A medicinal health-care composition for improving hair loss and preparation method thereof

Abstract

The present invention belongs to the field of preparation of medicinal health-care compositions, and in particular to a medicinal health-care composition for improving hair loss and a preparation method thereof. Among them, the natural Anuka apple extract and deep-sea fish collagen peptide powder in the raw materials promote the growth of hair by providing the amino acids required by the human body and inducing the production of keratin. After taking the medicine, the vertical elongation rate of hair of patients with hair loss can reach 80.2%, and it has the effects of anti-inflammatory, moisturizing and repairing the scalp; D-biotin can promote the synthesis of amino acids, maintain the normal function of hair follicles and prevent gray hair, and inactive brewer's yeast is rich in high-quality protein, B vitamins, and dietary fiber, which can be used as a supplement of D-biotin. The two work synergistically, which can not only promote healthy hair growth, but also regulate intestinal health; the medicinal health-care composition for improving hair loss is a pill, which has a long duration of efficacy, slow release, little irritation to the stomach, and no side effects.

Description

Technical Field

[0001] The invention belongs to the field of preparation of medicinal health-care compositions, and specifically relates to a medicinal health-care composition for improving hair loss and a preparation method thereof. Background Art

[0002] Endocrine disorders caused by irregular work and rest, fungal infections, greasy diet, and excessive mental stress have made hair loss a common symptom for modern people. In recent years, people have begun to pay attention to their own hair loss problems. A large number of shampoos, drugs, and nutritional supplements have appeared on the market to improve hair loss. These products reduce hair loss by stimulating the hair follicles on the scalp, inhibiting the synthesis of male hormones, accelerating the blood circulation of the scalp, and changing the endocrine environment of the human body. As the "protective membrane" that wraps the brain skull, scalp health is very important. Damage to the scalp will lead to dry and frizzy hair, scalp inflammation and acne, and a significant increase in the amount of hair loss.

[0003] At present, the existing medicinal health-care compositions for improving hair loss and the preparation technology thereof have the following problems: 1. The existing medicinal health-care compositions for improving hair loss used for treating hair loss excessively inhibit the secretion of male hormones, leading to the generation of depression and irritability, and destroying the normal reproductive function of the human body; 2. The product can seriously irritate the gastric mucosa, affect the gastrointestinal function, and cause abdominal pain, loss of appetite, nausea, and contain central nervous system inhibitory ingredients, making people sleepy; 3. By inhibiting the proliferation of scalp cells, hair loss is reduced, which can increase dandruff, make the hair dry, frizzy, and easy to break, cause scalp inflammation, and cause more serious hair loss; 4. Long-term use can stimulate local hair follicles, causing insufficient blood supply around the hair follicles, causing hair follicle atrophy; 5. After taking it, it affects the hormone level in the body, leading to endocrine disorders; 6. The drug effect lasts for a short time, the content of effective ingredients is low, and long-term and large-scale use can damage the liver and make the scalp dependent. When the drug is stopped or the dosage is reduced, the hair cannot grow normally, which is manifested as the hair cannot become smooth and easy to fall off. Summary of the invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the present invention provides a medicinal health care composition for improving hair loss and a preparation method thereof. In order to solve the problems of inhibiting the secretion of human male hormones, destroying reproductive function, producing irritable and depressed emotions, loss of appetite, nausea and vomiting, liver damage, hair follicle atrophy, endocrine disorders, and easy dependence, the present invention proposes to add Anuka apple extract and deep-sea fish collagen peptide powder. Anuka apples are rich in apple polyphenols. The proanthocyanidin B2 in apple polyphenols has anti-inflammatory ability and can also induce the production of keratin, promote hair growth, and increase the regeneration potential of the scalp. In addition, Anuka apple extracts also contain a large amount of ursolic acid, which has multiple effects of sedation, anti-inflammatory, and antibacterial. The composition structure of fish collagen is most similar to that of the human body, with the highest absorption rate. It is rich in glycine, proline, Amino acids such as hydroxyproline can provide sufficient protein to maintain the nutrition of hair and make hair soft and shiny; at the same time, the inactive brewer's yeast powder is used in combination with D-biotin, which is a necessary nutrient for hair growth and can promote the synthesis of amino acids in the human body, stimulate the formation of protein, and maintain normal hair follicle function. The inactive brewer's yeast is rich in nutrients and is a high-quality protein source. It can provide the human body with the required amino acids and can also be used as a supplement of D-biotin. The inactive brewer's yeast powder and D-biotin act synergistically, which can not only promote hair growth but also regulate intestinal health; in addition, the medicinal health-care composition for improving hair loss of the present invention is a pill, which has a long drug efficacy, is released slowly, has less irritation to the stomach, has no side effects, and does not require heating during the preparation process, so the effective ingredients therein can be better retained.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is as follows: the present invention proposes a medicinal health-care composition for improving hair loss, comprising the following components in parts by weight:

[0006] 100-120 parts of Anuka apple extract, 24-50 parts of inactive brewer's yeast powder, 10-20 parts of deep-sea fish collagen peptide powder, 5-10 parts of D-biotin, 3-6 parts of edible selenium powder, 0.5-1 parts of edible zinc powder, and 8-12 parts of sterile ultrapure water.

[0007] Preferably, the preparation method of the Anuka apple extract specifically comprises the following steps:

[0008] S1. Wash fresh Anuka apples with sterile ultrapure water. After washing, put the fresh Anuka apples into an automatic cutting machine to cut them evenly to obtain Anuka apple raw materials;

[0009] S2, placing the Anuka apple raw material prepared in step S1 into a sterile pulping machine, and performing sufficient low-temperature pulping to obtain Anuka apple puree;

[0010] S3, adding pectinase to the Anuka apple puree prepared in step S2, and performing sufficient enzymolysis to obtain an Anuka apple enzymolysis solution;

[0011] S4, pouring the Anuka apple enzymatic hydrolyzate prepared in step S3 into an ultrasonic extractor, adding a 60% ethanol solution, and performing ultrasonic extraction to obtain an Anuka apple ultrasonic extract;

[0012] S5, pouring the Anuka apple ultrasonic extract prepared in step S4 into an industrial centrifuge, and filtering and removing residues using a filter screen after centrifugation to obtain an Anuka apple filtrate;

[0013] S6. Place the Anuka apple filtrate obtained in step S5 in a vacuum concentrator for vacuum concentration to obtain an Anuka apple extract.

[0014] Furthermore, in S1, the weight of the fresh Anuka apples is 300-500 parts; the power of the automatic dicing machine is 0.75-2.25 kW, the dicing time is 30-45 min, the dicing temperature is 18-22°C, and the dicing size and shape are 10-15 mm cubes.

[0015] Further, in S2, the power of the aseptic refiner is 16-20 kW, the refining temperature is 15-20°C, the refining rate is 1000-1200 r / min, and the refining time is 50-75 min.

[0016] Furthermore, in S3, the weight ratio of the pectinase to the Anuka apple puree is 1:100-150, the enzymolysis temperature is 25-28°C, and the enzymolysis time is 6-8 h.

[0017] Further, in S4, the power of the ultrasonic extractor is 1-1.8 kW, the extraction temperature is 35-45°C, the extraction time is 40-60 min, and the extraction frequency is 25-50 kHz; the weight ratio of the ethanol solution to the Anuka apple puree is 1:18-24.

[0018] Furthermore, in S5, the centrifugal speed of the industrial centrifuge is 1000-1100 r / min, the centrifugal time is 25-40 min, and the centrifugal temperature is 0-5°C; and the filter screen is a 100-140 mesh filter screen.

[0019] Further, in S6, the power of the vacuum decompression concentrator is 5.2-7.8 kW, the vacuum degree is -0.08 MPa, the concentration temperature is 25-35°C, the concentration rate is 500-1000 L / h, the concentration time is 10-15 min, and the concentration multiple is 12-16 times.

[0020] The present invention also provides a method for preparing a medicinal health-care composition for improving hair loss, which specifically comprises the following steps:

[0021] Step 1, weighing Anuka apple extract, inactive brewer's yeast powder, deep-sea fish collagen peptide powder, D-biotin, edible selenium powder, edible zinc powder, and sterile ultrapure water by weight, putting them into a sterile stirring tank, stirring, and obtaining a medicinal health care combination mixture;

[0022] Step 2: putting the medicinal health care combination mixture prepared in step 1 into a fully automatic pill-making machine to make pills to obtain a moisturizing medicinal health care composition for improving hair loss;

[0023] Step 3: Put the moist medicinal health-care composition for improving hair loss prepared in step 2 into a dryer and dry it at low temperature to obtain the medicinal health-care composition for improving hair loss.

[0024] Preferably, in step 1, the stirring speed of the sterile stirring tank is 100-130 r / min, the stirring time is 20-30 min, and the stirring temperature is 23-26°C.

[0025] Preferably, in step 2, the pill making power of the fully automatic pill making machine is 1.5-1.8 kW, the pill making temperature is 25-30° C., the pill making time is 40-60 min, and the pill making diameter is 15-30 mm.

[0026] Preferably, in step three, the low-temperature drying temperature of the dryer is 35-45° C., and the drying time is 2.5-4 h.

[0027] The beneficial effects achieved by the present invention include:

[0028] The present invention proposes to add Anuka apple extract, deep-sea fish collagen peptide powder, edible zinc powder and edible selenium powder. Anuka apple is rich in apple polyphenols. Proanthocyanidin B2 in apple polyphenols has extraordinary antioxidant and anti-inflammatory capabilities, and can induce the production of keratin by stimulating the proliferation of keratinocytes, inhibit protein kinase C isoenzymes and regulate transforming growth factor β and other aspects, thereby promoting hair growth, improving basal keratinocytes and increasing the regeneration potential of the scalp. In addition, Anuka apple extract also contains a large amount of ursolic acid, which has multiple effects of calming, anti-inflammatory, antibacterial and repairing liver function. The composition structure of fish collagen is most similar to that of the human body, with the highest absorption rate. It is rich in amino acids such as glycine, proline and hydroxyproline required by the human body, and can provide sufficient protein to maintain the nutrition of the hair, making the hair soft and shiny. It also has the effect of moisturizing the scalp, effectively maintaining the elasticity of the scalp skin and repairing the damaged scalp. Zinc and selenium elements can inhibit the scalp The oil secretion of the sebaceous glands of the skin accelerates the synthesis of hair keratin and promotes hair growth; at the same time, the inactive brewer's yeast powder is used in combination with D-biotin, which is a necessary nutrient for hair growth and can promote the synthesis of amino acids in the human body, stimulate the formation of protein, maintain normal hair follicle function and prevent gray hair. The inactive brewer's yeast is rich in nutrients and is a high-quality protein source. It can provide the human body with the required amino acids. The dietary fiber contained can promote intestinal peristalsis. The inactive brewer's yeast powder contains vitamin B group and can be used as a supplement of D-biotin. The inactive yeast powder and D-biotin work synergistically, which can not only promote the healthy growth of hair, but also regulate intestinal health. In addition, the medicinal health-care composition for improving hair loss of the present invention is a pill, which has a long drug effect maintenance time, is slowly released, has less stimulation to the stomach, has no side effects, and does not require high-temperature heating during the preparation process, so that the effective active ingredients in each component can be better retained. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the present invention or the technical solutions in the prior art, the following will be described in a clear and understandable manner in conjunction with the accompanying drawings. Obviously, the drawings described below are only for the present invention, and for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0030] Figure 1 This is the molecular formula diagram of proanthocyanidin B2;

[0031] Figure 2 This is the molecular formula diagram of ursolic acid;

[0032] Figure 3 This is the molecular formula diagram of D-biotin;

[0033] Figure 4 This is the molecular formula diagram of fish collagen peptide;

[0034] Figure 5 This is the result graph of vertical elongation of hair;

[0035] Figure 6 This is the hair density result map;

[0036] Figure 7 This is the effect picture of patient A before and after taking the medicine;

[0037] Figure 8 These are the effects before and after treatment for patient B. DETAILED DESCRIPTION

[0038] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0039] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0040] The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials and test strains used in the following examples are purchased from commercial channels unless otherwise specified.

[0041] Example 1: This example provides a medicinal health-care composition for improving hair loss and a preparation method thereof. The medicinal health-care composition for improving hair loss comprises the following components in parts by weight:

[0042] 100 parts of Anuka apple extract, 24 parts of inactive brewer's yeast powder, 10 parts of deep-sea fish collagen peptide powder, 5 parts of D-biotin, 3 parts of edible selenium powder, 0.5 parts of edible zinc powder, and 8 parts of sterile ultrapure water.

[0043] The preparation method of the Anuka apple extract specifically comprises the following steps:

[0044] S1. Wash 300 parts by weight of fresh Anuka apples with sterile ultrapure water. After washing, put the fresh Anuka apples into an automatic cutting machine. The power of the cutting machine is 0.75 kW, the cutting time is 30 min, the cutting temperature is 18° C., and the cutting size and shape are 10 mm cubes. Cut the pieces uniformly to obtain Anuka apple raw materials.

[0045] S2, placing the Anuka apple raw material prepared in step S1 into a sterile pulping machine, wherein the power of the sterile pulping machine is 16 kW, the pulping temperature is 15°C, the pulping rate is 1000 r / min, and the pulping time is 50 min. After sufficient low-temperature pulping, Anuka apple pulp is obtained;

[0046] S3, adding pectinase to the Anuka apple puree prepared in step S2, the weight ratio of pectinase to Anuka apple puree is 1:100, the enzymolysis temperature is 25°C, and the enzymolysis time is 6 hours. Fully enzymolyze to obtain Anuka apple enzymolyzate;

[0047] S4, pouring the Anuka apple enzymatic hydrolyzate prepared in step S3 into an ultrasonic extractor, the ultrasonic extractor power is 1 kW, the extraction temperature is 35°C, the extraction time is 40 min, the extraction frequency is 25 kHz, adding a 60% ethanol solution, the weight ratio of the ethanol solution to the Anuka apple puree is 1:18, and performing ultrasonic extraction to obtain an Anuka apple ultrasonic extract;

[0048] S5, pouring the Anuka apple ultrasonic extract prepared in step S4 into an industrial centrifuge, centrifuging at a speed of 1000 r / min, centrifuging for 25 min, and centrifuging at a temperature of 0° C. After centrifugation, filtering with a 100-mesh filter screen to remove residues, to obtain an Anuka apple filtrate;

[0049] S6. The Anuka apple filtrate prepared in step S5 is placed in a vacuum decompression concentrator with a power of 5.2 kW, a vacuum degree of -0.08 MPa, a concentration temperature of 25°C, a concentration rate of 500 L / h, a concentration time of 10 min, and a concentration multiple of 12 times, and is concentrated under reduced pressure to obtain an Anuka apple extract.

[0050] This embodiment also provides a method for preparing a medicinal health-care composition for improving hair loss, which specifically comprises the following steps:

[0051] Step 1, weighing Anuka apple extract, inactive brewer's yeast powder, deep-sea fish collagen peptide powder, D-biotin, edible selenium powder, edible zinc powder, and sterile ultrapure water by weight, putting them into a sterile stirring tank, stirring at a speed of 100 r / min, a stirring time of 20 min, and a stirring temperature of 23° C. to obtain a medicinal health care combination mixture;

[0052] Step 2: Put the medicinal health care combination mixture prepared in step 1 into a fully automatic pill-making machine to make pills, with a pill-making power of 1.5 kW, a pill-making temperature of 25° C., a pill-making time of 40 min, and a pill-making diameter of 15 mm to obtain a moisturizing medicinal health care composition for improving hair loss;

[0053] Step 3: put the moist medicinal health-care composition for improving hair loss prepared in step 2 into a dryer and dry it at low temperature. The low-temperature drying temperature is 35° C. and the drying time is 2.5 h to obtain a medicinal health-care composition for improving hair loss.

[0054] Example 2: This example provides a medicinal health-care composition for improving hair loss and a preparation method thereof. The medicinal health-care composition for improving hair loss comprises the following components in parts by weight:

[0055] 110 parts of Anuka apple extract, 38 parts of inactive brewer's yeast powder, 15 parts of deep-sea fish collagen peptide powder, 8 parts of D-biotin, 4 parts of edible selenium powder, 0.7 parts of edible zinc powder, and 10 parts of sterile ultrapure water.

[0056] The preparation method of the Anuka apple extract specifically comprises the following steps:

[0057] S1. Wash 400 parts by weight of fresh Anuka apples with sterile ultrapure water. After washing, put the fresh Anuka apples into an automatic cutting machine. The power of the cutting machine is 1.5 kW, the cutting time is 40 min, the cutting temperature is 20° C., and the cutting size and shape are 13 mm cubes. Cut the pieces uniformly to obtain Anuka apple raw materials.

[0058] S2. Put the Anuka apple raw material prepared in step S1 into a sterile pulping machine, the power of the sterile pulping machine is 18 kW, the pulping temperature is 17°C, the pulping rate is 1100 r / min, and the pulping time is 60 min. After sufficient low-temperature pulping, the Anuka apple puree is obtained;

[0059] S3, adding pectinase to the Anuka apple puree prepared in step S2, the weight ratio of pectinase to Anuka apple puree is 1:125, the enzymolysis temperature is 26°C, and the enzymolysis time is 7 hours. Fully enzymolyze to obtain Anuka apple enzymolyzate;

[0060] S4, pouring the Anuka apple enzymatic hydrolyzate prepared in step S3 into an ultrasonic extractor with a power of 1.5 kW, an extraction temperature of 40°C, an extraction time of 50 min, and an extraction frequency of 35 kHz, adding a 60% ethanol solution, wherein the weight ratio of the ethanol solution to the Anuka apple puree is 1:20, and performing ultrasonic extraction to obtain an Anuka apple ultrasonic extract;

[0061] S5, pouring the Anuka apple ultrasonic extract prepared in step S4 into an industrial centrifuge, centrifuging at a speed of 1000 r / min, centrifuging for 30 min, and centrifuging at a temperature of 2° C. After centrifugation, filtering with a 120-mesh filter screen to remove residues, to obtain an Anuka apple filtrate;

[0062] S6. The Anuka apple filtrate prepared in step S5 is placed in a vacuum decompression concentrator with a power of 6.5 kW, a vacuum degree of -0.08 MPa, a concentration temperature of 30°C, a concentration rate of 800 L / h, a concentration time of 13 min, and a concentration multiple of 14 times, and is concentrated under reduced pressure to obtain an Anuka apple extract.

[0063] This embodiment also provides a method for preparing a medicinal health-care composition for improving hair loss, which specifically comprises the following steps:

[0064] Step 1, weighing Anuka apple extract, inactive brewer's yeast powder, deep-sea fish collagen peptide powder, D-biotin, edible selenium powder, edible zinc powder, and sterile ultrapure water by weight, putting them into a sterile stirring tank, stirring at a speed of 100 r / min, a stirring time of 20 min, and a stirring temperature of 23° C. to obtain a medicinal health care combination mixture;

[0065] Step 2: Put the medicinal health care combination mixture prepared in step 1 into a fully automatic pill-making machine to make pills, with a pill-making power of 1.5 kW, a pill-making temperature of 25° C., a pill-making time of 40 min, and a pill-making diameter of 15 mm to obtain a moisturizing medicinal health care composition for improving hair loss;

[0066] Step 3: put the moist medicinal health-care composition for improving hair loss prepared in step 2 into a dryer and dry it at low temperature. The low-temperature drying temperature is 35° C. and the drying time is 2.5 h to obtain a medicinal health-care composition for improving hair loss.

[0067] Example 3: This example provides a medicinal health-care composition for improving hair loss and a preparation method thereof. The medicinal health-care composition for improving hair loss comprises the following components in parts by weight:

[0068] 120 parts of Anuka apple extract, 50 parts of inactive brewer's yeast powder, 20 parts of deep-sea fish collagen peptide powder, 10 parts of D-biotin, 6 parts of edible selenium powder, 1 part of edible zinc powder, and 12 parts of sterile ultrapure water.

[0069] The preparation method of the Anuka apple extract specifically comprises the following steps:

[0070] S1. Wash 500 parts by weight of fresh Anuka apples with sterile ultrapure water. After washing, put the fresh Anuka apples into an automatic cutting machine. The power of the cutting machine is 2.25 kW, the cutting time is 45 min, the cutting temperature is 22° C., and the cutting size and shape are 15 mm cubes. Cut the pieces uniformly to obtain Anuka apple raw materials.

[0071] S2, placing the Anuka apple raw material prepared in step S1 into a sterile pulping machine, wherein the power of the sterile pulping machine is 20 kW, the pulping temperature is 20°C, the pulping rate is 1200 r / min, and the pulping time is 75 min. After sufficient low-temperature pulping, Anuka apple pulp is obtained;

[0072] S3, adding pectinase to the Anuka apple puree prepared in step S2, the weight ratio of pectinase to Anuka apple puree is 1:150, the enzymolysis temperature is 28°C, and the enzymolysis time is 8 hours. Fully enzymolyze to obtain Anuka apple enzymolyzate;

[0073] S4, pouring the Anuka apple enzymatic hydrolyzate prepared in step S3 into an ultrasonic extractor with a power of 1.8 kW, an extraction temperature of 45°C, an extraction time of 60 min, and an extraction frequency of 50 kHz, adding a 60% ethanol solution, wherein the weight ratio of the ethanol solution to the Anuka apple puree is 1:24, and performing ultrasonic extraction to obtain an Anuka apple ultrasonic extract;

[0074] S5, pouring the Anuka apple ultrasonic extract prepared in step S4 into an industrial centrifuge, centrifuging at a speed of 1100 r / min, centrifuging for 40 min, and centrifuging at a temperature of 5° C. After centrifugation, filtering with a 140-mesh filter screen to remove residues, to obtain an Anuka apple filtrate;

[0075] S6. The Anuka apple filtrate prepared in step S5 is placed in a vacuum decompression concentrator with a power of 7.8 kW, a vacuum degree of -0.08 MPa, a concentration temperature of 35°C, a concentration rate of 1000 L / h, a concentration time of 15 min, and a concentration multiple of 16 times, and is concentrated under reduced pressure to obtain an Anuka apple extract.

[0076] This embodiment also provides a method for preparing a medicinal health-care composition for improving hair loss, which specifically comprises the following steps:

[0077] Step 1, weighing Anuka apple extract, inactive brewer's yeast powder, deep-sea fish collagen peptide powder, D-biotin, edible selenium powder, edible zinc powder, and sterile ultrapure water by weight, putting them into a sterile stirring tank, stirring at a speed of 130 r / min, a stirring time of 30 min, and a stirring temperature of 26° C. to obtain a medicinal health care combination mixture;

[0078] Step 2: Put the medicinal health care combination mixture prepared in step 1 into a fully automatic pill-making machine to make pills, with a pill-making power of 1.8 kW, a pill-making temperature of 30° C., a pill-making time of 60 min, and a pill-making diameter of 30 mm to obtain a moisturizing medicinal health care composition for improving hair loss;

[0079] Step 3: put the moist medicinal health-care composition for improving hair loss prepared in step 2 into a dryer and dry it at low temperature. The low-temperature drying temperature is 45° C. and the drying time is 4 h to obtain a medicinal health-care composition for improving hair loss.

[0080] Comparative Example 1: This comparative example provides a medicinal health-care composition for improving hair loss and a preparation method. The only difference from Example 1 is that the prepared medicinal health-care composition for improving hair loss does not contain Anuka apple extract.

[0081] Comparative Example 2: This comparative example provides a medicinal health-care composition for improving hair loss and a preparation method. The only difference from Example 1 is that the prepared medicinal health-care composition for improving hair loss does not contain inactive brewer's yeast powder.

[0082] Comparative Example 3: This comparative example provides a method for preparing a medicinal health-care composition for improving hair loss, which specifically comprises the following steps:

[0083] Step 1, weighing Anuka apple extract, inactive brewer's yeast powder, deep-sea fish collagen peptide powder, D-biotin, edible selenium powder, and edible zinc powder by weight, putting them into a sterile stirring tank, stirring at a speed of 100 r / min, a stirring time of 20 min, and a stirring temperature of 23° C. to obtain a medicinal health care combination mixture;

[0084] Step 2: Put the medicinal health care combination mixture prepared in step 1 into a powdering machine for powdering, with a powdering power of 1.5 kW, a powdering temperature of 25° C., a powdering time of 40 min, and a powdering diameter of 15 mm to obtain a moisturizing medicinal health care composition for improving hair loss;

[0085] Step 3, filtering the moisturizing hair loss improving medicinal health care composition prepared in step 2 through a filter screen to obtain a moisturizing hair loss improving medicinal health care composition powder;

[0086] Step 4: put the moist powder of the medicinal health-care composition for improving hair loss prepared in step 3 into a dryer and dry it at low temperature. The low-temperature drying temperature is 35° C. and the drying time is 2.5 h to obtain a medicinal health-care composition for improving hair loss.

[0087] Experimental Example 1: Test for measuring the overall condition of hair

[0088] The medicinal health-care composition for improving hair loss prepared in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3 was used for an experiment, which specifically included the following experimental steps:

[0089] (1) 70 patients with hair loss were randomly selected and divided into 7 groups of 10;

[0090] (2) 30 g of the medicinal health-care composition for improving hair loss prepared in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3 were respectively provided to different groups of hair loss patients every day, and the group of hair loss patients taking the ordinary medicinal health-care composition for improving hair loss was the CK control group, and the patients took the composition for 60 days;

[0091] (3) After taking the medicine for 60 days, the overall condition of the hair of 70 patients with hair loss was observed and recorded. The results are shown in Table 1.

[0092] Table 1. Overall hair condition of patients with hair loss

[0093]

[0094] Result analysis: As shown in Table 1, after taking the medicinal health-care composition for improving hair loss prepared by the CK control group, Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3, the hair of the hair loss patients in the Example 1-3 group and the Comparative Example 3 group was in good condition, while the hair of the hair loss patients in the CK control group and the Comparative Example 1-2 group was dry and dull, and the scalp was tight, inflamed, and had dandruff. The proanthocyanidin B2 in the Anuka apple extract in the medicinal health-care composition for improving hair loss obtained in the present invention has extraordinary anti-inflammatory ability, improves basal keratinocytes, and increases the regeneration potential of the scalp. In addition, ursolic acid has extremely strong sedative, anti-inflammatory, and antibacterial effects, which effectively protects the health of hair follicles.

[0095] Experimental Example 2: Measurement of hair vertical elongation and hair density

[0096] The medicinal health-care composition for improving hair loss prepared in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3 was used for an experiment, which specifically included the following experimental steps:

[0097] (1) 70 patients with hair loss were randomly selected and divided into 7 groups of 10;

[0098] (2) 30 g of the medicinal health-care composition for improving hair loss prepared in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3 were respectively provided to different groups of hair loss patients every day, and the group of hair loss patients taking the ordinary medicinal health-care composition for improving hair loss was the CK control group, and the patients took the composition for 60 days;

[0099] (3) After taking the medicine for 60 days, the hair elongation rate of each group of patients with hair loss was calculated, and the final result was averaged;

[0100] (4) After taking the medicine for 60 days, the total number of hair roots in 100 random hair follicles of each group of hair loss patients was recorded, and the final result was averaged.

[0101] Calculation formula: hair elongation (%) = mb-ma / ma × 100%;

[0102] In the formula: ma——hair length of the hair loss patient before taking the medicine, cm;

[0103] mb——hair length of patients with hair loss after taking the medicine, cm.

[0104] Result analysis: Figure 5 The results of the vertical elongation rate of hair of patients after taking the medicinal health-care composition for improving hair loss described in Examples 1-3 and Comparative Examples 1-3 of the present invention are shown in the figure. As shown in the figure, the hair elongation rates of hair loss patients in the Example 1-3 group and the Comparative Example 1-3 group are higher than that in the control group. The hair elongation rates of the Example 1-3 group are 78.9%, 80.2% and 79.8%, respectively, which are 1.42 times the hair elongation rates of the Comparative Example 1-2 group; Figure 6 The hair density result graph of the patients after taking the medicinal health care composition for improving hair loss described in Examples 1-3 and Comparative Examples 1-3 of the present invention is recorded, and the number of hair roots per 100 hair follicles of the patients with hair loss is recorded. As shown in the figure, the number of hair roots per 100 hair follicles of the patients with hair loss in the Example 1-3 group is 368, 370, and 371, which is 1.4 times that of the Comparative Example 1-2 group; Figure 7-8 The figures are the effect diagrams of patient A and patient B in group 1 of Example 1 before and after taking the medicine, which show that the Anuka apple extract in the medicinal health-care composition for improving hair loss of the present invention can induce the production of keratin by stimulating the proliferation of keratinocytes, thereby promoting the growth of hair. The inactive brewer's yeast is rich in nutrients, is a high-quality protein source, can provide the human body with the required amino acids, significantly promotes the normal growth of hair, and reduces hair loss.

[0105] Experimental Example 3: Determination of side effects after taking the drug

[0106] The medicinal health-care composition for improving hair loss prepared in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3 was used for an experiment, which specifically included the following experimental steps:

[0107] (1) 70 patients with hair loss were randomly selected and divided into 7 groups of 10;

[0108] (2) 30 g of the medicinal health-care composition for improving hair loss prepared in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3 were respectively provided to different groups of hair loss patients every day, and the group of hair loss patients taking the ordinary medicinal health-care composition for improving hair loss was the CK control group;

[0109] (3) The side effects of the hair loss patients in each group after taking the medicine were recorded during the 10-day period. The results are shown in Table 2.

[0110] Table 2. Side effects after taking the medicine

[0111]

[0112] Result analysis: As shown in Table 2, during the 10-day process of taking the medicinal health-care composition for improving hair loss prepared by the CK control group, Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3, the hair loss patients in Example 1-3 groups and Comparative Example 1 group did not experience any side effects, while the hair loss patients in Comparative Example 1-2 groups experienced mild nausea and vomiting symptoms and were in a general mood. The inactive brewer's yeast in the medicinal health-care composition for improving hair loss of the present invention is not only rich in nutrition, but also a high-quality protein source, which can provide the human body with the required amino acids, and the dietary fiber contained therein can promote intestinal peristalsis and regulate intestinal health. In addition, the medicinal health-care composition for improving hair loss of the present invention is a pill, which has a long drug efficacy and is released slowly, causing relatively mild side effects, less irritation to the stomach, and no side effects.

[0113] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0114] The present invention and its implementation methods are described above, which is not restrictive. The drawings are only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. A medicinal health-care composition for improving hair loss, characterized in that: The medicinal health-care composition for improving hair loss is composed of the following ingredients: 100-120 parts of Anuka apple extract, 24-50 parts of inactive brewer's yeast powder, 10-20 parts of deep-sea fish collagen peptide powder, 5-10 parts of D-biotin, 3-6 parts of edible selenium powder, 0.5-1 parts of edible zinc powder, 8-12 parts of sterile ultrapure water; The preparation method of the Anuka apple extract specifically comprises the following steps: S1. Wash fresh Anuka apples with sterile ultrapure water. After washing, put the fresh Anuka apples into an automatic cutting machine to cut them evenly to obtain Anuka apple raw materials; S2, placing the Anuka apple raw material prepared in step S1 into a sterile pulping machine, and performing sufficient low-temperature pulping to obtain Anuka apple puree; S3, adding pectinase to the Anuka apple puree prepared in step S2, and performing sufficient enzymolysis to obtain an Anuka apple enzymolysis solution; S4, pouring the Anuka apple enzymatic hydrolyzate prepared in step S3 into an ultrasonic extractor, adding a 60% ethanol solution, and performing ultrasonic extraction to obtain an Anuka apple ultrasonic extract; S5, pouring the Anuka apple ultrasonic extract prepared in step S4 into an industrial centrifuge, and filtering and removing residues using a filter screen after centrifugation to obtain an Anuka apple filtrate; S6, placing the Anuka apple filtrate prepared in step S5 in a vacuum concentrator for vacuum concentration to obtain an Anuka apple extract; The weight of the fresh Anuka apples is 300-500 parts; the power of the automatic dicing machine is 0.75-2.25 kW, the dicing time is 30-45 min, the dicing temperature is 18-22° C., and the dicing size and shape are 10-15 mm cubes; The power of the aseptic pulping machine is 16-20 kW, the pulping temperature is 15-20°C, the pulping rate is 1000-1200 r / min, and the pulping time is 50-75 min; The weight ratio of the pectinase to the Anuka apple puree is 1:100-150, the enzymolysis temperature is 25-28°C, and the enzymolysis time is 6-8 h; The power of the ultrasonic extractor is 1-1.8 kW, the extraction temperature is 35-45°C, the extraction time is 40-60 min, and the extraction frequency is 25-50 kHz; the weight ratio of the ethanol solution to the Anuka apple puree is 1:18-24; The industrial centrifuge has a centrifugal speed of 1000-1100 r / min, a centrifugal time of 25-40 min, and a centrifugal temperature of 0-5°C; the filter screen is a 100-140 mesh filter screen; The vacuum decompression concentrator has a power of 5.2-7.8 kW, a vacuum degree of -0.08 MPa, a concentration temperature of 25-35°C, a concentration rate of 500-1000 L / h, a concentration time of 10-15 min, and a concentration multiple of 12-16 times; The method for preparing the medicinal health-care composition for improving hair loss specifically comprises the following steps: Step 1, weighing Anuka apple extract, inactive brewer's yeast powder, deep-sea fish collagen peptide powder, D-biotin, edible selenium powder, edible zinc powder, and sterile ultrapure water by weight, putting them into a sterile stirring tank, stirring, and obtaining a medicinal health care combination mixture; Step 2: putting the medicinal health care combination mixture prepared in step 1 into a fully automatic pill-making machine to make pills to obtain a moisturizing medicinal health care composition for improving hair loss; Step 3: Put the moist medicinal health-care composition for improving hair loss prepared in step 2 into a dryer and dry it at low temperature to obtain the medicinal health-care composition for improving hair loss.

2. The medicinal health-care composition for improving hair loss according to claim 1, characterized in that: In step 1, the stirring speed of the sterile stirring tank is 100-130 r / min, the stirring time is 20-30 min, and the stirring temperature is 23-26°C.

3. The medicinal health-care composition for improving hair loss according to claim 2, characterized in that: In step 2, the pill making power of the fully automatic pill making machine is 1.5-1.8 kW, the pill making temperature is 25-30° C., the pill making time is 40-60 min, and the pill making diameter is 15-30 mm.

4. The medicinal health-care composition for improving hair loss according to claim 3, characterized in that: In step three, the low-temperature drying temperature of the dryer is 35-45° C., and the drying time is 2.5-4 h.

Images