Body cavity water-soluble lubricant, preparation method and application

Abstract

The invention relates to the technical field of biological medicine, in particular to a body cavity water-soluble lubricant, a preparation method and application. According to the lubricant disclosed by the invention, glycerol, carbomer, xanthan gum, triethanolamine, polyethylene glycol, methylparaben, propylparaben and purified water are adopted as main components, all the contained components are soluble in water, all the components belong to safe medicinal materials and can be naturally discharged after being absorbed by a human body, and the safety of a patient cannot be influenced. Besides, polyethylene glycol with the character between fluid and solid is adopted, so that the lubricant is in a semi-flowing state, the lubricant can keep a relatively stable shape, is not easy to flow, is convenient to operate, has proper flowability, is easy to push away, and is beneficial to the realization of the lubricating effect of the lubricant. The alkalescence of triethanolamine is used for adjusting the PH value of the lubricant, and compared with the mode that sodium hydroxide and other strong bases are used for adjusting PH, the mode that triethanolamine is used for adjusting PH is milder, and the lubricant is more friendly to the human body.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technology, and in particular to a body cavity water-soluble lubricant, a preparation method and application thereof. Background Art

[0002] This section is intended to provide a background or context to the embodiments of the invention recited in the claims. No admission is made that the description herein is prior art by inclusion in this section.

[0003] Lubricants used in the human body cavity can effectively reduce the friction of instruments or other objects in the human body, reduce damage and discomfort to the human body, and are currently widely used in medical examinations and midwifery, as well as in people's daily lives.

[0004] This kind of application demand is commonly seen in the field of adult products, etc. In medicine, it is often seen in medical devices in interventional examinations that enter the human body for necessary examinations, as well as obstetrics and gynecology. When pregnant women give birth, the strong impact of uterine contractions tries to push the baby out. This process is often accompanied by dryness and friction in the birth canal, which brings considerable pain and discomfort to pregnant women. However, the excellent lubricating properties of midwifery gel can effectively reduce friction, provide a smooth passage for the birth canal, effectively reduce labor resistance, effectively shorten the delivery process, reduce maternal pain, and reduce the risk of maternal and fetal dangers, allowing them to welcome the arrival of the baby more calmly. However, the lubricants for instrument introduction currently used in hospitals generally use water-insoluble ingredients such as paraffin, vaseline, and silicone oil; the use of petroleum-based ingredients will destroy the latex structure of inspection catheters, gloves, etc.

[0005] Therefore, the prior art needs further improvement. Summary of the invention

[0006] The purpose of the present invention is to provide a body cavity water-soluble lubricant, a preparation method and an application thereof in order to solve the above-mentioned technical problems, so as to avoid the harm of non-water-soluble lubricants to the human body or inspection equipment.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is as follows.

[0008] On the one hand, the present invention provides a body cavity water-soluble lubricant, whose ingredients include: 8%-13% glycerol, 0.7%-1.2% carbomer, 0.1%-0.5% xanthan gum, 0.03%-0.08% polyethylene glycol, 0.1%-1.5% triethanolamine, 0.005%-0.015% methylparaben, 0.005%-0.015% propylparaben, 80%-90% purified water, and the percentages of the above components are mass percentages.

[0009] As a further solution, the lubricant includes 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.05% polyethylene glycol, 0.01% methylparaben, 0.01% propylparaben, and 88.03% purified water, and the percentages of the above components are by mass.

[0010] As a further solution, the pH value of the lubricant is between 5-6.

[0011] As a further solution, the molecular weight of the polyethylene glycol is 500-800.

[0012] As a further solution, the lubricant includes 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.03% polyethylene glycol 400, 0.02% polyethylene glycol 800, 0.01% methylparaben, 0.01% propylparaben, and 88.03% purified water, and the percentages of the above components are mass percentages.

[0013] On the other hand, the present invention also provides a method for preparing a body cavity water-soluble lubricant, comprising the following steps: taking 0.03%-0.08% polyethylene glycol by weight in a clean configuration container, adding 60%-70% purified water, heating to 70°C-75°C, stirring until dissolved, and setting aside; weighing 0.1%-1.5% triethanolamine by weight, adding it to the dissolved polyethylene glycol solution, stirring until the triethanolamine is dissolved and in a uniform state, and weighing 0. Add 7%-1.2% carbomer to the preparation container and stir until dissolved. Heat the solution to 90°C-100°C, weigh 0.005%-0.015% methylparaben and 0.005%-0.015% propylparaben respectively and add them to the preparation container, stir thoroughly until the solution is uniform, weigh 8%-13% glycerol and add it to the container, weigh 20%-30% purified water to rinse the glycerol weighing container and add it to the preparation container, stir thoroughly until the solution is uniform.

[0014] In some embodiments, the ratio of the components in the method is: 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.05% polyethylene glycol, 0.01% methylparaben, 0.01% propylparaben, 88.03% purified water, and the above component percentages are mass percentages.

[0015] In some embodiments, the ratio of the components in the method is: 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.03% polyethylene glycol 400, 0.02% polyethylene glycol 800, 0.01% methylparaben, 0.01% propylparaben, 88.03% purified water, and the percentages of the above components are mass percentages.

[0016] In some embodiments, the method of taking 0.03%-0.08% polyethylene glycol by weight, adding 60%-70% purified water, and stirring until dissolved includes weighing 0.03% polyethylene glycol 400, adding 60%-70% purified water, stirring until completely dissolved, and then adding 0.02% polyethylene glycol 800, and continuing to stir until completely dissolved.

[0017] In another aspect, the present invention also provides the use of the above-mentioned body cavity water-soluble lubricant in medical examination or midwifery.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] Lubricant of the present invention adopts glycerol, carbomer, xanthan gum, triethanolamine, polyethylene glycol, methylparaben, propylparaben and purified water as main component, and the contained ingredients are all soluble in water, and the above are all safe medicinal materials, and can be naturally discharged after human body absorption, and can not affect patient safety. In addition, the present invention adopts the polyethylene glycol between fluid and solid, so that the properties of lubricant are semi-fluid state, can keep relatively stable shape, not easy to flow, convenient operation, and possess suitable fluidity again, be easy to push away, be conducive to the realization of lubricant lubrication effect. Utilize the weak alkalinity of triethanolamine to regulate the pH value of lubricant, compare strong bases such as sodium hydroxide to regulate pH, triethanolamine regulates pH more gentle, also more friendly to human body. DETAILED DESCRIPTION

[0020] In order to make the purpose, technical solution and advantages of the present invention more clear, the present invention is further described in detail. The exemplary embodiments of the present invention and their description are only used to explain the present invention and are not intended to limit the present invention. It should be noted that the present invention is already in the actual research and development stage.

[0022] Unless explicitly stated otherwise, throughout the specification and claims, the term “comprise” or variations such as “include” or “comprising”, etc., will be understood to include the stated elements or components but not to exclude other elements or components.

[0023] The present invention aims to solve the problem that existing body cavity lubricants are insoluble in water and provides a body cavity water-soluble lubricant, a preparation method and an application. When the lubricant of the present invention is used in medicine, it mainly solves the pain and discomfort of patients during microscopic examination and increases the one-time success rate of microscopic surgery. The water-soluble solvent reduces the damage to the instrument; it reduces the pain of childbirth during the midwifery process and can also shorten the time of childbirth; the childbirth process becomes smoother and more efficient.

[0024] The lubricant of the present invention adopts glycerin, carbomer, xanthan gum, triethanolamine, polyethylene glycol, methylparaben, propylparaben and purified water as main components, all of which are soluble in water and are safe medicinal materials. They will be naturally discharged after being absorbed by the human body and will not affect the safety of patients.

[0025] The xanthan gum used in the lubricant of the present invention, also known as xanthan gum, is a kind of microbial extracellular polysaccharide with wide functions produced by fermentation engineering of Xanthomnas campestris with carbohydrate as the main raw material (such as corn starch). It has unique rheological properties, good water solubility, stability to heat and acid and alkali, and good compatibility with various salts. As a thickener, suspending agent, emulsifier, stabilizer, it can be widely used in more than 20 industries such as food, petroleum, and medicine. It is the microbial polysaccharide with the largest production scale and extremely wide application in the world. Due to its strong hydrophilicity and water retention, it also has many specific medical operation applications, such as forming a dense water film to avoid skin infection; reducing the thirst of patients after radiotherapy, etc. And studies have shown that xanthan gum itself has a significant enhancing effect on the humoral immune function of mice.

[0026] The carbomer used in the lubricant of the present invention is also called carbomer, which is an acrylic acid cross-linked resin obtained by cross-linking pentaerythritol and acrylic acid. It is a very important rheological modifier. The neutralized carbomer is an excellent gel matrix with important uses such as thickening and suspension. It has simple process and good stability and is widely used in emulsions, creams and gels. The present invention adopts carbomer as a rheological modifier so that the rheological properties of the lubricant are between fluid and solid, which is convenient to operate and does not affect the realization of the lubricating effect of the lubricant. The carbomer of the present invention adopts Carbopol series, Carbopol AQUA SF series, carbopol Ultrez series or Pemulen TR series, which can be freely selected according to different use requirements.

[0027] The triethanolamine used in the lubricant of the present invention, namely tri(2-hydroxyethyl)amine, is an organic compound and can be regarded as a trihydroxy substitution product of triethylamine, with a chemical formula of C6H15NO3. Similar to other amine compounds, triethanolamine has weak alkalinity due to the presence of lone pair electrons on the nitrogen atom, and its alkalinity is weaker than that of ammonia (pKa=7.82). It has the properties of tertiary amine and alcohol and can react with inorganic acid or organic acid to form salt. The addition of triethanolamine to the lubricant of the present invention can adjust the pH value of the lubricant due to its weak alkalinity. Compared with adjusting the pH value by strong bases such as sodium hydroxide, adjusting the pH value by triethanolamine is more gentle and more friendly to the human body.

[0028] The polyethylene glycol used in the lubricant of the present invention is a high molecular polymer with a chemical formula of HO(CH2CH2O)nH, which is non-irritating, slightly bitter, has good water solubility, and has good compatibility with many organic components. It has excellent lubricity, moisture retention, dispersibility, and adhesion, and can be used as an antistatic agent and softener, and is widely used in industries such as cosmetics, pharmaceuticals, chemical fibers, rubber, plastics, papermaking, paints, electroplating, pesticides, metal processing, and food processing. The present invention can effectively keep the lubricant moist, lock the lubricant moisture, and prevent water loss through the excellent water solubility of polyethylene glycol.

[0029] Methylparaben and propylparaben are mostly used as preservatives in cosmetics. The lubricant of the present invention uses methylparaben and propylparaben in combination. While playing an antiseptic role and extending the shelf life, the difference in molecular weight and water solubility between the two complement each other to achieve compatibility between the oil phase and the water phase in the lubricant, which can further improve the uniformity and stability of the properties of the lubricant.

[0030] Regarding the ratios of the above components, the present invention studies the differences in lubricants formed by the components at different ratios. The present invention is described in detail below through specific embodiments.

[0031] Example 1

[0032] The present embodiment provides a body cavity water-soluble lubricant, whose ingredients include: 8%-13% glycerol, 0.7%-1.2% carbomer, 0.1%-0.5% xanthan gum, 0.03%-0.08% polyethylene glycol, 0.1%-1.5% triethanolamine, 0.005%-0.015% methylparaben, 0.005%-0.015% propylparaben, 80%-90% purified water, and the above component percentages are mass percentages.

[0033] The carbomer model used in this embodiment can be Carbopol 940 or Carbopol 941. Carbopol 940 has short rheology, high viscosity, high clarity, low ion resistance and shear resistance, and is suitable for gels and creams. Carbopol 941: long rheology, low viscosity, high clarity, medium ion resistance and shear resistance, suitable for gels and emulsions. Polyethylene glycol has different properties depending on its molecular weight, ranging from colorless and odorless viscous liquid to waxy solid. Polyethylene glycol with a molecular weight of 200 to 600 is liquid at room temperature, and a molecular weight of more than 600 gradually becomes semi-solid. The molecular weight of the polyethylene glycol used in this embodiment is 500-800, and its properties are between liquid and solid, so that the shape of the lubricant is between liquid and solid.

[0034] The present embodiment also provides a method for preparing the above-mentioned body cavity water-soluble lubricant, comprising the following steps: taking 0.03%-0.08% polyethylene glycol by weight in a clean preparation container, adding 60%-70% purified water, heating to 70°C-75°C, stirring until dissolved, and setting aside; weighing 0.1%-1.5% triethanolamine by weight, adding it to the dissolved polyethylene glycol solution, stirring until the triethanolamine is dissolved and in a uniform state, and weighing 0.7% -1.2% carbomer is added to the preparation container and stirred until dissolved, the solution is heated to 90°C-100°C, 0.005%-0.015% methylparaben and 0.005%-0.015% propylparaben are weighed and added to the preparation container, and stirred sufficiently until the solution is uniform, 8%-13% glycerol is weighed and added to the container, and 20%-30% purified water is weighed to rinse the glycerol weighing container and then added to the preparation container, and stirred sufficiently until the solution is uniform. In the above steps, in the step of adding triethanolamine, the amount of triethanolamine is controlled so that the pH of the lubricant is between 5 and 6.

[0035] On the other hand, this embodiment also provides the application of the above-mentioned body cavity water-soluble lubricant in medical examination or midwifery. The above-mentioned body cavity water-soluble lubricant provided in this embodiment has extremely strong water solubility, and the ingredients are safe and non-toxic. It will be naturally excreted after being absorbed by the human body, and will not affect the safety of the patient. It can be safely used in medical examination or midwifery, solve the pain and discomfort of patients during microscopic examination, increase the one-time success rate of microscopic surgery, and the water-soluble solvent reduces the damage of the instrument; it can reduce the pain of childbirth during midwifery, and can also shorten the time of childbirth; the childbirth process becomes smoother and more efficient.

[0036] The lubricant of the present embodiment adopts methylparaben and propylparaben for use, which play an antiseptic role and extend the shelf life. The difference in molecular weight and water solubility between the two complement each other to achieve the compatibility of the oil phase and the water phase in the lubricant, and can further improve the uniformity and stability of the properties of the lubricant. In actual work, in order to meet different needs, it is not limited to the use of the above two. In practice, other molecular weights or substances with equivalent functional groups can also be selected according to product or application requirements to improve the applicability of the product.

[0037] Example 2

[0038] This embodiment provides a specific lubricant composition ratio based on the above embodiment 1. The lubricant of this embodiment includes 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.05% polyethylene glycol, 0.01% methylparaben, 0.01% propylparaben, and 88.03% purified water, and the above component percentages are mass percentages. The molecular weight of the polyethylene glycol used in this embodiment is 500.

[0039] By controlling the amount of triethanolamine, the pH value of the lubricant is adjusted to between 5 and 6. In this embodiment, the amount of triethanolamine used is 0.6%, and the pH value of the lubricant can be adjusted to about 5.3, which is suitable for the human body environment.

[0040] The preparation method of the body cavity water-soluble lubricant of this embodiment comprises the following steps: in a clean configuration container, take 0.05% polyethylene glycol by weight, add 65% purified water, heat to 70°C-75°C, stir until dissolved, and set aside; weigh 0.6% triethanolamine by weight, add to the dissolved polyethylene glycol solution, stir until the triethanolamine is dissolved and in a uniform state, weigh 1% carbomer according to the metering amount and add to the configuration container, stir until dissolved, heat the solution to 90°C-100°C, weigh 0.01% methylparaben and 0.01% propylparaben respectively and add to the configuration container, stir fully until the solution is in a uniform state, weigh 10% glycerol and add to the container, weigh 23.03% purified water to rinse the glycerol weighing container and add to the configuration container, stir fully until the solution is in a uniform state. In the above steps, in the step of adding triethanolamine, the amount of triethanolamine is controlled so that the pH of the lubricant is between 5.3.

[0041] Example 3

[0042] In this embodiment, based on the above-mentioned embodiment 2, two kinds of polyethylene glycol are used in combination. The lubricant of this embodiment includes 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.03% polyethylene glycol 400, 0.02% polyethylene glycol 800, 0.01% methylparaben, 0.01% propylparaben, and 88.03% purified water, and the above-mentioned component percentages are mass percentages.

[0043] The preparation method of the water-soluble lubricant for body cavity of this embodiment comprises the following steps: in a clean preparation container, weigh 0.03% polyethylene glycol 400, add 60%-70% purified water, stir until completely dissolved, then add 0.02% polyethylene glycol 800, continue to stir until completely dissolved, and set aside; weigh 0.6% triethanolamine by weight, add it to the dissolved polyethylene glycol solution, stir until the triethanolamine is dissolved and in a uniform state, weigh 1% carbomer according to the metered amount, add it to the preparation container, stir until dissolved, heat the solution to 90°C-100°C, weigh 0.01% methylparaben and 0.01% propylparaben respectively, add them to the preparation container, stir thoroughly until the solution is in a uniform state, weigh 10% glycerol and add it to the container, then weigh 23.03% purified water to rinse the glycerol weighing container and add it to the preparation container, stir thoroughly until the solution is in a uniform state. In the above steps, in the step of adding triethanolamine, the amount of triethanolamine is controlled so that the pH of the lubricant is between 5.3.

[0044] The order of adding the two polyethylene glycols in this embodiment is not limited to the above order, and the order of adding the two polyethylene glycols can be adjusted according to the actual operation. The polyethylene glycol in this embodiment is not limited to the above two types, and other types of polyethylene glycol can be selected according to product or application requirements in practice, which can be three, four or more types, and the molecular weight is not limited to the above 400 or 800, and can be polyethylene glycol of other molecular weight levels, thereby improving the applicability of the product.

[0045] Example 4

[0046] This embodiment is used as a comparative embodiment of Example 3. This embodiment adopts a polyethylene glycol combination different from that of Example 3, and polyethylene glycol 300 and polyethylene glycol 1000 are used in combination. The lubricant of this embodiment includes 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.03% polyethylene glycol 300, 0.02% polyethylene glycol 1000, 0.01% methylparaben, 0.01% propylparaben, and 88.03% purified water, and the percentages of the above components are mass percentages.

[0047] The preparation method of the body cavity water-soluble lubricant of this embodiment comprises the following steps: in a clean preparation container, weigh 0.03% polyethylene glycol 300, add 60%-70% purified water, stir until completely dissolved, then add 0.02% polyethylene glycol 1000, continue to stir until completely dissolved, and set aside; weigh 0.6% triethanolamine by weight, add it to the dissolved polyethylene glycol solution, stir until the triethanolamine is dissolved and in a uniform state, weigh 1% carbomer according to the metered amount, add it to the preparation container, stir until dissolved, heat the solution to 90°C-100°C, weigh 0.01% methylparaben and 0.01% propylparaben respectively, add them to the preparation container, stir thoroughly until the solution is in a uniform state, weigh 10% glycerol and add it to the container, then weigh 23.03% purified water to rinse the glycerol weighing container and add it to the preparation container, stir thoroughly until the solution is in a uniform state. In the above steps, in the step of adding triethanolamine, the amount of triethanolamine is controlled so that the pH of the lubricant is between 5.3.

[0048] Example 5

[0049] The present embodiment is used as the comparative example of the above embodiment, and sodium hydroxide is used as the pH adjusting agent. The lubricant of the present embodiment comprises 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.3% sodium hydroxide solution, 0.05% polyethylene glycol, 0.01% methylparaben, 0.01% propylparaben, 88.03% purified water, and the above-mentioned component percentage is mass percentage. By titration with sodium hydroxide standard solution, the pH value of the lubricant is about 5.3. The present embodiment sodium hydroxide standard solution consumption 0.3%, the pH value of the lubricant can be adjusted to about 5.3, is suitable for human body environment.

[0050] In terms of the preparation method, the preparation method of the water-soluble lubricant for body cavity of this embodiment includes the following steps: in a clean preparation container, take 0.05% polyethylene glycol by weight, add 65% purified water, heat to 70°C-75°C, stir until dissolved, and set aside; weigh 1% carbomer according to the metered amount and add it to the preparation container, stir until dissolved, heat the solution to 90°C-100°C, weigh 0.01% methylparaben and 0.01% propylparaben respectively and add them to the preparation container, stir well until the solution is uniform, weigh 10% glycerol and add it to the container, weigh 23.03% purified water to rinse the glycerol weighing container and add it to the preparation container, stir well until the solution is uniform.

[0051] Prepare a sodium hydroxide standard solution, wait until the above solution is completely dissolved and stabilized, and then use the prepared sodium hydroxide standard solution to titrate until the pH value of the lubricant is 5.3, calculate the amount of sodium hydroxide solution, and the amount of sodium hydroxide standard solution used in this embodiment is 0.3%.

[0052] In order to study the effects of different formulations and components on the performance of the lubricant of the present invention, especially the effects of using a single polyethylene glycol and two polyethylene glycols in combination, and the effects of polyethylene glycols of different molecular weights selected when used in combination on the uniformity and stability of the lubricant, the lubricants obtained in the above examples were compared in properties, and the results are shown in Table 1:

[0053] Table 1 Comparison of water-soluble lubricants in body cavity with different components and ratios

[0054] category Characteristics Example 2 The lubricant is uniform and a small amount of water is precipitated after standing for 30 months Example 3 The lubricant is uniform and no water is precipitated after standing for 40 months Example 4 The lubricant is uniform and a small amount of water is precipitated after standing for 25 months Example 5 The lubricant is relatively uniform, and water precipitates after standing for 8 months

[0055] The comparison results in the above table show that the lubricant obtained by using polyethylene glycol with a molecular weight of 400 and a molecular weight of 800 in Example 3 has the best shape, and the stability of the single polyethylene glycol with a molecular weight of 500 in Example 2 is also good, while the shape of the lubricant obtained by using polyethylene glycol with a molecular weight of 300 and a molecular weight of 1000 in Example 4 is relatively poor. It can be seen that the lubricant obtained by using polyethylene glycol with a molecular weight between 500 and 800 has better stability than the lubricant obtained by using polyethylene glycol with a molecular weight of too large or too small or a combination of the two. If a single molecular weight polyethylene glycol is used, polyethylene glycol with a molecular weight close to 600 should be selected as much as possible, because the properties of polyethylene glycol with this molecular weight are between fluid and solid, which is more suitable for lubricants, so that the properties of the lubricant are in a semi-fluid state, which can maintain a relatively stable shape, not easy to flow, and convenient to operate, and has suitable fluidity and is easy to push away, thereby avoiding affecting the lubricating effect of the lubricant.

[0056] In the above embodiments of the present application, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, please refer to the relevant description of other embodiments.

[0057] It should be noted that, for the above-mentioned embodiments, for the sake of simplicity, they are all expressed as a series of action combinations, but those skilled in the art should be aware that the present application is not limited by the described order of actions, because according to the present application, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all preferred embodiments, and the actions and modules involved are not necessarily required by the present application.

[0058] The above specific implementation methods further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific implementation method of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A body cavity water-soluble lubricant, characterized in that: The ingredients include: 8%-13% glycerol, 0.7%-1.2% carbomer, 0.1%-0.5% xanthan gum, 0.03%-0.08% polyethylene glycol, 0.1%-1.5% triethanolamine, 0.005%-0.015% methylparaben, 0.005%-0.015% propylparaben, and 80%-90% purified water, and the above component percentages are mass percentages.

2. A body cavity water-soluble lubricant according to claim 1, characterized in that: The lubricant comprises 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.05% polyethylene glycol, 0.01% methylparaben, 0.01% propylparaben and 88.03% purified water, and the percentages of the above components are by mass.

3. A body cavity water-soluble lubricant according to claim 2, characterized in that: The pH value of the lubricant is between 5 and 6.

4. The body cavity water-soluble lubricant according to claim 2, characterized in that: The molecular weight of the polyethylene glycol is 500-800.

5. The body cavity water-soluble lubricant according to claim 4, characterized in that: The lubricant comprises 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.03% polyethylene glycol 400, 0.02% polyethylene glycol 800, 0.01% methylparaben, 0.01% propylparaben and 88.03% purified water, and the above component percentages are mass percentages.

6. A method for preparing a body cavity water-soluble lubricant, characterized in that: The following steps are involved: In a clean preparation container, 0.03%-0.08% polyethylene glycol by weight is taken, 60%-70% purified water is added, and the mixture is heated to 70°C-75°C, stirred until dissolved, and set aside; 0.1%-1.5% triethanolamine by weight is weighed, added to the dissolved polyethylene glycol solution, and stirred until the triethanolamine is dissolved and in a uniform state; 0.7%-1.2% carbomer is weighed according to the metered amount and added to the preparation container, and stirred until dissolved; the solution is heated to 90°C-100°C; 0.005%-0.015% methylparaben and 0.005%-0.015% propylparaben are weighed respectively and added to the preparation container, and stirred sufficiently until the solution is in a uniform state; 8%-13% glycerol is weighed and added to the container; 20%-30% purified water is weighed to rinse the glycerol weighing container, and then added to the preparation container, and stirred sufficiently until the solution is in a uniform state.

7. The method for preparing the body cavity water-soluble lubricant according to claim 6, characterized in that: The proportions of the components in the method are: 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.05% polyethylene glycol, 0.01% methylparaben, 0.01% propylparaben, and 88.03% purified water, and the percentages of the above components are by mass.

8. The method for preparing the body cavity water-soluble lubricant according to claim 7, characterized in that: The proportions of the components in the method are: 10% glycerol, 1% carbomer, 0.3% xanthan gum, 0.6% triethanolamine, 0.03% polyethylene glycol 400, 0.02% polyethylene glycol 800, 0.01% methylparaben, 0.01% propylparaben, and 88.03% purified water, and the percentages of the above components are mass percentages.

9. The method for preparing the body cavity water-soluble lubricant according to claim 8, characterized in that The method comprises taking 0.03%-0.08% polyethylene glycol by weight, adding 60%-70% purified water, and stirring until dissolved, weighing 0.03% polyethylene glycol 400, adding 60%-70% purified water, stirring until completely dissolved, and then adding 0.02% polyethylene glycol 800, and continuing to stir until completely dissolved.

10. Use of the body cavity water-soluble lubricant according to any one of claims 1 to 9 in medical examination or midwifery.