A double gel sebum film and preparation method thereof

Abstract

The present invention relates to the field of gel, and specifically discloses a double gel sebum membrane and a preparation method thereof. The double gel sebum membrane is composed of a gel backing layer, a gel functional layer and a protective layer arranged in sequence. The preparation method of the double gel sebum membrane is as follows: the components are mixed in sequence, and cross-linked to form a backing layer gel and a functional layer gel respectively, and then the functional layer is attached to the dried backing layer gel to obtain the double gel sebum membrane. The composition of the present invention has the advantage of being green and environmentally friendly; in addition, the preparation method of the present invention also has the advantages of being simple, convenient and easy to industrialize.

Description

Technical Field

[0001] The invention relates to the field of gel, in particular to a double gel sebum membrane and a preparation method thereof. Background Art

[0002] Transdermal patch is a third drug delivery system after oral administration and injection. It refers to a drug delivery route in which drugs penetrate and absorb into the human body through the skin and achieve disease prevention and treatment through blood circulation.

[0003] Transdermal patches are mainly composed of three parts: a backing layer, a matrix layer, and an anti-adhesive layer. They are external preparations with large drug loading, strong moisturizing properties, and can be repeatedly applied. Among them, the backing layer of transdermal patches is mostly made of high-density non-woven fabrics. High-density non-woven fabrics have certain flexibility and stiffness, are breathable and water-proof, and help to exert the efficacy of the patch.

[0004] However, with the release of national policies and changes in the market environment, the use of degradable environmentally friendly and energy-saving materials in industry has become an inevitable trend, and non-woven fabrics containing polypropylene, polyester, polyester and other ingredients are not easy to degrade and are likely to have an impact on the environment. Therefore, there is still room for improvement. Summary of the invention

[0005] In order to make the patch green, environmentally friendly and degradable, the present application provides a double gel sebum membrane and a preparation method thereof.

[0006] In a first aspect, the present application provides a double gel sebum membrane, which adopts the following technical solution:

[0007] A double gel sebum membrane, which is composed of a gel backing layer, a gel efficacy layer and a protective layer arranged in sequence;

[0008] The gel backing layer is made of the following components in parts by weight:

[0009] 15-25 parts of glucomannan, 15-30 parts of chondrus crispus extract, 1-5 parts of sodium alginate, and 2-8 parts of ionic crosslinking agent;

[0010] The gel efficacy layer is made of the following components in parts by weight:

[0011] 3-8 parts of sodium polyacrylate, 15-30 parts of glycerol, 0.05-0.3 parts of disodium ethylenediaminetetraacetic acid, 1-3 parts of cellulose thickener, 0.3-1 parts of carrageenan, 0.1-0.4 parts of aluminum glycolate, 0.1-0.4 parts of humic acid, 50-70 parts of water, and 0.55-25 parts of effective ingredients.

[0012] By adopting the above technical scheme, the double gel sebum membrane is prepared with the above substances, and the above substances are all degradable substances, so that the prepared double gel sebum membrane is degradable and has a certain environmental protection function.

[0013] At the same time, the gel backing layer uses glucomannan, carrageenan, and sodium alginate extract as the gel matrix, and adds an ionic crosslinking agent that can improve the binding force of hydroxyl- or carboxyl-containing polymer materials, which is beneficial to increasing the crosslinking density of the gel and improving the mechanical strength of the gel backing layer; the gel efficacy layer uses fiber thickeners, sodium polyacrylate, and carrageenan as the gel matrix and glycerin as a humectant, which is beneficial to enhancing the moisture retention of the fluid gel; aluminum glycolate is used as a crosslinking agent, and the pH value of the gel is adjusted to adjust the curing time of the gel, which is convenient for subsequent coating operations.

[0014] By using sodium alginate, glucomannan and chondrus extract as raw materials for the gel backing layer respectively, the sodium polyacrylate and aluminum glyoxylate in the gel functional layer form a complex with the glucomannan, chondrus and sodium alginate extract in the gel backing layer, thereby enhancing the bonding strength between the gel functional layer and the gel backing layer, making the prepared double gel sebum membrane easier to peel off at one time during use and less likely to remain in the fitted area.

[0015] Preferably, the effective ingredients include the following components in parts by weight: 0.11-5 parts of melaleuca leaf oil, 0.11-5 parts of geranium oil, 0.11-5 parts of purslane extract, 0.11-5 parts of witch hazel extract, and 0.11-5 parts of licorice extract.

[0016] By adopting the above technical scheme, by adding melaleuca leaf oil and geranium oil for synergistic compounding, the plant volatile oil in the melaleuca leaf oil has a broad-spectrum antibacterial effect, and the geranium oil contains a large amount of terpenoids and flavonoids, which have good antibacterial and anti-inflammatory effects. The synergistic compounding with the melaleuca leaf oil can further enhance the antibacterial and anti-inflammatory effects of the composition; by adding purslane extract, witch hazel extract, and licorice extract for synergistic compounding, it is beneficial to inhibit the activity of metalloproteinases induced by inflammation, increase the expression of collagen, repair damaged epidermal keratinocytes and fibroblasts, and repair epidermal damage caused by acne; by adding purslane extract, witch hazel extract, licorice extract and melaleuca extract and geranium extract for synergistic compounding, it is also beneficial to enhance the hydration of the skin, accelerate the migration of the effective ingredients to the surface skin, and make the effective ingredients in the double gel sebum film more easily absorbed by the skin, thereby helping to give full play to the efficacy of the double gel sebum film.

[0017] Preferably, in the gel backing layer, the ionic crosslinking agent is prepared by mixing monovalent metal salt, divalent metal salt, starch or protein.

[0018] By adopting the above technical scheme, using the above-mentioned various substances as ion cross-linking agents, the cations in the ion exchanger and the various functional groups in glucomannan and carrageenan extract form a hydrogel with a three-dimensional network structure, which is beneficial to improve the binding force of the gel backing layer and enhance the mechanical strength of the gel without affecting the torsion angle of the double gel sebum film.

[0019] Preferably, in the gel backing layer, the ionic crosslinking agent is composed of potassium chloride, calcium chloride and starch in a mass ratio of (2-4): (2-4): (1-2).

[0020] By adopting the above technical scheme, potassium chloride, calcium chloride and starch are used as ionic crosslinking agents in a specific proportion, which is beneficial to further improve the density of the three-dimensional network structure inside the gel and improve the mechanical strength of the double gel sebum membrane. At the same time, it is not easy for the flowing gel functional layer to penetrate into the gel backing layer due to the higher mechanical strength, thereby affecting the adhesive fit of the two layers of gel and reducing the bonding strength.

[0021] Preferably, in the gel efficacy layer, the humic acid includes one or more of tartaric acid, citric acid and malic acid.

[0022] By adopting the above technical scheme, using one or more of the above substances as humic acid, it is beneficial to adjust the release rate of aluminum ions in aluminum glycolate and control the curing time of the gel; at the same time, the multi-functional groups in humic acid are beneficial to increase the cross-linking density between aluminum glycolate and the gel matrix, enhance the cohesion of the gel, and improve the mechanical strength. It is not easy for the gel to be easily formed due to the low mechanical strength of the gel functional layer, and it is easy to remain in the fitting area during use.

[0023] Preferably, in the gel efficacy layer, the humic acid is composed of tartaric acid and citric acid in a mass ratio of (0.05-0.1):(0.05-0.3).

[0024] By adopting the above technical scheme, tartaric acid and citric acid are used as humic acid in a specific ratio, and various functional groups in humic acid can form complexes with aluminum glycolate, which is beneficial to improve the mechanical strength of the gel efficacy layer and the gel backing layer, while not affecting the permeability of the effective ingredients in the gel efficacy layer.

[0025] Preferably, in the gel functional layer, the cellulose thickener includes one or more of cross-linked sodium hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and hydroxymethyl cellulose.

[0026] By adopting the above technical solution and using one or more of the above substances as cellulose thickeners, it is beneficial to increase the cross-linking density of the gel functional layer and enhance the mechanical properties of the double gel sebum film.

[0027] In a second aspect, the present application provides a method for preparing a double gel sebum film, using the following technical solution:

[0028] A method for preparing a double gel sebum film comprises the following steps:

[0029] Step 1, preparation of backing layer gel:

[0030] Step 1-1, adding glucomannan, chondrus crispus extract, sodium alginate, and an ionic crosslinking agent into a first container, heating to 45-75° C., keeping warm, then adding an ionic crosslinking agent, adjusting the pH to 5.5-7.5, stirring, and obtaining a backing layer gel;

[0031] Step 2, preparation of the efficacy layer gel:

[0032] Step 2-1, add sodium polyacrylate, glycerol, disodium ethylenediaminetetraacetate, cellulose thickener, carrageenan, aluminum glycolate, humic acid, and water into a third container and stir evenly;

[0033] Step 2-2, adding the functional ingredients into the third container and stirring evenly to obtain the functional layer gel;

[0034] Step 3, assembly of double gel sebum mask:

[0035] Step 3-1, coating the backing layer gel prepared in step 1 on a substrate and drying to form a gel backing layer (1);

[0036] Step 3-2, coating the functional layer gel prepared in step 2 on the side of the gel backing layer (1) away from the substrate to form a gel functional layer (2), and at the same time covering the side of the gel functional layer (2) away from the gel backing layer with a protective layer (3), and allowing to stand and solidify to obtain a double gel sebum film.

[0037] By adopting the above technical scheme, the components are mixed in sequence, cross-linked to form a gel backing layer and a gel efficacy layer respectively, and then the gel efficacy layer is coated on the dry gel backing layer, so that the flowing gel efficacy layer penetrates into the dry gel backing layer, and the gel backing layer and the gel efficacy layer are cross-linked and bonded, which is conducive to the preparation of a double gel sebum film with good adhesion, strong permeability and good quality.

[0038] In summary, this application has the following beneficial effects:

[0039] 1. The double gel sebum membrane is prepared by using the above substances. The prepared double gel sebum membrane is degradable and has certain environmental protection functions.

[0040] 2. The gel backing layer uses glucomannan, chondrus crispus extract and sodium alginate as gel matrix, and adds ionic crosslinking agents that can improve the binding force of hydroxyl- or carboxyl-containing polymer materials, which is beneficial to increasing the crosslinking density of the gel and improving the mechanical strength of the gel backing layer; the gel efficacy layer uses fiber thickener, carrageenan and sodium polyacrylate as gel matrix and glycerin as humectant, which is beneficial to enhancing the moisture retention of the fluid gel; aluminum glycolate is used as a crosslinking agent, and the gel curing time is adjusted by adjusting the pH value of the gel, which is convenient for subsequent coating operations. By using sodium polyacrylate, aluminum glyoxylate, glucomannan, carrageenan extract and sodium alginate as raw materials, the sodium polyacrylate and aluminum glyoxylate in the gel functional layer form a complex with the glucomannan, carrageenan extract and sodium alginate in the gel backing layer, thereby enhancing the bonding strength between the gel functional layer and the gel backing layer, making the prepared double gel sebum membrane easier to peel off at one time during use and less likely to remain in the fitting area; at the same time, it is not easy for the double gel sebum membrane to have too high strength due to excessive complexation, and the curvature of the double gel sebum membrane is reduced, thereby affecting the fitting degree of the double gel sebum membrane.

[0041] 3. By adding purslane extract, witch hazel extract, licorice extract, melaleuca extract and geranium extract for synergistic combination, it is beneficial to improve the transdermal permeability of the active ingredients to the surface skin, so that the active ingredients can migrate to the skin as much as possible and exert the effect of the double gel sebum film. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Figure 1 It is a schematic diagram of the overall structure of a double gel sebum membrane in the present invention.

[0043] Description of reference numerals:

[0044] 1. Gel backing layer; 2. Gel functional layer; 3. Protective layer. DETAILED DESCRIPTION

[0045] The present application is further described in detail below with reference to the embodiments.

[0046] The raw materials of the following examples and comparative examples are all commercially available, as follows:

[0047] Melaleuca alternifolia leaf oil was purchased from Jiangxi Global Natural Flavor Co., Ltd.;

[0048] Geranium oil was purchased from Shanghai Yuanye Biotechnology Co., Ltd.;

[0049] Portulaca oleracea extract was purchased from Shandong Tongyuan Gonghe Biotechnology Co., Ltd.;

[0050] Hamamelis virginiana extract was purchased from Shaanxi Huike Plant Development Co., Ltd.;

[0051] Licorice extract was purchased from Xi'an Tianbao Biotechnology Co., Ltd.;

[0052] Scutellaria baicalensis extract was purchased from Guangzhou Belka Biotechnology Co., Ltd.;

[0053] Soapberry extract was purchased from Shaanxi New Horizon Biotechnology Co., Ltd.;

[0054] Myrrh extract, frankincense extract, vinca extract, and chondrus extract were purchased from Fufeng Snot Biotechnology Co., Ltd.;

[0055] Diethylaminoethyl dextran was purchased from Sigma-Aldrich (Shanghai) Trading Co., Ltd.;

[0056] Guar gum was purchased from Hebei Zhongzhisheng Biotechnology Co., Ltd.;

[0057] The CAS number of cross-linked sodium carboxymethylcellulose is 74811-65-7;

[0058] The CAS number of xanthan gum is 11138-66-2;

[0059] The CAS number of glucomannan is 11078-31-2;

[0060] The CAS number of sodium polyacrylate is 9003-04-7;

[0061] The CAS number of sodium alginate is 9005-38-3;

[0062] The CAS number of xanthan gum is 9062-07-1;

[0063] The CAS number of glycerol is 56-81-5;

[0064] The CAS number of EDTA disodium is 139-33-3;

[0065] The CAS number of carrageenan is 11114-20-8;

[0066] The CAS number of aluminum glycolate is 41354-48-7;

[0067] The CAS number of aluminum chloride is 7446-70-0;

[0068] The CAS number of potassium chloride is 7447-40-7;

[0069] The CAS number of calcium chloride is 22691-02-7;

[0070] The CAS number of starch is 9005-25-8;

[0071] The CAS number of magnesium chloride is 7786-30-3;

[0072] The CAS number of sodium chloride is 7647-14-5;

[0073] The CAS number of bovine serum albumin is 9048-46-8;

[0074] The CAS number of quinic acid is 77-95-2;

[0075] The CAS number of salicylic acid is 69-72-7;

[0076] The CAS number of tartaric acid is 526-83-0;

[0077] The CAS number of citric acid is 6915-15-7.

[0078] Example 1

[0079] A double gel sebum membrane consists of a gel backing layer 1, a gel functional layer 2 and a protective layer 3 arranged in sequence; the gel backing layer 1 is located on a side away from the skin, the gel functional layer 2 is located on a side in contact with the skin, and the protective layer 3 is in contact with the side of the gel functional layer 2 away from the gel backing layer 1.

[0080] The gel backing layer 1 is made of the following components:

[0081] Glucomannan 15kg, Chondrus crispus extract 15kg, Sodium alginate 5kg, Ionic crosslinking agent 5kg;

[0082] The gel efficacy layer 2 is made of the following quality components:

[0083] Sodium polyacrylate 3kg, glycerol 15kg, disodium ethylenediaminetetraacetic acid 0.05kg, cellulose thickener 1kg, carrageenan 0.3kg, aluminum glycolate 0.1kg; humic acid 0.1kg, water 50kg, effective ingredients 0.55kg.

[0084] In this embodiment, the ionic crosslinking agent is a mixture of 2kg potassium chloride, 2kg calcium chloride, and 1kg starch; the effective ingredient is a mixture of 0.11kg melaleuca leaf oil, 0.11kg geranium oil, 0.11kg purslane extract, 0.11kg witch hazel extract, and 0.11kg licorice extract; the humic acid is a mixture of 0.05kg tartaric acid and 0.05kg citric acid; and the cellulose thickener is cross-linked sodium hydroxymethylcellulose.

[0085] A method for preparing a double gel sebum film comprises the following steps:

[0086] Step 1, preparation of backing layer gel:

[0087] Step 1-1, add glucomannan, carrageenan extract and sodium alginate into an emulsifying pot, heat to 45° C., and keep the temperature at 45° C.;

[0088] Step 1-2, add potassium chloride, calcium chloride and starch into a stirring pot, stir and dissolve with a glass rod to prepare an aqueous solution;

[0089] Step 1-3, adding the aqueous solution prepared in step 1-2 to an emulsifying pot, and adjusting the pH to 5.5 using 0.1 mol / L sodium hydroxide solution and 0.1 mol / L hydrochloric acid solution, and then stirring at a speed of 50 r / min for 5 minutes to obtain a backing layer gel;

[0090] Step 2, preparation of the efficacy layer gel:

[0091] Step 2-1, add sodium polyacrylate, glycerol, disodium ethylenediaminetetraacetic acid, cross-linked sodium hydroxymethylcellulose, carrageenan, aluminum glycolate, tartaric acid, citric acid, and water into the total emulsification pot, and stir at a speed of 50 r / min for 15 minutes;

[0092] Step 2-2, add Melaleuca alternifolia leaf oil, geranium oil, Portulaca oleracea extract, Hamamelis virginiana extract, and Licorice extract into the total emulsification pot, and stir at a speed of 50 r / min for 10 minutes to obtain an efficacy layer gel;

[0093] Step 3, assembly of double gel sebum mask:

[0094] Step 3-1, coating the backing layer gel prepared in step 1 on the substrate into a 2 mm thick gel layer, placing it in an oven at a temperature of 60° C. to dry for 20 minutes, and then placing it in a dryer to cool to room temperature at room temperature to form a gel backing layer 1;

[0095] Step 3-2, coating the functional layer gel prepared in step 2 on the side of the gel backing layer (1) away from the substrate to form a gel functional layer (2), and then covering the side of the gel functional layer (2) away from the gel backing layer with a protective layer (3), and allowing to stand and solidify to obtain a double gel sebum film.

[0096] Example 2

[0097] A double gel sebum membrane consists of a gel backing layer 1, a gel functional layer 2 and a protective layer 3 arranged in sequence; the gel backing layer 1 is located on a side away from the skin, the gel functional layer 2 is located on a side in contact with the skin, and the protective layer 3 is in contact with the side of the gel functional layer 2 away from the gel backing layer 1.

[0098] The gel backing layer 1 consists of the following components in mass:

[0099] Glucomannan 20kg, Chondrus crispus extract 30kg, Sodium alginate 10kg, Ionic crosslinking agent 10kg;

[0100] Gel efficacy layer 2 consists of the following components in quality:

[0101] 6kg sodium polyacrylate, 30kg glycerol, 0.3kg disodium ethylenediaminetetraacetic acid, 3kg cellulose thickener, 1kg carrageenan, 0.4kg aluminum glycolate; 0.4kg humic acid, 70kg water, 25kg active ingredients.

[0102] In this embodiment, the ionic crosslinking agent is a mixture of 4kg potassium chloride, 4kg calcium chloride, and 2kg starch; the effective ingredients are a mixture of 5kg melaleuca leaf oil, 5kg geranium oil, 5kg purslane extract, 5kg witch hazel extract, and 5kg licorice extract; the humic acid is a mixture of 0.1kg tartaric acid and 0.3kg citric acid; and the cellulose thickener is cross-linked sodium hydroxymethylcellulose.

[0103] A method for preparing a double gel sebum film comprises the following steps:

[0104] Step 1, preparation of backing layer gel:

[0105] Step 1-1, add glucomannan, carrageenan extract and sodium alginate into an emulsifying pot, heat to 75° C., and maintain the temperature at 75° C.;

[0106] Step 1-2, add potassium chloride, calcium chloride and starch into a stirring pot, stir and dissolve with a glass rod to prepare an aqueous solution;

[0107] Step 1-3, adding the aqueous solution prepared in step 1-2 to an emulsifying pot, and adjusting the pH to 7.5 using 0.1 mol / L sodium hydroxide solution and 0.1 mol / L hydrochloric acid solution, and then stirring at a speed of 50 r / min for 5 minutes to obtain a backing layer gel;

[0108] Step 2, preparation of the efficacy layer gel:

[0109] Step 2-1, add sodium polyacrylate, glycerol, disodium ethylenediaminetetraacetic acid, cross-linked sodium hydroxymethylcellulose, carrageenan, aluminum glycolate, tartaric acid, citric acid, and water into the total emulsification pot, and stir at a speed of 50 r / min for 15 minutes;

[0110] Step 2-2, add Melaleuca alternifolia leaf oil, geranium oil, Portulaca oleracea extract, Hamamelis virginiana extract, and Licorice extract into the total emulsification pot, and stir at a speed of 50 r / min for 10 minutes to obtain an efficacy layer gel;

[0111] Step 3, assembly of double gel sebum mask:

[0112] Step 3-1, coating the backing layer gel prepared in step 1 on the substrate into a 2 mm thick gel layer, placing it in an oven at a temperature of 60° C. to dry for 20 minutes, and then placing it in a dryer to cool to room temperature at room temperature to form a gel backing layer 1;

[0113] Step 3-2, coating the functional layer gel prepared in step 2 on the side of the gel backing layer (1) away from the substrate to form a gel functional layer (2), and then covering the side of the gel functional layer (2) away from the gel backing layer with a protective layer (3), and allowing to stand and solidify to obtain a double gel sebum film.

[0114] Example 3

[0115] A double gel sebum membrane consists of a gel backing layer 1, a gel functional layer 2 and a protective layer 3 arranged in sequence; the gel backing layer 1 is located on a side away from the skin, the gel functional layer 2 is located on a side in contact with the skin, and the protective layer 3 is in contact with the side of the gel functional layer 2 away from the gel backing layer 1.

[0116] The gel backing layer 1 consists of the following components in mass:

[0117] Glucomannan 17.5kg, Chondrus crispus extract 22.5kg, Sodium alginate 7.5kg, Ionic crosslinker 7.5kg;

[0118] Gel efficacy layer 2 consists of the following components in quality:

[0119] 4.5kg sodium polyacrylate, 22.5kg glycerol, 0.175kg disodium ethylenediaminetetraacetic acid, 2kg cellulose thickener, 0.65kg carrageenan, 0.25kg aluminum glycolate; 0.25kg humic acid, 60kg water, 12.775kg active ingredients.

[0120] In this embodiment, the ionic crosslinking agent is a mixture of 3kg potassium chloride, 3kg calcium chloride, and 1.5kg starch; the effective ingredients are a mixture of 2.555kg melaleuca leaf oil, 2.555kg geranium oil, 2.555kg purslane extract, 2.555kg witch hazel extract, and 2.555kg licorice extract; humic acid is a mixture of 0.075kg tartaric acid and 0.175kg citric acid; and the cellulose thickener is cross-linked sodium hydroxymethylcellulose.

[0121] A method for preparing a double gel sebum film comprises the following steps:

[0122] Step 1, preparation of backing layer gel:

[0123] Step 1-1, add glucomannan, carrageenan extract and sodium alginate into an emulsifying pot, heat to 60° C., and maintain the temperature at 60° C.;

[0124] Step 1-2, add potassium chloride, sodium chloride, starch, water, etc. into a stirring pot, stir and dissolve with a glass rod to prepare an aqueous solution;

[0125] Step 1-3, adding the aqueous solution prepared in step 1-2 to an emulsifying pot, and adjusting the pH to 6.5 using 0.1 mol / L sodium hydroxide solution and 0.1 mol / L hydrochloric acid solution, and then stirring at a speed of 50 r / min for 5 minutes to obtain a backing layer gel;

[0126] Step 2, preparation of the efficacy layer gel:

[0127] Step 2-1, add sodium polyacrylate, glycerol, disodium ethylenediaminetetraacetic acid, cross-linked sodium hydroxymethylcellulose, carrageenan, aluminum glycolate, tartaric acid, citric acid, and water into the total emulsification pot, and stir at a speed of 50 r / min for 15 minutes;

[0128] Step 2-2, add Melaleuca alternifolia leaf oil, geranium oil, Portulaca oleracea extract, Hamamelis virginiana extract, and Licorice extract into the total emulsification pot, and stir at a speed of 50 r / min for 10 minutes to obtain a gel efficacy layer;

[0129] Step 3, assembly of double gel sebum mask:

[0130] Step 3-1, coating the backing layer gel prepared in step 1 on the substrate into a 2 mm thick gel layer, placing it in an oven at a temperature of 60° C. to dry for 20 minutes, and then placing it in a dryer to cool to room temperature at room temperature to form a gel backing layer 1;

[0131] Step 3-2, coating the functional layer gel prepared in step 2 on the side of the gel backing layer (1) away from the substrate to form a gel functional layer (2), and then covering the side of the gel functional layer (2) away from the gel backing layer with a protective layer (3), and allowing to stand and solidify to obtain a double gel sebum film.

[0132] Example 4

[0133] A double gel sebum membrane, which is different from Example 3 in that an equal amount of Scutellaria baicalensis extract is used to replace Melaleuca alternifolia leaf oil.

[0134] Example 5

[0135] A double gel sebum membrane, which is different from Example 3 in that an equal amount of vinca roseus extract is used to replace geranium oil.

[0136] Example 6

[0137] A double gel sebum membrane, which is different from Example 3 in that an equal amount of soapberry extract is used to replace the purslane extract.

[0138] Example 7

[0139] A double gel sebum membrane, which is different from Example 3 in that an equal amount of frankincense extract is used instead of witch hazel extract.

[0140] Example 8

[0141] A double gel sebum membrane, which is different from Example 3 in that an equal amount of myrrh extract is used to replace the liquorice extract.

[0142] Example 9

[0143] A double gel sebum membrane, which is different from Example 3 in that an equal amount of sodium chloride is used instead of potassium chloride.

[0144] Example 10

[0145] A double gel sebum membrane, which is different from Example 3 in that an equal amount of magnesium chloride is used instead of calcium chloride.

[0146] Embodiment 11

[0147] A double gel sebum membrane, which is different from Example 3 in that an equal amount of bovine serum albumin is used to replace starch.

[0148] Example 12

[0149] A double gel sebum membrane, which is different from Example 3 in that tartaric acid is replaced by an equal amount of quinic acid.

[0150] Embodiment 13

[0151] A double gel sebum membrane, which is different from Example 3 in that an equal amount of salicylic acid is used instead of citric acid.

[0152] Comparative Example 1

[0153] A double gel sebum membrane, which is different from Example 3 in that an equal amount of diethylaminoethyl glucan is used to replace glucomannan.

[0154] Comparative Example 2

[0155] A double gel sebum membrane, which is different from Example 3 in that an equal amount of carrageenan is used to replace the chondrus crispus extract.

[0156] Comparative Example 3

[0157] A double gel sebum membrane, which is different from Example 3 in that an equal amount of guar gum is used to replace sodium alginate.

[0158] Comparative Example 4

[0159] A double gel sebum membrane, which is different from Example 3 in that an equal amount of xanthan gum is used to replace sodium polyacrylate.

[0160] Comparative Example 5

[0161] A double gel sebum membrane, which is different from Example 3 in that an equal amount of aluminum chloride is used to replace aluminum glycolate.

[0162] Experiment 1 Mechanical Properties

[0163] The double gel sebum membranes prepared in the above examples and comparative examples were respectively selected, and the double gel sebum membranes were cut into samples with a length × width of 115 mm * 10 mm, and the mechanical properties of the gel were tested using a texture analyzer. The texture analyzer was a Saicheng TA-3000 texture analyzer purchased from Beijing Xinyue Zhongke Technology Co., Ltd.

[0164] Tensile property test: The experimental setting parameters of the texture analyzer are: transverse axis tensile mode, A / TG probe, pre-test rate 2mm / s, test speed 2mm / s, post-test rate 10mm / s, stretching distance 140mm, each group of examples and comparative examples were measured 3 times, and the average value was taken. Among them, the larger the measured value, the stronger the tensile property of the double gel sebum film.

[0165] Strength test: The experimental parameters were set as follows: TPA mode, P / 0.5 probe, pre-test rate 1mm / s, test speed 1mm / s, post-test rate 2mm / s, trigger force 5.00g, deformation 50%, and each group of examples and comparative examples was measured 3 times, and the average value (g) was taken. The larger the measured value, the greater the strength of the double gel sebum film.

[0166] The above experimental test data are detailed in Table 1.

[0167] Experiment 2 Bending performance test

[0168] The double gel sebum membranes prepared by the above-mentioned embodiments and comparative examples were selected respectively, and the maximum torsion angle of the double gel sebum membranes was tested using a universal material testing machine. The parameters set by the testing machine are: specification: GH-959C-100kN; accuracy level: 0.5 level; maximum load: 100kN; effective force measurement range: 0.4-100% FS; force measurement accuracy: within 0.5% of the indicated value; test force resolution: 1 / 500000, unchanged throughout the whole process; effective test width: 400mm; effective stretching space: 650mm; test speed range: 0.01-300mm / min stepless speed regulation; speed accuracy: within ±0.5% of the indicated value; displacement measurement accuracy: within ±0.5% of the indicated value; deformation measurement accuracy: within ±0.5% of the indicated value. Each group of embodiments and comparative examples were measured 3 times, and the average value (°) was taken. The universal material testing machine was purchased from Instron, USA. Among them, the larger the measured value, the better the bending performance of the double gel sebum film and the higher the fit with the skin.

[0169] The above experimental test data are detailed in Table 1.

[0170] Experiment 3: Bond Strength

[0171] The double gel sebum membrane prepared by the above-mentioned embodiment and comparative example is selected respectively, and the double gel sebum membrane is cut into a long strip double gel sebum membrane with a length and width of 180mm*25mm respectively, and the long strip double gel sebum membrane is fixed on a testing machine equipped with an elongation dynamometer, and the gel backing layer and the gel functional layer of the double gel sebum membrane are peeled off by a utility knife for about 50mm, and then the peeled two ends are fixed on the clamp of the testing machine respectively, and the peeled double gel sebum membrane is placed in the center of the mobile clamp, so that the peeling angle is about 180°, and then the testing machine is started to peel off the double gel sebum membrane, and the force (N / mm) required for peeling off 100mm length is recorded, and each group of embodiments and comparative examples is tested 3 times respectively, and the average value (N / mm) is taken; observe and record the state of mutual penetration and bonding of the gel backing layer and the gel functional layer of the peeled double gel sebum membrane. The moving speed of the clamp is 50mm / min. The testing machine is purchased from Jinan Saicheng Electronic Technology Co., Ltd.

[0172] The above experimental test data are detailed in Table 1.

[0173] Experiment 4 Transdermal penetration

[0174] The frozen mouse skin was taken out and thawed, and the mouse skin was rinsed three times with 0.9% physiological saline. The mouse skin was fixed on the diffusion cell of the transdermal diffusion tester with the skin stratum corneum facing upward, and the inner layer of the mouse skin was kept in close contact with the receiving solution. The temperature of the receiving solution in the diffusion cell was set to be constant at 37.5°C, and the stirring speed was 350r / min. The double gel sebum membrane prepared in the above-mentioned embodiments and comparative examples was taken again, and the gel efficacy layer of the double gel sebum membrane was completely covered on the surface of the mouse skin stratum corneum. After 3 hours, 1 mL of the receiving solution was taken from the diffusion cell and filtered with a 0.45μm microporous filter membrane to obtain a sample to be tested. The sample to be tested was measured using high performance liquid chromatography, and the cumulative transdermal penetration (μg / cm 2 ), each group of examples and comparative examples were tested 3 times and the average value was taken (μg / cm 2 ).

[0175]

[0176] In the formula

[0177] Q is the cumulative amount of permeation per unit area (μg / cm 2 );

[0178] C is the drug mass concentration (μg / mL);

[0179] V is the total volume of the receiving solution (mL).

[0180] The above experimental test data are detailed in Table 1.

[0181] Table 1

[0182]

[0183]

[0184]

[0185]

[0186]

[0187] According to the data comparison of Example 3 and Comparative Examples 1-5 in Table 1, glucomannan, carrageenan extract, sodium alginate, sodium polyacrylate, and aluminum glycolate were added in Example 3, and the obtained double gel sebum membrane had good mechanical properties, tensile properties and hardness were 0.89, 540.6g, respectively, the maximum bending angle was 126°, and the bonding strength was 21.31N / mm. In Comparative Examples 1-5, glucomannan, carrageenan extract, sodium alginate, sodium polyacrylate, and aluminum glycolate were replaced with equal amounts of diethylaminoethyl glucan, carrageenan, guar gum, xanthan gum, and aluminum chloride, respectively, and the bonding strength and mechanical properties of the obtained double gel sebum membrane decreased, and the bending angle decreased. It was proved that only by adding glucomannan, chondrus extract and aluminum glycinate in a synergistic combination, the aluminum glycinate in the gel efficacy layer forms a complex with the glucomannan and chondrus extract in the gel backing layer, thereby enhancing the bonding strength between the gel efficacy layer and the gel backing layer, making the prepared double gel sebum film easy to peel off at one time during use and not easy to remain in the fitting area.

[0188] According to the data comparison of Example 3 and Example 4-8 in Table 1, it can be obtained that the transdermal permeability of the double gel sebum membrane prepared in Example 4-8 is reduced by replacing the melaleuca leaf oil, geranium oil, purslane extract, witch hazel extract, and licorice extract with equal amounts of Scutellaria extract, Catharanthus roseus extract, Sapindus mukorossi extract, frankincense extract, and Myrrh extract. It is proved that the synergistic compounding of melaleuca leaf oil, geranium oil, purslane extract, witch hazel extract, and licorice extract is beneficial to enhance the hydration of the skin, accelerate the migration of the functional ingredients to the surface skin, improve the permeability of the functional ingredients in the double gel sebum membrane, and give full play to the efficacy of the double gel sebum membrane. Any replacement of one of the substances cannot effectively increase the transdermal permeability of the double gel sebum membrane.

[0189] According to the data comparison between Example 3 and Examples 9-11 in Table 1, it can be seen that in Examples 9-11, potassium chloride, magnesium chloride, and bovine serum albumin are used to replace potassium chloride, calcium chloride, and starch in equal amounts, respectively, and the mechanical strength of the obtained double gel sebum membrane is increased and the torsion angle is reduced. It is proved that only by adding potassium chloride, calcium chloride, and starch in a synergistic combination can the gel strength be improved without affecting the torsion angle of the double gel sebum membrane.

[0190] According to the data comparison between Example 3 and Examples 12-13 in Table 1, it can be seen that in Examples 12-13, tartaric acid and citric acid are replaced by equal amounts of quinic acid and salicylic acid, respectively, and the mechanical strength of the prepared double gel sebum film is increased and the transdermal permeability is decreased. It is proved that only the addition of tartaric acid and citric acid in synergy is beneficial to improving the strength of the double gel sebum film without affecting the transdermal permeability of the skin.

[0191] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A double gel sebum film, characterized in that: It is composed of a gel backing layer (1), a gel functional layer (2) and a protective layer (3) which are arranged in sequence; The gel backing layer (1) is made of the following components in parts by weight: 15-25 parts of glucomannan, 15-30 parts of chondrus crispus extract, 1-5 parts of sodium alginate, and 2-8 parts of ionic crosslinking agent; The ionic crosslinking agent is prepared by mixing potassium chloride, calcium chloride, starch and water in a mass ratio of (2-4): (2-4): (1-2): (10-15); The gel efficacy layer (2) is made of the following components in parts by weight: 3-8 parts of sodium polyacrylate, 15-30 parts of glycerol, 0.05-0.3 parts of disodium ethylenediaminetetraacetic acid, 1-3 parts of cellulose thickener, 0.3-1 parts of carrageenan, 0.1-0.4 parts of aluminum glycolate, 0.1-0.4 parts of humic acid, 50-70 parts of water, 0.55-25 parts of effective ingredients; Humic acid is composed of tartaric acid and citric acid in a mass ratio of (0.05-0.1): (0.05-0.3).

2. A double gel sebum membrane according to claim 1, characterized in that: The effective ingredients include the following components in parts by weight: 0.11-5 parts of melaleuca leaf oil, 0.11-5 parts of geranium oil, 0.11-5 parts of purslane extract, 0.11-5 parts of witch hazel extract, and 0.11-5 parts of liquorice extract.

3. A double gel sebum membrane according to claim 1, characterized in that: In the gel functional layer (2), the cellulose thickener includes one or more of cross-linked sodium hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and hydroxymethyl cellulose.

4. A method for preparing a double gel sebum film according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1, preparation of backing layer gel: Step 1-1, adding glucomannan, chondrus crispus extract and sodium alginate into a first container, heating to 45-75° C., keeping warm, adding an ionic crosslinking agent, adjusting the pH to 5.5-7.5, stirring, and obtaining a backing layer gel; Step 2, preparation of the efficacy layer gel: Step 2-1, add sodium polyacrylate, glycerol, disodium ethylenediaminetetraacetate, cellulose thickener, carrageenan, aluminum glycolate, tartaric acid, citric acid, and water into a third container and stir evenly; Step 2-2, adding the functional ingredients into the third container and stirring evenly to obtain the functional layer gel; Step 3, assembly of double gel sebum mask: Step 3-1, coating the backing layer gel prepared in step 1 on a substrate and drying to form a gel backing layer (1); Step 3-2, coating the functional layer gel prepared in step 2 on the side of the gel backing layer (1) away from the substrate to form a gel functional layer (2), and at the same time covering the side of the gel functional layer (2) away from the gel backing layer with a protective layer (3), and allowing to stand and solidify to obtain a double gel sebum film.

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