Composition with skin barrier repairing effect as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and discloses a composition with a skin barrier repairing effect and a preparation method and application thereof. The composition disclosed by the invention is prepared from the following components: PEG-75 shea butter glyceride, phytosterol / octyldodecanol lauroyl glutamate, glycosylglycerol, panthenol and glyceryl oleate. According to the composition, through the synergistic interaction of PEG-75 shea butter glyceride, phytosterol / octyldodecanol lauroyl glutamate, glycosylglycerol, panthenol and glyceryl oleate, the irritation of a surfactant can be reduced, lipid components required by a skin barrier can be supplemented, lipid lost in damaged skin can be filled up, TEWL can be inhibited, and the skin care effect can be improved. The traditional Chinese medicine composition is capable of increasing the moisture content of cuticle, relieving inflammation, relieving symptoms such as red and swollen skin and pruritus, creating a good internal environment for barrier repair, improving the repair capacity of the skin, improving the skin state and repairing the skin barrier.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a composition with skin barrier repairing effect, a preparation method and application thereof. Background Art

[0002] With the improvement of people's living standards and the pursuit of beauty, skin care has become an indispensable part of daily life. However, due to environmental pressure, bad living habits, excessive skin care and other factors, more and more people's skin barriers are damaged. Damage to the skin barrier will lead to faster water loss, susceptibility to external stimuli, inflammatory reactions and other problems, which seriously affect the health and beauty of the skin. In the field of skin care, cleansing products are the first and most important step in the daily skin care routine. Traditional cleansing products tend to focus on cleaning power, but ignore the protection and repair of the skin barrier. Some strong cleansing products may excessively remove surface oil and keratin, destroy the skin's natural barrier, and cause the skin to become dry and sensitive.

[0003] At present, facial cleansing products on the market are mainly aimed at cleaning, and most products are single or can only achieve short-term immediate effects. There are relatively few skin care products that aim to improve the overall condition of the skin or even repair the skin barrier, and some of them are either ineffective or highly irritating.

[0004] Therefore, developing a product that can repair damaged skin barrier has become an important research direction in the industry. Summary of the invention

[0005] The present invention aims to solve at least one of the technical problems existing in the above-mentioned prior art. To this end, the present invention provides a composition with skin barrier repairing effect and its preparation method and application, which can reduce the irritation of surfactants, strengthen the skin lipid layer, play a role in skin barrier repair, and is suitable for various cleansing products.

[0006] The first aspect of the present invention provides a composition, comprising the following components: PEG-75 shea butter glycerides, phytosteryl / octyldodecanol lauroyl glutamate, glyceryl glucoside, panthenol and glyceryl oleate.

[0007] Specifically, PEG-75 shea butter glycerides can effectively reduce the irritation of surfactants in cleansing product formulas, making them softer; improve softness, improve the stability of the foam structure and the milky texture, increase viscosity, and reduce irritation to sensitive skin. The molecular structure of PEG-75 shea butter glycerides contains hydrophilic and lipophilic parts; the hydrophilic part can attract and bind water molecules, while the lipophilic part can blend with the oil on the surface of the skin. This property enables it to lock moisture on the surface of the skin and reduce the evaporation of moisture, thereby achieving a moisturizing effect. PEG-75 shea butter glycerides can fill the gaps between skin cells, making the skin surface smoother; at the same time, it can increase the elasticity and flexibility of the skin, making the skin feel softer and smoother; it can also help replenish the lipid components needed for the skin barrier, repair the damaged stratum corneum structure, and improve the integrity of the skin barrier by strengthening the connection between keratinocytes, reducing the invasion of external irritants.

[0008] Specifically, phytosterol / octyldodecanol lauroyl glutamate is a fully plant-based amino acid derivative (amide ester). It has the same structure as ceramide, has high moisturizing properties and a plate-like liquid crystal structure, and can exert the same effect as ceramide. The barrier function of the skin will be affected by the intercellular lipids in the stratum corneum. Ceramides account for about 50% of the intercellular lipids and are an important component in maintaining the barrier function of the skin. They can inhibit TEWL (transepidermal water evaporation), increase the amount of moisture in the stratum corneum, and interact with lipids on the surface of the skin to form a moisturizing film. This film can prevent the loss of moisture inside the skin, while absorbing a certain amount of moisture from the environment to provide continuous moisture to the skin. It can replenish the lipid components required for the skin barrier, such as cholesterol, fatty acids, etc. These lipids help to restore the tight connection between stratum corneum cells and enhance the structural integrity of the skin barrier. Phytosterols themselves have certain antioxidant activity, which can neutralize free radicals and reduce the oxidative damage of free radicals to skin cells. Its chemical structure is relatively mild and is not easy to cause allergic reactions or irritation to the skin. At the same time, it has good compatibility with the skin and can exert its effects without destroying the normal physiological balance of the skin. By increasing the moisture content of the skin and improving the lipid balance, it makes the skin cells fuller and more elastic, making the skin surface smoother and softer.

[0009] Specifically, the keratinocyte layer of the skin contains a large amount of aquaporin AQP3, which regulates the absorption and transportation of water in cells, but is easily damaged by age, environmental and other stresses. Glyceryl glucoside can enhance the expression of aquaporin in epidermal cells, fundamentally enhancing the ability of cells to actively absorb water. In addition, the molecular size of glyceryl glucoside is only 1 / 3 of hyaluronic acid, which is easily absorbed by cells and can significantly increase the transcription of mRNA (messenger RNA) encoding AQP3 in cells, thereby allowing cells to synthesize a large amount of AQP3, restore the normal level of water channels on the cell membrane, maintain skin hydration, prevent water loss, achieve physiological moisturizing, and continuously lock moisture from the inside out for the skin, providing long-term moisturizing. Glyceryl glucoside can improve the skin barrier function and promote the regeneration of NMF filaggrin. In the upper epidermal stratum corneum, filaggrin is further processed into amino acids to help the skin retain moisture. It is an essential protein in the formation of the skin barrier. Glyceryl glucoside can inhibit inflammation by inhibiting the expression of inflammatory cytokines IL-1β and IL-1α, inhibiting mast cell degranulation, reducing the release of inflammatory factors, refreshing and reducing redness, soothing and nourishing, strengthening the skin barrier, and solving skin inflammation problems from the root. Glyceryl glucoside can also promote the production of the antioxidant skin protection enzyme "superoxide dismutase 1" (SOD1), strengthen the skin's own immune system, and activate the cell's antioxidant capacity. Collagenase is an enzyme that can cut the structure of collagen. It will be produced in large quantities when the skin is inflamed. Controlling its activity and removal is particularly important for anti-aging. Glyceryl glucoside can accurately locate, deeply repair, effectively promote collagen and elastin synthesis, strengthen the skin base, smooth fine lines, hard core against early aging, and make the skin elastic and firm. It helps inhibit the production of cellular melanin, cleans up the black layer by layer, evens out the skin tone, and makes the skin bright and translucent from the inside out.

[0010] Specifically, after panthenol is absorbed by skin tissue, the alcohol hydroxyl group is oxidized and converted into pantothenic acid, which is the most important raw material for synthesizing coenzyme A. Coenzyme A is an important substance for metabolism in the body (such as tricarboxylic acid cycle, lipid metabolism, etc.). Therefore, after panthenol is converted into pantothenic acid, it can promote the metabolism of human proteins, lipids, and carbohydrates, as well as protect the skin and mucous membranes. Panthenol has a small molecular weight and can effectively penetrate the stratum corneum and infiltrate the stratum corneum on the surface of the skin. It has a strong moisturizing effect, effectively improves skin roughness, makes the skin soft, and is not sticky. Panthenol can stimulate epithelial cell growth, accelerate epidermal wound healing time, and repair tissue trauma; it can inhibit the release of inflammatory factors, thereby reducing inflammatory reactions and soothing skin sensitivity. Experimental studies have shown that after using capsaicin to stimulate keratinocytes, the release of inflammatory factors IL-6 and IL-8 increased significantly. After using panthenol, the release of inflammatory factors IL-6 and IL-8 was effectively inhibited, indicating that panthenol can inhibit the release of inflammatory factors.

[0011] Specifically, glyceryl oleate is an important component of human skin and a barrier of the lipid layer in the skin. It has the effects of moisturizing, strengthening the lipid layer, and making the skin smooth.

[0012] The composition of the present invention is added to the product, and the irritation of the surfactant in the product can be reduced through PEG-75 shea butter glycerides;

[0013] Panthenol relieves skin inflammation, repairs the stratum corneum, replenishes moisturizing factors, enables the skin to re-establish its proper protective layer, and prevents skin degreasing and loss of moisturizing lipids;

[0014] Phytosterol / octyldodecanol lauroyl glutamate inhibits TEWL (transepidermal water evaporation), increases the moisture content of the stratum corneum, and can interact with lipids on the skin surface to form a moisturizing film;

[0015] Glyceryl glucoside can enhance the expression of aquaporins in epidermal cells, fundamentally enhancing the ability of cells to actively absorb water, preventing the loss of water inside the skin, while absorbing a certain amount of water from the environment to provide continuous moisture for the skin, and can also coordinate and assist in soothing skin inflammation;

[0016] Glyceryl oleate is an important component of the skin and a barrier to the lipid layer in the skin. It has the effect of moisturizing and making the skin smooth. It has excellent skin-friendly ability and can reshape the skin lipid barrier, forming a smooth lipid film on the skin surface, reducing transepidermal water loss. It can also penetrate into the stratum corneum of the skin to enhance skin elasticity and achieve a moisturizing effect. In the surfactant system, it has excellent resistance to washing, can relieve the tightness after washing with detergent products, and give the skin a smooth feeling.

[0017] The composition of the present invention is compounded with PEG-75 shea butter glycerides, phytosterol / octyldodecanol lauroyl glutamate, glyceryl glucoside, panthenol and glyceryl oleate to exert a synergistic effect, can reduce the stimulation of surfactants, replenish the lipid components required for the skin barrier, can fill the missing lipids in damaged skin, inhibit TEWL, increase the moisture content of the stratum corneum, reduce inflammation, relieve skin symptoms such as redness, swelling and itching, create a good internal environment for barrier repair, enhance the skin's own repair ability, and improve the skin condition.

[0018] In some embodiments of the present invention, the composition comprises the following components, measured by weight: 5-20 parts of PEG-75 shea butter glycerides, 20-40 parts of phytosterol / octyldodecanol lauroyl glutamate, 5-20 parts of glyceryl glucoside, 20-40 parts of panthenol and 5-20 parts of glyceryl oleate.

[0019] In some embodiments of the present invention, the composition comprises the following components, measured by weight: 10-20 parts of PEG-75 shea butter glycerides, 30-40 parts of phytosterol / octyldodecanol lauroyl glutamate, 10-20 parts of glyceryl glucoside, 30-40 parts of panthenol and 10-20 parts of glyceryl oleate.

[0020] The second aspect of the present invention provides a method for preparing the composition according to the first aspect of the present invention, comprising the following steps:

[0021] The components are mixed to obtain a composition.

[0022] The third aspect of the present invention provides use of the composition described in the first aspect of the present invention in preparing a product for skin barrier repair.

[0023] The fourth aspect of the present invention provides a facial cleansing product, comprising the composition described in the first aspect of the present invention.

[0024] In some embodiments of the present invention, the content of the composition is 0.01-50 wt %.

[0025] In some embodiments of the present invention, the content of the composition is 5-50 wt %.

[0026] In some embodiments of the present invention, the facial cleansing product further comprises at least one of a surfactant, a thickener, a pH adjuster, a preservative, and a chelating agent.

[0027] In some embodiments of the present invention, the facial cleansing product includes any one of a facial cleanser, a facial cleansing milk, a facial cleansing cream or a facial cleansing mousse.

[0028] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0029] (1) The composition provided by the present invention can reduce the irritation of surfactants, replenish the lipid components required for the skin barrier, fill the missing lipids in damaged skin, inhibit TEWL, increase the moisture content of the stratum corneum, reduce inflammation, relieve symptoms such as redness, swelling, and itching of the skin, create a good internal environment for barrier repair, improve the skin's own repair ability, improve the skin condition, and repair the skin barrier through the synergistic enhancement of PEG-75 shea butter glycerides, phytosterol / octyldodecanol lauroyl glutamate, glyceryl glucoside, panthenol, and glyceryl oleate.

[0030] (2) The composition provided by the present invention improves and repairs skin problems from different aspects, and is mild and non-irritating. In addition, the optimal effect is further achieved through a specific ratio, and has excellent skin barrier repair effect, and is mild and non-irritating, solving the problem of high irritation of traditional cleansing products, and thus has a relatively broad application prospect. DETAILED DESCRIPTION

[0031] In order to make the technical scheme of the present invention more clearly understood by those skilled in the art, the following embodiments are listed for illustration. It should be pointed out that the following embodiments do not limit the protection scope of the present invention.

[0032] Unless otherwise specified, the raw materials, reagents or devices used in the present invention can be obtained from conventional commercial channels or by existing known methods.

[0033] Example 1

[0034] A composition comprises the following components in parts by weight: 10 parts of PEG-75 shea butter glycerides, 30 parts of phytosterol / octyldodecanol lauroyl glutamate, 20 parts of glyceryl glucoside, 30 parts of panthenol and 10 parts of glyceryl oleate.

[0035] The preparation method of the composition of this example is: PEG-75 shea butter glycerides, phytosterol / octyldodecanol lauroyl glutamate, glyceryl glucoside, panthenol and glyceryl oleate are mixed to prepare the composition.

[0036] Example 2

[0037] A composition comprises the following components in parts by weight: 20 parts of PEG-75 shea butter glycerides, 30 parts of phytosterol / octyldodecanol lauroyl glutamate, 15 parts of glyceryl glucoside, 30 parts of panthenol and 5 parts of glyceryl oleate.

[0038] Example 3

[0039] A composition comprises the following components in parts by weight: 11 parts of PEG-75 shea butter glycerides, 40 parts of phytosterol / octyldodecanol lauroyl glutamate, 20 parts of glyceryl glucoside, 20 parts of panthenol and 9 parts of glyceryl oleate.

[0040] Example 4

[0041] A composition comprises the following components in parts by weight: 10 parts of PEG-75 shea butter glycerides, 30 parts of phytosterol / octyldodecanol lauroyl glutamate, 20 parts of glyceryl glucoside, 20 parts of panthenol and 20 parts of glyceryl oleate.

[0042] Example 5

[0043] A composition comprises the following components in parts by weight: 15 parts of PEG-75 shea butter glycerides, 30 parts of phytosterol / octyldodecanol lauroyl glutamate, 10 parts of glyceryl glucoside, 30 parts of panthenol and 15 parts of glyceryl oleate.

[0044] Example 6

[0045] A composition comprises the following components in parts by weight: 12 parts of PEG-75 shea butter glycerides, 33 parts of phytosterol / octyldodecanol lauroyl glutamate, 10 parts of glyceryl glucoside, 35 parts of panthenol and 10 parts of glyceryl oleate.

[0046] Example 7

[0047] A composition comprises the following components in parts by weight: 14 parts of PEG-75 shea butter glycerides, 30 parts of phytosterol / octyldodecanol lauroyl glutamate, 15 parts of glyceryl glucoside, 30 parts of panthenol and 11 parts of glyceryl oleate.

[0048] Example 8

[0049] A composition comprises the following components in parts by weight: 13 parts of PEG-75 shea butter glycerides, 35 parts of phytosterol / octyldodecanol lauroyl glutamate, 10 parts of glyceryl glucoside, 30 parts of panthenol and 12 parts of glyceryl oleate.

[0050] Example 9

[0051] A composition comprises the following components in parts by weight: 10 parts of PEG-75 shea butter glycerides, 32 parts of phytosterol / octyldodecanol lauroyl glutamate, 10 parts of glyceryl glucoside, 38 parts of panthenol and 10 parts of glyceryl oleate.

[0052] The preparation methods of the compositions of Examples 2-9 are the same as that of Example 1.

[0053] Comparative Examples 1-5

[0054] The difference from Example 1 is that Comparative Examples 1-5 all use one component, as shown in Table 1.

[0055] Table 1

[0056]

[0057] Comparative Example 6

[0058] Compared with Example 1, the difference is that the comparative example composition does not include PEG-75 shea butter glyceride, and the other components, amounts and preparation methods are the same as those in Example 1.

[0059] Comparative Example 7

[0060] Compared with Example 1, the difference is that the comparative example composition does not include phytosterol / octyldodecanol lauroyl glutamate, and the other components, amounts and preparation methods are the same as those in Example 1.

[0061] Comparative Example 8

[0062] Compared with Example 1, the difference is that the comparative example composition does not include glycerol glucoside, and the other components, amounts and preparation methods are the same as those in Example 1.

[0063] Comparative Example 9

[0064] Compared with Example 1, the difference is that the composition of this comparative example does not include panthenol, and the other components, amounts and preparation methods are the same as those of Example 1.

[0065] Comparative Example 10

[0066] Compared with Example 1, the difference is that the comparative example composition does not include glycerol oleate, and the other components, amounts and preparation methods are the same as those in Example 1.

[0067] Comparative Example 11

[0068] Compared with Example 1, the difference is that in this comparative example 11, PEG-75 shea butter glycerides are replaced with an equal amount of cetearyl alcohol polyether-20 with similar efficacy, and other components, addition amounts and preparation methods are the same as those in Example 1.

[0069] Comparative Example 12

[0070] Compared with Example 1, the difference is that in this comparative example 12, an equal amount of phytosterol / octyldodecanol lauroyl glutamate is replaced with jojoba oil with similar efficacy, and other components, addition amounts and preparation methods are the same as those in Example 1.

[0071] Comparative Example 13

[0072] Compared with Example 1, the difference is that in this comparative example 13, an equal amount of glycerol glucoside is replaced with trehalose with similar efficacy, and other components, addition amounts and preparation methods are the same as those in Example 1.

[0073] Comparative Example 14

[0074] Compared with Example 1, the difference is that in this comparative example 14, an equal amount of panthenol is replaced with allantoin with similar efficacy, and other components, addition amounts and preparation methods are the same as those in Example 1.

[0075] Comparative Example 15

[0076] Compared with Example 1, the difference is that in Comparative Example 15, an equal amount of glycerol oleate is replaced with caprylic acid / caprylic acid triglyceride of similar efficacy, and other components, addition amounts and preparation methods are the same as those in Example 1.

[0077] Comparative Example 16

[0078] Compared with Example 1, the difference is that Comparative Example 16 only contains PEG-75 shea butter glycerides and phytosterol / octyldodecanol lauroyl glutamate, and the added amount and preparation method are the same as those of Example 1.

[0079] Comparative Example 17

[0080] Compared with Example 1, the difference is that Comparative Example 17 only contains glycerol glucoside and glycerol oleate, and the added amount and preparation method are the same as those of Example 1.

[0081] Comparative Example 18

[0082] Compared with Example 1, the difference is that Comparative Example 18 only contains PEG-75 shea butter glycerides and panthenol, and the added amount and preparation method are the same as those of Example 1.

[0083] Comparative Example 19

[0084] Compared with Example 1, the difference is that Comparative Example 18 only contains phytosterol / octyldodecanol lauroyl glutamate and panthenol, and the added amount and preparation method are the same as those of Example 1.

[0085] Comparative Example 20

[0086] Compared with Example 1, the difference is that Comparative Example 20 only contains PEG-75 shea butter glycerides, phytosterol / octyldodecanol lauroyl glutamate, and panthenol, and the added amount and preparation method are the same as those of Example 1.

[0087] Comparative Example 21

[0088] Compared with Example 1, the difference is that Comparative Example 21 only contains glyceryl glucoside, panthenol, and glyceryl oleate, and the added amount and preparation method are the same as those of Example 1.

[0089] Comparative Example 22

[0090] Compared with Example 1, the difference is that Comparative Example 22 only contains phytosterol / octyldodecanol lauroyl glutamate, glyceryl glucoside, and glyceryl oleate, and the added amount and preparation method are the same as those of Example 1.

[0091] Comparative Example 23

[0092] Compared with Example 1, the difference is that Comparative Example 23 only contains PEG-75 shea butter glycerides, panthenol, and glyceryl oleate, and the added amount and preparation method are the same as those of Example 1.

[0093] Comparative Example 24

[0094] Compared with Example 1, the difference is that Comparative Example 24 only contains PEG-75 shea butter glycerides, panthenol, and glyceryl glucoside, and the added amount and preparation method are the same as those of Example 1.

[0095] Comparative Example 25

[0096] Compared with Example 1, the difference is that Comparative Example 25 only contains phytosterol / octyldodecanol lauroyl glutamate, panthenol, and glyceryl oleate, and the added amount and preparation method are the same as those of Example 1.

[0097] Application Example 1

[0098] A facial cleanser comprising the composition of the present invention, the formula of which is shown in Table 2.

[0099] Table 2

[0100]

[0101]

[0102] The preparation method of the facial cleanser of Application Example 1 is as follows:

[0103] 1. Add all the ingredients of phase A into an emulsifier, heat to 80°C, and then homogenize and stir evenly for 15 minutes. Keep warm for 10 minutes and then start cooling. Before cooling, add PEG-75 shea butter glycerides in phase E and stir evenly.

[0104] 2. Cool down to 65°C, add glycerol oleate in phase B and phase E respectively, stir homogenously for 20 minutes, and continue to cool down;

[0105] 3. Cool down to 50°C, slowly add phase C (pre-dispersed with 1.5 times the mass of deionized water), and stir evenly;

[0106] 4. Cool down to 40℃, add phytosterol / octyldodecanol lauroyl glutamate, panthenol, glyceryl glucoside in phase E, add appropriate amount of essence, and then adjust the pH to 6-7 with a pH adjuster.

[0107] Application Example 2

[0108] The difference from Application Example 1 is that the mass percentage of the composition in Example 1 is adjusted to 5%, and the other components, dosages and preparation methods are the same as those in Application Example 1.

[0109] Application Example 3

[0110] The difference from Application Example 1 is that the mass percentage of the composition in Example 1 is adjusted to 50%, and the other components, dosages and preparation methods are the same as those in Application Example 1.

[0111] Application Example 4

[0112] The difference from Application Example 1 is that the mass percentage of the composition in Example 1 is adjusted to 20%, and the other components, dosages and preparation methods are the same as those in Application Example 1.

[0113] Application Example 5

[0114] The difference from Application Example 1 is that the mass percentage of the composition in Example 1 is adjusted to 10%, and the other components, dosages and preparation methods are the same as those in Application Example 1.

[0115] Application Comparative Example 1

[0116] The difference between Application Comparative Example 1 and Application Example 1 is that Application Comparative Example 1 does not contain the composition of Example 1, and other components, dosages and preparation methods are the same as those of Application Example 1.

[0117] Application Comparative Example 2

[0118] The difference between Application Example 2 and Application Example 1 is that in Application Example 2, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 1, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0119] Application Comparative Example 3

[0120] The difference between Application Example 3 and Application Example 1 is that in Application Example 3, the composition of Example 1 is replaced by the composition of Comparative Example 2 in equal amounts, and the other components, addition amounts and preparation methods are the same as those in Application Example 1.

[0121] Application Comparative Example 4

[0122] The difference between Application Example 4 and Application Example 1 is that in Application Example 4, the composition of Example 1 is replaced by the composition of Comparative Example 3 in equal amounts, and the other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0123] Application Comparative Example 5

[0124] The difference between Application Example 5 and Application Example 1 is that in Application Example 5, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 4, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0125] Application Comparative Example 6

[0126] The difference between Application Example 6 and Application Example 1 is that in Application Example 6, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 5, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0127] Application Comparative Example 7

[0128] The difference between Application Example 7 and Application Example 1 is that in Application Example 7, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 6, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0129] Application Comparative Example 8

[0130] The difference between Application Example 8 and Application Example 1 is that in Application Example 8, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 7, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0131] Application Comparative Example 9

[0132] The difference between Application Example 9 and Application Example 1 is that in Application Example 9, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 8, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0133] Application Comparative Example 10

[0134] The difference between Application Example 10 and Application Example 1 is that in Application Example 10, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 9, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0135] Application Comparative Example 11

[0136] The difference between Application Example 11 and Application Example 1 is that in Application Example 11, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 10, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0137] Application Comparative Example 12

[0138] The difference between Application Example 12 and Application Example 1 is that in Application Example 12, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 11, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0139] Application Comparative Example 13

[0140] The difference between Application Example 13 and Application Example 1 is that in Application Example 13, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 12, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0141] Application Comparative Example 14

[0142] The difference between Application Example 14 and Application Example 1 is that in Application Example 14, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 13, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0143] Application Comparative Example 15

[0144] The difference between Application Example 15 and Application Example 1 is that in Application Example 15, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 14, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0145] Application Comparative Example 16

[0146] The difference between Application Example 16 and Application Example 1 is that in Application Example 16, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 15, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0147] Application Comparative Example 17

[0148] The difference between Application Example 17 and Application Example 1 is that in Application Example 17, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 16, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0149] Application Comparative Example 18

[0150] The difference between Application Example 18 and Application Example 1 is that in Application Example 18, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 17, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0151] Application Comparative Example 19

[0152] The difference between Application Example 19 and Application Example 1 is that in Application Example 19, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 18, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0153] Application Comparative Example 20

[0154] The difference between Application Example 20 and Application Example 1 is that in Application Example 20, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 19, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0155] Application Comparative Example 21

[0156] The difference between Application Example 21 and Application Example 1 is that in Application Example 21, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 20, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0157] Application Comparative Example 22

[0158] The difference between Application Example 22 and Application Example 1 is that in Application Example 22, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 21, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0159] Application Comparative Example 23

[0160] The difference between Application Example 23 and Application Example 1 is that in Application Example 23, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 22, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0161] Application Comparative Example 24

[0162] The difference between Application Example 24 and Application Example 1 is that in Application Example 24, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 23, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0163] Application Comparative Example 25

[0164] The difference between Application Example 25 and Application Example 1 is that in Application Example 25, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 24, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0165] Application Comparative Example 26

[0166] The difference between Application Example 26 and Application Example 1 is that in Application Example 26, an equal amount of the composition of Example 1 is replaced by the composition of Comparative Example 25, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0167] Product efficacy testing

[0168] Test Example 1 Patch test

[0169] Sample: the facial cleansing milk of Application Examples 1-5 and Application Comparative Examples 1-26.

[0170] Subjects: A total of 60 subjects, including 30 males and 30 females, aged 20-40 years old, were randomly divided into two groups (30 people in each group) who met the selection criteria for volunteer subjects.

[0171] Test method: A closed test method is used. The test article is placed in a suitable patch tester, which is applied to the subject's arm with a low-allergenic tape and lightly pressed with the palm of the hand to evenly apply it to the skin for 24 hours. The blank control group is a group in which the test article is not applied to the subject.

[0172] Result analysis: After 24 hours, the patch test tape was removed, and the skin reaction was observed after 30 minutes, 24 hours, and 48 hours, and the results of the skin reaction were recorded and analyzed according to the CTFA guidelines. The skin adverse reaction grades are shown in Table 3, and the test results are shown in Table 4.

[0173] Table 3

[0174]

[0175]

[0176] Table 4

[0177]

[0178]

[0179]

[0180]

[0181] From the data in Table 4, it can be seen that among the 30 subjects, no adverse skin reactions occurred in the application examples 1-5, application examples 3, application examples 4, application examples 5, application examples 6, application examples 7, application examples 8, application examples 9, application examples 11, application examples 13, application examples 14, application examples 15, application examples 16, application examples 19, application examples 20, application examples 21, application examples 22, application examples 24, and application examples 25; and there was 1 case of grade 1 adverse reaction in each of application examples 1, application examples 2, application examples 10, application examples 12, application examples 17, application examples 18, application examples 23, and application examples 26. It can be seen that the facial cleanser with the composition of the present invention added is more gentle, and the components in the composition of the present invention play a synergistic role after scientific compounding, reduce the irritation of surfactants, and are suitable for facial cleansing products.

[0182] Test Example 2 Determination of moisture content of the stratum corneum of the skin

[0183] Sample: the facial cleansing milk of Application Examples 1-5 and Application Comparative Examples 1-26.

[0184] Test method: 310 volunteers aged 18-30 were recruited (every 10 volunteers used the same sample). The subjects washed their faces with the product once a day in the morning and evening. Before use and on the 7th day after use, at a temperature of 21±1℃ and a humidity of 30±10%, the subjects cleaned their faces and waited for 20 minutes, then measured the facial moisture content, and comprehensively evaluated the moisturizing effect of the product on human skin.

[0185] Moisture content change rate: refers to the change rate of skin moisture content after using the product compared to before use. A positive value indicates an increase in moisture content and skin moisture, while a negative value indicates a decrease in moisture content and skin moisture.

[0186] The test results are shown in Table 5.

[0187] Table 5

[0188]

[0189]

[0190]

[0191] It can be understood that the larger the water content value, the higher the water content of the stratum corneum in the test area; and the smaller the water content value, the lower the water content of the stratum corneum in the test area.

[0192] The data in Table 5 show that the moisture content of Examples 1-5 on the 7th day after use was significantly improved, all of which were positive values; without the composition of the present invention, or lacking a single or multiple components in the composition of the present invention, or replacing the components in the composition of the present invention with other components (Comparative Examples 1-26), the moisture content was significantly reduced on the 7th day after use, all of which were negative values. It can be seen that the components in the composition of the present invention play a synergistic role after scientific compounding, and significantly improve the moisturizing effect.

[0193] Test Example 3 Skin Water Loss (TEWL Value) Test

[0194] Sample: the facial cleansing milk of Application Examples 1-5 and Application Comparative Examples 1-26.

[0195] Test method: 310 volunteers aged 18-30 were recruited (every 10 volunteers used the same sample) (the same volunteers as in Test Example 2). The subjects washed their faces with the product once a day in the morning and evening. Before use and on the 7th day after use, at a temperature of 21±1°C and a humidity of 30±10%, the subjects cleaned their faces and waited for 20 minutes, then measured the transepidermal water loss, and comprehensively evaluated the skin barrier function of the product on human skin.

[0196] The test results are shown in Table 6.

[0197] Table 6

[0198]

[0199]

[0200]

[0201] It can be understood that the higher the TEWL value, the more transepidermal water loss per unit time and unit cross-sectional area; the lower the TEWL value, the less transepidermal water loss per unit time and unit cross-sectional area.

[0202] The data in Table 6 show that when Examples 1-5 are used, the TEWL values ​​on the 7th day after use are all reduced and are all negative values; without adding the composition of the present invention, or lacking one or more components in the composition of the present invention, or replacing the components in the composition of the present invention with other components (Comparative Examples 1-26), the TEWL values ​​on the 7th day after use are increased instead, and are all positive values. Combined with the data analysis in Table 5, it is shown that the composition of the present invention has a repairing effect after scientific combination.

[0203] Test Example 4 Stability Test

[0204] The facial cleansers of Application Examples 1-5 were subjected to stability tests, and the results are shown in Tables 7, 8, and 9.

[0205] Table 7

[0206]

[0207] Table 8

[0208]

[0209]

[0210] Table 9

[0211]

[0212] It can be seen from the data in Tables 7-9 that the products of Application Examples 1-5 can pass the stability test under the conditions of -15°C, 5°C, room temperature (22°C±2), light, 48°C, and 40°C.

[0213] Test Example 5 Consumer Evaluation

[0214] Tested substances: the facial cleansers of Application Examples 1-5 and Comparative Example 2.

[0215] Subjects: 180 volunteers were recruited, divided into 6 groups with 30 subjects in each group, aged 18-40 years old.

[0216] Test method: The subjects used the product once to wash their faces on the spot. One hour later, they evaluated the skin condition after using the product through a questionnaire. The questionnaire included six aspects of evaluation, including no tightness after washing, skin becoming moisturized, improvement in skin irritation, slowing down of facial sebum secretion and deposition, foam richness, and personal preference. The evaluation standard was 10 points. Volunteers scored according to their own test experience. The higher the score, the stronger the characteristic of the item. The average value of the obtained data was taken as the result for analysis.

[0217] The results of the questionnaire are shown in Table 10.

[0218] Table 10

[0219]

[0220] It can be seen from Table 10 that the scores of each evaluation item of the facial cleansers of Application Examples 1-5 used in the test are higher than those of the test sample of Application Comparative Example 2, indicating that the effects in terms of skin moisturizing, soothing, foaming, etc. are recognized by the volunteers. At the same time, combined with other test results, a comprehensive analysis shows that the composition of the present invention has the effect of repairing the skin barrier, is gentler and more stable.

[0221] The preferred embodiments of the present invention are specifically described above, but the invention is not limited to the embodiments. Those skilled in the art can make various equivalent modifications or substitutions without violating the spirit of the invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A composition, It is characterized in that The composition includes the components: PEG-75 shea butter glycerides, phytosteryl / octyldodecanol lauroyl glutamate, glyceryl glucoside, panthenol and glyceryl oleate.

2. The composition according to claim 1, It is characterized in that The composition comprises the following components in parts by mass: 5-20 parts of PEG-75 shea butter glycerides, 20-40 parts of phytosterol / octyldodecanol lauroyl glutamate, 5-20 parts of glyceryl glucoside, 20-40 parts of panthenol and 5-20 parts of glyceryl oleate.

3. The composition according to claim 2, It is characterized in that The composition comprises the following components in parts by mass: 10-20 parts of PEG-75 shea butter glycerides, 30-40 parts of phytosterol / octyldodecanol lauroyl glutamate, 10-20 parts of glyceryl glucoside, 30-40 parts of panthenol and 10-20 parts of glyceryl oleate.

4. A method for preparing the composition according to any one of claims 1 to 3, It is characterized in that The following steps are involved: The components are mixed to obtain a composition.

5. Use of the composition according to any one of claims 1 to 3 in the preparation of a product for skin barrier repair.

6. A facial cleansing product, It is characterized in that The invention comprises the composition according to any one of claims 1 to 3.

7. The facial cleansing product according to claim 6, It is characterized in that The content of the composition is 0.01-50wt%.

8. The facial cleansing product according to claim 7, It is characterized in that The content of the composition is 5-50wt%.

9. The facial cleansing product according to claim 6, It is characterized in that The facial cleansing product further comprises at least one of a surfactant, a thickener, a pH regulator, a preservative and a chelating agent.

10. The facial cleansing product according to claim 6, It is characterized in that The facial cleansing product comprises any one of facial cleanser, facial cleansing milk, facial cleansing cream or facial cleansing mousse.

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