Sodium Hyaluronate, 3g of Borneolum Syntheticum, 2.5g of Allantoin, 1.5g of Menthol, 0.8g of Tocopherol Acetate, and 0.8g of Methylparaben;

[0061] The auxiliary materials are composed of the following raw materials by weight:

[0062] 30g liquid paraffin, 18g glycerol, 16g stearic acid, 8g glyceryl monostearate, 5g lanolin, 1.5g essence, and 55g deionized water.

[0063] The Herba Citri Reticulatae Extract is prepared by the following steps:

[0064] Fresh leaves of Potentilla fruticosa are squeezed for juice, and the juice is filtered through a 45 μm filter membrane. The filtrate is concentrated by rotary evaporation to obtain a brown concentrated solution, which is then dried to obtain a brown powder, which is the Potentilla fruticosa extract.

[0065] The modified chitosan is prepared by the following steps:

[0066] Add 10g chitosan raw material to 15g 15% acetic acid solution, place in an ice-water bath, and control the reaction temperature at 0-5°C; add 3g lecithin and 1.5g hydroxypropyl distarch phosphate under stirring; remove the ice-water bath after the addition is complete, and continue stirring the reaction at 30-40°C for 4-8h; and obtain modified chitosan by standing, precipitation, suction filtration, drying, and recrystallization.

[0067] The preparation method of the above cream comprises the following steps:

[0068] Step S1, adding liquid paraffin, stearic acid, glyceryl monostearate, and lanolin into an oil phase container, heating until completely dissolved, and stirring evenly;

[0069] Step S2, adding a portion of deionized water into the water phase container A, adding the extract of Herba Citri Reticulatae, the extract of Fructus Kochiae, the extract of Stellera Chamaejasme, and the extract of Solidago asiatica, heating, stirring until completely dissolved, and then adding glycerin and stirring evenly;

[0070] Step S3, adding the remaining deionized water into another aqueous phase container B, adding chitosan, sodium hyaluronate, borneol, allantoin, menthol, and mechanically stirring until completely dissolved;

[0071] Step S4, adding the liquid in the oil phase container to the water phase container A under stirring, and then sequentially adding the liquid in the water phase container B and tocopherol acetate, and continuing stirring;

[0072] Step S5, homogenizing the mixture obtained in step S4;

[0073] Step S6, adding methylparaben and essence to the homogenized mixture, continuing stirring, discharging, and obtaining the cream;

[0074] In step S1, the heating temperature is 80-90°C;

[0075] In step S2, the heating temperature is 60-70°C;

[0076] In step S2, 3 / 5 of deionized water is added, and in step S3, the remaining 2 / 5 of deionized water is added;

[0077] In the step S3, the mixture is kept warm at 70-80° C. after being completely dissolved;

[0078] In step S5, the temperature is lowered to 45-55° C. and homogenized for 5-10 minutes.

[0079] Example 3

[0080] A cream, composed of active ingredients and auxiliary materials, wherein the active ingredients are composed of the following raw materials:

[0081] 20g of Herba Citri Reticulatae Extract, 20g of Kochia scoparia Extract, 10g of Wolfberry Extract, 6g of Solidago asiatica Extract, 6g of Modified Chitosan, 5g of Sodium Hyaluronate, 4g of Borneolum Syntheticum, 3g of Allantoin, 2g of Menthol, 1g of Tocopherol Acetate, and 1g of Methylparaben;

[0082] The auxiliary materials are composed of the following raw materials by weight:

[0083] 40g liquid paraffin, 20g glycerin, 18g stearic acid, 10g glyceryl monostearate, 6g lanolin, 2g essence, and 60g deionized water.

[0084] The Herba Citri Reticulatae Extract is prepared by the following steps:

[0085] Fresh leaves of Potentilla fruticosa are squeezed for juice, and the juice is filtered through a 45 μm filter membrane. The filtrate is concentrated by rotary evaporation to obtain a brown concentrated solution, which is then dried to obtain a brown powder, which is the Potentilla fruticosa extract.

[0086] The modified chitosan is prepared by the following steps:

[0087] Add 10g chitosan raw material to 15g 15% acetic acid solution, place in an ice-water bath, and control the reaction temperature at 0-5°C; add 3g lecithin and 1.5g hydroxypropyl distarch phosphate under stirring; remove the ice-water bath after the addition is complete, and continue stirring the reaction at 30-40°C for 4-8h; and obtain modified chitosan by standing, precipitation, suction filtration, drying, and recrystallization.

[0088] The preparation method of the above cream comprises the following steps:

[0089] Step S1, adding liquid paraffin, stearic acid, glyceryl monostearate, and lanolin into an oil phase container, heating until completely dissolved, and stirring evenly;

[0090] Step S2, adding a portion of deionized water into the water phase container A, adding the extract of Herba Citri Reticulatae, the extract of Fructus Kochiae, the extract of Stellera Chamaejasme, and the extract of Solidago asiatica, heating, stirring until completely dissolved, and then adding glycerin and stirring evenly;

[0091] Step S3, adding the remaining deionized water into another aqueous phase container B, adding chitosan, sodium hyaluronate, borneol, allantoin, menthol, and mechanically stirring until completely dissolved;

[0092] Step S4, adding the liquid in the oil phase container to the water phase container A under stirring, and then sequentially adding the liquid in the water phase container B and tocopherol acetate, and continuing stirring;

[0093] Step S5, homogenizing the mixture obtained in step S4;

[0094] Step S6, adding methylparaben and essence to the homogenized mixture, continuing stirring, discharging, and obtaining the cream;

[0095] In step S1, the heating temperature is 80-90°C;

[0096] In step S2, the heating temperature is 60-70°C;

[0097] In step S2, 3 / 5 of deionized water is added, and in step S3, the remaining 2 / 5 of deionized water is added;

[0098] In the step S3, the mixture is kept warm at 70-80° C. after being completely dissolved;

[0099] In step S5, the temperature is lowered to 45-55° C. and homogenized for 5-10 minutes.

[0100] Comparative Example 1

[0101] This comparative example uses ordinary chitosan with a deacetylation degree of 90%, CAS number: 9012-76-4, and a molecular weight of 150,000. Modified chitosan, ie, the chitosan before modification in other examples 1-3, is not used. The rest is the same as in example 2.

[0102] Comparative Example 2

[0103] This comparative example does not contain the extract of Potentilla fruticosa, and is otherwise the same as Example 2.

[0104] Comparative Example 3

[0105] This comparative example does not contain Kochia scoparia fruit extract, and the rest is the same as Example 2.

[0106] Comparative Example 4

[0107] This comparative example does not contain the wolfberry extract, and the other parts are the same as those in Example 2.

[0108] Comparative Example 5

[0109] This comparative example does not contain Solidago sphaerocephala extract, and the rest is the same as Example 2.

[0110] Comparative Example 6

[0111] Commercially available retinoic acid cream (0.05%).

[0112] Test Example 1

[0113] This test example mainly tests the physicochemical properties of the ointments prepared in Examples 1-3.

[0114] 1. The creams prepared in Examples 1-3 were placed in a 50°C thermostat for 48 hours. It was found that the prepared creams remained uniform and stable without stratification, indicating that the creams prepared in the present invention have thermal stability.

[0115] 2. The creams prepared in Examples 1-3 were placed in a centrifuge tube and centrifuged at 3000 rpm for 30 min. It was found that the prepared creams remained uniform and stable without stratification, indicating that the creams prepared in the present invention had good stability.

[0116] Test Example 2

[0117] This test example tests the improvement of acne vulgaris symptoms by Example 2 and Comparative Examples 1-6.

[0118] 210 female volunteers diagnosed with acne vulgaris, aged 20-40 years old, were randomly divided into 7 groups, 30 in each group. Use 0.1g twice a day, morning and evening, for 30 consecutive days; compare the number, size and color of acne before and after use.

[0119] Judging criteria:

[0120] Ineffective: No significant improvement in acne, or even worsening;

[0121] Slightly effective: There is no significant change in the number of acne, but the size becomes smaller and the color becomes lighter;

[0122] Effective: The number of acne is significantly reduced, the color becomes lighter, and it basically disappears.

[0123] The results are shown in Table 1.

[0124] Table 1 Therapeutic effects of acne vulgaris

[0125] Slightly effective efficient invalid Effectiveness (%) Example 2 10 13 7 76 Comparative Example 1 10 9 11 63 Comparative Example 2 9 8 13 56 Comparative Example 3 8 8 14 53 Comparative Example 4 9 9 12 60 Comparative Example 5 11 9 10 66 Comparative Example 6 5 21 4 86

[0126] The above results show that the present invention has a certain effect on acne vulgaris, but the effect is slightly worse than that of the commercially available retinoic acid cream (0.05%). However, the advantage of the present invention is that it basically does not contain western medicine and is green and natural.

[0127] Test Example 2

[0128] This test example tests the improvement of premenstrual acne symptoms by Example 2 and Comparative Examples 1-6.

[0129] 140 female volunteers diagnosed with premenstrual acne were selected, aged 20-40 years old, and randomly divided into 7 groups, 20 in each group. Used twice a day, morning and evening, 0.1g each time, for 45 consecutive days; the number, size, and color of menstrual acne before and after use were compared. The results are shown in Table 2.

[0130] Table 2 Improvement of premenstrual acne symptoms

[0131]

[0132]

[0133] According to the data in the above table, and Figure 1 and Figure 2 It can be seen that Example 2 with a Herba Citri Reticulatae Extract, a Fructus Kochiae Extract, a Stellera Chamaejasme Extract and a Solidago asiatica Extract has the best effective rate, and after the modified chitosan therein is changed to chitosan, the effective rate decreases, and it can be inferred that the modified chitosan also has an increasing effect on the therapeutic effect. It can be seen from Comparative Examples 2-5 that the removal of Herba Citri Reticulatae Extract, a Fructus Kochiae Extract, a Stellera Chamaejasme Extract and a Solidago asiatica Extract, respectively, will cause a large decrease in the effective rate, and only a combination of use can achieve the best effect. It can be seen from Comparative Example 6 that although the efficacy of retinoic acid ointment for common acne is better than this cream, the effective rate for improving premenstrual acne symptoms is significantly lower than that of the cream described in the present invention. This point inspires us that the cream described in the present invention can be used in combination with retinoic acid to treat patients with common acne combined with premenstrual acne symptoms, which has a good industrial prospect.

[0134] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the above embodiments do not limit the present invention in any form, and any technical solution obtained by equivalent replacement or equivalent transformation falls within the protection scope of the present invention.

Claims

1. A cream for improving female premenstrual acne symptoms, characterized in that: The cream is composed of active ingredients and auxiliary materials, and the active ingredients are composed of the following raw materials: 18g of Herba Citri Reticulatae Extract, 15g of Kochia scoparia Extract, 7g of Wolfberry Extract, 4.5g of Solidago asiatica Extract, 4.5g of Modified Chitosan, 4.5g of Sodium Hyaluronate, 3g of Borneolum Syntheticum, 2.5g of Allantoin, 1.5g of Menthol, 0.8g of Tocopherol Acetate, and 0.8g of Methylparaben; The auxiliary materials are composed of the following raw materials by weight: 30g liquid paraffin, 18g glycerol, 16g stearic acid, 8g glyceryl monostearate, 5g lanolin, 1.5g essence, 55g deionized water; The Herba Citri Reticulatae Extract is prepared by the following steps: Fresh leaves of Potentilla fruticosa are squeezed for juice, and the juice is filtered through a 45 μm filter membrane, and the filtrate is concentrated by rotary evaporation to obtain a brown concentrate, which is then dried to obtain a brown powder, which is the Potentilla fruticosa extract; The modified chitosan is prepared by the following steps: Add 10g chitosan raw material to 15g 15% acetic acid solution, place in an ice-water bath, and control the reaction temperature at 0-5°C; add 3g lecithin and 1.5g hydroxypropyl distarch phosphate under stirring; remove the ice-water bath after the addition is complete, and continue stirring at 30-40°C for 4-8h; stand, precipitate, filter, dry, and recrystallize to obtain modified chitosan; The preparation method of the above cream comprises the following steps: Step S1, adding liquid paraffin, stearic acid, glyceryl monostearate, and lanolin into an oil phase container, heating until completely dissolved, and stirring evenly; Step S2, adding a portion of deionized water into the water phase container A, adding the extract of Herba Citri Reticulatae, the extract of Fructus Kochiae, the extract of Stellera Chamaejasme, and the extract of Solidago asiatica, heating, stirring until completely dissolved, and then adding glycerin and stirring evenly; Step S3, adding the remaining deionized water into another aqueous phase container B, adding chitosan, sodium hyaluronate, borneol, allantoin, menthol, and mechanically stirring until completely dissolved; Step S4, adding the liquid in the oil phase container to the water phase container A under stirring, and then sequentially adding the liquid in the water phase container B and tocopherol acetate, and continuing stirring; Step S5, homogenizing the mixture obtained in step S4; Step S6, adding methylparaben and essence to the homogenized mixture, continuing stirring, discharging, and obtaining the cream; In step S1, the heating temperature is 80-90°C; In step S2, the heating temperature is 60-70°C; In step S2, 3 / 5 of deionized water is added, and in step S3, the remaining 2 / 5 of deionized water is added; In the step S3, the mixture is kept warm at 70-80° C. after being completely dissolved; In step S5, the temperature is lowered to 45-55° C. and homogenized for 5-10 minutes.

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