Solvent storage device and pipetting system
By designing a solvent storage device that includes container support and sealing components, efficient storage and convenient liquid transfer of containers within the same space are achieved, solving the problems of large container space occupation and long operation time.
Patent Information
- Application Number
- CN202210665998.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-06-14
- Publication Date
- 2025-11-07
- Estimated Expiration
- 2042-06-14
AI Technical Summary
In automated biochemical sample preparation and analysis, as the number of solvent types increases, the containers occupy more space and the pipetting operation time becomes longer.
Design a solvent storage device comprising at least one frame, with a container support assembly and a sealing assembly inside the frame. A motion mechanism enables the linear movement of the container and the coordination of the sealing mechanism, reducing the need for individual operations.
It reduces the space occupied by multiple containers, simplifies pipetting operations, and improves the convenience and efficiency of pipetting.
Smart Images

Figure CN117262439B_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of automatic equipment, in particular to a solvent storage device and a pipetting system. BACKGROUND
[0002] In the process of automatic biochemical sample preparation and analysis, a pipetting pump is often used to pipette from a container. The process of pipetting involves operations such as taking a bottle, opening a cap, pipetting, closing a cap, and placing a bottle. With the increase in the number of solvent types, more containers are used, resulting in a large occupied space of the containers, and operating multiple containers one by one leads to a longer pipetting time. SUMMARY
[0003] To solve or partially solve the problems in the related art, the present application provides a solvent storage device and a pipetting system, which can reduce the occupied space of multiple containers and make pipetting operation more convenient.
[0004] The first aspect of the present application provides a solvent storage device, which is provided with at least one shelf body. The shelf body includes a containing cavity with an opening. A container carrying assembly for carrying a container is arranged in the containing cavity. The container carrying assembly is provided with a plurality of container placing portions.
[0005] The container carrying assembly is connected to the shelf body through a first movement mechanism. The first movement mechanism is used to drive the container carrying assembly to move linearly at the opening.
[0006] In an embodiment, a container sealing assembly is arranged in the containing cavity. The container sealing assembly is connected to the shelf body through a second movement mechanism.
[0007] The container sealing assembly includes a sealing mechanism corresponding to the container placing portion. The second movement mechanism is used to drive the sealing mechanism to approach or move away from the container placing portion, so as to make the sealing mechanism sealingly cooperate with or be separated from the container port of the container.
[0008] In an embodiment, the first movement mechanism includes a first guide assembly and a first driving assembly. The container carrying assembly is slidably connected to the first guide assembly. The first driving assembly is drivingly connected to the container carrying assembly and is used to drive the container carrying assembly to move; and / or
[0009] The second movement mechanism includes a second guide assembly and a second driving assembly. The container sealing assembly is slidably connected to the second guide assembly. The second driving assembly is drivingly connected to the container sealing assembly and is used to drive the container sealing assembly to move.
[0010] In one embodiment, the container carrying assembly comprises a transverse moving plate and a container limiting plate arranged above the transverse moving plate; the transverse moving plate is slidably connected to the first guide assembly, and the first driving assembly is in transmission connection with the transverse moving plate.
[0011] The container placing part comprises a limiting hole arranged on the container limiting plate, and the container is placed in the limiting hole and supported on the transverse moving plate.
[0012] In one embodiment, the container sealing assembly comprises a longitudinal moving plate and a mounting plate arranged on the longitudinal moving plate; the longitudinal moving plate is slidably connected to the second guide assembly, and the second driving assembly is in transmission connection with the longitudinal moving plate, and the sealing mechanism is arranged on the mounting plate.
[0013] In one embodiment, the sealing mechanism comprises a guide column arranged on the mounting plate, and a sealing part is arranged on the guide column, and the sealing part corresponds to the container placing part and is used to be in contact with the container mouth of the container.
[0014] In one embodiment, the sealing part is movably arranged along the axial direction of the guide column, an elastic member is sleeved on the guide column, and two ends of the elastic member are respectively in abutment with the mounting plate and the sealing part.
[0015] In one embodiment, the sealing part comprises a supporting sheet sleeved on the guide column and a sealing sheet closely arranged on the supporting sheet, and two ends of the elastic member are respectively in abutment between the mounting plate and the supporting sheet.
[0016] The sealing sheet is below the supporting sheet, and the lower surface of the sealing sheet is used to be in contact with the container mouth of the container.
[0017] In one embodiment, a mounting hole is arranged on the mounting plate, and the guide column is arranged in the mounting hole; the upper end of the guide column is connected with a first fastener, the first fastener is in abutment with the upper side of the mounting plate; the lower end of the guide column is connected with a second fastener, and the sealing part is clamped between the second fastener and the elastic member; and the second fastener is in abutment with the side of the sealing part away from the elastic member.
[0018] In one embodiment, the first driving assembly comprises a first motor and a first driving rod in transmission cooperation with the first motor; the first motor is fixed to the frame body, the first driving rod is arranged along the transverse direction and is connected with the transverse moving plate to drive the transverse moving plate to move; and / or
[0019] The second driving assembly comprises a second motor and a second driving rod in driving cooperation with the second motor, the second motor is fixed to the frame body, and the second driving rod is arranged along the longitudinal direction and connected with the longitudinal moving plate to drive the longitudinal moving plate to move.
[0020] In one embodiment, the container sealing assembly is provided with a plurality of sealing mechanisms corresponding to a plurality of container placing portions.
[0021] In one embodiment, the container limiting plate and the transverse moving plate are arranged in a vertical direction.
[0022] When the container is placed in the limiting hole, the bottom of the container is supported on the upper surface of the transverse moving plate, and the outer side wall of the container abuts against the hole wall of the limiting hole.
[0023] In one embodiment, the frame body comprises a bottom plate, a top plate, a side plate and a back plate connected between the bottom plate and the top plate, the bottom plate, the top plate, the side plate and the back plate define the accommodating cavity, and the opening is arranged on the side opposite to the back plate.
[0024] In one embodiment, the frame body is provided with a plurality of layers, the plurality of layers of the frame body are fixedly combined or detachably combined into one, and the openings of the accommodating cavities of the plurality of layers of the frame body are arranged on the same side of the frame body.
[0025] The second aspect of the application provides a solvent storage device, comprising a pipetting device and the solvent storage device as described in the first aspect above, the pipetting device is used for pipetting from the container stored in the solvent storage device.
[0026] The technical solution provided in the application can have the following beneficial effects:
[0027] The solvent storage device provided in the embodiment of the application is provided with at least one layer of frame body, the frame body comprises an accommodating cavity with an opening, the accommodating cavity is provided with a container carrying assembly for carrying a container, and the container carrying assembly is provided with a plurality of container placing portions; wherein the container carrying assembly is connected with the frame body through a first moving mechanism, and the first moving mechanism is used for driving the container carrying assembly to move linearly at the opening. The solvent storage device provided in the embodiment of the application can drive the container carrying assembly to move linearly at the opening of the accommodating cavity, for example, to move out of the accommodating cavity or into the accommodating cavity through the opening, so that the pipetting operation is more convenient, a plurality of containers in each layer of frame body can be stably placed in the container carrying device, more containers can be accommodated in the same space, and the space occupation of the plurality of containers is reduced.
[0028] Further, the accommodating cavity is provided with a container sealing assembly connected with the frame body through a second moving mechanism; the container sealing assembly comprises a sealing mechanism corresponding to the container placing part, and the second moving mechanism is used to drive the sealing mechanism to approach or move away from the container placing part, so as to make the sealing mechanism seal with or separate from the container port, and the opening and sealing operations of the multiple containers are not needed one by one, and the operation time of the pipetting process is reduced.
[0029] It should be understood that the foregoing general description and the following detailed description are only exemplary and explanatory and are not restrictive of the application. BRIEF DESCRIPTION OF DRAWINGS
[0030] The above and other objects, features and advantages of the present application will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings in which like reference characters refer to like parts throughout and in which:
[0031] Figure 1 is a front view of a solvent storage device according to an embodiment of the present application;
[0032] Figure 2 is Figure 1 is a top view of the solvent storage device shown;
[0033] Figure 3 is Figure 1 is a perspective view of the solvent storage device shown;
[0034] Figure 4 is a front view of a container sealing assembly of the solvent storage device according to an embodiment of the present application;
[0035] Figure 5 is Figure 4 is a top view of the container sealing assembly of the solvent storage device shown;
[0036] Figure 6 is Figure 5 is a sectional view along A-A in FIG. 8;
[0037] Figure 7 is Figure 6 is an enlarged view of B in FIG. 8;
[0038] Figure 8 is a perspective view of a multi-layer frame body of the solvent storage device according to an embodiment of the present application;
[0039] Figure 9 is Figure 8 is a front view of the multi-layer frame body of the solvent storage device shown.
[0040] LIST OF REFERENCE NUMERALS:
[0041] 100, frame; 110, bottom plate, 120, side plate; 130, back plate; 150, accommodating cavity; 111, first photoelectric switch; 131, second photoelectric switch; 200, container carrying assembly; 210, transverse moving plate; 220, container limiting plate; 221, container placing part; 222, container; 2221, container opening; 300, first moving mechanism; 310, transverse guide rail; 320, first motor; 330, first driving rod; 400, second moving mechanism; 410, longitudinal guide rail; 420, second motor; 430, second driving rod; 500, container sealing assembly; 510, longitudinal moving plate; 520, mounting plate; 530, sealing mechanism; 531, guide column; 532, supporting sheet; 533, sealing sheet; 534, first fastener; 535, second fastener; 536, spring; 537, first gasket; 538, second gasket. DETAILED DESCRIPTION
[0042] Embodiments of the present application will be described in more detail by referring to the drawings. Although embodiments of the present application are shown in the drawings, it is understood that the present application can be implemented in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided so that the present application will be thorough and complete, and will fully convey the scope of the present application to those skilled in the art.
[0043] It should be understood that although the terms "first", "second", "third", etc. can be used in this application to describe various information, these information should not be limited by these terms. These terms are only used to distinguish the same type of information from each other. For example, the first information can also be referred to as the second information, and similarly, the second information can also be referred to as the first information without departing from the scope of the present application. Therefore, the features defined as "first", "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise specifically limited.
[0044] In the description of the present application, it should be understood that the terms "length", "width", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only used to facilitate the description of the present application and simplify the description, and therefore cannot be understood as indicating or implying that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.
[0045] Unless otherwise defined, the terms "mounting", "connected", "connecting", "fixed", and "fixedly" are not to be construed as being terminated with a specific manner, for example, can be fixedly connected, can be detachably connected or integrated; can be mechanically connected, can be electrically connected; can be directly connected, can be indirectly connected through an intermediate medium, can be internal communication of two elements or interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in this application can be understood according to the specific circumstances.
[0046] In the process of automatic biochemical sample preparation and analysis, it is often necessary to use a pipetting pump to pipette from a container. The process of pipetting involves operations such as taking a bottle, opening a cap, pipetting, closing a cap, and placing a bottle. With the increase in the number of solvent types, more containers need to be used, resulting in a large occupied space, and operating multiple containers one by one can result in longer pipetting time. To solve the above problems, the solvent storage device provided by the embodiments of the present application can reduce the occupied space of multiple containers and make pipetting operation more convenient.
[0047] The technical solutions of the embodiments of the present application are described in detail below with reference to the drawings.
[0048] Figure 1 is the front view of the solvent storage device provided by the embodiments of the present application; Figure 2 is Figure 1 is the top view of the solvent storage device.
[0049] Referring to Figure 1 and Figure 2 The solvent storage device provided by the embodiments of the present application is provided with at least one shelf body 100, the shelf body 100 includes a containing cavity with an opening, a container carrying assembly 200 for carrying containers 222 is arranged in the containing cavity, and the container carrying assembly 200 is provided with a plurality of container placing parts 221; wherein the container carrying assembly 200 is connected with the shelf body 100 through a first movement mechanism 300, and the first movement mechanism 300 is used to drive the container carrying assembly 200 to move linearly at the opening.
[0050] The solvent storage device provided by the embodiments of the present application can stably place a plurality of containers 222 in the container carrying assembly 200 in each shelf body 100, can store a plurality of containers 222, can store more containers 222 in the same space, and the first movement mechanism 300 can drive the container carrying assembly 200 to move linearly at the opening, for example, can drive the container carrying assembly 200 to move linearly out of or into the containing cavity at the opening, that is, to enter or exit at the opening, so that the pipetting operation is more convenient.
[0051] The container 222 of the embodiment can be in the shape of a bottle, and the interior of the container 222 contains a solvent used for biochemical experiments. The plurality of containers 222 can contain different kinds of solvents. The upper portion of the container 222 has a container port 2221, and a pipetting component such as a pipetting pump or a pipetting gun can be inserted into the container 222 from the container port 2221 to perform pipetting.
[0052] Since the container carrying assembly 200 is provided with a plurality of container placement portions 221, the plurality of containers 222 can be respectively positioned in the plurality of container placement portions 221 of the container carrying assembly 200, and the plurality of containers 222 can remain stable when the container carrying assembly 200 moves.
[0053] Figure 8 FIG. 1 is a perspective view of a multilayer rack body of a solvent storage device according to an embodiment of the present application; Figure 9 FIG. 2 is a front view of the multilayer rack body of the solvent storage device shown in FIG. 1. Figure 8 FIG. 3 is a side view of the multilayer rack body of the solvent storage device shown in FIG. 1.
[0054] Referring to FIGS. 1 to 3, Figure 8 and Figure 9 In some embodiments, the rack body 100 is provided with multiple layers, and the multiple layers of the rack body 100 are arranged in the longitudinal direction Z and fixedly combined or detachably combined into one body, for example, Figure 8 The embodiment is provided with three rack bodies, namely, a rack body 100a, a rack body 100b, and a rack body 100c, which are arranged in the longitudinal direction Z. The rack body 100a is provided with a container carrying assembly 200a and a container sealing assembly 500a, the rack body 100b is provided with a container carrying assembly 200b and a container sealing assembly 500b, and the rack body 100c is provided with a container carrying assembly 200c and a container sealing assembly 500c.
[0055] The openings of the accommodating cavities of the rack body 100a, the rack body 100b, and the rack body 100c are arranged on the same side, which facilitates pipetting operation on the same side. The number of layers of the rack body can be selected according to actual needs to accommodate different numbers of containers 222.
[0056] In some embodiments, when the rack body has multiple layers, the multiple layers of the rack body are connected in sequence in the vertical direction. The bottom plate of an upper rack body (for example, the rack body 100b) is supported on the top of a lower rack body (for example, the rack body 100a), and a top plate can be arranged on the top of the uppermost rack body (for example, the rack body 100c). The top plate is provided with a plurality of positioning members, which are used in limiting cooperation with a support of another container placed on the top plate. The other container can be, for example, a test tube used for containing a reagent.
[0057] Referring to FIGS. 1 to 3, Figure 3 , Figure 4 and Figure 8In the embodiment, the rack body 100 is assembled by a plurality of plate bodies. For example, the rack body 100 can include a bottom plate 110, a top plate (not shown), a back plate 130 and two side plates 120 connected between the bottom plate 110 and the top plate. The bottom plate 110, the top plate, the back plate 130 and the two side plates 120 define a containing cavity. An opening of the containing cavity is arranged on the opposite side of the back plate 130. For example, the opening can be arranged in the transverse direction X. The container carrying assembly 200 can move from the opening to the inside or outside of the containing cavity. When the container carrying assembly 200 moves to the inside of the containing cavity, a plurality of containers 222 can be stored in the containing cavity. When the container carrying assembly 200 moves to the outside of the containing cavity, the plurality of containers 222 can be easily subjected to pipetting operation. In the embodiment, the container carrying assembly 200 is connected to the rack body 100 through a first movement mechanism 300. The first movement mechanism 300 can drive the container carrying assembly 200 to move. Continue to refer to Figure 2 and Figure 3 In an implementation, the first movement mechanism 300 includes a first guide assembly and a first driving assembly. The container carrying assembly 200 is slidably connected to the first guide assembly. The first driving assembly is in transmission connection with the container carrying assembly 200, and is configured to drive the container carrying assembly 200 to move, so that the plurality of containers 222 on the container carrying assembly 200 can move to the outside of the containing cavity or to the inside of the containing cavity.
[0058] In some embodiments, the first guide assembly includes two transverse guide rails 310 arranged in parallel on the bottom plate 110 of the rack body 100. The two transverse guide rails 310 include inner ends and outer ends. The inner ends are arranged close to the back plate 130 of the rack body 100. The outer ends extend to the opening of the containing cavity. The two transverse guide rails 310 are arranged in the containing cavity in the transverse direction X, and are arranged close to the two side plates 120 respectively. The container carrying assembly 200 is slidably connected to and supported on the two transverse guide rails 310.
[0059] Continue to refer to Figure 3 In some embodiments, the first driving assembly includes a first motor 320 and a first driving rod 330 in transmission cooperation with the first motor 320. The motor can be a linear stepper motor. The linear stepper motor can drive the first driving rod 330 to move linearly along the axial direction (i.e., the X-axis direction) of the first driving rod 330. The first motor 320 is fixedly arranged relative to the rack body 100. For example, the first motor 320 can be fixed to the rack body 100 through a fixing member (such as a motor fixing seat).
[0060] The first driving rod 330 is connected with the container carrying assembly 200, and specifically, the first driving rod 330 is connected with the lower side of the container carrying assembly 200, and can drive the container carrying assembly 200 to move along the transverse direction X. Since the plurality of containers 222 and the container carrying assembly 200 are limited in position and the positions can be kept relatively stable, the plurality of containers 222 can move simultaneously with the first driving rod 330. When the first driving rod 330 drives the container carrying assembly 200 to move towards the direction away from the opening, the plurality of containers 222 and the container carrying assembly 200 move out of the accommodating cavity. When the first driving rod 330 drives the container carrying assembly 200 to move towards the direction of the opening, the plurality of containers 222 and the container carrying assembly 200 move into the accommodating cavity.
[0061] In some embodiments, in order to ensure that the container carrying assembly 200 can be connected to slide with the first guide assembly, the frame body 100 is further provided with a first limiting assembly. The first limiting assembly is used for limiting the movement of the container carrying assembly 200, so that the container carrying assembly 200 is limited to a predetermined position inside or outside the accommodating cavity.
[0062] In an implementation manner, the first limiting assembly can include a first photoelectric switch 111 and a limiting screw. The first photoelectric switch 111 is arranged close to the inner end of the transverse guide rail 310. The photoelectric switch can sense the position of the transverse moving plate 210 moving into the accommodating cavity, so that the transverse moving plate 210 stops after moving to a specific position inside the accommodating cavity. The limiting screw is arranged close to the outer end of the transverse guide rail 310. When the container carrying assembly 200 moves out of the accommodating cavity, the limiting screw can block the container carrying assembly 200, so that the container carrying assembly 200 stops at a set position outside the accommodating cavity.
[0063] In some embodiments, the container carrying assembly 200 includes a transverse moving plate 210 and a container limiting plate 220 arranged above the transverse moving plate 210. The transverse moving plate 210 is connected with the first guide assembly and is slidably connected with the first guide assembly. For example, a sliding block can be mounted on the transverse guide rail 310, and the transverse moving plate 210 is fixed on the sliding block and can slide along the two transverse guide rails 310 with the sliding block. Figure 3 The container limiting plate 220 and the transverse moving plate 210 are arranged in the vertical direction and are spaced apart, that is, the container limiting plate 220 and the transverse moving plate 210 have a set distance in the longitudinal direction Z, are parallel to each other and are fixedly connected through a plurality of vertical columns. The container placing part 221 includes a plurality of limiting holes 221 arranged on the container limiting plate 220. The container 222 can be placed and limited in the limiting hole 221, and the bottom of the container 222 can be supported on the upper surface of the transverse moving plate 210.
[0064] The limiting hole 221 can be a through hole penetrating through the upper and lower sides of the container limiting plate 220. The limiting hole 221 can be in a shape matching the cross-sectional shape of the container 222, for example, when the cross-sectional shape of the container 222 is circular, the limiting hole 221 can also be circular.
[0065] After the container 222 is placed in the limiting hole 221, the bottom of the container 222 can be supported on the upper surface of the transverse moving plate 210, and the side wall of the container 222 can abut against the hole wall of the limiting hole 221, thereby limiting the container 222.
[0066] In some embodiments, the first driving rod 330 can be a telescopic rod, which can be telescopic in the movement direction of the container carrying assembly 200. The transverse moving plate 210 can be fixedly connected with the telescopic rod. When the first motor 320 works, the first motor 320 can drive the telescopic rod to telescope, thereby driving the transverse moving plate 210 to move.
[0067] In some embodiments, the first driving rod 330 can be a screw rod, and a nut is sleeved on the screw rod. The nut is connected with the transverse moving plate 210. When the first motor 320 works, the first motor 320 can drive the screw rod to rotate, thereby driving the nut to slide along the screw rod, so as to drive the transverse moving plate 210 to move.
[0068] It can be understood that the first driving rod 330 can not be limited to being driven by the first motor 320. In other embodiments, the first driving rod 330 can also be driven by a pneumatic cylinder.
[0069] Referring to Figure 1 and Figure 4 In some embodiments, in order to simultaneously open or seal a plurality of containers 222, a container sealing assembly 500 is further arranged in the accommodating cavity. The container sealing assembly 500 is connected with the frame 100 through a second movement mechanism 400. The container sealing assembly 500 is arranged above the container carrying assembly 200. The container sealing assembly 500 comprises a sealing mechanism 530 corresponding to the container placing part 221 in the longitudinal direction Z. The second movement mechanism 400 is used to drive the sealing mechanism 530 to approach or move away from the container placing part 221, so as to make the sealing mechanism 530 sealingly cooperate with or be separated from the container port 2221 of the container 222.
[0070] When the pipetting operation is needed, the container sealing assembly 500 is first driven to rise by the second movement mechanism 400, so that the sealing mechanism 530 is separated from the container port 2221 of the container 222, and then the container carrying assembly 200 is driven to move out of the containing cavity by the first movement mechanism 300, so that the pipette extends into the container port 2221 to perform the pipetting. After the pipetting is completed, the container carrying assembly 200 is driven to move into the containing cavity by the first movement mechanism 300, and then the container sealing assembly 500 is driven to descend by the second movement mechanism 400, so that the sealing mechanism 530 is attached to the container port 2221 of the container 222. At this time, the plurality of containers 222 are again in a sealed state.
[0071] The solvent storage device provided by the embodiments of the present application can reduce the operation time of the pipetting process, because the plurality of containers 222 do not need to be opened and sealed one by one during the biochemical experiment, for example, the plurality of containers do not need to be taken out one by one, opened, pipetted, closed, and put back in, and the like.
[0072] Referring to Figure 4 In some embodiments, the second movement mechanism 400 includes a second guide assembly and a second driving assembly, and the container sealing assembly 500 is slidably connected to the second guide assembly. The second driving assembly is in transmission connection with the container sealing assembly 500 and is used to drive the container sealing assembly 500 to move. The second guide assembly can include two parallel longitudinal guide rails 410, and the two longitudinal guide rails 410 are arranged along the longitudinal direction Z and can be arranged on the inner side of the back plate 130 of the rack body 100. A sliding block can be mounted on the longitudinal guide rail 410, and the container sealing assembly 500 is fixed to the sliding block and can slide along the two longitudinal guide rails 410 with the sliding block.
[0073] In some embodiments, the second driving assembly includes a second motor 420 and a second driving rod 430 in transmission cooperation with the second motor 420. The second motor 420 is fixed to the rack body 100, and the second driving rod 430 is arranged along the longitudinal direction Z and located above the longitudinal moving plate 510 and fixedly connected to the upper side of the longitudinal moving plate 510.
[0074] In some embodiments, the second driving rod 430 can be a telescopic rod, the telescopic rod can be telescoped in the movement direction of the container sealing assembly 500, and the longitudinal moving plate 510 can be fixedly connected with the telescopic rod. When the second motor 420 works, the second motor 420 can drive the telescopic rod to telescope, thereby driving the longitudinal moving plate 510 to move.
[0075] In some embodiments, the second driving rod 430 can be a screw rod, a nut is sleeved on the screw rod, and the nut is connected with the longitudinal moving plate 510. When the second motor 420 works, the second motor 420 can drive the screw rod to rotate, thereby driving the nut to slide along the screw rod, so as to drive the longitudinal moving plate 510 to move.
[0076] It can be understood that the second driving rod 430 can not be limited to being driven by the second motor 420, and in other embodiments, the second driving rod 430 can also be driven by a pneumatic cylinder.
[0077] The second motor 420 of the embodiment can be a linear stepper motor, and the second motor 420 can drive the second driving rod 430 to move linearly along the axial direction thereof. The second motor 420 is fixedly arranged relative to the frame body 100, for example, the second motor 420 can be fixed to the frame body 100 by a fixing member.
[0078] In some embodiments, the solvent storage device further comprises a second limiting assembly arranged on the frame body 100, and the second limiting assembly is used for limiting the movement of the container sealing assembly 500, so that the container sealing assembly 500 is limited to a predetermined position in the longitudinal movement. The second limiting assembly can comprise a second photoelectric switch 131 and a limiting screw, the second photoelectric switch 131 is installed at a position close to the upper end of the longitudinal guide rail 410, and can limit the upward movement of the longitudinal moving plate 510; when the container sealing assembly 500 moves downward, the limiting screw can stop the container sealing assembly 500 at a set position, so that the descending height of the sealing mechanism 530 matches the height of the container, and then can be sealed with the container port 2221.
[0079] Referring to Figure 4 In some embodiments, the container sealing assembly 500 comprises a longitudinal moving plate 510 and a mounting plate 520 arranged on the longitudinal moving plate 510; the longitudinal moving plate 510 is slidably limited to the second guide assembly, and the second driving assembly is in transmission connection with the longitudinal moving plate 510; wherein a plurality of sealing mechanisms 530 are fixed to the mounting plate 520 and can move along the longitudinal direction Z with the mounting plate 520.
[0080] Referring to Figure 2 and Figure 5 In some embodiments, the arrangement form of the plurality of sealing mechanisms 530 on the mounting plate 520 is matched with the arrangement form of the plurality of container placing portions 221 on the container carrying assembly 200, so that the plurality of sealing mechanisms 530 and the plurality of container placing portions 221 correspond one by one. For example, when the arrangement form of the plurality of container placing portions 221 on the container carrying assembly 200 is a rectangular array, the arrangement form of the plurality of sealing mechanisms 530 on the mounting plate 520 is also a rectangular array. When the second movement mechanism 400 drives the longitudinal moving plate 510 to descend, the plurality of sealing mechanisms 530 on the mounting plate 520 can be in close contact with the plurality of container ports 2221 one by one, thereby realizing the simultaneous sealing or opening of the plurality of container ports 2221, avoiding the defect that the liquid transfer time is relatively long due to the need to open and seal the plurality of containers one by one in the related art, and improving the liquid transfer operation speed.
[0081] It can be understood that the first motor 320 and the transverse guide rail 310 can be arranged on the bottom plate 110 of the rack body 100, or can be arranged on the side plate 120 of the rack body 100. The second motor 420 and the longitudinal guide rail 410 can be arranged on the back plate 130 of the rack body 100, or can be arranged on the side plate 120 of the rack body 100, which is not specifically limited here.
[0082] Figure 6 is Figure 5 is a sectional view along A-A in FIG. 5; Figure 7 is Figure 6 is a partial enlarged view of B in FIG. 5.
[0083] Referring to Figure 4 , Figure 6 and Figure 7 In the embodiment, the sealing mechanism 530 includes a guide column 531 arranged on the mounting plate 520, the extension direction of the guide column 531 is along the longitudinal direction Z, a sealing part is sleeved on the guide column 531, the sealing part corresponds to the container placing part, and the sealing part is used for sealing cooperation with the container port 2221 of the container 222. When the mounting plate 520 is lowered to the set position, the sealing part can be in close contact with the edge of the container port 2221 and maintain a certain pressure.
[0084] In some embodiments, the sealing part is movably arranged along the axial direction of the guide column 531, and a resilient member 536 is sleeved on the guide column 531, the resilient member 536 is arranged between the mounting plate 520 and the sealing part, and the two ends of the resilient member 536 abut against the mounting plate 520 and the sealing part respectively. When the sealing part contacts the container port 2221, the resilient member 536 can exert a downward pressure on the sealing part, thereby ensuring that the contact between the sealing part and the container port 2221 is more stable.
[0085] In the embodiment, the resilient member 536 can be a spring sleeved on the guide column 531, but is not limited to a spring, and can also be other elastic parts having a similar function to the spring, such as a rubber ring.
[0086] In some embodiments, the sealing part includes a support sheet 532 sleeved on the guide column 531 and a sealing sheet 533 close to the support sheet 532, the two ends of the resilient member 536 abut against the mounting plate 520 and the support sheet 532 respectively, and the resilient member 536 can exert a downward pressure on the sealing sheet 533 through the support sheet 532, so that the pressing force between the sealing sheet 533 and the container port 2221 can be adjusted.
[0087] In some embodiments, the support sheet 532 can be made of a rigid material, for example, stainless steel; and the sealing sheet 533 can be made of a flexible material and a material having good acid and alkali corrosion resistance, for example, silica gel or PTFE (Poly tetra fluoroethylene).
[0088] With reference to the above embodiments, it can be seen that when the number of containers 222 is large, the plurality of containers 222 can be placed in layers by the multi-layer shelf body 100, and the container carrying assembly 200 and the container sealing assembly 500 of each layer of the shelf body 100 can be independently operated, so that pipetting can be performed in one or more layers of containers 222 according to actual needs, and the pipetting operation is more convenient. In addition, the shelf bodies 100 are detachably connected, and single-layer or multi-layer shelf bodies 100 can be selected according to actual needs, thereby meeting the needs of different biochemical sample preparation and analysis tests for the number of containers, and reducing the space occupation of the containers. Figure 7 In some embodiments, a plurality of mounting holes are formed in the mounting plate 520, and the guide columns 531 of the plurality of sealing mechanisms 530 are mounted in the mounting holes; the upper end of the guide column 531 is connected with the first fastener 534, and the first fastener 534 abuts against the upper side of the mounting plate 520; the lower end of the guide column 531 is connected with the second fastener 535, and the sealing component is clamped between the second fastener 535 and the elastic member 536, so that the guide column 531 is fixed to the mounting plate 520.
[0089] In the embodiment, the guide column 531 is in a hollow shape, and threaded holes are formed at the axial ends of the guide column 531, and the first fastener 534 and the second fastener 535 can be bolts matched with the threaded holes. In an implementation, the first fastener 534 can be an internal hexagonal bolt, and the second fastener 535 can be an external hexagonal bolt. Considering that the second fastener 535 will contact the container port 2221, in order to ensure that it has good acid and alkali corrosion resistance, the second fastener 535 is preferably an external hexagonal bolt made of PTFE material.
[0090] In some embodiments, in order to improve the stability of the cooperation between the first fastener 534 and the mounting plate 520, a first gasket 537 can be arranged between the first fastener 534 and the mounting plate 520, and in order to improve the stability of the cooperation between the second fastener 535 and the sealing component, a second gasket 538 can be arranged between the second fastener 535 and the sealing component. Considering that the second gasket 538 will contact the container port 2221, in order to ensure that it has good acid and alkali corrosion resistance, the second gasket 538 is preferably a gasket made of PTFE material.
[0091] With reference to the above embodiments, it can be seen that when the number of containers 222 is large, the plurality of containers 222 can be placed in layers by the multi-layer shelf body 100, and the container carrying assembly 200 and the container sealing assembly 500 of each layer of the shelf body 100 can be independently operated, so that pipetting can be performed in one or more layers of containers 222 according to actual needs, and the pipetting operation is more convenient. In addition, the shelf bodies 100 are detachably connected, and single-layer or multi-layer shelf bodies 100 can be selected according to actual needs, thereby meeting the needs of different biochemical sample preparation and analysis tests for the number of containers, and reducing the space occupation of the containers.
[0092] It can be understood that the frame body 100 can be composed of the bottom plate 110, the two side plates 120, the back plate 130 and the mounting plate 520, and the bottom plate 110, the two side plates 120, the back plate 130 and the mounting plate 520 define a containing cavity with adjustable space size. A top plate is fixedly arranged above the mounting plate 520, and a positioning member is arranged on the top plate, which is used for placing other containers or devices, such as a tray rack for placing test tubes, a tray rack for placing tip heads, and the like, so as to further improve the space utilization rate of the solvent storage device.
[0093] The above describes the solvent storage device of the embodiments of the present application, and accordingly, the present application also provides a pipetting system, which comprises a pipetting device and the solvent storage device as described in the above embodiments, and the pipetting device is used for pipetting from the container stored in the solvent storage device.
[0094] In the embodiment, the pipetting device can be a mechanical arm with a pipetting gun or a pipetting pump, which can realize full-automatic operation of the pipetting process. The structure of the solvent storage device is described in the above embodiments, and will not be described here.
[0095] The above has described the embodiments of the present application, and the above description is exemplary, is not exhaustive, and is not limited to the disclosed embodiments. Many modifications and changes are obvious to those skilled in the art without departing from the scope and spirit of the described embodiments. The selection of the terms used herein is intended to best explain the principles of the embodiments, practical application or improvement of the technology in the market, or to enable other ordinary skilled persons in the art to understand the embodiments disclosed herein.
Claims
1. A solvent storage device characterized in that: the solvent storage device is provided with at least one shelf body, the shelf body comprises a containing cavity with an opening, a container carrying assembly for carrying containers is arranged in the containing cavity, and the container carrying assembly is provided with a plurality of container placing portions; wherein the container carrying assembly is connected with the shelf body through a first movement mechanism, and the first movement mechanism is used to drive the container carrying assembly to move linearly at the opening; a container sealing assembly is arranged in the containing cavity, and the container sealing assembly is connected with the shelf body through a second movement mechanism; the container sealing assembly comprises sealing mechanisms corresponding to the container placing portions, the second movement mechanism is used to drive the sealing mechanisms to approach or move away from the container placing portions, so as to make the sealing mechanisms sealingly cooperate with or be separated from the container mouths of the containers; the second movement mechanism comprises a second guide assembly and a second driving assembly, the container sealing assembly further comprises a longitudinal moving plate and a mounting plate arranged on the longitudinal moving plate; the longitudinal moving plate is slidably connected with the second guide assembly, the second driving assembly is drivingly connected with the longitudinal moving plate, and the sealing mechanisms are arranged on the mounting plate; the sealing mechanisms comprise guide columns arranged on the mounting plate, sealing parts are arranged on the guide columns, the sealing parts correspond to the container placing portions and are used to abut the container mouths of the containers; the sealing parts are movably arranged along the axial direction of the guide columns, elastic members are sleeved on the guide columns, and the two ends of the elastic members abut against the mounting plate and the sealing parts, respectively.
2. The solvent storage device according to claim 1, characterized in that: the first movement mechanism comprises a first guide assembly and a first driving assembly, and the container carrying assembly is slidably connected with the first guide assembly; the first driving assembly is drivingly connected with the container carrying assembly and is used to drive the container carrying assembly to move.
3. The solvent storage device according to claim 2, characterized in that: the container carrying assembly comprises a transverse moving plate and a container limiting plate arranged above the transverse moving plate; the transverse moving plate is slidably connected with the first guide assembly, and the first driving assembly is drivingly connected with the transverse moving plate; the container placing portions comprise limiting holes formed on the container limiting plate, and the containers are placed in the limiting holes and supported on the transverse moving plate.
4. The solvent storage device according to claim 1, characterized in that: the sealing parts comprise support pieces sleeved on the guide columns and sealing pieces abutting against the support pieces, and the two ends of the elastic members abut against the mounting plate and the support pieces, respectively; the sealing pieces are located below the support pieces, and the lower surfaces of the sealing pieces are used to abut the container mouths of the containers.
5. The solvent storage device according to claim 1, characterized in that: The mounting plate is provided with a mounting hole, and the guide column is arranged in the mounting hole; the upper end of the guide column is connected with a first fastener, and the first fastener abuts against the upper side of the mounting plate; the lower end of the guide column is connected with a second fastener, the sealing component is clamped between the second fastener and the elastic member, and the second fastener abuts against the side of the sealing component away from the elastic member.
6. The solvent storage device of claim 3, wherein: The first driving assembly comprises a first motor and a first driving rod in transmission cooperation with the first motor, the first motor is fixed to the frame body, the first driving rod is arranged along the transverse direction and connected with the transverse moving plate to drive the transverse moving plate to move; and / or The second driving assembly comprises a second motor and a second driving rod in transmission cooperation with the second motor, the second motor is fixed to the frame body, the second driving rod is arranged along the longitudinal direction and connected with the longitudinal moving plate to drive the longitudinal moving plate to move.
7. The solvent storage device of claim 1, wherein: The container sealing assembly is provided with a plurality of sealing mechanisms, and the plurality of sealing mechanisms correspond to the plurality of container placing portions one by one.
8. The solvent storage device of claim 3, wherein: The container limiting plate and the transverse moving plate are arranged in vertical direction with a spacing; When the container is placed in the limiting hole, the bottom of the container is supported on the upper surface of the transverse moving plate, and the outer side wall of the container abuts against the hole wall of the limiting hole.
9. The solvent storage device of claim 1, wherein: The frame body comprises a bottom plate, a top plate, a side plate and a back plate connected between the bottom plate and the top plate, the bottom plate, the top plate, the side plate and the back plate define the accommodating cavity, and the opening is arranged on the side opposite to the back plate.
10. The solvent storage device of any one of claims 1-9, wherein: The frame body is provided with multiple layers, and the multiple layers of the frame body are fixedly combined or detachably combined into one, and the openings of the accommodating cavities of the multiple layers of the frame body are arranged on the same side of the frame body.
11. A pipetting system, characterized in that The solvent storage device as claimed in any one of claims 1-10 is combined with a pipetting device, and the pipetting device is used for pipetting from the container stored in the solvent storage device.
Citation Information
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