A supramolecular bosine composition with multi-target anti-aging effects on skin and preparation method thereof

Abstract

The present invention belongs to the field of cosmetics, and specifically relates to a supramolecular Bose composition with multi-target anti-aging effects on the skin and a preparation method thereof. The supramolecular Bose composition includes phase A, phase B and phase C; wherein: the phase A includes: hydroxypropyl tetrahydropyrantriol, rhamnose, hydroxyproline, lactic acid, betaine, vitamin E, purified water; the phase B includes: polydimethylsiloxane, lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, coconut oil alcohol-caprylate / caprate, glyceryl stearate, caprylyl glycol; the phase C includes: Alpinia officinalis leaf extract, acetyl hexapeptide-8, soluble collagen, sodium hyaluronate cross-linked polymer, purified water. The supramolecular Bose obtained by the present invention has efficient penetration and absorption effects, and has good activity and bioavailability; in addition, the present invention verifies the anti-aging properties of the supramolecular Bose composition such as firming, anti-wrinkle, and skin rejuvenation through different skin elasticity, skin smoothness, skin wrinkle area, and wrinkle depth experiments.

Description

Technical Field

[0001] The present invention belongs to the field of cosmetics, and in particular relates to a supramolecular bosine composition having multi-target anti-aging effects on skin and a preparation method thereof. Background Art

[0002] Nowadays, consumers are paying more attention to anti-aging. Skin aging is a common skin problem, and its causes are mainly divided into endogenous and exogenous. Endogenous causes include decreased collagen synthesis, oxidation of free radicals to destroy collagen, and formation of collagen fibers by saccharified tissue collagen; exogenous causes include photoaging, air pollution, etc. The manifestation of skin structure is thinning of the epidermis, shrinkage of DEJ area, degeneration of papillary structure, reduction in the number of fibroblasts, and continuous loss of ECM. The most important of these is the shrinkage of DEJ area and the loss of ECM. The DEJ layer connects the dermis and epidermis, does not contain cell structures, and is mainly composed of IV collagen and laminin. It provides mechanical support structure for the epidermis structure, while promoting the connection and combination of the true epidermis, and serves as a channel for energy metabolism, signal transmission, and nutrient supply. ECM is the extracellular matrix, which can protect the skin from excessive tissue compression and maintain tenderness. GAGs are its main components. At present, the main anti-aging raw materials in cosmetics are vitamin A derivatives, protease, peptides, etc. Vitamin A derivatives can penetrate the epidermis, stimulate ECM, and promote collagen production. The effect is the most direct, but it will cause "early damage" such as skin desquamation. Especially for the increasingly sensitive skin of Chinese women, not only can it not fight against aging, but it may also aggravate sensitive inflammation and accelerate aging. Peptides are of various types and cover a wide range of effects, including anti-aging, repair, soothing, etc. The specific anti-aging effect is more by inhibiting neuronal transmission, with short-term wrinkle and wrinkle removal effects, and the mechanism of long-term anti-aging effect is unknown.

[0003] Therefore, based on this, the technical solution of the present invention is proposed. Summary of the invention

[0004] The first technical problem solved by the present invention is that modern urban women have an increasing demand for anti-aging, but the existing skin anti-aging technology has unclear mechanisms, irritation and sensitization, and low efficacy. A supramolecular bosine composition with multi-target skin anti-aging effects is provided, which can increase the expression of heparan sulfate proteoglycans (HS-PGs) - basement membrane proteoglycans (Perlecan), CD44 and syndecans to improve the binding force of the epidermis and the epidermis-dermis junction (DEJ), and further promote the synthesis of glycosaminoglycans (GAGs) and proteoglycans (PGs). Thus, the targeted problems related to wrinkles, sagging and aging are solved.

[0005] The second technical problem solved by the present invention is the sticky skin feeling and slow absorption of high-concentration phosphatidylcholine. Through supramolecular synergistic penetration-enhancing technology, the two delivery solvents, organic acid and amino acid, are connected by hydrogen bonds to form a stable and orderly mixture, thereby achieving the phosphatidylcholine penetration-enhancing and absorption effects and improving the bioavailability.

[0006] More specifically, the present invention provides a supramolecular bosine composition having multi-target anti-aging effects on skin, comprising phase A, phase B and phase C; wherein:

[0007] The phase A comprises the following raw materials in parts by weight: 10-20 parts of hydroxypropyl tetrahydropyrantriol (bosine), 1-5 parts of rhamnose, 0.5-2 parts of hydroxyproline, 1-6 parts of lactic acid, 1-10 parts of betaine, 0.5-5 parts of vitamin E, and 10-30 parts of purified water;

[0008] The phase B comprises the following raw materials in parts by weight: 2 to 10 parts of polydimethylsiloxane, 0.5 to 5 parts of lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 0.5 to 5 parts of coconut oil alcohol-caprylate / caprate, 1 to 3 parts of glyceryl stearate, and 0.1 to 1 part of caprylyl glycol;

[0009] The phase C comprises the following raw materials in parts by weight: 1-5 parts of Alpinia galanga leaf extract, 0.001-0.5 parts of acetyl hexapeptide-8, 0.01-2 parts of soluble collagen, 0.01-2 parts of sodium hyaluronate cross-linked polymer, and 30-55 parts of purified water.

[0010] Preferably, the phase A comprises the following raw materials in parts by weight: 15 parts of hydroxypropyl tetrahydropyrantriol, 3 parts of rhamnose, 1.5 parts of hydroxyproline, 3.5 parts of lactic acid, 5.5 parts of betaine, 2.5 parts of vitamin E, and 20 parts of purified water;

[0011] The phase B comprises the following raw materials in parts by weight: 6 parts of polydimethylsiloxane, 2.5 parts of lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 2.5 parts of coconut oil alcohol-caprylate / caprate, 2 parts of glyceryl stearate, and 0.5 parts of caprylyl glycol;

[0012] The phase C comprises the following raw materials in parts by weight: 3 parts of Alpinia galanga leaf extract, 0.25 parts of acetyl hexapeptide-8, 1 part of soluble collagen, 1 part of sodium hyaluronate cross-linked polymer, and 45 parts of purified water.

[0013] Based on the same technical concept, another solution of the present invention is to provide a method for preparing a supramolecular bosine composition having multi-target anti-aging effects on skin, the preparation method comprising:

[0014] (1) Pre-dosing process: accurately weigh hydroxypropyl tetrahydropyrantriol, rhamnose, hydroxyproline, lactic acid, betaine, vitamin E, and purified water, put them into a reactor, heat them, and stir and dissolve them to obtain phase A;

[0015] (2) Blending process: accurately weigh dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, coconut oil alcohol monocaprylate / caprate, glyceryl stearate, and caprylyl glycol and put them into another reactor, heat and stir to dissolve, and obtain phase B;

[0016] Mix phase A and phase B, homogenize and emulsify until the system is uniform, then stir and keep warm, stir and cool in sequence to obtain a blending phase;

[0017] (3) Synergistic process: maintaining the temperature, adding Alpinia galanga leaf extract, acetyl hexapeptide-8, soluble collagen, sodium hyaluronate cross-linked polymer, and purified water to the blending phase, stirring at high speed until the system is uniform and cooling; then degassing, filtering, testing, and aging in sequence to obtain the supramolecular bosin composition with multi-target anti-aging effects on the skin.

[0018] Preferably, in step (1), the temperature is raised to 70-75° C., and the homogenizing stirring time is 10-15 min.

[0019] Preferably, in step (2), the temperature is raised to 75-80° C., and the homogenizing stirring time is 30-60 min.

[0020] Preferably, in step (2), the homogenization and emulsification time is 5 to 10 minutes, the stirring and heat preservation time is 10 to 20 minutes, and the stirring and cooling to 50 to 60°C are performed.

[0021] Preferably, in step (3), the temperature is maintained at 50-60° C., the speed of high-speed stirring is 25 rpm, and the time of high-speed stirring is 15-20 min.

[0022] Preferably, in step (3), the aging time is 15 to 20 hours.

[0023] The beneficial effects of the present invention are:

[0024] 1. The present invention solves the problem that high-concentration Bossagra has a low transdermal effect. Specifically, two delivery solvents (power sources) of organic acid (lactic acid) and amino acid (hydroxyproline) are hydrogen-bonded with Bossagra, and the obtained supramolecular Bossagra has a highly efficient penetration and absorption effect, and has good activity and bioavailability (as shown in the results of Test Example 1).

[0025] 2. The present invention has creatively discovered that the binding force between the epidermis and the epidermis-dermis junction (DEJ) can be improved by increasing the expression of heparan sulfate proteoglycans (HS-PGs) - basement membrane proteoglycans (Perlecan), CD44 and syndecans, and further promoting the synthesis of glycosaminoglycans (GAGs) and proteoglycans (PGs). Through multiple target actions, the targeted problems related to wrinkles and sagging aging are solved. The present invention verifies the anti-aging properties of the supramolecular Bose-like composition such as firming, anti-wrinkle, and skin rejuvenation through different skin elasticity, skin smoothness, skin wrinkle area, and wrinkle depth experiments (as shown in the results of Test Example 2).

[0026] 3. The preparation method of the present invention is easy to operate, does not require complicated equipment, and is green and environmentally friendly.

[0027] 4. The present invention has passed corresponding human tests and efficacy verification tests, proving that the product has corresponding safety and is applicable to a wide range of groups. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0029] Figure 1 This is a data chart of the cumulative skin penetration of different groups.

[0030] Figure 2 This is a data graph of skin elasticity R2 value.

[0031] Figure 3 This is a data chart of skin elasticity R5 value.

[0032] Figure 4 It is a data chart of skin wrinkle area.

[0033] Figure 5 This is a real picture of the crow's feet of the subject at D0 time.

[0034] Figure 6 This is a real picture of the crow's feet of the test subject at D14.

[0035] Figure 7 This is a real shot of the crow's feet of the test subject at time D0 when using a commercially available product.

[0036] Figure 8 These are actual photos of crow's feet on a test subject at D14 when using a commercially available product. DETAILED DESCRIPTION

[0037] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0038] Example 1

[0039] The present invention provides a method for preparing a supramolecular bosine composition having multi-target anti-aging effects on skin, the preparation method comprising the following steps:

[0040] (1) Pre-dosing process: accurately weigh hydroxypropyl tetrahydropyrantriol, rhamnose, lactic acid, betaine, vitamin E, and purified water, put them into a water pot, heat to 70° C., and stir and dissolve them for 15 minutes to obtain phase A;

[0041] (2) Blending process: accurately weigh dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, coconut oil alcohol monocaprylate / caprate, glyceryl stearate, and caprylyl glycol, put them into an oil pan, heat to 75° C., and stir and dissolve for 60 minutes to obtain phase B;

[0042] Mix phase A and phase B, homogenize and emulsify for 5 minutes until the system is uniform, then stir and keep warm for 10 minutes, and stir and cool to 50°C to obtain a blending phase;

[0043] (3) Synergistic process: maintaining the temperature at 50°C, adding Alpinia galanga leaf extract, acetyl hexapeptide-8, soluble collagen, sodium hyaluronate cross-linked polymer, and purified water to the blending phase, stirring at 25 rpm for 15 minutes until the system is uniform and cooling to 30°C; then degassing and filtering in sequence, aging the semi-finished product at room temperature for 15 hours after the semi-finished product is tested and qualified, thereby obtaining the supramolecular bosin composition with multi-target anti-aging effects on the skin.

[0044] The raw materials used in this example are shown in Table 1.

[0045] Table 1

[0046]

[0047]

[0048] Example 2

[0049] The present invention provides a method for preparing a supramolecular bosine composition having multi-target anti-aging effects on skin, the preparation method comprising the following steps:

[0050] (1) Pre-dosing process: accurately weigh hydroxypropyl tetrahydropyrantriol, rhamnose, lactic acid, betaine, vitamin E, and purified water, put them into a water pot, heat to 75° C., and stir and dissolve for 10 minutes to obtain phase A;

[0051] (2) Blending process: accurately weigh dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, coconut oil alcohol monocaprylate / caprate, glyceryl stearate, and caprylyl glycol, put them into an oil pan, heat to 80° C. and stir homogenously for 30 minutes to dissolve, to obtain phase B;

[0052] Mix phase A and phase B, homogenize and emulsify for 10 minutes until the system is uniform, then stir and keep warm for 20 minutes, and stir and cool to 60°C to obtain a blending phase;

[0053] (3) Synergistic process: maintaining the temperature at 60°C, adding Alpinia galanga leaf extract, acetyl hexapeptide-8, soluble collagen, sodium hyaluronate cross-linked polymer, and purified water to the blending phase, stirring at 25 rpm for 20 min until the system is uniform and cooling to 35°C; then degassing and filtering in sequence, aging the semi-finished product at room temperature for 20 h after passing the inspection, to obtain the supramolecular bosin composition with multi-target anti-aging effects on the skin.

[0054] The raw materials used in this example are shown in Table 2.

[0055] Table 2

[0056]

[0057]

[0058] Example 3

[0059] The present invention provides a method for preparing a supramolecular bosine composition having multi-target anti-aging effects on skin, the preparation method comprising the following steps:

[0060] (1) Pre-dosing process: accurately weigh hydroxypropyl tetrahydropyrantriol, rhamnose, lactic acid, betaine, vitamin E, and purified water, put them into a water pot, heat to 77° C., and stir and dissolve them for 12 minutes to obtain phase A;

[0061] (2) Blending process: accurately weigh dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, coconut oil alcohol monocaprylate / caprate, glyceryl stearate, and caprylyl glycol, put them into an oil pan, heat to 77° C. and stir homogenously for 45 minutes to dissolve, to obtain phase B;

[0062] Mix phase A and phase B, homogenize and emulsify for 8 minutes until the system is uniform, then stir and keep warm for 15 minutes, and stir and cool to 55°C to obtain a blending phase;

[0063] (3) Synergistic process: maintaining the temperature at 55°C, adding Alpinia galanga leaf extract, acetyl hexapeptide-8, soluble collagen, sodium hyaluronate cross-linked polymer, and purified water to the blending phase, stirring at 25 rpm for 17 minutes until the system is uniform and cooling to 32°C; then degassing and filtering in sequence, aging the semi-finished product at room temperature for 17 hours after the semi-finished product is tested and qualified, thereby obtaining the supramolecular bosin composition with multi-target anti-aging effects on the skin.

[0064] The raw materials used in this example are shown in Table 3.

[0065] Table 3

[0066]

[0067]

[0068] Comparative Example 1

[0069] The difference between this comparative example and Example 3 is that lactic acid (organic acid) and hydroxyproline (amino acid) are not added in this comparative example, and other operations are the same as Example 3.

[0070] Comparative Example 2

[0071] The difference between this comparative example and Example 3 is that lactic acid (organic acid) is not added in this comparative example, and other operations are the same as Example 3.

[0072] Comparative Example 3

[0073] The difference between this comparative example and Example 3 is that hydroxyproline (amino acid) is not added in this comparative example, and other operations are the same as those in Example 3.

[0074] Test Example 1

[0075] Figure 1 It is a statistical chart of the skin penetration of products with different components. It can be seen from the figure that the cumulative penetration of the supramolecular Bose-like composition of the present invention (obtained in Example 3) at 6h, 22h, 23h, and 24h is significantly greater than that of the control group, which shows that the product of the present invention has a high efficiency in promoting penetration and absorption, and has good activity and bioavailability.

[0076] in, Figure 1 The "bosine + organic acid + amino acid" group was used as the experimental group, and the corresponding product was obtained as Example 3.

[0077] Figure 1 The "Bose" group is used as the first control group, and the corresponding product is obtained from Comparative Example 1.

[0078] Figure 1 The "Bosone + amino acid" group is used as the second control group, and the corresponding product is obtained from Comparative Example 2.

[0079] Figure 1 The "bosine + organic acid" group is used as the third control group, and the corresponding product is obtained from Comparative Example 3.

[0080] Test Example 2

[0081] 1. Test samples

[0082] Test substances: the supramolecular Bossagra composition with multi-target anti-aging effects on skin obtained in Example 3; and commercially available ordinary Bossagra products.

[0083] Control: Control with ordinary Bossagra products on the market, before and after control;

[0084] How to use: After cleansing, apply an appropriate amount of this product on the face and neck, and pat gently until absorbed;

[0085] Test area: forehead, cheeks.

[0086] 2. Test Purpose

[0087] Recruit at least 31 subjects with sensitive skin to check the changes in skin elasticity R2 value, skin elasticity R5 value, skin wrinkle area, and skin wrinkle depth before and after using the test samples to verify the firming and anti-wrinkle effects of the test samples.

[0088] 3. Test method basis

[0089] Method: Instrumental analysis;

[0090] T / ZHCA006-2019 Test method for anti-wrinkle efficacy of cosmetics;

[0091] T / GDCDCC-020-2022 Test method for firming effect of cosmetics.

[0092] 4. Test equipment

[0093] 4.1. Skin elasticity tester MPA580, Courage+Khazaka skin elasticity tester;

[0094] 4.2.Canfieldsci skin rapid optical imaging system PRIMOS;

[0095] 4.3. Analytical balance.

[0096] 5. Test indicators

[0097] 5.1. Efficacy test, as shown in Table 4.

[0098] Table 4

[0099]

[0100] 6. Statistics

[0101] The statistical analysis software SPSS was used to perform statistical analysis of the data and calculate the mean, standard deviation and change rate of each parameter at each time point.

[0102] Calculation formula:

[0103] Change rate = [(value after use - value before use) / value before use] × 100%

[0104] Normal distribution test

[0105] The above means were tested for normal distribution. If the asymptotic significance (two-sided) value of the normality test was > 0.050, then the data series followed a normal distribution.

[0106] Difference Analysis

[0107] (i) Comparison before and after using samples: Perform difference analysis on the above means. When the two groups of data are normally distributed at the same time, use paired T test analysis;

[0108] The difference between two groups of data; when the two groups of data are not normally distributed at the same time, the rank sum test is used to analyze the difference between the two groups of data.

[0109] (ii) Analysis of subjects’ self-assessment results: The binomial distribution method was used for statistical analysis. The expected value of the degree of recognition was set at 60% (the proportion of people with a score of ≥4 points). The 95% confidence interval was used to test the statistical significance of the survey questions.

[0110] Judging Criteria

[0111] “ns” indicates no statistical difference, P>0.05; “*” indicates significant difference, 0.01≤P<0.05; “**” indicates very significant difference, 0.001≤P<0.01; “***” indicates extremely significant difference, P<0.001.

[0112] 7. Test process: as shown in Table 5.

[0113] Table 5

[0114]

[0115]

[0116] 8. Test results

[0117] 8.1 Skin elasticity R2 value: as shown in Table 6, the corresponding data is as follows Figure 2 shown.

[0118] Table 6

[0119]

[0120] Parameter description: The larger the measurement value, the better the skin elasticity;

[0121] Result interpretation: Compared with before using the samples, the skin elasticity R2 values ​​of 31 subjects showed significant differences after using the samples for 14 days, and the rate of change was greater than that of ordinary Bossagra products currently available on the market.

[0122] It shows that the test sample has a firming effect after 14 days of use.

[0123] 8.2 Skin elasticity R5 value: As shown in Table 7, the corresponding data is Figure 3 shown.

[0124] Table 7

[0125]

[0126] Parameter description: The larger the measurement value, the better the skin elasticity;

[0127] Result interpretation: Compared with before using the samples, the skin elasticity R5 values ​​of 31 subjects showed significant differences after using the samples for 14 days, and the rate of change was greater than that of ordinary Bossagra products currently available on the market.

[0128] It shows that the test sample has a firming effect after 14 days of use.

[0129] 8.3 Skin wrinkle area (eye corner): As shown in Table 8, the corresponding data is Figure 4 shown.

[0130] Table 8

[0131]

[0132]

[0133] Parameter description: The smaller the measured value, the smaller the skin wrinkle area;

[0134] Result interpretation: Compared with before using the samples, the 31 subjects had significant differences in skin wrinkle area (corners of the eyes) after using the samples for 14 days, and the rate of change was greater than that of ordinary Bose-based products currently available on the market.

[0135] It shows that the test sample has anti-wrinkle effect after 14 days of use.

[0136] 8.4 Changes in skin wrinkle depth: As shown in Table 9, the corresponding photos are Figure 5 , Figure 6 shown.

[0137] In order to make a direct comparison, subject No. 09 and subject No. 13 were selected to take photos of crow's feet for comparison, as shown in Table 9. Figure 5 , Figure 6 , Figure 7 , Figure 8 shown.

[0138] Table 9

[0139]

[0140] Result interpretation: After 14 days, the crow's feet of subject No. 09 became significantly lighter.

[0141] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A supramolecular bosine composition with multi-target anti-aging effects on skin, characterized in that: It consists of phase A, phase B and phase C; among which: The phase A is composed of the following raw materials in parts by weight: 10-20 parts of hydroxypropyl tetrahydropyrantriol, 1-5 parts of rhamnose, 0.5-2 parts of hydroxyproline, 1-6 parts of lactic acid, 1-10 parts of betaine, 0.5-5 parts of vitamin E, and 10-30 parts of purified water; The phase B is composed of the following raw materials in parts by weight: 2 to 10 parts of polydimethylsiloxane, 0.5 to 5 parts of lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 0.5 to 5 parts of coconut oil alcohol-caprylate / caprate, 1 to 3 parts of glyceryl stearate, and 0.1 to 1 part of caprylyl glycol; The phase C is composed of the following raw materials in parts by weight: 1-5 parts of Alpinia galanga leaf extract, 0.001-0.5 parts of acetyl hexapeptide-8, 0.01-2 parts of soluble collagen, 0.01-2 parts of sodium hyaluronate cross-linked polymer, and 30-55 parts of purified water.

2. The supramolecular bosine composition with multi-target anti-aging effects on skin according to claim 1, characterized in that: The phase A is composed of the following raw materials in parts by weight: 15 parts of hydroxypropyl tetrahydropyrantriol, 3 parts of rhamnose, 1.5 parts of hydroxyproline, 3.5 parts of lactic acid, 5.5 parts of betaine, 2.5 parts of vitamin E, and 20 parts of purified water; The phase B is composed of the following raw materials in parts by weight: 6 parts of polydimethylsiloxane, 2.5 parts of lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 2.5 parts of coconut oil alcohol-caprylate / caprate, 2 parts of glyceryl stearate, and 0.5 parts of caprylyl glycol; The phase C is composed of the following raw materials in parts by weight: 3 parts of Alpinia galanga leaf extract, 0.25 parts of acetyl hexapeptide-8, 1 part of soluble collagen, 1 part of sodium hyaluronate cross-linked polymer, and 45 parts of purified water.

3. The method for preparing the supramolecular bosine composition having multi-target anti-aging effects on skin according to claim 1 or 2, characterized in that: The preparation method comprises: (1) Pre-dosing process: accurately weigh hydroxypropyl tetrahydropyrantriol, rhamnose, hydroxyproline, lactic acid, betaine, vitamin E, and purified water, put them into a reactor, heat them, and stir and dissolve them to obtain phase A; (2) Blending process: accurately weigh dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, coconut oil alcohol monocaprylate / caprate, glyceryl stearate, and caprylyl glycol and put them into another reactor, heat and stir to dissolve, and obtain phase B; Mix phase A and phase B, homogenize and emulsify until the system is uniform, then stir and keep warm, stir and cool in sequence to obtain a blending phase; (3) Synergistic process: maintaining the temperature, adding Alpinia galanga leaf extract, acetyl hexapeptide-8, soluble collagen, sodium hyaluronate cross-linked polymer, and purified water to the blending phase, stirring at high speed until the system is uniform and cooling; then degassing, filtering, testing, and aging in sequence to obtain the supramolecular bosin composition with multi-target anti-aging effects on the skin.

4. The method for preparing the supramolecular bosine composition having multi-target anti-aging effects on skin according to claim 3, characterized in that: In step (1), the temperature is raised to 70-75° C., and the homogenizing stirring time is 10-15 minutes.

5. The method for preparing the supramolecular bosine composition having multi-target anti-aging effects on skin according to claim 3, characterized in that: In step (2), the temperature is raised to 75-80° C., and the homogenizing stirring time is 30-60 min.

6. The method for preparing the supramolecular bosine composition with multi-target anti-aging effects on skin according to claim 3, characterized in that: In step (2), the homogenization and emulsification time is 5 to 10 minutes, the stirring and heat preservation time is 10 to 20 minutes, and the stirring and cooling to 50 to 60°C are performed.

7. The method for preparing the supramolecular bosine composition with multi-target anti-aging effects on skin according to claim 3, characterized in that: In step (3), the temperature is maintained at 50-60° C., the speed of high-speed stirring is 25 rpm, and the time of high-speed stirring is 15-20 min.

8. The method for preparing the supramolecular bosine composition with multi-target anti-aging effects on skin according to claim 3, characterized in that: In step (3), the aging time is 15 to 20 hours.

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