An antibacterial and soothing composition for children's eczema, and its preparation method and application

Abstract

The present invention relates to the field of cosmetic technology, and specifically discloses an antibacterial soothing composition that can be used for children's eczema, and a preparation method and application thereof. An antibacterial soothing composition that can be used for children's eczema includes 30-50 parts of marshmallow root complex, 10-20 parts of Spanish sage seed complex, 20-30 parts of salvia root complex, 20-30 parts of difficile root bark complex and 20-30 parts of sanguisorba officinalis complex. An application of an antibacterial soothing composition that can be used for children's eczema is to add the antibacterial soothing composition that can be used for children's eczema to cosmetics. The antibacterial soothing composition of the present application can promote the growth of beneficial bacteria on the skin and inhibit the growth of pathogenic bacteria through the survival competition of colonies, restore the balance of skin microecology, enhance skin barrier ability and effectively resist skin inflammation, soothe the discomfort of the skin, and bring a gentle and comfortable use experience to users, especially children.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an antibacterial and soothing composition that can be used for children's eczema, and a preparation method and application thereof. Background Art

[0002] There are thousands of bacteria living on the surface of human skin, the most important of which are beneficial saprophytic bacteria, which constitute the micro-ecological system of our skin. The dynamic balance of these micro-ecological systems is crucial to maintaining skin health and normal metabolism. When the micro-ecology is balanced, the beneficial bacteria coexist with the human body, interdependent, mutually beneficial, coordinated and restrained, forming the first protective barrier of our skin and maintaining skin health; however, once the micro-ecology is unbalanced, external pathogens may take advantage of the situation and cause eczema, dermatitis, acne, psoriasis and other problems.

[0003] Currently, the treatment of eczema is generally carried out by using fungicides or glucocorticoids with relatively strong bactericidal ability to kill the pathogenic bacteria that cause skin lesions, thereby alleviating the symptoms of eczema and relieving itching. Although this type of traditional treatment has the advantage of rapid results, it has the opposite effect. While killing pathogenic bacteria, traditional treatments will also kill beneficial bacteria that are beneficial to the skin, further damaging the already unbalanced skin microecology, leading to further damage to the skin's microbial barrier and making the skin more fragile and sensitive. Once treatment is stopped, eczema symptoms may recur or even become more serious.

[0004] Children's skin is very sensitive and fragile. This is because children's skin is 20%-30% thinner than adults' skin and is more easily damaged than adults. Children's skin is alkaline, while adults' is acidic. Bacteria are afraid of acidic skin, so infant skin is more susceptible to infection by pathogenic bacteria. Therefore, children are more likely to develop eczema and other diseases. However, traditional fungicides or glucocorticoids are too irritating for children, which may damage the skin barrier of children and cause repeated attacks of eczema, causing considerable troubles to children and their families. Therefore, it is particularly important to seek safer and more effective treatments for children's eczema. Summary of the invention

[0005] In order to treat pediatric eczema more safely and effectively, the present application provides an antibacterial soothing composition that can be used for pediatric eczema. The antibacterial soothing composition of the present application can promote the growth of beneficial bacteria on the skin and inhibit the growth of pathogenic bacteria through the survival competition of the colony, restore the balance of the skin microecology, enhance the skin barrier ability and effectively resist skin inflammation, soothe the discomfort of the skin, and bring a gentle and comfortable use experience to users, especially children.

[0006] In the first aspect, the present application provides an antibacterial and soothing composition that can be used for children's eczema, which adopts the following technical solution:

[0007] Disclosed is an antibacterial and soothing composition that can be used for children's eczema. The antibacterial and soothing composition that can be used for children's eczema comprises, by mass, 30-50 parts of marshmallow root complex, 10-20 parts of Spanish sage seed complex, 20-30 parts of salvia miltiorrhiza root complex, 20-30 parts of Dictamni root bark complex and 20-30 parts of Sanguisorba officinalis complex.

[0008] Preferably, the marshmallow root complex comprises 5%-10% marshmallow root extract, 45%-50% glycerol, and the remainder is water, based on the mass percentage of the marshmallow root complex.

[0009] Preferably, the Spanish chia seed complex comprises 96%-98% of Spanish chia seed extract and 2%-4% of lactobacillus fermentation product, based on the mass percentage of the Spanish chia seed complex.

[0010] Preferably, the salvia miltiorrhiza root complex comprises, by mass percentage, 3%-6% salvia miltiorrhiza root extract, 10%-20% butylene glycol, 0.1%-0.5% p-hydroxyacetophenone, and the balance is water.

[0011] Preferably, the Dictamni root bark complex comprises, by mass percentage, 3%-6% of the Dictamni root bark extract, 10%-20% of butylene glycol, 0.1%-0.5% of p-hydroxyacetophenone, and the remainder is water.

[0012] Preferably, the Sanguisorba officinalis complex comprises, by mass percentage, 3%-6% of Sanguisorba officinalis extract, 10%-20% of butylene glycol, 0.1%-0.5% of p-hydroxyacetophenone, and the balance is water.

[0013] In the above technical solution, the marshmallow root complex contains marshmallow root extract and glycerin. Among them, marshmallow is the root of marshmallow, a plant of the genus Althaea in the Malvaceae family. The marshmallow root extract is rich in polysaccharides, flavonoids, amino acids, glycoproteins and other active ingredients. It has multiple skin care effects such as deep moisturizing, repairing damaged skin and antibacterial and antioxidant effects. It can effectively soothe the skin and help wounds heal faster; and glycerin has good moisturizing properties, which can lock in skin moisture and prevent skin dryness. The combination of marshmallow root extract and glycerin, acting on the skin, can have a good soothing and moisturizing effect.

[0014] The Spanish chia seed complex contains Spanish chia seed extract and lactobacillus fermentation products. Among them, Spanish chia seed extract is rich in arabinogalactan, pectin and glucuronic acid xylan polymers, etc., which has an immunomodulatory effect and can promote cell division and promote the repair of the skin barrier. At the same time, Spanish chia seed extract has good anti-inflammatory and oil secretion inhibition effects, which can reduce skin inflammation and swelling problems, effectively reduce the production of skin oil, and improve skin condition. Lactobacillus fermentation products are a kind of beneficial bacteria metabolite that can promote the growth of beneficial bacteria and enhance the natural defense ability of the skin. The combination of Spanish chia seed extract and lactobacillus fermentation products has a good anti-inflammatory effect on the skin.

[0015] The salvia root complex contains salvia root extract, which is one of the common Chinese herbal medicines. It is generally used for promoting blood circulation, anti-inflammatory and analgesic purposes, and can improve human circulation and promote metabolism. Existing studies have shown that salvia root extract has good antioxidant effects, can well prevent the formation of pigmentation, and effectively remove oxygen free radicals in the skin, thereby achieving the effects of beauty and delaying skin aging. The butylene glycol in the salvia root complex is a moisturizer that can increase the moisture content of the skin and make the skin softer and smoother. Parahydroxyacetophenone is an antioxidant that can remove free radicals and delay skin aging. The combined use of salvia root extract, butylene glycol and parahydroxyacetophenone can further enhance the soothing and moisturizing effect of the antibacterial soothing composition and enhance its protective effect on the skin.

[0016] The Dictamni root bark complex contains Dictamni root bark extract. Dictamni is a perennial herb of the genus Dictamni of the Rutaceae family. The Dictamni bark extract is the root bark of the plant Dictamni, which is rich in various skin care ingredients, such as diffusine, trigonelline, choline, diffusin lactone, diffusin brain ester, sitosterol (whitening ingredient), berberine, berberine acid, fatty acids and crude saponins, etc. It has an inhibitory effect on melanocytes, and also has certain antibacterial, antiallergic and anti-inflammatory effects, and can effectively enhance the antibacterial and anti-inflammatory effects of the antibacterial and soothing composition.

[0017] The Sanguisorba officinalis complex contains Sanguisorba officinalis extract, which is a common traditional Chinese medicine used to treat skin damage, especially for the treatment of burns and scalds. The Sanguisorba officinalis extract is mainly extracted from the root of Sanguisorba officinalis, and has a strong ability to eliminate superoxide radicals and free radicals, and is an effective antioxidant. At the same time, studies have shown that the Sanguisorba officinalis extract has certain anti-inflammatory properties and can prevent skin addictive dermatitis. Adding it to the antibacterial soothing composition can further enhance the anti-inflammatory effect of the antibacterial soothing composition.

[0018] The present application forms a new antibacterial soothing composition by compounding a marshmallow root complex, a Spanish sage seed complex, a salvia root complex, a Dictamni root bark complex and a Sanguisorba officinalis complex. Such an antibacterial soothing composition not only combines the unique effects of the above-mentioned various components, but also achieves complementarity and enhancement among the components through synergistic effects, thereby achieving an unexpected effect of promoting the growth of beneficial bacteria on the skin. At the same time, the antibacterial soothing composition achieves the effect of significantly inhibiting the growth of pathogenic bacteria through the survival competition of beneficial bacterial colonies, thereby promoting the restoration of skin microecological balance, strengthening skin barrier function, fighting skin inflammation, relieving skin discomfort, and providing comprehensive care for skin with eczema.

[0019] In practical applications, the antibacterial soothing composition of the present application can be applied not only to skin with eczema, but also to healthy or sensitive skin to help maintain the healthy state of the skin. In addition, the components used in the antibacterial soothing composition of the present application are all mild and non-irritating plant extracts, which have good mild and non-irritating properties and are very suitable for adult sensitive skin and children's skin. It can help maintain and enhance the barrier function of the skin and nourish the skin in all directions, meeting the daily skin care needs of people with sensitive skin and children.

[0020] In a second aspect, the present application provides a method for preparing an antibacterial soothing composition that can be used for children's eczema, using the following technical solution:

[0021] A method for preparing an antibacterial and soothing composition that can be used for children's eczema comprises: mixing a formula amount of a marshmallow root complex, a Spanish sage seed complex, a salvia miltiorrhiza root complex, a Dictamni root bark complex and a Sanguisorba officinalis complex under room temperature conditions, stirring the mixture at a stirring speed of 15-30 r / min for 20-30 min, and then adjusting the pH to between 4.5 and 6.5 by a pH regulator to obtain the antibacterial and soothing composition that can be used for children's eczema.

[0022] In the above technical scheme, the present invention helps to maintain the activity of various ingredients in the antibacterial soothing composition by cleverly using mixing and stirring under normal temperature conditions and precise pH adjustment means, thereby effectively ensuring the stability and effectiveness of the antibacterial soothing composition and ensuring the user experience.

[0023] In a third aspect, the present application provides an antibacterial soothing composition that can be used for children's eczema using the following technical solution:

[0024] The invention discloses an application of an antibacterial and soothing composition that can be used for children's eczema, which comprises adding the antibacterial and soothing composition that can be used for children's eczema when preparing cosmetics.

[0025] In the above technical scheme, the antibacterial soothing composition of the present application can be added to various cosmetics, such as facial creams, skin care lotions, etc., to effectively relieve the symptoms of skin eczema, help restore the microecological balance of the skin, enhance the skin barrier capacity, and reduce the possibility of subsequent recurrence of eczema.

[0026] In summary, the present application includes at least one of the following beneficial technical effects:

[0027] 1. The antibacterial and soothing composition of the present application contains a marshmallow root complex, a Spanish sage seed complex, a salvia root complex, a Dictamni root bark complex and a Sanguisorba officinalis complex. Through such a unique formula combination, the present application produces a good synergistic effect between the components, thereby enhancing the antibacterial and anti-inflammatory, soothing and repairing effects, enhancing the skin's barrier function, and significantly inhibiting the further onset of eczema.

[0028] 2. The antibacterial soothing composition of the present application also maintains the pH value of the composition between 4.5 and 6.5 by adding a pH regulator, thereby further reducing the irritation of the composition to children's skin and improving the safety of use. DETAILED DESCRIPTION

[0029] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0030] Example 1

[0031] An antibacterial and soothing composition, the raw materials of which include a marshmallow root complex, a Spanish sage seed complex, a salvia miltiorrhiza root complex, a Dictamni root bark complex and a Sanguisorba officinalis complex.

[0032] Among them, marshmallow root complex contains the following ingredients: marshmallow root extract, glycerin and water.

[0033] The Spanish chia seed complex contains the following ingredients: Spanish chia seed extract and lactobacillus ferment.

[0034] Among them, Danshen root complex contains the following ingredients: Danshen root extract, butylene glycol, parahydroxyacetophenone and water.

[0035] Among them, the Dictamni root bark complex contains the following ingredients: Dictamni root bark extract, butylene glycol, p-hydroxyacetophenone and water.

[0036] Among them, the Sanguisorba officinalis complex contains the following ingredients: Sanguisorba officinalis extract, butylene glycol, p-hydroxyacetophenone and water.

[0037] Among them, marshmallow root extract was purchased from Guangzhou Youran Biotechnology Co., Ltd.

[0038] Among them, the Spanish chia seed extract was purchased from Guangzhou Noran Biotechnology Co., Ltd.

[0039] Among them, Salvia miltiorrhiza root extract was purchased from Quzhou Zhanhong Biotechnology Co., Ltd.

[0040] Among them, the Dictamni root bark extract was purchased from Quzhou Zhanhong Biotechnology Co., Ltd.

[0041] Among them, Sanguisorba officinalis extract was purchased from Quzhou Zhanhong Biotechnology Co., Ltd.

[0042] The amounts of each raw material and the ingredients contained in each raw material in the antibacterial soothing composition of Example 1 are shown in Table 1.

[0043] Table 1:

[0044]

[0045]

[0046] The preparation method of the antibacterial soothing composition of Example 1 comprises:

[0047] Under normal temperature conditions, the formulated amounts of marshmallow root complex, Spanish sage seed complex, salvia miltiorrhiza root complex, Dictamni root bark complex and Sanguisorba officinalis complex are mixed, then stirred at a stirring speed of 30 r / min for 2 minutes, and then the pH is adjusted to between 6.5 by a pH regulator to obtain an antibacterial and soothing composition that can be used for children's eczema.

[0048] Example 2

[0049] An antibacterial soothing composition, which is different from Example 1 in that the amounts of various raw materials used are inconsistent.

[0050] The amounts of each raw material and the ingredients contained in each raw material in the antibacterial soothing composition of Example 2 are shown in Table 2.

[0051] Table 2:

[0052]

[0053]

[0054] The preparation method of the antibacterial soothing composition of Example 2 comprises:

[0055] Under normal temperature conditions, the formulated amounts of marshmallow root complex, Spanish sage seed complex, salvia miltiorrhiza root complex, Dictamni root bark complex and Sanguisorba officinalis complex are mixed, then stirred at a stirring speed of 15 r / min for 30 minutes, and then the pH is adjusted to 4.5 by a pH regulator to obtain an antibacterial and soothing composition that can be used for children's eczema.

[0056] Example 3

[0057] An antibacterial soothing composition, which is different from Example 1 in that the amounts of various raw materials used are inconsistent.

[0058] The amounts of each raw material and the amounts of the components contained in each raw material in the antibacterial soothing composition of Example 3 are shown in Table 3.

[0059] Table 3:

[0060]

[0061]

[0062] The preparation method of the antibacterial soothing composition of Example 3 comprises:

[0063] Under normal temperature conditions, the formulated amounts of marshmallow root complex, Spanish sage seed complex, salvia miltiorrhiza root complex, Dictamni root bark complex and Sanguisorba officinalis complex are mixed, then stirred at a stirring speed of 25 r / min for 25 minutes, and then the pH is adjusted to 5.5 by a pH regulator to obtain an antibacterial and soothing composition that can be used for children's eczema.

[0064] Comparative Example 1

[0065] An antibacterial and soothing composition, which is different from Example 1 in that an equal amount of marshmallow root extract is replaced by gentian root extract.

[0066] Comparative Example 2

[0067] An antibacterial soothing composition, which is different from Example 1 in that an equal amount of Spanish sage seed extract is replaced by witch hazel extract.

[0068] Comparative Example 3

[0069] An antibacterial soothing composition, which is different from Example 1 in that an equal amount of Salvia miltiorrhiza root extract is replaced by Rhodiola rosea root extract.

[0070] Comparative Example 4

[0071] An antibacterial and soothing composition, which is different from Example 1 in that an equal amount of Dictamni root bark extract is replaced by Sophora flavescens root extract.

[0072] Comparative Example 5

[0073] An antibacterial soothing composition, which is different from Example 1 in that an equal amount of Sanguisorba officinalis extract is replaced by a Glycyrrhiza glabra root extract.

[0074] Application Example 1

[0075] An antibacterial and soothing moisturizer comprises 55.05 kg of water, 0.5 kg of glyceryl stearate, 2 kg of polyglyceryl-10 stearate, 2 kg of cetearyl alcohol, 10 kg of camellia oil, 5 kg of avocado oil, 2 kg of jojoba oil, 1 kg of tocopherol, 10 kg of glycerol, 3 kg of butylene glycol, 3 kg of trehalose, 0.15 kg of allantoin, 0.05 kg of disodium edetate, 0.3 kg of carbomer, 0.35 kg of arginine, 0.05 kg of caprylhydroxamic acid, 0.02 kg of ethylhexylglycerol, 0.53 kg of 1,2-hexanediol and 5 kg of an antibacterial and soothing composition.

[0076] Among them, the antibacterial soothing composition comes from Example 1.

[0077] The preparation method of the antibacterial soothing moisturizer comprises:

[0078] Step 1: Heat glyceryl stearate, polyglyceryl-10 stearate, cetearyl alcohol, camellia oil, avocado oil, jojoba oil, and tocopherol to 75°C and stir to dissolve evenly.

[0079] Step 2: Heat water, glycerin, butylene glycol, trehalose, allantoin, disodium EDTA and carbomer to 85°C and stir to dissolve evenly.

[0080] Step 3: Add the material obtained in step 1 to the material obtained in step 2, emulsify for 3 minutes, then homogenize for 10 minutes, and vacuum and cool.

[0081] Step 4: Cool down to below 45°C, add the remaining ingredients, stir well, and you will get the antibacterial and soothing moisturizer.

[0082] Application Example 2

[0083] An antibacterial soothing moisturizer, which is different from Application Example 1 in that the antibacterial soothing composition comes from Example 2.

[0084] Application Example 3

[0085] An antibacterial soothing moisturizer, which is different from Application Example 1 in that the antibacterial soothing composition is from Example 3.

[0086] Comparative application example 1

[0087] An antibacterial soothing moisturizer, which is different from Application Example 1 in that the antibacterial soothing composition comes from Comparative Example 1.

[0088] Comparative Application Example 2

[0089] An antibacterial soothing moisturizer, which is different from Application Example 1 in that the antibacterial soothing composition comes from Comparative Example 2.

[0090] Comparative Application Example 3

[0091] An antibacterial soothing moisturizer, which is different from Application Example 1 in that the antibacterial soothing composition comes from Comparative Example 3.

[0092] Comparative Application Example 4

[0093] An antibacterial soothing moisturizer, which is different from Application Example 1 in that the antibacterial soothing composition comes from Comparative Example 4.

[0094] Comparative Application Example 5

[0095] An antibacterial soothing moisturizer, which is different from Application Example 1 in that the antibacterial soothing composition comes from Comparative Example 5.

[0096] Comparative Example 1

[0097] A composition, which is different from Example 1 in that the marshmallow root extract, the Spanish sage seed extract, the salvia miltiorrhiza root extract, the Dictamni root bark extract and the Sanguisorbae officinalis extract are replaced with water in equal amounts.

[0098] Comparative Example 2

[0099] A moisturizing cream, which is different from Application Example 1 in that the antibacterial soothing composition is replaced by the composition of Control Example 1 in equal amounts.

[0100] 1. The potential adverse reactions of the antibacterial and soothing composition of the present application were detected by the skin occlusive patch test according to the 2015 edition of the "Technical Specification for Safety of Cosmetics".

[0101] The antibacterial soothing compositions of the above-mentioned embodiments and comparative examples were respectively placed in the small chamber of the spot tester, with an amount of about 0.025 mL. The spot tester with the test substance added was applied to the back of the subject with 3M tape, and the palm of the hand was gently pressed to make it evenly applied to the skin for 24 hours. The skin reaction was observed according to the criteria of Table 4 at 30 minutes (after the indentation disappears), 24 hours and 48 hours after the removal of the test substance spot tester, and the observation results were recorded.

[0102] Table 4:

[0103]

[0104] The test results show that the antibacterial soothing compositions of the above-mentioned embodiments and comparative examples all have negative reactions, are mild and non-irritating, and have no potential adverse reactions to the skin.

[0105] 2. Verify that the antibacterial soothing composition can selectively promote the growth of beneficial bacteria, and verify that the antibacterial soothing composition can inhibit the growth of pathogenic bacteria through survival competition of colonies.

[0106] Verification 1: The experimental group selected the moisturizers of the above-mentioned application examples and comparative application examples as the base culture medium, and the control group selected the moisturizer of comparative example 2 as the base culture medium, and cultivated beneficial bacteria and pathogenic bacteria in the above culture medium respectively for 48 hours, and then detected the amount of the remaining base, wherein the base consumption is 0-20%, recorded as (-), the consumption is 20%-40%, recorded as (+); the consumption is 40%-60%, recorded as (++); the consumption is 60%-100%, recorded as (+++). The experimental results are shown in Table 5.

[0107] Verification 2: Lactobacillus pentosus and Staphylococcus aureus were inoculated simultaneously in the culture medium of the experimental group (same as Verification 1) and the control group (same as Verification 1), and the colony data of beneficial bacteria and Staphylococcus aureus were counted at 0h, 6h, 24h and 48h, and the approximate number of colonies was calculated. The experimental results are shown in Table 6.

[0108] Table 5:

[0109]

[0110] Table 6:

[0111]

[0112]

[0113] Combined with the analysis of the above Application Examples 1-3, Comparative Application Examples 1-5, Control Example 2 and Tables 5-6, Application Examples 1-3 can selectively promote the growth of beneficial bacteria and inhibit the growth of pathogenic bacteria through survival competition of colonies.

[0114] The moisturizers of Application Examples 1-3 and Comparative Application Examples 1-5 were added with the antibacterial soothing compositions of Examples 1-3 and Comparative Examples 1-5, respectively, while the antibacterial soothing compositions were not added to the moisturizer of Comparative Example 2. From Table 5, we can clearly see that the consumption of beneficial bacteria, such as Micrococcus kluyveri and Lactobacillus pentosus, in Application Examples 1-3 is greater, which indicates that only the antibacterial soothing compositions with the addition of Marshmallow Root Complex, Salvia Hispanica Seed Complex, Salvia Miltiorrhiza Root Complex, Dictamni Root Bark Complex and Sanguisorba Officinalis Complex can significantly promote the growth of beneficial bacteria, which helps to maintain the balance of skin microecology and improve the natural defense ability of the skin.

[0115] Further observing Table 6, we can see that in Application Examples 1-3, the number of beneficial bacteria, namely Lactobacillus pentosus, increased significantly over time, while the number of pathogenic bacteria, namely Staphylococcus aureus, decreased significantly. This shows that the antibacterial soothing composition not only promotes the growth of beneficial bacteria, but also inhibits the growth of pathogenic bacteria through the survival competition of the colony, which further proves the antibacterial and soothing effects of the antibacterial soothing composition of the present application.

[0116] 3. To verify the soothing and anti-inflammatory effects of the antibacterial soothing composition.

[0117] After a week of adaptive feeding of several healthy guinea pigs, guinea pigs suitable for the experiment were selected and divided into 10 groups, each with 10. The dorsum of the right lower limb of each group of guinea pigs was shaved, and the corresponding sample was applied to the right lower limb of the guinea pig at 0.1 mL / pig. The samples of the experimental group were the antibacterial and soothing compositions of the above embodiments and comparative examples, the sample of the negative control group was the composition of Control Example 1, and the sample of the positive control group was Piyanping cream, which was applied for two consecutive days.

[0118] On the third day, the hair-free area on the dorsum of the right lower limb was scratched with coarse sandpaper, with an area of ​​1cm 2 , and then apply the corresponding sample locally. After waiting for 1 hour, histamine solution (which can cause allergic symptoms such as redness, swelling and itching of the skin) was dripped on the wound surface, with a dripping amount of 0.05 mL / guinea pig, and the concentration was increased by 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.2%, and 0.3% every 3 minutes until the guinea pigs became restless and turned back to lick their hind feet. The concentration of histamine solution used when the guinea pigs in each group began to become restless and turn back to lick their hind feet was recorded, and the results were averaged, as shown in Table 7.

[0119] Table 7:

[0120] Group The concentration of histamine solution used when the guinea pig began to become restless and lick its hind paws Negative control group 0.01％ Positive control group 0.1％ Example 1 0.21％ Example 2 0.2％ Example 3 0.24％ Comparative Example 1 0.075％ Comparative Example 2 0.054％ Comparative Example 3 0.082％ Comparative Example 4 0.066％ Comparative Example 5 0.071％

[0121] Combining Examples 1-3, Comparative Examples 1-5 and Table 7, it can be seen that the antibacterial soothing compositions of Examples 1-3 of the present application have good soothing and anti-inflammatory effects.

[0122] Specifically combined with Example 1 and Comparative Examples 1-5, the antibacterial soothing composition of Example 1, compared with Comparative Examples 1-5, uses a special combination of marshmallow root complex, Spanish sage seed complex, salvia root complex, Dictamni root bark complex and Sanguisorba officinalis complex, and shows good tolerance in the allergic skin test of guinea pigs, which shows that the specific formula and composition of the antibacterial soothing composition have a significant impact on its soothing and anti-inflammatory effects. Therefore, the applicant analyzed and believed that the combination of marshmallow root complex, Spanish sage seed complex, salvia root complex, Dictamni root bark complex and Sanguisorba officinalis complex is the key to significantly improve the tolerance of guinea pigs, and such an antibacterial soothing composition has a better soothing and anti-inflammatory effect.

[0123] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. An antibacterial and soothing composition that can be used for children's eczema, characterized in that: The antibacterial and soothing composition for children's eczema comprises, by weight, 30-50 parts of marshmallow root complex, 10-20 parts of sage seed complex, 20-30 parts of salvia root complex, 20-30 parts of difficile root bark complex and 20-30 parts of sanguisorba officinalis complex; Calculated by mass percentage of the marshmallow root complex, the marshmallow root complex comprises 5%-10% marshmallow root extract, 45%-50% glycerol, and the balance is water; The Spanish chia seed complex comprises, by mass percentage of the Spanish chia seed complex, 96%-98% of Spanish chia seed extract and 2%-4% of lactobacillus fermentation product; Calculated by mass percentage of the salvia miltiorrhiza root complex, the salvia miltiorrhiza root complex comprises 3%-6% of salvia miltiorrhiza root extract, 10%-20% of butylene glycol, 0.1%-0.5% of p-hydroxyacetophenone, and the balance is water; Calculated by mass percentage of the Dictamni root bark complex, the Dictamni root bark complex comprises 3%-6% of the Dictamni root bark extract, 10%-20% of butylene glycol, 0.1%-0.5% of p-hydroxyacetophenone, and the balance is water; Calculated by mass percentage, the Sanguisorba officinalis complex comprises 3%-6% of Sanguisorba officinalis extract, 10%-20% of butylene glycol, 0.1%-0.5% of p-hydroxyacetophenone, and the balance is water.

2. A method for preparing the antibacterial soothing composition for children's eczema as claimed in claim 1, characterized in that: Under normal temperature conditions, the formula amounts of marshmallow root complex, Spanish sage seed complex, salvia miltiorrhiza root complex, Dictamni root bark complex and Sanguisorba officinalis complex are mixed, and then stirred at a stirring speed of 15-30 r / min for 20-30 min, and then the pH is adjusted to between 4.5 and 6.5 by a pH regulator to obtain an antibacterial and soothing composition that can be used for children's eczema.

3. An application of the antibacterial soothing composition for children's eczema as claimed in claim 1, characterized in that: The antibacterial and soothing composition which can be used for children's eczema is added when preparing cosmetics.

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