Controlled release disc and transdermal drug delivery device for transdermal drug delivery

Abstract

The present invention relates to the technical field of medical equipment. The present invention discloses a controlled release disc for transdermal drug delivery and a transdermal drug delivery device. The controlled release disc comprises: a disc body, a central drug delivery cavity and an annular negative pressure adsorption cavity are arranged on the disc body, and the negative pressure adsorption cavity is located outside the central drug delivery cavity; at least one convex rib is arranged on the inner top of the negative pressure adsorption cavity, and the upper space of the negative pressure adsorption cavity is divided into at least two adsorption areas by the convex rib, and the adsorption areas are distributed along the radial direction of the disc body, and a negative pressure port connected to the adsorption area is arranged on the negative pressure adsorption cavity; the negative pressure adsorption cavity is arranged to stretch the skin to the adsorption area under the action of negative pressure, and fit with the surface of the adsorption area. The present invention achieves the technical effect of improving the adsorption stability of the disc body on the skin and reducing the possibility of the disc body falling off from the skin, thereby solving the problem in the related art that the controlled release disc for transdermal drug delivery is easy to fall off when it is adsorbed and fixed to the skin.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a controlled release disc and a transdermal drug delivery device for transdermal drug delivery. Background Art

[0002] In transdermal drug delivery, a controlled release disc used for drug delivery is adsorbed on the human skin for fixation. In the related art, the controlled release disc has an annular adsorption cavity. After the controlled release disc is attached to the skin surface, a negative pressure is formed in the adsorption cavity to stretch the skin into the adsorption cavity, thereby fixing the controlled release disc on the skin surface. However, this type of controlled release disc is prone to fall off when adsorbed and fixed on the skin, affecting the subsequent drug delivery process. Summary of the invention

[0003] The main purpose of the present invention is to provide a controlled-release disc for transdermal drug delivery, so as to solve the problem in the related art that the controlled-release disc for transdermal drug delivery is easy to fall off when being adsorbed and fixed on the skin.

[0004] In order to achieve the above object, the present invention provides a controlled release disc for transdermal administration, the controlled release disc comprising:

[0005] A disc body, wherein the disc body is provided with a central drug delivery cavity and an annular negative pressure adsorption cavity, wherein the negative pressure adsorption cavity is located outside the central drug delivery cavity;

[0006] The inner top of the negative pressure adsorption chamber is provided with at least one convex rib, and the upper space of the negative pressure adsorption chamber is divided into at least two adsorption areas by the convex rib, and the adsorption areas are distributed along the radial direction of the disk body, and the negative pressure adsorption chamber is provided with a negative pressure port connected with the adsorption area;

[0007] The negative pressure adsorption chamber is configured to stretch the skin to the adsorption area under the action of negative pressure and make the skin fit with the surface of the adsorption area.

[0008] Furthermore, the surface of the adsorption area includes an annular top surface and two oppositely distributed annular side surfaces, the two annular side surfaces are respectively connected to two sides of the annular top surface, and an involute opening structure is formed between the two annular side surfaces.

[0009] Furthermore, the annular side surface and the annular top surface are both configured as concave arc surfaces;

[0010] One end of the convex rib away from the annular top surface is arranged as an outwardly convex top arc surface, and both sides of the top arc surface are respectively smoothly transitionally connected with the corresponding annular side surfaces.

[0011] Furthermore, the convex rib is set as one, and the upper space of the negative pressure adsorption chamber is divided into two adsorption areas by the convex rib, and the two adsorption areas are respectively a first adsorption area and a second adsorption area distributed from the inside to the outside.

[0012] Furthermore, the first adsorption area and the second adsorption area are symmetrical along the center line of the convex rib.

[0013] Furthermore, the adsorption space of the first adsorption region is larger than the adsorption space of the second adsorption region.

[0014] Furthermore, the top end of the convex rib is located on the center line of the negative pressure adsorption chamber.

[0015] Furthermore, the protruding height h of the rib relative to the top of the adsorption area is determined based on the following formula:

[0016]

[0017] Wherein, R1 is the radius of the surface of the first adsorption area and the second adsorption area, R2 is the radius of the top arc surface of the convex rib, and d is the center distance between the first adsorption area and the second adsorption area.

[0018] Furthermore, the convex rib extends along the circumference of the disk body, and at least one notch is provided on the convex rib, and the negative pressure port corresponds to the notch;

[0019] When the skin is stretched to fit the top of the convex rib under the action of negative pressure, the first adsorption area and the second adsorption area can be connected through the gap.

[0020] According to another aspect of the present invention, a transdermal drug delivery device is provided, comprising the above-mentioned controlled-release disc for transdermal drug delivery.

[0021] In the embodiment of the present invention, a central drug delivery cavity and an annular negative pressure adsorption cavity are arranged on the disc body, and the negative pressure adsorption cavity is located outside the central drug delivery cavity; at least one convex rib is arranged on the inner top of the negative pressure adsorption cavity, and the upper space of the negative pressure adsorption cavity is divided into at least two adsorption areas by the convex rib, and the adsorption areas are distributed along the radial direction of the disc body, and a negative pressure port connected to the adsorption area is arranged on the negative pressure adsorption cavity; the negative pressure adsorption cavity is arranged to stretch the skin to the adsorption area under the action of negative pressure, and fit with the surface of the adsorption area, on the one hand, the skin is first stretched to contact with the top of the convex rib under the action of negative pressure, and at the same time, the adsorption area forms a negative pressure cavity, and the skin can continue to stretch along the adsorption area under the action of negative pressure until the skin fits with the surface of the adsorption area, so that the skin can produce a bending deformation when it fits with the negative pressure adsorption cavity, and the disc body is stably adsorbed and fixed on the skin, thereby achieving the technical effect of improving the adsorption stability of the disc body on the skin and reducing the possibility of the disc body falling off from the skin, thereby solving the problem that the controlled release disc for transdermal drug delivery in the related art is easy to fall off when it is adsorbed and fixed on the skin;

[0022] In addition, since the convex ribs form multiple mutually isolated adsorption areas in the negative pressure adsorption cavity, when the skin contacts the top of the convex ribs, each adsorption area can form an independent negative pressure cavity. Even if the pressure of some negative pressure cavities decreases during drug administration, the remaining negative pressure cavities can still provide a certain adsorption capacity, which can further reduce the possibility of the controlled release disc falling off.

[0023] Furthermore, after the convex ribs are arranged, the partial structural strength of the negative pressure adsorption cavity on the controlled release disc is increased, which can improve the anti-deformation capability of the controlled release disc and further improve the adsorption stability of the controlled release disc. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The accompanying drawings constituting a part of the present invention are used to provide a further understanding of the present invention, so that other features, purposes and advantages of the present invention become more obvious. The accompanying drawings of the exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0025] Figure 1 is a schematic diagram of the isometric structure of a controlled-release disc according to an embodiment of the present invention;

[0026] Figure 2 is a schematic diagram of a partial cross-sectional structure of a controlled-release disc according to an embodiment of the present invention;

[0027] Among them, 1 is a disc body, 2 is a central drug delivery cavity, 3 is a negative pressure adsorption cavity, 30 is an adsorption area, 31 is a first adsorption area, 32 is a second adsorption area, 301 is an annular side surface, 302 is an annular top surface, 4 is a convex rib, 401 is a top arc surface, 402 is a notch, and 5 is a negative pressure port. DETAILED DESCRIPTION

[0028] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0029] It should be noted that the terms "first", "second", etc. in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the numbers used in this way can be interchanged under appropriate circumstances to facilitate the embodiments of the present invention described herein.

[0030] In the present invention, the directions or positional relationships indicated by the terms "upper", "lower", "inner", etc. are based on the directions or positional relationships shown in the drawings. These terms are mainly used to better describe the present invention and its embodiments, and are not used to limit the indicated devices, elements or components to have a specific direction, or to be constructed and operated in a specific direction.

[0031] In addition, some of the above terms may be used to express other meanings in addition to indicating orientation or positional relationship. For example, the term "on" may also be used to express a certain dependency or connection relationship in some cases. For those skilled in the art, the specific meanings of these terms in the present invention can be understood according to specific circumstances.

[0032] In addition, the terms "disposed", "provided with", "connected", "fixed" and the like should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection, or an electrical connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be an internal connection between two devices, elements or components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0033] In addition, the term "plurality" shall mean two or more.

[0034] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0035] In transdermal drug delivery, a controlled release disc used for drug delivery is adsorbed on the human skin for fixation. In the related art, the controlled release disc has an annular adsorption cavity. After the controlled release disc is attached to the skin surface, a negative pressure is formed in the adsorption cavity to stretch the skin into the adsorption cavity, thereby fixing the controlled release disc on the skin surface. However, this type of controlled release disc is prone to fall off when adsorbed and fixed on the skin, affecting the subsequent drug delivery process.

[0036] To solve the above technical problems, Figure 1 and Figure 2 As shown, an embodiment of the present invention provides a controlled release disc for transdermal administration, the controlled release disc comprising:

[0037] The disc body 1 is provided with a central drug delivery cavity 2 and an annular negative pressure adsorption cavity 3, and the negative pressure adsorption cavity 3 is located outside the central drug delivery cavity 2;

[0038] At least one convex rib 4 is provided at the inner top of the negative pressure adsorption chamber 3, and the upper space of the negative pressure adsorption chamber 3 is divided into at least two adsorption areas 30 by the convex rib 4. The adsorption areas 30 are distributed along the radial direction of the disc body 1, and a negative pressure port 5 communicating with the adsorption areas 30 is provided on the negative pressure adsorption chamber 3;

[0039] The negative pressure adsorption chamber 3 is configured to stretch the skin to the adsorption area 30 under the action of negative pressure and make the skin fit with the surface of the adsorption area 30 .

[0040] In this embodiment, the controlled release disc is used in conjunction with the vacuum system of the transdermal drug delivery treatment device. Under the action of the vacuum system, the controlled release disc can be adsorbed on the skin surface of the human body, thereby performing transdermal drug delivery. In order to meet the adsorption and fixation functions and drug delivery functions of the controlled release disc, Figure 1 and Figure 2 As shown, the disc body 1 of the controlled release disc in this embodiment is mainly divided into two parts, namely, the central drug delivery chamber 2 located in the middle and the annular negative pressure adsorption chamber 3 located outside the central drug delivery chamber 2. The central drug delivery chamber 2 and the negative pressure adsorption chamber 3 are separated. When in use, the negative pressure adsorption chamber 3 is connected to the vacuum system. After the disc body 1 is attached to the skin, the negative pressure adsorption chamber 3 and the skin surface form a closed chamber. At this time, under the action of the vacuum system, negative pressure is generated in the negative pressure adsorption chamber 3, so that the skin is stretched into the negative pressure adsorption chamber 3, thereby adsorbing and fixing the disc body 1 on the skin surface. The central drug delivery chamber 2 located in the middle plays the role of drug delivery to the skin.

[0041] On this basis, in order to improve the adsorption stability of the negative pressure adsorption chamber 3, as Figure 1 and Figure 2 As shown, in this embodiment, at least one convex rib 4 is provided on the inner top of the negative pressure adsorption chamber 3, and the convex rib 4 can be a ring structure. When the convex rib 4 is provided as one, as shown in FIG. Figure 2As shown, the upper space of the negative pressure adsorption chamber 3 is divided into two adsorption areas 30 by the arrangement of the convex ribs 4, and the two adsorption areas 30 are respectively located on both sides of the convex ribs 4. When the tray 1 is attached to the skin, under the negative pressure of the vacuum system, the skin corresponding to the negative pressure adsorption chamber 3 is stretched into the negative pressure adsorption chamber 3 and contacts the top of the convex ribs 4. At this time, two closed chambers are formed between the two adsorption areas 30 and the skin on both sides of the convex ribs 4. Under the further negative pressure of the vacuum system, the skin on both sides of the convex ribs 4 will be further stretched into the adsorption area 30 and gradually fit with the surface of the adsorption area 30. At this point, the pressure in the negative pressure adsorption chamber 3 reaches the maximum, and the tray 1 will be firmly adsorbed on the human skin to achieve the expected use effect.

[0042] In this embodiment, since the two adsorption areas 30 form two independent and closed chambers after the skin contacts the top of the convex rib 4, in order for the two chambers to generate negative pressure under the action of the vacuum system, both chambers need to be connected to the vacuum system. In one embodiment, two negative pressure ports 5 may be provided on the disc body 1, and the two negative pressure ports 5 may be connected to the two adsorption areas 30 respectively. In another embodiment, a negative pressure port 5 may be provided on the disc body 1, and the negative pressure port 5 is connected to the two adsorption areas 30 at the same time through a specific channel. It can be understood that the above description of the connection method between the negative pressure port 5 and the adsorption area 30 is not restrictive, as long as a functional structure that can meet the above is adopted.

[0043] In addition, it should be noted that the disc body 1 can be set as a circular disc body or a square disc body, and its specific shape can be designed according to needs. Correspondingly, the central drug delivery cavity 2 can also be circular or square, and the negative pressure adsorption cavity 3 can be annular or square. The cross-section of the convex rib 4 can be a rectangular structure, a conical structure, a round-headed cylindrical structure, etc.

[0044] On one hand, the present invention achieves the purpose of first stretching the skin to contact with the top of the convex rib 4 under the action of negative pressure, and at the same time forming a negative pressure cavity in the adsorption area 30, so that the skin can continue to stretch along the adsorption area 30 under the action of negative pressure until the skin fits with the surface of the adsorption area 30, so that the skin can be bent when it fits with the negative pressure adsorption cavity 3, and the disc body 1 is stably adsorbed and fixed on the skin, thereby achieving the technical effect of improving the adsorption stability of the disc body 1 on the skin and reducing the possibility of the disc body 1 falling off from the skin, thereby solving the problem in the related art that the controlled-release disc for transdermal drug delivery is easy to fall off when it is adsorbed and fixed on the skin;

[0045] In addition, since the convex ribs 4 form a plurality of mutually isolated adsorption areas 30 in the negative pressure adsorption chamber 3, when the skin contacts the top of the convex ribs 4, each adsorption area 30 can form an independent negative pressure chamber. Even if the pressure of some negative pressure chambers decreases during the drug administration process, the remaining negative pressure chambers can still provide a certain adsorption capacity, which can further reduce the possibility of the controlled release disc falling off.

[0046] Furthermore, after the convex ribs 4 are arranged, the partial structural strength of the negative pressure adsorption cavity 3 on the controlled release disc is increased, which can improve the anti-deformation capability of the controlled release disc and further improve the adsorption stability of the controlled release disc.

[0047] According to the deformation ability of the skin, in order to make the skin fit better with the surface of the adsorption area 30, the contour of the adsorption area 30 is further improved in this embodiment. Figure 2 As shown, in this embodiment, the surface of the adsorption area 30 includes an annular top surface 302 and two relatively distributed annular side surfaces 301 , the two annular side surfaces 301 are respectively connected to the two sides of the annular top surface 302 , and an involute opening structure is formed between the two annular side surfaces 301 .

[0048] In this embodiment, by setting the adsorption area 30 to a gradually opening structure, it can be more closely fitted to the shape of the skin after being stretched, thereby improving the fit with the skin, and further improving the adsorption stability of the disc body 1 on the skin. It should be noted that if the opening of the adsorption area 30 is too small, the adsorption of the skin will be poor and the skin will be easily injured, while if the opening is too large, the adsorption stability will be reduced, so it is necessary to select a suitable opening of the adsorption area 30.

[0049] On the basis of the above implementation mode, in order to further improve the adsorption capacity, as Figure 2 As shown, the annular side surface 301 and the annular top surface 302 in this embodiment are both configured to be concave arc surfaces, so that the skin can have a certain convex curvature after being stretched to fit the annular side surface 301 and the annular top surface 302, and the convex part of the skin and the concave part of the annular side surface 301 and the annular top surface 302 can cooperate with each other to play a certain limiting role, thereby further improving the stability of the disc body 1 adsorbed on the skin.

[0050] Since the skin needs to contact the top of the rib 4 (i.e., the end of the rib 4 away from the annular top surface 302) first after being stretched into the negative pressure adsorption chamber 3, in order to make the skin fit better on the surface of the rib 4 and avoid the skin being stretched, Figure 2 As shown, in this embodiment, the end of the rib 4 away from the annular top surface 302 is set as an outwardly convex top arc surface 401, and both sides of the top arc surface 401 are smoothly transitionally connected to the corresponding annular side surface 301.

[0051] In this embodiment, the top arc surface 401 of the convex rib 4 is adapted to the deformation capacity of the skin. It is understandable that when the radius of the top arc surface 401 is small, the deformation caused by the skin fitting to the convex rib 4 is larger, which easily causes the skin to be stretched, and when the radius of the top arc surface 401 is large, its limiting effect on the skin will be reduced, resulting in reduced adsorption stability of the disc body 1, so the radius of the top arc surface 401 of the convex rib 4 also needs to be reasonably designed according to actual conditions.

[0052] In this embodiment, the convex ribs 4 can be provided in multiple numbers, and the multiple convex ribs 4 are distributed at intervals along the radial direction of the disc body 1, and adsorption areas 30 can be formed between the convex ribs 4 and between the convex ribs 4 and the side walls of the negative pressure adsorption chamber 3. It can be understood that, under the premise of satisfying the skin's deformation ability and not stretching the skin, the more convex ribs 4 there are, the more adsorption areas 30 are formed, and after the skin is stretched to fit each adsorption area 30, the more bends are generated in the skin, and the more stable the disc body 1 is adsorbed and fixed to the skin. However, since the size of the negative pressure adsorption chamber 3 is limited and the deformation ability of the skin is limited, the specific number of convex ribs 4 can be determined according to actual conditions, and this embodiment does not limit it here.

[0053] In one embodiment of the rib 4, Figure 1 and Figure 2 As shown, the convex rib 4 is provided as one, and the upper space of the negative pressure adsorption chamber 3 is divided into two adsorption areas 30 by the convex rib 4. The two adsorption areas 30 are respectively a first adsorption area 31 and a second adsorption area 32 distributed from the inside to the outside.

[0054] In this embodiment, the space sizes of the first adsorption area 31 and the second adsorption area 32 may be consistent. When the space sizes are consistent, the first adsorption area 31 and the second adsorption area 32 may be symmetrical along the midline of the rib 4. Of course, in the case of asymmetry, the space sizes of the first adsorption area 31 and the second adsorption area 32 may be consistent by adjusting the surface profiles of the first adsorption area 31 and the second adsorption area 32.

[0055] In another embodiment, the space sizes of the first adsorption area 31 and the second adsorption area 32 are not consistent. In this embodiment, the adsorption space of the first adsorption area 31 can be relatively large, that is, the adsorption space of the first adsorption area 31 is larger than the adsorption space of the second adsorption area 32. Since the first adsorption area 31 is the part of the negative pressure adsorption chamber 3 close to the central drug delivery chamber 2, when the space of the first adsorption area 31 is relatively large, the first adsorption area 31 has a greater adsorption capacity for the skin, thereby preventing the drug solution in the central drug delivery chamber 2 from entering the first adsorption area 31 and the second adsorption area 32 under the action of negative pressure, that is, preventing the drug solution from entering the negative pressure adsorption chamber 3 under the action of negative pressure.

[0056] In another embodiment, the space of the second adsorption area 32 may be larger than the space of the first adsorption area 31. Since the second adsorption area 32 is closer to the outside of the tray body 1, the adsorption capacity of the second adsorption area 32 is larger when the space is larger, so that the air outside is not easy to enter the second adsorption area 32, that is, it is not easy to cause the negative pressure adsorption chamber 3 to leak, which can improve the adsorption stability of the tray body 1.

[0057] From the above description, it can be known that when the space of the second adsorption area 32 is sufficient to stably adsorb the disc body 1 on the skin, the space of the first adsorption area 31 should be increased so that the liquid medicine in the central medication cavity 2 is not easy to enter the negative pressure adsorption cavity 3.

[0058] Because the skin first contacts the top of the convex rib 4 under the action of negative pressure, and then under the further action of negative pressure, both sides of the skin will be stretched upward along the convex rib 4. Therefore, in order to avoid excessive adsorption force on one side of the skin, the top of the convex rib 4 in this embodiment is located on the center line of the negative pressure adsorption chamber 3.

[0059] On this basis, the sizes of the spaces corresponding to the first adsorption area 31 and the second adsorption area 32 can be adjusted by adjusting the inner surface contours of the first adsorption area 31 and the second adsorption area 32 .

[0060] When the inner contour of the adsorption area 30 is close to a circular arc, the radius of the adsorption area 30 will affect the adsorption stability of the disc body 1 and whether the skin will be strained. At the same time, the protruding height of the convex rib 4 will also affect the adsorption stability of the disc body 1 and whether the skin will be strained. When the protruding height of the convex rib 4 remains unchanged, the larger the radius of the adsorption area 30, the smaller the radius of the top arc surface 401 of the convex rib 4. At this time, although the disc body 1 can be more stably adsorbed on the skin, the skin will also be more easily strained. Conversely, when the radius of the adsorption area 30 is smaller, the radius of the top arc surface 401 of the convex rib 4 is larger, and the adsorption stability of the disc body 1 is reduced.

[0061] Based on this, the radius of the adsorption area 30 can be determined according to the required adsorption capacity of the disc body 1, and then the protruding height of the rib 4 can be adjusted based on the premise of safety of use, so that the disc body 1 can be stably adsorbed on the skin without stretching the skin.

[0062] In one embodiment, the protrusion height h of the rib 4 relative to the top of the adsorption area 30 is determined based on the following formula:

[0063]

[0064] R1 is the radius of the surface of the first adsorption area 31 and the second adsorption area 32 , R2 is the radius of the top arc surface 401 of the convex rib 4 , and d is the center distance between the first adsorption area 31 and the second adsorption area 32 .

[0065] In order to enable the adsorption area 30 to still generate negative pressure under the action of the vacuum system after forming a closed chamber, Figure 1 As shown, in this embodiment, the convex rib 4 extends along the circumference of the disc body 1, and at least one notch 402 is provided on the convex rib 4, and the negative pressure port 5 corresponds to the notch 402; when the skin is stretched to fit with the top of the convex rib 4 under the action of negative pressure, the first adsorption area 31 and the second adsorption area 32 can be connected through the notch 402.

[0066] Specifically, by providing the notch 402 on the convex rib 4, after the adsorption area 30 forms a closed chamber, the adjacent chambers can still be connected through the notch 402. That is, the negative pressure port 5 located at the notch 402 can simultaneously generate negative pressure in each chamber under the action of the vacuum system, so that the skin corresponding to each adsorption area 30 can be stretched at the same time, so as to avoid injury caused by inconsistent stretching time of the skin at different positions.

[0067] According to another aspect of the present invention, a transdermal drug delivery device is provided, comprising the above-mentioned controlled-release disc for transdermal drug delivery.

[0068] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Within the spirit and principle of the present invention, any modification, equivalent replacement, improvement, etc. made shall be included in the protection scope of the present invention.

Claims

1. A controlled release disc for transdermal administration, characterized in that: include: A disc body, wherein a central drug delivery cavity and an annular negative pressure adsorption cavity are arranged on the disc body, and the negative pressure adsorption cavity is located outside the central drug delivery cavity; The inner top of the negative pressure adsorption chamber is provided with at least one convex rib, and the upper space of the negative pressure adsorption chamber is divided into at least two adsorption areas by the convex rib, and the adsorption areas are distributed along the radial direction of the disk body, and the negative pressure adsorption chamber is provided with a negative pressure port connected with the adsorption area; The upper space of the negative pressure adsorption chamber is divided into two adsorption areas by a convex rib, and the two adsorption areas are respectively a first adsorption area and a second adsorption area distributed from the inside to the outside; The convex rib extends along the circumference of the disk body, and at least one notch is provided on the convex rib, and the negative pressure port corresponds to the notch; When the skin is stretched to fit the top of the convex rib under the action of negative pressure, the first adsorption area and the second adsorption area can be connected through the gap; The negative pressure adsorption chamber is configured to stretch the skin to the adsorption area under the action of negative pressure and make it fit with the surface of the adsorption area; The surface of the adsorption area includes an annular top surface and two oppositely distributed annular side surfaces, the two annular side surfaces are respectively connected to two sides of the annular top surface, and an involute opening structure is formed between the two annular side surfaces; The annular side surface and the annular top surface are both configured as concave arc surfaces; One end of the convex rib away from the annular top surface is configured as an outwardly convex top arc surface, and both sides of the top arc surface are smoothly transitionally connected to the corresponding annular side surfaces respectively; The protruding height h of the rib relative to the top of the adsorption area is determined based on the following formula: Wherein, R1 is the radius of the surface of the first adsorption area and the second adsorption area, R2 is the radius of the top arc surface of the convex rib, and d is the center distance between the first adsorption area and the second adsorption area.

2. The controlled-release disc for transdermal administration according to claim 1, characterized in that: The first adsorption area and the second adsorption area are symmetrical along a center line of the rib.

3. The controlled-release disc for transdermal administration according to claim 1, characterized in that: The adsorption space of the first adsorption region is larger than the adsorption space of the second adsorption region.

4. The controlled-release disc for transdermal administration according to claim 1, characterized in that: The top end of the convex rib is located on the center line of the negative pressure adsorption chamber.

5. A transdermal drug delivery device, characterized in that: The invention comprises a controlled-release disc for transdermal administration as claimed in any one of claims 1 to 4.

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