A kit storage mechanism
By designing a reagent kit storage mechanism with a rotating and shaking mechanism, the problems of uneven shaking and magnetic bead precipitation in the existing technology are solved, low-temperature storage and convenient operation are achieved, and the detection efficiency and result accuracy are improved.
Patent Information
- Application Number
- CN202111634952.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2021-12-29
- Publication Date
- 2025-10-10
- Estimated Expiration
- 2041-12-29
AI Technical Summary
The reagent kit storage mechanism of existing biochemical analyzers has problems such as high destructiveness, uneven shaking and magnetic bead precipitation during shaking, which affects the accuracy and stability of test results.
A reagent kit storage mechanism was designed, which includes a reagent compartment body, a cover and a base. It adopts a rotation and shaking mechanism, realizes the rotation and self-rotation of the reagent kit through gear transmission, and combines with the door drive to realize automatic opening and closing, ensuring that the magnetic beads remain free.
It realizes low-temperature storage, convenient access and replacement of test kits, improves detection efficiency, ensures the uniformity of magnetic beads in the test kit and the accuracy of test results, and reduces operation time.
Smart Images

Figure CN116409524B_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of biochemical immunoassay equipment, and in particular to a reagent box storage mechanism used in a biochemical immunoassay all-in-one machine. Background Art
[0002] Biochemical analysis is a common and important tool in clinical diagnosis. By analyzing blood or other body fluids to measure various biochemical indicators and combining them with other clinical data for comprehensive analysis, it can help diagnose diseases, evaluate organ function, identify complications, and determine the basis for future treatment. Biochemical analyzers are primarily used for quantitative determination of biochemical and chemical components of clinical blood and other body fluid samples, such as hemoglobin, cholesterol, triglycerides, albumin, C-reactive protein, glucose, potassium, sodium, and calcium. They are one of the most commonly used instruments in clinical analysis.
[0003] In the biochemical analysis process, reagents are used to react with samples to produce test reactants for clinical observation. The storage mechanism of the reagents has high requirements, that is, low-temperature storage is generally required, and it is necessary to facilitate the operation of reagent retrieval, replacement, and addition. At the same time, since the magnetic beads in the reagent are prone to precipitation when left unmoved for a long time, affecting the concentration of the magnetic beads in the reagent, in order to improve the accuracy and stability of the reagent test results, the magnetic beads in the reagent need to be mixed, so the test kit storage mechanism also needs to have a shaking function. In the existing technology, the fully automatic test kit storage mechanism usually shakes the test agent by shaking the entire test kit. This shaking method has the following disadvantages: 1. The shaking amplitude is large, which is easy to cause certain damage to the test kit itself; 2. The overall shaking is uneven for each test agent, that is, the uniformity of the shaking cannot be guaranteed for the test agent, making the test agent in poor condition. Summary of the Invention
[0004] In view of this, an object of the present invention is to provide a reagent kit storage mechanism to solve the problems existing in the prior art.
[0005] In order to achieve the above object, the technical solution adopted by the present invention is:
[0006] The container is provided with a plurality of containers and a storage door, and the container is provided with a plurality of containers and a storage door.
[0007] Preferably, the storage door mechanism includes a movable plate, a door plate, a cover plate and a door body driving component, the top surface of the reagent compartment cover body is recessed with a movable groove, the bottom of the groove at both ends of the movable groove are respectively provided with the reagent reagent storage port and a circular driving through hole, the cover plate is arranged on the top of the movable groove and the movable plate is also movably arranged between the cover plate and the bottom of the movable groove, the cover plate is provided with a door panel movable through hole at the position corresponding to the reagent reagent storage port, the door panel covers the door panel movable through hole and its bottom is fixedly connected to the top surface of the movable plate, the door body driving component is arranged at the bottom of the reagent compartment cover body and passes through the circular driving through hole and is driven and connected to the movable plate to drive the movable plate to move back and forth in the movable groove so that the door panel covers or leaves the reagent reagent storage port.
[0008] Preferably, the door driving component includes a door driving motor, a motor fixing frame, and a turntable, the motor fixing frame is arranged at the bottom of the reagent chamber cover, the turntable is arranged between the motor fixing frame and the reagent chamber cover and a driving shaft is vertically arranged on its top surface corresponding to the circumferential side of the circular driving through hole, the door driving motor is fixed to the bottom of the motor fixing frame and its output shaft passes through the motor fixing frame and is driven and connected at the center position of the circle of the turntable, the movable plate is provided with an elongated transmission hole at the position corresponding to the circular driving through hole, the top end of the driving shaft passes through the circular driving through hole and is placed in the elongated transmission hole, the door driving motor drives the turntable to rotate and causes the driving shaft on it to rotate along the circumferential side of the circular driving through hole and move along its length direction in the elongated transmission hole, so that the movable plate moves back and forth in the movable groove to drive the door panel to cover or leave the reagent reagent storage port.
[0009] Preferably, the reagent chamber is composed of an inner thermal insulation cover, an outer thermal insulation cover and a reagent chamber bottom plate, the inner thermal insulation cover and the outer thermal insulation cover are both arranged on the reagent chamber bottom plate and are coaxially arranged, the reagent tray is a ring-shaped structure and is placed between the inner thermal insulation cover and the outer thermal insulation cover, the top surface of the reagent chamber bottom plate is evenly provided with a plurality of reagent tray support seats along the circumference of the reagent tray, the reagent tray support seat includes an L-shaped base, a cantilever shaft and a support roller, the L-shaped base is vertically arranged on the reagent chamber bottom plate and the cantilever shaft is fixed radially along the reagent tray at the center position of the side on which it is not fixed to the reagent chamber bottom plate, the support roller is passed through the cantilever shaft through a bearing, the bottom surface of the reagent tray is in contact with the circumferential side surfaces of the plurality of support rollers so as to be rotatably arranged on the reagent chamber bottom plate.
[0010] Preferably, the placement rack is composed of two wedge-shaped positioning blocks, and two adjacent placement racks share one wedge-shaped positioning block. Both sides of the wedge-shaped positioning block are provided with guide grooves, and the wedge-shaped positioning blocks contained in multiple groups of the placement racks are evenly arranged along the circumferential direction of the reagent disk, and multiple groups of reagent kits are arranged and placed in two adjacent wedge-shaped positioning blocks.
[0011] Preferably, the rotating mechanism includes a rotating drive member and a rotating disk. The rotating disk is a ring-shaped structure and is fixed to the bottom of the reagent disk. A plurality of rotating teeth are evenly arranged on the inner circumferential side surface of the rotating disk. The rotating drive member includes a rotating motor base, a rotating motor, a transmission assembly, a rotating shaft and a rotating gear. The rotating motor base is fixed to the reagent compartment base and is vertically provided with a plurality of auxiliary support shafts and fixedly connected to the bottom surface of the reagent compartment bottom plate. The rotating shaft is vertically arranged on the rotating motor base through a shaft fixing seat. The top of the rotating shaft passes through the reagent compartment bottom plate and extends into the interior of the reagent compartment. The top of the rotating shaft is coaxially fixed with the rotating gear and the rotating gear is meshed with the plurality of rotating teeth on the rotating disk. The rotating motor is arranged on the rotating motor base and its output shaft is drivenly connected to the end of the rotating shaft to which the rotating gear is not fixed through the transmission assembly to drive the rotating shaft to rotate and through the meshing transmission of the rotating gear and the rotating teeth, the reagent tray drives the multiple groups of the placement racks thereon to rotate along the circumferential direction of the reagent tray.
[0012] Preferably, a ring-shaped guide block is fixed between the rotating disk and the reagent disk, and a plurality of movable guide members are evenly fixed on the bottom plate of the reagent chamber along the circumferential direction of the inner ring of the ring-shaped guide block, and the movable guide member includes a convex fixing seat and a movable guide wheel, the convex fixing seat is fixed on the bottom plate of the reagent chamber and the movable guide wheel is fixed on the top of the convex fixing seat through a bearing, the movable guide wheel is coaxially arranged with the reagent disk, the circumferential side surface of the movable guide wheel is tangent to the circumferential side surface of the inner ring of the ring-shaped guide block, and the top surface and bottom surface of the movable guide wheel are in contact with the bottom surface of the reagent disk and the top surface of the rotating disk respectively.
[0013] Preferably, the shaking mechanism includes a shaking drive member and a shaking turntable, the shaking turntable is a ring-shaped structure and is rotatably arranged at the inner circumference of the reagent disk through a connecting slide, a plurality of shaking rotating teeth are evenly arranged on the inner circumferential side surface of the shaking turntable, a plurality of transmission teeth are evenly arranged on the outer circumferential side surface of the shaking turntable, and a shaking gear is fixedly penetrated at the bottom of each shaking bracket and meshed with the transmission teeth on the shaking turntable, the shaking drive member includes a shaking motor base, a shaking motor, a transmission assembly, a shaking shaft and a shaking rotating gear, the shaking motor base is fixed on the reagent chamber base and is vertically provided with a plurality of auxiliary support shafts and fixedly connected to the bottom surface of the reagent chamber bottom plate, The shaking shaft is vertically arranged on the shaking motor base through an axis fixing seat, the top of the shaking shaft passes through the bottom plate of the reagent chamber and extends into the interior of the reagent chamber, the top of the shaking shaft is coaxially fixed with the shaking rotating gear and the shaking rotating gear is meshed with the multiple shaking rotating teeth on the shaking turntable, the shaking motor is arranged on the shaking motor base and its output shaft is driven and connected to the end of the shaking shaft that is not fixed with the shaking rotating gear through the transmission assembly to drive the shaking shaft to rotate and through the meshing of the shaking rotating gear and the shaking rotating teeth, and the meshing of the transmission teeth with the shaking gear at the bottom of each shaking bracket, so that the multiple shaking brackets rotate.
[0014] Preferably, a guide groove is recessed on the circumferential side surface of the inner ring of the shaking turntable, and a plurality of shaking guide members are evenly fixed on the bottom plate of the reagent chamber along the circumferential direction of the inner ring of the shaking turntable, and the shaking guide members include a convex guide seat and a shaking guide wheel, the convex guide seat is fixed on the bottom plate of the reagent chamber and the shaking guide wheel is fixed on the top of the convex guide seat through a bearing, the shaking guide wheel is coaxially arranged with the shaking turntable, the circumferential side surface of the shaking guide wheel is tangent to the bottom surface of the guide groove, and the top surface and bottom surface of the shaking guide wheel are in contact with the top surface groove wall and the bottom surface groove wall of the guide groove respectively.
[0015] Preferably, a refrigeration device, a support column and an insulation pad are also provided on the reagent chamber base, the support column is vertically arranged on the reagent chamber base, the reagent chamber body is fixed on the support column and the insulation pad is provided at the connection between the two, and the refrigeration device is fixed on the reagent chamber base and its top surface is in contact with the bottom surface of the reagent chamber body.
[0016] Compared with the prior art, the reagent kit storage mechanism provided by the present invention has the following advantages:
[0017] 1. The reagent kit storage mechanism meets a series of functions such as low-temperature storage, reagent retrieval and return, reagent replacement, and reagent addition. The reagent kit has a large storage capacity and can store a variety of reagents of various types and quantities. A single sample can be tested for multiple items, thereby improving detection efficiency.
[0018] 2. The reagent compartment cover can be opened and closed automatically through the transmission of a series of mechanical components, with a high degree of automation;
[0019] 3. By setting up a shaking mechanism, the storage of the reagent box body for the reagent box meets the requirements of the immunoassay principle, so that the magnetic beads / particles in the reagent box are always kept in a free state;
[0020] 4. To facilitate the removal and placement of reagent kits, a gear-driven rotation mechanism has been designed, allowing the kits to rotate around the center of the reagent compartment. When a kit is exhausted, the rotation mechanism rotates it to the kit storage port, allowing manual or robotic removal and placement of a new kit, further reducing operation time. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
[0022] Figure 1 A schematic diagram of the overall structure of a reagent kit storage mechanism provided by the present invention;
[0023] Figure 2 This is an exploded view of the reagent compartment cover;
[0024] Figure 3 Schematic diagram of the structure of the reagent compartment base;
[0025] Figure 4 It is a three-dimensional cross-sectional view of the internal structure of the reagent compartment body;
[0026] Figure 5 for Figure 4 Plane cross-sectional view after removing the placement rack;
[0027] Figure 6 for Figure 4 Schematic diagram after removing the inner insulation cover;
[0028] Figure 7 A planar cross-sectional view of the internal structure of the reagent compartment body from another viewing direction;
[0029] Figure 8 Schematic diagram of the structure of the reagent tray support;
[0030] Figure 9 It is a structural diagram of a wedge-shaped positioning block;
[0031] Figure 10 Schematic diagram of the structure of the reagent tray, wedge-shaped positioning block and reagent kit;
[0032] Figure 11 It is a structural diagram of the rotating mechanism;
[0033] Figure 12 Schematic diagram of the structure of the shaking mechanism;
[0034] Figure 13 It is a structural diagram of the shaking guide.
[0035] Description of reference numerals and components in the accompanying drawings:
[0036] 1. Reagent chamber body; 2. Reagent chamber cover; 3. Reagent chamber base; 4. Refrigeration device; 5. Support seat; 6. Insulation pad; 7. Reagent chamber storage port; 8. Movable plate; 9. Door panel; 10. Cover plate; 11. Movable slot; 12. Circular drive hole; 13. Door panel movable hole; 14. Door body drive motor; 15. Motor fixing bracket; 16. Turntable; 17. Drive shaft; 18. Long strip transmission hole; 19. Reagent tray; 20. Wedge-shaped positioning block; 21. Reagent chamber; 22. Diversion groove; 23. Shake bracket; 24. Inner insulation cover; 25. Outer insulation cover; 26. Reagent chamber bottom Plate; 27. Reagent disk support; 28. Rotating disk; 29. Rotating gear; 30. Rotating motor base; 31. Rotating motor; 32. Transmission assembly; 33. Rotating shaft; 34. Rotating gear; 35. Auxiliary support shaft; 36. Shaft fixing seat; 37. Ring-shaped guide block; 38. Moving guide member; 39. Shake turntable; 40. Shake rotating gear; 41. Transmission gear; 42. Shake gear; 43. Shake motor base; 44. Shake motor; 45. Shake shaft; 46. Shake transmission gear; 47. Guide groove; 48. Shake guide member; 49. Protrusion; 50. Heat insulation board;
[0037] 2701, L-shaped base; 2702, cantilever shaft; 2703, support roller; 3801, convex fixed seat; 3802, movable guide wheel; 4801, convex guide seat; 4802, shaking guide wheel. DETAILED DESCRIPTION
[0038] The technical solutions of the present invention will be clearly and completely described below through specific implementation methods. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.
[0039] See also Figures 1 to 13 As shown, a reagent box storage mechanism includes a reagent compartment body 1, a reagent compartment cover 2 and a reagent compartment base 3. The reagent compartment body 1 is fixed on the reagent compartment base 3 and its top surface is covered with a reagent compartment cover 2. In order to meet the requirements of low-temperature storage, a refrigeration device 4, a support column 5 and a thermal insulation pad 6 are also provided on the reagent compartment base 3, wherein the support column 5 is vertically arranged on the reagent compartment base 3, the refrigeration device 4 is fixed on the reagent compartment base 3 and its top surface is in contact with the bottom surface of the reagent compartment body 1. The main function of the refrigeration device 4 is to cool and cool the inside of the reagent compartment body 1 and control the temperature of the reagent box 21 within a suitable range. The reagent compartment body 1 is fixed on the support column 5 and an insulation pad 6 is provided at the connection between the two. The main function of providing the insulation pad 6 is to prevent the heat emitted by the refrigeration device 4 during refrigeration from being transferred upward from the support column 5 to the reagent compartment body 1, causing the refrigeration effect to deteriorate.
[0040] A reagent box storage port 7 is provided on the reagent compartment cover 2 and a storage door mechanism is provided on the reagent box storage port 7. The storage door mechanism includes a movable plate 8, a door plate 9, a cover plate 10 and a door body driving member. The top surface of the reagent compartment cover 2 is recessed with a movable groove 11, and the bottom of the groove at both ends of the movable groove 11 are respectively provided with a reagent box storage port 7 and a circular driving through hole 12. The cover plate 10 is covered on the top of the movable groove 11 and a gap is left between the cover plate 10 and the bottom of the movable groove 11 for moving the movable plate 8. The function of the cover plate 10 is to limit the movement of the movable plate 8 in its vertical direction. At the same time, a door plate movable through hole 13 is provided at the position of the cover plate 10 corresponding to the reagent box storage port 7. The door plate 9 covers the door plate movable through hole 13 and its bottom is fixedly connected to the top surface of the movable plate 8.
[0041] The door drive member is arranged at the bottom of the reagent compartment cover 2 and passes through the circular drive through-hole 12 to be driven and connected to the movable plate 8. Furthermore, the door drive member includes a door drive motor 14, a motor fixing frame 15, and a turntable 16. The motor fixing frame 15 is arranged at the bottom of the reagent compartment cover 2. The turntable 16 is arranged between the motor fixing frame 15 and the reagent compartment cover 2 and a drive shaft 17 is vertically arranged on the top surface thereof corresponding to the circumferential side of the circular drive through-hole 12. The door drive motor 14 is fixed to the bottom of the motor fixing frame 15 and its output shaft passes through the center position of the motor fixing frame 15 and is driven and connected to the turntable 16. A long strip transmission hole 18 is provided at the position of the movable plate 8 corresponding to the circular drive through-hole 12. The top end of the drive shaft 17 passes through the circular drive through-hole 12 and is placed in the long strip transmission hole 18. When the reagent box 21 needs to be taken out and placed, that is, when the reagent box storage port 7 needs to be exposed, the door drive motor 14 drives the turntable 16 to rotate, so that the drive shaft 17 on the turntable 16 rotates along the circumference of the circular drive through hole 12 and moves along its length direction in the long strip transmission hole 18, so as to convert the circular motion of the turntable 16 into the linear motion of the moving plate 8, so that the moving plate 8 moves back and forth in the moving groove 11 and drives the door panel 9 to cover or leave the reagent box storage port 7, thereby realizing the automatic opening and closing of the storage door mechanism.
[0042] In addition, a sensor (not shown) can be provided on the bottom surface of the reagent compartment cover 2 to read and record the basic information of the reagent kit 21. When the reagent kit 21 is exhausted, real-time feedback information can be provided to remind the staff to replace it in time.
[0043] The reagent bin body 1 includes a reagent bin chamber, a reagent tray 19, a shaking mechanism and a rotating mechanism. The reagent tray 19 is rotatably arranged at the bottom of the reagent bin chamber and a plurality of racks for placing reagent kits are arranged uniformly along its circumferential direction. Each rack is composed of two wedge-shaped positioning blocks 20. Two adjacent racks share one wedge-shaped positioning block 20. At the same time, both sides of each wedge-shaped positioning block 20 are provided with guide grooves 22. The reagent kit 21 is stored in a low-temperature environment and condensed water will condense on its surface. In order to prevent too much condensed water from adhering to its surface when the reagent kit 21 is placed or removed, a guide groove 22 is provided on the side of the wedge-shaped positioning block 20. In this way, during the process of taking out or putting in, the side of the reagent kit 21 will contact the side of the wedge-shaped positioning block 20, and most of the condensed water will be scraped away and discharged along the guide groove 22. The wedge-shaped positioning blocks 20 contained in the plurality of racks are uniformly arranged along the circumferential direction of the reagent tray 19, and a plurality of reagent kits 21 are arranged in two adjacent wedge-shaped positioning blocks 20. In addition, since the reagent box 21 is subjected to centrifugal motion when the reagent tray rotates, a protrusion 49 is provided at the bottom of the wedge-shaped positioning block 20 away from the center of the reagent tray 19 to prevent the reagent box 21 from flying out during rotation.
[0044] The rotating mechanism is arranged on the reagent bin base 3 and extends into the reagent bin main body 1 and is drivingly connected with the reagent disc 19, so that the reagent disc 19 drives the multiple groups of placing racks to rotate along the circumferential direction of the reagent disc 19. Meanwhile, each group of placing racks is rotatably provided with a uniforming support 23 at the position of the center of the reagent disc 19, and the uniforming mechanism is arranged on the reagent bin base 3 and extends into the reagent bin main body 1 and is drivingly connected with the multiple uniforming supports 23 to make the multiple uniforming supports 23 rotate.
[0045] The structure inside the reagent bin main body will be further described as follows:
[0046] The reagent bin cavity is composed of an inner heat preservation cover 24, an outer heat preservation cover 25 and a reagent bin bottom plate 26. The inner heat preservation cover 24 and the outer heat preservation cover 25 are arranged on the reagent bin bottom plate 26 and coaxially arranged, and together with the refrigerating device 4 on the reagent bin base 3 to ensure the low-temperature environment inside the reagent bin cavity. The reagent disc 19 is specially designed as a ring structure and is arranged between the inner heat preservation cover 24 and the outer heat preservation cover 25 to match the structural features of the two.
[0047] The top surface of the reagent bin bottom plate 26 is uniformly provided with multiple reagent disc support seats 27 along the circumferential direction of the reagent disc 19. The reagent disc support seat 27 comprises an L-shaped base 2701, a cantilever shaft 2702 and a support roller 2703. The L-shaped base 2701 is vertically arranged on the reagent bin bottom plate 26 and the cantilever shaft 2702 is fixed at the center position of the side of the L-shaped base 2701 which is not fixed to the reagent bin bottom plate 26 along the radial direction of the reagent disc 19. The support roller 2703 is arranged on the cantilever shaft 2702 through a bearing. The bottom surface of the reagent disc 19 is in contact with the circumferential surface of the multiple support rollers 2703, so that the reagent disc 19 can rotate relative to the reagent bin bottom plate 26, so as to be matched with the rotating mechanism to realize the rotation of the reagent disc 19.
[0048] In this embodiment, the rotating mechanism adopts a gear transmission mode. Specifically, the rotating mechanism comprises a rotating driving member and a rotating disc 28. The rotating disc 28 is designed as a ring structure to adapt to the internal structure of the reagent bin cavity and is fixed to the bottom of the reagent disc 19 as the rotating disc 19. Multiple rotating teeth 29 are uniformly arranged on the inner circumferential surface of the rotating disc 28.
[0049] Afterwards, the rotation drive member includes a rotation motor base 30, a rotation motor 31, a transmission assembly 32, a rotation shaft 33 and a rotation gear 34. The rotation motor base 30 is fixed on the reagent chamber base 3 and is vertically provided with multiple auxiliary support shafts 35 and is fixedly connected to the bottom surface of the reagent chamber base plate 26 to further support the reagent chamber main body 1. The rotation shaft 33 is vertically arranged on the rotation motor base 30 by an axle fixing seat 36, and the top of the rotation shaft 33 needs to penetrate the reagent chamber base plate 26 and extend into the reagent chamber inside and be coaxially fixed with a rotation gear 34 at its top, and this rotation gear 34 is meshed and connected with a plurality of rotation teeth 29 on the rotating disk 28. The rotation motor 31 is then arranged on the rotation motor base 30 and its output shaft is driven and connected to one end of the rotation shaft 33 that is not fixed with the rotation gear 34 through the transmission assembly 32.
[0050] When it is necessary to rotate the reagent tray 19 to rotate a reagent kit 21 thereon to the reagent kit storage port 7, the rotating motor 31 drives the rotating shaft 33 to rotate through the transmission assembly 32. The rotation of the rotating shaft 33 drives the rotating gear 34 on its top to rotate, thereby rotating the rotating disk 28 meshed with the rotating gear 34, so that the reagent tray 19 fixed on the rotating disk 28 can rotate relative to the reagent compartment bottom plate 26 under the action of the supporting roller 2703 of the reagent tray support seat 27, thereby driving the multiple groups of placement racks thereon to rotate along the circumferential direction of the reagent tray 19 and causing a specific corresponding reagent kit 21 to rotate to the reagent kit storage port 7. At this time, the door body drive motor 14 in the storage door mechanism is started, and through a series of mechanical transmissions, the movable plate 8 moves in the movable groove 11, and drives the door plate 9 to leave the reagent kit storage port 7 to expose the reagent kit storage port 7, which is convenient for reagent removal.
[0051] Because multiple reagent kits are placed on the reagent tray 19, the overall stability of the reagent tray 19 must be maintained during its rotation to prevent deviation. Therefore, a mechanism with a movable guide or limit function is specifically configured for the rotation mechanism. Specifically, a circular guide block 37 is fixedly disposed between the rotating disk 28 and the reagent tray 19. Multiple movable guide members 38 are evenly fixedly disposed on the reagent compartment base plate 26 along the inner circumference of the circular guide block 37. These movable guide members include a convex fixing seat 3801 and a movable guide wheel 3802. The convex fixing seat 3801 is fixed to the reagent compartment base plate 26, and a movable guide wheel 3802, coaxially arranged with the reagent tray 19, is fixed to its top via a bearing. To provide the movable guide or limit function, the circumferential side surfaces of the movable guide wheels 3802 must be tangential to the inner circumferential side surfaces of the circular guide block 37. Simultaneously, the top and bottom surfaces of the movable guide wheels 3802 must contact the bottom surface of the reagent tray 19 and the top surface of the rotating disk 28, respectively. The mutual restriction between the movable guide wheel 3802 and the circular guide block 37 ensures that the reagent disk 19 rotates smoothly.
[0052] Due to the requirements of the immunoassay principle, the magnetic beads / particles in the reagent kit 21 must always remain free, so the reagent kit 19 needs to be continuously shaken. Therefore, a shaking mechanism is also provided within the reagent compartment body 1. The shaking mechanism includes a shaking drive and a shaking turntable 39. Like the rotating disk 28, the shaking turntable 39 needs to be designed to adapt to the internal structure of the reagent compartment chamber. The ring-shaped structure is rotated by a connecting slide and is arranged on the inner circumference of the reagent tray 19.
[0053] The shake mechanism also uses a gear drive system. A plurality of shaker teeth 40 are evenly distributed on the inner circumference of the shaker disc 39, and a plurality of transmission teeth 41 are evenly distributed on the outer circumference of the shaker disc 39. A shaker gear 42 is fixedly mounted on the bottom of each shaker bracket 23 and meshes with the transmission teeth 41 on the shaker disc 39.
[0054] The shake drive comprises a shake motor base 43, a shake motor 44, a transmission assembly 32, a shake shaft 45, and a shake rotation gear 46. The shake motor base 43 is fixed to the reagent compartment base 3 and is vertically provided with multiple auxiliary support shafts 35 and fixedly connected to the bottom surface of the reagent compartment base plate 26 to further support the reagent compartment body 1. The shake shaft 45 is vertically arranged on the shake motor base 43 through an axle fixing seat 36. At the same time, the top of the shake shaft 45 passes through the reagent compartment base plate 26 and extends into the interior of the reagent compartment and is coaxially fixed with a shake rotation gear 46 at its top. The shake rotation gear 46 is meshed with multiple shake rotation teeth 40 on the shake turntable 39. The shake motor 44 is arranged on the shake motor base 43 and its output shaft is drivingly connected to the end of the shake shaft 45 not fixed with the shake rotation gear 46 through the transmission assembly 32.
[0055] Furthermore, a heat insulation plate 50 is also provided at the connection between the above-mentioned rotating shaft 33, the shaking shaft 45 and the bottom plate 26 of the reagent chamber. The main function of the heat insulation plate 50 is to prevent the cold air in the cavity from being transmitted downward along the rotating shaft 33 and the shaking shaft 45. Since the air at the bottom of the reagent chamber is hotter than the air inside the chamber, condensation water will form when encountering the colder rotating shaft 33 and the shaking shaft 45, and will adhere to them and flow downward, causing corrosion of the shaft body and the bearings inside the shaft fixing seat 36. Therefore, the heat insulation plate 50 is provided to avoid the above situation.
[0056] In order to keep the shaking bracket 23 driving the reagent to rotate at all times, the shaking motor 44 continuously drives the shaking shaft 45 to rotate, and the rotation of the shaking shaft 45 drives the shaking rotating gear 46 on its top to rotate, and then the shaking rotating gear 46 is engaged with the shaking rotating gear 40 and the transmission gear 41 is engaged with the shaking gear 42 at the bottom of each shaking bracket 23, so that multiple shaking brackets 23 rotate.
[0057] The shaking turntable 39 also needs to remain stable when rotating and avoid axial deflection. Therefore, similar to the rotating mechanism, a series of guide and limiting structures are also designed for the shaking turntable 39. Specifically, a guide groove 47 is recessed on the circumferential side of the inner ring of the shaking turntable 39, and a plurality of shaking guide members 48 are evenly fixed on the reagent compartment bottom plate 26 along the circumferential direction of the inner ring of the shaking turntable 39. The shaking guide members 48 include a convex guide seat 4801 and a shaking guide wheel 4802. The convex guide seat 4801 is fixed on the reagent compartment bottom plate 26 and a shaking guide wheel 4802 is fixed on its top through a bearing and is coaxially arranged with the shaking turntable 39. In order to play a guiding or limiting role, the circumferential side of the shaking guide wheel 4802 needs to be tangent to the bottom surface of the guide groove 47, and the top and bottom surfaces of the shaking guide wheel 4802 need to contact the top groove wall and bottom groove wall of the guide groove 47 respectively. By limiting the mutual position of the shaking guide wheel 4802 and the guide groove 47, the smooth rotation of the shaking turntable 39 is ensured, and each shaking bracket 23 can rotate on its own.
[0058] The above description of the disclosed embodiments will enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein, but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A reagent kit storage mechanism, characterized in that: The container is provided with a plurality of containers and a plurality of storage containers, and the container is provided with a plurality of containers and a plurality of storage containers, and the container is provided with a plurality of containers and a plurality of storage containers. The storage door mechanism includes a movable plate, a door plate, a cover plate and a door body driving component. The top surface of the reagent compartment cover body is recessed with a movable groove, and the bottom of the groove at both ends of the movable groove are respectively provided with the reagent reagent storage port and a circular driving through hole. The cover plate is arranged on the top of the movable groove and the movable plate is also movably arranged between the cover plate and the bottom of the movable groove. The cover plate is provided with a door panel movable through hole at the position corresponding to the reagent reagent storage port, the door panel covers the door panel movable through hole and its bottom is fixedly connected to the top surface of the movable plate, the door body driving component is arranged at the bottom of the reagent compartment cover body and passes through the circular driving through hole and is driven and connected to the movable plate to drive the movable plate to move back and forth in the movable groove so that the door panel covers or leaves the reagent reagent storage port.
2. A reagent kit storage mechanism according to claim 1, characterized in that: The door driving component includes a door driving motor, a motor fixing frame, and a turntable, wherein the motor fixing frame is arranged at the bottom of the reagent chamber cover, the turntable is arranged between the motor fixing frame and the reagent chamber cover, and a driving shaft is vertically arranged at the circumferential side of the top surface corresponding to the circular driving through hole, the door driving motor is fixed to the bottom of the motor fixing frame, and its output shaft passes through the motor fixing frame and is driven and connected at the center position of the turntable, the movable plate is provided with an elongated transmission hole at the position corresponding to the circular driving through hole, the top end of the driving shaft passes through the circular driving through hole and is placed in the elongated transmission hole, the door driving motor drives the turntable to rotate and causes the driving shaft on it to rotate along the circumferential side of the circular driving through hole and move along its length direction in the elongated transmission hole, so that the movable plate moves back and forth in the movable groove to drive the door panel to cover or leave the reagent reagent storage port.
3. A reagent kit storage mechanism according to claim 1, characterized in that: The reagent chamber is composed of an inner thermal insulation cover, an outer thermal insulation cover and a reagent chamber bottom plate. The inner thermal insulation cover and the outer thermal insulation cover are both arranged on the reagent chamber bottom plate and are coaxially arranged. The reagent tray is a ring-shaped structure and is placed between the inner thermal insulation cover and the outer thermal insulation cover. The top surface of the reagent chamber bottom plate is evenly provided with a plurality of reagent tray support seats along the circumference of the reagent tray. The reagent tray support seat includes an L-shaped base, a cantilever shaft and a support roller. The L-shaped base is vertically arranged on the reagent chamber bottom plate and the cantilever shaft is fixed radially along the reagent tray at the center position of the side thereof that is not fixed to the reagent chamber bottom plate. The support roller is passed through the cantilever shaft by a bearing. The bottom surface of the reagent tray contacts the circumferential side surfaces of the plurality of support rollers so as to be rotatably arranged on the reagent chamber bottom plate.
4. A reagent kit storage mechanism according to claim 3, characterized in that: The placement rack is composed of two wedge-shaped positioning blocks, and two adjacent placement racks share one wedge-shaped positioning block. Both sides of the wedge-shaped positioning block are provided with guide grooves. The wedge-shaped positioning blocks contained in multiple groups of the placement racks are evenly arranged along the circumferential direction of the reagent disk, and multiple groups of reagent kits are arranged and placed in two adjacent wedge-shaped positioning blocks.
5. The reagent kit storage mechanism according to claim 3, characterized in that: The rotating mechanism includes a rotating drive member and a rotating disk. The rotating disk is a ring-shaped structure and is fixed to the bottom of the reagent disk. A plurality of rotating teeth are evenly arranged on the inner circumferential side surface of the rotating disk. The rotating drive member includes a rotating motor base, a rotating motor, a transmission assembly, a rotating shaft and a rotating gear. The rotating motor base is fixed to the reagent compartment base and is vertically provided with a plurality of auxiliary support shafts and fixedly connected to the bottom surface of the reagent compartment bottom plate. The rotating shaft is vertically arranged on the rotating motor base through a shaft fixing seat. The top of the rotating shaft passes through the reagent compartment bottom plate and extends into the interior of the reagent compartment. The top of the rotating shaft is coaxially fixed with the rotating gear and the rotating gear is meshed with the plurality of rotating teeth on the rotating disk. The rotating motor is arranged on the rotating motor base and its output shaft is drivenly connected to the end of the rotating shaft not fixed with the rotating gear through the transmission assembly to drive the rotating shaft to rotate and through the meshing transmission of the rotating gear and the rotating teeth, the reagent tray drives the multiple groups of the placement racks thereon to rotate along the circumferential direction of the reagent tray.
6. A reagent kit storage mechanism according to claim 5, characterized in that: A circular guide block is also fixed between the rotating disk and the reagent disk. A plurality of movable guide members are evenly fixed on the bottom plate of the reagent chamber along the circumferential direction of the inner ring of the circular guide block. The movable guide member includes a convex fixing seat and a movable guide wheel. The convex fixing seat is fixed on the bottom plate of the reagent chamber and the movable guide wheel is fixed on the top of the convex fixing seat through a bearing. The movable guide wheel is coaxially arranged with the reagent disk. The circumferential side surface of the movable guide wheel is tangent to the circumferential side surface of the inner ring of the circular guide block. The top surface and bottom surface of the movable guide wheel are in contact with the bottom surface of the reagent disk and the top surface of the rotating disk respectively.
7. A reagent kit storage mechanism according to claim 3, characterized in that: The shaking mechanism includes a shaking drive component and a shaking turntable. The shaking turntable is a ring-shaped structure and is rotatably arranged at the inner circumference of the reagent disk through a connecting slide. A plurality of shaking rotating teeth are evenly arranged on the inner circumferential side surface of the shaking turntable, and a plurality of transmission teeth are evenly arranged on the outer circumferential side surface of the shaking turntable. A shaking gear is fixedly penetrated at the bottom of each shaking bracket and is meshed with the transmission teeth on the shaking turntable. The shaking drive component includes a shaking motor base, a shaking motor, a transmission assembly, a shaking shaft and a shaking rotating gear. The shaking motor base is fixed on the reagent bin base and is vertically provided with a plurality of auxiliary support shafts and fixedly connected to the bottom surface of the reagent bin bottom plate. The shaker shaft is vertically arranged on the shake motor base through an axis fixing seat, the top of the shaker shaft passes through the bottom plate of the reagent chamber and extends into the interior of the reagent chamber, the top of the shaker shaft is coaxially fixed with the shake rotating gear and the shake rotating gear is meshed with the multiple shake rotating teeth on the shake turntable, the shake motor is arranged on the shake motor base and its output shaft is driven and connected to the end of the shaker shaft that is not fixed with the shake rotating gear through the transmission assembly to drive the shaker shaft to rotate and through the meshing of the shake rotating gear and the shake rotating teeth, and the meshing of the transmission teeth with the shake gear at the bottom of each shake bracket, so that the multiple shake brackets rotate.
8. A reagent kit storage mechanism according to claim 7, characterized in that: A guide groove is recessed on the circumferential side surface of the inner ring of the shaking turntable, and a plurality of shaking guide members are evenly fixed on the bottom plate of the reagent chamber along the circumferential direction of the inner ring of the shaking turntable, and the shaking guide member includes a convex guide seat and a shaking guide wheel, the convex guide seat is fixed on the bottom plate of the reagent chamber and the shaking guide wheel is fixed on the top of the convex guide seat through a bearing, the shaking guide wheel is coaxially arranged with the shaking turntable, the circumferential side surface of the shaking guide wheel is tangent to the bottom surface of the guide groove, and the top surface and bottom surface of the shaking guide wheel are in contact with the top surface groove wall and the bottom surface groove wall of the guide groove respectively.
9. The reagent kit storage mechanism according to claim 1, characterized in that: The reagent chamber base is also provided with a refrigeration device, a support column and an insulation pad. The support column is vertically arranged on the reagent chamber base, the reagent chamber body is fixed on the support column and the insulation pad is provided at the connection between the two. The refrigeration device is fixed on the reagent chamber base and its top surface is in contact with the bottom surface of the reagent chamber body.
Citation Information
Patent Citations
Reagent refrigerating device
CN110961172A
Shaking mechanism for kit storage bin
CN217725326U