A method for drying and curing microspheres

Abstract

The present invention relates to the technical field of microsphere manufacturing, and specifically to a microsphere drying, curing and molding method, which includes a first washing and filtering process, wherein the microspheres are input into a reactor, a washing liquid is added for stirring and washing, and then the microspheres smaller than a preset particle size are filtered out; a first drying process, wherein the microsphere material in the reactor is blown and dried, and the reactor is evacuated during the process to ensure that the air pressure in the reactor is within a preset interval until the moisture content of the microsphere material is lower than a preset value; a second washing and filtering process, wherein the washing liquid is added to the reactor for stirring and washing, and then the impurities smaller than a preset particle size are filtered out; a second drying process, wherein the wet microsphere material in the reactor is freeze-dried until the moisture content of the material is lower than a preset value. The method is suitable for batch preparation of microsphere products in the pharmaceutical industry.

Description

[0001] This application is a divisional application. The application date of the original application is December 29, 2023. The application number is 2023118462983. The name of the invention is: A microsphere drying and curing molding device. Technical Field

[0002] The invention relates to the technical field of microsphere manufacturing, and in particular to a microsphere drying, curing and molding method. Background Art

[0003] The solidification preparation of microsphere materials requires filtering out microspheres with smaller particle sizes from the microspheres, and then drying and solidifying them to ensure that the particle size of the prepared microspheres meets the requirements. In a laboratory environment, due to the small amount of material, small particle size impurities in the microsphere solution can be filtered out by flushing and filtration. However, in the preparation of large quantities of microsphere solid materials, since the microsphere materials are in a piled state after filtration, it is difficult to ensure the uniformity of flushing by simple flushing and filtration, and it is impossible to effectively filter out impurities with smaller particle sizes. Summary of the invention

[0004] In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides a microsphere drying and curing molding method, which can realize the composite drying and curing process and ensure the quality of microsphere curing molding, and is suitable for batch preparation of microsphere solid materials in the pharmaceutical industry.

[0005] In order to achieve the above object, the present invention is implemented through the following technical solutions:

[0006] A microsphere drying and solidification molding method is used to dry and solidify a microsphere solution into a microsphere dry powder, comprising the following steps:

[0007] Step S1, washing and filtering once, inputting the microspheres into a reactor, adding washing liquid for washing, and filtering out impurities smaller than a preset particle size;

[0008] Step S2, primary drying, blowing and drying the microsphere material in the reactor until the moisture content of the microsphere material is lower than a preset value, during which the reactor is evacuated to ensure that the air pressure in the reactor is within a preset range; the blowing medium is nitrogen, and the moisture content of the microsphere material is required to be lower than 2% after primary drying;

[0009] Step S3, secondary washing and filtering, adding washing liquid to the reactor for washing, filtering out impurities smaller than a preset particle size; in step S1 and step S3, the impurities filtered out have a particle size of less than 15 microns;

[0010] Step S4, injecting liquid, adding a preset dose of water for injection; the dose of water for injection is based on just covering the microsphere material;

[0011] Step S5, secondary drying, freeze-drying the microsphere material in the reactor until the moisture content is less than 1%;

[0012] The microsphere drying and curing molding device used comprises a reaction kettle, wherein the reaction kettle comprises a cylinder and a cover, wherein the cover sealing cover is arranged on the cylinder, and the reaction kettle is provided with:

[0013] A filter device, including a filter basket;

[0014] An air pressure control unit, comprising an air intake unit and an air extraction unit, for controlling the air pressure in the reactor;

[0015] The air inlet portion includes an air inlet disposed below the filter basket, which can blow air to dry the material in the filter basket;

[0016] The heat exchange part is used to control the temperature in the reactor;

[0017] The drying processes that can be realized include freeze drying, vacuum drying and air blowing drying;

[0018] The air extraction part comprises an air extraction port arranged above the filter basket;

[0019] The reactor is provided with an insulation shell on the outside, the heat exchange part is a heat exchange cavity arranged on the inside of the insulation shell, the heat exchange cavity is coated on the outside of the reactor inner cavity wall shell, the heat exchange cavity includes vertically stacked compartments, and the adjacent compartments are connected to each other;

[0020] The top of the filter basket is provided with an annular positioning plate extending radially outward, the filter basket is detachably mounted on the cylinder through the annular positioning plate, and a gap is provided between the side wall of the filter basket and the inner wall of the cylinder;

[0021] An air collecting hood is provided at the bottom of the inner cavity of the cylinder, the air collecting hood is arranged at the bottom of the filter basket, a sealing ring is provided between the bottom of the filter basket and the air collecting hood, the air inlet is provided on the air collecting hood, a liquid outlet cavity is provided between the bottom of the air collecting hood and the bottom of the cylinder, a liquid outlet hole is provided at the bottom of the cylinder, and the liquid outlet hole is communicated with the liquid outlet cavity;

[0022] It also includes a pipeline integrated plate, which is arranged outside the reactor, the pipeline integrated plate and the reactor are fixedly connected via a connecting shaft, and the pipeline integrated plate is provided with a group of first rigid pipe bodies, which are connected to the gas and liquid inlets and outlets connected to the various pipelines on the reactor;

[0023] It also includes a pipeline external connection plate, which is fixedly arranged on the outside of the pipeline integrated plate away from the reactor, and a group of second rigid pipe bodies are arranged on the pipeline external connection plate, the first rigid pipe body and the second rigid pipe body correspond to each other one by one, and the first rigid pipe body and the second rigid pipe body are connected by a hose;

[0024] It also includes a vibration generating part, which includes an air hammer. The air hammer is installed on the reactor. The striking head of the air hammer extends into the outer side of the inner wall of the reactor corresponding to the filter basket. A pad is provided between the filter basket and the inner wall of the reactor corresponding to the position of the air hammer striking head.

[0025] It can be seen from the above technical solution that the present invention has the following beneficial effects:

[0026] The present invention provides a microsphere drying and solidification molding method, which can ensure that impurities in microsphere materials are fully filtered through one washing and filtering, one drying, and two washing and filtering. In the process of one drying, the air pressure in the reactor is ensured to be within a preset range through synchronous air extraction, which can prevent the molecular structure from being damaged by the influence of environmental pressure during microsphere molding. The integrity of the performance of the obtained microsphere dry powder can be ensured through the second drying, thereby ensuring the quality of microsphere solidification molding, and is suitable for batch preparation of microsphere solid materials in the pharmaceutical industry. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 A schematic diagram of the three-dimensional structure of a microsphere drying and curing molding device described in an embodiment of the present application;

[0028] Figure 2 This is a schematic diagram of the internal structure of the reactor described in the embodiment of the present application;

[0029] Figure 3 for Figure 2 A partial enlarged view of the area B in the middle circle;

[0030] Figure 4 A schematic diagram of a vibration generating unit according to an embodiment of the present application;

[0031] Figure 5 for Figure 4 A partial enlarged view of the area A in the middle circle;

[0032] Figure 6 This is a schematic diagram of the air outlet plate described in an embodiment of the present application.

[0033] In the figure: 1-reactor; 11-cylinder; 111-air inlet; 112-liquid outlet chamber; 113-liquid outlet hole; 12-cover; 121-feeding port; 122-exhaust port; 13-driving shaft; 14-connecting shaft; 15-gas collecting hood; 16-sealing ring; 17-air outlet plate; 171-air outlet hole; 18-insulating shell; 19-heat exchange chamber; 191-compartment chamber; 192-liquid inlet; 193-liquid outlet; 2-filter basket; 21-annular positioning plate; 3-stirring paddle; 4-swinging drive device; 5-pipeline integrated disk; 51-first rigid tube body; 6-pipeline external connection disk; 61-second rigid tube body; 7-seat; 8-vibration generating part; 81-air hammer; 82-pad. DETAILED DESCRIPTION

[0034] Example 1

[0035] The solidification preparation of microsphere materials requires filtering out microspheres with smaller particle sizes from the microspheres, and then drying and solidifying them to ensure that the particle size of the prepared microspheres meets the requirements. In a laboratory environment, due to the small amount of material, small-sized impurities in the microsphere solution can be filtered out by flushing and filtration. However, in the preparation of large quantities of microsphere solid materials, since the microsphere materials are in a piled state after filtration, it is difficult to ensure the uniformity of flushing by simple flushing and filtration, and it is impossible to effectively filter out impurities with smaller particle sizes. In this regard, a microsphere drying and solidification molding process is proposed, which is used to dry and solidify the microsphere solution into a microsphere dry powder, comprising the following steps:

[0036] Step S1, washing and filtering once, inputting the microspheres into a reactor, adding washing liquid for washing, and filtering out impurities smaller than a preset particle size;

[0037] Step S2, primary drying, blowing and drying the microsphere material in the reactor until the moisture content of the microsphere material is lower than a preset value. During this process, the reactor is evacuated to ensure that the air pressure in the reactor is within a preset range; specifically, the blowing medium is nitrogen, and the moisture content of the microsphere material is required to be lower than 2% after primary drying.

[0038] Step S3, secondary washing and filtration, adding washing liquid to the reactor for washing, filtering out impurities smaller than a preset particle size; in this embodiment, in step S1 and step S3, the particle size of the impurities filtered out is less than 15 microns.

[0039] Step S4, injecting liquid, adding a preset dose of water for injection; specifically, the dose of the water for injection is based on just covering the microsphere material.

[0040] Step S5, secondary drying, freeze-drying the microsphere material in the reactor until the water content is lower than a preset value. Specifically, the water content of the microsphere dry powder obtained after secondary drying is required to be lower than 1%.

[0041] Based on the above method, the principle of the microsphere drying and curing molding device is: through one washing and filtering, one drying, and two washing and filtering, it can ensure that the impurities in the microsphere material are fully filtered. In the process of one drying, by synchronously pumping air, the air pressure in the reactor is guaranteed to be in the preset range, which can prevent the molecular structure from being damaged by the environmental pressure during microsphere molding. The integrity of the performance of the obtained microsphere dry powder can be guaranteed through secondary drying, thereby ensuring the quality of microsphere curing molding. It is suitable for batch preparation of microsphere solid materials in the pharmaceutical industry.

[0042] In this embodiment, in step S2, the blowing port is arranged at the bottom of the reaction kettle corresponding to the position of the microsphere material, and the exhaust port is arranged at the top of the reaction kettle.

[0043] Blowing at the bottom and exhausting at the top can form convection energy to ensure the stability of air pressure.

[0044] In this embodiment, in step S2, the air pressure range in the reactor is [10Pa, 1bar).

[0045] If the air pressure in the reactor exceeds the above pressure range, the microspheres will be damaged.

[0046] In this embodiment, step S5 includes the following steps:

[0047] Step S5.1: Cooling down: after a preset time, the temperature in the reactor is reduced to a first preset value; specifically, the first preset value is -30°C, and the cooling time is 0.5h.

[0048] Step S5.2: pre-freezing, maintaining the temperature in the reactor at a first preset value within a preset time; specifically, the pre-freezing time is 4 hours.

[0049] Step S5.3: Evacuate the reactor to maintain the pressure at a second preset value by continuous evacuation; specifically, the second preset value is 10Pa.

[0050] Step S5.4: Drying. When the pressure of the reactor is maintained at the second preset value, the reactor is heated up in stages, and the temperature of each stage is maintained for a preset time until the temperature reaches the third preset value. Specifically, there are 5 heating stages, and the temperatures of each stage are -15°C, -5°C, 5°C, 25°C, and 48°C. The third preset value is 48°C. The heating time of each stage is 2h, and the temperature maintenance time of each stage is 6h, 6h, 10h, 10h, and 4h respectively.

[0051] Under the continuous vacuum environment, the staged heating can ensure that the microsphere material is fully dried and the performance is intact.

[0052] Example 2

[0053] Combination Figures 1 to 6 The microsphere drying and curing molding device can realize the microsphere drying and curing molding process described in Example 1, comprising: a reaction kettle 1, wherein the reaction kettle 1 is provided with:

[0054] A filtering device, comprising a filter basket 2;

[0055] An air pressure control unit, comprising an air intake unit and an air extraction unit, for controlling the air pressure in the reactor 1;

[0056] The air inlet portion includes an air inlet 111 disposed below the filter basket 2, which can blow air to dry the material in the filter basket 2;

[0057] The heat exchange part is used to control the temperature in the reactor 1. In this embodiment, the air extraction part includes an air extraction port 122 arranged above the filter basket 2. The drying processes that can be realized include freeze drying, vacuum drying and air blowing drying.

[0058] Based on the above device, when freeze drying is performed, the heat exchange part cools down the reactor. When vacuum drying is performed, the air pressure control part performs a vacuum operation on the reactor. During the drying process, water vapor evaporates through the air pressure control part to ensure the balance of air pressure in the reactor. The air pressure control part can adjust the positive and negative pressures of the air pressure in the reactor. The air intake part intakes air to adjust the positive pressure; the air extraction part extracts air to adjust the negative pressure. During the process of blowing drying at the air inlet, the air intake and air extraction of the air inlet and the air extraction part are balanced to achieve the balance of air pressure in the reactor during the drying process. In this embodiment, the air inlet 111 is used as an air blowing port to perform blowing drying and as a liquid discharge port to discharge washing solution and impurities. Since the liquid discharge and air blowing are performed in two independent steps, it is only necessary to switch the pipeline connected to the air inlet 111 to achieve the switching of the liquid discharge and air blowing functions. It has the advantage of high integration. The filter basket 2 is used to receive the microsphere material entering the reactor 1 and filter it. Specifically, the aperture of the filter basket can be changed according to the particle size requirements of different microspheres.

[0059] A microsphere drying and curing molding method based on the above device includes the following steps:

[0060] Step S1, washing process, inputting the microspheres into the reactor, adding washing liquid, rinsing and / or soaking washing, and at the same time, the temperature of the washing process can be controlled within a preset range through a heat exchange device;

[0061] Step S2, filtering process, filtering out excess detergent and microspheres smaller than a preset particle size through the filter basket;

[0062] Step S3, a drying process, dries the microsphere material in the reactor. According to the characteristics of different microsphere materials, one or more drying processes such as freeze drying, vacuum drying, and air blowing drying are selected to achieve a moisture content of the microspheres below a preset value.

[0063] In this embodiment, the reactor 1 includes a cylinder 11 and a cover 12, the cover 12 is sealed on the cylinder 11, and a feed port 121 and a gas extraction port 122 are provided on the cover 12; based on the above device, the cover 12 is sealed and connected to the cylinder 11 to ensure that the air pressure in the reactor 1 is controllable, and the feed port 121 is used to input the microsphere solution and the washing liquid.

[0064] In this embodiment, a stirring paddle 3 is also included. The stirring paddle 3 is rotatably mounted on the cover body 12, and the blades of the stirring paddle 3 are arranged in the filter basket 2. When performing the washing and filtering steps, the stirring paddle 3 is used to stir the material to improve the uniformity of washing.

[0065] In this embodiment, a swing drive device 4 is also included, and the swing drive device 4 is connected to the reactor 1 in a transmission manner. The swing drive device 4 is used to drive the reactor 1 to swing back and forth as a whole within a preset angle. The swing drive device 4 is used to drive the reactor 1 to swing during the washing and filtering step, so that the material is fully washed and filtered. Specifically, the swing angle is ±60°. In this embodiment, the swing drive device 4 is a motor, and a drive shaft 13 is fixed to the reactor 1. The drive shaft 13 is connected to the swing drive device 4 in a transmission manner, and the motor drives the drive shaft 13 to rotate in a forward and reverse direction to achieve the swing of the reactor 1.

[0066] In this embodiment, a pipeline integrated disk 5 is further included, and the pipeline integrated disk 5 is arranged outside the reactor 1. The pipeline integrated disk 5 and the reactor 1 are fixedly connected via a connecting shaft 14. The pipeline integrated disk 5 is provided with a group of first rigid pipe bodies 51, and the group of first rigid pipe bodies 51 is connected to the gas and liquid inlet and outlet of each pipeline connection on the reactor 1;

[0067] It also includes a pipeline external connection plate 6, which is fixedly arranged on the outer side of the pipeline integrated plate 5 away from the reactor 1. A group of second rigid tube bodies 61 are arranged on the pipeline external connection plate 6. The first rigid tube body 51 and the second rigid tube body 61 correspond to each other one by one, and the first rigid tube body 51 and the second rigid tube body 61 are connected by a hose. When the reactor 1 rotates, the pipeline integrated plate 5 is driven to rotate synchronously, and the pipeline external connection plate 6 is stationary. Through the above device, when the reactor 1 is swung by the swing drive device 4, it is prevented that the tube bodies connected to the reactor 1 are separated or rubbed against each other and damaged.

[0068] In this embodiment, a pair of seats 7 are provided on both sides of the reactor 1, the driving shaft 13 and the connecting shaft 14 are rotatably mounted on the pair of seats 7, the pipeline external plate 6 is fixed on the seat 7 near the side of the connecting shaft 14, and the swing drive device 4 is arranged on the seat 7 near the side of the driving shaft 13. The seat 7 is provided to support the reactor 1, corresponding to the installation position of the driving shaft 13 and the connecting shaft 14, and a bearing seat is provided on the seat 7 to ensure the stability of the swinging motion of the reactor 1.

[0069] Combination Figure 4 As shown, in this embodiment, the top of the filter basket 2 is provided with an annular positioning plate 21 extending radially outward, and the filter basket 2 is detachably mounted on the barrel 11 through the annular positioning plate 21, and a gap is provided between the side wall of the filter basket 2 and the inner wall of the barrel 11. Through the annular positioning plate 21, the filter basket 2 is hung on the barrel 11 as a whole, and a gap is provided between the inner wall of the barrel 11 to ensure that the washing liquid can flow out of the side wall during filtration, thereby improving the filtration efficiency. It should be noted that the annular positioning plate 21 and the barrel 11 need to be relatively locked at least radially and axially. In this embodiment, the size of the gap is 2.5mm. Specifically, the annular positioning plate 21 can be locked on the barrel 11 by providing a slot adapted to the shape of the annular positioning plate 21 or by providing a connecting piece (screw). It should be noted that if a slot is provided, the annular positioning plate 21 needs to be pressed into the slot of the barrel 11 through the cover 12 to achieve axial locking of the annular positioning plate 21.

[0070] Combination Figure 3As shown, in this embodiment, an air collecting hood 15 is provided at the bottom of the inner cavity of the cylinder 11, and the air collecting hood 15 is provided at the bottom of the filter basket 2. A sealing ring 16 is provided between the bottom of the filter basket 2 and the air collecting hood 15. The air inlet 111 is provided on the air collecting hood 15. A liquid outlet cavity 112 is provided between the bottom of the air collecting hood 15 and the bottom of the cylinder 11. A liquid outlet hole 113 is provided at the bottom of the cylinder 11, and the liquid outlet hole 113 is communicated with the liquid outlet cavity 112. Since the material is accumulated at the bottom of the filter basket 2, when the bottom of the filter basket 2 is blown, when the material blocks the bottom of the filter basket 2, the airflow will enter the filter basket 2 from the side wall of the filter basket 2 above the material accumulation, resulting in the blown airflow being unable to fully contact the material, affecting the blowing and drying effect. By setting up the air collecting hood 15 and sealingly connecting the air collecting hood 15 with the bottom of the filter basket 2 through the sealing ring 16, the air inlet 111 is set on the air collecting hood 15, so the air inlet channel of the air inlet 111 is isolated from the side wall of the filter basket 2 by the air collecting hood 15. In this case, when blowing, the airflow can only pass through the filter basket 2 from the bottom of the filter basket 2, which can ensure that the airflow is fully in contact with the material and improve the blowing and drying effect. When discharging liquid, the solution discharged from the side wall of the filter basket 2 flows from the gap between the side wall of the filter basket 2 and the cylinder 11 to the liquid outlet cavity 112 and then discharged from the liquid outlet hole 113, and the solution discharged from the bottom of the filter basket 2 is still discharged from the air inlet 111. In this embodiment, the pipeline corresponding to the air inlet 111 is penetrated in the liquid outlet hole 113, that is, the liquid outlet hole 113 is annular. The air collecting hood 15 is welded to the bottom of the cylinder 11 through a support member (not shown) circumferentially arranged at the bottom of the air collecting hood 15.

[0071] During the air drying process, the air flow will be concentrated in the upper end area of ​​the air inlet 111 for blowing, making it difficult for materials in other areas of the filter basket 2 to contact with the air flow, thereby affecting the uniformity of the air drying. Figure 6 As shown, in this embodiment, the air collecting cover 15 is provided with an air outlet plate 17, and the air outlet plate 17 is arranged below the filter basket 2. The air outlet plate 17 is provided with a group of air outlet holes 171, and the air outlet holes 171 are arranged in a radially divergent array corresponding to the center of the bottom of the filter basket 2. Specifically, the air outlet plate 17 is circular and adapted to the bottom of the filter basket 2. The air outlet holes 171 correspond to the center of the circle, and radially diverge from the center to form 5 groups, each group having 4 holes in the circumferential direction. Therefore, the uniformity of air blowing and drying can be improved.

[0072] Combination Figure 2As shown, in this embodiment, an insulation shell 18 is provided on the outside of the reactor 1, and a heat exchange chamber 19 is provided on the inside of the insulation shell 18. The heat exchange chamber 19 is coated on the outside of the inner chamber wall shell of the reactor 1. The heat exchange chamber 19 includes compartments 191 stacked in the vertical direction, and the adjacent compartments 191 are interconnected. The heat exchange chamber 19 is used to pass heat exchange medium to control the temperature in the reactor 1. The heat exchange chamber 19 is divided into a group of compartments 191 by arranging a partition in the heat exchange chamber 19. The compartments 191 are in the shape of a ring column, which can ensure the uniformity of heat transfer. In this embodiment, a liquid inlet 192 is provided at the bottom of the heat exchange chamber 19, and a liquid outlet 193 is provided at the top of the heat exchange chamber 19. The heat exchange medium is silicone oil.

[0073] A cold trap (not shown) is provided between the air extraction port 122 and the air extraction pump (not shown), and the cold trap is used to condense the moisture in the extracted gas to prevent the moisture from entering the air extraction pump and causing the air extraction pump to rust and be damaged. Specifically, the operating temperature of the cold trap is -40°C.

[0074] Combination Figure 4 As shown, it also includes a vibration generating unit 8, and the vibration generating unit 8 includes an air hammer 81, and the air hammer 81 is installed on the reactor 1. The striking head of the air hammer 81 extends into the outer side of the inner wall of the reactor 1 corresponding to the storage filter basket 2, and a cushion block 82 is provided between the filter basket 2 and the inner wall of the reactor 1 corresponding to the position of the striking head of the air hammer 81. In the filtering, washing and drying stages, the air hammer 81 is used to strike the inner cavity shell of the reactor 1, and transmit the vibration to the filter basket 2 through the cushion block 82, thereby assisting the fine particle size microspheres to fall out of the sieve holes of the filter basket 2, achieving full filtration to shorten the filtration time, improve the filtration efficiency, and assist in shaking off the standard particle size microspheres adhering to the side of the filter basket 2 when discharging, thereby improving the collection efficiency.

[0075] The technical principles of the present invention are described above in conjunction with specific embodiments. These descriptions are only for explaining the principles of the present invention and cannot be interpreted as limiting the scope of protection of the present invention in any way. Based on the explanations herein, those skilled in the art can associate other specific implementations of the present invention without creative work, and these methods will fall within the scope of protection of the present invention.

Claims

1. A microsphere drying and curing molding method, characterized in that: The method is used to dry and solidify the microsphere solution into microsphere dry powder, comprising the following steps: Step S1, washing and filtering once, inputting the microspheres into a reactor, adding washing liquid for washing, and filtering out impurities smaller than a preset particle size; Step S2, primary drying, blowing and drying the microsphere material in the reactor until the moisture content of the microsphere material is lower than a preset value, during which the reactor is evacuated to ensure that the air pressure in the reactor is within a preset range; the blowing medium is nitrogen, and the moisture content of the microsphere material is required to be lower than 2% after primary drying; Step S3, secondary washing and filtering, adding washing liquid to the reactor for washing, filtering out impurities smaller than a preset particle size; in step S1 and step S3, the impurities filtered out have a particle size of less than 15 microns; Step S4, injecting liquid, adding a preset dose of water for injection; the dose of water for injection is based on just covering the microsphere material; Step S5, secondary drying, freeze-drying the microsphere material in the reactor until the moisture content is less than 1%; The microsphere drying and curing molding device used comprises a reaction kettle, wherein the reaction kettle comprises a cylinder and a cover, wherein the cover sealing cover is arranged on the cylinder, and the reaction kettle is provided with: A filter device, including a filter basket; An air pressure control unit, comprising an air intake unit and an air extraction unit, for controlling the air pressure in the reactor; The air inlet portion includes an air inlet disposed below the filter basket, which can blow air to dry the material in the filter basket; The heat exchange part is used to control the temperature in the reactor; The drying processes that can be realized include freeze drying, vacuum drying and air blowing drying; The air extraction part comprises an air extraction port arranged above the filter basket; The reactor is provided with an insulation shell on the outside, the heat exchange part is a heat exchange cavity arranged on the inside of the insulation shell, the heat exchange cavity is coated on the outside of the reactor inner cavity wall shell, the heat exchange cavity includes vertically stacked compartments, and the adjacent compartments are connected to each other; The top of the filter basket is provided with an annular positioning plate extending radially outward, the filter basket is detachably mounted on the cylinder through the annular positioning plate, and a gap is provided between the side wall of the filter basket and the inner wall of the cylinder; An air collecting hood is provided at the bottom of the inner cavity of the cylinder, the air collecting hood is arranged at the bottom of the filter basket, a sealing ring is provided between the bottom of the filter basket and the air collecting hood, the air inlet is provided on the air collecting hood, a liquid outlet cavity is provided between the bottom of the air collecting hood and the bottom of the cylinder, a liquid outlet hole is provided at the bottom of the cylinder, and the liquid outlet hole is communicated with the liquid outlet cavity; It also includes a pipeline integrated plate, which is arranged outside the reactor, the pipeline integrated plate and the reactor are fixedly connected via a connecting shaft, and the pipeline integrated plate is provided with a group of first rigid pipe bodies, which are connected to the gas and liquid inlets and outlets connected to the various pipelines on the reactor; It also includes a pipeline external connection plate, which is fixedly arranged on the outside of the pipeline integrated plate away from the reactor, and a group of second rigid pipe bodies are arranged on the pipeline external connection plate, the first rigid pipe body and the second rigid pipe body correspond to each other one by one, and the first rigid pipe body and the second rigid pipe body are connected by a hose; It also includes a vibration generating part, which includes an air hammer. The air hammer is installed on the reactor. The striking head of the air hammer extends into the outer side of the inner wall of the reactor corresponding to the filter basket. A pad is provided between the filter basket and the inner wall of the reactor corresponding to the position of the air hammer striking head.

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