A feed additive for improving reproductive performance of ewes and its application

Abstract

The present invention is applicable to the technical field of feed additives, and provides a feed additive and application thereof for improving the reproductive performance of ewes, wherein the feed additive includes D-aspartic acid and N-carbamylglutamate, and the masses of D-aspartic acid and N-carbamylglutamate are 0.5 grams and 1.5 grams, respectively. The present invention innovatively combines D-aspartic acid with N-carbamylglutamate for ewe breeding, which can significantly improve the fertility of ewes and is suitable for promotion in farms. The feed additive can effectively improve the number of superovulations, high-quality egg rate, estrus rate, pregnancy rate, and number of lambs of ewes, while improving the health of lambs. Compared with reproductive hormones, functional amino acids have low cost, simple operation, no increase in labor burden, and overcome the problem of side effects such as abnormal ovarian development caused by long-term use of reproductive hormones to improve the fertility of ewes, ensuring the green, healthy and sustainable nature of the breeding process, and laying a solid foundation for the long-term development of the breeding industry.

Description

Technical Field

[0001] The invention belongs to the technical field of feed additives, and in particular relates to a feed additive for improving the reproductive performance of ewes and an application thereof. Background Art

[0002] The low reproductive capacity of ewes has become a bottleneck restricting the efficient development of the mutton industry. Among them, the lack of estrus and long interval between estrus after calving are one of the main factors causing the low reproductive capacity of ewes. At present, the technology to improve the reproductive capacity of ewes usually uses exogenous hormones to induce estrus (synchronous estrus) and shorten the interval between estrus after calving, which plays a positive role in improving the reproductive capacity of ewes. However, the exogenous hormone treatment method has its limitations. On the one hand, the mechanism of the long period of lack of estrus after calving in ewes is unclear. The current method does not consider the development of the intrinsic hypothalamus-pituitary-ovary status of ewes, which is somewhat blind. In addition, repeated use of exogenous hormones or improper use will cause side effects such as ovarian cysts, estrus and abnormal ovulation in ewes. Therefore, from the perspective of sustainable development, the hormone treatment method has obvious shortcomings. Therefore, it is urgent to develop green, safe, efficient and sustainable technologies to shorten the interval between estrus after calving in ewes.

[0003] In addition, the survival rate of lambs can be improved by adjusting the breeding time (breeding from August to September to October to November) and the lambing time to spring (March 10 to April 15). Artificial insemination technology can also be used to improve conception rate and reproductive efficiency. In the application of functional amino acids, there have been some preliminary studies in China on the effects of functional amino acids (such as NCG and D-aspartic acid) on the reproductive performance, growth rate and meat quality of single-born animals. However, due to the complex rumen structure of ruminants such as sheep, it is not clear whether functional amino acids can be applied to sheep to improve their production or reproductive efficiency. For this reason, a feed additive for improving the reproductive performance of ewes and its application are proposed. Summary of the invention

[0004] The object of the present invention is to provide a feed additive for improving the reproductive performance of ewes and its application, aiming to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A feed additive for improving the reproductive performance of ewes. The feed additive comprises D-aspartic acid and N-carbamylglutamate, wherein the masses of the D-aspartic acid and the N-carbamylglutamate are 0.5 grams and 1.5 grams respectively.

[0007] An application of the feed additive described above in preparing feed for improving the reproductive performance of ewes.

[0008] A ewe feed, comprising the feed additive as described above.

[0009] Furthermore, the feed also includes a basic diet, and the basic diet includes the following raw materials in percentage by mass:

[0010] Corn 40%, soybean meal 8%, rapeseed meal 10%, soybean hulls 10%, corn DDGS 20%, rice bran meal 6%, cane molasses 2%, expanded urea 200 type 0.7%, stone powder 1.6%, sodium chloride 0.8%, sodium sulfate 0.2% and Hefeng premix 0.7%.

[0011] Compared with the prior art, the present invention has the following beneficial effects:

[0012] 1. The present invention is the first to apply a combination of D-aspartic acid and N-carbamylglutamate to ewe breeding, which can significantly improve the reproductive capacity of ewes and can be promoted and applied in breeding farms.

[0013] 2. The feed additive proposed by the present invention can increase the number of superovulation, high-quality egg rate, estrus rate, pregnancy rate, and number of lambs of ewes, and improve the health of lambs.

[0014] 3. Compared with the application of traditional reproductive hormones, the present invention shows significant advantages. The use cost of functional amino acids is lower and does not increase the extra labor burden of the farm. More importantly, the present invention overcomes the problem of side effects such as abnormal ovarian development caused by long-term use of reproductive hormones to improve the fertility of ewes, ensures the green, healthy and sustainable breeding process, and lays a solid foundation for the long-term development of the breeding industry.

[0015] 4. The implementation method of the present invention is simple to operate. It only requires adding the feed additive to the daily feed during the key breeding stage of the ewes, without the need for complex technical support or equipment investment. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Schematic diagram of the experimental scheme of the present invention. DETAILED DESCRIPTION

[0017] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0018] The specific implementation of the present invention is described in detail below in conjunction with specific embodiments.

[0019] To explore the effects of different levels of D-aspartic acid and N-carbamylglutamate on reproductive indicators of ewes ( Figure 1), we added different levels of D-aspartic acid and N-carbamoylglutamate to the basal diet of ewes (Table 1). Specifically, the experiment designed six different groups, including a control group and five experimental groups (experimental groups 1 to 5), and the basal diet of each sheep in each group was 4 kilograms per day. The control group only provided a basal diet without additional additives, and experimental groups 1 to 5 added different proportions of D-aspartic acid and N-carbamoylglutamate. These groups are shown in Table 2:

[0020] Table 1. Basic feed formula for ewes

[0021] ;

[0022] Table 2. Feeding amount of D-aspartic acid and N-carbamylglutamate

[0023] .

[0024] Example 1: 90 Liaoning cashmere goat ewes before puberty were divided into 6 groups, each with 15 goats, and fed with different combinations of D-aspartic acid and N-carbamylglutamate for 45 days according to the experimental scheme in Table 2. After the experiment, superovulation was performed on the ewes, and the number of ovulations and the rate of high-quality eggs were observed and recorded. The results are shown in Table 3:

[0025] Table 3. Effects of amino acid combinations on the quality and quantity of ewes' eggs

[0026] ;

[0027] From the perspective of comprehensive feeding effects and feeding costs, it can be seen from the results in Table 3 that after feeding the functional amino acid combination, compared with the control group, the experimental group 4 had the best effect. The functional amino acid combination was D-aspartic acid (0.5 g) + N-carbamylglutamate (1.5 g). The average number of superovulated eggs per sheep increased by 1.6 (p<0.05), and the rate of high-quality eggs increased by 12.3% (p<0.05).

[0028] Example 2: 84 Liaoning cashmere goat ewes before mating were divided into 6 groups, each with 14 goats, and fed with different combinations of D-aspartic acid and N-carbamylglutamate according to the experimental scheme in Table 2 for 45 days. After the experiment, the estrus rate, pregnancy rate and number of lambs were observed and recorded. The results are shown in Table 4:

[0029] Table 4. Effects of amino acid combinations on estrus, pregnancy and lambing in ewes

[0030] ;

[0031] From the results in Table 4, it can be found that after feeding the functional amino acid combination, both experimental group 4 and experimental group 5 achieved significant results. However, considering the feeding cost, compared with the control group, experimental group 4 had the best effect in terms of comprehensive effect and feeding cost. The functional amino acid combination was D-aspartic acid (0.5 g) + N-carbamylglutamate (1.5 g), and the natural estrus rate of ewes increased significantly by 15.2% (p<0.05), the pregnancy rate increased by 7.2% (p<0.05), and the number of lambs increased by 11.3% (p<0.05).

[0032] Example 3: 120 pregnant Liaoning cashmere goat ewes before lambing were divided into 6 groups, each with 20 goats, and fed with different combinations of D-aspartic acid and N-carbamylglutamate according to the experimental scheme in Table 2 for 45 days until lambing. After the experiment, the health indicators of the lambs such as birth weight, weaning survival rate, and diarrhea rate were observed and recorded. The results are shown in Table 5:

[0033] Table 5. Effects of amino acid combinations on lamb health

[0034] ;

[0035] From the results in Table 5, it can be found that after feeding the functional amino acid combination, experimental groups 3, 4 and 5 all achieved significant results. However, considering the comprehensive feeding effect and feeding cost, compared with the control group, experimental group 4 had the best effect in terms of both comprehensive effect and feeding cost. The functional amino acid combination was D-aspartic acid (0.5 g) + N-carbamylglutamate (1.5 g). The average birth weight of lambs increased by 0.08 kg (p<0.05), the weaning survival rate increased by 4.2% (p<0.05), and the diarrhea rate decreased by 9.5% (p<0.05).

[0036] in conclusion:

[0037] 1. The present invention is the first to apply a combination of D-aspartic acid and N-carbamylglutamate to ewe breeding, which can significantly improve the reproductive capacity of ewes and can be promoted and applied in breeding farms.

[0038] 2. The feed additive proposed by the present invention can increase the number of superovulation, high-quality egg rate, estrus rate, pregnancy rate, and number of lambs of ewes, and improve the health of lambs.

[0039] 3. Compared with the application of traditional reproductive hormones, the present invention shows significant advantages. The use cost of functional amino acids is lower and does not increase the extra labor burden of the farm. More importantly, the present invention overcomes the problem of side effects such as abnormal ovarian development caused by long-term use of reproductive hormones to improve the fertility of ewes, ensures the green, healthy and sustainable breeding process, and lays a solid foundation for the long-term development of the breeding industry.

[0040] 4. The implementation method of the present invention is simple to operate. It only requires adding the feed additive to the daily feed during the key breeding stage of the ewes, without the need for complex technical support or equipment investment.

[0041] The above are only preferred embodiments of the present invention. It should be pointed out that, for those skilled in the art, several modifications and improvements can be made without departing from the concept of the present invention. These should also be regarded as the protection scope of the present invention. These will not affect the effect of the implementation of the present invention and the practicality of the patent.

Claims

1. A feed additive for improving the reproductive performance of ewes, characterized in that: The feed additive comprises D-aspartic acid and N-carbamylglutamate, and the masses of D-aspartic acid and N-carbamylglutamate are 0.5 grams and 1.5 grams respectively.

2. Use of the feed additive according to claim 1 in preparing feed for improving the reproductive performance of ewes.

3. A ewe feed, characterized in that: The feed comprises the feed additive according to claim 1.

4. The feed according to claim 3, characterized in that The feed also includes a basic diet, which includes the following raw materials in percentage by mass: Corn 40%, soybean meal 8%, rapeseed meal 10%, soybean hulls 10%, corn DDGS 20%, rice bran meal 6%, cane molasses 2%, expanded urea 200 type 0.7%, stone powder 1.6%, sodium chloride 0.8%, sodium sulfate 0.2% and Hefeng premix 0.7%.

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