An intelligent biological sample analyzer

Abstract

The present invention relates to an intelligent biological sample analyzer, comprising an instrument body, a box slot, a sample tray, a reagent tube, a driving shaft, a test tube wheel, a top convex angle, a test tube block and a connecting piece. When adding a new reagent to a sample, the present invention allows an experimenter to directly add the new reagent into a placed reagent tube without taking out the reagent tube in advance, and then the driving shaft drives the test tube wheel to rotate forward, and the top convex angle on the test tube wheel drives the reagent tube to rotate and lift, and then the position is quickly restored under the elastic force of the connecting piece, so that the reagent tube is shaken to evenly shake the sample and the reagent, effectively reducing the workload of frequently taking out and putting in the reagent tube, thereby improving the sample analysis efficiency. When the driving shaft drives the test tube wheel to rotate in the opposite direction, the top convex angle pushes the reagent tube outward, so that the reagent tube extends out of the placement hole, which is convenient for taking the reagent tube, thereby further improving the sample analysis efficiency.

Description

Technical Field

[0001] The present invention relates to a sample analyzer, in particular to an intelligent biological sample analyzer applied in the field of biological analysis technology. Background Art

[0002] Biological samples usually refer to the flowers, leaves, stems, roots, seeds, etc. of plants, the body fluids, hair, muscles, tissues and organs of animals, and various microorganisms. Biological samples are extracted and placed in test tubes for biological analysis in combination with detection reagents.

[0003] The specification of Chinese invention patent CN202222987388.1 discloses "A biological sample analysis instrument". This patent is designed with a lifting plate and a lifting groove. When the sample storage disk is rotated to the outside, the reagent tube in the tube hole is pushed out by the lifting plate to facilitate the user to take it. At the same time, a clamping plate is provided inside to make the reagent tube rotated to the inside be clamped inside.

[0004] In the above patent and the existing analyzer, when analyzing biological samples, the biological samples are first placed in a test tube, and then the test tube containing the sample is placed in the analyzer. The analysis of biological samples requires the use of special analytical reagents, which include various types. When performing multiple reagent analyses, the test tube containing the sample will have reagents added multiple times. Therefore, the sample test tube needs to be frequently accessed on the analyzer. The analyzer has a large amount of test tube access operations, and the sample test tube needs to be shaken after a new reagent is added. The workload of biological sample analysis is further increased, affecting the efficiency of sample analysis. Summary of the invention

[0005] In view of the above-mentioned prior art, the technical problem to be solved by the present invention is that when biological samples are analyzed with multiple reagents, sample tubes need to be frequently accessed and stored on the analyzer, and the sample tubes need to be shaken after a new reagent is added. The workload of biological sample analysis is large, which affects the efficiency of sample analysis.

[0006] In order to solve the above problems, the present invention provides an intelligent biological sample analyzer, including an instrument body, one end of the instrument body is fixedly connected to a box slot, the top of the box slot is fixedly connected to a box cover, the middle of the box cover is fixedly connected to a sample tray, and reagent tubes are placed inside the sample tray; a driving shaft is rotatably connected to the inside of the box slot, a test tube wheel is sleeved on the outside of the driving shaft, the bottom of the reagent tube touches the outer surface of the test tube wheel, the outer surface of the test tube wheel is fixedly connected to a top convex angle, the top convex angle corresponds to the bottom of the reagent tube, a test tube block is fixedly connected to the middle of the sample tray, both ends of the test tube block are fixedly connected to connecting pieces, the connecting piece is fixedly connected to the inner wall of the sample tray, a placement hole is opened in the middle of the test tube block, and the reagent tube is sleeved in the placement hole.

[0007] In the above-mentioned intelligent biological sample analyzer, after adding new reagents directly to the reagent tubes on the sample tray, the sample tray is then used to drive the test tube wheel to rotate, and the top convex corners on the test tube wheel resist the bottom rotation of the reagent tube, causing the connecting piece to bend more severely. Subsequently, the top convex corners are out of contact with the reagent tube, and the connecting piece drives the test tube block to quickly reset the reagent tube, so that the reagent tube is shaken to evenly shake the sample and reagent. The reagent tube does not need to be taken out of the analyzer, which effectively reduces the workload of biological sample analysis, thereby improving analysis efficiency.

[0008] As a further improvement of the present application, the top convex corner is arranged in a fin shape, and the arc surface and the flat surface of the top convex corner both correspond to the bottom of the test tube block, when the arc surface of the top convex corner rotates to contact the bottom of the reagent tube, it drives the reagent tube to rotate slowly, and the subsequent reagent tube quickly recovers from the flat surface, thereby achieving the shaking and even shaking of the reagent tube, and when the flat surface of the top convex corner rotates to contact the bottom of the reagent tube, the top convex corner pushes the reagent tube outward, making it easier to take the reagent tube.

[0009] As a further improvement of the present application, the connecting piece is bent in a U shape and is made of an elastic plastic sheet. The outer surface of the sample tray is covered with an outer coating, and the upper surface of the test tube block is fixedly connected to the outer coating. When the reagent tube is rotated and pushed, the U-shaped bent connecting piece is deformed accordingly. Subsequently, the elastic force of the connecting piece is used to drive the test tube block to restore the position of the reagent tube, thereby achieving the effect of shaking the reagent tube to evenly shake the sample and reagent. The outer coating covers the exposed test tube block to effectively close the gap between the test tube block and the sample tray.

[0010] As a further improvement of the present application, a membrane hole sleeve is fixedly connected to the placement hole corresponding to the outer membrane surface, and the membrane hole sleeve is inserted into the placement hole. A fan gasket is fixedly connected to the inside of the membrane hole sleeve, and the fan gasket is made of rubber material. The membrane hole sleeve cooperates with the fan gasket to achieve the sealing of the placement hole, effectively preventing external dust from entering the analyzer. At the same time, when the reagent tube is inserted into the placement hole, the fan gasket tightens the reagent tube, effectively improving the placement stability of the reagent tube.

[0011] As another improvement of the present application, the inner ring of the test tube wheel is fixedly embedded with a magnetic block, which corresponds to the adsorption of the drive shaft. The magnetic block is made of magnet material. Through the adsorption of the magnetic block and the drive shaft, the test tube wheel is driven by the rotation of the drive shaft, effectively improving the transmission flexibility between the test tube wheel and the drive shaft.

[0012] As another improved supplement of the present application, the bottom of the box slot is fixedly connected to a fixed rail, the top of the fixed rail is movably connected to a tooth plate, both ends of the test tube wheel are fixedly connected to a gear ring, the tooth plate is meshed with the gear ring, and the gear ring is meshed and locked by the tooth plate, thereby achieving separate locking of a specified test tube wheel, thereby distinguishing the working states of different test tube wheels.

[0013] As another improvement supplement of the present application, an electromagnet sheet is fixedly embedded on the upper surface of the fixed rail, and a magnet bar is fixedly embedded on the lower surface of the tooth plate. The magnetic forces of the electromagnet sheet and the magnet bar repel each other, and the magnetic force generated by energizing the electromagnet sheet repels the magnet bar, thereby causing the tooth plate to rise, making it easier for the tooth plate to mesh and lock the gear ring.

[0014] As another improvement of the present application, both ends of the bottom of the tooth plate are fixedly connected with pad strips, and the surface of the pad strips is provided with insertion holes. Both ends of the top of the fixed rail are slidably connected with movable bars, and the bottom of the movable bar is fixedly connected with plug posts, which are plug-in corresponding to the insertion holes. When the tooth plate rises due to the repulsive force, the plug posts are inserted into the insertion holes, so that the tooth plate is locked after rising, thereby effectively improving the stability of the tooth plate.

[0015] As another improvement supplement of the present application, the bottom of the fixed rail is slidably connected with an electric slider, which is fixedly connected to the movable bar. The electric slider drives the movable bar to move, thereby realizing horizontal movement of the tooth plate, and drives the gear ring through meshing to realize the independent reverse rotation of the test tube wheel.

[0016] As another improvement supplement to the present application, a top block is slidably connected to one end of the top of the fixed rail away from the electric slider, one end of the top block is movably connected to the tooth plate, and a reset spring is fixedly connected between the other end of the top block and the inner wall of the box groove. The electric slider drives the tooth plate to move toward the top block, squeezing the reset spring, and subsequently the tooth plate is restored to its position under the elastic force of the reset spring.

[0017] In summary, the present invention places the reagent tube containing the sample into the placement hole on the test tube block for analysis and detection. When adding new reagent to the sample, the reagent is directly added into the placed reagent tube, and then the driving shaft drives the test tube wheel to rotate forward. The top convex corner on the test tube wheel pushes the reagent tube to rotate and lift, and then the position is quickly restored under the elastic force of the connecting piece, so that the reagent tube is shaken to evenly shake the sample and the reagent. The reagent tube does not need to be taken out of the analyzer, which effectively reduces the workload of biological sample analysis, thereby improving the analysis efficiency. When the driving shaft drives the test tube wheel to rotate in the opposite direction, the top convex corner pushes the reagent tube outward, so that the reagent tube extends out of the placement hole, which is convenient for taking the reagent tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a three-dimensional structural diagram of the test tube wheel and the fixed rail in the first embodiment of the present application;

[0019] Figure 2 This is a three-dimensional structural diagram of the first embodiment of the present application;

[0020] Figure 3 This is a top-down perspective structural diagram of a box slot in the first embodiment of the present application;

[0021] Figure 4This is a demonstration diagram of the forward rotation of the test tube wheel in the first embodiment of the present application;

[0022] Figure 5 This is a demonstration diagram of the reverse rotation of the test tube wheel in the first embodiment of the present application;

[0023] Figure 6 This is a three-dimensional structural diagram of a test tube wheel according to the first embodiment of the present application;

[0024] Figure 7 This is a three-dimensional structural diagram of a sample tray according to the first embodiment of the present application;

[0025] Figure 8 This is a three-dimensional structural diagram of a test tube block according to the first embodiment of the present application;

[0026] Fig. 9 This is a three-dimensional structural diagram of the outer coating of the first embodiment of the present application;

[0027] Fig.10 This is a cross-sectional illustration of the lifting change of the latch plate in the second embodiment of the present application;

[0028] Fig.11 This is a bottom-up stereoscopic structural diagram of the fixed rail and the latch plate according to the second embodiment of the present application.

[0029] Description of the numbers in the figure:

[0030] 1. Instrument body; 101. Box slot; 102. Box cover; 2. Sample tray; 201. Test tube block; 202. Connecting piece; 203. Placement hole; 204. Outer film; 205. Film hole sleeve; 206. Fan gasket; 3. Reagent tube; 4. Driving shaft; 401. Test tube wheel; 402. Top convex corner; 403. Magnetic block; 5. Fixed rail; 501. Gear plate; 502. Gear ring; 503. Electromagnet sheet; 504. Magnet strip; 6. Pad strip; 601. Socket; 602. Movable strip; 603. Plug column; 604. Electric slider; 605. Top block; 606. Reset spring. DETAILED DESCRIPTION

[0031] Two implementation modes of the present application are described in detail below with reference to the accompanying drawings.

[0032] The first implementation method:

[0033] Figure 1-6FIG. 1 shows an intelligent biological sample analyzer, comprising an instrument body 1, wherein one end of the instrument body 1 is fixedly connected to a box slot 101, a box cover 102 is fixedly connected to the top of the box slot 101, a sample tray 2 is fixedly connected to the middle of the box cover 102, and a reagent tube 3 is placed inside the sample tray 2; a driving shaft 4 is rotatably connected to the inside of the box slot 101, a test tube wheel 401 is sleeved on the outside of the driving shaft 4, the bottom of the reagent tube 3 touches the outer surface of the test tube wheel 401, a top convex angle 402 is fixedly connected to the outer surface of the test tube wheel 401, the top convex angle 402 corresponds to the bottom of the reagent tube 3, the top convex angle 402 is fin-shaped, and the arc surface and the flat surface of the top convex angle 402 are both in contact with the top convex angle 402. The bottom of the test tube block 201 corresponds to that of the test tube block 201. When the arc surface of the top convex angle 402 rotates and contacts the bottom of the reagent tube 3, it drives the reagent tube 3 to rotate slowly. Subsequently, the reagent tube 3 quickly recovers from the flat surface, thereby achieving the shaking and even shaking of the reagent tube 3. When the flat surface of the top convex angle 402 rotates and contacts the bottom of the reagent tube 3, the top convex angle 402 pushes the reagent tube 3 outward, making it easier to take the reagent tube 3. The middle of the sample tray 2 is fixedly connected with the test tube block 201, and both ends of the test tube block 201 are fixedly connected with connecting pieces 202. The connecting piece 202 is fixedly connected to the inner wall of the sample tray 2. A placement hole 203 is opened in the middle of the test tube block 201, and the reagent tube 3 is sleeved with the placement hole 203.

[0034] When the analyzer is analyzing biological samples, the sample to be analyzed is placed in the reagent tube 3, and the reagent tube 3 is inserted into the test tube block 201 on the sample tray 2. The analyzer analyzes the sample in the reagent tube 3. When analyzing a new reagent, the experimenter directly places the reagent into the previously placed reagent tube 3, and then operates the drive shaft 4 to drive the test tube wheel 401 to rotate forward. The forward rotation refers to the arc surface of the top convex corner 402 rotating to contact the bottom of the reagent tube 3. The reagent tube 3 is pushed by the top convex corner 402 and slowly lifted up, and then the reagent tube 3 is elastically pulled up by the connecting piece 202. Rapid position restoration realizes shaking of the reagent tube 3 to achieve uniform mixing of the sample and the reagent. During the mixing process, the reagent tube 3 does not need to be taken out, which effectively reduces the frequent storage and retrieval of the test tube, thereby effectively improving the analysis efficiency of biological samples. After the sample analysis is completed, the operating drive shaft 4 drives the test tube wheel 401 to rotate in the opposite direction. Reverse rotation refers to the rotation of the flat surface of the top convex angle 402 to contact the bottom of the reagent tube 3. At this time, the reagent tube 3 is no longer lifted and rotated, but is pushed to move outside the placement hole 203, so that the reagent tube 3 can extend out of the placement hole 203, thereby facilitating the extension of the reagent tube 3.

[0035] Figure 7-9As shown, the connecting piece 202 is bent in a U shape, and the connecting piece 202 is made of an elastic plastic sheet. The outer surface of the sample tray 2 is paved with an outer coating 204, and the upper surface of the test tube block 201 is fixedly connected to the outer coating 204. When the reagent tube 3 is rotated and pushed, the U-shaped bent connecting piece 202 is deformed accordingly. Subsequently, the elastic force of the connecting piece 202 is used to drive the test tube block 201 to restore the position of the reagent tube 3, so that the reagent tube 3 is shaken to evenly shake the sample and the reagent. The outer coating 204 covers the exposed test tube block 201, effectively sealing the test tube 3. The gap between the tube block 201 and the sample tray 2, the surface of the outer film 204 is fixedly connected with a membrane hole sleeve 205 corresponding to the placement hole 203, the membrane hole sleeve 205 is plugged into the placement hole 203, and the inside of the membrane hole sleeve 205 is fixedly connected with a fan gasket 206, the fan gasket 206 is made of rubber material, the membrane hole sleeve 205 cooperates with the fan gasket 206 to achieve the sealing of the placement hole 203, effectively preventing external dust from entering the analyzer, and at the same time, when the reagent tube 3 is inserted into the placement hole 203, the fan gasket 206 tightens the reagent tube 3, effectively improving the placement stability of the reagent tube 3;

[0036] A row of test tube blocks 201 are installed on the sample tray 2, each test tube block 201 is fixed by a connecting piece 202, and then the outer film 204 covers the exposed test tube block 201, effectively closing the gap between the test tube block 201 and the sample tray 2 to prevent impurities from entering the analyzer. When the reagent tube 3 is inserted into the placement hole 203 on the test tube block 201, the reagent tube 3 squeezes and pushes open the fan gasket 206 in the membrane hole sleeve 205, and the fan gasket 206 is bent and folded to be laid between the reagent tube 3 and the inner wall of the placement hole 203. The elastic force of the fan gasket 206 is used for buffering, thereby effectively improving the placement stability of the reagent tube 3.

[0037] The second implementation method:

[0038] Compared with the first embodiment, the present embodiment mainly adds a fixed rail 5 and a latch plate 501. The specific newly added structures are as follows, and the remaining structures are consistent with the first embodiment.

[0039] Figure 1 and 10As shown, the inner ring of the test tube wheel 401 is fixedly inlaid with a magnetic block 403, and the magnetic block 403 is adsorbed and corresponds to the driving shaft 4. The magnetic block 403 is made of a magnet material. The magnetic block 403 is adsorbed with the driving shaft 4 to realize that the test tube wheel 401 is driven by the driving shaft 4 to rotate. The bottom of the box slot 101 is fixedly connected to a fixed rail 5, and the top of the fixed rail 5 is movably connected to a tooth plate 501. Both ends of the test tube wheel 401 are fixedly connected to a gear ring 502, and the tooth plate 501 is meshed with the gear ring 502. The gear ring 502 is meshed and locked to achieve the individual locking of the designated test tube wheel 401, so as to distinguish the working states of different test tube wheels 401. The upper surface of the fixed rail 5 is fixedly inlaid with an electromagnet sheet 503, and the lower surface of the latch plate 501 is fixedly inlaid with a magnet bar 504. The magnetic forces of the electromagnet sheet 503 and the magnet bar 504 repel each other. The electromagnet sheet 503 is energized to generate a magnetic force, which repels the magnet bar 504, so that the latch plate 501 rises, so that the latch plate 501 is meshed and locked with the gear ring 502.

[0040] When multiple reagent tubes 3 are simultaneously conducting sample analysis, and no new reagent has been added, and the reagent tubes 3 that do not need to be shaken are waiting for analysis, the experimenter selects the fixed rail 5 corresponding to the position of the reagent tube 3, and the electromagnet sheet 503 on the fixed rail 5 is energized to generate a magnetic force that repels the magnet bar 504, pushing the tooth plate 501 to rise, and the rising tooth plate 501 engages with the locking gear ring 502, thereby locking the test tube wheel 401 of the reagent tube 3, so that the reagent tube 3 no longer needs to be shaken and shaken, so that multiple reagent tubes 3 can perform different types of analysis operations at the same time, thereby effectively improving the sample analysis efficiency.

[0041] Figure 1 and Figure 10-11As shown, both ends of the bottom of the latch plate 501 are fixedly connected with a pad strip 6, and a socket 601 is provided on the surface of the pad strip 6. Both ends of the top of the fixed rail 5 are slidably connected with a movable bar 602. The bottom of the movable bar 602 is fixedly connected with a plug post 603, and the plug post 603 is plugged into and corresponds to the socket 601. When the latch plate 501 rises due to the repulsive force, the plug post 603 is inserted into the socket 601 to lock the latch plate 501 after rising, effectively improving the stability of the latch plate 501. The bottom of the fixed rail 5 is slidably connected with an electric slider 604, which is fixedly connected to the movable bar 602. 604 drives the movable bar 602 to move, thereby realizing the horizontal movement of the latch plate 501, and drives the gear ring 502 through meshing to realize the reverse rotation of the test tube wheel 401 alone. The top end of the fixed rail 5 away from the electric slider 604 is slidably connected with a top block 605, one end of the top block 605 is movably connected to the latch plate 501, and a return spring 606 is fixedly connected between the other end of the top block 605 and the inner wall of the box groove 101. The electric slider 604 drives the latch plate 501 to move in the direction of the top block 605, squeezing the return spring 606, and the latch plate 501 is subsequently restored to its position under the elastic force of the return spring 606;

[0042] When multiple reagent tubes 3 are simultaneously conducting sample analysis, and one of the reagent tubes 3 needs to be taken out separately, the experimenter first selects the corresponding reagent tube 3, repeats the previous operation of the electromagnet sheet 503 repulsing the tooth plate 501 to engage and lock the gear ring 502, and first locks the test tube wheel 401 of the reagent tube 3. During the locking process, the plug 603 at the bottom of the movable bar 602 is inserted into the socket 601 on the pad strip 6, and then the electric slider 604 drives the movable bar 602 to achieve horizontal displacement of the tooth plate 501, and drives the gear ring 502 in the reverse direction by engaging and driving. The test tube wheel 401 is pushed out in the reverse direction to facilitate the separate removal of the reagent tube 3, without affecting the analysis operation of other reagent tubes 3, and is convenient for different reagent tubes 3 to perform different analysis operations, thereby effectively improving the sample analysis efficiency.

[0043] In view of current practical needs, the above-mentioned implementation mode adopted in this application is not limited to the scope of protection. Various changes made within the knowledge scope of technical personnel in this field without departing from the concept of this application still fall within the scope of protection of the present invention.

Claims

1. An intelligent biological sample analyzer, characterized in that: The apparatus comprises an instrument body (1), one end of the instrument body (1) being fixedly connected to a box slot (101), the top of the box slot (101) being fixedly connected to a box cover (102), the middle of the box cover (102) being fixedly connected to a sample tray (2), and a reagent tube (3) being placed inside the sample tray (2); The inside of the box slot (101) is rotatably connected to a driving shaft (4), the outside of the driving shaft (4) is sleeved with a test tube wheel (401), the bottom of the reagent tube (3) contacts the outer surface of the test tube wheel (401), the outer surface of the test tube wheel (401) is fixedly connected to a top convex angle (402), the top convex angle (402) corresponds to the bottom of the reagent tube (3), the middle of the sample tray (2) is fixedly connected to a test tube block (201), and both ends of the test tube block (201) are fixedly connected to A connecting piece (202), the connecting piece (202) being fixedly connected to the inner wall of the sample tray (2), a placement hole (203) being provided in the middle of the test tube block (201), the reagent tube (3) being sleeved with the placement hole (203), the connecting piece (202) being bent in a U-shape, and the connecting piece (202) being made of an elastic plastic sheet, an outer coating (204) being provided on the outer surface of the sample tray (2), and an upper surface of the test tube block (201) being fixedly connected to the outer coating (204); The bottom of the box slot (101) is fixedly connected to a fixed rail (5), the top of the fixed rail (5) is movably connected to a tooth plate (501), both ends of the test tube wheel (401) are fixedly connected to a gear ring (502), the tooth plate (501) is meshed with the gear ring (502), the upper surface of the fixed rail (5) is fixedly inlaid with an electromagnet sheet (503), the lower surface of the tooth plate (501) is fixedly inlaid with a magnet bar (504), the magnetic forces of the electromagnet sheet (503) and the magnet bar (504) are repelling and corresponding, both ends of the bottom of the tooth plate (501) are fixedly connected to a pad strip (6), and a plug hole (601) is provided on the surface of the pad strip (6). The two ends of the top of the fixed rail (5) are slidably connected to movable bars (602), the bottom of the movable bar (602) is fixedly connected to a plug post (603), the plug post (603) is plugged into and corresponds to the socket (601), the bottom of the fixed rail (5) is slidably connected to an electric slider (604), the electric slider (604) is fixedly connected to the movable bar (602), the top of the fixed rail (5) is slidably connected to an end away from the electric slider (604), one end of the top block (605) is movably connected to the latch plate (501), and the other end of the top block (605) is fixedly connected to the inner wall of the box groove (101) with a return spring (606).

2. The intelligent biological sample analyzer according to claim 1, characterized in that: The top convex corner (402) is arranged in a fin shape, and both the arc surface and the flat surface of the top convex corner (402) correspond to the bottom of the test tube block (201).

3. The intelligent biological sample analyzer according to claim 1, characterized in that: A membrane hole sleeve (205) is fixedly connected to the placement hole (203) on the surface of the outer covering membrane (204); the membrane hole sleeve (205) is plugged into the placement hole (203); a fan gasket (206) is fixedly connected to the inside of the membrane hole sleeve (205); the fan gasket (206) is made of rubber material.

4. The intelligent biological sample analyzer according to claim 1, characterized in that: The inner ring of the test tube wheel (401) is fixedly inlaid with a magnetic attraction block (403), the magnetic attraction block (403) is adsorbed and corresponds to the driving shaft (4), and the magnetic attraction block (403) is made of a magnet material.

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