An antioxidant coenzyme Q 10 Facial mask

Abstract

The present invention belongs to the field of cosmetic preparations, and specifically relates to an antioxidant coenzyme Q 10 Facial mask and preparation method thereof. The antioxidant coenzyme Q 10 The facial mask comprises a facial mask and a base liquid; the base liquid comprises a base oil component, an antioxidant enhancer, a moisturizer, an emulsifier, a conditioner, a fragrance, a preservative and a solvent; wherein the base oil component is caprylic / capric triglyceride, tri(ethylhexanoic acid)glyceryl and jojoba seed oil, and the antioxidant enhancer is coenzyme Q 10 , yellow peel peel extract and picrorhizon root extract, the moisturizing agents are glycerin, squalane, caprylyl glycol, hyaluronic acid and betaine, and the conditioning agents are olive leaf extract and Centella asiatica extract. 10 , pomelo peel extract, and picrorhizon root extract are used in combination and show excellent antioxidant properties when added in a specific proportion, effectively improving the antioxidant properties of the overall formula of the mask base liquid.

Description

Technical Field

[0001] The present invention belongs to the field of cosmetic preparations, and specifically relates to an antioxidant coenzyme Q 10 Facial mask and preparation method thereof. Background Art

[0002] With the accelerated pace of life and the intensification of environmental pollution, the problem of skin aging has become increasingly prominent, especially skin aging caused by oxidative stress has become the focus of people's attention. Therefore, anti-oxidation has become a research hotspot in the field of skin care products. As an important form of skin care products, facial masks are favored by consumers because they act directly on the skin surface and can quickly provide the skin with the necessary nutrition and moisturizing.

[0003] There are many types of facial masks on the market, but most of them only focus on single functions such as moisturizing and whitening, and their anti-oxidation effects are not significant. 10 As a powerful antioxidant, it has the functions of scavenging free radicals and inhibiting lipid peroxidation, and has a significant effect on delaying skin aging. 10 How to effectively apply it in facial mask products and work synergistically with other ingredients to achieve better antioxidant effects is still a problem that needs to be solved.

[0004] Therefore, developing a facial mask product that has significant antioxidant effects while also being moisturizing, nourishing and safe is of great significance in order to meet consumer needs and improve skin health. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention aims to provide an antioxidant coenzyme Q 10 Mask, by utilizing Coenzyme Q 10 , Phellodendron chinense peel extract and Picrorhizon root extract to achieve excellent antioxidant efficacy.

[0006] In order to achieve the above object, the present invention discloses the following technical solutions:

[0007] The invention provides an antioxidant coenzyme Q 10 A facial mask, comprising a facial mask paper and a base liquid; the base liquid contains:

[0008] At least 0.5 wt% of an antioxidant synergist;

[0009] 35-45wt% base oil component;

[0010] 16.5-23.2wt% humectant;

[0011] 2.01-5.03 wt% conditioning agent;

[0012] The base oil components are caprylic / capric triglyceride, tri(ethylhexanoin)glyceride and jojoba seed oil;

[0013] The antioxidant synergist is coenzyme Q 10 , phellodendron chinense peel extract, and picrorhizon root extract;

[0014] The moisturizing agents are glycerin, squalane, caprylyl glycol, hyaluronic acid and betaine;

[0015] The conditioning agents are olive leaf extract and Centella asiatica extract.

[0016] Furthermore, the mass percentage of each component in the base oil composition to the base liquid is:

[0017] Caprylic / capric triglyceride 10-15%;

[0018] Triethylhexanoin 10-15%;

[0019] Jojoba seed oil 15%.

[0020] Furthermore, the mass ratio of coenzyme Q10, pomelo peel extract and picrorhizon root extract in the antioxidant enhancer is (2-3):(8-10):1.

[0021] Furthermore, the mass percentage of each component in the moisturizing agent to the base liquid is:

[0022]

[0023] Furthermore, the mass percentage of each component in the conditioning agent to the base liquid is:

[0024] Olive leaf extract 2-5%;

[0025] Centella asiatica extract 0.01-0.03%.

[0026] Furthermore, the base liquid further comprises an emulsifier, and the mass percentage of each component in the emulsifier to the base liquid is:

[0027] PEG-40 hydrogenated castor oil 0-5%;

[0028] PPG-24-glyceryl polyether-24 0-5%.

[0029] Furthermore, the base liquid also contains a preservative, and the mass percentage of each component in the preservative to the base liquid is:

[0030] Phenoxyethanol 0-1%;

[0031] Para-hydroxyacetophenone 0-1%.

[0032] The base oil components in the facial mask base liquid formula of the present invention are selected from caprylic / capric triglyceride, tri(ethylhexanoic acid) glyceride and jojoba seed oil, which improves the permeability and moisturizing properties of the facial mask; the coenzyme Q in the antioxidant synergist 10 The combined use of phellodendron chinense peel extract and picrorhizon root extract effectively improves the antioxidant effect of the mask base liquid; the moisturizer adopts a variety of moisturizing ingredients, and the compound use of glycerin, squalane, caprylyl glycol, hyaluronic acid and betaine can effectively enhance the skin's moisturizing ability; the conditioner adopts plant extracts olive leaf extract and Centella asiatica extract, which can improve skin condition and enhance skin's gloss and elasticity; the overall formula design of the mask base liquid has antioxidant, moisturizing and soothing effects.

[0033] Coenzyme Q 10 As a natural antioxidant, it can effectively remove free radicals, protect skin cells from oxidative damage, help slow down the aging process of the skin, and keep the skin young. 10 It can promote the regeneration and repair of skin cells, enhance the elasticity and firmness of the skin, promote the proliferation and differentiation of epidermal cells, enhance the skin barrier function, reduce water loss, and make the skin smoother and softer.

[0034] The extract of kumquat peel contains rich antioxidant and anti-toxic and bactericidal ingredients, such as carbazole alkaloids, kumquat amide compounds, kumquat coumarin, etc. These ingredients can effectively improve the antioxidant performance of antioxidant enhancers.

[0035] Picrorhizon root extract contains a variety of alkaloids, which have antioxidant, antibacterial, antifungal, antiviral and other biological activities. It can help regulate skin condition, provide antioxidant protection, and maintain skin health.

[0036] The present invention has found that coenzyme Q 10 The combined use of Phellodendron chinense peel extract and Picrorhizon root extract has a certain synergistic effect, which improves the antioxidant performance of a single ingredient and reduces the added concentration of a single ingredient, so that the multiple ingredients in the formula can exert excellent antioxidant performance under the specified concentration requirements.

[0037] Furthermore, the preparation method of the Wampee peel extract comprises the following steps:

[0038] Step (1), drying the kumquat peel and then crushing it to obtain kumquat peel powder.

[0039] Step (2), placing the kumquat peel powder in a 70 v / v% ethanol aqueous solution, heating to 55-65° C., soaking, filtering, and concentrating under reduced pressure to recover ethanol to obtain an extract;

[0040] Step (3), concentrating the extract obtained in step (2) by rotary distillation at 55-65° C. under reduced pressure to obtain a wampee peel extract.

[0041] The present invention also provides the aforementioned antioxidant coenzyme Q 10 The method for preparing a facial mask is characterized by comprising the following steps:

[0042] (1) According to the ratio, the aforementioned antioxidant coenzyme Q 10 The raw materials of the facial mask are mixed to obtain a mixed emulsion;

[0043] (2) Take the mask paper and immerse it in the mixed emulsion to obtain the antioxidant coenzyme Q 10 Facial mask.

[0044] Beneficial effects of the present invention:

[0045] Coenzyme Q provided by the present invention 10 , pomelo peel extract, and picrorhizon root extract are used in combination and show excellent antioxidant properties when added in a specific proportion, effectively improving the antioxidant properties of the overall formula of the mask base liquid. DETAILED DESCRIPTION

[0046] To better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. It should be understood by those skilled in the art that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0047] Unless otherwise specified, the test methods used in the specific implementation methods are all conventional methods; the materials, reagents, etc. used, unless otherwise specified, can be obtained from commercial channels; the percentages mentioned in the specific implementation methods, unless otherwise specified, are all mass percentages.

[0048] In the present invention:

[0049] Coenzyme Q 10 According to Chinese patent CN115584357B "A coenzyme Q 10 The method is prepared by the fermentation and extraction method of the invention;

[0050] Picrorhiza root extract is Picrorhiza (NEOPICRORHIZA SCROPHULARIIFLORA) root extract, INCI name is NEOPICRORHIZA SCROPHULARIIFLORA ROOT EXTRACT, purchased from Shaanxi Baichuan Biotechnology Co., Ltd.;

[0051] Clausenalansium (Lour.) Skeels is a plant of the genus Clausena in the Rutaceae family. The fruit was purchased from Guangzhou Huadu Qing Lianxiang Market, varieties are identified;

[0052] Olive leaf extract is olive (OLEA EUROPAEA) leaf extract, INCI name is OLEA EUROPAEA (OLIVE) LEAF EXTRACT, purchased from Tianzhicui Biological.

[0053] Centella asiatica extract is Centella asiatica (CENTELLA ASIATICA) root extract, INCI name is CENTELLAASIATICA ROOT EXTRACT, purchased from Tianzhicui Biological.

[0054] Other raw materials are commercially available.

[0055] Preparation of Phellodendron chinense peel extract

[0056] Step (1), selecting fresh, disease- and insect-free kumquat fruits, peeling the peel, removing the pulp and impurities, washing and drying the peel, crushing the dried kumquat peel, and passing the powder through a 100-mesh sieve to obtain kumquat peel powder;

[0057] Step (2), placing the kumquat peel powder in a 70 v / v% ethanol aqueous solution, wherein the solid-liquid ratio is 1:(4-5), heating to 55-65° C. to soak, filter, and concentrate under reduced pressure to recover ethanol to obtain an extract;

[0058] Step (3), the extract obtained in step (2) is concentrated by rotary distillation at 55-65° C. under reduced pressure until liquid is no longer evaporated and a thick paste remains, thereby obtaining a yellow peel peel extract.

[0059] Table 1 Preparation parameters of Wampee peel extract

[0060]

[0061] Preparation of Examples and Comparative Examples

[0062] Step (1), weighing the raw materials according to Tables 2 and 3, adding glycerin, caprylyl glycol, hyaluronic acid, betaine, tocopherol, ascorbic acid and tocopherol acetate into water, and stirring evenly at 50° C. to obtain phase A;

[0063] Step (2), caprylic / capric triglyceride, triethylhexanoin, squalane and jojoba seed oil are placed in an oil phase pot, stirred evenly and heated to 70° C. to obtain phase B;

[0064] Step (3), adding PEG-40 hydrogenated castor oil and PPG-24-glycerol polyether-24 to the phase B obtained in step (2), stirring evenly with a stirrer while pouring to emulsify;

[0065] Step (4), pumping the phase A obtained in step (1) into the emulsified phase B in step (3), stirring at 70° C. and a rotation speed of 800-1000 r / min for 20 min to obtain a uniformly mixed phase;

[0066] Step (5), cooling the mixed phase obtained in step (4) to 45°C, taking coenzyme Q 10 Add, stir and mix at a speed of 1500-2000r / min for 15 minutes, then add the Phellodendron chinense peel extract, Picrorhizoma Coptidis root extract, Olive leaf extract and Centella asiatica extract that have been fully dissolved and mixed with water to the mixed phase, continue to stir evenly, finally take phenoxyethanol and p-hydroxyacetophenone and add them thereto, stir evenly to obtain the mask base liquid;

[0067] Step (6), taking the cut and shaped facial mask and dipping it in the base liquid obtained in step (5), taking it out and packing it after it is fully immersed, and sterilizing it to obtain the antioxidant coenzyme Q 10 Facial mask.

[0068] Table 2 Raw materials mass percentage of each embodiment

[0069]

[0070]

[0071] Table 3 Mass percentage of raw materials in each comparative example

[0072]

[0073]

[0074] Note: “-” in the table means not added.

[0075] Performance Testing

[0076] Human skin patch test

[0077] The mask base liquids of the 4 examples and 6 comparative examples prepared above were subjected to the human skin patch test in reference to the "2022 Cosmetic Safety Technical Specifications".

[0078] The skin reaction was observed according to the standard at 30 minutes (after the indentation disappears), 24 hours and 48 hours, and the observation results were recorded (see Table 4).

[0079] Table 4 Human skin patch test results

[0080] serial number 30min 24h 48h Example 1 Level 0, 30 players Level 0, 30 players Level 0, 30 players Example 2 Level 0, 30 players Level 0, 30 players Level 0, 30 players Example 3 Level 0, 30 players Level 0, 30 players Level 0, 30 players Example 4 Level 0, 30 players Level 0, 30 players Level 0, 30 players Comparative Example 1 Level 0, 30 players Level 0, 30 players Level 0, 30 players Comparative Example 2 Level 0, 30 players Level 0, 30 players Level 0, 30 players Comparative Example 3 Level 0, 30 players Level 0, 30 players Level 0, 30 players Comparative Example 4 Level 0, 30 players Level 0, 30 players Level 0, 30 players Comparative Example 5 Level 0, 30 players Level 0, 30 players Level 0, 30 players Comparative Example 6 Level 0, 30 players Level 0, 30 players Level 0, 30 players

[0081] Determination of DPPH free radical scavenging ability:

[0082] DPPH was prepared with anhydrous ethanol to 2×10-4 mol / L solution, the mask base liquid of Example 1-4 and Comparative Example 1-6 was used as the test liquid, and several portions of 2 mL of the test liquid, anhydrous ethanol, and DPPH solution were prepared. The mixture was placed at room temperature for 30 minutes, and the absorbance was measured at a wavelength of 517 nm to obtain Ai. Each sample was measured in parallel 3 times and the average value was taken.

[0083] Vc was used as the positive control, anhydrous ethanol was used instead of DPPH to measure the absorbance value as the control Aj blank, and the absorbance Ac was measured by mixing DPPH solution and anhydrous ethanol.

[0084] The scavenging rate of DPPH free radicals of each sample to be tested was calculated according to the following formula (1) and recorded in the following Table 5.

[0085] Clearance (%) = (1-(Ai-Aj) / Ac) × 100% (1)

[0086] Wherein: Ai is the absorbance of 2mL of the test solution + 2mL of the DPPH reagent mixture; Aj is the absorbance of 2mL of the test solution + 2mL of anhydrous ethanol mixture; Ac is the absorbance of 2mL of the DPPH solution + 2mL of anhydrous ethanol mixture.

[0087] Superoxide free radical O2 - Determination of scavenging capacity

[0088] The facial mask base liquids of Examples 1-4 and Comparative Examples 1-6 were respectively used as the liquid to be tested, 1 mL of the liquid to be tested was accurately drawn, 4.5 mL of 50 mmol / L Tris-HCl buffer with pH = 8.2 was added, and then mixed, kept in a constant temperature water bath at 25°C for 20 minutes, and then taken out, 0.3 mL of 25 mmol / L pyrogallol solution was immediately added, and the mixture was reacted in a constant temperature water bath at 25°C for 5 minutes after being quickly shaken, and then 1 mL of 8 mmol / L HCl was added, and the reaction was terminated after mixing, and the absorbance was measured at 325 nm, and distilled water was used instead of the sample as a blank control. Vc was used as a positive control. Each sample was measured in parallel 3 times, and the average value was taken.

[0089] The clearance rate was calculated according to formula (2) and recorded in Table 5 below.

[0090] Clearance rate (%) = (A0-A1) / A0×100% (2)

[0091] Where: A0 is the average absorbance of the blank; A1 is the average absorbance of the liquid to be tested.

[0092] Determination of hydroxyl radical scavenging ability

[0093] The mask base liquids of Examples 1-4 and Comparative Examples 1-6 were used as the test liquids, and 1 mL 0.15 mmol / L FeSO4, 0.4 mL 2 mmol / L salicylic acid, 0.2 mL test liquid, 1 mL 6 mmol / L H2O2 and 0.4 mL distilled water were added to the test tubes of the sample group, respectively; the blank group used distilled water instead of the test liquid, and the control group used distilled water instead of salicylic acid, and reacted at 37°C for 30 minutes. Vc was used as a positive control. Each sample was measured in parallel 3 times, and the average value was taken.

[0094] The hydroxyl radical scavenging capacity was calculated according to formula (3) and recorded in Table 5 below.

[0095] Clearance rate (%) = (A 空白 -(A 样品 -A 对照 )) / A 空白 ×100%·····(3)

[0096] Table 5 Antioxidant performance test results

[0097] DPPH clearance rate (%) Superoxide anion free radical scavenging rate (%) Hydroxyl free radical scavenging rate (%) Example 1 82.4 73.1 76.6 Example 2 84.7 75.6 76.7 Example 3 87.2 77.3 79.6 Example 4 85.3 76.7 77.1 Comparative Example 1 61.3 53.4 55.7 Comparative Example 2 63.8 56.1 57.4 Comparative Example 3 46.1 40.5 43.0 Comparative Example 4 50.3 36.6 42.8 Comparative Example 5 56.4 48.3 51.1 Comparative Example 6 66.3 56.7 60.4

[0098] Result analysis:

[0099] According to the results in Table 5, the use of coenzyme Q 10 , yellow peel peel extract, and picrorhizon root extract are used in combination and exhibit excellent antioxidant properties when added in a specific ratio; as can be seen from Examples 1-4, coenzyme Q 10 The composite composition of the extract of Phellodendron chinense peel and the extract of Picrorhizon root was concentration-dependent. The higher the concentration, the better the antioxidant property. This also shows that the antioxidant property of the mask base liquid is mediated by coenzyme Q 10 , a combination of a Phellodendron chinense peel extract and a Picrorhizon root extract as key factors;

[0100] Comparison between Example 1 and Comparative Examples 1-6 shows that when coenzyme Q 10 The lack of any one ingredient in the composition of the extract of yellow peel and picrorhizon root extract or the change of the added ratio of the ingredients has a great influence on the antioxidant performance of the overall formula, indicating that coenzyme Q 10 There is a synergistic effect between the three, yellow peel peel extract and coptis root extract.

[0101] Although the specific embodiments of the present invention are described above, it should be understood by those skilled in the art that this is only for illustration and the protection scope of the present invention is defined by the appended claims. Those skilled in the art may make various changes or modifications to these embodiments without departing from the principles and essence of the present invention, but these changes and modifications all fall within the protection scope of the present invention.

Claims

1. An antioxidant coenzyme Q 10 The facial mask is characterized by: It comprises a facial mask paper and a base liquid; the base liquid contains: At least 0.5 wt% of an antioxidant synergist; 35-45wt% base oil component; 16.5-23.2wt% humectant; 2.01-5.03wt% conditioning agent; The base oil components are caprylic / capric triglyceride, tri(ethylhexanoin)glyceride and jojoba seed oil; The antioxidant synergist is coenzyme Q 10 , phellodendron chinense peel extract, and picrorhizon root extract; The moisturizing agents are glycerin, squalane, caprylyl glycol, hyaluronic acid and betaine; The conditioning agents are olive leaf extract and Centella asiatica extract; Coenzyme Q 10 , the mass ratio of the extract of Phellodendron chinense peel and the extract of Picrorhizon rhizome is (2-3):(8-10):1; The preparation method of the Wampee peel extract comprises the following steps: Step (1), drying the kumquat peel and then crushing it to obtain kumquat peel powder; Step (2), placing the kumquat peel powder in a 70 v / v% ethanol aqueous solution, heating to 55-65° C., soaking, filtering, and concentrating under reduced pressure to recover ethanol to obtain an extract; Step (3), concentrating the extract obtained in step (2) by rotary distillation at 55-65° C. under reduced pressure to obtain a kumquat peel extract.

2. The antioxidant coenzyme Q according to claim 1 10 The facial mask is characterized by: The mass percentage of each component in the base oil composition to the base liquid is: Caprylic / capric triglyceride 10-15%; Glyceryl tri(ethylhexanoate) 10-15%; Jojoba seed oil 15%.

3. The antioxidant coenzyme Q according to claim 1 10 The facial mask is characterized by: The mass percentage of each component in the moisturizing agent to the base liquid is: Glycerol 5-7%; Squalane 6-8%; Caprylyl glycol 0.2%; Hyaluronic acid 3-5%; Betaine 2-3%.

4. The antioxidant coenzyme Q according to claim 1 10 The facial mask is characterized by: The mass percentage of each component in the conditioning agent to the base liquid is: Olive leaf extract 2-5%; Centella asiatica extract 0.01-0.03%.

5. The antioxidant coenzyme Q according to claim 1 10 The facial mask is characterized by: The base liquid further comprises an emulsifier, and the mass percentage of each component in the emulsifier to the base liquid is: PEG-40 hydrogenated castor oil 2-5%; PPG-24-glyceryl polyether-24 2-5%.

6. The antioxidant coenzyme Q according to claim 1 10 The facial mask is characterized by: The base liquid further contains a preservative, and the mass percentage of each component in the preservative to the base liquid is: Phenoxyethanol 0.5-1%; Para-hydroxyacetophenone 0.5-1%.

7. The antioxidant coenzyme Q according to any one of claims 1 to 6 10 The method for preparing a facial mask is characterized in that: The following steps are involved: (1) Mixing the raw materials according to any one of claims 1 to 6 according to the proportions to obtain a mixed emulsion; (2) Take the mask paper and immerse it in the mixed emulsion to obtain the antioxidant coenzyme Q 10 Facial mask.

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