Silk absorbable barbed suture and its processing technology

Abstract

The present invention discloses a silk absorbable barbed suture and a processing technology, comprising a thread body with a proximal end and a distal end, the thread body comprising a thread body inner core and a thread body outer shell, the thread body inner core comprising at least two natural mulberry silks woven and twisted with each other, the thread body outer shell having biodegradability, biocompatibility and non-toxicity; the thread body having barbs, the barbs protruding from the thread body toward the proximal end or the distal end, the barbs forming an angle between the thread body surfaces, the barbs having an inner end and an outer end, the inner end and the outer end both being formed by inward cutting of the thread body outer shell. The thread body inner core and the thread body outer shell both have good biodegradability, biocompatibility and non-toxicity, reducing human discomfort, and the suture with barbs avoids problems such as knotting during suturing, can act on the wound for a long time, has strong comprehensive mechanical properties, can be effectively absorbed and degraded by the human body, and reduces wound inflammation and the like.

Description

Technical Field

[0001] The invention relates to an absorbable silk barbed suture thread and a processing technology thereof. Background Art

[0002] In the field of medical aesthetics, barbed sutures are often used in operations such as thread carving and face lifting. The tension generated by the barbs is used to lift and reposition aging, sagging soft tissues to achieve the effect of suturing.

[0003] Compared with conventional sutures, barbed sutures, which are usually made of the same material as conventional sutures, have more advantages in suturing wounds. Conventional sutures need to be knotted after surgery to complete the suturing and fixation of biological tissue wounds, which prolongs the operation time, increases the surgical risk, and also has problems such as biological rejection reactions.

[0004] Therefore, a new suture is needed that can not only achieve rapid suturing, but also avoid biological rejection reactions and achieve the purpose of being degradable. Summary of the Invention

[0005] The first purpose of the present invention is to provide a silk absorbable barbed suture, which has the advantages of good suturing effect, non-toxicity and absorbability.

[0006] The above technical objectives of the present invention are achieved through the following technical solutions: a silk absorbable barbed suture, comprising a thread body with a proximal end and a distal end, the thread body comprising a thread body inner core and a thread body outer shell, the thread body inner core comprising at least two natural mulberry silks woven and twisted with each other, the thread body outer shell having biodegradability, biocompatibility and non-toxicity; the thread body having barbs, the barbs protruding from the thread body to the proximal end or the distal end, the barbs forming an angle between the thread body surfaces, the barbs having an inner end and an outer end, the inner end and the outer end both being

[0007] It is formed by cutting the outer shell of the wire body inward.

[0008] Preferably, the inner core diameter of the wire body is 0.2-0.3 mm, and each group of the silk bundles is woven from at least two degummed natural mulberry silks.

[0009] Preferably, the depth of the barb is one quarter to one third of the diameter of the outer shell of the wire body, and the angle is 10 degrees to 170 degrees.

[0010] Preferably, the depth of the barb is one third of the diameter of the outer shell of the wire body, and the angle is 15 degrees.

[0011] Preferably, the thread has 11-14 barbs per centimeter of length.

[0012] Preferably, the spacing between the barbs is 0.8 mm.

[0013] Preferably, the barbs are distributed in a spiral shape along the length direction of the wire body, the spiral angle of the barbs is 60 degrees, 90 degrees or 120 degrees, and the diameter of the wire body shell is 0.53 mm.

[0014] Preferably, the barbs are oriented in the same direction along the length of the thread, and the spacing between adjacent thread bodies along the length of the thread is consistent.

[0015] Preferably, the contours of the inner and outer ends are arc-shaped, and the outer shell of the wire body is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer.

[0016] By adopting the above technical solution, the goals of biodegradability, biocompatibility and non-toxicity are achieved.

[0017] The second object of the present invention is to provide a processing technology for absorbable silk barbed sutures.

[0018] The above technical objectives of the present invention are achieved through the following technical solutions: A processing technology for absorbable silk barbed sutures, comprising the following steps:

[0019] Step 1: Weaving a silk braided thread, interweaving and twisting multiple strands of natural silk to obtain a silk braided thread with a diameter of 0.2 mm to 0.3 mm;

[0020] Step 2: Degumming the silk braided yarn: immersing the silk braided yarn in a heated degumming agent, then taking out the silk braided yarn, washing the degummed silk braided yarn with water, repeating the degumming and washing 3-6 times, and then drying the silk braided yarn;

[0021] Step 3: Preparation of the inner core of the wire body: Winding multiple strands of silk braided wire to obtain the inner core of the wire body;

[0022] Step 4: Coating the wire body shell: melting the medical degradable material by heating, so that the medical degradable material coats the inner core of the wire body, and removing excess degradable material from the inner core of the wire body through the hole of the fixture to obtain the inner core of the wire body coated with the wire body shell of the medical degradable material;

[0023] Step 5: Cooling the outer shell of the wire body by air cooling or water cooling the outer shell of the wire body to dissipate heat and reduce temperature;

[0024] Step 6: Preparation of barbs: The outer shell of the thread body is formed with barbs on the surface through a gear cutting machine to obtain a silk absorbable barbed suture thread.

[0025] In summary, the inner core of the suture body is made of natural mulberry silk, and the outer shell of the suture body is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer. Both the inner core and the outer shell of the suture body have good biodegradability, biocompatibility and non-toxicity, reducing human discomfort. At the same time, the suture line with barbs avoids problems such as knotting during suture, can act on the wound for a long time, has strong comprehensive mechanical properties, can be effectively absorbed and degraded by the human body, and reduces wound inflammation. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 is a schematic cross-sectional view of Example 1;

[0027] Figure 2 Schematic diagram of the structure of the barb position in Example 1;

[0028] In the figure, 1, inner core of the wire body; 2, outer shell of the wire body; 3, silk thread bundle; 4, barb; 41, inner end; 42, outer end. DETAILED DESCRIPTION

[0029] The present invention will be further described in detail below with reference to the accompanying drawings.

[0030] This specific embodiment is merely an explanation of the present invention and is not intended to limit the present invention. After reading this specification, those skilled in the art may make non-creative modifications to this embodiment as needed. However, as long as such modifications are within the scope of the claims of the present invention, they are protected by patent law.

[0031] Example 1:

[0032] like Figure 1 As shown, a silk absorbable barbed suture includes a thread body with a proximal end and a distal end, the thread body includes a thread inner core 1 and a thread outer shell 2, the thread inner core 1 includes at least two silk bundles 3 woven together, each group of silk bundles 3 is woven from at least two degummed natural mulberry silks, and the thread outer shell 2 is biodegradable, biocompatible and non-toxic.

[0033] Therefore, the material of the wire shell 2 is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer. In this embodiment 1, the wire shell 2 is made of PLA, that is, polylactic acid.

[0034] like Figure 2As shown, the wire body has barbs 4, the barbs 4 are oriented in the same direction in the length direction of the wire body, the spacing between adjacent wire bodies in the length direction of the wire body is consistent, the barbs 4 protrude from the wire body to the proximal end or distal end, the barbs 4 are spirally distributed along the length direction of the wire body, the barbs 4 form an angle between the surfaces of the wire body, the barbs 4 have an inner end 41 and an outer end 42, the inner end 41 and the outer end 42 are both formed by cutting the wire body shell 2 inward, and the contours of the inner end 41 and the outer end 42 are arc-shaped.

[0035] In Example 1, the parameters of the silk absorbable barbed suture are as follows: the inner core 1 of the suture body comprises three silk bundles 3 woven together, each group of silk bundles 3 is woven from three degummed natural mulberry silks, the diameter of the inner core 1 of the suture body is 0.3 mm, the depth of the barbs 4 is one-third of the diameter of the outer shell 2 of the suture body, the angle is 15 degrees, there are 11 barbs 4 per centimeter of the suture body, the spacing between the barbs 4 is 0.8 mm, the barbs 4 in Example 1 do not have a spiral angle, and the diameter of the outer shell 2 of the suture body is 0.58 mm.

[0036] The processing technology of Example 1 is a processing technology for a silk protein absorbable barbed suture, comprising the following steps:

[0037] Step 1: Weaving a silk braided thread, interweaving and twisting multiple strands of natural silk to obtain a silk braided thread with a diameter of 0.2 mm to 0.3 mm;

[0038] Step 2: Degumming the silk braided thread, immersing the silk braided thread in a heated degumming agent, then taking out the silk braided thread, washing the degummed silk braided thread with water, repeating the degumming and washing steps 6 times, and then drying the silk braided thread;

[0039] Step 3: Preparation of the inner core 1 of the wire body: Winding multiple strands of silk braided wire to obtain the inner core 1 of the wire body;

[0040] Step 4: Coating the wire shell 2: Melting the medical degradable material by heating, so that the medical degradable material coats the wire inner core 1. The wire inner core 1 passes through the jig hole to remove excess degradable material, thereby obtaining the wire inner core 1 coated with the wire shell 2 made of the medical degradable material;

[0041] Step 5: Cooling the wire housing 2: Cooling the wire housing 2 with air, i.e., cooling it naturally and then dissipating the heat;

[0042] Step 6: Preparation of barbs 4: The outer shell 2 of the thread body is formed with barbs 4 on the surface by a gear cutting machine to obtain a silk protein absorbable barbed 4 suture.

[0043] Example 2:

[0044] The difference between Example 2 and Example 1 lies in the difference in parameters and materials of the wire body shell 2. In Example 2, the parameters of the silk absorbable barbed suture are as follows: the wire body core 1 comprises two natural mulberry silks woven together, each group of silk bundles 3 is woven from two degummed natural mulberry silks, the diameter of the wire body core 1 is 0.2 mm, the depth of the barbs 4 is one-third of the diameter of the wire body shell 2, the angle is 20 degrees, there are 14 barbs 4 per centimeter of the wire body, the spacing between the barbs 4 is 0.8 mm, the spiral angle of the barbs 4 is 60 degrees, and the diameter of the wire body shell 2 is 0.5 mm.

[0045] The material of the wire shell 2 is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer. In this embodiment, the wire shell 2 is made of PCL, that is, poly ε-caprolactone.

[0046] Example 3:

[0047] The difference between Example 3 and Example 1 is that the parameters and the material of the wire shell 2 are different. In Example 3, the parameters of the silk absorbable barbed suture are as follows: the wire core 1 includes six silk bundles 3 formed by intertwining and braiding each other, each group of silk bundles 3 is braided by at least two degummed natural mulberry silks, the diameter of the wire core 1 is 0.25 mm, the depth of the barbs 4 is

[0048] The wire body shell 2 is one quarter of the diameter, the angle is 10 degrees, the wire body has 12 barbs 4 per centimeter of length, the spacing between the barbs 4 is 0.8 mm, the spiral angle of the barbs 4 is 90 degrees, and the diameter of the wire body shell 2 is 0.53 mm.

[0049] The material of the wire shell 2 is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer. In this embodiment, the wire shell 2 is made of polyester-PBS / PBSA.

[0050] Example 4:

[0051] In Example 4, the parameters of the silk absorbable barbed suture are as follows: the inner core 1 of the suture body contains three silk bundles 3 woven together, each group of silk bundles 3 is woven from at least two degummed natural mulberry silks, the diameter of the inner core 1 of the suture body is 0.3 mm, the depth of the barbs 4 is one-third of the diameter of the suture body outer shell 2, the angle is 15 degrees, there are 14 barbs 4 per centimeter of the suture body, the spacing between the barbs 4 is 0.8 mm, the spiral angle of the barbs 4 is 120 degrees, and the diameter of the suture body outer shell 2 is 0.62 mm.

[0052] The material of the wire shell 2 is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer. In this embodiment, the wire shell 2 is made of aliphatic aromatic copolyester.

[0053] Example 5:

[0054] In Example 5, the parameters of the silk absorbable barbed suture are as follows: the inner core 1 of the suture body comprises five silk bundles 3 woven together, each group of silk bundles 3 is woven from three degummed natural mulberry silks, the diameter of the inner core 1 of the suture body is 0.2 mm, the depth of the barbs 4 is 0.1 mm, and the inner core 1 of the suture body is 0.2 mm.

[0055] The wire body shell 2 is one third of the diameter, the angle is 15 degrees, the wire body has 14 barbs 4 per centimeter of length, the spacing between the barbs 4 is 0.8 mm, the spiral angle of the barbs 4 is 90 degrees, and the diameter of the wire body shell 2 is 0.57 mm.

[0056] The material of the wire shell 2 is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer. In this embodiment, the wire shell 2 is made of polyvinyl alcohol (PVA).

[0057] Example 6:

[0058] In Example 1, the parameters of the silk absorbable barbed suture are as follows: the inner core 1 of the suture body comprises three natural mulberry silks woven together, each group of silk bundles 3 is woven from at least two degummed natural mulberry silks, the diameter of the inner core 1 of the suture body is 0.27 mm, the depth of the barbs 4 is one-third of the diameter of the outer shell 2 of the suture body, the angle is 15 degrees, there are 11 barbs 4 per centimeter of the suture body, the spacing between the barbs 4 is 0.8 mm, the spiral angle of the barbs 4 is 120 degrees, and the diameter of the outer shell 2 of the suture body is 0.65 mm.

[0059] The material of the wire shell 2 is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer. In this embodiment, the wire shell 2 is made of poly ε-caprolactone.

[0060] Example 7:

[0061] In Example 1, the parameters of the silk absorbable barbed suture are as follows: the inner core 1 of the thread comprises three natural mulberry silks woven together, each group of silk bundles 3 is woven from at least two degummed natural mulberry silks, the diameter of the inner core 1 of the thread is 0.21 mm, and the inner core 1 of the thread is 0.21 mm.

[0062] The core 1 is composed of at least two strands of silk thread bundles 3, the depth of the barb 4 is one-third of the diameter of the wire shell 2, the angle is 15 degrees, there are 11-14 barbs 4 per centimeter of the wire body, the spacing between the barbs 4 is 0.8mm, the spiral angle of the barb 4 is 60 degrees, 90 degrees or 120 degrees, and the diameter of the wire shell 2 is 0.58mm.

[0063] The material of the wire shell 2 is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer. In this embodiment, the wire shell 2 is made of carbon dioxide copolymer.

[0064] Serial number Wire diameter (mm) Breaking strength / N,≥ Example 1 0.58 37 Example 2 0.5 30 Example 3 0.53 25 Example 4 0.62 45 Example 5 0.57 36 Example 6 0.65 42 Example 7 0.58 37

Claims

1. A silk absorbable barbed suture, characterized in that: The invention comprises a thread body having a proximal end and a distal end, wherein the thread body comprises an inner core (1) and an outer shell (2), wherein the inner core (1) comprises at least two silk bundles (3) formed by mutually twisting and weaving, and the outer shell (2) is biodegradable, biocompatible and non-toxic; the thread body has barbs (4), wherein the barbs (4) protrude from the thread body toward the proximal end or the distal end, and wherein the barbs (4) form an angle between the surfaces of the thread body, and wherein the barbs (4) have an inner end (41) and an outer end (42), wherein both the inner end (41) and the outer end (42) are formed by inward cutting of the outer shell (2); the diameter of the inner core (1) is 0.2-0.3 mm, and each group of the silk bundles (3) The invention is formed by weaving at least two degummed natural mulberry silks, the depth of the barbs (4) is one third of the diameter of the thread shell (2), the angle is 15 degrees, the barbs (4) are spirally distributed along the length direction of the thread body, the spiral angle of the barbs (4) is 60 degrees, 90 degrees or 120 degrees, the diameter of the thread shell (2) is 0.53 mm, the contours of the inner end (41) and the outer end (42) are arc-shaped, and the thread shell (2) is made of polylactic acid PLA or poly 3-hydroxyalkanoate PHA or poly ε-caprolactone PCL or polyester-PBS / PBSA or aliphatic aromatic copolyester or polyvinyl alcohol (PVA) or carbon dioxide copolymer.

2. The absorbable silk barbed suture according to claim 1, characterized in that: The thread has 11-14 barbs (4) per centimeter of length.

3. The absorbable silk barbed suture according to claim 2, characterized in that: The spacing between the barbs (4) is 0.8 mm.

4. The absorbable silk barbed suture according to claim 1, characterized in that: The barbs (4) are oriented in the same direction along the length of the line, and the spacing between adjacent lines along the length of the line is consistent.

5. A process for processing the absorbable silk barbed suture according to any one of claims 1 to 4, characterized in that: The method comprises the following steps: step 1, weaving a silk braided thread, interweaving and twisting a plurality of strands of natural silk to obtain a silk braided thread, wherein the diameter of the silk braided thread is 0.2 mm to 0.3 mm; Step 2: Degumming the silk braided yarn: immersing the silk braided yarn in a heated degumming agent, then taking out the silk braided yarn, washing the degummed silk braided yarn with water, repeating the degumming and washing 3-6 times, and then drying the silk braided yarn; Step 3: preparing the inner core (1) of the wire body, winding a plurality of strands of silk braided wire to obtain the inner core (1) of the wire body; Step 4: Coating the wire body shell (2): melting the medical degradable material by heating, so that the medical degradable material coats the wire body inner core (1); the wire body inner core (1) passes through the fixture hole to remove excess degradable material, and obtains the wire body inner core (1) coated with the medical degradable material wire body shell (2); Step 5: Cooling the wire body shell (2): cooling the wire body shell (2) by air cooling or water cooling to dissipate heat and reduce temperature; Step 6: Preparation of barbs (4): The outer shell of the thread body (2) is formed with barbs (4) on the surface by a gear cutting machine to obtain a silk absorbable barbed suture thread.

Images