A kind of antibacterial and anti-dandruff preparation

Abstract

The present invention provides an antibacterial and anti-dandruff preparation, which includes, by weight, 5-10 parts of amphoteric surfactants, 6-12 parts of moisturizers, 0.5-3 parts of antibacterial and anti-dandruff coated microspheres, 1.5-4.5 parts of emollients, 0.1-1 parts of marine plant extracts, 0.6-2.4 parts of chelating agents, and 100 parts of deionized water. The present invention prepares an antibacterial and anti-dandruff preparation spray, in which not only a variety of marine plant extracts are added to the preparation, which can nourish hair and improve the scalp environment; but also antibacterial and anti-dandruff coated microspheres are added, which not only has less irritation and is more gentle, but also can effectively play the role of antibacterial and anti-dandruff for a long time.

Description

Technical Field

[0001] The invention relates to the field of anti-dandruff preparations, and in particular to an antibacterial and anti-dandruff preparation. Background Art

[0002] Among various scalp-related diseases, dandruff is a common and frequent scalp disease. About 50% of adults worldwide are affected by dandruff, and it is more common in men than in women. Dandruff begins in adolescence, reaches a peak in incidence and severity at around 20 years old, and becomes less prevalent in people over 50 years old. In the field of dermatology, dandruff is called "pityriasis capitis", and its clinical manifestations are excessive fine gray-white dry or slightly greasy bran-like flakes on the scalp or hair, accompanied by itching symptoms in most cases. At present, the specific pathogenesis of dandruff and its biochemical changes are not fully understood, but most studies have shown that microbiological factors and local immune responses play a major role in the pathogenesis of dandruff. A healthy scalp ecological environment is maintained by three major balances: oil, flora, and metabolic balance. When the scalp oil secretion is unbalanced, the scalp will become oily and greasy. When the scalp flora environment is unbalanced, itchy scalp will occur. If the scalp's stratum corneum metabolizes too quickly, it will fall off and form dandruff. If there are too many harmful bacteria, the scalp's stratum corneum will metabolize too quickly, and the amount of dandruff that falls off will increase.

[0003] Malassezia is a lipophilic fungus that parasitizes on the surface of human and animal skin. It can secrete a variety of lipases with broad-spectrum activity to hydrolyze triglycerides in sebum into fatty acids. Since Malassezia metabolizes saturated fatty acids and thus produces the aggregation of pro-inflammatory unsaturated fatty acids, stimulating the skin barrier and causing the stratum corneum to fall off, it has always been considered to be the pathogen of dandruff, among which restrictive Malassezia is the main pathogen. To remove dandruff, it is necessary to inhibit the excessive proliferation of Malassezia. Traditional anti-dandruff agents that inhibit Malassezia include ketoconazole, ZPT, OCT and climbazole. However, the above anti-dandruff ingredients are not only highly irritating to the scalp and eyes, but also have strong harm to the aquatic environment, and the anti-dandruff effect is not satisfactory. Summary of the invention

[0004] In view of the problems existing in the prior art, the purpose of the present invention is to provide an antibacterial and anti-dandruff preparation.

[0005] The purpose of the present invention is achieved by the following technical solutions:

[0006] An antibacterial and anti-dandruff preparation, calculated by weight, comprising:

[0007] 5-10 parts of amphoteric surfactant, 6-12 parts of moisturizer, 0.5-3 parts of antibacterial and anti-dandruff coated microspheres, 1.5-4.5 parts of emollient, 0.1-1 parts of marine plant extract, 0.6-2.4 parts of chelating agent and 100 parts of deionized water.

[0008] Preferably, the amphoteric surfactant is a mixture of one or more of dodecyl dimethyl betaine, cocamidopropyl betaine, cocamidopropyl-2-hydroxy-3-sulfopropyl betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethyl imidazoline, 2-alkyl-N-hydroxyethyl-N-hydroxypropyl sulfoimidazoline, and sodium N-lauroyl sarcosinate.

[0009] Preferably, the moisturizing agent is a mixture of one or more of propylene glycol, glycerin, hyaluronic acid, serine, maltitol, polyethylene glycol, polypropylene glycol, and sorbitol.

[0010] Preferably, the emollient is a mixture of one or more of panthenol, linoleic acid, isopropyl myristate, isopropyl palmitate, butyl myristate, and n-butyl stearate.

[0011] Preferably, the marine plant extract is a mixture of Fucus vesiculosus extract, Laminaria japonica extract and Undaria pinnatifida extract, and the mass ratio of Fucus vesiculosus extract, Laminaria japonica extract and Undaria pinnatifida extract is 0.1-1:0.1-1:0.1-1.

[0012] Preferably, the chelating agent is a mixture of one or more of citric acid, ethylenediaminetetraacetic acid, ethylene glycol diaminetetraacetic acid, and galactonic acid.

[0013] Preferably, the preparation of the antibacterial and anti-dandruff coated microspheres comprises:

[0014] S1. Prepare water phase and oil phase:

[0015] Weigh olive oil and polyglycerol-3 polyricinoleate and mix them evenly to obtain an oil phase; weigh piroctone ethanolamine salt and a cationic surfactant and mix them in deionized water, and stir them evenly to obtain a first aqueous phase; weigh bismuth chloride, sodium carboxymethyl cellulose and deionized water and mix them evenly to obtain a second aqueous phase;

[0016] S2, preparing water-in-oil-in-water emulsion:

[0017] First, the first aqueous phase is added dropwise to the continuously stirred oil phase, and after the addition is completed, it is placed in a high shear disperser for dispersion to obtain an oil-in-water emulsion; then the oil-in-water emulsion is added dropwise to the continuously stirred second aqueous phase, and after the addition is completed, it is placed in a high shear disperser for dispersion to obtain an oil-in-water emulsion;

[0018] S3. Preparation of coated microspheres:

[0019] Weigh L-cysteine ​​and water-in-oil-in-water emulsion, mix them, stir them thoroughly at room temperature, then heat them to 40-50°C, stir them at a speed of 300-600 r / min, and stir them for 1-6 hours. After stirring, cool them to room temperature, and dry them under reduced pressure to obtain antibacterial and anti-dandruff coated microspheres.

[0020] Preferably, in S1, the mass content of monounsaturated fatty acids in olive oil is 68%-75%, the acid value is ≤0.4%, and the peroxide value is ≤20.

[0021] Preferably, in the S1, the mass content of polyglycerol (diglycerol, trimer and tetraglycerol) of polyglycerol-3 polyricinoleate (PG-3PR) is ≥75%, and the HLB value is 2-4.

[0022] Preferably, in the oil phase of S1, the mass ratio of olive oil to polyglycerol-3 polyricinoleate is 55-75:3-8.

[0023] Preferably, in the first aqueous phase of S1, the mass ratio of piroctone ethanolamine (OCT) and cationic surfactant mixed in deionized water is 1.6-3.2:2.8-5.6:50.

[0024] Preferably, the cationic surfactant of S1 is a mixture of one or more of dodecyltrimethylammonium bromide, hexadecyltrimethylammonium bromide, hexadecylpyridinium chloride and cationic polyacrylamide.

[0025] Preferably, in the second aqueous phase of S1, the mass ratio of bismuth chloride, sodium carboxymethyl cellulose and deionized water is 3.4-6.8:0.6-1.2:50.

[0026] Preferably, in S2, the mass ratio of the first aqueous phase, the second aqueous phase and the oil phase is 1:1.6-2:1.2-1.4.

[0027] Preferably, in the preparation of the oil-in-water emulsion of S2, the dispersion speed of the high shear disperser is 12000-20000 r / min, and the dispersion time is 3-10 min.

[0028] Preferably, in the preparation of the water-in-oil-in-water emulsion of S2, the dispersion speed of the high shear disperser is 20000-30000 r / min, and the dispersion time is 10-20 min.

[0029] Preferably, in S3, the mass ratio of L-cysteine ​​to the water-in-oil-in-water emulsion is 4.1-8.2:100.

[0030] The preparation method of the antibacterial and anti-dandruff preparation comprises:

[0031] First, mix the amphoteric surfactant, moisturizer, emollient, chelating agent and deionized water, heat to 50-60°C, stir until dissolved evenly, then add the antibacterial and anti-dandruff coated microspheres, continue to stir evenly, cool to room temperature, and obtain the antibacterial and anti-dandruff preparation.

[0032] The beneficial effects of the present invention are:

[0033] 1. The present invention prepares an antibacterial and anti-dandruff preparation spray, which not only adds a variety of marine plant extracts to nourish hair and improve scalp environment; but also adds antibacterial and anti-dandruff coated microspheres, which are not only less irritating and more gentle, but also can effectively play an antibacterial and anti-dandruff role for a long time.

[0034] 2. The present invention adopts double emulsion as a template, forms a coating structure with a complex of L-cysteine ​​and bismuth salt, and uses piroctone olamine salt, an efficient, non-toxic and irritating antidandruff agent, as a core material to prepare a coated antibacterial antidandruff microsphere. The coated microsphere structure can adhere to the scalp or hair more easily, slowly releases piroctone olamine salt, inhibits the reproduction of Malassezia, and thus achieves a long-lasting and effective antidandruff effect.

[0035] 3. The present invention prepares the water-in-oil-in-water emulsion double emulsion (W / O / W) used for the antibacterial and anti-dandruff coated microspheres, which is prepared by using olive oil and polyglycerol-3 polyricinoleate as the oil phase, piroctone olamine salt solution as the first aqueous phase, and bismuth chloride solution as the second aqueous phase. While introducing the anti-dandruff agent piroctone olamine salt through the template of the double emulsion, bismuth ions are also introduced to prepare for the subsequent formation of the coated microsphere structure.

[0036] 4. In addition, in the process of preparing antibacterial and anti-dandruff coated microspheres of the present invention, the L-cysteine ​​used itself has certain antibacterial and antioxidant effects, and the relatively stable complex formed with bismuth not only compensates for the early antibacterial properties, but also can gradually release the anti-dandruff agent inside it, further enhancing the anti-dandruff and antibacterial effects.

[0037] 5. The antibacterial and anti-dandruff preparation prepared by the present invention does not contain allergenic ingredients, is suitable for sensitive scalps, does not cause adverse reactions such as itching and redness, and has a good alleviating and improving effect on the microecological environment of the scalp. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] The present invention is further described using the accompanying drawings, but the embodiments in the accompanying drawings do not constitute any limitation to the present invention. A person skilled in the art can obtain other drawings based on the following drawings without creative work.

[0039] Figure 1It is a schematic diagram of the infrared spectra of the antibacterial and anti-dandruff coated microspheres prepared in Example 1, Comparative Example 1 and Comparative Example 2 of the present invention.

[0040] Figure 2 This is a scanning electron microscope (SEM) image of the antibacterial and anti-dandruff coated microspheres prepared in Example 1 of the present invention. DETAILED DESCRIPTION

[0041] The technical solution of the present invention is described below through specific examples. It should be understood that the one or more method steps mentioned in the present invention do not exclude the existence of other method steps before and after the combination step or the insertion of other method steps between these explicitly mentioned steps; it should also be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention. Moreover, unless otherwise specified, the numbering of each method step is only a convenient tool for identifying each method step, and is not intended to limit the order of arrangement of each method step or to limit the scope of the present invention. The change or adjustment of the relative relationship thereof shall also be regarded as the scope of the present invention without substantially changing the technical content.

[0042] In order to better understand the above technical scheme, the exemplary embodiments of the present invention are described in more detail below. Although exemplary embodiments of the present invention are shown, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present invention and to enable the scope of the present invention to be fully communicated to those skilled in the art.

[0043] The product parameters used in the embodiment of the present invention are as follows: the mass content of monounsaturated fatty acids in olive oil is 68%-75%, the acid value is ≤0.4%, and the peroxide value is ≤20; the mass content of polyglycerol (dimer, trimer and tetraglycerol) in polyglycerol-3 polyricinoleate (PG-3PR) is ≥75%, and the HLB value is 2-4.

[0044] The present invention will be further described below in conjunction with the following examples.

[0045] Example 1

[0046] An antibacterial and anti-dandruff preparation, calculated by weight, comprising:

[0047] 6 parts of dodecyl dimethyl betaine, 2 parts of sodium N-lauroyl sarcosinate, 5 parts of glycerin, 5 parts of propylene glycol, 2 parts of antibacterial and anti-dandruff coated microspheres, 1.5 parts of panthenol, 2 parts of butyl myristate, 0.1 parts of fucus vesiculosus extract, 0.3 parts of Laminaria japonica extract, 0.2 parts of Undaria pinnatifida extract, 0.5 parts of citric acid, 1 part of ethylenediaminetetraacetic acid and 100 parts of deionized water.

[0048] Preferably, the preparation of the antibacterial and anti-dandruff coated microspheres comprises:

[0049] S1. Prepare water phase and oil phase:

[0050] Weigh olive oil and polyglycerol-3 polyricinoleate and mix them evenly, the mass ratio of olive oil to polyglycerol-3 polyricinoleate is 65:5, to obtain an oil phase; weigh piroctone olamine salt and cationic surfactant and mix them in deionized water, the mass ratio of piroctone olamine salt (OCT) and cationic surfactant mixed in deionized water is 2.4:4.2:50, and stir evenly to obtain a first aqueous phase; weigh bismuth chloride, sodium carboxymethyl cellulose and deionized water and mix them, the mass ratio of bismuth chloride, sodium carboxymethyl cellulose and deionized water is 5.1:0.9:50, and stir evenly to obtain a second aqueous phase;

[0051] S2. Preparation of water-in-oil-in-water emulsion:

[0052] First, the first aqueous phase is added dropwise into the continuously stirred oil phase. After the dropwise addition is completed, it is placed in a high shear disperser for dispersion at a speed of 16000 r / min and a dispersion time of 5 min to obtain an oil-in-water emulsion; then the oil-in-water emulsion is added dropwise into the continuously stirred second aqueous phase. After the dropwise addition is completed, it is placed in a high shear disperser for dispersion at a speed of 25000 r / min and a dispersion time of 15 min to obtain a water-in-oil-in-water emulsion; wherein the mass ratio of the first aqueous phase, the second aqueous phase and the oil phase is 1:1.8:1.3.

[0053] S3. Preparation of coated microspheres:

[0054] Weigh L-cysteine ​​and water-in-oil-in-water emulsion and mix them. The mass ratio of L-cysteine ​​to water-in-oil-in-water emulsion is 6.1:100. Stir them thoroughly at room temperature, then heat to 45°C, stir at a speed of 400 r / min, and stir for 3 h. After stirring, cool to room temperature and dry under reduced pressure to obtain antibacterial and anti-dandruff coated microspheres.

[0055] from Figure 1 It can be seen from the infrared spectrum that in Example 1 of the present invention, at 1265cm -1 The peak at 1133 cm is the vibration stretching peak of the ring structure C=O. -1 The composite stretching vibration peak of -N-OH at 1672 cm -1 The -CS stretching vibration peak is at , which can confirm that L-cysteine ​​is introduced into the coated microspheres.

[0056] The preparation method of the antibacterial and anti-dandruff preparation comprises:

[0057] First, the amphoteric surfactant, moisturizer, emollient, chelating agent and deionized water are mixed, heated to 55°C, stirred until evenly dissolved, and then the antibacterial and anti-dandruff coated microspheres are added, stirred evenly, and cooled to room temperature to obtain the antibacterial and anti-dandruff preparation.

[0058] Product parameters of this product:

[0059] Appearance: colorless to light yellow liquid;

[0060] Odor: slight characteristic odor;

[0061] Shelf life: 24 months;

[0062] Packaging specifications: 1kg / bottle, 5kg / barrel, 25kg / barrel;

[0063] Storage conditions: Keep away from freezing, avoid direct sunlight at 20-30℃, store in a sealed and dry, ventilated place; if crystals precipitate when stored at low temperature, heat to 45℃ to dissolve.

[0064] Example 2

[0065] An antibacterial and anti-dandruff preparation is different from Example 1 in that the preparation method of the antibacterial and anti-dandruff coated microspheres is different.

[0066] The preparation of the antibacterial and anti-dandruff coated microspheres comprises:

[0067] S1. Prepare water phase and oil phase:

[0068] Weigh olive oil and polyglycerol-3 polyricinoleate and mix them evenly, the mass ratio of olive oil to polyglycerol-3 polyricinoleate is 55:3, to obtain an oil phase; weigh piroctone olamine salt and cationic surfactant and mix them in deionized water, the mass ratio of piroctone olamine salt (OCT) and cationic surfactant mixed in deionized water is 1.6:2.8:50, and stir evenly to obtain a first aqueous phase; weigh bismuth chloride, sodium carboxymethyl cellulose and deionized water, the mass ratio of bismuth chloride, sodium carboxymethyl cellulose and deionized water is 3.4:0.6:50, and stir evenly to obtain a second aqueous phase;

[0069] S2. Preparation of water-in-oil-in-water emulsion:

[0070] First, the first aqueous phase is added dropwise into the continuously stirred oil phase. After the dropwise addition is completed, it is placed in a high shear disperser for dispersion at a speed of 12000 r / min and a dispersion time of 3 min to obtain an oil-in-water emulsion; then the oil-in-water emulsion is added dropwise into the continuously stirred second aqueous phase. After the dropwise addition is completed, it is placed in a high shear disperser for dispersion at a speed of 20000 r / min and a dispersion time of 10 min to obtain a water-in-oil-in-water emulsion; wherein the mass ratio of the first aqueous phase, the second aqueous phase and the oil phase is 1:1.6:1.2.

[0071] S3. Preparation of coated microspheres:

[0072] Weigh L-cysteine ​​and water-in-oil-in-water emulsion and mix them. The mass ratio of L-cysteine ​​to water-in-oil-in-water emulsion is 4.1:100. Stir them thoroughly at room temperature, then heat them to 40°C, stir them at a speed of 300 r / min, and stir them for 1 h. After stirring, cool them to room temperature and dry them under reduced pressure to obtain antibacterial and anti-dandruff coated microspheres.

[0073] Example 3

[0074] An antibacterial and anti-dandruff preparation is different from Example 1 in that the preparation method of the antibacterial and anti-dandruff coated microspheres is different.

[0075] The preparation of the antibacterial and anti-dandruff coated microspheres comprises:

[0076] S1. Prepare water phase and oil phase:

[0077] Weigh olive oil and polyglycerol-3 polyricinoleate and mix them evenly, the mass ratio of olive oil to polyglycerol-3 polyricinoleate is 75:8, to obtain an oil phase; weigh piroctone olamine salt and cationic surfactant and mix them in deionized water, the mass ratio of piroctone olamine salt (OCT) and cationic surfactant mixed in deionized water is 3.2:5.6:50, and stir evenly to obtain a first aqueous phase; weigh bismuth chloride, sodium carboxymethyl cellulose and deionized water and mix them, the mass ratio of bismuth chloride, sodium carboxymethyl cellulose and deionized water is 6.8:1.2:50, and stir evenly to obtain a second aqueous phase;

[0078] S2, preparing water-in-oil-in-water emulsion:

[0079] First, the first aqueous phase is added dropwise into the continuously stirred oil phase. After the dropwise addition is completed, it is placed in a high shear disperser for dispersion at a speed of 20,000 r / min and a dispersion time of 10 min to obtain an oil-in-water emulsion; then the oil-in-water emulsion is added dropwise into the continuously stirred second aqueous phase. After the dropwise addition is completed, it is placed in a high shear disperser for dispersion at a speed of 30,000 r / min and a dispersion time of 20 min to obtain a water-in-oil-in-water emulsion; wherein the mass ratio of the first aqueous phase, the second aqueous phase and the oil phase is 1:2:1.4.

[0080] S3. Preparation of coated microspheres:

[0081] Weigh L-cysteine ​​and water-in-oil-in-water emulsion, mix them in a mass ratio of L-cysteine ​​to water-in-oil-in-water emulsion of 4.1-8.2:100, stir them thoroughly at room temperature, then heat them to 40-50°C, stir them at a speed of 300-600 r / min, and stir them for 1-6 h. After stirring, cool them to room temperature, and dry them under reduced pressure to obtain antibacterial and anti-dandruff coated microspheres.

[0082] Example 4

[0083] An antibacterial and anti-dandruff preparation, which differs from Example 1 in that the ingredients and contents are slightly different, and are calculated by weight, and include:

[0084] 4 parts of cocamidopropyl betaine, 3 parts of 2-lauryl-N-carboxymethyl-N-hydroxyethyl imidazoline, 5 parts of propylene glycol, 3 parts of glycerin, 0.5 parts of antibacterial and anti-dandruff coated microspheres, 2 parts of panthenol, 1 part of linoleic acid, 0.3 parts of fucus extract, 0.2 parts of Laminaria japonica extract, 0.5 parts of Undaria pinnatifida extract, 1.2 parts of ethylenediaminetetraacetic acid, 0.4 parts of citric acid and 100 parts of deionized water.

[0085] The antibacterial and anti-dandruff coated microspheres were prepared in the same manner as in Example 1.

[0086] Example 5

[0087] An antibacterial and anti-dandruff preparation, which differs from Example 1 in that the ingredients and contents are slightly different, and are calculated by weight, and include:

[0088] 3 parts of cocamidopropyl-2-hydroxy-3-sulfopropyl betaine, 2 parts of sodium N-lauroyl sarcosinate, 6 parts of propylene glycol, 6 parts of glycerin, 3 parts of antibacterial and anti-dandruff coated microspheres, 2 parts of panthenol, 1.5 parts of isopropyl myristate, 0.05 parts of fucus vesiculosus extract, 0.1 parts of Laminaria japonica extract, 0.3 parts of Undaria pinnatifida extract, 1.3 parts of ethylenediaminetetraacetic acid, 0.4 parts of citric acid and 100 parts of deionized water.

[0089] The antibacterial and anti-dandruff coated microspheres were prepared in the same manner as in Example 1.

[0090] Comparative Example 1

[0091] An antibacterial and anti-dandruff preparation, which differs from Example 1 in that the antibacterial and anti-dandruff coated microspheres are replaced with an equal amount of piroctone olamine (OCT).

[0092] Comparative Example 2

[0093] An antibacterial and anti-dandruff preparation, which differs from Example 1 in that the antibacterial and anti-dandruff coated microspheres are replaced with an equal amount of L-cysteine.

[0094] Antibacterial and antidandruff test:

[0095] 1. Test Principle

[0096] The abnormal activity of Malassezia is also considered to be one of the main causes of dandruff formation. Therefore, many anti-dandruff products improve dandruff by adding functional substances to control the growth of Malassezia on the head. For products with this kind of anti-dandruff principle, the inhibition of the sample on Malassezia can be used as an evaluation indicator of the sample's anti-dandruff performance. According to the standard of the suspension quantitative method of "Evaluation Method for Antibacterial and Antibacterial Effect of Daily Chemical Products" QB / T 2738-20237.3, the anti-dandruff effect of anti-dandruff products is evaluated: the test uses Malassezia furfur as the indicator bacteria. After the specified time of action, the number of colonies on the test sample is recovered, and its antibacterial value is calculated. By comparing the inhibition results of the control sample and the test sample on Malassezia, the anti-dandruff effect of the sample is evaluated.

[0097] 2. Instruments, Equipment and Reagents

[0098] 2.1 Instruments and equipment:

[0099] Electronic balance; biological safety cabinet; biochemical incubator.

[0100] 2.2 Reagents and consumables:

[0101] Leeming and Notman medium; 0.03 mol / L phosphate buffered saline (PBS)

[0102] 2.3 Test substances

[0103] Sample group: products of Example 1, Comparative Example 1 and Comparative Example 2.

[0104] Control group: PBS + Malassezia furfur ATCC44344.

[0105] 3. Test method:

[0106] First, some hair from patients who are prone to dandruff was collected and evenly divided into multiple parts. Then, the hair of the patients was soaked in the products of the sample group and the control group for 10 minutes, and then the hair was filtered out and dried naturally.

[0107] Then take the Malassezia furfur suspension, divide it into several portions and place them in flat dishes, pour in the Malassezia furfur culture medium and mix evenly, and add the above-treated hair respectively. After it solidifies, turn the plate over, put it in an incubator for culture, and count the live bacteria.

[0108] 4. Calculation formula

[0109] Malassezia furfur inhibition rate (%) = (AB) / A*100%;

[0110] Where: A is the average colony count of the control group; B is the average colony count of the sample group.

[0111] 5. Results Analysis

[0112] Evaluation criteria: If the inhibition rate is >50%-90%, the product has an antibacterial effect; if the inhibition rate is >90%, the product has a strong antibacterial effect.

[0113] 6. Experimental results:

[0114] Example 1 Comparative Example 1 Comparative Example 2 1h antibacterial rate 98.3％ 98.5％ 87.6％ 24h antibacterial rate 99.8％ 96.2％ 82.1％

[0115] It can be seen from the above table that the preparation of Example 1 of the present invention has a good antibacterial rate for Malassezia furfur at 1 hour, which may be attributed to the fact that the effect of the antibacterial and anti-dandruff coated microspheres in the preparation is not weak in itself, and a large amount of microspheres remain on the hair, so the antibacterial rate can reach the level of conventional piroctone olamine salt; and the antibacterial rate after 24 hours is better, and the possible reason is that, with the passage of time, some of the effective antibacterial components in Comparative Examples 1 and Comparative Examples 2 are gradually lost, while the inhibitory effect of more antidandruff agents continuously released in Example 1 on Malassezia furfur is gradually enhanced.

[0116] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms should not be understood as necessarily being directed to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine different embodiments or examples described in this specification.

[0117] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. An antibacterial and anti-dandruff preparation, characterized in that: Calculated by weight, including: 5-10 parts of amphoteric surfactant, 6-12 parts of moisturizer, 0.5-3 parts of antibacterial and anti-dandruff coated microspheres, 1.5-4.5 parts of emollient, 0.1-1 parts of marine plant extract, 0.6-2.4 parts of chelating agent and 100 parts of deionized water; The preparation of the antibacterial and anti-dandruff coated microspheres comprises: S1. Prepare water phase and oil phase: Weigh olive oil and polyglycerol-3 polyricinoleate and mix them evenly to obtain an oil phase; weigh piroctone ethanolamine salt and a cationic surfactant and mix them in deionized water, and stir them evenly to obtain a first aqueous phase; weigh bismuth chloride, sodium carboxymethyl cellulose and deionized water and mix them evenly to obtain a second aqueous phase; S2. Preparation of water-in-oil-in-water emulsion: First, the first aqueous phase is added dropwise to the continuously stirred oil phase, and after the addition is completed, it is placed in a high shear disperser for dispersion to obtain an oil-in-water emulsion; then the oil-in-water emulsion is added dropwise to the continuously stirred second aqueous phase, and after the addition is completed, it is placed in a high shear disperser for dispersion to obtain an oil-in-water emulsion; S3. Preparation of coated microspheres: Weigh L-cysteine ​​and water-in-oil-in-water emulsion, mix them, stir them thoroughly at room temperature, then heat them to 40-50°C, stir them at a speed of 300-600 r / min, and stir them for 1-6 hours. After stirring, cool them to room temperature, and dry them under reduced pressure to obtain antibacterial and anti-dandruff coated microspheres.

2. The antibacterial and anti-dandruff preparation according to claim 1, characterized in that: The amphoteric surfactant is a mixture of one or more of dodecyl dimethyl betaine, cocamidopropyl betaine, cocamidopropyl-2-hydroxy-3-sulfopropyl betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethyl imidazoline, 2-alkyl-N-hydroxyethyl-N-hydroxypropyl sulfoimidazoline, and sodium N-lauroyl sarcosinate.

3. The antibacterial and anti-dandruff preparation according to claim 1, characterized in that: The moisturizing agent is a mixture of one or more of propylene glycol, glycerin, hyaluronic acid, serine, maltitol, polyethylene glycol, polypropylene glycol, and sorbitol.

4. The antibacterial and anti-dandruff preparation according to claim 1, characterized in that: The emollient is a mixture of one or more of panthenol, linoleic acid, isopropyl myristate, isopropyl palmitate, butyl myristate, and n-butyl stearate.

5. The antibacterial and anti-dandruff preparation according to claim 1, characterized in that: The marine plant extract is a mixture of a Fucus vesiculosus extract, a Laminaria clarkii extract and a Undaria pinnatifida extract, and the mass ratio of the Fucus vesiculosus extract, the Laminaria clarkii extract and the Undaria pinnatifida extract is 0.1-1:0.1-1:0.1-1.

6. The antibacterial and anti-dandruff preparation according to claim 1, characterized in that: The chelating agent is a mixture of one or more of citric acid, ethylenediaminetetraacetic acid, ethylene glycol diaminetetraacetic acid, and galactose acid.

7. The antibacterial and anti-dandruff preparation according to claim 1, characterized in that: In the oil phase of S1, the mass ratio of olive oil to polyglycerol-3 polyricinoleate is 55-75:3-8; in the first aqueous phase of S1, the mass ratio of piroctone ethanolamine salt and cationic surfactant mixed in deionized water is 1.6-3.2:2.8-5.6:50; in the second aqueous phase of S1, the mass ratio of bismuth chloride, sodium carboxymethyl cellulose and deionized water is 3.4-6.8:0.6-1.2:

50.

8. The antibacterial and anti-dandruff preparation according to claim 1, characterized in that: In S2, the mass ratio of the first aqueous phase, the second aqueous phase and the oil phase is 1:1.6-2:1.2-1.

4.

9. The antibacterial and anti-dandruff preparation according to claim 1, characterized in that: In the S3, the mass ratio of L-cysteine ​​to the water-in-oil-in-water emulsion is 4.1-8.2:100.

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