Anti-adhesion, repair-promoting braided hernia patch and preparation method thereof

Abstract

The present invention provides a braided hernia patch for preventing adhesion and promoting repair and a preparation method thereof. First, polytetrafluoroethylene filaments are uniformly wrapped on the surface of high-strength core yarns to obtain core-shell composite yarns, and then the core-shell composite yarns and high-strength yarns are woven into a double-sided structural fabric in a weaving manner to obtain a mesh fabric with high-strength yarns on one side and core-shell composite yarns on the other side; finally, the mesh fabric is subjected to low-temperature pressure plastic film forming treatment to obtain a braided hernia patch. The present invention adopts core-shell composite yarns in combination with weaving molding and low-temperature pressure plastic film forming processes to obtain a braided hernia patch with a sparse high-strength mesh structure on one side and a dense polytetrafluoroethylene mesh film structure on the other side, realizing the integration of anti-adhesion and support functions; the braided hernia patch solves the problems of mismatch between the mechanical and biomedical properties of existing hernia patches and poor application performance, and has the softness, bending tolerance and foldability required for the patch, and has broad market application prospects.

Description

Technical Field

[0001] The invention relates to the technical field of medical materials, and in particular to an anti-adhesion, repair-promoting braided hernia patch and a preparation method thereof. Background Art

[0002] Hernia refers to the breakage or weakening of the peritoneum that supports the internal organs at a certain position due to surgical injury or disease, which causes the internal organs in the abdomen to protrude out of the body through the broken or weakened part, forming a local mass. Hernia generally cannot heal itself. In severe cases, it affects the patient's walking and normal activities, posing a serious threat to human health and life. If not treated in time, it can lead to intestinal ischemia and necrosis and endanger life. At present, the use of patch materials to cover the damaged area is an ideal method for repairing hernias in clinical practice, that is, opening an opening at the site where the hernia occurs, pushing the organs squeezed into the site back into the abdominal cavity, and then placing a mesh fabric made of biocompatible material in the opening and fixing it in place by suturing or other means.

[0003] In the prior art, the hernia patches used clinically mainly include polypropylene fiber mesh braids and expanded polytetrafluoroethylene, but both have certain defects. When the polypropylene patch is used to repair the full-thickness defect of the abdominal wall, the patch must be isolated from the visceral tissue. If it is in direct contact with the visceral organs, it can cause more serious abdominal adhesions, digestive tract obstruction, and may even erode the intestinal wall, causing intestinal fistula, causing pain to the patient and even requiring a second operation. The polytetrafluoroethylene patch has no supporting force, and the damaged part of the abdominal wall is more likely to relapse. In addition, the expanded polytetrafluoroethylene anti-adhesion patch allows bacteria to pass through, but phagocytes cannot pass through and tissues cannot grow into it, so it cannot tolerate infection.

[0004] The invention patent (publication number CN 102068325A) discloses a composite anti-adhesion hernia patch and its preparation method, including a polypropylene patch and an expanded polytetrafluoroethylene spunbond patch, and the polypropylene patch and the expanded polytetrafluoroethylene anti-adhesion patch are sutured into one piece by expanded polytetrafluoroethylene thread. Although the patent can solve the adhesion problem of the polypropylene patch, the softness of the polypropylene patch itself is lost due to the operation of superimposing two layers of materials, which increases the rigidity of the patch. The invention patent (publication number CN 104947305A) discloses a hernia patch and its preparation method, which is to use a degradable polymer monofilament and a non-degradable polymer monofilament to composite weave and form, and heat set at 120-150°C to obtain a hernia patch; the high temperature hot pressing fusion used in the preparation method destroys the mesh structure of the original patch, which is not conducive to the growth and penetration of fibrous tissue. In addition, the current hernia patches mostly have the problem of mechanical and biomedical mismatch.

[0005] In view of this, it is necessary to design an improved anti-adhesion, repair-promoting braided hernia patch and a preparation method thereof to solve the above problems. Summary of the invention

[0006] The purpose of the present invention is to provide a braided hernia patch with anti-adhesion and repair-promoting properties and a preparation method thereof. A core-shell composite yarn with a high-strength core yarn and an outer layer of polytetrafluoroethylene filaments is used, and a braiding molding process and a low-temperature pressure plastic film-forming process are used to weave a braided hernia patch with anti-adhesion, repair-promoting and supporting functions, so as to solve the problems of mismatch between mechanical and biomedical properties and poor adaptability and application performance of hernia patches in the prior art.

[0007] To achieve the above-mentioned object of the invention, the present invention provides a method for preparing a braided hernia patch that prevents adhesion and promotes repair, comprising the following steps:

[0008] S1. preparing a core-shell composite yarn; uniformly wrapping polytetrafluoroethylene filaments on the surface of a high-strength core yarn to obtain a core-shell composite yarn; the coverage rate of the polytetrafluoroethylene filaments of the core-shell composite yarn on the high-strength core yarn is 90% to 95%;

[0009] S2, weaving the high-strength yarn and the core-shell composite yarn obtained in step S1 into a double-sided structural fabric by weaving to obtain a mesh fabric with one side being the high-strength yarn and the other side being the core-shell composite yarn;

[0010] S3. The mesh fabric obtained in step S2 is subjected to low-temperature pressure plastic film forming treatment at 50-70° C., so that a dense polytetrafluoroethylene mesh film is formed on one side of the core-shell composite yarn in the braided hernia patch, thereby obtaining an anti-adhesion and repair-promoting braided hernia patch.

[0011] As a further improvement of the present invention, one side of the high-strength yarn in the braided hernia patch is a sparse high-strength mesh structure with an average pore size ranging from 600 to 900 μm.

[0012] As a further improvement of the present invention, one side of the core-shell composite yarn in the braided hernia patch is a dense mesh film structure with an average pore size ranging from 20 to 100 μm.

[0013] As a further improvement of the present invention, in step S1, in the core-shell composite yarn, the fineness of the high-strength core yarn is 140-280D, and the fineness of the polytetrafluoroethylene filament is 50-100D.

[0014] As a further improvement of the present invention, in step S3, the time of the low-temperature pressure plastic film forming treatment is 10 to 20 minutes.

[0015] As a further improvement of the present invention, in step S2, the weaving of the double-sided structural fabric specifically includes the following steps: (1) On a knitting machine, the core-shell composite yarn is inserted into the 1st, 3rd, 4th, 6th, 7th, 9th, 10th, 12th, 13th, 15th, 16th, and 18th paths, and the high-strength yarn is inserted into the 2nd, 5th, 8th, 11th, 14th, and 17th paths; (2) The two yarns are passed through the yarn guide hooks respectively, and the tension is adjusted so that the tension of the core-shell composite yarn is greater than the tension of the high-strength yarn, and the yarns are fed under the needle plate and fixed; (3) The needles are cast on, the fabric width is preset, and the core-shell composite yarn and the high-strength yarn are added to the machine head in turn, and the needle cast on comb and weight are hung; (4) The weaving of the double needle plate and double-sided mesh composite structure is started until the double-sided structural fabric of a certain size is woven.

[0016] As a further improvement of the present invention, in step S2, the surface of the high-strength yarn is loaded with a repair agent, and the repair agent includes one of chitosan, collagen fiber, and silk fibroin fiber.

[0017] As a further improvement of the present invention, in step S1, the specific preparation process of the core-shell composite yarn is to adopt S-twist and Z-twist collaborative yarn-making process to evenly wrap the polytetrafluoroethylene filaments on the surface of the high-strength core wire; the high-strength core wire includes one of polypropylene filaments, polyethylene filaments, and polyester filaments; in step S2, the raw material of the high-strength yarn includes one of polypropylene, polyethylene, and polyester.

[0018] A woven hernia patch that prevents adhesion and promotes repair, prepared by any of the preparation methods described above, wherein the woven hernia patch is a double-sided structural fabric integrally formed by a warp knitting process, wherein one side of the double-sided structural fabric is a sparse high-strength mesh structure, and the other side is a dense polytetrafluoroethylene mesh film structure, and the raw materials of the woven hernia patch include core-shell composite yarns, wherein the core layer of the core-shell composite yarns is a high-strength core wire, and the outer layer is a polytetrafluoroethylene filament.

[0019] As a further improvement of the present invention, in the core-shell composite yarn, the polytetrafluoroethylene filaments are compounded on the surface of the high-strength core wire by uniform wrapping to achieve complete covering of the high-strength core wire; the raw material of the braided hernia patch also includes high-strength yarn.

[0020] The beneficial effects of the present invention are:

[0021] 1. The anti-adhesion and repair-promoting braided hernia patch provided by the present invention and its preparation method are as follows: first, polytetrafluoroethylene filaments are uniformly wrapped on the surface of high-strength core wires to obtain core-shell composite yarns, and then the core-shell composite yarns and high-strength yarns are woven into a double-sided structural fabric in a weaving manner to obtain a mesh fabric with one side being high-strength yarns and the other side being core-shell composite yarns, and finally the mesh fabric is subjected to low-temperature pressure plastic film forming treatment to obtain an anti-adhesion and repair-promoting braided hernia patch. The present invention adopts a core-shell composite yarn with a high-strength core wire and an outer layer of polytetrafluoroethylene filaments, and cooperates with a weaving molding process and a low-temperature pressure plastic film forming process to obtain a braided hernia patch with a sparse high-strength mesh structure on one side and a dense polytetrafluoroethylene mesh film structure on the other side, realizing the integration of the anti-adhesion and support functions required for the patch, and solving the problems of mismatch between mechanical and biomedical properties, and poor adaptability and application performance of hernia patches in the prior art.

[0022] 2. The present invention obtains a core-shell composite yarn with a high-strength core yarn and a surface-coated polytetrafluoroethylene filament by regulating and controlling the filament and spinning process parameters. The core-shell composite yarn and the high-strength yarn cooperate to improve the structural stability and mechanical properties of the braided hernia patch, so that it has good mechanical strength, fatigue resistance and wrinkle resistance. The present invention uses a braided hernia patch constructed by high-strength yarn and core-shell composite yarn. One side is a hydrophobic, highly anti-fouling polytetrafluoroethylene material, which forms a super-lubricating film under low temperature pressure, has good anti-adhesion properties, has long-term stability when in contact with organs, and is not easy to form adhesions; the other side is a sparse high-strength mesh structure with good tissue growth, so that the hernia patch grows firmly in the abdominal wall after implantation, and the micropore diameter of the mesh structure is smaller than the diameter of the tissue cells, which can induce the tissue cells to enter and grow to form a new endometrium.

[0023] 3. The anti-adhesion and repair-promoting woven hernia patch of the present invention is entirely made of yarn structure, with reasonable design, simple structure, easy use and high yield rate; it is integrally constructed by a weaving process, the preparation method is simple and easy to implement, and it has the potential for industrial mass production; and the woven hernia patch retains the mesh structure of the traditional hernia patch, and also maintains the softness required for the patch, and is resistant to bending and folding, and can be cut to the required size, and has excellent market application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the overall structure and double-sided partial enlarged structure of the anti-adhesion and repair-promoting braided hernia patch of the present invention.

[0025] Figure 2 It is a schematic diagram of the structure of the core-shell composite yarn obtained by the S-twist and Z-twist collaborative yarn-forming process of the present invention.

[0026] Reference numerals

[0027] 100-anti-adhesion, repair-promoting braided hernia patch; 110-sparse high-strength mesh structure; 120-dense polytetrafluoroethylene mesh film structure; 130-core-shell composite yarn; 131-polytetrafluoroethylene filament; 132-high-strength core wire. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solutions and advantages of the present invention more clear, the present invention is described in detail below with reference to the accompanying drawings and specific embodiments.

[0029] It should also be noted that, in order to avoid obscuring the present invention due to unnecessary details, only structures and / or processing steps closely related to the scheme of the present invention are shown in the drawings, while other details that are not closely related to the present invention are omitted.

[0030] In addition, it should be noted that the terms "comprises", "includes" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or apparatus that includes a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or apparatus.

[0031] A method for preparing a braided hernia patch 100 that prevents adhesion and promotes repair comprises the following steps:

[0032] S1, preparing a core-shell composite yarn 130; uniformly wrapping the polytetrafluoroethylene filament 131 on the surface of the high-strength core filament 132 to obtain a core-shell composite yarn 130, such as Figure 2 As shown; the coverage rate of the polytetrafluoroethylene filament 131 of the core-shell composite yarn 130 on the high-strength core wire 132 is 90% to 95%; through this process, the polytetrafluoroethylene filament 131 is repeatedly wrapped around the high-strength core wire 132 to achieve a complete covering effect without core leakage;

[0033] S2, weaving the high-strength yarn and the core-shell composite yarn obtained in step S1 into a double-sided structural fabric by weaving to obtain a mesh fabric with one side of the high-strength yarn and the other side of the core-shell composite yarn 130; the raw material of the high-strength yarn includes one of polypropylene, polyethylene, and polyester;

[0034] S3. The mesh fabric obtained in step S2 is subjected to low-temperature pressure plastic film forming treatment at 50-70° C., so that a dense polytetrafluoroethylene mesh film is formed on one side of the core-shell composite yarn in the braided hernia patch, thereby obtaining a braided hernia patch 100 that prevents adhesion and promotes repair.

[0035] In particular, the present invention adopts a core-shell composite yarn 130 with a high-strength core wire 132 as the core wire and a polytetrafluoroethylene filament 132 as the outer layer, and cooperates with a weaving molding process and a low-temperature pressure plastic film forming process to obtain a woven hernia patch with a sparse high-strength mesh structure 110 on one side and a dense polytetrafluoroethylene mesh film structure 120 on the other side, thereby realizing the integration of the anti-adhesion and support functions required for the patch, and solving the problems of hernia patches in the prior art such as mismatch between mechanical and biomedical properties and poor adaptability and application performance.

[0036] Specifically, in step S3, the low temperature pressure plastic film forming treatment time is 10 to 20 minutes, so that a dense polytetrafluoroethylene film 130 is formed on one side of the core-shell composite yarn 130 in the braided hernia patch. Through the low temperature pressure plastic film forming casting film forming method, the thermal movement of the polytetrafluoroethylene molecular chain in the core-shell composite yarn 130 is accelerated, and its ductility is improved, so that a super lubricating film is formed on one side of the polytetrafluoroethylene material, the anti-adhesion effect of the patch is improved, and the bonding force between the polytetrafluoroethylene material and the high-strength polymer material is increased, and the structural integrity and stability of the braided hernia patch are improved; and the low temperature pressure plastic film forming treatment is different from the high temperature hot pressing process, and will not cause damage to the sparse high-strength mesh structure 110 and other structures and properties of the braided hernia patch.

[0037] In the anti-adhesion and repair-promoting braided hernia patch 100, one side of the high-strength yarn is a sparse high-strength mesh structure 110, whose average pore size ranges from 600 to 900 μm; one side of the core-shell composite yarn 130 is a dense mesh film structure, whose average pore size ranges from 20 to 100 μm. The braided hernia patch constructed with high-strength yarn and core-shell composite yarn 130 has one side made of hydrophobic and highly anti-fouling polytetrafluoroethylene material, which forms a super-lubricating film under low temperature pressure, has good anti-adhesion properties, has long-term stability when in contact with organs, and is not easy to form adhesions; the other side is a high-strength mesh structure with good tissue growth, so that the hernia patch grows firmly in the abdominal wall after implantation, and the micropore diameter of the mesh structure is smaller than the diameter of tissue cells, which can induce tissue cells to enter and grow to form a new endometrium.

[0038] In step S1, in the core-shell composite yarn 130, the fineness of the high-strength core filament 132 is 140-280D, and the fineness of the polytetrafluoroethylene filament 131 is 50-100D. By adjusting the filament and spinning process parameters, the core-shell composite yarn 130 with the high-strength core filament 132 as the core layer and the polytetrafluoroethylene filament 131 as the surface is obtained. Through the coordinated cooperation of the high-strength core filament 132 and the polytetrafluoroethylene filament 132, the structural stability and mechanical properties of the braided hernia patch are improved, so that the braided hernia patch has good mechanical strength, bending resistance and folding properties.

[0039] In step S1, the specific preparation process of the core-shell composite yarn 130 is to use S-twist and Z-twist synergistic yarn-making process to evenly wrap the polytetrafluoroethylene filament 131 on the surface of the high-strength core wire 132; the high-strength core wire 132 includes one of polypropylene filament, polyethylene filament, and polyester filament.

[0040] In some specific embodiments, a hollow spindle coating machine and two groups of hollow spindles are used to spin the core-shell composite yarn 130, and the high-strength core wire 132 is inserted along the upper and lower hollow spindles. The wrapping twist direction is configured to be the same direction or the reverse direction (cross). The lower spindle twist direction is selected as S twist, and the upper spindle is respectively selected as S twist and Z twist configuration, so as to achieve bidirectional coating of the polytetrafluoroethylene filament 131 around the high-strength core wire 132.

[0041] In step S2, the weaving of the double-sided structural fabric specifically includes the following steps: (1) On a knitting machine, insert the core-shell composite yarn 130 into the 1st, 3rd, 4th, 6th, 7th, 9th, 10th, 12th, 13th, 15th, 16th, and 18th paths, and insert the high-strength yarn into the 2nd, 5th, 8th, 11th, 14th, and 17th paths; (2) Pass the above two yarns through the yarn guide hooks respectively, adjust the tension so that the tension of the core-shell composite yarn 130 is greater than the tension of the high-strength yarn (the mesh size can be adjusted according to the length of the raw yarn), feed them under the needle plate, and fix them; (3) Casting, preset the fabric width, add the core-shell composite yarn 130 and the high-strength yarn to the machine head in turn, hang the cast-on comb, and hang the weight; (4) Start weaving the double-needle plate and double-sided mesh composite structure until a double-sided structural fabric of a certain size is woven. Among them, the tension in step (2), the fabric width in step (3) and the size of the double-sided structural fabric in step (4) can all be flexibly adjusted according to actual needs.

[0042] In some specific embodiments, in step S2, the surface of the high-strength yarn is loaded with a repair agent, and the repair agent includes one of chitosan, collagen fiber, and silk fibroin fiber; the repair agent plays a role in repairing wounds and sterilizing and disinfecting in the application of hernia patches.

[0043] See also Figure 1 As shown, a braided hernia patch 100 for preventing adhesion and promoting repair is a double-sided structural fabric integrally formed by a warp knitting process, one side of the double-sided structural fabric is a sparse high-strength mesh structure 110, and the other side is a dense polytetrafluoroethylene mesh film structure 120. The raw materials of the braided hernia patch include core-shell composite yarn 130 and high-strength yarn. The core layer of the core-shell composite yarn 130 is a high-strength core wire 132, and the outer layer is a polytetrafluoroethylene filament 131. In the core-shell composite yarn 130, the polytetrafluoroethylene filament 131 is compounded on the surface of the high-strength core wire 132 by uniform wrapping, so as to achieve complete covering of the high-strength core wire 132.

[0044] The anti-adhesion, repair-promoting braided hernia patch 100 is entirely made of yarn structure, with reasonable design, simple structure, easy use and high yield rate; it is integrally constructed and formed using a braiding process, the preparation method is simple and easy to implement, and it has the potential for industrial mass production; and the braided hernia patch retains the mesh structure of traditional hernia patches, maintains the softness required for the patch, and is resistant to bending and folding, and can be cut to the required size, and has excellent market application prospects.

[0045] Example 1

[0046] This embodiment provides a method for preparing a braided hernia patch 100 that prevents adhesion and promotes repair, comprising the following steps:

[0047] S1. Prepare core-shell composite yarn 130; uniformly wrap polytetrafluoroethylene filaments 131 on the surface of polypropylene core wire by S-twist and Z-twist synergistic yarn-forming process to obtain core-shell composite yarn 130; wherein, the coverage rate of polytetrafluoroethylene filaments 131 on polypropylene core wire of core-shell composite yarn 130 is 92%, the fineness of polypropylene core wire is 200D, and the fineness of polytetrafluoroethylene filaments 131 is 80D; the synergistic yarn-forming process is specifically as follows:

[0048] A core-shell composite yarn 130 is spun by using a hollow spindle covering machine and two groups of hollow spindles. The core yarn is inserted along the upper and lower hollow spindles. The wrapping twist direction is configured to be the same direction or the opposite direction (cross). The lower spindle twist direction is selected as S twist, and the upper spindle is selected to be S twist and Z twist respectively, so that the polytetrafluoroethylene filament 131 is bidirectionally covered around the polypropylene core wire.

[0049] S2. The polypropylene yarn and the core-shell composite yarn obtained in step S1 are woven into a double-sided structural fabric by weaving to obtain a mesh fabric with one side being the polypropylene yarn and the other side being the core-shell composite yarn. The specific weaving method is as follows: (1) On a flat knitting machine, the core-shell composite yarn 130 is inserted into the 1st, 3rd, 4th, 6th, 7th, 9th, 10th, 12th, 13th, 15th, 16th, and 18th paths, and the polypropylene yarn is inserted into the 2nd, 5th, 8th, 11th, 14th, and 17th paths; (2) The two aforementioned yarns are passed through the yarn guide hooks respectively, and the tension is adjusted so that the tension of the core-shell composite yarn 130 is greater than the tension of the polypropylene yarn, and the yarns are fed under the needle plate and fixed; (3) The needles are cast on, the fabric width is preset, the core-shell composite yarn 130 and the polypropylene yarn are added to the machine head in turn, and a cast-on comb and a weight are hung on the needle plate; (4) The weaving of the double needle plate and double-sided mesh composite structure is started to obtain a double-sided structural fabric;

[0050] S3. The mesh fabric obtained in step S2 is subjected to low-temperature pressure plastic film forming treatment at 50° C. for 15 minutes to obtain a braided hernia patch 100 that prevents adhesion and promotes repair.

[0051] Example 2

[0052] This embodiment provides a method for preparing an anti-adhesion, repair-promoting woven hernia patch 100. Compared with Example 1, the difference lies in that in step S3, the temperature of the low-temperature pressure plastic film forming treatment is 70°C; the rest is roughly the same as Example 1 and will not be repeated here.

[0053] Comparative Example 1

[0054] Comparative Example 1 provides a method for preparing a braided hernia patch. Compared with Example 1, the difference is that all polypropylene yarns are used to braid the polypropylene patch, and the rest is roughly the same as Example 1, which will not be repeated here.

[0055] Comparative Example 2

[0056] Comparative Example 2 provides a method for preparing a braided hernia patch. Compared with Example 1, the difference is that all polytetrafluoroethylene filaments are used to braid the polytetrafluoroethylene patch, and the rest is roughly the same as Example 1, which will not be repeated here.

[0057] Comparative Example 3

[0058] Comparative Example 3 provides a method for preparing a braided hernia patch. Compared with Example 1, the difference is that the patch is woven entirely with core-shell composite yarns, and the rest is roughly the same as Example 1, which will not be repeated here.

[0059] Comparative Example 4

[0060] Comparative Example 4 provides a method for preparing a woven hernia patch. Compared with Example 1, the difference is that in step S3, low-temperature pressure plastic film forming treatment is not performed, and the rest is roughly the same as Example 1 and will not be repeated here.

[0061] Comparative Example 5

[0062] Comparative Example 5 provides a method for preparing a woven hernia patch. Compared with Example 1, the difference is that in step S2, polypropylene yarn and core-shell composite yarn are used separately to weave the fabric, and then the two layers of fabric are thermally bonded at high temperature (temperature is 180°C). The rest is roughly the same as Example 1 and will not be repeated here.

[0063] Comparative Example 6

[0064] Comparative Example 6 provides a method for preparing a woven hernia patch. Compared with Example 1, the difference is that in step S3, the time for low-temperature pressure plastic film forming treatment is 5 minutes, and the rest is roughly the same as Example 1, which will not be repeated here.

[0065] Comparative Example 7

[0066] Comparative Example 7 provides a method for preparing a woven hernia patch. Compared with Example 1, the difference is that in step S3, the time for low-temperature pressure plastic film forming treatment is 30 minutes, and the rest is roughly the same as Example 1, which will not be repeated here.

[0067] The braided hernia patch materials prepared in Examples 1 to 2 and Comparative Examples 1 to 7 were tested for mechanical properties, hydrophobicity of one side of the polytetrafluoroethylene material, and anti-adhesion properties; it was found that the braided hernia patches prepared in Examples 1 and 2 had good mechanical properties and structural stability, and the contact angle of one side of the polytetrafluoroethylene material was large, the hydrophobicity was good, and the anti-adhesion property was good. Although the polypropylene fiber patch prepared in Comparative Example 1 was conducive to the growth and penetration of fibrous tissue, its direct contact with the internal organs could cause abdominal adhesions, and the defects were obvious. Although the polytetrafluoroethylene patch prepared in Comparative Example 2 had good flexibility and anti-adhesion properties, it had poor support and short service life. Comparative Example 3 used core-shell composite yarns to weave a patch. After low-temperature pressure plastic film forming treatment, dense polytetrafluoroethylene films were formed on both sides of the patch, which had good anti-adhesion properties, but was not conducive to the entry and growth of tissue cells. In Comparative Example 4, no low-temperature pressure plastic film forming treatment was performed, and the hernia patch obtained had poor anti-adhesion properties. In Comparative Example 5, the hot pressing treatment was used, which destroyed the double-layer mesh structure of the hernia patch, which was not conducive to the mechanical properties and anti-adhesion properties of the patch. It can be seen from Comparative Examples 6 and 7 that if the time of low-temperature pressure plastic film-forming treatment is too short, the film-forming degree of polytetrafluoroethylene is poor, and the anti-adhesion property is relatively poor. If the time is too long, the film-forming degree is high, resulting in poor mechanical properties and flexibility of the patch.

[0068] In summary, the present invention provides a kind of anti-adhesion, pro-repair braided hernia patch and its preparation method, firstly, polytetrafluoroethylene filaments are uniformly wrapped on the surface of high-strength core wires to obtain core-shell composite yarns, and then the high-strength yarns and core-shell composite yarns are woven into double-sided structural fabrics in a weaving manner to obtain a mesh fabric with high-strength yarns on one side and core-shell composite yarns on the other side; finally, the mesh fabric is subjected to low-temperature pressure plastic film forming treatment to obtain a braided hernia patch that prevents adhesion and promotes repair. The present invention adopts a core-shell composite yarn with a high-strength core wire and a polytetrafluoroethylene filament as the outer layer, and cooperates with a weaving molding process and a low-temperature pressure plastic film forming process to obtain a braided hernia patch with a sparse high-strength mesh structure on one side and a dense polytetrafluoroethylene mesh film structure on the other side, thereby realizing the integration of the anti-adhesion and support functions required for the patch. One side of the braided hernia patch is made of hydrophobic, highly anti-fouling polytetrafluoroethylene material, which forms a super-lubricating film under low temperature pressure, has good anti-adhesion properties, has long-term stability when in contact with organs, and is not easy to form adhesions; the other side is a high-strength mesh structure with good tissue ingrowth, so that the hernia patch grows firmly in the abdominal wall after implantation, and the micropore diameter of the mesh structure is smaller than the diameter of tissue cells, which can induce tissue cells to enter and grow to form a new endometrium. The braided hernia patch solves the problems of hernia patches in the prior art, such as mismatch between mechanical and biomedical properties, and poor adaptability and application performance.

[0069] The above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solution of the present invention.

Claims

1. A method for preparing a braided hernia patch that prevents adhesion and promotes repair, characterized in that: The following steps are involved: S1. Prepare core-shell composite yarn; uniformly wrap polytetrafluoroethylene filaments on the surface of high-strength core wires to obtain core-shell composite yarns; the coverage rate of polytetrafluoroethylene filaments on the high-strength core wires of the core-shell composite yarn is 90% to 95%; the fineness of the high-strength core wires is 140 to 280 D, and the fineness of the polytetrafluoroethylene filaments is 50 to 100 D; the high-strength core wires include one of polypropylene filaments, polyethylene filaments, and polyester filaments; S2, weaving the high-strength yarn and the core-shell composite yarn obtained in step S1 into a double-sided structural fabric by weaving to obtain a mesh fabric with one side being the high-strength yarn and the other side being the core-shell composite yarn; the raw material of the high-strength yarn includes one of polypropylene, polyethylene, and polyester; S3. The mesh fabric obtained in step S2 is subjected to low-temperature pressure plastic film forming treatment at 50-70°C for 10-20 min, so that a dense polytetrafluoroethylene mesh film is formed on one side of the core-shell composite yarn in the braided hernia patch, thereby obtaining a braided hernia patch that prevents adhesion and promotes repair; one side of the core-shell composite yarn in the braided hernia patch is a dense mesh film structure with an average pore size range of 20-100 µm.

2. The method for preparing the anti-adhesion and repair-promoting braided hernia patch according to claim 1, characterized in that: One side of the high-strength yarn in the braided hernia patch is a sparse high-strength mesh structure with an average pore size ranging from 600 to 900 μm.

3. The method for preparing the anti-adhesion and repair-promoting braided hernia patch according to claim 1, characterized in that: In step S2, the surface of the high-strength yarn is loaded with a repair agent, and the repair agent includes one of chitosan, collagen fiber, and silk fibroin fiber.

4. The method for preparing the anti-adhesion and repair-promoting braided hernia patch according to claim 1, characterized in that: In step S1, the specific preparation process of the core-shell composite yarn is to use S-twist and Z-twist synergistic yarn-making process to evenly wrap the polytetrafluoroethylene filaments on the surface of the high-strength core yarn.

5. The method for preparing the anti-adhesion and repair-promoting braided hernia patch according to claim 1, characterized in that: In step S2, the weaving of the double-sided structural fabric specifically includes the following steps: (1) On a knitting machine, the core-shell composite yarn is inserted into the 1st, 3rd, 4th, 6th, 7th, 9th, 10th, 12th, 13th, 15th, 16th, and 18th paths, and the high-strength yarn is inserted into the 2nd, 5th, 8th, 11th, 14th, and 17th paths; (2) The two yarns are passed through the yarn guide hooks respectively, and the tension is adjusted so that the tension of the core-shell composite yarn is greater than the tension of the high-strength yarn, and the yarns are fed under the needle plate and fixed; (3) The needles are cast on, the fabric width is preset, the core-shell composite yarn and the high-strength yarn are added to the machine head in turn, and the needle cast on comb and weight are hung; (4) The weaving of the double needle plate and double-sided mesh composite structure is started until the double-sided structural fabric of a certain size is woven.

6. A braided hernia patch for preventing adhesion and promoting repair prepared by the preparation method according to any one of claims 1 to 5, characterized in that: The braided hernia patch is a double-sided structural fabric formed in one piece by a warp knitting process, one side of the double-sided structural fabric is a sparse high-strength mesh structure, and the other side is a dense polytetrafluoroethylene mesh film structure. The raw materials of the braided hernia patch include core-shell composite yarns, the core layer of the core-shell composite yarns is a high-strength core wire, and the outer layer is a polytetrafluoroethylene filament.

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