A method for correcting photon beam dose in iodized oil area

Abstract

This invention relates to the field of correction methods, specifically to a photon beam dose correction method for iodized oil regions. It includes the following steps: S1, placing iodized oil samples with different component ratios in a simulation phantom; S2, using a radiotherapy planning system, irradiating the simulation phantom with a photon beam and performing simulated irradiation, respectively obtaining the actual photon beam dose and the simulated photon beam dose; S3, obtaining a photon beam dose correction function based on the corresponding actual and simulated photon beam doses for iodized oil samples with different component ratios; S4, obtaining a photon beam dose correction factor based on the component ratio of the iodized oil samples and the correction function, and determining the correction value for the required dose in the radiotherapy planning system. The relative electron density of an iodized oil sample with a certain component ratio after photon beam irradiation can be obtained, and then the corresponding photon beam dose correction factor can be obtained through the relative electron density.

Description

Technical Field

[0001] The invention relates to the technical field of correction methods, and in particular to a method for correcting photon beam dose in an iodized oil area. Background Art

[0002] Iodized oil is needed during the photon beam test. Iodized oil will be specifically deposited in the cancer tissue and will not disappear during the treatment. However, the presence of iodized oil will affect the actual test dose of the photon beam, resulting in a deviation between the actual test dose of the photon beam and the test dose set by the radiotherapy planning system, which will have an adverse effect on the treatment.

[0003] The existing method is based on the actual required photon beam test dose. When setting the test dose of the radiotherapy planning system, medical staff make corresponding adjustments to the set value based on experience. However, this method is only adjusted based on experience, which has a certain degree of randomness. Sometimes there will be a relatively large deviation between the actual test dose after adjustment and the actually required photon beam test dose. Summary of the invention

[0004] Therefore, the present invention aims to overcome the technical problems in the prior art, thereby providing a relatively scientific method for correcting photon beam dose in the iodized oil area obtained through experiments.

[0005] The present invention provides a method for correcting photon beam dose in an iodized oil region, comprising:

[0006] S1, placing iodized oil samples with different composition ratios in the simulation phantom;

[0007] S2, using a radiotherapy planning system, performing photon beam irradiation and simulated irradiation on the simulation phantom, respectively, to obtain the actual photon beam dose and the photon beam simulated dose;

[0008] S3, obtaining a correction function of the photon beam dose based on the corresponding actual photon beam dose and the photon beam simulated dose under the iodized oil samples with different component ratios;

[0009] S4, based on the composition ratio of the iodized oil sample and the correction function, a photon beam dose correction factor is obtained to determine a correction value of the required dose in the radiotherapy planning system.

[0010] Furthermore, in the step S2, the irradiation doses of the photon beam irradiation and the simulated irradiation are the same.

[0011] Furthermore, in step S2, a CT image is obtained by performing a CT scan on the simulation phantom, and the radiotherapy planning system simulates irradiation on the CT image.

[0012] Furthermore, the photon beam simulated dose is characterized by the relative electron density on the CT image after simulated irradiation.

[0013] Furthermore, the step S3 includes:

[0014] S31, performing function fitting on the corresponding relative electron density based on the component ratio of the iodized oil sample to obtain a fitting function of the relative electron density;

[0015] S32, calculating the deviation ratio between the actual dose of the photon beam and the simulated dose of the photon beam under the iodized oil samples with different component ratios;

[0016] S33, based on the relative electron density corresponding to the iodized oil samples with different component ratios, function fitting is performed on each obtained deviation ratio, and the obtained deviation ratios are calibrated as correction functions.

[0017] Furthermore, in step S32, the deviation ratio is calculated by a deviation calculation formula, and the deviation calculation formula is as follows:

[0018] δ=(D real -D TPS ) / D TPS *100%,

[0019] Among them, δ is the deviation ratio, D real is the actual dose of the photon beam, D TPS Simulate the dose for the photon beam.

[0020] Further, the step S4 includes:

[0021] S41, based on the component ratio of the iodized oil sample, substituting into the fitting function of the relative electron density to obtain the corresponding relative electron density;

[0022] S42, substituting the obtained relative electron density into the correction function to obtain a photon beam dose correction factor;

[0023] S43, based on the required dose and correction factor in the radiotherapy planning system, and the deviation calculation formula, calculate the correction value of the required dose in the radiotherapy planning system, wherein the correction factor is substituted into the deviation ratio, and the required dose is substituted into the actual dose of the photon beam.

[0024] A device for correcting photon beam dose in an iodized oil area, comprising:

[0025] A test module, used to place iodized oil samples with different composition ratios in a simulation model;

[0026] An irradiation module is used to use a radiotherapy planning system to perform photon beam irradiation and simulated irradiation on the simulation phantom, respectively, to obtain a determined actual dose of the photon beam and a simulated dose of the photon beam;

[0027] A calculation module, used for obtaining a correction function of the photon beam dose based on the corresponding actual dose of the photon beam and the simulated dose of the photon beam under the iodized oil samples with different component ratios;

[0028] The correction module is used to obtain the photon beam dose correction factor based on the component ratio of the iodized oil sample and the correction function, and determine the correction value of the required dose in the radiotherapy planning system.

[0029] A terminal device comprises a memory and a processor, wherein the memory stores a computer program that can be run on the processor, and when the processor executes the computer program, the above-mentioned method for correcting photon beam dose in an iodized oil area is implemented.

[0030] A computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the above-mentioned method for correcting photon beam dose in an iodized oil area is implemented.

[0031] The technical solution of the present invention has the following advantages:

[0032] The present invention provides a method for correcting photon beam dose in an iodized oil area, which establishes a functional relationship between the actual dose of the photon beam and the simulated dose of the photon beam, and then obtains the correction value of the required dose by obtaining the photon beam dose correction factor, and has relatively high scientificity and accuracy.

[0033] The present invention provides a method for correcting photon beam dose in the lipiodol area, which can obtain the relative electron density of a lipiodol sample with a certain component ratio after being irradiated with a photon beam, and then obtain the corresponding photon beam dose correction factor through the relative electron density. real -D TPS ) / D TPS *100%, the photon beam dose correction factor δ can be determined by the above, and the actual required photon beam test dose is D real , we can calculate D TPS The present application obtains the relationship between the composition ratio of the iodized oil sample and the corresponding relative electron density, as well as the relationship between the relative electron density and the corresponding photon beam dose correction factor through an experimental method, which has relatively high scientificity and accuracy. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0035] Figure 1 It is a schematic diagram of the principle of the present invention;

[0036] Figure 2 It is a schematic diagram of the principle of the present invention;

[0037] Figure 3 It is a schematic diagram of the principle of the present invention;

[0038] Figure 4 The figure is a schematic diagram of the preparation of the iodized oil sample and the simulation model of the present invention;

[0039] Figure 5 This is a coronal image of a CT scan of the abdominal simulation phantom after the sample tube is inserted into the present invention;

[0040] Figure 6 RED calibration fitting curve diagram of lipiodol samples with different mixing ratios of the present invention;

[0041] Figure 7 It is a fitting curve diagram of different RED and photon beam dose correction factor δ of the present invention. DETAILED DESCRIPTION

[0042] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0043] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0044] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0045] In addition, the technical features involved in the different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0046] Example

[0047] This example uses liver cancer as an example. Liver cancer is the sixth most common malignant tumor and the third leading cause of cancer-related death in the world, causing 830,000 deaths each year. In my country, liver cancer ranks fourth in incidence and second in mortality. Hepatocellular carcinoma is the most common histological type of primary liver cancer, accounting for 75%-85% (1). Liver cancer has an insidious onset. 64% of patients in my country are already in the middle and late stages at the time of initial diagnosis. Transcatheter arterial chemoembolization (TACE) is an important treatment method. For patients with hepatocellular carcinoma in BCLC stage B, with good liver function and no macroscopic vascular invasion or extrahepatic spread, TACE is currently considered the first-line treatment. However, TACE is not a radical treatment for most patients. The comprehensive treatment of TACE combined with trials can significantly improve the efficacy of patients. Meta-analysis shows that compared with simple intervention, the objective response rate (ORR) of interventional combined trials is significantly improved, and the median survival period is extended from 13.5 months to 22.7 months.

[0048] After interventional surgery, iodized oil is specifically deposited in hepatocellular carcinoma tissue and does not disappear during the treatment process, resulting in an increase in the Hounsfield unit (HU) of the tumor area in the CT image. In photon radiotherapy, the radiotherapy planning system (TPS) calculates the dose distribution based on the conversion of the HU value of the CT image into relative electron density (RED). Therefore, the increase in the HU value in the iodized oil area will change the RED, resulting in a change in the dose distribution. DONGHO SHIN et al. evaluated the effect of iodized oil on the irradiation depth of the proton test beam and found that the high HU value in the iodized oil area will lead to a deeper actual beam depth of proton therapy. TPS will overestimate the blocking ability of iodized oil on the proton beam, resulting in the actual dose delivered to the tumor area and organs at risk (OAR) being significantly greater than the planned dose. Scherman et al. measured the iodine-containing liquid marker used in lung proton radiotherapy and found that the iodized oil marker can cause a 4.8% dose disturbance. In photon radiotherapy, whether TPS directly calculates the photon dose based on the converted RED is accurate, and the dosimetric effect of the lipiodol precipitation area on the photon beam needs further study. In addition, previous studies have directly used pure lipiodol, and it is very necessary to design a system of lipiodol areas with different densities to simulate liver tumor intervention for clinical research. Based on the dosimetric effect of the lipiodol precipitation area on the photon beam, an estimate can be made when setting the photon beam test dose in the radiotherapy planning system.

[0049] like Figures 1 to 7 A method for correcting photon beam dose in an iodized oil area is shown, comprising:

[0050] S1, placing iodized oil samples with different composition ratios in the simulation phantom;

[0051] S2, using a radiotherapy planning system, performing photon beam irradiation and simulated irradiation on the simulation phantom, respectively, to obtain the actual photon beam dose and the photon beam simulated dose;

[0052] S3, obtaining a correction function of the photon beam dose based on the corresponding actual photon beam dose and the photon beam simulated dose under the iodized oil samples with different component ratios;

[0053] S4, based on the composition ratio of the iodized oil sample and the correction function, a photon beam dose correction factor is obtained to determine a correction value of the required dose in the radiotherapy planning system.

[0054] In step S1, the iodized oil sample can be prepared by mixing iodized oil and minced pig liver. Specifically, the iodized oil sample can be prepared by mixing uniformly minced pig liver and iodized oil injection in six different proportions, wherein the mixing proportions are 0ml / 100g, 2ml / 100g, 5ml / 100g, 10ml / 100g, 15ml / 100g, and 20ml / 100g.

[0055] The iodized oil samples with different composition ratios can be respectively placed in corresponding sample chambers, and then the sample chambers containing the iodized oil samples are inserted into a simulation phantom; the simulation phantom can be an abdominal simulation phantom. A CT scanner is used to perform CT scanning on the simulation phantom to obtain a CT image.

[0056] Two adjacent sample chambers are detachably connected, and multiple sample chambers are sequentially connected to form a sample tube. The capacity of each sample chamber can be about 60ml.

[0057] An ionization chamber channel is provided through the middle of the sample tube, which is convenient for CT scanning and dose measurement. The sample chamber is made of PE material, and the sample chambers in the sample tube are sealed.

[0058] Furthermore, in the step S2, the irradiation doses of the photon beam irradiation and the simulated irradiation are the same.

[0059] Furthermore, in step S2, a CT image is obtained by performing a CT scan on the simulation phantom, and the radiotherapy planning system simulates irradiation on the CT image.

[0060] Furthermore, the photon beam simulated dose is characterized by the relative electron density on the CT image after simulated irradiation.

[0061] Furthermore, the step S3 includes:

[0062] S31, performing function fitting on the corresponding relative electron density based on the component ratio of the iodized oil sample to obtain a fitting function of the relative electron density;

[0063] S32, calculating the deviation ratio between the actual dose of the photon beam and the simulated dose of the photon beam under the iodized oil samples with different component ratios;

[0064] S33, based on the relative electron density corresponding to the iodized oil samples with different component ratios, function fitting is performed on each obtained deviation ratio, and the obtained deviation ratios are calibrated as correction functions.

[0065] Furthermore, in step S32, the deviation ratio is calculated by a deviation calculation formula, and the deviation calculation formula is as follows:

[0066] δ=(D real -D TPS ) / D TPS *100%,

[0067] Among them, δ is the deviation ratio, D real is the actual dose of the photon beam, D TPS Simulate the dose for the photon beam.

[0068] Further, the step S4 includes:

[0069] S41, based on the component ratio of the iodized oil sample, substituting into the fitting function of the relative electron density to obtain the corresponding relative electron density;

[0070] S42, substituting the obtained relative electron density into the correction function to obtain a photon beam dose correction factor;

[0071] S43, based on the required dose and correction factor in the radiotherapy planning system, and the deviation calculation formula, calculate the correction value of the required dose in the radiotherapy planning system, wherein the correction factor is substituted into the deviation ratio, and the required dose is substituted into the actual dose of the photon beam.

[0072] Specifically, the CT image is imported into the radiotherapy planning system, and the radiotherapy planning system performs photon beam simulation irradiation on the imported CT image to obtain the photon beam simulation dose. The iodized oil area, ionization chamber detector and normal tissue organs (OARs) are outlined on the CT images of the iodized oil samples with different mixing ratios. In this embodiment, a fixed 6MV X-ray, different segmentation modes (1Gy / f-10Gy / f) and a uniform block mode (FF / FFF) can be used in the radiotherapy planning system to simulate the irradiation of iodized oil areas of different densities in turn, and the photon beam simulation dose D of the current radiotherapy planning system is recorded. TPS, where the photon beam simulated dose is the Hu value on the CT image. The radiotherapy planning system can convert the photon beam simulated dose D through the HU-RED conversion relationship. TPS It should be noted that the radiotherapy planning system simulates the photon beam irradiation of the imported CT image, and multiple simulated irradiations will not affect the CT image, meeting the requirements of the control variable.

[0073] In the present embodiment, in order to avoid the difference in HU value definition between different CT scanners and radiotherapy planning systems, the present application has carried out accurate electron density calibration for lipiodol samples of different mixing ratios. This calibration density will be used as a standard reference for subsequent research. The sample bins containing lipiodol samples are assembled in groups of three and inserted into the base of the abdomen simulation model; the ionization chamber detectors are placed at the centers of the 6 sample bins respectively, and a spiral CT scan (Siemens SOMATOM Definition AS CT) of 1 mm per layer is performed, with a scanning voltage of 120 kV and a current of 300 mA. The scanned image ( Figure 5 ) was uploaded to the radiotherapy planning system (Pinnacle3 V16.2) used by our unit, and the RED of each group of iodized oil samples with different mixing ratios was calibrated based on the HU-RED conversion relationship used by the radiotherapy planning system, where RED is the relative electron density in this application.

[0074] Figure 4 The present invention is the preparation of iodized oil samples and a simulation model, wherein A is 100g of uniformly minced pig liver equivalent to human liver tissue; B is 2ml, 5ml, 10ml, 15ml and 20ml of Lipodol iodized oil injection; C is iodized oil samples with a mixing ratio of 0ml / 100g, 2ml / 100g, 5ml / 100g, 10ml / 100g, 15ml / 100g and 20ml / 100g after being filled into sample tubes, and each group of three is assembled; D is a design drawing of an assembleable cylindrical sample tube, with an ionization chamber channel reserved in the middle; E is a real picture of an unassembled sample tube; F is a schematic diagram of an abdominal simulation model; and G is a real picture of the abdominal simulation model after the sample tube is inserted.

[0075] Figure 5 This is a coronal CT scan of the abdominal simulation model after the sample tube was inserted: Figure A shows 0ml / 100g, 2ml / 100g, and 5ml / 100g iodized oil samples from bottom to top, and the ionization chamber detector is located at the center of the 2ml / 100g sample tube; Figure B shows 10ml / 100g, 15ml / 100g, and 20ml / 100g iodized oil samples from bottom to top, and the ionization chamber detector is located at the center of the 15ml / 100g sample tube.

[0076] Furthermore, an ionization chamber detector is inserted into the ionization chamber channel to obtain an actual dose relative to the electron density.

[0077] The linear accelerator was used to irradiate the abdomen simulation phantom with the sample tube inserted with the same beam as TPS. The ionization chamber charge number at the center of each sample chamber was read by the ionization chamber detector, the relative electron density in each mode was recorded, and the actual dose D of the photon beam was obtained through the HU-RED conversion relationship. real . Set the D TPS and D real By comparison, the relationship between the photon beam dose correction factor δ and the iodized oil deposition area RED is obtained, wherein the calculation formula of the photon beam dose correction factor δ is as follows:

[0078] δ=(D real -D TPS ) / D TPS *100%.

[0079] The relationship between the photon beam dose correction factor δ and the RED of the iodized oil area was obtained under different fractionation modes (1Gy / f–10Gy / f) and uniform block mode (FF / FFF). The calibration fitting curves of the RED of iodized oil samples with different mixing ratios are shown in Figure 2. Figure 6 As shown (R2 = 0.9994). Among them, the RED of the 0ml / 100g sample without iodized oil is 1.062g / cm3, which is close to the RED of normal human liver tissue (1.05-1.07g / cm3) (14), indicating that the method of this example is in line with the actual situation.

[0080] Figure 6 The RED calibration fitting curves of the iodized oil samples with different mixing ratios used are shown in Figure 1. The linearity of the calibration curve is R2=0.9994, and the remaining density values ​​are calculated using the linear interpolation method.

[0081] The iodized oil area D at different REDs under different fractionation modes (1Gy / f–10Gy / f) and uniform block mode (FF / FFF) TPS and D real The photon beam dose correction factor δ is as follows Figure 7 As shown. The photon beam dose correction factor δ of the 0ml / 100g sample without iodized oil is close to 0 (μ±σ=0.06%±0.04%, μ is the mean value, σ is the standard deviation), that is, without considering the influence of the iodized oil area, the accuracy of the TPS calculation results and the actual measurement results is verified. Under the fixed segmentation and homogenization block mode, as the iodized oil content increases, the δ value also gradually increases (range is 0.54% to 5.74%, P<0.0001), indicating that TPS will underestimate the dose calculation results of the iodized oil area in photon radiotherapy.

[0082] Figure 7 The fitting curves of different RED and photon beam dose correction factor δ under different segmentation modes (1Gy / f–10Gy / f) and uniform block mode (FF / FFF) (average linearity R2=0.9985 in FF mode, average linearity R2=0.9975 in FFF mode) are shown. The remaining photon beam dose correction factors δ are calculated using linear interpolation method. Figure 7 It can be seen that under the fixed segmentation and homogenization block modes, as the iodized oil content increases, the δ value gradually increases (ranging from 0.54% to 5.74%, P<0.0001), indicating that the radiotherapy planning system will underestimate the dose calculation results of the iodized oil area. Under the same segmentation mode, the correction factor δFFF in the FFF mode is systematically higher than the correction factor δFF in the FF mode (δFF ranges from 0.27% to 4.31%, and δFFF ranges from 0.54% to 5.74%, P<0.0001). The formula δ=(D real -D TPS ) / D TPS *100%, the actual required photon beam test dose is D real Make corrections.

[0083] Through the above experiments, the relative electron density of the iodized oil sample with a certain composition ratio after photon beam irradiation can be obtained, and then the corresponding photon beam dose correction factor can be obtained through the relative electron density. When making an estimate, based on the formula δ=(D real -D TPS ) / D TPS *100%, the photon beam dose correction factor δ can be determined by the above, and the actual required photon beam test dose is D real , we can calculate D TPS , because this method obtains the relationship between the composition ratio of the iodized oil sample and the corresponding relative electron density by function fitting, and obtains the relationship between the relative electron density and the corresponding photon beam dose correction factor by function fitting.

[0084] A device for correcting photon beam dose in an iodized oil area, comprising:

[0085] A test module, used to place iodized oil samples with different composition ratios in a simulation model;

[0086] An irradiation module is used to use a radiotherapy planning system to perform photon beam irradiation and simulated irradiation on the simulation phantom, respectively, to obtain a determined actual dose of the photon beam and a simulated dose of the photon beam;

[0087] A calculation module, for obtaining a correction function of the photon beam dose based on the corresponding actual photon beam dose and the photon beam simulated dose under iodized oil samples with different component ratios;

[0088] The correction module is used to obtain the photon beam dose correction factor based on the component ratio of the iodized oil sample and the correction function, and determine the correction value of the required dose in the radiotherapy planning system.

[0089] A terminal device comprises a memory and a processor, wherein the memory stores a computer program that can be run on the processor, and when the processor executes the computer program, the above-mentioned method for correcting photon beam dose in an iodized oil area is implemented.

[0090] A computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the above-mentioned method for correcting photon beam dose in an iodized oil area is implemented.

[0091] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the invention.

Claims

1. A method for correcting photon beam dose in lipiodol area, characterized in that: include: S1, placing iodized oil samples with different composition ratios in the simulation phantom; S2, using a radiotherapy planning system, performing photon beam irradiation and simulated irradiation on the simulation phantom, respectively, to obtain the actual photon beam dose and the photon beam simulated dose; S3, obtaining a correction function of the photon beam dose based on the corresponding actual photon beam dose and the photon beam simulated dose under the iodized oil samples with different component ratios; S4, based on the composition ratio of the iodized oil sample and the correction function, a photon beam dose correction factor is obtained to determine a correction value of the required dose in the radiotherapy planning system; The step S3 comprises: S31, performing function fitting on the corresponding relative electron density based on the component ratio of the iodized oil sample to obtain a fitting function of the relative electron density; S32, calculating the deviation ratio between the actual dose of the photon beam and the simulated dose of the photon beam under the iodized oil samples with different component ratios; S33, performing function fitting on each obtained deviation ratio based on the relative electron density corresponding to the iodized oil samples with different component ratios, and calibrating them into a correction function; The step S4 comprises: S41, based on the component ratio of the iodized oil sample, substituting into the fitting function of the relative electron density to obtain the corresponding relative electron density; S42, substituting the obtained relative electron density into the correction function to obtain a photon beam dose correction factor; S43, based on the required dose and correction factor in the radiotherapy planning system, and the deviation calculation formula, calculate the correction value of the required dose in the radiotherapy planning system, wherein the correction factor is substituted into the deviation ratio, and the required dose is substituted into the actual dose of the photon beam.

2. The lipiodol area photon beam dose correction method according to claim 1, wherein: In the step S2, the irradiation doses of the photon beam irradiation and the simulated irradiation are the same.

3. The lipiodol area photon beam dose correction method according to claim 1, wherein: In the step S2, a CT image is obtained by performing a CT scan on the simulation phantom, and the radiotherapy planning system simulates irradiation on the CT image.

4. The lipiodol area photon beam dose correction method according to claim 3, wherein: The simulated dose of the photon beam is characterized by the relative electron density on the CT image after simulated irradiation.

5. The lipiodol area photon beam dose correction method according to claim 1, characterized in that: In step S32, the deviation ratio is calculated by a deviation calculation formula, and the deviation calculation formula is as follows: δ=(D real -D TPS ) / D TPS *100%, Among them, δ is the deviation ratio, D real is the actual dose of the photon beam, D TPS Simulate the dose for the photon beam.

6. A lipiodol area photon beam dose correction device, applicable to the lipiodol area photon beam dose correction method as described in any one of claims 1 to 5, characterized in that: include: A test module, used to place iodized oil samples with different composition ratios in a simulation model; An irradiation module is used to use a radiotherapy planning system to perform photon beam irradiation and simulated irradiation on the simulation phantom, respectively, to obtain a determined actual dose of the photon beam and a simulated dose of the photon beam; A calculation module, for obtaining a correction function of the photon beam dose based on the corresponding actual photon beam dose and the photon beam simulated dose under iodized oil samples with different component ratios; The correction module is used to obtain the photon beam dose correction factor based on the component ratio of the iodized oil sample and the correction function, and determine the correction value of the required dose in the radiotherapy planning system.

7. A terminal device, comprising a memory and a processor, wherein the memory stores a computer program that can be run on the processor, characterized in that: When the processor executes the computer program, the method for correcting photon beam dose in the lipiodol area according to any one of claims 1 to 5 is implemented.

8. A computer-readable storage medium storing a computer program, characterized in that: When the computer program is executed by a processor, the method for correcting photon beam dose in the lipiodol area according to any one of claims 1 to 5 is implemented.

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