Composition with water-oil coordinating effect and preparation method and application thereof

Abstract

The present invention relates to the field of cosmetic technology, and in particular to a composition with water-oil coordination effect, and a preparation method and application thereof. The composition with water-oil coordination effect comprises the following components by weight: (a) 1 part of ammonium glycyrrhizinate, 0.001-3 parts of puerarin and 0.001-3 parts of daidzein; and (b) at least two of 0.0002-0.5 parts of psoralen, 0.00005-0.1 parts of lupenone and 0.00001-0.1 parts of artemisinin. The composition of the present invention is compounded with ammonium glycyrrhizinate, puerarin and daidzein, and at the same time uses a certain amount of at least two of psoralen, lupenone and artemisinin, so that the composition has the effect of water-oil coordination, and is suitable for regulating the water-oil imbalance of people with different skin types, especially for people with oily skin, and has significant efficacy, and is safe and reliable.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a composition with water-oil blending effect, a preparation method and application thereof. Background Art

[0002] People with oily skin often have problems such as greasy skin, and the root cause of oily skin is the vigorous secretion of sebaceous glands, which leads to excessive oil on the skin surface, bringing an unrefreshing feeling. Usually, people with oily skin will remove the oil on the skin surface through deep cleansing, and often use oil-control skin care products containing ingredients such as retinoic acid and salicylic acid, as well as acid peeling, photorejuvenation, laser and other medical beauty projects to improve oil secretion. However, the use of these methods will cause certain irritation to the skin, and may cause problems with the skin barrier before the oil secretion is improved, such as skin sensitivity, redness, dryness, etc.

[0003] Therefore, if the water-oil harmonization effect can be achieved, it will be more helpful in regulating the skin condition of people with oily skin.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] One object of the present invention is to provide a composition with water-oil regulating effect, which can simultaneously regulate the oil secretion and water content, so as to keep the oil content and water content on the skin surface balanced.

[0006] Another object of the present invention is to provide a method for preparing a composition having water-oil blending effect.

[0007] Another object of the present invention is to provide a composition having water-oil blending effect for use in the preparation of skin care products.

[0008] In order to achieve the above-mentioned object of the present invention, the present invention provides a composition having the effect of water-oil coordination, comprising the following components in parts by weight:

[0009] (a) 1 part of ammonium glycyrrhizinate, 0.001 to 3 parts of puerarin and 0.001 to 3 parts of daidzein; and

[0010] (b) at least two of 0.0002 to 0.5 parts of psoralen, 0.00005 to 0.1 parts of lupenone, and 0.00001 to 0.1 parts of scoparia lactone.

[0011] In a specific embodiment of the present invention, the composition having the effect of water-oil coordination comprises the following components in parts by weight:

[0012] (a) 1 part of ammonium glycyrrhizinate, 0.001-2 parts of puerarin and 0.001-2 parts of daidzein; and,

[0013] (b) at least two of 0.0005 to 0.4 parts of psoralen, 0.0001 to 0.08 parts of lupenone, and 0.0001 to 0.08 parts of scoparone.

[0014] In a specific embodiment of the present invention, in the composition having the effect of water-oil coordination, the mass ratio of ammonium glycyrrhizinate, puerarin and daidzein is 1:(1-2):(1-2), preferably 1:(1-1.2):(1-1.2).

[0015] In a specific embodiment of the present invention, the composition having water-oil coordination effect also includes water.

[0016] The present invention also provides a method for preparing any one of the above-mentioned compositions having water-oil coordinating effects, comprising the following steps:

[0017] The components are mixed according to the proportion.

[0018] In a specific embodiment of the present invention, the preparation method comprises: mixing ammonium glycyrrhizate with water to obtain an aqueous solution of ammonium glycyrrhizate; and mixing the aqueous solution of ammonium glycyrrhizate with other components.

[0019] In a specific embodiment of the present invention, in the preparation of the aqueous solution of ammonium glycyrrhizinate, the mixing temperature is 55 to 65° C., and the mixing time is 5 to 30 minutes.

[0020] In a specific embodiment of the present invention, the amount of water used is 5 to 20 times, such as 8 to 12 times, the mass of the ammonium glycyrrhizinate.

[0021] In a specific embodiment of the present invention, the mixing treatment includes: shaking treatment at 37±2°C for 4 to 8 hours.

[0022] The present invention also provides the use of any one of the above-mentioned compositions with water-oil harmonizing effects in the preparation of skin care products.

[0023] The present invention provides a skin care product with water-oil harmonizing effect, comprising any one of the above-mentioned compositions with water-oil harmonizing effect.

[0024] In a specific embodiment of the present invention, in the skin care product, the mass fraction of the composition having water-oil coordination effect is 0.1% to 5%.

[0025] In a specific embodiment of the present invention, the skin care product further comprises additives; the additives comprise any one or more of moisturizers, thickeners, emollients, chelating agents, skin conditioners, emulsifiers, and pH regulators.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] The composition of the present invention is compounded with ammonium glycyrrhizinate, puerarin and daidzein, and a certain amount of at least two of psoralen, lupenone and scoparone is used, so that the composition has the effect of harmonizing water and oil, is suitable for regulating the water-oil imbalance of people with different skin types, especially for people with oily skin, has significant effect, and is safe and reliable. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0029] Figure 1 This is a comparison chart of the changes in oil secretion of the 1# emulsion sample prepared by the composition of Example 1 of the present invention before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0030] Figure 2 This is a comparison chart of the changes in oil secretion of the 2# emulsion sample prepared by the composition of Example 2 of the present invention before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0031] Figure 3 This is a comparison chart of the changes in oil secretion of the 3# emulsion sample prepared by the composition of Example 3 of the present invention before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0032] Figure 4 This is a comparison chart of the changes in oil secretion of the 10# emulsion sample prepared by the composition of Example 10 of the present invention before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0033] Figure 5 This is a comparison chart of the changes in oil secretion before and after volunteers used the comparative 1# lotion sample prepared by the composition of comparative example 1; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0034] Figure 6 This is a comparison chart of the change in moisture content of the 1# emulsion sample prepared by the composition of Example 1 of the present invention before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0035] Figure 7This is a comparison chart of the moisture content change of the 2# emulsion sample prepared by the composition of Example 2 of the present invention before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0036] Figure 8 This is a comparison chart of the moisture content change of the 3# emulsion sample prepared by the composition of Example 3 of the present invention before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0037] Fig. 9 This is a comparison chart of the change in moisture content of the 10# emulsion sample prepared by the composition of Example 10 of the present invention before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use;

[0038] Fig.10 This is a comparison chart of the moisture content change of the comparative 1# lotion sample prepared by the composition of comparative example 1 before and after the volunteers used it; the left side is the 0th day of sample use, and the right side is the 28th day of sample use. DETAILED DESCRIPTION

[0039] The technical scheme of the present invention will be clearly and completely described below in conjunction with the accompanying drawings and specific embodiments, but it will be understood by those skilled in the art that the following described embodiments are part of embodiments of the present invention, rather than all embodiments, and are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative work are within the scope of protection of the present invention. If specific conditions are not specified in the embodiments, they are carried out according to normal conditions or conditions recommended by the manufacturer. If the manufacturer is not specified in the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0040] In one aspect, the present invention provides a composition having the function of water-oil coordination, comprising the following components in parts by weight:

[0041] (a) 1 part of ammonium glycyrrhizinate, 0.001 to 3 parts of puerarin and 0.001 to 3 parts of daidzein; and

[0042] (b) at least two of 0.0002 to 0.5 parts of psoralen, 0.00005 to 0.1 parts of lupenone, and 0.00001 to 0.1 parts of scoparia lactone.

[0043] The structure of ammonium glycyrrhizinate is shown in Formula I:

[0044]

[0045] The core structure of ammonium glycyrrhizinate is composed of a hydrophobic molecule of glycyrrhetinic acid and two hydrophilic molecules of glucuronic acid. It is a type of triterpenoid active ingredient with a high content in licorice, and has multiple pharmacological activities such as anti-inflammatory, antibacterial, antiviral, and liver protection. Ammonium glycyrrhizinate has an amphiphilic structure and surfactant-like effect. Its general increase in the solubility of monomer components of traditional Chinese medicine is largely related to the hydrophobic inner cavity formed in aqueous solution. Ammonium glycyrrhizinate has a strong solubilizing effect on flavonoid components. Flavonoid components mostly contain phenolic hydroxyl structures. Therefore, the solubilization and stabilization effect of ammonium glycyrrhizinate on flavonoid components may also be related to weak intermolecular interactions such as hydrogen bonds. Ammonium glycyrrhizinate can self-assemble to form dimers in aqueous solution, and aggregate under certain conditions to form micelles or gels with certain spatial structures. The hydrophobic inner cavity formed by the self-assembly of ammonium glycyrrhizinate in aqueous solution can encapsulate poorly soluble drugs, thereby effectively increasing the solubility of poorly soluble drugs and avoiding drug precipitation. In addition, ammonium glycyrrhizinate can also interact with cholesterol or phospholipids on the cell membrane, thereby changing the drug's ability to be absorbed through the membrane.

[0046] The structural formula of puerarin is shown in Formula II:

[0047]

[0048] Puerarin is an isoflavone compound that is mainly found in leguminous plants and has poor water solubility. Its chemical structure is similar to that of estradiol, so it has estrogen-like effects. In addition, it can regulate the cell cycle and inhibit PTK activity; it can also inhibit insulin-stimulated glucose uptake and reduce ATP in adipocytes, and inhibit insulin-induced lipolysis in isolated rat adipocytes. Puerarin can prevent and treat cancer by inhibiting the activation of p38MAPK in the mitogen-activated protein kinase (MAPK) pathway and reducing the synthesis of inhibitory protein α in the redox-sensitive transcription factor NF-κB pathway. In addition, many metabolic diseases including diabetes and obesity can also be treated with puerarin.

[0049] The structural formula of daidzein is shown in Formula III:

[0050]

[0051] Daidzein is an isoflavone component contained in leguminous plants, which is not water-soluble and fat-soluble. It has estrogen-like effects, but its affinity with estrogen receptors is not high. Daidzein itself has a nucleus structure that is completely similar to estrogen secreted by the human body, showing estrogen-like or anti-estrogen effects, thereby inhibiting the excessive proliferation of cancer cells; for people with low estrogen levels in the body, it exerts an estrogen effect, and for people with high estrogen levels in the body, inhibiting estrogen receptors will interfere with the secretion of gonadotropin, thereby inhibiting the synthesis of estrogen, showing anti-estrogen activity. Modern research has found that daidzein also has positive therapeutic effects in many aspects such as anti-osteoporosis, inhibiting the proliferation of cancer cells in the body, and treating cardiovascular and cerebrovascular diseases, and has no obvious toxicity and side effects. At the same time, it has a variety of pharmacological effects, such as antioxidant, antibacterial, anti-inflammatory, anti-cancer, anti-estrogen activity, etc., and has no obvious toxic and side effects.

[0052] The structural formula of Psoralea corylifolia is shown in Formula IV:

[0053]

[0054] Psoralen, also known as psoralen isoflavones, is an isoflavone compound isolated from the leguminous plant Psoralea corylifolia. It has significant anti-inflammatory and anti-cancer effects.

[0055] The structural formula of lupenone is shown in Formula V:

[0056]

[0057] Lupenone belongs to the lupin-type triterpenoid compounds and can be isolated from broad-leaved Ophiopogon japonicus, Green Jade Tree, and Scutellaria baicalensis. Currently, scholars mainly use it for anti-inflammatory, antiviral, anti-cancer, and diabetes treatments.

[0058] The structural formula of artemisinin is shown in Formula VI:

[0059]

[0060] Scoparone is a natural monomer of 6,7-dimethoxycoumarin, mainly derived from Artemisia annua and Artemisia capillaris, and widely distributed in Orchidaceae, Rutaceae and Acanthopanax plants containing volatile oils. Scoparone has multiple pharmacological effects such as anti-tumor, antihypertensive, anti-lipid, anti-inflammatory, analgesic, vasodilation, and antitussive, and is often used to treat asthma, coronary heart disease, etc.

[0061] Water-oil coordination refers to regulating the skin's water content while regulating oil secretion, so that the oil content and water content on the skin surface reach a more balanced state.

[0062] The composition of the present invention is compounded with ammonium glycyrrhizinate, puerarin and daidzein, and a certain amount of at least two of psoralen, lupenone and scoparone is used, so that the composition has the effect of water-oil coordination. Puerarin and daidzein have poor solubility. The present invention further utilizes ammonium glycyrrhizinate to self-assemble in an aqueous solution to form a hydrophobic cavity, which can encapsulate the insoluble components puerarin and daidzein, and give full play to the efficacy.

[0063] In different embodiments, the composition having the effect of water-oil coordination of the present invention may include at least one of the following multiple composition modes:

[0064] (1) 1 part of ammonium glycyrrhizinate, 0.001-3 parts of puerarin, 0.001-3 parts of daidzein, 0.0002-0.5 parts of psoralen, and 0.00005-0.1 parts of lupenone;

[0065] (2) 1 part of ammonium glycyrrhizinate, 0.001-3 parts of puerarin, 0.001-3 parts of daidzein, 0.0002-0.5 parts of psoralen, and 0.00001-0.1 parts of artemisinin;

[0066] (3) 1 part of ammonium glycyrrhizinate, 0.001-3 parts of puerarin, 0.001-3 parts of daidzein, 0.00005-0.1 parts of lupenone, and 0.00001-0.1 parts of scoparia lactone;

[0067] (4) 1 part of ammonium glycyrrhizinate, 0.001-3 parts of puerarin, 0.001-3 parts of daidzein, 0.0002-0.5 parts of psoralen, 0.00005-0.1 parts of lupenone and 0.00001-0.1 parts of artemisinin.

[0068] For example, in different embodiments, in the composition having the effect of water-oil coordination of the present invention, the amounts of each component can be as follows by weight:

[0069] The dosage of puerarin can be 0.001 parts, 0.1 parts, 0.5 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts or a range consisting of any two of them;

[0070] The dosage of daidzein can be 0.001 parts, 0.1 parts, 0.5 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts or a range consisting of any two of them;

[0071] The dosage of psoralen can be 0.0002 parts, 0.002 parts, 0.02 parts, 0.05 parts, 0.08 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts or a range consisting of any two of them;

[0072] The amount of lupenone can be 0.00005 parts, 0.0005 parts, 0.005 parts, 0.008 parts, 0.01 parts, 0.02 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.08 parts, 0.1 parts or a range consisting of any two thereof;

[0073] The dosage of artemisinin can be 0.00001 part, 0.0001 part, 0.001 part, 0.002 part, 0.005 part, 0.008 part, 0.01 part, 0.02 part, 0.04 part, 0.05 part, 0.06 part, 0.08 part, 0.1 part or the range consisting of any two of them.

[0074] In a specific embodiment of the present invention, the composition having the effect of water-oil coordination comprises the following components in parts by weight:

[0075] (a) 1 part of ammonium glycyrrhizinate, 0.001-2 parts of puerarin and 0.001-2 parts of daidzein; and,

[0076] (b) at least two of 0.0005 to 0.4 parts of psoralen, 0.0001 to 0.08 parts of lupenone, and 0.0001 to 0.08 parts of scoparone.

[0077] In a specific embodiment of the present invention, in the composition having the effect of water-oil coordination, the mass ratio of ammonium glycyrrhizinate, puerarin and daidzein is 1:(1-2):(1-2), preferably 1:(1-1.2):(1-1.2).

[0078] For example, in different embodiments, in the composition, the mass ratio of ammonium glycyrrhizinate to puerarin can be 1:1, 1:1.2, 1:1.4, 1:1.5, 1:1.6, 1:1.8, 1:2 or a range consisting of any two of them; in the composition, the mass ratio of ammonium glycyrrhizinate to daidzein can be 1:1, 1:1.2, 1:1.4, 1:1.5, 1:1.6, 1:1.8, 1:2 or a range consisting of any two of them.

[0079] In a specific embodiment of the present invention, the composition having water-oil coordination effect also includes water.

[0080] The present invention also provides a method for preparing any one of the above-mentioned compositions having water-oil coordinating effects, comprising the following steps:

[0081] The components are mixed according to the proportion.

[0082] In a specific embodiment of the present invention, the preparation method comprises: mixing ammonium glycyrrhizate with water to obtain an aqueous solution of ammonium glycyrrhizate; and mixing the aqueous solution of ammonium glycyrrhizate with other components.

[0083] By preparing ammonium glycyrrhizinate into an aqueous solution of ammonium glycyrrhizinate in advance, the ammonium glycyrrhizinate is self-assembled to form a hydrophobic cavity, and then mixed with components such as puerarin and daidzein, the insoluble components such as puerarin and daidzein can be included, the solubility of the insoluble components is effectively increased and precipitation is avoided, thereby maintaining the stability of the system.

[0084] In a specific embodiment of the present invention, in the preparation of the aqueous solution of ammonium glycyrrhizinate, the mixing temperature is 55 to 65° C., and the mixing time is 5 to 30 minutes.

[0085] For example, in different embodiments, in the preparation of the aqueous solution of ammonium glycyrrhizinate, the mixing temperature can be 55°C, 56°C, 58°C, 60°C, 62°C, 64°C, 65°C or a range consisting of any two thereof; the mixing time can be 5 min, 10 min, 15 min, 20 min, 25 min, 30 min or a range consisting of any two thereof.

[0086] The above-mentioned preparation conditions ensure that ammonium glycyrrhizinate can be smoothly self-assembled in aqueous solution to form a hydrophobic cavity with a certain size.

[0087] In a specific embodiment of the present invention, the amount of water used is 5 to 20 times, such as 8 to 12 times, the mass of the ammonium glycyrrhizinate.

[0088] For example, in different embodiments, when preparing an aqueous solution of ammonium glycyrrhizinate, the amount of water used can be 5 times, 6 times, 8 times, 10 times, 12 times, 14 times, 15 times, 16 times, 18 times, 20 times the mass of the ammonium glycyrrhizinate, or a range consisting of any two of them.

[0089] In a specific embodiment of the present invention, the mixing treatment includes: shaking treatment at 37±2°C for 4 to 8 hours.

[0090] For example, in different embodiments, the oscillation treatment time may be 4 h, 5 h, 6 h, 7 h, 8 h or a range consisting of any two of them.

[0091] The present invention also provides the use of any one of the above-mentioned compositions with water-oil harmonizing effects in the preparation of skin care products.

[0092] The present invention provides a skin care product with water-oil harmonizing effect, comprising any one of the above-mentioned compositions with water-oil harmonizing effect.

[0093] In a specific embodiment of the present invention, in the skin care product, the mass fraction of the composition having water-oil coordination effect is 0.1% to 5%.

[0094] For example, in different embodiments, in the skin care product, the mass fraction of the composition with water-oil harmonizing effect can be 0.1%, 0.2%, 0.5%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5% or a range consisting of any two of them.

[0095] In a specific embodiment of the present invention, the skin care product further comprises additives; the additives comprise any one or more of moisturizers, thickeners, emollients, chelating agents, skin conditioners, emulsifiers, pH regulators, and preservatives.

[0096] In a specific embodiment of the present invention, the moisturizing agent includes any one or more of 1,3-butylene glycol, glycerin, sodium pyrrolidone hydroxy acid, hyaluronic acid, 1,2-hexanediol, propylene glycol, arachidyl alcohol, behenyl alcohol, dipropylene glycol, squalene and sorbitol.

[0097] In a specific embodiment of the present invention, the thickener includes xanthan gum, coconut diethanolamide, coconut monoethanolamide, coconut monoisopropanolamide, cocamide, lauroyl-linoleyl diethanolamide, lauroyl-myristoyl diethanolamide, isostearyl diethanolamide, linoleyl diethanolamide, myristic diethanolamide, myristic monoethanolamide, oil diethanolamide, palm monoethanolamide, castor oil monoethanolamide, sesame diethanolamide, soybean diethanolamide, stearyl diethanolamide, stearyl monoethanolamide, stearyl monoethanolamide stearate, stearamide, bovine serum, glyceryl stearate ... Monoethanolamide, wheat germ diethanolamide, PEG-3 lauramide, PEG-4 oleamide, PEG-50 tallow amide, PEG-80 glyceryl tallow esters, PEC-8PPG-3 diisostearate, PEG-200 hydrogenated glyceryl palmitate, PEG-6 beeswax, PEG-8 beeswax, PEG-12 beeswax, PEG-4 isostearate, PEG-3 distearate, PEG-4 distearate, PEG-8 distearate, PEG-150 distearate, PEG-18 glyceryl oleate / Coconut ester, PEG-8 dioleate, PEG-200 glyceryl stearate, PEG-28 glyceryl shea butter, PEG-200 glyceryl shea butter, PEG-7 hydrogenated castor oil, PEG-40 jojoba oil, PEG-2 laurate, PEG-120 methyl glucose dioleate, PEG-150 pentaerythritol tetrastearate, PEG-55 propylene glycol oleate, PEG-160 sorbitan triisostearate, PEG-8 stearate, PEG-75 stearate, PEG-100 stearate, PE Any one or more of G-150 / decyl / SMDI copolymer (polyethylene glycol-150 / decyl / methacrylate copolymer), PEG-150 / stearyl / SMDI copolymer, PEG-90, isostearate, PEG-8PPG-3 dilaurate, cetyl myristic acid, cetyl palmitate, C18-36 acid glycol ester, pentaerythritol tetrastearate, pentaerythritol tetrabehenate, propylene glycol stearate, behenyl esters, cetyl esters, tribehenyl glyceryl, trihydroxystearate glyceryl, cetyl betaine and cocoamidohydroxysulfobetaine.

[0098] In a specific embodiment of the present invention, the emollient includes any one or more of isopropyl palmitate, hydrogenated sweet almond oil, shea butter, myristyl myristate, isopropyl palmitate, octyl palmitate, ethylhexyl palmitate, isopropyl linoleate, neopentyl glycol and isononyl isononanoate.

[0099] In a specific embodiment of the present invention, the chelating agent includes any one or more of EDTA, disodium EDTA, sodium gluconate, EDTMPS and DTPMPA.

[0100] In a particular embodiment of the present invention, the skin conditioning agent comprises Quaternium-73 and / or Niacinamide.

[0101] In a specific embodiment of the present invention, the emulsifier includes any one or more of Tween-60, Tween-80, Tween-85, polyethylene glycol 4000, propylene glycol / sodium acryloyldimethyl taurate copolymer, polysorbate-60, sorbitan isostearate, TX-9 and TX-10.

[0102] In a specific embodiment of the present invention, the pH adjuster includes any one or more of HEPES, TRIS, BIS-TRIS, citric acid, tromethamine and lactic acid.

[0103] In a specific embodiment of the present invention, the preservative includes any one or more of hydroxyphenyl esters, benzyl alcohol, phenoxyethanol, potassium sorbate, methylisothiazolinone, imidazolidinyl urea, DMDM ​​hydantoin, sodium benzoate, bis(hydroxymethyl)imidazolidinyl urea, quaternary ammonium salt-15 and o-cymene-5-ol.

[0104] Examples 1 to 12

[0105] Examples 1 to 12 respectively provide compositions with water-oil coordination effects and preparation methods. The raw material compositions of the compositions with water-oil coordination effects of the specific examples are shown in Table 1.

[0106] The method for preparing the composition having the effect of water-oil coordinating comprises the following steps:

[0107] (1) Weighing ammonium glycyrrhizinate powder, adding distilled water, and heating in a water bath at 60° C. for 15 min to prepare an aqueous solution of ammonium glycyrrhizinate;

[0108] (2) Weigh the remaining components, add them to the aqueous solution of ammonium glycyrrhizinate obtained in step (1), mix well, place in a 37° C. water bath constant temperature oscillator, and oscillate for 6 hours to obtain a composition with water-oil coordinating effect.

[0109] Table 1 Raw material composition of the composition with water-oil coordinating effect in different embodiments (parts by weight)

[0110] serial number Ammonium glycyrrhizinate Puerarin Daidzein Psoralea corylifolia Lupenone Artemisinin Distilled water Example 1 1 0.001 0.001 0.0002 0.00005 — 10 Example 2 1 1 1 0.5 0.1 — 10 Example 3 1 1 1 0.3 0.05 — 10 Example 4 1 1 1 — 0.005 0.00001 10 Example 5 1 1 1 — 0.1 0.1 10 Example 6 1 1 1 — 0.05 0.05 10 Example 7 1 1 1 0.05 — 0.001 10 Example 8 1 1 1 0.5 — 0.1 10 Example 9 1 1 1 0.3 — 0.05 10 Example 10 1 1 1 0.3 0.05 0.05 10 Embodiment 11 1 1.2 1.2 0.3 0.05 0.05 10 Example 12 1 3 3 0.3 0.05 0.05 10

[0111] Example 13

[0112] This embodiment provides an emulsion with water-oil blending effect and a preparation method. The specific raw material composition of the emulsion is shown in Table 2.

[0113] The method for preparing the emulsion with water-oil coordinating effect comprises the following steps:

[0114] (1) Pre-mix according to the composition of each group in Table 2;

[0115] Pre-mix group D: Mix group D, stir until dissolved evenly, and set aside;

[0116] Pre-mixing group F: After the group F powder is evenly mixed with 1,3-butanediol, heat to 80-85°C while stirring until fully dissolved, cool to room temperature and set aside;

[0117] Pre-prepared group H: Stir the corresponding compositions with water-oil coordinating effect in Examples 1 to 12 at room temperature (they can be heated to about 50° C. as appropriate), dissolve until transparent and uniform, and set aside;

[0118] Pre-mix Group I: Mix Group I, heat to about 50°C, stir until fully dissolved, cool to room temperature, and set aside;

[0119] Pre-mix Group A: Heat water to about 70°C, disperse the powder with alcohol, pour into the stirred hot water, add other materials, heat to 80-82°C while stirring, homogenize for 1-3 minutes until completely uniform; keep warm for 20-30 minutes, disinfect and defoam, and set aside.

[0120] (2) Start homogenization and slowly add Group B and Group C into Group A. Homogenize for 3 to 5 minutes until the mixture is completely emulsified and uniform. Cool down after defoaming.

[0121] (3) Cool down to 70-75°C, add pre-mixed group D and phase E, and homogenize for 2-3 minutes until uniform.

[0122] (4) Cool down to 50-55°C, add the pre-mixed Group F, and stir thoroughly.

[0123] (5) Cool down to below 40°C, add the mixed Group G, and stir thoroughly; then add Group H, the pre-mixed Group I and Group K in sequence, and stir thoroughly until uniform.

[0124] (6) Take samples, test them, and discharge them after they pass the test.

[0125] Table 2 Raw material composition of emulsion with water-oil mixing effect

[0126]

[0127]

[0128] Among them, the emulsions prepared using the compositions with water-oil coordination effects corresponding to Examples 1 to 12 are numbered 1#, 2#, 3#, 4#, 5#, 6#, 7#, 8#, 9#, 10#, 11#, and 12#.

[0129] Comparative Examples 1 to 7

[0130] Comparative Examples 1 to 7 provide different compositions and preparation methods, respectively. The specific raw material composition of the composition of each comparative example is shown in Table 3.

[0131] The method for preparing the composition comprises the following steps:

[0132] (1) Weighing ammonium glycyrrhizinate powder, adding distilled water, and heating in a water bath at 60° C. for 15 min to prepare an aqueous solution of ammonium glycyrrhizinate;

[0133] (2) Weigh the remaining components, add them to the aqueous solution of ammonium glycyrrhizinate obtained in step (1), mix well, place in a 37° C. water bath constant temperature oscillator, and oscillate for 6 hours to obtain a corresponding composition.

[0134] Table 3 Raw material composition of the compositions of different comparative examples (parts by weight)

[0135] serial number Ammonium glycyrrhizinate Puerarin Daidzein Psoralea corylifolia Lupenone Artemisinin Distilled water Comparative Example 1 1 1 1 — — — 10 Comparative Example 2 1 1 1 0.3 — — 10 Comparative Example 3 1 1 1 — 0.05 — 10 Comparative Example 4 1 1 1 — — 0.05 10 Comparative Example 5 1 1 1 0.01 0.15 — 10 Comparative Example 6 1 1 1 0.3 0.15 0.15 10 Comparative Example 7 1 0.0008 0.0008 0.3 0.05 — 10

[0136] Comparative Example 8

[0137] Comparative Example 8 provides a different emulsion and preparation method. The raw material composition and preparation method of the specific emulsion refer to Example 13, with the only difference being that the components in Group H in Example 13 are replaced by equal weights of the compositions of Comparative Examples 1 to 7.

[0138] Among them, the emulsions prepared using the compositions corresponding to Comparative Examples 1 to 7 are numbered Comparative 1#, Comparative 2#, Comparative 3#, Comparative 4#, Comparative 5#, Comparative 6#, and Comparative 7#.

[0139] Experimental Example 1

[0140] Human efficacy testing

[0141] 1. Subject recruitment

[0142] A total of 95 subjects were recruited.

[0143] Inclusion criteria:

[0144] ① Those with oily or mixed skin (Dr. Baumann's skin classification score is between 27 and 44), who do not apply any product after washing their face the night before, do not wash their face the next morning, sit quietly for 30 minutes in a constant temperature and humidity environment, and whose forehead oil test average value reaches 100 in one test;

[0145] ②Facial lactic acid test is positive;

[0146] ③No products related to the tested efficacy have been used in the past month;

[0147] ④ Those without severe systemic diseases, immunodeficiency or autoimmune diseases;

[0148] ⑤ Those without active allergic diseases;

[0149] ⑥ Those who have no history of allergy to skin care cosmetics;

[0150] ⑦ Those who have not used hormone drugs and immunosuppressants recently;

[0151] ⑧ Those who have not participated in other human experiments or clinical trials;

[0152] ⑨ Those who are willing to participate and can complete the required content according to the test requirements;

[0153] ⑩Age: 18 to 45 years old; gender is not limited.

[0154] Exclusion criteria:

[0155] ① Those who do not meet the criteria for oily skin or those with severe acne;

[0156] ② Those who have participated in the test on oil control and its effect on skin condition within the last month;

[0157] ③People with skin allergic diseases;

[0158] ④People who are easily allergic to cosmetics;

[0159] ⑤ Those who have recently used hormone drugs and immunosuppressants;

[0160] ⑥Those with low degree of cooperation.

[0161] 2. Sample distribution

[0162] Sample name: 1#~12# samples, comparison 1#~7# samples;

[0163] Distribution: Volunteers were randomly divided into 19 groups, 5 people in each group, and samples 1# to 12# were used on the whole face, and compared with samples 1# to 7#;

[0164] Long-term effect: forehead on both sides (the area from above the eyebrow to the hairline, select 3 points at a distance of 1cm, 3cm, 5cm, and 7cm from the midline, respectively).

[0165] How to use: Use on the entire face, once in the morning and once in the evening. Use only this sample after cleansing every day, 6 to 8 drops each time or adjust the number of drops according to your own situation, apply evenly on the face and wait for it to be absorbed.

[0166] 3. Index detection

[0167] Index collection: Volunteers washed their faces and took care of their skin normally the night before, but did not wash their faces and take care of their skin on the morning of the test. After sitting in a constant temperature and humidity environment for 30 minutes, the skin oil secretion test and oil test kit (Subumeter SM810) were used to test the skin oil content at the facial test points; then the skin moisture content was collected at the facial test points using a skin moisture content tester and test probe (Corneometer CM825). Volunteers used the samples for testing on the 0th, 7th, 14th, 21st, and 28th days.

[0168] The changes in oil secretion and skin moisture content in each group are shown in Tables 4 and 5, respectively.

[0169] Table 4 Changes in oil secretion in each group (long-term)

[0170] Group Day 0 Day 7 Day 14 Day 21 Day 28 Sample 1# 174.64±35.76 172.46±28.54 167.64±36.11*# 161.21±34.33*# 158.75±27.65*# Sample 2# 177.64±16.33 170.67±26.08* 165.32±32.72*# 157.71±31.31*# 151.73±28.16*# Sample #3 175.73±27.34 168.03±33.88* 160.57±23.78*# 153.18±26.74*# 147.89±29.63*# Sample 4# 177.47±36.56 175.58±33.38* 173.97±20.24*# 171.63±19.85*# 168.64±21.9*# Sample #5 174.96±20.61 172.68±34.18* 170.74±35.58*# 167.64±38.89*# 165.16±17.78*# Sample #6 178.57±35.43 173.77±39.45* 168.36±31.81*# 165.8±28.03*# 163.07±37.35*# Sample 7# 176.86±19.77 172.1±38.17* 168.68±28.82*# 165.13±37.46*# 161.99±36*# 8# Sample 174.21±17.27 169.09±39.25* 165.71±34.22*# 161.82±27.2*# 158.75±18.93*# 9# Sample 175.41±14.85 170.72±15.93* 164.15±26.18*# 160.87±23.59*# 156.16±20.32*# Sample 10# 178.33±19.11 169.74±23.52* 156.84±37.56*# 149.21±35.64*# 141.39±22.91*# Sample 11# 178.01±19.72 170.72±15.93* 162.1±38.17*# 157.49±34.16*# 150.11±16.24*# Sample 12# 176.35±20.8 172.1±38.17* 166.28±25.6*# 160.81±24.53*# 153.61±29.11*# Compare with sample 1# 175.82±24.04 173.69±28.46* 170.49±21.87*# 167.02±29.63*# 163.97±31.33*# Compare with sample 2# 177.38±38.22 176.19±14.58 174.94±22.35 175.04±37.16 174.34±27.82 Compare with sample 3# 176.98±38.08 177.72±31.77 176.23±17.01 175.33±28.99 173.64±15.05 Compare with sample 4# 177.51±24.72 173.34±19.82 173.33±25.28 174.48±27.57* 169.76±39.3*# Compare with sample 5# 176.49±29.41 178.03±33.84 179.39±31.57 178.63±33.05 176.68±17.91 Compare with sample 6# 176.81±16.57 175.32±14.85 174.65±18.59 175.33±28.99 175.04±31.04 Compare with sample 7# 177.53±20.16 174.39±34.54 173.64±15.05 173.98±23.91 175.66±15.4

[0171] Note: *: compared with the same group, P < 0.05; #: compared with the other groups, P < 0.05.

[0172] Table 5 Changes in skin moisture content in each group (long-term)

[0173] Group Day 0 Day 7 Day 14 Day 21 Day 28 1# Sample 37.74±8.22 37.86±4.42 38.12±5.29# 39.13±6.03*# 40.12±4.38*# Sample 2# 36.17±5.37 38.35±6.25 41.46±5.82*# 42.92±8.73*# 45.23±7.24*# Sample #3 37.39±6.34 40.45±5.67 42.35±6.23# 45.13±4.76*# 48.12±5.21*# Sample 4# 37.05±4.82 38.99±7.44 39.51±4.65 41.64±3.61*# 43.62±7.06*# Sample #5 36.53±6.07 37.25±7.35 39.61±6.26 41.76±4.16*# 43.78±6.9*# Sample #6 36.87±2.85 37.04±8.36 39.01±3.49 42.3±2.83*# 44.01±6.55*# Sample 7# 36.74±3.4 37.1±9.3 38.3±2.64 38.22±2.75# 39.36±4.72# 8# Sample 37.12±6.35 37.69±2.45 38.17±3.25 39.88±8.46 40.22±7.08*# 9# Sample 37.27±4.99 38.04±3.92 39.39±6.48# 40.26±2.62*# 43.35±8.59*# Sample 10# 36.18±4.13 40.35±6.25 44.16±5.38*# 48.81±9.34*# 52.86±6.31*# Sample 11# 36.73±3.65 39.33±8.43 42.99±8.17*# 45.06±7.52*# 47.56±8.32*# Sample 12# 37.24±7.41 38.97±4.68 41.66±8.83*# 43.61±7.41*# 45.25±6.72*# Compare with sample 1# 37.43±7.65 37.39±6.33 37.21±6.35# 38.09±5.11# 38.14±6.67# Compare with sample 2# 36.82±8.11 36.03±7.48 36.17±5.71 36.55±9.44 35.97±9.41 Compare with sample 3# 35.91±6.26 36.41±2.83 36.54±7.76 37.03±5.09 37.3±2.67 Compare with sample 4# 37.24±8.05 36.3±6.93 36.59±9.22 35.95±7.69 36.5±7.87 Compare with sample 5# 36.26±7.36 36.58±5.1 37.33±5.65 35.94±8.04 36.98±7.81 Compare with sample 6# 37.09±6.25 37.04±3.67 37.18±5.97 36.98±9.09 36.27±9.2 Compare with sample 7# 36.04±6.68 37.28±2.58 36.98±3.11 36.15±6.51 36.95±2.51

[0174] Note: *: compared with the same group, P < 0.05; #: compared with the other groups, P < 0.05.

[0175] Figure 1 to Figure 5 The following is a comparison chart of the changes in oil secretion of some volunteers using the emulsion samples 1# to 3#, 10#, and Comparison 1# prepared from the compositions of Examples 1 to 3, Example 10, and Comparison 1, respectively, on the 0th day and the 28th day. Figure 1 to Figure 5 From the oil secretion of the volunteers, the oil secretion of the 5 samples decreased significantly before and after use (p < 0.05), among which the oil control ability of 10# sample > 3# sample > 2# sample > 1# sample > comparison 1# sample. In the oil distribution imaging, yellow represents oil, the more oil secretion, the redder the color, and the blue area indicates that the oil content is extremely low; we can observe that the yellow area of ​​the face of the volunteers in the 10# group has become lighter in color compared with the 0th day and the 28th day, and the chin has appeared blue, indicating that the oil secretion has decreased; the yellow area of ​​the face of the volunteers in the C and D groups has become lighter in color; the red area of ​​the volunteers in the 1# group and the comparison 1# group with higher oil secretion has improved to a certain extent, but not as obvious as the other groups.

[0176] Figure 6 to Figure 10The following is a comparison chart of the changes in skin moisture content of some volunteers using the compositions of Examples 1 to 3, Example 10, and Comparative 1, respectively, on the 0th and 28th days. According to the changes in moisture distribution in each group, the moisture content of the five samples, except for the volunteers in Comparative 1# group, increased significantly before and after use (p < 0.05), among which the water-adjusting capacity of 10# sample > 3# sample > 2# sample > 1# sample > Comparative 1# sample. In the lipid distribution imaging, blue represents moisture, the more moisture content, the darker the color, and the yellow area indicates that the moisture content is extremely low; we can observe that the blue area of ​​the face of the volunteers in Group 10# was significantly enlarged on the 0th and 28th days, and the color also showed a certain degree of deepening, indicating that the skin moisture content increased; the blue area on the face of the volunteers in Group 3# also increased significantly; the moisture content around the eyes of the volunteers in Groups 1# and 2# increased, and the dryness of other parts was alleviated to a certain extent; there was no significant difference in the facial moisture content of the volunteers in Group 1# before and after use (p > 0.05).

[0177] From the above results, it can be seen that each group of samples showed good oil control ability, and in terms of improving facial moisture content, we can observe that sample 10# has the best effect. Therefore, the present invention makes the formula have the ability of water-oil coordination by adding psoralen, scoparone, and lupenone components to the composition, and when the addition amount of psoralen, scoparone, and lupenone is in a certain proportion, the effect of water-oil coordination is significantly improved.

[0178] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A composition having water-oil coordinating effect, characterized in that: It includes the following components by weight: (a) 1 part of ammonium glycyrrhizinate, 0.001 to 3 parts of puerarin and 0.001 to 3 parts of daidzein; and, (b) at least two of 0.0002 to 0.5 parts of psoralen, 0.00005 to 0.1 parts of lupenone, and 0.00001 to 0.1 parts of scoparia lactone.

2. The composition having water-oil coordinating effect according to claim 1, characterized in that: It includes the following components by weight: (a) 1 part of ammonium glycyrrhizinate, 0.001-2 parts of puerarin and 0.001-2 parts of daidzein; and, (b) at least two of 0.0005 to 0.4 parts of psoralen, 0.0001 to 0.08 parts of lupenone, and 0.0001 to 0.08 parts of scoparone.

3. The composition having water-oil coordinating effect according to claim 1, characterized in that: The mass ratio of the ammonium glycyrrhizinate, the puerarin and the daidzein is 1:(1-2):(1-2).

4. The composition having water-oil coordinating effect according to claim 1, characterized in that: The mass ratio of the ammonium glycyrrhizinate, the puerarin and the daidzein is 1:(1-1.2):(1-1.2).

5. The composition having water-oil coordinating effect according to claim 1, characterized in that: The composition also includes water.

6. The method for preparing the composition having water-oil coordinating effect according to any one of claims 1 to 5, characterized in that: The steps include: The components are mixed according to the proportion.

7. The preparation method according to claim 6, characterized in that: include: The ammonium glycyrrhizate is mixed with water to obtain an aqueous solution of the ammonium glycyrrhizate; and the aqueous solution of the ammonium glycyrrhizate is mixed with other components for treatment.

8. The preparation method according to claim 7, characterized in that: In the preparation of the aqueous solution of ammonium glycyrrhizinate, the mixing temperature is 55 to 65° C., and the mixing time is 5 to 30 minutes.

9. The preparation method according to claim 7, characterized in that: The amount of water used is 5 to 20 times the mass of the ammonium glycyrrhizinate.

10. The preparation method according to claim 7, characterized in that: The mixing treatment includes: shaking treatment at 37±2° C. for 4 to 8 hours.

11. Use of the composition with water-oil harmonizing effect as claimed in any one of claims 1 to 5 or the composition with water-oil harmonizing effect prepared by the preparation method as claimed in any one of claims 6 to 10 in the preparation of skin care products.

12. A skin care product with water-oil blending effect, characterized in that: It comprises the composition with water-oil coordination effect as described in any one of claims 1 to 5 or the composition with water-oil coordination effect prepared by the preparation method as described in any one of claims 6 to 10.

13. The skin care product with water-oil coordination effect according to claim 12, characterized in that: The mass fraction of the composition with water-oil coordinating effect is 0.1% to 5%.

14. The skin care product with water-oil blending effect according to claim 12, characterized in that: Additives are also included.

15. The skin care product with water-oil coordination effect according to claim 14, characterized in that: The additives include any one or more of moisturizers, thickeners, emollients, chelating agents, skin conditioners, emulsifiers, and pH adjusters.

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