A method for preparing a radionuclide wire source

Abstract

This invention relates to the field of nuclear medicine PET technology, and more particularly to a method for preparing a radionuclide beam source. The method includes: mixing addition-type liquid silicone rubber with a radionuclide to obtain a liquid mixture; placing the liquid mixture in a syringe and removing air bubbles; connecting the tip of the syringe needle to a hollow casing; filling the casing with the liquid mixture and sealing it; then curing and sealing by welding; the radionuclide includes one or more of Ge-68, Cs-137, Co-60, P-32, Sr-90, Y-90, Na-22, Na-24, Sr-89, Lu-177, and Rh-106. This invention provides a method for preparing a radionuclide beam source for nuclear medicine PET. 68 The manufacturing method of the Ge wire source features room temperature curing with no byproducts, uniformity without bubbles, and long-term use at temperatures ranging from -50 to 200 degrees Celsius, meeting [the requirements]. 68 Safety performance level requirements for Ge line sources.

Description

Technical Field

[0001] This invention relates to the field of nuclear medicine PET technology, and in particular to a method for preparing a radionuclide wire source. Background Technology

[0002] 68 Ge nuclides have a half-life of 270 days and mainly emit X-rays of 9.2-10.3 keV. Linear radioactive sources (hereinafter referred to as "Ge nuclides") are used to create these sources. 68 Ge-line source is widely used in nuclear medicine PET to correct attenuation. 68 Ge wire source consists of a core and an outer shell. The core is uniformly loaded with... 68 Solid forms of Ge nuclides include electroplated bodies, microspheres (such as ceramics, silica, silica gel particles, etc.), gels (epoxy resin, gelatin, polyethylene glycol), etc. The outer shell is usually stainless steel, which seals the nuclide to prevent contamination and leakage, and provides certain mechanical properties.

[0003] Production 68 Ge wire source methods can be categorized into electroplating, gelation, and adsorption methods based on the core preparation process. Electroplating is a complex process; for example, Girard TA et al. used cyanide-containing electroplating. 68 GeCu3 production generates radioactive wastewater. Colloidal methods, such as those used by ROY S et al., involve dissolving gelatin and polyethylene glycol upon heating. 68 Ge is made into a gel, but condensation and shrinkage can create pores, affecting uniformity. Furthermore, the gel has a low melting point (40-50 degrees Celsius), and high operating temperatures can lead to the formation of vapors or molten liquids, easily causing contamination. Fu Hongyu et al. studied a method for preparing epoxy resin, but this process involves heating to 70°C, which may generate bubbles, and the exothermic curing process of epoxy resin also affects the uniformity of the linear source. The adsorption method is described in invention CN101593567A. 68 The preparation methods of sealed radioactive sources, such as Ge, all require adsorption in a strong acid environment before filling, which is dangerous and the filling process may also result in uneven filling, affecting uniformity. Summary of the Invention

[0004] To address the aforementioned technical problems, this invention provides a method for preparing a radionuclide wire source.

[0005] The method for preparing a radionuclide beam source provided by the present invention includes: mixing addition-type liquid silicone rubber with a radionuclide to obtain a liquid mixture; placing the liquid mixture in a syringe and removing air bubbles; connecting the tip of the syringe to a hollow shell; filling the shell with the liquid mixture and sealing it; then curing and sealing the weld.

[0006] The present invention provides a method for manufacturing a radionuclide wire source for nuclear medicine PET, which uses room temperature curing addition-type liquid silicone rubber as a matrix, uniformly mixes radionuclides, has strong fluidity, can self-explode internal air bubbles, can be cured at room temperature, does not generate heat or by-products, and is dense after curing with uniform radionuclide distribution. The method is simple and efficient to operate, and the silicone body has excellent properties and can be used for a long time at temperatures from -50 to 200 degrees Celsius, meeting the safety performance requirements of the radionuclide wire source.

[0007] Preferably, the nuclide line source is 68 Ge wire source; preferably, the aforementioned 68 The preparation method of the Ge-line source includes: mixing 0.4–0.5 g of micro / nano particles with 0.1–0.5 ml of... 68 The radioactive solution of Ge is mixed, stirred, heated, dried, and then ground. The finely ground solid is then mixed and stirred with addition-type liquid silicone rubber.

[0008] Further preferably, the micro-nano particles include nano-sized silica, ceramic microparticles, titanium dioxide, aluminum oxide, calcium carbonate, or metal microparticles; preferably, nano-sized silica, wherein the particle size of the nano-sized silica is 1-50 nm.

[0009] This invention has found that the nano-sized silica particles used in the preparation process and raw material system of this invention can significantly improve the encapsulation of radionuclides and the mechanical properties of silica gel, thereby greatly enhancing... 68 The safety performance of Ge wire sources.

[0010] Preferably, this includes: 0.1–0.5 ml containing 68 The radioactive solution of Ge is heated while being stirred, dried, and then ground. The finely ground solid is then mixed with addition-type liquid silicone rubber.

[0011] According to the present invention, the addition-type liquid silicone can be a single component or a two-component component, and the proportion is not limited; preferably, a two-component addition-type liquid silicone is used, wherein the main components of the silicone rubber B component are the base rubber and the crosslinking agent, and the main components of the silicone rubber A component are the base rubber and the catalyst.

[0012] Further preferred, the finely ground solid is mixed with 1-5 mL of silicone rubber component B, stirred for 10-30 min, and then 1-5 mL of silicone rubber component A is added, and stirring is continued for 5-10 min.

[0013] Further optimization also includes first... 68 The radioactive solution of Ge is mixed sequentially with the emulsifier and silicone rubber B, and then mixed with silicone rubber A.

[0014] Preferably, the syringe is left to stand with the needle tip facing upwards for 5 to 30 minutes to eliminate air bubbles; preferably, it also includes using vacuum defoaming and / or adding a defoaming agent.

[0015] According to the present invention, the emulsifier and defoamer can be of types commonly used in the art, and the present invention does not limit the specific types and amounts.

[0016] A further preferred embodiment includes using a two-layer shell: after curing, the cured material contains... 68 The silicone gel body is inserted into a stainless steel shell and then sealed and welded.

[0017] Preferably, the sealing welding includes connecting gaskets and weld caps at both ends of the casing, and performing sealing welding using laser, argon arc, or electron beam.

[0018] Preferably, the shell is made of stainless steel, titanium alloy, aluminum alloy or polymer, with titanium alloy being the preferred material.

[0019] In a preferred embodiment, 0.4–0.5 g of 1–50 nm silica is reacted with a solution containing… 68 Mix 0.1–0.5 mL of a radioactive Ge solution while stirring and heating until completely dry. Transfer to a mortar and continue mixing and grinding. Add 1–5 mL of silicone rubber component B to the ground solid and stir for 10–30 min. Then add 1–5 mL of silicone rubber component A and continue stirring for 5–10 min to obtain a liquid mixture. Place the liquid mixture in a syringe with the needle pointing upwards and let it stand for 5–30 min to remove internal micro-air bubbles (vacuum defoaming or the addition of a defoaming agent can also be used). Connect the tip of the syringe needle to the hollow shell and squeeze the liquid until the shell is full. Then plug both ends of the shell and let it stand to cure for 4–24 h, or heat to 40–120 °C and hold for 2–30 min to complete the curing. After curing, add gaskets and welding caps to both ends of the shell and seal by welding (laser or argon arc).

[0020] The beneficial effects of the present invention are at least as follows: the present invention provides a PET scan for nuclear medicine. 68 The manufacturing method of Ge wire sources features room temperature curing with no byproducts, uniform nuclide distribution without bubbles, and long-term use at temperatures ranging from -50 to 200 degrees Celsius, better meeting the requirements. 68 Safety performance level requirements for Ge line sources. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of the embodiments of the invention clearer, the technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0022] Unless otherwise stated, the raw materials and reagents used in the following examples are commercially available products or can be prepared by known methods. Where specific techniques or conditions are not specified in the examples, they are performed using conventional methods or according to techniques or conditions described in the literature in this field, or according to product instructions. Reagents and instruments whose manufacturers are not specified are all conventional products that can be purchased from legitimate channels. In the embodiments of this invention, nuclides can be used... 32 Solution P is used instead, because both solutions are water-soluble and the volume difference is small. Therefore, in actual production, it is replaced with [the solution name is missing here]. 68 Ge nuclides.

[0023] The present invention will be further described below with reference to embodiments.

[0024] Example 1

[0025] The method for preparing a radionuclide beam source provided in this invention involves placing 0.5g of nano-silica with a particle size of 1-50nm into a reaction vessel, and then adding... 32 0.5 ml of radioactive P solution was heated while stirring until completely dry. To ensure thorough mixing, the solution was transferred to a mortar and ground further. 1 mL of silicone rubber component B (main components: base rubber and crosslinking agent) was added to the solid, and the mixture was stirred for 30 min. Then, 1 mL of silicone rubber component A (main components: base rubber and catalyst) was added, and the mixture was stirred for another 10 min. The liquid was transferred to a syringe with the needle tip facing upwards and allowed to stand for 20 min to eliminate any tiny air bubbles. The tip of the needle was then connected to the hollow casing. Liquid was squeezed until the casing was completely filled, and both ends of the casing were plugged. The mixture was allowed to cure for 24 h. After curing, gaskets and weld caps were added to both ends of the casing, and the casing was then laser-sealed.

[0026] Example 2

[0027] The method is the same as in Example 1, except that the contents are directly added... 68 The radioactive solution of Ge was heated while stirring until it was completely dry. It was then transferred to a mortar and mixed and ground finely. Silicone rubber component B was then added, and the downstream process was the same as in Example 1.

[0028] Example 3

[0029] The same method as in Example 1 was used, except that the radioactive solution was mixed with the emulsifier, then silicone rubber component B was added and stirred, and then silicone rubber A was added. The downstream process was the same as in Example 1.

[0030] Example 4

[0031] The method is the same as in Example 1, except that after curing, the cured radioactive silicone body is encased in a stainless steel shell and then welded and sealed, forming a two-layer shell.

[0032] The method for manufacturing a radionuclide beam source for nuclear medicine PET according to an embodiment of the present invention uses room temperature curing addition-type liquid silicone rubber as a matrix, and uniformly mixes radionuclides ( 68 Ge (Ge) exhibits high fluidity, self-expelling internal air bubbles, and solidifies at room temperature without exothermic reactions or byproducts. After solidification, it is dense with uniform nuclide distribution. The process is simple and efficient, with excellent nuclide coating properties and superior performance. It can be used long-term at temperatures ranging from -50 to 200 degrees Celsius, better meeting the needs of [unclear - likely referring to specific applications]. 68 Safety performance level requirements for Ge line sources.

[0033] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for preparing a radionuclide wire source, characterized in that, include: Addition-cured liquid silicone rubber is mixed with a radioactive nuclide to obtain a liquid mixture. The liquid mixture is placed in a syringe and air bubbles are removed. The tip of the syringe is connected to a hollow shell. The shell is filled with the liquid mixture and then sealed. The mixture is then cured and welded. The radioactive nuclide includes one or more of Ge-68, Cs-137, Co-60, P-32, Sr-90, Y-90, Na-22, Na-24, Sr-89, Lu-177, and Rh-106.

2. The method for preparing a radionuclide wire source according to claim 1, characterized in that, The nuclide source is 68 Ge line source; the aforementioned 68 The preparation method of the Ge-line source includes: mixing 0.4–0.5 g of micro / nano particles with 0.1–0.5 ml of... 68 The radioactive solution of Ge is mixed, stirred, heated, dried, and then ground. The finely ground solid is then mixed and stirred with addition-type liquid silicone rubber.

3. The method for preparing a radionuclide wire source according to claim 2, characterized in that, The micro / nano particles include nano-sized silica, ceramic microparticles, titanium dioxide, aluminum oxide, calcium carbonate, or metal microparticles; the particle size of the nano-sized silica is 1–50 nm.

4. The method for preparing a radionuclide wire source according to claim 1, characterized in that, include: Take 0.1-0.5 ml containing 68 The radioactive solution of Ge is heated while being stirred, dried, and then ground. The finely ground solid is then mixed with addition-type liquid silicone rubber.

5. The method for preparing a radionuclide wire source according to claim 4, characterized in that, Mix the finely ground solid with 1-5 mL of silicone rubber component B and stir for 10-30 min. Then add 1-5 mL of silicone rubber component A and continue stirring for 5-10 min.

6. The method for preparing a radionuclide wire source according to claim 5, characterized in that, This also includes first 68 The radioactive solution of Ge is mixed sequentially with the emulsifier and silicone rubber B, and then mixed with silicone rubber A.

7. The method for preparing a radionuclide wire source according to claim 1, characterized in that, This includes holding the syringe with the needle pointing upwards for 5 to 30 minutes to eliminate air bubbles; it also includes using vacuum defoaming and / or adding defoaming agents.

8. The method for preparing a radionuclide wire source according to claim 1, characterized in that, It also includes the use of a two-layer shell: after curing, the cured material will contain... 68 The silicone gel body is inserted into a stainless steel shell and then sealed and welded.

9. The method for preparing a radionuclide wire source according to claim 1, characterized in that, The sealing welding includes connecting gaskets and weld caps at both ends of the casing, and performing sealing welding using laser, argon arc, or electron beam.

10. The method for preparing a radionuclide wire source according to any one of claims 1-9, characterized in that, The casing material includes stainless steel, titanium alloy, aluminum alloy, or polymer.