A head fixation device for non-human primates

Abstract

The present invention relates to a head fixing device for non-human primates, which comprises: a fixing frame; a head fixing part, which is arranged on the upper part of the fixing frame, and is movably connected to the fixing frame, and comprises a first head fixing part and a second head fixing part, and the first head fixing part and the second head fixing part are arranged in a mirror image, and both the first head fixing part and the second head fixing part have a clamping part, and the clamping part is adapted to the head of a monkey, and the clamping parts on the first head fixing part and the second head fixing part can approach or move away from each other, and can clamp or loosen the head of the monkey; the head extends out from the top of the fixing frame, and the head fixing part clamps and fixes the head, so as to fix the head of the non-primate.

Description

Technical Field

[0001] The invention belongs to the technical field of medical devices, and in particular relates to a head fixing device for non-human primates. Background Art

[0002] Non-human primates have many biological and behavioral characteristics similar to humans, and therefore play an important role in research activities such as human biology, disease, drug development, and experimental animal science. As humans continue to deepen their understanding of drug development and preclinical experiments, the demand for non-human primate experimental animals is also increasing.

[0003] At present, the devices for fixing non-human primates mostly restrict the hands, feet and heads of non-human primates to ensure the safety of the staff, and are mostly used for physical examinations in the fields of animal rescue, animal research, eye or brain medical experiments, etc.; monkeys are currently used for experiments. The current head fixing device for monkeys does not have an adjustment function and is not suitable for monkeys with different body shapes. In addition, the structure for fixing the monkey's head does not match the head structure of the monkey. The head fixation is unstable and the matching degree is poor. After fixation, it is still easy to move, which affects the behavior of the monkey. The operation is complicated, and the current device for fixing monkeys allows the monkey to stretch out its arms to adjust the structure of the head or other positions, which affects the effect of fixation. However, there is currently a lack of dedicated seats for animals to complete behavior in an awake state, and collect multimodal physiological signals at the same time, which is used to study the neural circuit structure and working principle of the advanced cognitive function of primates, the pathogenic mechanism of brain diseases, etc. Therefore, a device with a head fixation function is urgently needed to solve the above problems.

[0004] In view of the above problems, the present invention provides a head fixing device for non-human primates. Summary of the invention

[0005] In order to overcome the problems raised in the background technology, the present invention adopts the following technical solutions:

[0006] A head fixing device for a non-human primate, comprising:

[0007] Fixed frame;

[0008] A head fixing part is arranged on the upper part of the fixing frame, the head fixing part is movably connected to the fixing frame, the head fixing part comprises a first head fixing part and a second head fixing part, the first head fixing part and the second head fixing part are arranged in a mirror image, the first head fixing part and the second head fixing part both have a clamping part, the clamping part is adapted to the monkey's head, the clamping parts on the first head fixing part and the second head fixing part can approach or move away from each other, and can clamp or loosen the monkey's head; the head extends out from the top of the fixing frame, and the head fixing part clamps and fixes the head, thereby fixing the head of the non-human primate.

[0009] Furthermore, the fixed frame has a top plate, the interior of the fixed frame is hollow, and a first opening is arranged on the top plate of the fixed frame, and the first opening is a rectangular opening.

[0010] Furthermore, the top plate gradually tilts downward from the rear end to the front end; the monkey's neck is tilted forward, and the above arrangement can better fit the monkey's neck and will not affect the monkey's field of vision.

[0011] Furthermore, support plates are mirror-imaged on both sides of the first opening, the support plates are fixedly connected to the fixed frame, the lower surface of the support plates is coplanar with the lower surface of the top plate, and the upper surface of the support plates is lower than the upper surface of the top plate.

[0012] Furthermore, the first head fixing part also includes a sheet metal part and an adjusting part, the sheet metal part is arranged on any side of the top plate, the sheet metal part is movably connected to the top plate, the sheet metal part can move relative to the top plate in the front and rear directions, the adjusting part is partially arranged in the sheet metal part, and the adjusting part can move up and down in the sheet metal part; the above-mentioned arrangement ensures that the adjusting part can move forward and backward and up and down, and can adjust the position of the first head fixing part according to the body shape of the monkey, thereby ensuring that the device can be suitable for monkeys of different body shapes, improving the comfort of the monkeys, and increasing the accuracy of the experiment.

[0013] Furthermore, the sheet metal part includes a support leg and a bow portion; two support legs are provided, respectively provided on both sides of the bow portion, the support legs can be fixed on the top plate, and a rectangular space is formed in the bow portion to accommodate the adjustment member.

[0014] Furthermore, at least one first slot hole is arranged on the support leg, and a threaded hole is arranged at a corresponding position of the top plate, and a bolt is arranged in the first slot hole and the threaded hole. The bolt is tightened in the threaded hole, and the bolt presses the support leg and the top plate to fix the sheet metal part to the top plate; when the bolt is loosened, the first slot hole on the sheet metal part support leg can be moved along the bolt to adjust the front and rear position, thereby ensuring that the position of the monkey's head is fixed appropriately and ensuring the comfort of the monkey.

[0015] Furthermore, the bow portion includes two longitudinal plates and one transverse plate, wherein the transverse plate is arranged on the top of the longitudinal plates, and the transverse plate fixedly connects the two longitudinal plates; and at least one second slot hole is arranged on the longitudinal plate.

[0016] Furthermore, the adjusting member includes a fixed block, a first movable block, a second movable block and a lead screw; two optical rods are arranged between the first movable block and the second movable block, the optical rod is fixedly connected to the first movable block and the second movable block, the first end of the lead screw is arranged in the first movable block, the first end of the lead screw is rotatably connected to the first movable block, the second end of the lead screw passes through the second movable block, the lead screw is rotatably connected to the second movable block, a threaded hole and two through holes are arranged in the fixed block, the lead screw is adapted to the threaded hole in the fixed block, the lead screw passes through the threaded hole in the fixed block, and the optical rod passes through the through hole in the fixed block; when the fixed block is fixed, the lead screw is rotated, and the first movable block and the second movable block move along the axial direction of the lead screw.

[0017] Furthermore, the fixing block is arranged in a rectangular space in the bow portion of the sheet metal part, a threaded hole is arranged on the fixing block, the threaded hole is aligned with the second slot hole, a bolt is arranged in the threaded hole and the second slot, and when in a loosened state, the fixing block can move up and down in the bow portion of the sheet metal part; after tightening, the fixing block is fixed to the sheet metal part, and the above arrangement realizes multi-directional adjustment of the first head fixing part, ensuring that the position of the monkey's head is fixed appropriately and ensuring the comfort of the monkey.

[0018] Furthermore, an operating portion is provided at the second end of the lead screw, and the rotating operating portion can drive the lead screw to rotate; the above arrangement ensures convenient operation.

[0019] Furthermore, the clamping member is fixedly connected to the first moving block, and when the first head fixing member and the second head fixing member are close to each other, a space for fixing the monkey's head can be formed between the clamping members on both sides.

[0020] Furthermore, a space for placing the monkey's head is provided inside the clamping piece, and a circular space can be formed inside when the two clamping pieces are closed. An observation port is provided at the front end of the clamping piece, exposing the monkey's glasses, nose and mouth.

[0021] Furthermore, the first head fixing member and the second head fixing member are mirror-imaged and have the same structure, and when the operating parts of the first head fixing member and the second head fixing member are rotated, the clamping members on both sides move closer to or farther from each other.

[0022] Furthermore, a face shield is provided at the front end of the top plate, the face shield is fixedly connected to the top plate, and a second opening is provided in the middle of the face shield, which can ensure that the monkey has a wide and clear field of vision and prevent the monkey's arms from grabbing other equipment during the experiment.

[0023] Furthermore, both ends of the face shield extend toward the rear end of the top plate.

[0024] Furthermore, a projection opening is provided on the front side of the fixed frame, and the monkey's arm can be extended through the projection opening to test the monkey's attention and cognitive ability in a waking state.

[0025] Furthermore, a third opening is provided on the rear side of the fixed frame, guide grooves are provided on both sides of the third opening, a baffle is provided in the guide groove, and the baffle is slidably connected to the guide groove; the monkey can be put into the fixed frame through the third opening, and after being fixed, the baffle is inserted into the guide groove on the side of the third opening to prevent the monkey from escaping, affecting the progress of the experiment or even scratching the experimenter.

[0026] Beneficial effects of the invention: The invention has a reasonable structure;

[0027] The monkey's head can be fixed at a suitable left and right position through the separate adjustment settings of the first fixing member and the second fixing member, mainly fixed in the middle, but the left and right position can be adjusted according to the monkey's situation after being set in the middle. By setting the sheet metal parts that accommodate the adjustment parts and setting slots thereon, the fixing frame can be fixed to different front and back positions and up and down positions by bolts, which can achieve the front and back and up and down height adjustment of the monkey's head, and finally achieve the adjustment of the head position in three dimensions of front and back, left and right, and up and down, so as to ensure that the monkey's head maintains the best comfortable observation position after being fixed, and reduce the adverse interference to the monkey's observation and learning behavior caused by incorrect posture.

[0028] The setting of the clamping piece can ensure that the monkey's head is fixed in the clamping piece, and the monkey's head and the clamping piece will not rotate at a large angle, so that the monkey's face faces the observation port, ensuring effective observation and learning time.

[0029] The setting of the protective cover can prevent the monkey from touching the fixing parts and other structures. The setting of the extension opening on the protective cover can ensure the observation of the monkey and enable the monkey to feed itself when it obtains food rewards. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a schematic diagram of the structure of the first head fixing member and the second head fixing member of the present invention;

[0031] Figure 2 It is a schematic diagram of the structure of the head fixing part of the present invention;

[0032] Figure 3 It is a structural schematic diagram of the sheet metal part of the present invention;

[0033] Figure 4 It is a schematic diagram of the structure of the clamping member of the present invention;

[0034] Figure 5 It is a structural schematic diagram of the fixing block of the present invention;

[0035] Figure 6 It is a schematic diagram of the structure of the present invention from the first viewing angle as a whole;

[0036] Figure 7 It is a schematic diagram of the structure of the second viewing angle of the whole invention;

[0037] Figure 8 It is a schematic diagram of the structure of the present invention as a whole from a third viewing angle;

[0038] Fig. 9 It is a structural schematic diagram of the waist limiting member of the present invention;

[0039] Fig.10 It is a structural schematic diagram of the seat component of the present invention;

[0040] In the figure, 1, fixed frame; 2, waist limiter; 3, seat component; 4, top plate; 5, support plate; 6, fixed part; 7, moving part; 13, sheet metal part; 14, first slot; 15, fixed block; 16, first moving block; 17, second moving block; 18, lead screw; 19, light rod; 20, second slot; 21, operating part; 22, clamping part; 23, face shield; 24, extension port; 25, guide groove; 29, moving Plate; 30, longitudinal plate; 31, seat plate; 32, back plate; 33, first fixed plate; 34, second fixed plate; 36, supporting structure; 37, feces storage part; 38, locking piece; 39, support leg; 40, bow part; 41, first straight slot hole; 42, second straight slot hole; 43, third straight slot hole; 44, first opening; 45, second opening; 46, third opening; 47, fourth opening; 48, fifth opening; 49, long strip hole. DETAILED DESCRIPTION

[0041] The technical solutions in the embodiments of the present invention are described clearly and completely below through specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation methods. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] Example 1

[0043] Please refer to Figure 1-7 , a head fixing device for a non-human primate in this embodiment comprises:

[0044] A fixing frame 1; a head fixing part, which is arranged on the upper part of the fixing frame 1, and is movably connected to the fixing frame 1, and the head fixing part comprises a first head fixing part and a second head fixing part, and the first head fixing part and the second head fixing part are arranged in a mirror image, and both the first head fixing part and the second head fixing part have a clamping part 22, and the clamping part 22 is adapted to the monkey's head, and the clamping parts 22 on the first head fixing part and the second head fixing part can approach or move away from each other, and can clamp or loosen the monkey's head; the head extends out from the top of the fixing frame 1, and the head fixing part clamps and fixes the head, thereby fixing the head of the non-human primate.

[0045] The fixed frame 1 is made of a transparent material; the fixed frame 1 has a top plate 4, the interior of the fixed frame 1 is hollow, and a first opening 44 is provided on the top plate 4 of the fixed frame 1, and the first opening 44 is a rectangular opening.

[0046] Support plates 5 are mirror-imaged on both sides of the first opening 44, and the support plates 5 are fixedly connected to the fixed frame 1. The lower surface of the support plates 5 is coplanar with the lower surface of the top plate 4, and the upper surface of the support plates 5 is lower than the upper surface of the top plate 4. Two support plates 5 are provided, which are fixedly connected to the inner sides of the first opening 44 respectively, and there is a space between the two support plates 5, and the monkey's neck can be placed in this space.

[0047] Please refer to Figure 1-2 In this embodiment, the first head fixing member also includes a sheet metal member 13 and an adjusting member. The sheet metal member 13 is arranged on any side of the top plate 4. The sheet metal member 13 is movably connected to the top plate 4. The sheet metal member 13 can move relative to the top plate 4 in the front and rear directions. The adjusting member is partially arranged in the sheet metal member 13, and the adjusting member can move up and down in the sheet metal member 13. The above arrangement ensures that the adjusting member can move forward and backward and up and down, and can adjust the position of the first head fixing member according to the body shape of the monkey, thereby ensuring that the device can be suitable for monkeys of different body shapes, improving the comfort of the monkeys, and increasing the accuracy of the experiment.

[0048] The sheet metal part 13 includes a support leg 39 and a bow part 40; two support legs 39 are provided, respectively provided on both sides of the bow part 40, and the support legs 39 can be fixed on the top plate 4. A rectangular space is formed in the bow part 40 to accommodate the adjustment member.

[0049] At least one first slot hole 14 is set on the support leg 39, and a threaded hole is set at the corresponding position of the top plate 4. A bolt is set in the first slot hole 14 and the threaded hole. The bolt is tightened in the threaded hole, and the bolt presses the support leg 39 and the top plate 4 to fix the sheet metal 13 and the top plate 4; when the bolt is loosened, the first slot hole 14 on the support leg 39 of the sheet metal 13 can be moved along the bolt to adjust the front and rear position, thereby ensuring that the position of the monkey's head is fixed appropriately and ensuring the comfort of the monkey.

[0050] The bow portion 40 includes two longitudinal plates 30 and a transverse plate. The transverse plate is disposed on the top of the longitudinal plates 30 , and the transverse plate fixedly connects the two longitudinal plates 30 . At least one second slot hole 20 is disposed on the longitudinal plate 30 .

[0051] Please refer to Figure 1 In this embodiment, the adjusting member includes a fixed block 15, a first moving block 16, a second moving block 17 and a lead screw 18; two light rods 19 are arranged between the first moving block 16 and the second moving block 17, the light rod 19 is fixedly connected to the first moving block 16 and the second moving block 17, the first end of the lead screw 18 is arranged in the first moving block 16, the first end of the lead screw 18 is rotatably connected to the first moving block 16, the second end of the lead screw 18 passes through the second moving block 17, the lead screw 18 is rotatably connected to the second moving block 17, a threaded hole and two through holes are arranged in the fixed block 15, the lead screw 18 is adapted to the threaded hole in the fixed block 15, the lead screw 18 passes through the threaded hole in the fixed block 15, and the light rod 19 passes through the through hole in the fixed block 15; when the fixed block 15 is fixed, the lead screw 18 is rotated, and the first moving block 16 and the second moving block 17 move along the direction of the lead screw 18.

[0052] The fixing block 15 is arranged in the rectangular space in the bow portion 40 of the sheet metal part 13. A threaded hole is arranged on the fixing block 15. The threaded hole is aligned with the second slot hole 20. A bolt is arranged in the threaded hole and the second slot. When loosened, the fixing block 15 can move up and down in the bow portion 40 of the sheet metal part 13; after tightening, the fixing block 15 is fixed to the sheet metal part 13. The above arrangement realizes multi-directional adjustment of the first head fixing part, ensures that the position of the monkey's head is fixed appropriately, and ensures the comfort of the monkey.

[0053] An operating portion 21 is disposed at the second end of the lead screw 18 , and rotating the operating portion 21 can drive the lead screw to rotate; the above arrangement ensures convenient operation.

[0054] Please refer to Figure 3 In this embodiment, the clamping member 22 is fixedly connected to the first moving block 16. When the first head fixing member and the second head fixing member are close to each other, a space for fixing the monkey's head can be formed between the clamping members 22 on both sides; a space for placing the monkey's head is provided inside the clamping member 22, and a circular space can be formed inside when the two clamping members 22 are closed. An observation port is provided at the front end of the clamping member 22 to expose the monkey's glasses, nose and mouth.

[0055] The first head fixing member and the second head fixing member are mirror-imaged and have the same structure. When the operating parts 21 of the first head fixing member and the second head fixing member are rotated, the clamping members 22 on both sides are moved closer to or away from each other.

[0056] Please refer to Figure 5-7In this embodiment, a face shield 23 is provided at the front end of the top plate 4, the face shield 23 is fixedly connected to the top plate 4, and a second opening 45 is provided in the middle of the face shield 23, which can ensure that the monkey has a wide and clear field of vision and prevent the monkey's arms from grabbing other equipment during the experiment; two eye openings and one mouth opening adapted to the monkey's facial structure are provided on the face shield 23, which is convenient for the monkey to observe and eat.

[0057] Both ends of the face shield 23 extend toward the rear end direction of the top plate 4 .

[0058] A protruding opening 24 is provided on the front side of the fixed frame 1, and the monkey's arm can be extended through the protruding opening 24 to test the monkey's attention and cognitive ability in a waking state.

[0059] Please refer to Figure 6 In this embodiment, the non-human primate head fixing device also includes a neck fixing device, which is arranged on the support plate 5 and can fix the collar on the monkey's neck; when the monkey is placed in the device, the collar is on its neck, which is convenient for controlling the monkey and is more comfortable when fixing the monkey's neck, and has a certain buffering effect.

[0060] The neck fixing device includes a fixing member 6 and a moving member 7; the fixing member 6 is fixedly connected to the front end of the support plate 5, and the moving member 7 is arranged at the rear end of the support plate 5, and the moving member 7 can slide along the support plate 5, and the moving member 7 can approach or move away from the fixing member 6. The fixing member 6 is a rectangular plate, and the fixing member 6 can be fixed on the support plate 5. The fixing member 6 has through holes at its four corners, and threaded holes are arranged at corresponding positions of the support plate 5, and the fixing member 6 can be fixed on the support plate 5 by screws.

[0061] A circular channel is provided on the fixing part 6, and the circular channel is used to fix the monkey's neck collar. A first groove is provided on the fixing part 6 at the rear end of the circular channel, and the first groove runs through the fixing part 6. The first groove is a rectangular groove, and the first groove is connected to the circular channel. The top view of the circular channel is a major arc; a soft cushion is provided in the circular channel.

[0062] Second grooves are arranged at the lower part of both sides of the first groove, and the second grooves are used to clamp the moving member 7 to prevent the monkey from moving around and pushing the moving member 7 away.

[0063] The rear end of the movable member 7 is an operating block, which is a rectangular block. A protrusion is arranged at the front end of the operating block, and an arc block is arranged at the front end of the protrusion. The curvature of the arc block is the same as the curvature of the circular channel on the fixed member 6. The arc block and the circular channel can form a cylindrical channel to fix the collar on the monkey's neck.

[0064] Card plates are respectively arranged at the bottom of the two side surfaces of the raised part, which are adapted to the second groove. The card plates can be inserted into the second groove of the fixing part 6 to ensure the stability of the moving part 7 when sliding, and prevent the monkey from escaping from the device and affecting the progress of the experiment.

[0065] A through hole is arranged on the operating block, and a matching threaded hole is arranged on the supporting plate 5. When the through hole and the threaded hole are coaxial, the arc block and the circular channel can just enclose a cylindrical channel.

[0066] A safety hole is arranged on the support plate 5, and the safety hole is arranged on the support plate 5 at the rear end of the operating block. A safety pin is arranged in the safety hole, which can clamp the moving part 7, and plays a double insurance role to prevent the monkey from pushing the moving part 7 open and escaping.

[0067] A third opening 46 is provided on the rear side of the fixed frame 1, guide grooves 25 are provided on both sides of the third opening 46, a baffle is provided in the guide groove 25, and the baffle is slidably connected to the guide groove 25; a monkey can be put into the fixed frame 1 through the third opening 46, and after being fixed, the baffle is inserted into the guide groove 25 on the side of the third opening 46 to prevent the monkey from escaping, affecting the progress of the experiment or even scratching the experimenter.

[0068] At least one first straight slot hole 41 , at least one second straight slot hole 42 and at least one third straight slot hole 43 are respectively disposed on two side surfaces of the fixing frame 1 .

[0069] Please refer to Figure 5-7 In this embodiment, the non-human primate head fixing device also includes a waist limiter 2, which is arranged inside the fixing frame 1. The waist limiter 2 is movably connected to the fixing frame 1. The upper and lower positions of the waist limiter 2 in the fixing frame 1 are adjustable, and the monkey's waist passes through the waist limiter 2.

[0070] The waist limiter 2 is configured as a rectangular plate, and a fourth opening 47 is configured at the rear end of the waist limiter 2 . The monkey can put the waist limiter 2 into the fourth opening 47 , and the monkey's arms are placed on the waist limiter 2 on both sides of the fourth opening 47 .

[0071] A first fixing plate 33 is set on both sides of the bottom of the waist limiter 2, and the first fixing plate 33 and the waist limiter 2 are fixedly connected. At least one threaded hole is set on the outer side of the first fixing plate 33, and the number of the threaded holes is the same as the first straight slot hole 41. The waist limiter 2 can move up and down along the first straight slot hole 41. A locking piece 38 is set in the first straight slot hole 41, and a threaded rod is set on the locking piece 38. The threaded rod of the locking piece 38 cooperates with the threaded hole to fix the waist limiter 2.

[0072] Please refer to Figure 6-7In this embodiment, the non-human primate head fixing device also includes a seat component 3, which is arranged inside the fixing frame 1. The seat component 3 is arranged at the lower part of the waist limiter 2, and the seat component 3 is movably connected to the fixing frame; the non-human primate can sit on the seat component 3.

[0073] The seat component 3 includes a movable plate 29, a longitudinal plate 30, a seat plate 31 and a back plate 32. Two movable plates 29 and two longitudinal plates 30 are respectively provided; the rear end of the back plate 32 is fixedly connected to the back plate 32, and the two side surfaces of the back plate 32 are respectively fixedly connected to the longitudinal plate 30. The longitudinal plate 30 is perpendicular to the back plate 32, and the upper part of the longitudinal plate 30 is fixedly connected to the movable plate 29, and the movable plate 29 is parallel to the seat plate 31.

[0074] A fifth opening 48 is provided in the middle of the seat plate 31, and the fifth opening 48 divides the seat plate 31 into two parts; the monkey can sit on the seat plate 31, and the fifth opening 48 is used to drain the monkey's feces; a sixth opening is provided on the back plate 32, and the sixth opening is used to extend the monkey's tail to ensure the comfort of the monkey during the experiment.

[0075] A second fixed plate 34 is arranged at the lower part of the movable plate 29, two cylindrical rods are arranged at the bottom of the movable plate 29, and a long hole 49 is arranged on the upper surface of the second fixed plate 34. The two cylindrical rods can be inserted into the long hole 49 and can move along the long hole 49 to adjust the position of the seat component 3.

[0076] At least one threaded hole is arranged on the outer side surface of the second fixing plate 34, and the number of the threaded holes is the same as the second straight slot hole 42. The seat component 3 can move up and down along the second straight slot hole 42. A locking piece 38 is arranged in the second straight slot hole 42, and a threaded rod is arranged on the locking piece 38. The threaded rod of the locking piece 38 cooperates with the threaded hole to fix the seat component 3.

[0077] Please refer to Figure 6 In this embodiment, the fixed frame 1 is also provided with a supporting structure 36, which is arranged at the lower part of the seat component 3. The supporting structure 36 is used to support the monkey's feet. The supporting structure 36 includes a third fixed plate and a connecting rod. Two third fixed plates are provided, and a connecting rod is provided between the two third fixed plates. A plurality of connecting rods are provided. The above arrangement can support the monkey's feet, and the monkey's feces can fall between the connecting rods.

[0078] At least one threaded hole is arranged on the outer side surface of the third fixing plate, and the number of the threaded holes is the same as the third straight slot hole 43. The seat component 3 can move up and down along the third straight slot hole 43. A locking piece 38 is arranged in the third straight slot hole 43, and a threaded rod is arranged on the locking piece 38. The threaded rod of the locking piece 38 cooperates with the threaded hole to fix the seat component 3.

[0079] Please refer to Figure 5-6In this embodiment, a feces receiving portion 37 is further provided in the fixed frame 1, and the feces receiving portion 37 is movably connected to the fixed frame 1. The feces receiving portion 37 is provided at the bottom of the supporting structure 36, and the feces receiving portion 37 is used to receive the feces of the monkeys for easy cleaning.

[0080] The preparation method of the clamp 22 is as follows: a living monkey is selected and anesthetized, and soft plasticine is fixed to the monkey's head. The plasticine covers the entire back of the head to expose the face. The plasticine covers the forehead and both sides of the eyes above the face, and covers the jaw position below the face. After pinching, it is scanned and reconstructed using a 3D printing device to obtain a clamp 22 that fits the monkey's head perfectly.

[0081] Example 2

[0082] In this embodiment, the following specific settings are made for the movement mode of the head fixing member: the adjusting member includes a fixed block 15, a first moving block 16, a second moving block 17 and a lead screw 18; two light rods 19 are arranged between the first moving block 16 and the second moving block 17, the light rod 19 is movably connected to the first moving block 16 and the second moving block 17, the first moving block 16 is fixedly connected to the clamping member 22, a threaded hole adapted to the lead screw 18 is arranged on the first moving block 16, the threaded holes on the first moving block 16 on the first head fixing member and the second head fixing member are in opposite directions, the lead screw 18 passes through the threaded holes on the first moving block 16 on the first head fixing member and the second head fixing member, the lead screw 18 rotates, and the two clamping members 22 approach or move away from each other; the second end of the lead screw 18 passes through the second moving block 17, the lead screw 18 is rotatably connected to the second moving block 17, and the lead screw 18 passes through the fixed block 15 and is rotatably connected to the fixed block 15.

[0083] The device is suitable for the following experimental names: Non-human primate head fixation device;

[0084] Purpose of the experiment: To fix the awake monkeys and combine animal behavior, multimodal electrophysiology, and transcranial electrical / magnetic stimulation to analyze the neural circuit structure and working principles of higher-level cognitive functions and the pathogenic mechanisms of brain diseases.

[0085] The experimental operation steps / process are as follows:

[0086] (1) Pre-experimental monkey treatment: The monkeys of appropriate age were housed in individual cages with movable wall panels. During the experiment, in order to increase the monkeys’ hunger and desire for rewarding food, they were fasted in the morning but had no water restriction.

[0087] (2) Secure the monkey to the non-human primate head fixture: Take the monkey out of the cage, hold the monkey's arms tightly with one hand, hold the monkey's collar tightly with the other hand, push the monkey into the non-human primate head fixture, slowly push the collar into the circular channel of the fixing part of the non-human primate head fixture, push in the moving part, and install the bolts to fix it. After fixing the collar, insert the baffle to prevent the monkey from extending its body or limbs out of the non-human primate head fixture. At the same time, fix the monkey's head.

[0088] (3) Behavioral testing: The non-human primate head fixture was then placed in the Monkey Cantab device, with the monkey facing the screen and about 20 cm away from the screen, so that the monkey could just reach the four corners of the screen and the pellet outlet. Touchscreen training, multiple-choice serial reaction time and other procedures were used to test the monkey's attention and cognitive abilities while awake.

[0089] (4) Physiological signal acquisition: After the monkey is fixed in the non-human primate head fixation device, its head is fixed, and the body and head cannot be turned at will. There is a protective cover in front of the monkey. These precautions prevent the monkey from grabbing the electrodes on the head or transcranial electrical stimulation and transcranial magnetic stimulation equipment. While the monkey is completing the behavioral task, we use a multimodal electrophysiological signal acquisition and intelligent analysis system to collect and analyze the changes in the animal's EEG, electrooculogram, blood oxygen saturation, etc. in different states. We can use electricity / magnetism to accurately stimulate the monkey's target brain area, change the neural activity of the target brain area, detect changes in animal behavior and changes in various physiological signals, and analyze the neural circuit structure and working principle of the advanced cognitive function of human primates, the pathogenic mechanism of brain diseases, etc.

[0090] (5) Put the monkey back into the monkey cage: After the experiment, gently pull the monkey back to the monkey room. Try to avoid scaring the monkey during the transportation process. After arriving at the monkey room, gently lift the non-human primate head fixation device from the trolley, open the baffle at the back of the monkey, remove the moving parts, hold the monkey's arms tightly with one hand and twist them behind its back, hold the monkey's collar with the other hand, take out the moving parts, and then slowly take the collar out of the circular channel of the fixing part of the non-human primate head fixation device, then quickly put the monkey into the monkey cage and quickly close the cage.

[0091] The above embodiments are only used to understand the present invention. It should be noted that, for those skilled in the art, several improvements can be made to the present invention without departing from the principles of the present invention, and these improvements will also fall within the scope of protection of the claims of the present invention.

Claims

1. A head fixing device for non-human primates, characterized in that: It includes: Fixed frame; A head fixing part is arranged on the upper part of the fixing frame, the head fixing part is movably connected to the fixing frame, the head fixing part comprises a first head fixing part and a second head fixing part, the first head fixing part and the second head fixing part are arranged in mirror image, the first head fixing part and the second head fixing part both have a clamping part, the clamping part is adapted to the monkey's head, and the clamping parts on the first head fixing part and the second head fixing part can move closer to or farther from each other, and can clamp or loosen the monkey's head; The fixed frame has a top plate, the interior of the fixed frame is hollow, and a first opening is arranged on the top plate of the fixed frame; the top plate gradually slopes downward from the rear end to the front end; support plates are arranged on both sides of the first opening in a mirror-like manner, and the support plates are fixedly connected to the fixed frame; The first head fixing member further includes a sheet metal member and an adjusting member, wherein the sheet metal member is arranged on a lower side of the top plate, the sheet metal member is movably connected to the top plate, the sheet metal member can move relative to the top plate in the front-rear direction, and the adjusting member is partially arranged in the sheet metal member, and the adjusting member can move up and down in the sheet metal member; The sheet metal part includes a support leg and a bow portion; two support legs are provided, respectively provided on both sides of the bow portion, and the support legs can be fixed on the top plate; a rectangular space is formed in the bow portion, which can accommodate the adjustment member; At least one first slot hole is arranged on the supporting leg, and a threaded hole is arranged at a corresponding position of the top plate, a bolt is arranged in the first slot hole and the threaded hole, and the bolt is tightened in the threaded hole, and the bolt presses the supporting leg and the top plate, so that the sheet metal part and the top plate are fixed; the bow part includes two longitudinal plates and a transverse plate, and the transverse plate is arranged on the top of the longitudinal plate, and the transverse plate fixes the two longitudinal plates; at least one second slot hole is arranged on the longitudinal plate; The adjusting member comprises a fixed block, a first movable block, a second movable block and a lead screw; two light rods are arranged between the first movable block and the second movable block, the light rod is fixedly connected to the first movable block and the second movable block, the first end of the lead screw is arranged in the first movable block, the first end of the lead screw is rotatably connected to the first movable block, the second end of the lead screw passes through the second movable block, the lead screw is rotatably connected to the second movable block, a threaded hole and two through holes are arranged in the fixed block, the lead screw is adapted to the threaded hole in the fixed block, the lead screw passes through the threaded hole in the fixed block, and the light rod passes through the through hole in the fixed block; when the fixed block is fixed, the lead screw is rotated, and the first movable block and the second movable block move along the axial direction of the lead screw; The fixing block is arranged in a rectangular space in the bow portion of the sheet metal part, a threaded hole is arranged on the fixing block, the threaded hole is aligned with the second slot, a bolt is arranged in the threaded hole and the second slot, and when in a loose state, the fixing block moves up and down in the bow portion of the sheet metal part; The operating part is arranged at the second end of the lead screw; the clamping member is fixedly connected to the first moving block, and when the first head fixing member and the second head fixing member are close to each other, a space for fixing the monkey's head can be formed between the clamping members on both sides; The clamping member is provided with a space for placing the monkey's head, and the two clamping members are closed to form a circular space inside, and an observation port is provided at the front end of the clamping member; the first head fixing member and the second head fixing member are mirror-imaged and have the same structure, and the clamping members on both sides are moved closer to or away from each other by rotating the operating parts of the first head fixing member and the second head fixing member; A face shield is arranged at the front end of the top plate, the face shield is fixedly connected to the top plate, and a second opening is arranged in the middle of the face shield; a protruding opening is arranged on the front side of the fixed frame; a third opening is arranged on the rear side of the fixed frame, guide grooves are arranged on both sides of the third opening, a baffle is arranged in the guide groove, and the baffle is slidably connected to the guide groove; the monkey is put into the fixed frame through the third opening, and after being fixed, the baffle is inserted into the guide groove on the side of the third opening.

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