A cooling and soothing composition and its application

Abstract

The present invention provides a cooling and / or soothing composition, comprising 0.01 to 0.3 parts of methyldiisopropylpropionamide and 0 to 13.1 parts of a cooling raw material; the cooling raw materials are one or more of cedar buds, eucommia ulmoides, lespedeza, or tetrahydropiperine. The present invention screens the compounding ingredients and proportions of methyldiisopropylpropionamide, optimizes the problem of the slow onset of the cooling sensation of methyldiisopropylpropionamide, significantly prolongs the duration of the cooling sensation, and the compounded composition has high universality and good compatibility. It can be dissolved in an aqueous system and does not require a high content of emulsifiers, solubilizers, or ethanol for auxiliary dissolution, thereby reducing damage to the skin. The composition also has good stability and is added to the system without the risk of precipitation or water-oil separation.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a cooling and soothing composition, a preparation method and application thereof. Background Art

[0002] As the most important organ in the human body, the skin is exposed to factors that may cause skin irritation every day. The surfactants, preservatives, and fragrances contained in many cleansers (such as hand sanitizers) are the most important irritants. Frequent cleansing can lead to a variety of adverse reactions such as skin lipid loss, decreased NMF, neurogenic inflammation, and paresthesia, resulting in symptoms such as burning, stinging, itching, and tightness.

[0003] Numerous studies have shown that cooling ingredients may help soothe sensitive skin. Menthol and methyl diisopropyl propionamide are the most commonly used ingredients in existing technologies. While menthol, as a cooling ingredient, offers a strong cooling effect, it is highly volatile, resulting in a short cooling effect. Furthermore, its cooling effect decreases rapidly with prolonged use and storage. While increasing the dosage of cooling agents is often used to extend the duration of the cooling effect, higher concentrations do not significantly improve the duration and can, in fact, cause skin irritation, leading to localized pain or even burning sensations.

[0004] Currently, most commercially available formulations use ingredients such as menthol and menthol derivatives. These are highly volatile and can provide an instantaneous, short-lasting cooling sensation, accelerating the onset of cooling. However, due to their poor solubility, menthol and menthol derivatives are typically dissolved in highly concentrated ethanol solutions, which can be harmful to the skin. Furthermore, in environments with high or low temperatures and high water content, they can suffer from defects such as crystallization and water-oil separation, leading to unstable product quality.

[0005] Therefore, it is particularly urgent to develop a composition that has simple ingredients and has both cooling and soothing effects. Summary of the Invention

[0006] In view of this, the present invention provides a cooling and soothing composition, which has a cooling and soothing effect.

[0007] In this application, the term "and / or" describes the association relationship between associated objects, indicating that three relationships may exist. For example, A and / or B can mean: A exists alone, A and B exist at the same time, and B exists alone. A and B can be singular or plural.

[0008] In this application, "at least one" means one or more, and "more than one" means two or more. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single or plural items.

[0009] The present invention firstly discovers that the methyl diisopropyl propionamide raw material having a cooling sensation can have a good soothing effect when used alone.

[0010] The present invention screens the compound components and proportions of methyl diisopropyl propionamide, optimizes the problem of slow onset of the cooling sensation of methyl diisopropyl propionamide, significantly prolongs the duration of the cooling sensation, and the compounded composition has high universality and good compatibility, can be dissolved in an aqueous system, does not require a high content of emulsifiers, solubilizers or ethanol for auxiliary dissolution, reduces damage to the skin, and has good stability. There is no risk of precipitation or water-oil separation when the composition is added to the system.

[0011] The present invention provides a cooling and / or soothing composition, comprising 0.01 to 0.3 parts of methyl diisopropyl propionamide and 0 to 13.1 parts of cooling raw materials; the cooling raw materials are one or more of cedar buds, eucommia ulmoides, lespedeza or tetrahydropiperine.

[0012] The cooling and / or soothing composition provided by the present invention comprises 0.025 parts of methyl diisopropyl propionamide.

[0013] The inventors surprisingly discovered that the cooling raw material methyl diisopropyl propionamide can have a good soothing effect when used alone.

[0014] The present invention further studies the cooling and soothing compound raw materials of methyl diisopropyl propionamide.

[0015] The cooling and / or soothing composition provided by the present invention comprises 0 to 13.1 parts of cooling raw materials, preferably 0.01 to 8.5 parts of cooling raw materials; the cooling raw materials are one or more of cedar buds, eucommia ulmoides, lespedeza or tetrahydropiperine.

[0016] At this time, the amount of tetrahydropiperine added is 0-0.1 wt%, preferably 0.03 wt%, the amount of Lespedeza lepidoptera added is 0-5 wt%, preferably 2.5 wt%, the amount of Cryptomeria japonica bud added is 0-3 wt%, preferably 1 wt%, and the amount of Eucommia ulmoides extract added is 0-5 wt%, preferably 5 wt%.

[0017] In some preferred embodiments of the present invention, the cooling raw materials are selected from two or more of cedar buds, eucommia ulmoides, lespedeza, or tetrahydropiperine.

[0018] The above two components may be a combination of cedar buds and eucommia ulmoides, a combination of cedar buds and lespedeza, a combination of eucommia ulmoides and lespedeza, a combination of cedar buds and tetrahydropiperine, a combination of eucommia ulmoides and tetrahydropiperine, or a combination of lespedeza and tetrahydropiperine;

[0019] In the above combination, a preferred embodiment is that the cooling raw material is a combination of one of Cryptomeria japonica buds, Eucommia ulmoides and Lespedeza chinensis and tetrahydropiperine.

[0020] In the above combination, the most preferred ratio of the components satisfies the mass ratio of Cryptomeria japonica bud, Eucommia ulmoides, Lespedeza chinensis or tetrahydropiperine of (1): (5): (2.5): (0.03).

[0021] In the most preferred embodiment of the present invention, the cooling raw material is selected from cedar buds, eucommia ulmoides, lespedeza and tetrahydropiperine.

[0022] Lespedeza capitata is a perennial herbaceous plant of the Leguminosae family originating from North America. It is cultivated in Europe, particularly in France. The Omaha and Ponca peoples used the stems as a cautery to treat rheumatism and neuralgia. The aerial parts of Lespedeza capitata have been extensively studied for their urological properties, particularly their diuretic and anti-azotemic properties. A recent study showed that an ethanolic extract of Lespedeza capitata induces the proliferation of fibroblasts and keratinocytes in vitro, inhibits collagenase, stimulates collagen synthesis in fibroblasts, and has a lipolytic effect.

[0023] Tetrahydropiperine is derived from the hydrogenation of piperine, an alkaloid found in black pepper or the fruit of the genus Piper nigrum. Besides its proven anticonvulsant, antiepileptic, analgesic, and antifly and insect repellent properties, it also significantly improves and promotes the absorption and utilization of active ingredients by skin tissue. It increases the fluidity of the lipid bilayer, facilitating the diffusion of drug and active ingredient molecules through the hydrocarbon sites of the lipid bilayer, and enhances the affinity of drug molecules for nutrients and cell membranes. This significantly facilitates the rapid penetration of active ingredients in pharmaceuticals and cosmetics through the skin. It is also an essential raw material and intermediate for a variety of pharmaceutical drugs.

[0024] Eucommia ulmoides is the sole species of the genus Eucommia, the only genus in the Eucommia family. In China, Eucommia bark has traditionally been used as an analgesic, tonic, and antihypertensive. Furthermore, the Compendium of Materia Medica describes fresh Eucommia leaves as "edible as a vegetable." Roasted fresh Eucommia leaves, called "Tochu-cha," are available in Japan as a beverage. They contain iridoid glycosides (genistin and fusin) and a caffeic acid derivative (chlorogenic acid). Furthermore, studies have shown that long-term consumption of fresh Eucommia leaf extract can lower systolic blood pressure. Modern research indicates that Eucommia ulmoides can remove waste from the body, enhance cellular metabolism, prevent musculoskeletal aging, balance blood pressure, decompose cholesterol, reduce body fat, restore vascular elasticity, act as a diuretic and heat-clearing agent, have broad-spectrum antibacterial properties, stimulate the central nervous system, and increase white blood cell counts. Cosmetic dosage: Commonly used in face creams, lotions, and serums.

[0025] The present invention further verifies that the above composition has good physical cooling and soothing effects, and further tests have found that the composition has an antipruritic effect.

[0026] The present invention provides use of any one of the compositions in preparing a cooling and / or soothing product.

[0027] According to the present invention, the soothing effect includes alleviating skin itching symptoms, improving skin tolerance and barrier function, and relieving stinging pain; the cooling effect is to reduce the skin surface temperature or activate the nerve receptor channel TRPM8.

[0028] The present invention does not limit the product, which may be a cosmetic, and its dosage form may be water, lotion, cream, etc.

[0029] The present invention provides a cooling and soothing product, comprising the composition described in any one of the above technical solutions.

[0030] In the above-mentioned product provided by the present invention, the weight percentage of the composition in the product is 0.01% to 13.4%, preferably 8.555%.

[0031] The product provided by the present invention is preferably a cosmetic, and the cosmetic is a skin cosmetic.

[0032] In some preferred embodiments of the present invention, water and the following raw materials in parts by weight are included:

[0033]

[0034] In some preferred embodiments of the present invention, water and the following raw materials in parts by weight are included:

[0035]

[0036]

[0037] The present invention provides a method for preparing a cooling and soothing product according to any one of the above technical solutions, comprising:

[0038] The base material and the composition according to any one of claims 1 to 3 are stirred and mixed to obtain the product.

[0039] The present invention does not limit the specific manner of mixing and stirring, which are well known to those skilled in the art. Preferably, the stirring speed is 800-900 rpm and the stirring time is 10-15 minutes.

[0040] The preparation of the base material of the present invention is preferably specifically as follows:

[0041] Glycerin, ammonium acryloyldimethyltaurate / VP copolymer, butylene glycol, carbomer 980, glyceryl polyether-26, glyceryl glucoside, 1,2-hexanediol, and p-hydroxyacetophenone are stirred and heated until uniformly dissolved, and then cooled to 60-65° C., arginine dissolved in deionized water and pre-dissolved methyl diisopropyl propionamide are added, and the mixture is stirred and dispersed uniformly, and then cooled to 40-45° C. to obtain a gel base.

[0042] The present invention provides a method for repairing skin, comprising: applying the composition described in any one of the above technical solutions to the skin.

[0043] The above application may specifically be coating.

[0044] This patented invention uses methyl diisopropyl propionamide, compounded with the plant ingredients tetrahydropiperine and Lespedeza, to not only enhance the cooling sensation but also synergistically enhance the soothing effect, achieving a mild cooling effect and relieving itching. It provides more gentle and natural options for cooling solutions. Compared with existing technologies, the invention has the following beneficial effects:

[0045] It was discovered for the first time that the cooling ingredient methyl diisopropyl propionamide can have a good soothing effect when used alone;

[0046] The compounding ingredients of methyl diisopropyl propionamide were screened and optimized to solve the problem of slow cooling effect of methyl diisopropyl propionamide, significantly extending the duration of the cooling effect. Furthermore, the compounded composition has high universality and good compatibility. It can be dissolved in aqueous systems and does not require high levels of emulsifiers, solubilizers, or ethanol for auxiliary dissolution, reducing damage to the skin. Furthermore, the composition is stable and there is no risk of precipitation or water-oil separation when added to the system.

[0047] The raw materials are all plant extracts, which are highly safe and less irritating. Compared with traditional cooling agents, they are gentler and more suitable for sensitive skin.

[0048] Compared with the prior art, the present invention provides a cooling and / or soothing composition, comprising 0.01 to 0.3 parts of methyldiisopropylpropionamide and 0 to 13.1 parts of a cooling raw material; the cooling raw materials are one or more of cedar buds, eucommia ulmoides, lespedeza, or tetrahydropiperine. The present invention screens the compounding ingredients and proportions of methyldiisopropylpropionamide, optimizes the problem of the slow onset of the cooling sensation of methyldiisopropylpropionamide, significantly prolongs the duration of the cooling sensation, and the compounded composition has high universality and good compatibility. It can be dissolved in an aqueous system and does not require a high content of emulsifiers, solubilizers, or ethanol for auxiliary dissolution, reducing damage to the skin. The composition is also stable and there is no risk of precipitation or water-oil separation when added to the system. DETAILED DESCRIPTION

[0049] The present invention provides a cooling and soothing composition, its preparation method and application. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to achieve it. It should be noted in particular that all similar replacements and modifications are obvious to those skilled in the art and they all fall within the scope of protection of the present invention. The method and application of the present invention have been described through preferred embodiments. Relevant personnel can obviously modify or appropriately change and combine the method and application of this article without departing from the content, spirit and scope of the present invention to implement and apply the technology of the present invention.

[0050] The raw materials used in the present invention are all common commercial products and can be purchased in the market.

[0051] To further illustrate the present invention, a cooling and soothing composition, a preparation method thereof and applications provided by the present invention are described in detail below with reference to examples.

[0052] Example

[0053] 1. Screening of cooling raw materials

[0054] Gel base formula (base)

[0055]

[0056]

[0057] Table 1: (The amount of addition is selected according to the characteristics of the raw materials and is added according to the normal effective amount)

[0058]

[0059]

[0060] 2 Experimental steps

[0061] ① Preparation of gel base: Based on 100 g, weigh 4 g glycerol, 0.4 g ammonium acryloyldimethyltaurate / VP copolymer, 3 g butylene glycol, 0.2 g carbomer 980, 4 g glycerol polyether-26, 2 g glyceryl glucoside, 0.6 g 1,2-hexanediol, and 0.5 g p-hydroxyacetophenone, stir and heat until uniformly dissolved, cool to about 65 ° C, add 0.7 g arginine dissolved in deionized water and pre-dissolved methyl diisopropyl propionamide, stir and disperse evenly, and cool to about 45 ° C to obtain a gel base.

[0062] ② Take out a certain amount of gel base and add the required cooling ingredients listed in Table 1. Fill with deionized water to 100%, stir at a speed of about 900 rpm for 10 minutes. This will give cooling gel samples numbered 1-10.

[0063] Table 2:

[0064]

[0065] Experimental Conclusion: The cooling scores of the four testers were averaged and the highest scores were selected: No. 3: Cryptomeria japonica bud extract, No. 4: Lespedeza bicolor, No. 5: Tetrahydropiperine, No. 6: Eucommia ulmoides extract, and No. 10: Hemoglobin. The aforementioned five solutions were further expanded for consumer trials. The test results showed that although No. 9 scored the same as No. 6, due to its oil content, it had significant shortcomings in formula stability, so further testing was not carried out.

[0066] 3. Expand consumer trial testing of cooling ingredients

[0067] Table 3: (Increased sample size of subjects)

[0068]

[0069] Experimental procedures

[0070] ① Preparation of gel base: Based on 100 g, weigh 4 g glycerol, 0.4 g ammonium acryloyldimethyltaurate / VP copolymer, 3 g butylene glycol, 0.2 g carbomer 980, 4 g glycerol polyether-26, 2 g glyceryl glucoside, 0.6 g 1,2-hexanediol, and 0.5 g p-hydroxyacetophenone, stir and heat until uniformly dissolved, cool to about 65 ° C, add 0.7 g arginine dissolved in deionized water and pre-dissolved methyl diisopropyl propionamide, stir and disperse evenly, and cool to about 45 ° C to obtain a gel base.

[0071] ② Take out a certain amount of gel base and add the required cooling ingredients listed in Table 3. Fill with deionized water to 100%. Stir at a speed of about 900 rpm for 10 minutes. This will give cooling gel samples numbered 1-6.

[0072] Experimental report:

[0073] Comprehensive score conclusion (face):

[0074] In terms of cooling speed perception: No. 2 > No. 5 > No. 3 > No. 6 > No. 1

[0075] In terms of cooling intensity: No. 2 > No. 5 > No. 3 > No. 6 > No. 1

[0076] In terms of cooling duration perception: No. 2 > No. 3 > No. 6 > No. 5 > No. 1

[0077] Experimental Conclusion: The ranking method revealed the following results: ② > ③ ⑥ ⑤ > ①, indicating that Tetrahydropiperine (2), Eucommia ulmoides (3), Cryptomeria japonica (5), and Lespedeza bicolor (6) exhibited significant cooling effects. Hemoglobin (4) was excluded due to irritation reported by some consumers.

[0078] 4. Zebrafish Validation Test

[0079] Experimental design (to ensure the consistency of the total amount of effective substances)

[0080] Based on human testing, several ingredients with cooling effects were used, including tetrahydropiperine, eucommia extract, cryptomeria japonica bud extract, and Lespedeza bicolor. Experiments were conducted on the inhibition rate of TRPV1 in zebrafish to relieve stinging pain. The TRPV1 inhibition rate of individual ingredients was tested, as well as the combination of two ingredients to see if there was a synergistic effect. The specific experimental plan is shown in Table 4 below:

[0081] Table 4: Methyl diisopropyl propionamide (abbreviated as WS23)

[0082]

[0083] Experimental procedures

[0084] ① Preparation of gel base: Based on 100 g, weigh 4 g glycerol, 0.4 g ammonium acryloyldimethyltaurate / VP copolymer, 3 g butylene glycol, 0.2 g carbomer 980, 4 g glycerol polyether-26, 2 g glyceryl glucoside, 0.6 g 1,2-hexanediol, and 0.5 g p-hydroxyacetophenone, stir and heat until uniformly dissolved, cool to about 65 ° C, add 0.7 g arginine dissolved in deionized water and pre-dissolved methyl diisopropyl propionamide, stir and disperse evenly, and cool to about 45 ° C to obtain a gel base.

[0085] ② Take out a certain amount of gel base and add the required cooling raw materials or cooling raw material combination, and make up to 100% with deionized water, stirring at a speed of about 900 rpm, stirring time: 10 minutes.

[0086] ③ After packaging, conduct third-party zebrafish testing.

[0087] Experimental results

[0088] The test results of zebrafish samples are as follows: the raw material W23 (methyl diisopropyl propionamide) has the effect of soothing stinging, and adding raw materials or raw material combinations based on W23 can increase the inhibition rate of TRPV1 and have a soothing effect. Specific results are shown in Table 5:

[0089] Table 5:

[0090]

[0091]

[0092] Experimental Conclusion

[0093] Several ingredients and combinations with cooling properties were screened for sting relief testing in zebrafish. This was validated by their ability to inhibit the TRPV1 pathway. The results showed that these cooling ingredients all had varying degrees of sting relief. The greater the reduction in distance traveled under high-temperature stimulation, the greater the soothing effect of the sample.

[0094] 1. By comparing the experimental results of base0 and base, it was found that WS-23 (methyl diisopropyl propionamide) has a soothing effect;

[0095] 2. By comparing the experimental results from B-1 to J, it was found that any two of Lespedeza, Piper methysticum, Eucommia ulmoides, and Cryptomeria japonica buds have a synergistic effect;

[0096] 3. The soothing effect of BASE+WS 23+Lespedeza, Piper, Eucommia, and Cryptomeria buds was also better than that of Lespedeza, Piper, Eucommia, and Cryptomeria buds alone or in combination.

[0097] 4. Among BASE + WS 23 + any two of Lespedeza, Piper methysticum, Eucommia ulmoides, and Cryptomeria japonica buds, the combination of any one of these with Piper methysticum was superior to the other two combinations. Combination J, which included all of the above components, exhibited the best synergistic effect.

[0098] Based on this, experimental scheme A-3 was screened and thermal imaging tests were conducted to further verify the cooling effect of the cooling gel A-3.

[0099] 5. Thermal imaging verification experiment

[0100] Experimental design:

[0101] Thermal imaging human test: Using thermal imaging, we observed changes in facial temperature before and after using the product to determine whether the composition would affect skin temperature. The blank control was the basic formula tested on zebrafish, and the test formula was the basic formula tested on zebrafish plus the cooling composition Lespedeza chinensis + Tetrahydropiperine. The specific formula is shown in Table 6:

[0102] Table 6:

[0103] Experimental plan control group Cool 01 W-23 0 0.025％ Tetrahydropiperine 0 0.03％ Lespedeza 0 2.5％

[0104] Experimental procedures

[0105] Preparation of control group samples: Based on 100 g, weigh 4 g glycerol, 0.4 g ammonium acryloyldimethyltaurate / VP copolymer, 3 g butylene glycol, 0.2 g carbomer 980, 4 g glycerol polyether-26, 2 g glyceryl glucoside, 0.6 g 1,2-hexanediol, and 0.5 g p-hydroxyacetophenone, stir and heat until uniformly dissolved, cool to about 65 ° C, add 0.7 g arginine dissolved in deionized water, stir and disperse evenly, and cool to about 45 ° C for use.

[0106] Preparation of Cool 01:

[0107] ① Preparation of gel base: Based on 100 g, weigh 4 g glycerol, 0.4 g ammonium acryloyldimethyltaurate / VP copolymer, 3 g butylene glycol, 0.2 g carbomer 980, 4 g glycerol polyether-26, 2 g glyceryl glucoside, 0.6 g 1,2-hexanediol, and 0.5 g p-hydroxyacetophenone, stir and heat until uniformly dissolved, cool to about 65 ° C, add 0.7 g arginine dissolved in deionized water and pre-dissolved methyl diisopropyl propionamide, stir and disperse evenly, and cool to about 45 ° C to obtain a gel base.

[0108] ② Take out a certain amount of gel base and add the required tetrahydropiperine and Lespedeza, and make up to 100% with deionized water, stir at a speed of about 900 rpm, and stir for 10 minutes.

[0109] ③Perform thermal imaging test after packaging.

[0110] How to use the sample:

[0111] Use a scraper or other tool to apply 10-15g of the product on half of the face, then compare the two halves of the face. Leave it on for 10 minutes, then wipe it off gently with a cotton towel and measure the temperature.

[0112] Note: Avoid the eye and lip area

[0113] Frequency: One-time use.

[0114] Experimental results

[0115]

[0116] There was a significant difference in the degree of skin temperature reduction between the test samples and the blank control.

[0117] Experimental conclusion

[0118] The composition of methyl diisopropyl propionamide, tetrahydropiperine and Lespedeza has an obvious physical cooling effect on the skin.

[0119] 6. Animal histamine test

[0120] In order to further verify the soothing and antipruritic effects of the composition, a histamine experiment on mice was conducted.

[0121] Experimental animals: 50 ordinary guinea pigs, weighing 250 g-300 g, provided by Hunan Taiping Biotechnology Co., Ltd., experimental animal production license number: SCXK (Xiang) 2020-0005, and used after passing quarantine.

[0122] Animals were housed in single cages in the general area of ​​the animal room at a temperature of 21–23°C and a relative humidity of 57–59%. The experimental animal use license number is SYXK (Xiang) 2019-0016.

[0123] Feed: Provided by Hunan Taiping Biotechnology Co., Ltd., production license number: SCXK(Xiang)2018-0008.

[0124] Test Method: Fifty qualified guinea pigs, half male and half female, were randomly divided into five groups: a model group, a positive control group (fluocinonide cream group), a high-dose group (100% test substance content), a medium-dose group (50% test substance content), and a low-dose group (20% test substance content). Twenty-four hours before the test, the hair on the right hind paw and back of each guinea pig was shaved without damaging the epidermis. The corresponding drug was applied once at 0.1 mL per paw. The model group received an equal amount of normal saline. On the day of the experiment, the guinea pig's right hind paw and the shaved area on the back were abraded with sandpaper. The degree of abrasion should damage the epidermis but not the dermis, and the skin should bleed slightly. The abrasion area should be approximately 1 cm2. Topical medication should be applied once more. Ten minutes after the last application, 0.01% histamine phosphate was dripped onto the wound surface, starting with 0.05 mL per animal. Thereafter, the concentration was increased every 3 minutes by 0.01%, 0.02%, 0.03%, and 0.04%, with 0.05 mL added each time, until the guinea pig began to lick its right hind paw. The total amount of histamine phosphate at the time when the guinea pig began to lick its right hind paw was calculated, which was the itch-inducing zone.

[0125] Experimental Results: The results of the test substance's effects on histamine phosphate-induced pruritus in guinea pigs are shown in Table 7. Table 1 shows that compared with the model group, the high-dose test substance group had an inhibitory effect on histamine phosphate-induced pruritus in guinea pigs (P < 0.01). This indicates that the test substance can alleviate the pruritus symptoms caused by histamine phosphate and has a certain antipruritic effect, which may be related to improving skin tolerance and barrier function.

[0126] Table 7 Effects of the test substances on the itch response induced by histamine phosphate in guinea pigs (x±s)

[0127] Group Number of animals Itch-inducing domain (μg) Model Group 10 24.0±7.7 Fluocinolone group 10 96.5±43.5** High-dose group 10 72.5±31.6** Medium dose group 10 35.0±14.1 Low-dose group 10 29.5±12.8

[0128] Note: Compared with the model group, * indicates p < 0.05, ** indicates p < 0.01.

[0129] Summary: The composition provided by this patent not only has a cooling effect, but also has a soothing effect verified by zebrafish tests, and tetrahydropiperine and Lespedeza bicolor also have a synergistic soothing effect. In addition, the composition can significantly reduce the skin surface temperature and has an antipruritic effect according to animal histamine tests.

[0130] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A cooling and / or soothing composition, characterized in that The invention comprises 0.01 to 0.3 parts of methyl diisopropyl propionamide and 0.01 to 13.1 parts of a cooling material; the cooling material is a combination of at least one of cedar buds, eucommia ulmoides and lespedeza fruit and tetrahydropiperine.

2. The composition according to claim 1, characterized in that The cooling raw material is a combination of cedar buds, eucommia ulmoides, lespedeza and tetrahydropiperine, and the mass ratio of cedar buds, eucommia ulmoides, lespedeza and tetrahydropiperine is 1:5:2.5:0.

03.

3. The composition according to claim 1, characterized in that The invention comprises 0.025 parts of methyl diisopropyl propionamide, 0.03 parts of tetrahydropiperine and 2.5 parts of Lespedeza chinensis extract.

4. Use of the composition according to any one of claims 1 to 3 in the preparation of a cooling and / or soothing product.

5. The use according to claim 4, characterized in that The soothing effect includes alleviating skin itching symptoms, improving skin tolerance and barrier function, and soothing stinging; The cooling effect is to reduce the skin surface temperature or activate the nerve receptor channel TRPM8.

6. A cooling and soothing product, characterized in that The invention comprises a base material and the composition according to any one of claims 1 to 3.

7. The product according to claim 5, characterized in that The product comprises water and the following raw materials in parts by weight: 4 parts of glycerin; 3 parts of butanediol; 0.4 parts of ammonium acryloyldimethyltaurate / VP copolymer; 0.2 parts of Kapo 980; 4 parts of glyceryl ether-26; 2 parts of glyceryl glucoside; 0.6 parts of 1,2-hexanediol; 0.5 parts of p-hydroxyacetophenone; 0.7 parts of arginine; 0.01 to 13.4 parts of the composition according to any one of claims 1 to 3.

8. A method for preparing a cooling and soothing product, characterized in that: include: The base material and the composition according to any one of claims 1 to 3 are stirred and mixed to obtain the product.

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