A method for forming microcapsules of DHA and sialic acid
By cooperating with the piston and drying gas in the drying device, the DHA and sialic acid microcapsules are quickly cooled and dried, solving the problem of DHA oxidation and deterioration, and preparing smaller and higher quality microcapsules.
Patent Information
- Application Number
- CN202410628852.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-05-21
- Publication Date
- 2025-09-30
- Estimated Expiration
- 2044-05-21
AI Technical Summary
In the prior art, during the microencapsulation process of DHA and sialic acid, DHA is easily oxidized and deteriorated at high temperatures, resulting in a decrease in the quality of the finished product.
A drying device is used to achieve adiabatic expansion and rapid cooling of the emulsion through the vertical movement of the piston and the coordination of the drying gas, forming smaller frozen particles, and utilizing the impact of the drying airflow to further reduce the powder particle diameter, thereby achieving better drying effect.
It effectively avoids the oxidation and deterioration of DHA, produces smaller microcapsules, improves the quality of the finished product, and simplifies the production process.
Smart Images
Figure CN118416800B_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of microcapsule preparation, and in particular to a method for forming microcapsules of DHA and sialic acid. Background Art
[0002] As key ingredients in infant formula, docosahexaenoic acid (DHA) and sialic acid both promote brain development and improve memory. Microalgae oil is a major source of DHA and is widely used due to its simple structure and ease of absorption. However, DHA contains multiple double bonds, making it susceptible to oxidation and degradation, losing its physiological benefits and producing harmful trans fatty acids and an unpleasant fishy odor, severely limiting its use in food. Microencapsulating DHA and milk-derived sialic acid can effectively isolate them from the external environment and prevent oxidation and degradation.
[0003] Microencapsulation is the main measure to prevent oil oxidation. Microencapsulation is the process of mixing the wall material with DHA oil and milk-derived sialic acid to form an emulsion, and using methods such as spray drying to co-encapsulate the DHA oil droplets and milk-derived sialic acid into millimeter-scale tiny particles. The smaller the microcapsule, the better the quality. For example, the prior art CN202110177041.8 discloses a high-stability algae oil DHA microcapsule and a preparation method thereof, which uses a spray drying process for hot air drying. Since DHA is an oil that easily deteriorates at high temperatures, sialic acid is relatively unstable at high temperatures, and its content is easily lost, so that traditional hot air drying does not use microcapsules containing these two ingredients. Therefore, there is a need for a microencapsulation method of DHA and sialic acid that reduces or avoids the deterioration of DHA. Summary of the Invention
[0004] The technical problem to be solved by the present invention is to provide a method for forming microcapsules of DHA and sialic acid which can reduce or avoid the deterioration of DHA.
[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is:
[0006] A method for forming microcapsules of DHA and sialic acid, comprising:
[0007] preparing an emulsion containing DHA and sialic acid;
[0008] The emulsion is dried using a drying device; the drying device includes a drying tower, a lifting motor, a pump, a collecting tank, a gas cylinder and a storage tank; the emulsion is arranged in the storage tank; the drying tower includes a piston, a spray head, a cylinder and a connecting rod, the cylinder has a working space, the spray head is arranged at the bottom of the working space, and the spray head is connected to the storage tank through the pump; the piston is arranged in the working space and divides the working space into an upper space and a lower space, and the side wall of the piston is slidably and sealedly connected to the inner side wall of the working space to form a lower space with a closed effect; a slot is provided on the top of the drying tower, the lifting motor is arranged at the top of the drying tower, one end of the connecting rod is connected to the top of the piston, and the other end is connected to the lifting motor through the slot; a discharge port and an air inlet are also provided on the side wall of the bottom of the lower space, a discharge valve is provided on the discharge port, and the collecting tank is connected to the discharge port; the gas cylinder contains compressed dry gas, and the gas cylinder is connected to the air inlet through the drying valve;
[0009] Before the drying device works, the piston position is adjusted to the bottom dead center through the lifting motor. At the same time, the pump and drying valve are closed, and the discharge valve is opened for exhaust. After exhaust, the discharge valve is closed. When the drying device works, the pump pumps the emulsion into the lower space and atomizes it through the atomizing head. At the same time, the lifting motor is started to drive the piston to move vertically upward. When the piston reaches the top dead center, the pump is closed, the drying valve is opened, and dry gas is introduced. After the air pressure in the lower space is balanced with that in the outside world, the drying valve is closed and the discharge valve is opened. The lifting motor continues to rotate to drive the piston downward to discharge the atomized and dried powder in the lower space through the discharge valve.
[0010] Preferably, the moisture content of the drying gas is less than 0.1%.
[0011] Preferably, the gas storage cylinder is also connected to the pump through an air supply valve;
[0012] When the pump is working, the air supply valve is opened.
[0013] Preferably, a truncated cone-shaped base is provided on the bottom of the lower space, and the spray head is provided on the base; a pipeline is provided in the base, and the spray head is connected to the pump through the pipeline.
[0014] Preferably, the included angle between the discharge port and the air inlet is 180°, and the level at which the air inlet is located is lower than the level at which the spray head is located.
[0015] Preferably, an auxiliary block is provided on the surface of the piston facing the lower space, and a groove matching the shape of the base is formed on the auxiliary block.
[0016] Preferably, an ultrasonic vibration motor is provided in the auxiliary block.
[0017] Preferably, the outer periphery of the drying tower is covered with a heat insulation layer.
[0018] Preferably, a scraper is provided on the side wall along the lower edge of the piston.
[0019] The beneficial effects of the present invention are as follows: by adopting the setting of the piston, when the piston moves from the bottom dead point to the top dead point, the lower space is in a sealed state in conjunction with the closed discharge valve, and at the same time the lower space becomes larger, and adiabatic expansion is performed in the lower space, so that the atomized emulsion droplets are cooled and frozen to form frozen particles, and the first cooling is performed. During the first cooling, since the emulsion droplets contain a certain amount of air, the rapid adiabatic expansion causes the air to expand rapidly, causing the droplets to further break and become smaller, and the powder particles after condensation also become smaller, thereby reducing the difficulty of spraying and the pressure requirements for the spray head and the pump, achieving better atomization effect and cooling and drying effect, making the droplets smaller, and then the formed microcapsules are also smaller, improving the quality of the microcapsules Quality, achieving multiple effects; at the same time, the drying valve is opened, the pressure of the gas storage bottle and the pressure of the lower space are very different, the rapid influx of gas forms a dry airflow, which can be cooled twice, and at the same time impact the powder, so that the powders collide with each other to a certain extent, thereby further reducing the powder particle diameter. The dry airflow can further take away moisture and at the same time impact with the airflow to increase the contact area between the dry airflow and the powder, thereby achieving better drying effect. At the same time, after the pressure is balanced, it is also convenient for subsequent discharge; the powder atomized and dried in the lower space is discharged through the discharge valve by the downward movement of the piston. Since there is only one discharge port for discharge, a negative pressure can be formed at the discharge port, and the powder is extracted through the pressure difference caused by the downward movement of the piston, and then discharged into the collection tank. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] Figure 1 This is a schematic structural diagram of a drying device used in a method for forming microcapsules of DHA and sialic acid according to a specific embodiment of the present invention;
[0021] Explanation of reference numerals: 1. Drying tower; 11. Piston; 111. Auxiliary block; 112. Scraper; 12. Spray nozzle; 13. Cylinder; 14. Connecting rod; 15. Upper space; 16. Lower space; 17. Discharge port; 18. Air inlet; 19. Base; 2. Lifting motor; 3. Pump; 4. Collecting tank; 5. Gas cylinder; 6. Storage tank; 7. Discharge valve; 8. Drying valve; 9. Air supply valve. DETAILED DESCRIPTION
[0022] To illustrate the technical content, achieved objectives and effects of the present invention in detail, the following description is given in conjunction with the embodiments and accompanying drawings.
[0023] Please refer to Figure 1 A method for forming microcapsules of DHA and sialic acid, comprising:
[0024] preparing an emulsion containing DHA and sialic acid;
[0025] The emulsion is dried using a drying device; the drying device includes a drying tower 1, a lifting motor 2, a pump 3, a collecting tank 4, a gas cylinder 5 and a storage tank 6; the emulsion is set in the storage tank 6; the drying tower 1 includes a piston 11, a spray head 12, a cylinder 13 and a connecting rod 14, the cylinder 13 has a working space, the spray head 12 is set at the bottom of the working space, and the spray head 12 is connected to the storage tank 6 through the pump 3; the piston 11 is set in the working space and divides the working space into an upper space 15 and a lower space 16, and the side wall of the piston 11 is connected to the working space. The inner side walls of the working space are slidably and sealedly connected to form a lower space 16 with a closed effect; a slot is provided on the top of the drying tower 1, and the lifting motor 2 is arranged on the top of the drying tower 1; one end of the connecting rod 14 is connected to the top of the piston 11, and the other end passes through the slot and is connected to the lifting motor 2; a discharge port 17 and an air inlet 18 are also provided on the bottom side wall of the lower space 16, and a discharge valve 7 is provided on the discharge port 17, and the collecting tank 4 is connected to the discharge port 17; the gas cylinder 5 contains compressed dry gas, and the gas cylinder 5 is connected to the air inlet 18 through the drying valve 8;
[0026] Before the drying device works, the position of the piston 11 is adjusted to the bottom dead center by the lifting motor 2, and at the same time, the pump 3 and the drying valve 8 are in the closed state, and the discharge valve 7 is in the open state for exhaust. After the exhaust is completed, the discharge valve 7 is closed; when the drying device works, the pump 3 works to pump the emulsion into the lower space 16 and atomizes it through the atomizing head, and at the same time, the lifting motor 2 is started to move the piston 11 vertically upward; when the piston 11 reaches the top dead center, the pump 3 is closed, the drying valve 8 is opened, and the dry gas is introduced. After the air pressure in the lower space 16 is balanced with that in the outside world, the drying valve 8 is closed and the discharge valve 7 is opened. The lifting motor 2 continues to rotate to drive the piston 11 downward to discharge the powder atomized and dried in the lower space 16 through the discharge valve 7.
[0027] As can be seen from the above description, by adopting the setting of the piston 11, when it moves from the bottom dead point to the top dead point, in conjunction with the closed discharge valve 7, the lower space 16 is in a sealed state, and at the same time the lower space 16 becomes larger, and adiabatic expansion is performed in the lower space 16, so that the atomized emulsion droplets are cooled and frozen to form frozen particles, and the first cooling is performed. During the first cooling, since the emulsion droplets contain a certain amount of air, the rapid adiabatic expansion causes the air to expand rapidly, causing the droplets to further break and become smaller, and the powder particles after condensation also become smaller, thereby reducing the difficulty of spraying and the pressure requirements on the spray head 12 and the pump 3. The purpose is to achieve better atomization and cooling and drying effects; at the same time, the drying valve 8 is opened, and the pressure difference between the gas cylinder 5 and the lower space 16 is large. The rapid influx of gas forms a dry airflow that can be cooled twice, and at the same time, it impacts the powder, causing a certain amount of mutual collision between the powders, thereby further reducing the powder particle diameter; the powder after atomization and drying in the lower space 16 is discharged through the discharge valve 7 by the downward movement of the piston 11. Since there is only one discharge port 17 for discharge, a negative pressure can be formed at the discharge port 17, and the powder is extracted through the pressure difference caused by the downward movement of the piston 11, and then discharged into the collection tank 4. After the DHA microcapsules are formed, they can be added to children's food to create functional healthy snacks that promote children's intellectual development. The effects of food bases that promote children's intellectual development on the processing and product characteristics of snack foods are studied. Under the premise of ensuring that the taste, color, sensory texture and nutritional components of the snacks are not affected, the development of healthy snacks that promote children's intellectual development is guided.
[0028] Furthermore, the moisture content of the drying gas is less than 0.1%.
[0029] From the above description, it can be seen that by adsorbing the moisture of the emulsion droplets / powder by dry gas, there is no need to maintain a low water content state for a long time. It only requires preparing dry gas with low water content, which makes the production process simpler.
[0030] Furthermore, the gas cylinder 5 is also connected to the pump 3 via the gas supply valve 9;
[0031] When the pump 3 is working, the air supply valve 9 is opened.
[0032] From the above description, it can be seen that by setting the air supply valve 9, preliminary drying, dehydration and cooling can be carried out, while the atomization pressure is increased to improve the atomization effect; combined with the subsequent adiabatic expansion, due to the large gas content of the droplets, the subsequent powder particle diameter is smaller, which makes cooling more convenient.
[0033] Furthermore, a truncated cone-shaped base 19 is provided on the bottom of the lower space 16 , and the spray head 12 is provided on the base 19 ; a pipeline is provided in the base 19 , and the spray head 12 is connected to the pump 3 through the pipeline.
[0034] As can be seen from the above description, the frustum-shaped base 19 allows the powder to fall freely and be discharged through the discharge port 17, thereby reducing the complexity of the structure.
[0035] Furthermore, the included angle between the discharge port 17 and the air inlet 18 is 180°, and the level at which the air inlet 18 is located is lower than the level at which the spray head 12 is located.
[0036] From the above description, it can be seen that the angle between the discharge port 17 and the air inlet 18 is 180°, so the surface compressed air can directly impact the discharge valve 7, and through the air inlet 18, the airflow can directly impact the base 19, thereby forming an upward airflow.
[0037] Furthermore, an auxiliary block 111 is provided on the surface of the piston 11 facing the lower space 16 , and a groove matching the shape of the base 19 is formed on the auxiliary block 111 .
[0038] From the above description, it can be seen that the groove can further reduce the size of the lower space 16, further increase the pressure difference, and thus improve the subsequent atomization effect.
[0039] Furthermore, an ultrasonic vibration motor is provided in the auxiliary block 111 .
[0040] It can be seen from the above description that the powder solidified on the surface of the auxiliary block 111 can be vibrated and removed by the ultrasonic vibration motor.
[0041] Furthermore, the outer periphery of the drying tower 1 is covered with a heat insulation layer.
[0042] From the above description, it can be seen that the provision of the heat insulation layer can achieve heat insulation and prevent the condensation of water droplets on the periphery of the drying tower 1 due to low temperature and the resulting powder nodules.
[0043] Furthermore, a scraper 112 is provided on the side wall of the lower edge of the piston 11 .
[0044] It can be seen from the above description that the powder on the side wall of the lower space 16 can be scraped off by the provision of the scraper 112 .
[0045] Example 1
[0046] A method for forming microcapsules of DHA and sialic acid, comprising:
[0047] An emulsion containing DHA and sialic acid is prepared, comprising:
[0048] Preparation of aqueous solution: Weigh 20 g of octenyl succinate starch, 10 g of lactic acid, 30 g of maltodextrin, 500 ml of water, and 5 g of calcium chloride, add to a beaker, mix well, and stir in a 50°C water bath for 10 min.
[0049] Mixing of water-oil phase solution: Weigh 10 g of DHA algae oil obtained by fermentation, add it to the water phase solution, and stir it in a 50°C water bath for 5 min.
[0050] Pre-emulsification: Add the water-oil mixture obtained in the previous step to the colloid mill, set the speed to 6000 rpm, and process for 2 minutes to obtain a pre-emulsified solution;
[0051] Homogenization stage: The present invention adopts a multi-step homogenization method to obtain the final emulsion; the pre-emulsion obtained in the previous step is poured into a high-pressure homogenizer, the homogenization pressure is set to 20 MPa, and after two steps of homogenization, the final emulsion is obtained.
[0052] Microcapsule production: The final emulsion is dried using a drying device; the drying device includes a drying tower 1, a lifting motor 2, a pump 3, a collecting tank 4, a gas cylinder 5 and a storage tank 6; the final emulsion is set in the storage tank 6; the drying tower 1 includes a piston 11, a spray head 12, a cylinder 13 and a connecting rod 14, the cylinder 13 has a working space, the spray head 12 is set at the bottom of the working space, and the spray head 12 is connected to the storage tank 6 through the pump 3; the piston 11 is set in the working space and divides the working space into an upper space 15 and a lower space 16, and the piston 11 is The side walls are slidably and sealedly connected to the inner side walls of the working space to form a lower space 16 with a closed effect; a slot is provided on the top of the drying tower 1, and the lifting motor 2 is arranged on the top of the drying tower 1; one end of the connecting rod 14 is connected to the top of the piston 11, and the other end passes through the slot and is connected to the lifting motor 2; a discharge port 17 and an air inlet 18 are also provided on the bottom side wall of the lower space 16; a discharge valve 7 is provided on the discharge port 17, and the collecting tank 4 is connected to the discharge port 17; the gas cylinder 5 contains compressed dry gas, and the gas cylinder 5 is connected to the air inlet 18 through the drying valve 8;
[0053] Before the drying device works, the position of the piston 11 is adjusted to the bottom dead center by the lifting motor 2, and at the same time, the pump 3 and the drying valve 8 are in the closed state, and the discharge valve 7 is in the open state for exhaust. After the exhaust is completed, the discharge valve 7 is closed; when the drying device works, the pump 3 works to pump the emulsion into the lower space 16 and atomizes it through the atomizing head, and at the same time, the lifting motor 2 is started to move the piston 11 vertically upward; when the piston 11 reaches the top dead center, the pump 3 is closed, the drying valve 8 is opened, and the dry gas is introduced. After the air pressure in the lower space 16 is balanced with that in the outside world, the drying valve 8 is closed and the discharge valve 7 is opened. The lifting motor 2 continues to rotate to drive the piston 11 downward to discharge the powder atomized and dried in the lower space 16 through the discharge valve 7.
[0054] The moisture content of the drying gas is less than 0.1% (this figure can be adjusted upon request).
[0055] The gas cylinder 5 is also connected to the pump 3 through the gas supply valve 9;
[0056] When the pump 3 is working, the air supply valve 9 is opened.
[0057] A truncated cone-shaped base 19 is provided at the bottom of the lower space 16 , and the spray head 12 is provided on the base 19 ; a pipeline is provided in the base 19 , and the spray head 12 is connected to the pump 3 through the pipeline.
[0058] The included angle between the discharge port 17 and the air inlet 18 is 180°, and the level of the air inlet 18 is lower than the level of the spray head 12 .
[0059] An auxiliary block 111 is provided on the side of the piston 11 facing the lower space 16 , and a groove matching the shape of the base 19 is formed on the auxiliary block 111 .
[0060] An ultrasonic vibration motor is provided in the auxiliary block 111 .
[0061] The outer periphery of the drying tower 1 is covered with a heat insulation layer.
[0062] A scraper 112 is provided on the side wall of the lower edge of the piston 11 .
[0063] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent transformations made using the contents of the present invention's description and drawings, or directly or indirectly applied in related technical fields, are also included in the patent protection scope of the present invention.
Claims
1. A method for forming microcapsules of DHA and sialic acid, characterized in that: include: preparing an emulsion containing DHA and sialic acid; The emulsion is dried using a drying device; the drying device includes a drying tower, a lifting motor, a pump, a collecting tank, a gas cylinder and a storage tank; the emulsion is arranged in the storage tank; the drying tower includes a piston, a spray head, a cylinder and a connecting rod, the cylinder has a working space, the spray head is arranged at the bottom of the working space, and the spray head is connected to the storage tank through the pump; the piston is arranged in the working space and divides the working space into an upper space and a lower space, and the side wall of the piston is slidably and sealedly connected to the inner side wall of the working space to form a lower space with a closed effect; a slot is provided on the top of the drying tower, the lifting motor is arranged at the top of the drying tower, one end of the connecting rod is connected to the top of the piston, and the other end is connected to the lifting motor through the slot; a discharge port and an air inlet are also provided on the side wall of the bottom of the lower space, a discharge valve is provided on the discharge port, and the collecting tank is connected to the discharge port; the gas cylinder contains compressed dry gas, and the gas cylinder is connected to the air inlet through the drying valve; Before the drying device works, the piston position is adjusted to the bottom dead center through the lifting motor. At the same time, the pump and drying valve are closed, and the discharge valve is opened for exhaust. After exhaust, the discharge valve is closed. When the drying device works, the pump pumps the emulsion into the lower space and atomizes it through the atomizing head. At the same time, the lifting motor is started to drive the piston to move vertically upward. When the piston reaches the top dead center, the pump is closed, the drying valve is opened, and dry gas is introduced. After the air pressure in the lower space is balanced with that in the outside world, the drying valve is closed and the discharge valve is opened. The lifting motor continues to rotate to drive the piston downward to discharge the atomized and dried powder in the lower space through the discharge valve.
2. The method for forming microcapsules of DHA and sialic acid according to claim 1, wherein: The moisture content of the drying gas is less than 0.1%.
3. The method for forming microcapsules of DHA and sialic acid according to claim 1, wherein: The gas storage cylinder is also connected to the pump through an air supply valve; When the pump is working, the air supply valve is opened.
4. The method for forming microcapsules of DHA and sialic acid according to claim 1, wherein: A truncated cone-shaped base is provided on the bottom of the lower space, and the spray head is provided on the base; a pipeline is provided in the base, and the spray head is connected with the pump through the pipeline.
5. The method for forming microcapsules of DHA and sialic acid according to claim 4, wherein: The included angle between the discharge port and the air inlet is 180 degrees, and the horizontal height of the air inlet is lower than the horizontal height of the spray head.
6. The method for forming microcapsules of DHA and sialic acid according to claim 4, wherein: An auxiliary block is provided on the side of the piston facing the lower space, and a groove matching the shape of the base is provided on the auxiliary block.
7. The method for forming microcapsules of DHA and sialic acid according to claim 6, wherein: An ultrasonic vibration motor is provided in the auxiliary block.
8. The method for forming microcapsules of DHA and sialic acid according to claim 1, wherein: The outer periphery of the drying tower is covered with a heat insulation layer.
9. The method for forming microcapsules of DHA and sialic acid according to claim 1, wherein: A scraper is provided on the side wall along the lower edge of the piston.