A centrifugal separation device for biopharmaceuticals

Abstract

The present invention discloses a centrifugal separation device for biopharmaceuticals, which relates to the technical field of biopharmaceuticals and is characterized in that it includes: a feeding part, a test tube storage part, a tube plug opening part, a telescopic frame part, and a medicine taking part. The feeding part includes a bottom plate, on which a test tube conveyor belt is fixedly installed. There are several test tube clamps on the test tube conveyor belt. The centrifuge is placed on the bottom plate, and the motor shaft of the centrifugal motor inside the centrifuge is fixedly connected to the lower docking cylinder I; there are two test tube storage parts. When one test tube storage part stores test tubes, the other test tube storage part is placed on the lower docking cylinder I for centrifugal separation work; the tube plug opening part is fixedly installed on the bottom plate, and the test tube plug is opened through the tube plug opening part; the telescopic frame part is used to move the test tube storage part; the medicine taking part is fixedly installed on the bottom plate, and the medicine taking part is used to extract the liquid medicine at different heights in the separated test tubes. This device realizes integrated separation of the liquid medicine, with a fast speed and labor saving.

Description

Technical Field

[0001] The present invention relates to the technical field of biopharmaceuticals, and particularly to a centrifugal separation device for biopharmaceuticals. Background Art

[0002] High-speed centrifuges are widely used in scientific research, education, and production departments such as biology, chemistry, and medicine. They utilize the powerful centrifugal force generated by the high-speed rotation of the rotor to separate liquid from solid particles or each component in a liquid mixture. They are suitable for the rapid separation and synthesis of trace samples. By using the powerful centrifugal force generated by the centrifuge, it forces the particles in the solution to overcome diffusion and generate sedimentation motion. Centrifugation is to utilize the powerful centrifugal force generated by the high-speed rotation of the centrifuge rotor to accelerate the sedimentation speed of the particles in the liquid and separate substances with different sedimentation coefficients and buoyancy densities in the sample.

[0003] The Chinese utility model patent with the application number CN201921855634.X provides a centrifuge for biopharmaceuticals, including a centrifuge body. A base is installed at the bottom of the centrifuge body. Support feet are installed at both ends of the base. A shock-absorbing mechanism is installed between the support feet and the base. A shock-absorbing platform is installed at the top of the support feet. The centrifuge body is connected to the shock-absorbing platform, and a lifting hole is opened at the connection between the shock-absorbing platform and the centrifuge body. The radial dimension of the lifting hole is larger than the radial dimension of the centrifuge body. A driving motor is installed at the top of the base. The driving motor is located below the centrifuge body, and a lifting rod is installed at the output end of the driving motor. The end of the lifting rod opposite to the driving motor is installed on the driving motor, and a fixing seat is installed at the connection between the driving motor and the lifting rod. The mechanism of the present invention is simple and can effectively reduce the vibration and noise during the operation of the centrifuge.

[0004] Although the above-mentioned centrifuge for biopharmaceuticals solves the problems of large noise and large vibration during the high-speed rotation of the traditional centrifuge, each time it is used, it is necessary to manually put the liquid medicine into it, and the centrifugation time of the liquid medicine is relatively long. It always requires a special person to wait for the centrifugation to end and take away the liquid medicine. The operation is very cumbersome and very time-consuming and labor-intensive.

[0005] Currently, most of the biopharmaceutical centrifuges on the market basically require manual operation for loading and unloading, which is time-consuming and laborious. Therefore, it is necessary to invent a labor-saving centrifugal separation device for biopharmaceuticals that can automatically place test tubes. During the placement of test tubes, another test tube storage part inside the centrifugal separator can first perform centrifugal separation. After the centrifugation ends, the operation of separating and extracting the liquid medicine is carried out. When the test tubes on one turntable are all placed and need to be centrifuged, the liquid medicine in the test tubes on the other turntable has been extracted. The time for placing the test tubes is fully utilized, the work efficiency is improved, and it can extract liquid medicines with different layers, complete the layered separation of the liquid medicine, realize the full-automatic separation of the liquid medicine, save time, and reduce costs. Summary of the Invention

[0006] The technical solution adopted by the present invention is as follows: A centrifugal separation device for biopharmaceuticals, comprising: a feeding part, a test tube storage part, a tube plug opening part, a telescopic frame part, and a medicine taking part. The feeding part includes: a bottom plate, a test tube conveyor belt, a centrifugal separator, a lower docking cylinder I, and a moving test tube mechanism. The bottom plate is fixedly installed with a test tube conveyor belt, and several test tube clamps are provided on the test tube conveyor belt. An artificial person places the test tubes into the test tube clamps on the test tube conveyor belt. The centrifugal separator is placed on the bottom plate, and the upper cover of the centrifugal separator is a push-pull type cover. The motor shaft of the centrifugal motor inside the centrifugal separator is fixedly connected to the lower docking cylinder I. There are two test tube storage parts, and the two test tube storage parts are replaced. When one test tube storage part stores test tubes, the other test tube storage part is placed on the lower docking cylinder I for centrifugal separation work. The tube plug opening part is fixedly installed on the bottom plate, and the tube plug opening part is used to open the test tube plugs on the test tube storage part after centrifugal separation. The telescopic frame part is fixedly installed on the bottom plate, and the telescopic frame part is used to first move the test tube storage part after centrifugal separation to the middle position of the tube plug opening part, and then move the test tube storage part with the test tube plug removed to the lower part of the medicine taking part. The medicine taking part is fixedly installed on the bottom plate, and the medicine taking part is located on the side of the tube plug opening part. The medicine taking part is used to extract the liquid medicine at different heights in the separated test tubes.

[0007] Preferably, the feeding part further includes: a horizontal moving track and an electric cylinder. The horizontal moving track includes a bracket, a motor, a lead screw, and a slider. The bracket is fixedly installed on the bottom plate, the end of the bracket is fixedly installed with a motor, the shaft of the motor is fixedly connected to the lead screw, the lead screw is threadedly connected to the slider, the slider is slidably installed on the bracket, the slider is fixedly connected to the cylinder body of the electric cylinder, and the end of the piston rod of the electric cylinder is installed with a mechanical claw, and a push rod is provided at the middle position of the mechanical claw.

[0008] Preferably, the moving test tube mechanism of the feeding part includes: a motor I, a movable connecting rod, a rectangular plate, a sliding plate, and a sliding rod. The motor I is fixedly installed on the bracket on the bottom plate, the motor shaft of the motor I is fixedly connected to one end of the movable connecting rod, the other end of the movable connecting rod is rotatably connected to the sliding plate, the sliding plate is slidably installed on the rectangular plate, a V-shaped groove is provided on the sliding plate, the rectangular plate is fixedly installed on the bracket on the bottom plate, and a U-shaped groove is provided on the rectangular plate. The sliding rods are respectively slidably installed in the chutes of the rectangular plate and the sliding plate, and a mechanical claw is fixedly installed at the lower end of the sliding rod.

[0009] Preferably, the feeding part further includes: a rack, a gear I, a gear I bracket, a bevel gear I, a bevel gear II, a ratchet wheel, a gear II, and a lower docking cylinder II.

[0010] The upper end of the rack is fixedly installed at the rear end of the slide rod, and the rack is intermittently meshed with gear I. Gear I is rotatably installed on the gear I bracket, and the gear I bracket is fixedly installed on the bottom plate. The other end of the shaft of gear I is fixedly connected with bevel gear I, and bevel gear I and bevel gear II are meshed with each other. Bevel gear II is rotatably installed in the hole on the gear I bracket, and the lower end of the shaft of bevel gear II is fixedly connected with the inner shaft of the ratchet. The ratchet includes an inner shaft, ratchet teeth, and an outer wheel. When the inner shaft of the ratchet rotates counterclockwise, it can drive the ratchet teeth to drive the outer wheel to rotate. When the inner shaft of the ratchet rotates clockwise, the ratchet teeth rotate idly without driving the outer wheel to rotate. A tooth is provided on the outside of the outer wheel. One rotation of the outer wheel can drive gear II to rotate an angle. The lower end of gear II is rotatably installed on the board on the bottom plate, gear II is fixedly connected to the lower docking tube II, and a slot is provided on the inner side of the lower docking tube II. The slot is used to clamp the test tube storage part.

[0011] Preferably, the test tube storage part comprises: a turntable, an upper docking tube, a button, a docking block, and a connecting rod;

[0012] The turntable is provided with a plurality of holes, and an upper docking tube is provided in the middle position of the turntable. The interior of the upper docking tube is a hollow structure, and four holes are provided on the outer side of the lower end of the upper docking tube. A docking block is movably installed in each hole. The docking block is connected to the button through a spring, and the docking block is connected through a connecting rod. The upper end surface of the middle position of the connecting rod is fixedly connected to the lower end of the button, and the button is slidably installed inside the upper docking tube.

[0013] Preferably, the plug opening part comprises: a fixed bracket, a screw I, a motor II, a motor III, a screw II, a test tube clamping mechanism, and a side connecting rod;

[0014] The fixed bracket is fixedly installed on the bottom plate, and a lead screw I is rotatably installed on the fixed bracket, the upper end of the lead screw I is fixedly connected to the shaft of the motor II, and the motor II is fixedly installed on the upper end surface of the fixed bracket; the motor III is fixedly installed on the upper end surface of the fixed bracket, the shaft of the motor III is fixedly connected to the lead screw II, the lead screw II is threadedly connected to the upper test tube clamping mechanism, and the lead screw I is threadedly connected to the lower test tube clamping mechanism; the upper end of the side connecting rod is rotatably connected to the upper test tube clamping mechanism, and the lower end of the side connecting rod is rotatably connected to the lower test tube clamping mechanism.

[0015] Preferably, the test tube clamping mechanism comprises: a movable disk, a lower clamp, an upper clamp, a gear III, and a gear IV;

[0016] The movable disk is provided with a number of holes. A lower clamp is rotatably mounted on the movable disk. A sawtooth is provided at the middle position of the lower clamp. An upper clamp is rotatably mounted above the lower clamp. A sawtooth is provided at the middle position of the upper clamp. The lower end of Gear III is rotatably mounted on the fixed bracket. Gear III meshes with the internal sawtooth of the upper clamp. Gear III meshes with Gear IV. Gear IV meshes with the sawtooth of the lower clamp. Gear IV is fixedly connected to the shaft of the motor fixedly installed on the movable disk.

[0017] Preferably, the telescopic frame part includes: a folding frame and a fixed clamp; the rear end of the folding frame is fixedly installed on the bottom plate, and the front end of the folding frame is fixedly installed with a fixed clamp.

[0018] Preferably, the medicine-taking part includes: a motor IV, a lead screw III, a moving plate, a suction needle, and an output pipe;

[0019] The motor IV is fixedly installed on the bottom plate. The shaft of the motor IV is fixedly connected to the lead screw III. The lead screw III is threadedly connected to the moving plate. The moving plate is slidably connected to the limiting rod. The limiting rod of the moving plate is fixedly installed on the bottom plate. A number of suction needles are fixedly installed on the lower end surface of the moving plate. The number of suction needles is the same as the number of holes on the turntable. The upper tubes of the suction needles are connected to the pump inlets on the moving plate. The pump outlet is connected to one end of the output pipe. The other end of the output pipe outputs the liquid medicine in the test tube to a specific container.

[0020] The beneficial effects of the present invention compared with the prior art are as follows:

[0021] 1. Manually insert the test tube filled with liquid medicine into the clip on the test tube conveyor belt. Drive the test tube to rotate through the test tube conveyor belt. When the test tube moves to one end, place the test tube into the hole of the turntable through the test tube moving mechanism, and perform this operation in sequence. The operation is simple and labor-saving.

[0022] 2. When the sliding rod moves upward, the rack at its rear end moves upward to drive Gear I to rotate, thereby driving Bevel Gear I to rotate, and then driving Bevel Gear II to rotate. Bevel Gear II drives the ratchet to rotate one circle. Only one tooth of the ratchet drives Gear II to rotate by one tooth angle. Thus, the lower docking cylinder II drives the turntable to rotate by one angle. At this time, the hole on the turntable where the test tube is placed moves away, and the next hole moves to the position for placing the test tube. Perform the above movements in sequence until the holes on the turntable are filled with test tubes. Each time a test tube is placed, the turntable automatically aligns the next hole to the original position, saving the cost of automation equipment.

[0023] 3. During the period of placing test tubes, another test tube storage part inside the centrifuge can first perform centrifugation. After centrifugation, the operation of separating and extracting the liquid medicine is carried out. When the test tubes on one turntable are all placed and centrifugation is required, the liquid medicine in the test tubes on the other turntable has been extracted. The operator removes the test tubes and places the empty test tube storage part back on the lower docking cylinder II, making full use of the time for placing test tubes and improving work efficiency.

[0024] 4. After centrifugation, the fixed clamp is extended by the folding frame to clamp one side of the turntable. When the folding frame retracts, the turntable with test tubes is moved between the two test tube clamping mechanisms. Then, the test tube caps are opened by the cooperation of the two test tube clamping mechanisms, which is very simple and convenient, and can open the caps of multiple test tubes at one time.

[0025] 5. The turntable with test tubes and the caps removed is moved to the position directly below the moving plate. The motor IV drives the lead screw III to rotate, thereby driving the moving plate to move downward by a specified depth. Different depths can extract liquid medicine from different layers, enabling multiple suction needles to be inserted into the test tubes on multiple turntables respectively. The solution in the test tubes is pumped through the pump on the moving plate, and then the liquid medicine is discharged from the output pipe into different containers, completing the layered separation of the liquid medicine, realizing full-automatic separation of the liquid medicine, saving labor, saving time, and reducing costs. Description of the Drawings

[0026] Figure 1 It is a schematic diagram of the first-angle structure of the overall structure of the present invention.

[0027] Figure 2 It is a schematic diagram of the second-angle structure of the overall structure of the present invention.

[0028] Figure 3 It is a schematic diagram of the third-angle structure of the overall structure of the present invention.

[0029] Figure 4 It is a schematic diagram of the first-angle structure of the feeding part of the present invention.

[0030] Figure 5 It is a schematic diagram of the second-angle structure of the feeding part of the present invention.

[0031] Figure 6 It is a schematic diagram of the third-angle structure of the feeding part of the present invention.

[0032] Figure 7 For the present invention Figure 6 Partial enlarged structure schematic diagram.

[0033] Figure 8 It is a schematic diagram of the first-angle structure of the test tube storage part of the present invention.

[0034] Figure 9This is a schematic diagram of the structure of the test tube storage part from a second angle of the present invention.

[0035] Figure 10 It is a schematic structural diagram of the unplugging part of the present invention.

[0036] Figure 11 It is a structural schematic diagram of the test tube clamping mechanism of the plugging part of the present invention.

[0037] Figure 12 It is a schematic structural diagram of the telescopic frame part of the present invention.

[0038] Figure 13 It is a schematic diagram of the structure of the medicine taking part of the present invention.

[0039] Figure numbers: 1-feeding part; 2-test tube storage part; 3-opening part; 4-telescopic frame part; 5-medicine taking part; 101-bottom plate; 102-test tube conveyor belt; 103-centrifuge; 104-lower docking cylinder Ⅰ; 105-lateral moving track; 106-electric cylinder; 107-motor Ⅰ; 108-movable connecting rod; 109-rectangular plate; 110-sliding plate; 111-sliding rod; 112-rack; 113-gear Ⅰ; 114-gear Ⅰ bracket; 115-bevel gear Ⅰ; 116-bevel gear Ⅱ; 117-ratchet; 118-gear Ⅱ; 119-lower docking Cylinder II; 201-turntable; 202-upper docking cylinder; 203-button; 204-docking block; 205-connecting rod; 301-fixed bracket; 302-screw I; 303-motor II; 304-motor III; 305-screw II; 306-gripping test tube mechanism; 307-side connecting rod; 3061-movable disk; 3062-lower clamp; 3063-upper clamp; 3064-gear III; 3065-gear IV; 401-folding frame; 402-fixed clamp; 501-motor IV; 502-screw III; 503-movable plate; 504-absorption needle; 505-output tube. DETAILED DESCRIPTION

[0040] The technical solution of the present invention is further specifically described below by way of embodiments and in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0041] It should be noted that phrases such as "an embodiment", "embodiments", "exemplary embodiments", "some embodiments", etc. mentioned in the specification indicate that the described embodiments may include specific features, structures or characteristics, but not necessarily every embodiment includes such specific features, structures or characteristics. In addition, such phrases do not necessarily refer to the same embodiment. Moreover, when combining a specific feature, structure or characteristic with an embodiment, it is within the knowledge scope of those skilled in the art to implement such a feature, structure or characteristic in combination with other embodiments, whether explicitly or implicitly described.

[0042] In an alternative embodiment of the embodiment of the present invention, as Figures 1 - 13 shown, a centrifugal separation device for biopharmaceuticals includes: a feeding part 1, a test tube storage part 2, a tube opening part 3, a telescopic frame part 4, and a medicine taking part 5. It is characterized in that the feeding part 1 includes: a bottom plate 101, a test tube conveyor belt 102, a centrifuge 103, a lower docking cylinder I 104, and a moving test tube mechanism; the bottom plate 101 is fixedly installed with a test tube conveyor belt 102, and a number of test tube clamps are provided on the test tube conveyor belt 102. An artificial person places the test tube into the test tube clamp on the test tube conveyor belt 102. The centrifuge 103 is placed on the bottom plate 101, and the upper cover of the centrifuge 103 is a push-pull type cover. The motor shaft of the centrifugal motor inside the centrifuge 103 is fixedly connected to the lower docking cylinder I 104; there are two test tube storage parts 2, and the two test tube storage parts 2 are replaced. When one test tube storage part 2 stores test tubes, the other test tube storage part 2 is placed on the lower docking cylinder I 104 for centrifugal separation work; the tube opening part 3 is fixedly installed on the bottom plate 101, and the tube opening part 3 is used to open the test tube stopper on the test tube storage part 2 after centrifugal separation; the telescopic frame part 4 is fixedly installed on the bottom plate 101, and the telescopic frame part 4 is used to first move the test tube storage part 2 after centrifugal separation to the middle position of the tube opening part 3, and then move the test tube storage part 2 with the removed test tube stopper to the lower part of the medicine taking part 5; the medicine taking part 5 is fixedly installed on the bottom plate 101, and the medicine taking part 5 is located on the side of the tube opening part 3. The medicine taking part 5 is used to extract the liquid medicine at different heights in the separated test tube.

[0043] In an alternative embodiment of the embodiment of the present invention, as Figure 4 and 5As shown in the figure, the feeding part 1 further includes: a transverse moving track 105 and an electric cylinder 106; the transverse moving track 105 includes a bracket, a motor, a lead screw and a slider. The bracket is fixedly installed on the bottom plate 101, a motor is fixedly installed at the end of the bracket, the shaft of the motor is fixedly connected to the lead screw, the lead screw is threadedly connected to the slider, the slider is slidably installed on the bracket, the slider is fixedly connected to the cylinder body of the electric cylinder 106, and the end of the piston rod of the electric cylinder 106 is installed with a mechanical claw. A push rod is arranged at the middle position of the mechanical claw. By pushing the mechanical claw downward through the electric cylinder 106, the push rod inside the mechanical claw first presses on the button 203, the button 203 presses down the connecting rod 205 so that the docking block 204 retracts, and then the mechanical claw clamps the upper end of the upper docking cylinder 202. The electric cylinder 106 rises to pick up the turntable 201, and then the motor on the transverse moving track 105 drives the slider to move, thereby driving the electric cylinder 106 to move and further driving the mechanical claw to clamp the turntable 201 and move it above the centrifuge 103.

[0044] In an alternative embodiment of the embodiment of the present invention, as Figure 5 shown, the moving test tube mechanism of the feeding part 1 includes: a motor I 107, a movable connecting rod 108, a rectangular plate 109, a sliding plate 110, and a sliding rod 111; the motor I 107 is fixedly installed on the bracket on the bottom plate 101, the motor shaft of the motor I 107 is fixedly connected to one end of the movable connecting rod 108, the other end of the movable connecting rod 108 is rotatably connected to the sliding plate 110, the sliding plate 110 is slidably installed on the rectangular plate 109, a V-shaped groove is provided on the sliding plate 110, the rectangular plate 109 is fixedly installed on the bracket on the bottom plate 101, and a U-shaped groove is provided on the rectangular plate 109; the sliding rods 111 are respectively slidably installed in the chute of the rectangular plate 109 and the sliding plate 110, and a mechanical claw is fixedly installed at the lower end of the sliding rod 111; by pushing the movable connecting rod 108 to move through the motor I 107, the sliding plate 110 is pushed to move. Since the sliding rod 111 is simultaneously slidably installed in the grooves of the sliding plate 110 and the rectangular plate 109, and the slot hole on the sliding plate 110 is an inclined surface, the movement track of the sliding rod 111 is to first move upward from bottom to top along the groove on one side of the rectangular plate 109, then translate along the horizontal groove on the upper surface of the rectangular plate 109 to the vertical slot hole on the other side, and then move downward from top to bottom, completing the mechanical claw below the sliding rod 111 first picking up the test tube at the end of the test tube conveyor belt 102 and translating it above the corresponding hole on the turntable 201, and then moving downward while the mechanical claw opens to place the test tube into the hole of the turntable 201.

[0045] In an alternative embodiment of the embodiment of the present invention, as Figure 6 and Figure 7 shown, the feeding part 1 further includes: a rack 112, a gear I 113, a gear I bracket 114, a bevel gear I 115, a bevel gear II 116, a ratchet 117, a gear II 118, and a lower docking cylinder II 119;

[0046] The upper end of the rack 112 is fixedly mounted on the rear end of the slide bar 111, the rack 112 is intermittently meshed with the gear I 113, the gear I 113 is rotatably mounted on the gear I bracket 114, the gear I bracket 114 is fixedly mounted on the bottom plate 101, the other end of the shaft of the gear I 113 is fixedly connected with the bevel gear I 115, the bevel gear I 115 and the bevel gear II 116 are meshed with each other, the bevel gear II 116 is rotatably mounted in the hole on the gear I bracket 114, the lower end of the shaft of the bevel gear II 116 is fixedly connected with the inner shaft of the ratchet 117, the ratchet 117 includes an inner shaft, ratchet teeth, and an outer wheel, when the inner shaft of the ratchet 117 rotates counterclockwise, it can drive the ratchet teeth to drive the outer wheel to rotate, when the inner shaft of the ratchet 117 rotates clockwise, the ratchet teeth rotate idly without driving the outer wheel to rotate, and a tooth is provided on the outer side of the outer wheel, The outer wheel rotates one circle to drive gear II 118 to rotate one angle. The lower end of gear II 118 is rotatably mounted on a plate on the bottom plate 101. Gear II 118 is fixedly connected to the lower docking tube II 119. A slot is provided on the inner side of the lower docking tube II 119. The slot is used to clamp the test tube storage part 2. When the slide bar 111 moves upward, the rack 112 at its rear end moves upward to drive gear I 113 to rotate, thereby driving bevel gear I 115 to rotate and then driving bevel gear II 116 to rotate. Bevel gear II 116 drives the ratchet 117 to rotate one circle. The ratchet 117 has only one tooth that drives gear II 118 to rotate one tooth angle, so that the lower docking tube II 119 drives the turntable 201 to rotate one angle. At this time, the hole on the turntable 201 with the test tube is moved away, and the next hole moves to the position for placing the test tube.

[0047] In an optional implementation manner of the embodiment of the present invention, as Figure 8 and 9 As shown, the test tube storage part 2 includes: a turntable 201, an upper docking tube 202, a button 203, a docking block 204, and a connecting rod 205;

[0048] The turntable 201 is provided with a plurality of holes, and an upper docking tube 202 is provided in the middle position of the turntable 201. The interior of the upper docking tube 202 is a hollow structure, and four holes are provided on the outer side of the lower end of the upper docking tube 202. A docking block 204 is movably installed in each hole. The docking block 204 is connected to the button 203 through a spring, and the docking block 204 is connected through a connecting rod 205. The upper end surface of the middle position of the connecting rod 205 is fixedly connected to the lower end of the button 203. The button 203 is slidably installed inside the upper docking tube 202, and the button 203 presses down the connecting rod 205 so that the docking block 204 is retracted.

[0049] In an optional implementation manner of the embodiment of the present invention, Figure 10 As shown, the plug opening part 3 includes: a fixed bracket 301, a screw I 302, a motor II 303, a motor III 304, a screw II 305, a test tube clamping mechanism 306, and a side connecting rod 307;

[0050] The described fixed bracket 301 is fixedly installed on the bottom plate 101. A lead screw I 302 is rotatably installed on the fixed bracket 301. The upper end of the lead screw I 302 is fixedly connected to the shaft of the motor II 303, and the motor II 303 is fixedly installed on the upper end surface of the fixed bracket 301; the motor III 304 is fixedly installed on the upper end surface of the fixed bracket 301, the shaft of the motor III 304 is fixedly connected to the lead screw II 305, the lead screw II 305 is threadedly connected to the clamping test tube mechanism 306 above, and the lead screw I 302 is threadedly connected to the clamping test tube mechanism 306 below; the upper end of the side link 307 is rotatably connected to the clamping test tube mechanism 306 above, and the lower end of the side link 307 is rotatably connected to the clamping test tube mechanism 306 below. By driving the lead screw I 302 to rotate through the motor II 303, the clamping test tube mechanism 306 below is driven to move upward, so that the bottom of the test tube passes through the hole in the lower movable plate 3061. The test tube is clamped by the clamping test tube mechanism 306. By driving the lead screw II 305 to rotate through the motor III 304, the clamping test tube mechanism 306 above is driven to move downward to cover and clamp the test tube cap. Then, the clamping test tube mechanism 306 above clamps the test tube cap and moves upward. At this time, the clamping test tube mechanism 306 below clamps the test tube body. Therefore, the test tube cap can be opened.

[0051] In an alternative embodiment of the embodiment of the present invention, as Figure 11 shown, the clamping test tube mechanism 306 includes: a movable plate 3061, a lower clamp 3062, an upper clamp 3063, a gear III 3064, and a gear IV 3065;

[0052] The movable plate 3061 is provided with a plurality of holes. The lower clamp 3062 is rotatably installed on the movable plate 3061. A sawtooth is provided at the middle position of the lower clamp 3062. The upper clamp 3063 is rotatably installed above the lower clamp 3062. A sawtooth is provided at the middle position of the upper clamp 3063; the lower end of the gear III 3064 is rotatably installed on the fixed bracket 301. The gear III 3064 meshes with the internal sawtooth of the upper clamp 3063. The gear III 3064 meshes with the gear IV 3065. The gear IV 3065 meshes with the sawtooth of the lower clamp 3062. The gear IV 3065 is fixedly connected to the shaft of the motor fixedly installed on the movable plate 3061. By driving the gear IV 3065 to rotate through the motor on the movable plate 3061, the lower clamp 3062 is driven to rotate clockwise. At the same time, the gear IV 3065 drives the gear III 3064 to rotate, thereby driving the upper clamp 3063 to rotate counterclockwise. The outer ends of the lower clamp 3062 and the upper clamp 3063 clamp the test tube wall.

[0053] In an alternative embodiment of the embodiment of the present invention, as Figure 12As shown, the telescopic frame part 4 includes: a folding frame 401 and a fixed clamp 402; the rear end of the folding frame 401 is fixedly installed on the bottom plate 101, and the front end of the folding frame 401 is fixedly installed with a fixed clamp 402. The fixed clamp 402 is driven to move by the folding frame 401, and the turntable 201 is clamped by the fixed clamp 402.

[0054] In an alternative embodiment of the embodiment of the present invention, as Figure 13 shown, the medicine-taking part 5 includes: a motor IV 501, a lead screw III 502, a moving plate 503, a suction needle 504, and an output pipe 505;

[0055] The motor IV 501 is fixedly installed on the bottom plate 101. The shaft of the motor IV 501 is fixedly connected to the lead screw III 502. The lead screw III 502 is threadedly connected to the moving plate 503. The moving plate 503 is slidably connected to the limit rod. The limit rod of the moving plate 503 is fixedly installed on the bottom plate 101. A plurality of suction needles 504 are fixedly installed on the lower end surface of the moving plate 503. The number of suction needles 504 is the same as the number of holes on the turntable 201. The upper end tubes of the suction needles 504 are connected to the pump inlets on the moving plate 503. The pump outlet is connected to one end of the output pipe 505. The other end of the output pipe 505 outputs the liquid medicine in the test tube to a specific container. By driving the lead screw III 502 to rotate by the motor IV 501, the moving plate 503 is driven to move downward to a specified depth. Different depths can extract different stratified liquid medicines. The plurality of suction needles 504 are respectively inserted into the test tubes on the plurality of turntables 201. The solution in the test tube is extracted by the pump on the moving plate 503, and then the liquid medicine is discharged from the output pipe 505 into different containers, completing the stratified separation of the liquid medicine and realizing the full-automatic separation of the liquid medicine.

[0056] Working principle:

[0057] When the present invention is in use, first, a test tube filled with liquid medicine is manually inserted into a clip on the test tube conveyor belt 102. The test tube conveyor belt 102 drives the test tube to rotate. When the test tube moves to one end, the motor I 107 drives the movable connecting rod 108 to rotate, thereby driving the sliding plate 110 to move, and further driving the sliding rod 111 to move to the end of the test tube conveyor belt 102. The test tube at the end of the test tube conveyor belt 102 is clamped by the mechanical claw at the lower end of the sliding rod 111. Since the rectangular plate 109 is provided with a U-shaped groove and the sliding plate 110 is provided with a V-shaped groove, the motor I 107 pushes the movable connecting rod 108 to move, thereby pushing the sliding plate 110 to move. Since the sliding rod 111 is slidably installed in the grooves of both the sliding plate 110 and the rectangular plate 109, and the slot hole on the sliding plate 110 is an inclined plane, the movement track of the sliding rod 111 is to first move upward along the groove on one side of the rectangular plate 109 from bottom to top, then translate along the horizontal groove on the upper surface of the rectangular plate 109 to the vertical slot hole on the other side, and then move downward from top to bottom. The mechanical claw below the sliding rod 111 first picks up the test tube at the end of the test tube conveyor belt 102 and translates it above the corresponding hole on the turntable 201, and then moves downward while the mechanical claw opens to place the test tube into the hole of the turntable 201. Next, the sliding rod 111 needs to move upward and return to its original position to pick up the next test tube. When the sliding rod 111 moves upward, the rack 112 at its rear end moves upward, driving the gear I 113 to rotate, thereby driving the bevel gear I 115 to rotate, and further driving the bevel gear II 116 to rotate. The bevel gear II 116 drives the ratchet 117 to rotate one circle. The ratchet 117 has only one tooth, driving the gear II 118 to rotate by an angle of one tooth. Thus, the lower docking cylinder II 119 drives the turntable 201 to rotate by an angle. At this time, the hole on the turntable 201 where the test tube is placed moves away, and the next hole moves to the position for placing the test tube. The above movements are performed in sequence until the holes on the turntable 201 are filled with test tubes. During the placement of the test tubes, another test tube storage part 2 inside the centrifugal separator 103 can first perform centrifugal separation, and after the centrifugation is completed, the operation of separating and extracting the liquid medicine is carried out. When the test tubes on one turntable 201 are filled and centrifugal separation needs to be performed, the liquid medicine in the test tubes on the other turntable 201 has been extracted. The test tubes are manually removed, and the empty test tube storage part 2 is placed back on the lower docking cylinder II 119 again, making full use of the time for placing the test tubes and improving the work efficiency.

[0058] Next, the electric cylinder 106 is used to push the mechanical claw downward. The ejector rod inside the mechanical claw first presses on the button 203, and the button 203 presses down the connecting rod 205, causing the docking block 204 to retract. Then the mechanical claw clamps the upper end of the upper docking cylinder 202, and the electric cylinder 106 rises to pick up the turntable 201. Next, the motor on the horizontal moving track 105 drives the slider to move, which drives the electric cylinder 106 to move, and then drives the mechanical claw to clamp the turntable 201 and move it above the centrifuge 103. Then the electric cylinder 106 moves downward to insert the docking block 204 into the lower docking cylinder I 104 to complete the fastening. Then the centrifuge 103 covers the lid and drives the turntable 201 with test tubes inside to rotate for centrifugal separation. After the centrifuge 103 finishes separating the turntable 201, the electric cylinder 106 is used to push the mechanical claw downward. The ejector rod inside the mechanical claw first presses on the button 203, and the button 203 presses down the connecting rod 205, causing the docking block 204 to retract. Then the mechanical claw clamps the upper end of the upper docking cylinder 202, and the electric cylinder 106 rises to pick up the turntable 201 above the centrifuge 103. Then the folding frame 401 extends and the fixed clamp 402 clamps one side of the turntable 201. The folding frame 401 retracts to move the turntable 201 with test tubes to between the two test tube clamping mechanisms 306. Then the motor II 303 drives the lead screw I 302 to rotate, driving the lower test tube clamping mechanism 306 to move upward, so that the bottom of the test tube passes through the hole in the lower movable plate 3061. The motor on the movable plate 3061 drives the gear IV 3065 to rotate, driving the lower clamp 3062 to rotate clockwise. At the same time, the gear IV 3065 drives the gear III 3064 to rotate, driving the upper clamp 3063 to rotate counterclockwise. The outer ends of the lower clamp 3062 and the upper clamp 3063 clamp the test tube wall. At the same time, the motor III 304 drives the lead screw II 305 to rotate, driving the upper test tube clamping mechanism 306 to move downward to cover and clamp the test tube cap. Then the upper test tube clamping mechanism 306 clamps the test tube cap and moves upward. At this time, the lower test tube clamping mechanism 306 clamps the test tube body, so the test tube cap can be opened. Next, the folding frame 401 drives the fixed clamp 402 to move, driving the turntable 201 with test tubes and without a cap to move to directly below the moving plate 503. The motor IV 501 drives the lead screw III 502 to rotate, driving the moving plate 503 to move downward to a specified depth. Different depths can extract different stratified liquid medicines. The multiple suction needles 504 are respectively inserted into the test tubes on the multiple turntables 201. The pump on the moving plate 503 extracts the solution in the test tubes, and then discharges the liquid medicine from the output pipe 505 into different containers, completing the stratified separation of the liquid medicine, realizing the full-automatic separation of the liquid medicine, saving labor, saving time, and reducing costs.

Claims

1. A centrifugal separation device for biopharmaceuticals, comprising: The feeding part (1), the test tube storage part (2), the tube opening part (3), the telescopic rack part (4), and the medicine taking part (5), characterized in that the feeding part (1) includes: a bottom plate (101), a test tube conveyor belt (102), a centrifuge (103), a lower docking cylinder I (104), and a moving test tube mechanism; the bottom plate (101) is fixedly installed with a test tube conveyor belt (102), and a number of test tube clamps are provided on the test tube conveyor belt (102). An operator places the test tubes into the test tube clamps on the test tube conveyor belt (102). The centrifuge (103) is placed on the bottom plate (101), and the upper cover of the centrifuge (103) is a push-pull type cover. The motor shaft of the centrifugal motor inside the centrifuge (103) is fixedly connected to the lower docking cylinder I (104); there are two test tube storage parts (2), and the two test tube storage parts (2) are replaced. When one test tube storage part (2) stores test tubes, the other test tube storage part (2) is placed on the lower docking cylinder I (104) for centrifugation work; the tube opening part (3) is fixedly installed on the bottom plate (101), and the tube opening part (3) is used to open the test tube stopper on the test tube storage part (2) after centrifugation; the telescopic rack part (4) is fixedly installed on the bottom plate (101), and the telescopic rack part (4) is used to first move the test tube storage part (2) after centrifugation to the middle position of the tube opening part (3), and then move the test tube storage part (2) with the removed test tube stopper to the lower part of the medicine taking part (5); the medicine taking part (5) is fixedly installed on the bottom plate (101), the medicine taking part (5) is located on the side of the tube opening part (3), and the medicine taking part (5) is used to extract the liquid medicine at different heights in the separated test tubes. The tube opening part (3) includes: a fixed bracket (301), a lead screw I (302), a motor II (303), a motor III (304), a lead screw II (305), a test tube clamping mechanism (306), and a side connecting rod (307); the fixed bracket (301) is fixedly installed on the bottom plate (101), and the lead screw I (302) is rotatably installed on the fixed bracket (301). The upper end of the lead screw I (302) is fixedly connected to the shaft of the motor II (303), and the motor II (303) is fixedly installed on the upper end surface of the fixed bracket (301); the motor III (304) is fixedly installed on the upper end surface of the fixed bracket (301), the shaft of the motor III (304) is fixedly connected to the lead screw II (305), the lead screw II (305) is threadedly connected to the upper test tube clamping mechanism (306), and the lead screw I (302) is threadedly connected to the lower test tube clamping mechanism (306); the upper end of the side connecting rod (307) is rotatably connected to the upper test tube clamping mechanism (306), and the lower end of the side connecting rod (307) is rotatably connected to the lower test tube clamping mechanism (306). The described test tube clamping mechanism (306) includes: a movable disk (3061), a lower clamp (3062), an upper clamp (3063), a gear III (3064), and a gear IV (3065); several holes are provided on the movable disk (3061), the lower clamp (3062) is rotatably installed on the movable disk (3061), sawteeth are provided at the middle position of the lower clamp (3062), the upper clamp (3063) is rotatably installed above the lower clamp (3062), and sawteeth are provided at the middle position of the upper clamp (3063); the lower end of the gear III (3064) is rotatably installed on the fixed bracket (301), the gear III (3064) meshes with the internal sawteeth of the upper clamp (3063), the gear III (3064) meshes with the gear IV (3065), the gear IV (3065) meshes with the sawteeth of the lower clamp (3062), and the gear IV (3065) is fixedly connected to the shaft of the motor fixedly installed on the movable disk (3061).

2. The centrifugal separation device for biopharmaceuticals according to claim 1, characterized in that: The described feeding part (1) further includes: a lateral moving track (105) and an electric cylinder (106); the lateral moving track (105) includes a bracket, a motor, a lead screw, and a slider. The bracket is fixedly installed on the bottom plate (101), a motor is fixedly installed at the end of the bracket, the shaft of the motor is fixedly connected to the lead screw, the lead screw is threadedly connected to the slider, the slider is slidably installed on the bracket, the slider is fixedly connected to the cylinder body of the electric cylinder (106), and a mechanical claw is installed at the end of the piston rod of the electric cylinder (106), and a push rod is provided at the middle position of the mechanical claw.

3. The centrifugal separation device for biopharmaceuticals according to claim 1, characterized in that: The moving test tube mechanism of the described feeding part (1) includes: a motor I (107), a movable connecting rod (108), a rectangular plate (109), a sliding plate (110), and a sliding rod (111); the motor I (107) is fixedly installed on the bracket on the bottom plate (101), the motor shaft of the motor I (107) is fixedly connected to one end of the movable connecting rod (108), the other end of the movable connecting rod (108) is rotatably connected to the sliding plate (110), the sliding plate (110) is slidably installed on the rectangular plate (109), a V-shaped groove is provided on the sliding plate (110), the rectangular plate (109) is fixedly installed on the bracket on the bottom plate (101), and a U-shaped groove is provided on the rectangular plate (109); the sliding rod (111) is slidably installed in the chutes of the rectangular plate (109) and the sliding plate (110) respectively, and a mechanical claw is fixedly installed at the lower end of the sliding rod (111).

4. A centrifugal separation device for biopharmaceuticals according to any one of claims 1-3, characterized in that: The feeding part (1) further comprises: a rack (112), a gear I (113), a gear I bracket (114), a bevel gear I (115), a bevel gear II (116), a ratchet (117), a gear II (118), and a lower docking tube II (119); the upper end of the rack (112) is fixedly mounted on the rear end of the slide bar (111), the rack (112) and the gear I (113) are intermittently meshed, the gear I (113) is rotatably mounted on the gear I bracket (114), the gear I bracket (114) is fixedly mounted on the bottom plate (101), the other end of the shaft of the gear I (113) is fixedly connected to the bevel gear I (115), the bevel gear I (115) and the bevel gear II (116) are meshed with each other, the bevel gear II (11 6) is rotatably mounted in a hole on the gear I bracket (114), the lower end of the shaft of the bevel gear II (116) is fixedly connected to the inner shaft of the ratchet (117), the ratchet (117) comprises an inner shaft, ratchet teeth and an outer wheel, when the inner shaft of the ratchet (117) rotates counterclockwise, the ratchet teeth can drive the outer wheel to rotate, when the inner shaft of the ratchet (117) rotates clockwise, the ratchet teeth rotate idly without driving the outer wheel to rotate, a tooth is provided on the outer side of the outer wheel, and one rotation of the outer wheel can drive the gear II (118) to rotate an angle, the lower end of the gear II (118) is rotatably mounted on a plate on the bottom plate (101), the gear II (118) is fixedly connected to the lower docking sleeve II (119), and a slot is provided on the inner side of the lower docking sleeve II (119), and the slot is used to clamp the test tube storage part (2).

5. The centrifugal separation device for biopharmaceuticals according to claim 1, characterized in that: The test tube storage part (2) comprises: a turntable (201), an upper docking tube (202), a button (203), a docking block (204), and a connecting rod (205); the turntable (201) is provided with a plurality of holes, an upper docking tube (202) is provided in the middle of the turntable (201), the interior of the upper docking tube (202) is a hollow structure, four holes are provided on the outer side of the lower end of the upper docking tube (202), a docking block (204) is movably installed in each hole, the docking block (204) is connected to the button (203) by a spring, the docking block (204) is connected by a connecting rod (205), the upper end surface of the middle position of the connecting rod (205) is fixedly connected to the lower end of the button (203), and the button (203) is slidably installed in the upper docking tube (202).

6. A centrifugal separation device for biopharmaceuticals according to claim 1, characterized in that: The telescopic frame part (4) comprises: a folding frame (401) and a fixing clamp (402); the rear end of the folding frame (401) is fixedly mounted on the bottom plate (101), and the front end of the folding frame (401) is fixedly mounted with the fixing clamp (402).

7. The centrifugal separation device for biopharmaceuticals according to claim 1, wherein: The medicine-taking part (5) includes: motor IV (501), lead screw III (502), moving plate (503), suction needle (504), output pipe (505); the motor IV (501) is fixedly installed on the bottom plate (101), the shaft of the motor IV (501) is fixedly connected to the lead screw III (502), the lead screw III (502) is threadedly connected to the moving plate (503), the moving plate (503) is slidably connected to the limit rod, the limit rod of the moving plate (503) is fixedly installed on the bottom plate (101), several suction needles (504) are fixedly installed on the lower end surface of the moving plate (503), the number of the suction needles (504) is the same as the number of holes on the turntable (201), the upper end tubes of the suction needles (504) are connected to the pump inlets on the moving plate (503), the pump outlet is connected to one end of the output pipe (505), and the other end of the output pipe (505) outputs the liquid medicine in the test tube into the container.

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