Pharmaceutical equipment, pharmaceutical method and medicine of brivaracetam injection

Abstract

The application discloses a kind of brivaracetam injection pharmaceutical equipment, pharmaceutical method and its medicine, specifically related to pharmaceutical technical field, the rolling plate of the rolling assembly of the present application, the ball on the surface of rolling plate, the solid medicinal materials on the bottom of placing barrel are rolled at multiple angles, so that the drug liquid in solid medicinal materials is fully rolled out, then better complete the separation between drug liquid and solid medicinal materials.In addition, the present application also includes pharmaceutical equipment, wherein the medicine manufactured by the brivaracetam injection pharmaceutical equipment, brivaracetam is a levetiracetam analogue, and the affinity for SV2A is 13 times that of levetiracetam, the dosage is about one tenth of levetiracetam, the side effects are lower than levetiracetam, and the dosage is usually 25-100mg / day.The brivaracetam injection of the present application is stable in nature, safe and effective.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, and in particular to a pharmaceutical apparatus, pharmaceutical method and pharmaceutical preparation for briracetam injection. Background Technology

[0002] Research on briracetam injection formulation is urgently needed. Existing pharmaceutical equipment includes dryers, pulverizers, dispensing tanks, and separation equipment. The inventors have discovered that in the manufacture of briracetam injection for the treatment of epilepsy, solid medicinal materials are decocted, and then the decocted liquid is separated from the solid materials using separation equipment before further pharmaceutical equipment is used to complete the manufacturing of briracetam injection. During the separation of the liquid and solid materials, the liquid cannot be completely extracted from the solid materials, resulting in some solid materials adsorbing residual liquid, and the liquid often contains some solid material residue, thus affecting the separation efficiency. This application provides a pharmaceutical equipment for briracetam injection to solve the above-mentioned problems. Summary of the Invention

[0003] This invention addresses the problem that during the separation of liquid and solid medicinal materials, the liquid in the solid medicinal materials cannot be completely removed, resulting in some solid medicinal materials adsorbing residual liquid and some solid medicinal material residue remaining in the liquid, thus affecting the separation effect. The invention provides a pharmaceutical equipment, pharmaceutical method, and pharmaceutical preparation for bricerazan injection.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: a pharmaceutical equipment, pharmaceutical method, and pharmaceutical preparation for briracetam injection, comprising an outer frame and a feed hole formed on the surface of a middle block. A controller is provided on the surface of the outer frame, and a water inlet pipe is provided on the side of the outer frame near the controller. A placement bucket is provided at the upper end of the outer frame, and the outlet of the water inlet pipe is located on the inner wall of the placement bucket. A water outlet pipe is provided on the surface of the placement bucket. A collection box is provided at the end of the outer frame away from the controller, and a water pump is provided at the upper end of the collection box. One end of the water pump is fixedly connected to the water outlet pipe. A crushing assembly is provided inside the placement bucket to crush and separate the liquid from the solid medicinal material. A pushing assembly is provided at the upper end of the middle block to quickly push the solid medicinal material into the feed hole. A filtration and cleaning assembly is provided inside the outer frame to filter and separate the crushed solid medicinal material and the liquid.

[0005] The aforementioned components achieve the following effect: In the manufacture of bricillin injection for epilepsy treatment, solid medicinal materials are decocted, then poured into a storage tank. A controller then controls the components of the pharmaceutical equipment. A pushing component pushes the remaining solid medicinal material from the upper part of the intermediate block into the feed hole. The solid medicinal material then reaches the crushing component, where the liquid is crushed out. A filtration and cleaning component then filters and separates the crushed solid medicinal material and liquid, which are then discharged through the water inlet pipe. Water is added to the placement tank, and the dregs are cleaned. Then, the water pump is started through the controller, and the water pump and the outlet pipe draw water containing dregs into the collection tank for dreg collection. The dregs inside the equipment are then cleaned. The filter cleaning component cleans the dregs in the secondary filtered liquid, and the cleaned dregs also enter the collection tank. Then, the liquid outlet pipe on the support leg of the outer frame is used to export the separated liquid, which is then transferred to subsequent pharmaceutical equipment for use. Finally, the manufacturing of bricetam injection is completed.

[0006] Preferably, the compaction assembly includes bolts, which are threadedly connected to the outer frame. A mounting plate is threadedly connected to the surface of the bolts. A bracket is fixedly connected to the surface of the mounting plate. A first electric telescopic rod is fixedly connected to the end of the bracket away from the mounting plate. A motor is fixedly connected to the output end of the first electric telescopic rod. A first rotating rod is fixedly connected to the output end of the motor. A middle block is fixedly connected to the end of the first rotating rod away from the motor. A feed hole is formed on the surface of the middle block. Four first fixing plates are fixedly connected to the end of the middle block away from the first rotating rod. The four first fixing plates are arranged in pairs. A second rotating rod is rotatably connected inside each pair of first fixing plates. A first connecting plate is fixedly connected to the surface of the second rotating rod. A compaction plate is fixedly connected to the end of the first connecting plate away from the second rotating rod. A plurality of ball bearings are embedded in the surface of the compaction plate. A first spring is fixedly connected to the ends of the two first connecting plates that are close to each other.

[0007] The effect achieved by the above components is as follows: When using the crushing assembly to separate the medicinal liquid from solid medicinal materials, first, the mounting plate is placed on the outer frame surface, and then the bolts are rotated to fix the mounting plate to the outer frame surface. Then, the first electric telescopic rod on the bracket is positioned at the center above the placement tank. Then, the first electric telescopic rod is activated by the controller, causing the output end of the first electric telescopic rod to drive the motor closer to the placement tank. Then, the motor drives the first rotating rod and the middle block to reach the inside of the placement tank. At this time, the crushing plate is also located inside the placement tank. Then, the solid medicinal materials are placed into the placement tank, and then the solid medicinal materials reach the bottom of the placement tank through the feed hole on the surface of the middle block. At this time, the solid medicinal materials are located between the placement tank and the crushing plate. Then, the first electric telescopic rod is activated by the controller. The rolling balls on the surface of the grinding plate come into contact with the solid medicinal material. At this time, the second rotating rod on the surface of the first fixed plate will drive the first connecting plate to rotate. The first spring at the first connecting plate will be stretched, and then the rolling balls will crush the solid medicinal material. Then, the motor is started by the controller, which drives the first rotating rod to rotate. The rotation direction is forward for a period of time and then reverse for a period of time. Then the first rotating rod drives the middle block to rotate, and then the grinding plate will drive the rolling balls to rotate. Then the output end of the first electric telescopic rod will reciprocate continuously. At this time, the two grinding plates will continuously move closer and further away from each other and will continue to rotate. Then the rolling balls on the grinding plate crush the solid medicinal material at the bottom of the container at multiple angles, so that the medicinal liquid in the solid medicinal material is crushed out.

[0008] Preferably, a plurality of first bristles are fixedly connected to the end of the rolling plate away from the first connecting plate, and a scraper is fixedly connected in the middle of the plurality of first bristles.

[0009] The effect achieved by the above components is as follows: when the rollers on the surface of the grinding plate crush the solid medicinal materials, the first bristles and scraper on the grinding plate clean the solid medicinal material residue on the upper part of the inner wall of the placement bucket, so as to avoid the solid medicinal material residue adhering to the upper part of the inner wall of the placement bucket, which would affect the effect of subsequent filtration and cleaning components.

[0010] Preferably, a reinforcing plate is fixedly connected to one side of the first connecting plate, and the end of the reinforcing plate away from the first connecting plate is fixedly connected to the rolling plate.

[0011] The effect achieved by the above-mentioned components is as follows: when the ball bearings on the surface of the grinding plate crush the solid medicinal material, the connection strength between the first connecting plate and the grinding plate can be improved by the reinforcing plate, so as to avoid the change of the angle at the connection between the grinding plate and the first connecting plate, which would affect the use effect of the grinding plate, thereby improving the use effect of the grinding plate.

[0012] Preferably, bearings are fixedly connected to both ends of the second rotating rod, and the outer ring of the bearing is fixedly connected to the first fixed plate.

[0013] The effect achieved by the above components is that when the second rotating rod rotates inside the first fixed plate, the bearing can reduce the friction between the first rotating rod and the first fixed plate, making it easier for the rolling plate to change position.

[0014] Preferably, an operating block is fixedly connected to the surface of the bolt, and the surface of the operating block is provided with a plurality of anti-slip protrusions.

[0015] The effect achieved by the above components is that when it is necessary to manually rotate the bolts to fix the mounting plate, the operating block can be used to increase the friction between the operator's hand and the bolts, making it easier for the operator to rotate the bolts to fix the mounting plate.

[0016] Preferably, a positioning block is fixedly connected to the surface of the outer frame, and the size of the positioning block is adapted to the size of the mounting plate.

[0017] The effect achieved by the above components is that when the mounting plate is placed on the outer frame surface, the positioning block can quickly position the mounting plate on the outer frame surface, thereby facilitating the operator to fix the mounting plate with bolts later.

[0018] Preferably, the pushing component includes a slide rail, which is fixedly connected to an intermediate block. A sliding block is slidably connected inside the slide rail. A pushing plate is fixedly connected to one side of the sliding block. A second spring is fixedly connected to the end of the slide rail near the sliding block. The end of the second spring away from the slide rail is fixedly connected to the sliding block. A pull rope is fixedly connected to the surface of the sliding block. The end of the pull rope away from the sliding block is fixedly connected to a first rotating rod. A baffle plate is fixedly connected to the end of the slide rail near the spring. One end of the baffle plate is fixedly connected to the sliding block.

[0019] The effect achieved by the above components is as follows: when some solid medicinal materials do not enter the feed hole at the upper end of the middle block, when the first rotating rod rotates, the pull rope will be wound up by the first rotating rod, and then the sliding block will slide inside the slide rail, and then drive the push plate to approach the feed hole on the surface of the middle block. At this time, the second spring will be stretched, and the shielding cloth will also be stretched, so that the shielding cloth will always shield and protect the second spring, preventing the solid medicinal materials from getting stuck in the gap of the second spring. Then the push plate will drive some of the solid medicinal materials at the upper end of the middle block into the feed hole, thereby increasing the amount of solid medicinal materials reaching the lower end of the crushing plate. When the motor drives the first rotating rod to reverse, the wound pull rope will be released, and then the second spring will reset, driving the push plate back to the initial position. At this time, the shielding cloth is in a folded state.

[0020] Preferably, the filtration and cleaning assembly includes a plurality of filter holes formed at the bottom of the placement bucket, a second fixing plate fixedly connected to the inside of the outer frame, a second electric telescopic rod fixedly connected to the surface of the second fixing plate, a lifting plate fixedly connected to the output end of the second electric telescopic rod, a plurality of filling columns fixedly connected to the surface of the lifting plate, the size of the plurality of filling columns being adapted to the size of the plurality of filter holes on the surface of the placement bucket, a placement plate fixedly connected to the side of the outer frame near the controller, a third electric telescopic rod fixedly connected to the surface of the placement plate, a moving block fixedly connected to the output end of the third electric telescopic rod, a second brush fixedly connected to the surface of the moving block, a filter plate fixedly connected to the inside of the outer frame, the filter plate being located below the second brush on the surface of the moving block, the size of the filter plate being adapted to the size of the moving plate, a scraper fixedly connected to the end of the moving block away from the second electric telescopic rod, and a pointed post fixedly connected to the surface of the scraper.

[0021] The effect achieved by the above components is as follows: After the liquid medicine is crushed out from the solid medicinal material, the controller can activate the second electric telescopic rod on the surface of the second fixed plate, which then drives the lifting plate to descend. The filling column on the surface of the lifting plate will then disengage from the filter hole on the surface of the placement bucket. The crushed liquid medicine will then leave the placement bucket through the filter hole. After the liquid medicine flows out of the placement bucket, the second electric telescopic rod is activated again, causing the lifting plate to rise. The filling column will then block the filter hole on the surface of the placement plate again, restoring the placement bucket to its normal state. The liquid medicine will then undergo secondary filtration through the filter plate. The liquid medicine will then leave the outer frame through the outlet pipe. The third electric telescopic rod on the placement plate is then activated, causing the moving block to move on the surface of the filter plate. The shovel and pointed column on the third electric telescopic rod will then shovel and disperse the solid medicinal residue on the filter surface. The second brush will then clean the solid medicinal residue. Finally, after the moving plate reaches the inside of the collection box, the collection of the fixed medicinal residue is completed.

[0022] Preferably, the process includes the following steps: S1. When manufacturing bricetan injection for drug treatment of epilepsy, solid medicinal materials are decocted, and then the mounting plate is placed on the surface of the outer frame. Then, the bolts are rotated to fix the mounting plate to the surface of the outer frame. Then, the first electric telescopic rod on the bracket is located at the center above the placement barrel. Then, the first electric telescopic rod is started by the controller, so that the output end of the first electric telescopic rod drives the motor to approach the placement barrel. Then, the motor drives the first rotating rod and the middle block to reach the inside of the placement barrel. At this time, the crushing plate is also located inside the placement barrel.

[0023] S2. Then, the decocted solid medicinal materials are poured into the placement bucket. The solid medicinal materials reach the bottom of the placement bucket through the feed hole on the surface of the middle block. At this time, the solid medicinal materials are located between the placement bucket and the crushing plate. Then, the controller starts the first electric telescopic rod, so that the ball bearings on the surface of the crushing plate come into contact with the solid medicinal materials. At this time, the second rotating rod on the surface of the first fixed plate will drive the first connecting plate to rotate. The first spring at the first connecting plate will be stretched. Then the ball bearings crush the solid medicinal materials. Then, the controller starts the motor, so that the motor drives the first rotating rod to rotate. The rotation direction is forward for a period of time and reverse for a period of time. Then the first rotating rod drives the middle block to rotate. Then the crushing plate will drive the ball bearings to rotate. Then the output end of the first electric telescopic rod will continuously reciprocate. At this time, the two crushing plates will continuously move closer and further away from each other and will continuously rotate. Then the ball bearings on the crushing plate crush the solid medicinal materials at the bottom of the placement bucket at multiple angles, so that the medicinal liquid in the solid medicinal materials is crushed out.

[0024] S3. When some solid medicinal materials do not enter the feed hole at the upper end of the middle block, when the first rotating rod rotates, the pull rope will be wound up by the first rotating rod, and then the sliding block will slide inside the slide rail, and then drive the push plate to approach the feed hole on the surface of the middle block. At this time, the second spring will be stretched, and the shielding cloth will also be stretched, so that the shielding cloth will always shield and protect the second spring to prevent the solid medicinal materials from getting stuck in the gap of the second spring. Then the push plate will drive some solid medicinal materials at the upper end of the middle block into the feed hole, thereby improving the efficiency of the solid medicinal materials reaching the lower end of the crushing plate. When the motor drives the first rotating rod to reverse, the wound pull rope will be released, and then the second spring will reset, driving the push plate back to the initial position. At this time, the shielding cloth is in a folded state.

[0025] S4. After the liquid medicine is crushed out from the solid medicinal material, the second electric telescopic rod on the surface of the second fixed plate can be activated by the controller. The second electric telescopic rod will then drive the lifting plate to descend. The filling column on the surface of the lifting plate will then disengage from the filter hole on the surface of the placement bucket. The crushed liquid medicine will then leave the placement bucket through the filter hole. After the liquid medicine flows out of the placement bucket, the second electric telescopic rod will be activated again to raise the lifting plate. The filling column will then block the filter hole on the surface of the placement plate again, allowing the placement bucket to return to normal. The liquid medicine will then undergo secondary filtration through the filter plate. The liquid medicine will then leave the outer frame through the liquid outlet pipe. The third electric telescopic rod on the placement plate will then be activated to drive the moving block to move on the surface of the filter plate. The shovel and the pointed column on the third electric telescopic rod will then shovel and disperse the solid medicinal residue on the filter surface. The second brush will then clean the solid medicinal residue. After the moving plate reaches the inside of the collection box, the collection of the fixed medicinal residue will be completed.

[0026] S5. For the solid residue remaining inside the storage container, water can be added to the storage container through the water inlet pipe to clean the residue. Then, the water pump is started through the controller, and the water pump and water outlet pipe draw the water containing the residue into the collection tank to collect the residue, thus completing the cleaning of the residue inside the storage container.

[0027] Briracetam is a drug that is an analogue of levetiracetam. It has 13 times the affinity for SV2A as levetiracetam, and the dosage is about one-tenth that of levetiracetam. It has fewer side effects than levetiracetam, and the dosage is usually 25-100 mg / day.

[0028] In summary, the beneficial effects of the present invention are as follows: the crushing plate of the crushing assembly allows the rolling balls on the surface of the crushing plate to crush the solid medicinal materials placed at the bottom of the bucket from multiple angles, so that the medicinal liquid in the solid medicinal materials is fully crushed out, and then the separation between the medicinal liquid and the solid medicinal materials is better achieved.

[0029] The filter cleaning component performs secondary filtration of the drug residue in the liquid medicine, and can also clean up the filtered residue to prevent it from affecting the subsequent use of the equipment.

[0030] By using the pusher component, the pusher plate can drive some of the solid medicinal materials at the top of the middle block into the feed hole, thereby increasing the amount of solid medicinal materials reaching the bottom of the crushing plate. Attached Figure Description

[0031] Figure 1 This is a three-dimensional schematic diagram of the present invention.

[0032] Figure 2 This is the present invention. Figure 1 Cross-sectional view.

[0033] Figure 3 This is a three-dimensional structural diagram of the mounting plate of the present invention.

[0034] Figure 4 This is the invention Figure 2 A partial three-dimensional structural diagram.

[0035] Figure 5 This is a three-dimensional structural diagram of the middle block of the present invention.

[0036] Figure 6 This is the present invention. Figure 5 A partial three-dimensional structural diagram.

[0037] Figure 7 This is a three-dimensional structural diagram of the second fixing plate of the present invention.

[0038] Figure 8 This is a three-dimensional structural diagram of the filter plate of the present invention.

[0039] Figure 9 This is a three-dimensional structural diagram of the push component 3 of the present invention.

[0040] Figure 10 This is the present invention. Figure 9 Enlarged view of point A.

[0041] Explanation of reference numerals in the attached drawings: 1. Outer frame; 2. Compactor assembly; 201. Bolt; 202. Mounting plate; 203. Bracket; 204. First electric telescopic rod; 205. Motor; 206. First rotating rod; 207. Intermediate block; 208. Feed hole; 209. First fixing plate; 210. Second rotating rod; 211. First connecting plate; 212. Compactor plate; 213. Ball bearing; 214. First bristles; 215. Scraper; 216. Reinforcing plate; 217. Bearing; 218. Operating block; 219. Positioning block; 220. First spring; 3. Pushing assembly; 31. Slide rail; 32. Sliding block; 33. Push plate; 34. Second spring; 35. Pull rope; 36. Covering cloth; 4. Filter cleaning assembly; 401. Filter hole; 402. Second fixing plate; 403. Second electric telescopic rod; 404. Lifting plate; 405. Filling column; 406. Placement plate; 407. Third electric telescopic rod; 408. Moving block; 409. Second bristles; 410. Filter plate; 411. Shovel; 412. Pointed column; 5. Controller; 6. Water inlet pipe; 7. Placement bucket; 8. Water outlet pipe; 9. Water pump; 10. Collection box; 11. Liquid outlet pipe; 12. Support leg. Detailed Implementation

[0042] Reference Figure 1-10As shown, this embodiment discloses a pharmaceutical equipment, pharmaceutical method, and drug for briracetam injection, including an outer frame 1 and a feed hole 208 opened on the surface of a middle block 207. A controller 5 is provided on the surface of the outer frame 1, and a water inlet pipe 6 is provided on the side of the outer frame 1 near the controller 5. A placement tank 7 is provided at the upper end of the outer frame 1, and the outlet of the water inlet pipe 6 is located on the inner wall of the placement tank 7. A water outlet pipe 8 is provided on the surface of the placement tank 7. A collection box 10 is provided at the end of the outer frame 1 away from the controller 5. A water pump 9 is provided at the upper end of the collection box 10, and one end of the water pump 9 is fixedly connected to the water outlet pipe 8. A crushing component 2 is provided inside the placement tank 7. The crushing component 2 crushes and separates the liquid from the solid medicinal material. A pushing component 3 is provided at the upper end of the middle block 207. The pushing component 3 quickly pushes the solid medicinal material into the feed hole 208. A filtration and cleaning component 4 is provided inside the outer frame 1. The filtration and cleaning component 4 filters and separates the crushed solid medicinal material and liquid. In the manufacture of bricillin injection for the treatment of epilepsy, solid medicinal materials are decocted and then poured into the placement tank 7. The controller 5 controls the components of the pharmaceutical equipment, and the pushing component 3 pushes the remaining solid medicinal material on the upper part of the intermediate block 207 into the feed hole 208. The solid medicinal material then reaches the crushing component 2, where the liquid is crushed out. The filtration and cleaning component 4 filters and separates the crushed solid medicinal material and liquid, and then the liquid is fed into the placement tank 7 through the water inlet pipe 6. Water is added, and then the dregs are cleaned. Then, the water pump 9 is started through the controller 5. The water pump 9 and the water outlet pipe 8 draw water containing dregs into the collection tank 10 to collect the dregs. Then, the dregs inside the equipment are cleaned. Then, the filter cleaning component 4 cleans the dregs in the secondary filtered liquid, so that the cleaned dregs also enter the collection tank 10. Then, the liquid outlet pipe 11 at the support leg 12 on the outer frame 1 is used to export the separated liquid. Then, the liquid is transferred to subsequent pharmaceutical equipment for use. Finally, the manufacturing of bricetam injection is completed.

[0043] Reference Figure 1-6As shown, this embodiment discloses a compaction assembly 2 including bolts 201, which are threadedly connected to the outer frame 1. A mounting plate 202 is threadedly connected to the surface of the bolts 201. A bracket 203 is fixedly connected to the surface of the mounting plate 202. A first electric telescopic rod 204 is fixedly connected to the end of the bracket 203 away from the mounting plate 202. A motor 205 is fixedly connected to the output end of the first electric telescopic rod 204. A first rotating rod 206 is fixedly connected to the output end of the motor 205. An intermediate block 207 is fixedly connected to the end of the first rotating rod 206 away from the motor 205. The surface of the intermediate block 207 is open... The device has a feed hole 208. Four first fixing plates 209 are fixedly connected to the end of the middle block 207 away from the first rotating rod 206. The four first fixing plates 209 are arranged in pairs. A second rotating rod 210 is rotatably connected inside each pair of first fixing plates 209. A first connecting plate 211 is fixedly connected to the surface of the second rotating rod 210. A rolling plate 212 is fixedly connected to the end of the first connecting plate 211 away from the second rotating rod 210. A number of balls 213 are embedded on the surface of the rolling plate 212. A first spring 220 is fixedly connected to the end of the two first connecting plates 211 that are close to each other.

[0044] Reference Figure 1-6As shown in the figure, this embodiment discloses that when using the crushing assembly 2 to separate the medicinal liquid from solid medicinal materials, the mounting plate 202 is first placed on the surface of the outer frame 1, and then the bolt 201 is rotated to fix the mounting plate 202 to the surface of the outer frame 1. Then, the first electric telescopic rod 204 on the bracket 203 is positioned at the center above the placement tank 7. Then, the first electric telescopic rod 204 is activated by the controller 5, so that the output end of the first electric telescopic rod 204 drives the motor 205 to approach the placement tank 7. Then, the motor 205 drives the first rotating rod 206 and the intermediate block 207 to reach the inside of the placement tank 7. At this time, the crushing plate 212 is also located inside the placement tank 7. Then, the solid medicinal materials are put into the placement tank 7, and then the solid medicinal materials reach the bottom of the placement tank 7 through the feed hole 208 on the surface of the intermediate block 207. At this time, the solid medicinal materials are located between the placement tank 7 and the crushing plate 212. Then, the first electric telescopic rod 204 is activated by the controller 5. The ball bearings 213 on the surface of the crushing plate 212 come into contact with the solid medicinal material. At this time, the second rotating rod 210 on the surface of the first fixed plate 209 will drive the first connecting plate 211 to rotate. The first spring 220 at the first connecting plate 211 will be stretched. Then the ball bearings 213 crush the solid medicinal material. Then the controller 5 starts the motor 205, which drives the first rotating rod 206 to rotate. The rotation direction is forward for a period of time and reverse for a period of time. Then the first rotating rod 206 drives the middle block 207 to rotate. Then the crushing plate 212 will drive the ball bearings 213 to rotate. Then the output end of the first electric telescopic rod 204 will reciprocate continuously. At this time, the two crushing plates 212 will continuously move closer and further away from each other and will continuously rotate. Then the ball bearings 213 on the crushing plate 212 crush the solid medicinal material at the bottom of the placement bucket 7 at multiple angles, so that the medicinal liquid in the solid medicinal material is crushed out.

[0045] Reference Figure 1-6As shown, this embodiment discloses that a plurality of first bristles 214 are fixedly connected to one end of the crushing plate 212 away from the first connecting plate 211, and a scraper 215 is fixedly connected in the middle of the plurality of first bristles 214. When the rollers 213 on the surface of the crushing plate 212 crush the solid medicinal material, the first bristles 214 and the scraper 215 on the crushing plate 212 clean the solid medicinal material residue on the upper part of the inner wall of the placement bucket 7, so as to avoid the residue of solid medicinal material adhering to the upper part of the inner wall of the placement bucket 7, which would affect the use effect of the subsequent filtration and cleaning component 4. A reinforcing plate 216 is fixedly connected to one side of the first connecting plate 211, and the end of the reinforcing plate 216 away from the first connecting plate 211 is fixedly connected to the crushing plate 212. When the ball bearings 213 on the surface of the grinding plate 212 grind the solid medicinal material, the reinforcing plate 216 can be used to improve the connection strength between the first connecting plate 211 and the grinding plate 212, preventing the angle at the connection point between the grinding plate 212 and the first connecting plate 211 from changing and affecting the performance of the grinding plate 212, thereby improving the performance of the grinding plate 212. Bearings 217 are fixedly connected to both ends of the second rotating rod 210, and the outer ring of the bearing 217 is fixedly connected to the first fixed plate 209. When the second rotating rod 210 rotates inside the first fixed plate 209, the bearings 217 can reduce the friction between the first rotating rod and the first fixed plate 209, making it easier for the grinding plate 212 to change position.

[0046] Reference Figure 1-6 As shown, this embodiment discloses an operating block 218 fixedly connected to the surface of the bolt 201. The surface of the operating block 218 has several anti-slip protrusions. When it is necessary to manually rotate the bolt 201 to fix the mounting plate 202, the operating block 218 can increase the friction between the operator's hand and the bolt 201, making it easier for the operator to rotate the bolt 201 to fix the mounting plate 202. A positioning block 219 is fixedly connected to the surface of the outer frame 1, and the size of the positioning block 219 is adapted to the size of the mounting plate 202. When the mounting plate 202 is placed on the surface of the outer frame 1, the positioning block 219 can be used to quickly position the mounting plate 202 on the surface of the outer frame 1, thereby facilitating the operator to subsequently fix the mounting plate 202 using the bolt 201.

[0047] Reference Figure 1-4 and Figure 7 as well as Figure 8As shown, this embodiment discloses a filter cleaning assembly 4 including a plurality of filter holes 401 formed at the bottom of the placement tank 7. A second fixing plate 402 is fixedly connected inside the outer frame 1. A second electric telescopic rod 403 is fixedly connected to the surface of the second fixing plate 402. A lifting plate 404 is fixedly connected to the output end of the second electric telescopic rod 403. A plurality of filling columns 405 are fixedly connected to the surface of the lifting plate 404. The size of the plurality of filling columns 405 is adapted to the size of the plurality of filter holes 401 on the surface of the placement tank 7. A placement tank 401 is fixedly connected to the side of the outer frame 1 near the controller 5. A plate 406 is placed on a surface, and a third electric telescopic rod 407 is fixedly connected to the surface of the plate 406. A moving block 408 is fixedly connected to the output end of the third electric telescopic rod 407. A second brush bristle 409 is fixedly connected to the surface of the moving block 408. A filter plate 410 is fixedly connected inside the outer frame 1. The filter plate 410 is located below the second brush bristle 409 on the moving surface. The size of the filter plate 410 is adapted to the size of the moving plate. A scraper 411 is fixedly connected to the end of the moving block 408 away from the second electric telescopic rod 403. A pointed post 412 is fixedly connected to the surface of the scraper 411. After the medicinal liquid is crushed out from the solid medicinal material, the controller 5 can activate the second electric telescopic rod 403 on the surface of the second fixed plate 402. This causes the second electric telescopic rod 403 to lower the lifting plate 404. The filling column 405 on the surface of the lifting plate 404 then disengages from the filter hole 401 on the surface of the placement tank 7. The crushed medicinal liquid then flows out of the placement tank 7 through the filter hole 401. After the medicinal liquid flows out of the placement tank 7, the second electric telescopic rod 403 is activated again, causing the lifting plate 404 to rise. The filling column 405 then blocks the filter hole 401 on the surface of the placement plate 406 again. The placement tank 7 is restored to normal, and the medicine is filtered again through the filter plate 410. The medicine then leaves the outer frame 1 through the outlet pipe 11. The third electric telescopic rod 407 on the placement plate 406 is activated, which drives the moving block 408 to move on the surface of the filter plate 410. The scraper 411 and the pointed column 412 on the third electric telescopic rod 407 scrape and disperse the solid medicine residue on the filter surface. The second brush 409 cleans the solid medicine residue. After the moving plate reaches the inside of the collection box 10, the collection of the fixed medicine residue is completed.

[0048] Reference Figure 1-4 and Figure 9 as well as Figure 10As shown, this embodiment discloses a push assembly 3 including a slide rail 31, which is fixedly connected to an intermediate block 207. A sliding block 32 is slidably connected inside the slide rail 31. A push plate 33 is fixedly connected to one side of the sliding block 32. A second spring 34 is fixedly connected to one end of the slide rail 31 near the sliding block 32. The end of the second spring 34 away from the slide rail 31 is fixedly connected to the sliding block 32. A pull rope 35 is fixedly connected to the surface of the sliding block 32. The end of the pull rope 35 away from the sliding block 32 is fixedly connected to a first rotating rod 206. A baffle plate is fixedly connected to one end of the slide rail 31 near the spring. One end of the baffle plate is fixedly connected to the sliding block 32. When some solid medicinal materials do not enter the feed hole 208 at the upper end of the middle block 207, when the first rotating rod 206 rotates, the pull rope 35 will be wound up by the first rotating rod 206, and then the sliding block 32 will slide inside the slide rail 31, and then drive the push plate 33 to approach the feed hole 208 on the surface of the middle block 207. At this time, the second spring 34 will be stretched, and the shielding cloth 36 will also be stretched, so that the shielding cloth 36 will always shield and protect the second spring 34, preventing the solid medicinal materials from getting stuck in the gap of the second spring 34. Then the push plate 33 will drive some of the solid medicinal materials at the upper end of the middle block 207 into the feed hole 208, thereby improving the efficiency of the solid medicinal materials reaching the lower end of the crushing plate 212. When the motor 205 drives the first rotating rod 206 to reverse, the wound pull rope 35 will be released, and then the second spring 34 will reset, driving the push plate 33 back to the initial position. At this time, the shielding cloth 36 is in a folded state.

[0049] Briracetam is a drug that is an analogue of levetiracetam. It has 13 times the affinity for SV2A as levetiracetam, and the dosage is about one-tenth that of levetiracetam. It has fewer side effects than levetiracetam, and the dosage is usually 25-100 mg / day.

[0050] This technical solution enables the development of a stable, safe, and effective bricerazan injection, and also develops a quality control method for this injection, enabling its commercial production and filling the domestic gap in bricerazan injection.

[0051] The working principle is as follows: When manufacturing bricetan injection for epilepsy treatment, solid medicinal materials are decocted. Then, mounting plate 202 is placed on the surface of outer frame 1, and bolt 201 is rotated to fix mounting plate 202 to the surface of outer frame 1. The first electric telescopic rod 204 on bracket 203 is positioned at the center above the placement tank 7. The controller 5 activates the first electric telescopic rod 204, causing its output end to drive motor 205 closer to the placement tank 7. Motor 205 then drives the first rotating rod 206 and intermediate block 207 to the inside of the placement tank 7. At this time, the crushing plate 212 is also located inside the placement tank 7. The decocted solid medicinal materials are then poured into the placement tank 7. The medicinal materials reach the bottom of the placement barrel 7 through the feed hole 208 on the surface of the intermediate block 207. At this time, the solid medicinal materials are located between the placement barrel 7 and the crushing plate 212. Then, the controller 5 activates the first electric telescopic rod 204, causing the ball bearings 213 on the surface of the crushing plate 212 to contact the solid medicinal materials. At this time, the second rotating rod 210 on the surface of the first fixed plate 209 will drive the first connecting plate 211 to rotate, and the first spring 220 at the first connecting plate 211 will be stretched. Then, the ball bearings 213 crush the solid medicinal materials. Then, the controller 5 activates the motor 205, causing the motor 205 to drive the first rotating rod 206 to rotate. The rotation direction is forward for a period of time and reverse for a period of time. Then, the first rotating rod 206 drives the intermediate block 207 to rotate. The rear crushing plate 212 drives the ball bearings 213 to rotate, causing the output end of the first electric telescopic rod 204 to reciprocate continuously. During this time, the two crushing plates 212 continuously move closer and further apart, rotating constantly. The ball bearings 213 on the crushing plate 212 then crush the solid medicinal materials at the bottom of the container 7 from multiple angles, causing the medicinal liquid to be squeezed out. When some solid medicinal materials do not enter the feed hole 208 at the upper end of the middle block 207, when the first rotating rod 206 rotates, the pull rope 35 is wound up by the first rotating rod 206. Then, the sliding block 32 slides inside the slide rail 31, driving the pusher plate 33 closer to the feed hole 208 on the surface of the middle block 207. At this time, the second spring 34 is stretched, and the shielding cloth 36 also... The shielding cloth 36 will be stretched to continuously shield the second spring 34, preventing solid medicinal materials from getting stuck in the gap of the second spring 34. Then, the pusher plate 33 will drive part of the solid medicinal materials at the upper end of the middle block 207 into the feed hole 208, thereby improving the efficiency of the solid medicinal materials reaching the lower end of the crushing plate 212. When the motor 205 drives the first rotating rod 206 to reverse, the wound pull rope 35 will be released, and then the second spring 34 will reset, driving the pusher plate 33 back to its initial position. At this time, the shielding cloth 36 is in a folded state. After the medicinal liquid in the solid medicinal materials is crushed out, the controller 5 can activate the second electric telescopic rod 403 on the surface of the second fixed plate 402, and then the second electric telescopic rod 403 will drive the lifting plate 404 to descend.Then, the filling column 405 on the surface of the lifting plate 404 will detach from the filter hole 401 on the surface of the placement tank 7. The crushed medicine liquid will then leave the placement tank 7 through the filter hole 401. After the medicine liquid flows out of the placement tank 7, the second electric telescopic rod 403 will be activated to raise the lifting plate 404. Then, the filling column 405 will block the filter hole 401 on the surface of the placement plate 406 again, allowing the placement tank 7 to return to normal. The medicine liquid will then undergo secondary filtration through the filter plate 410. The medicine liquid will then leave the outer frame 1 through the outlet pipe 11. Finally, the third electric telescopic rod 407 on the placement plate 406 will be activated to move the moving block. 408 moves on the surface of filter plate 410, and then the scraper 411 and pointed column 412 on the third electric telescopic rod 407 scrape and disperse the solid medicine residue on the filter surface. Then, the second brush 409 cleans the solid medicine residue. After the moving plate reaches the inside of the collection box 10, the collection of the fixed medicine residue is completed. The solid medicine residue remaining inside the placement bucket 7 can be cleaned by adding water into the placement bucket 7 through the water inlet pipe 6. Then, the water pump 9 is started by the controller 5, and the water pump 9 and the water outlet pipe 8 pump water containing medicine residue into the collection box 10 to collect the medicine residue, thus completing the cleaning of the medicine residue inside the placement bucket 7.

Claims

1. A pharmaceutical apparatus for briracetam injection, comprising an outer frame (1) and a feed port (208) formed on the surface of an intermediate block (207), characterized in that: The outer frame (1) is provided with a controller (5) on its surface. A water inlet pipe (6) is provided on the side of the outer frame (1) near the controller (5). A placement bucket (7) is provided at the upper end of the outer frame (1). The outlet of the water inlet pipe (6) is located on the inner wall of the placement bucket (7). A water outlet pipe (8) is provided on the surface of the placement bucket (7). A collection box (10) is provided at the end of the outer frame (1) away from the controller (5). A water pump (9) is provided at the upper end of the collection box (10). One end of the water pump (9) is fixedly connected to the water outlet pipe (8). A compaction assembly (2) is provided inside the placement bucket (7). The component (2) crushes and separates the solid medicinal materials from the liquid medicine. The upper end of the intermediate block (207) is provided with a pushing component (3), which pushes the solid medicinal materials into the feed hole (208) quickly. The interior of the outer frame (1) is provided with a filter and cleaning component (4), which filters and separates the crushed solid medicinal materials and the liquid medicine. The crushing component (2) includes a bolt (201), which is threaded to the outer frame (1). The surface of the bolt (201) is threaded with a mounting plate (202), and the surface of the mounting plate (202) is fixedly connected to the bolt. A bracket (203) is attached, and a first electric telescopic rod (204) is fixedly connected to one end of the bracket (203) away from the mounting plate (202). A motor (205) is fixedly connected to the output end of the first electric telescopic rod (204), and a first rotating rod (206) is fixedly connected to the output end of the motor (205). An intermediate block (207) is fixedly connected to one end of the first rotating rod (206) away from the motor (205). A feed hole (208) is provided on the surface of the intermediate block (207), and the end of the intermediate block (207) away from the first rotating rod (206) is fixedly connected to... There are four first fixed plates (209), and the four first fixed plates (209) are in pairs. The interior of each pair of first fixed plates (209) is rotatably connected to a second rotating rod (210). The surface of the second rotating rod (210) is fixedly connected to a first connecting plate (211). The end of the first connecting plate (211) away from the second rotating rod (210) is fixedly connected to a rolling plate (212). The surface of the rolling plate (212) is inlaid with a number of balls (213). The ends of the two first connecting plates (211) that are close to each other are fixedly connected to a first spring (220).The end of the rolling plate (212) away from the first connecting plate (211) is fixedly connected to a plurality of first bristles (214), and a scraper (215) is fixedly connected in the middle of the plurality of first bristles (214). The filter cleaning assembly (4) includes a plurality of filter holes (401) opened at the bottom of the placement bucket (7). The output end of the second electric telescopic rod (403) is fixedly connected to a lifting plate (404), and a plurality of filling columns (405) are fixedly connected to the surface of the lifting plate (404). The size of the plurality of filling columns (405) is adapted to the size of the plurality of filter holes (401) on the surface of the placement bucket (7).

2. The pharmaceutical equipment for briracetam injection according to claim 1, characterized in that: A reinforcing plate (216) is fixedly connected to one side of the first connecting plate (211), and the end of the reinforcing plate (216) away from the first connecting plate (211) is fixedly connected to the rolling plate (212).

3. The pharmaceutical equipment for briracetam injection according to claim 2, characterized in that: The two ends of the second rotating rod (210) are fixedly connected to bearings (217), and the outer ring of the bearing (217) is fixedly connected to the first fixing plate (209).

4. The pharmaceutical equipment for briracetam injection according to claim 3, characterized in that: An operating block (218) is fixedly connected to the surface of the bolt (201). The surface of the operating block (218) has several anti-slip protrusions. A positioning block (219) is fixedly connected to the surface of the outer frame (1). The size of the positioning block (219) is adapted to the size of the mounting plate (202).

5. The pharmaceutical equipment for briracetam injection according to claim 4, characterized in that: The pushing component (3) includes a slide rail (31), which is fixedly connected to the middle block (207). A sliding block (32) is slidably connected inside the slide rail (31). A pushing plate (33) is fixedly connected to one side of the sliding block (32). A second spring (34) is fixedly connected to one end of the slide rail (31) near the sliding block (32). The end of the second spring (34) away from the slide rail (31) is fixedly connected to the sliding block (32). A pull rope (35) is fixedly connected to the surface of the sliding block (32). The end of the pull rope (35) away from the sliding block (32) is fixedly connected to the first rotating rod (206). A shielding cloth (36) is fixedly connected to one end of the slide rail (31) near the spring. One end of the shielding cloth (36) is fixedly connected to the sliding block (32).

6. The pharmaceutical equipment for briracetam injection according to claim 5, characterized in that: The outer frame (1) is fixedly connected to a second fixed plate (402), and a second electric telescopic rod (403) is fixedly connected to the surface of the second fixed plate (402). The outer frame (1) is fixedly connected to a placement plate (406) on the side near the controller (5). The surface of the placement plate (406) is fixedly connected to a third electric telescopic rod (407). The output end of the third electric telescopic rod (407) is fixedly connected to a moving block (408). The surface of the moving block (408) is fixedly connected to a second brush bristle (409). The outer frame (1) is fixedly connected to a filter plate (410). The filter plate (410) is located at the lower end of the second brush bristle (409) on the surface of the moving block (408). The end of the moving block (408) away from the second electric telescopic rod (403) is fixedly connected to a shovel (411). The surface of the shovel (411) is fixedly connected to a pointed post (412).

7. A pharmaceutical method using the pharmaceutical apparatus of claim 6 for briracetam injection, characterized in that, Includes the following steps: S1. When manufacturing bricetan injection, solid medicinal materials are boiled, and then the mounting plate (202) is placed on the surface of the outer frame (1). Then the bolt (201) is rotated to fix the mounting plate (202) to the surface of the outer frame (1). Then the first electric telescopic rod (204) on the bracket (203) is located at the center above the placement bucket (7). Then the first electric telescopic rod (204) is started by the controller (5), so that the output end of the first electric telescopic rod (204) drives the motor (205) to approach the placement bucket (7). Then the motor (205) drives the first rotating rod (206) and the middle block (207) to reach the inside of the placement bucket (7). At this time, the crushing plate (212) is also located inside the placement bucket (7). S2. Then, the solid medicinal materials that have been boiled are poured into the placement bucket (7). The solid medicinal materials then reach the bottom of the placement bucket (7) through the feed hole (208) on the surface of the middle block (207). At this time, the solid medicinal materials are located between the placement bucket (7) and the crushing plate (212). Then, the first electric telescopic rod (204) is activated by the controller (5) so that the ball bearings (213) on the surface of the crushing plate (212) come into contact with the solid medicinal materials. At this time, the second rotating rod (210) on the surface of the first fixed plate (209) will drive the first connecting plate (211) to rotate. The first spring (220) at the first connecting plate (211) will be stretched, and then the ball bearings (213) will crush the solid medicinal materials. The material is crushed, and then the motor (205) is started by the controller (5), so that the motor (205) drives the first rotating rod (206) to rotate. The rotation direction is forward for a period of time and reverse for a period of time. Then the first rotating rod (206) drives the middle block (207) to rotate. Then the crushing plate (212) drives the ball (213) to rotate. Then the output end of the first electric telescopic rod (204) reciprocates continuously. At this time, the two crushing plates (212) will continuously approach and move away from each other and will continuously rotate. Then the ball (213) on the crushing plate (212) crushes the solid medicinal material at the bottom of the container (7) from multiple angles, so that the liquid in the solid medicinal material is crushed out. S3. When some solid medicinal materials do not enter the feed hole (208) at the upper end of the middle block (207), when the first rotating rod (206) rotates, the pull rope (35) will be wound up by the first rotating rod (206), and then the sliding block (32) will slide inside the slide rail (31), and then drive the push plate (33) to approach the feed hole (208) on the surface of the middle block (207). At this time, the second spring (34) will be stretched, and the shielding cloth (36) will also be stretched, so that the shielding cloth (36) is always against the second spring (34). To prevent solid medicinal materials from getting stuck in the gap of the second spring (34), the pusher plate (33) drives some of the solid medicinal materials at the upper end of the middle block (207) into the feed hole (208), thereby improving the efficiency of the solid medicinal materials reaching the lower end of the crushing plate (212). When the motor (205) drives the first rotating rod (206) to reverse, the wound pull rope (35) will be released, and then the second spring (34) will reset, driving the pusher plate (33) back to the initial position. At this time, the shielding cloth (36) is in a folded state. S4. After the liquid medicine is crushed out of the solid medicinal material, the second electric telescopic rod (403) on the surface of the second fixed plate (402) is activated by the controller (5). Then, the second electric telescopic rod (403) drives the lifting plate (404) to descend. Then, the filling column (405) on the surface of the lifting plate (404) will detach from the filter hole (401) on the surface of the placement bucket (7). Then, the crushed liquid medicine leaves the placement bucket (7) through the filter hole (401). After the liquid medicine flows out of the placement bucket (7), the second electric telescopic rod (403) is activated again to raise the lifting plate (404). Then, the filling column (405) blocks the filter hole (405) on the surface of the placement plate (406) again. 01), restore the placement bucket (7) to normal state, then the medicine liquid is filtered again through the filter plate (410) for a second time, and then the medicine liquid leaves the outer frame (1) through the outlet pipe (11). Then the third electric telescopic rod (407) on the placement plate (406) is activated, so that the third electric telescopic rod (407) drives the moving block (408) to move on the surface of the filter plate (410). Then the shovel (411) and the pointed column (412) on the third electric telescopic rod (407) shovel and disperse the solid medicine residue on the filter surface. Then the second brush (409) cleans the solid medicine residue. Then the collection of the fixed medicine residue is completed after the moving plate reaches the inside of the collection box (10). S5. The solid medicine residue inside the placement bucket (7) is added to the placement bucket (7) through the water inlet pipe (6), and then the medicine residue is cleaned. Then the water pump (9) is started through the controller (5), and then the water pump (9) and the water outlet pipe (8) pump the water containing the medicine residue into the collection box (10) to collect the medicine residue, and then the cleaning of the medicine residue inside the placement bucket (7) is completed.

Images