Periorbital acupoint'acupuncture 'flexible ultrasonic patch for relieving asthenopia and preparation method of periorbital acupoint'acupuncture' flexible ultrasonic patch

Abstract

The invention discloses a periorbital acupoint'acupuncture 'flexible ultrasonic patch for relieving asthenopia and a preparation method thereof. The periorbital acupoint'acupuncture' flexible ultrasonic patch comprises a flexible adhesion layer, a flexible packaging layer, an ultrasonic module, a positive / negative flexible circuit and a flexible substrate layer, the positive / negative flexible circuit respectively comprises an upper polyimide protection layer, a stretchable snake-shaped wire and a lower polyimide protection layer; the ultrasonic module is composed of a piezoelectric device, a matching layer and positive / negative metal electrodes, and the positive and negative metal electrodes are located on the same side of the piezoelectric plate and electrically communicated with the positive and negative flexible circuits respectively; the positive electrode flexible circuit and the negative electrode flexible circuit are electrically communicated with a positive electrode and a negative electrode of the adjustable alternating current power supply respectively, the adjustable alternating current power supply synchronously excites the ultrasonic module, and the effect of relieving asthenopia is achieved by stimulating corresponding acupuncture points around eyes. The flexible ultrasonic patch is light in weight and portable, is tightly attached to the skin around the eyes, can be used for seeing objects with eyes in the using process, and greatly facilitates life of people while promoting eye health.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and in particular relates to a flexible ultrasonic patch for "acupuncture" of acupoints around the eyes for relieving visual fatigue and a preparation method thereof. Background Art

[0002] Visual fatigue, or eye strain, is a common eye disease. The dry eyes, sore eyes, sore eyes, blurred vision and even decreased vision it causes directly affect people's work and life, and can also trigger and aggravate various eye diseases.

[0003] Currently, commonly used treatment methods include drug therapy and non-drug therapy. Drug therapy includes the use of artificial tears, eye drops and other methods, which will cause a certain degree of discomfort during use. Non-drug treatments include acupuncture, acupoint massage and other methods. Commonly used acupoints are Zuanzu point, temple, Jingming point and Sibai point. Among them, acupuncture is an invasive method. The acupoints around the eyes are closer to the eyeballs and have greater risks. It is necessary to go to the hospital for treatment by professionals; acupoint massage, such as eye exercises, has been widely popularized as a non-invasive method, but this method requires a period of dedicated time for self-massage.

[0004] Ultrasound has attracted wide attention in recent years as a non-invasive treatment method. Studies have shown that ultrasound of a certain frequency and intensity can be used to regulate central and peripheral nerves and has a positive effect on acupoint stimulation. Among them, focused ultrasound can produce short-term stimulation to acupoints through mechanical action and thermal effect, and low-intensity pulsed ultrasound can also achieve stimulation of acupoints through long-term energy deposition of mechanical action.

[0005] Traditional ultrasound equipment uses rigid probes, which are large and difficult to carry, and difficult to achieve conformal contact with the body surface. The pressing operation during use will cause discomfort to the patient. Flexible ultrasound devices are an emerging electronic device that is lightweight and portable, can conform to various complex surfaces, and only need to be gently attached when used, and no hands are required for subsequent processes. Therefore, flexible ultrasound devices make up for the shortcomings of traditional treatment methods and traditional rigid ultrasound probes, and have broad application prospects in the field of periocular acupoint stimulation.

[0006] The technical problem that urgently needs to be solved by technicians in this field is how to make a flexible ultrasonic device that is patient-friendly, lightweight and portable, and can specifically stimulate the acupuncture points around the eyes that are related to relieving eye fatigue. Summary of the invention

[0007] To solve the above problems, the present invention proposes a flexible ultrasonic patch for relieving visual fatigue by "acupuncture" of periocular acupoints and a preparation method thereof. The flexible ultrasonic patch is light and portable, can be tightly attached to the periocular area, and can achieve the effect of relieving visual fatigue in daily life by non-invasively stimulating periocular acupoints.

[0008] The present invention provides a flexible ultrasonic patch for "acupuncture" of periocular acupoints for relieving visual fatigue. The flexible ultrasonic patch comprises, from top to bottom, a flexible adhesion layer, a flexible packaging layer, an ultrasonic module, a positive / negative flexible circuit, and a flexible substrate layer.

[0009] The positive / negative flexible circuits respectively comprise an upper polyimide protective layer, a stretchable serpentine conductor, and a lower polyimide protective layer.

[0010] The flexible adhesive layer is used to achieve close fitting of the flexible ultrasonic patch and the skin around the eye.

[0011] The positive flexible circuit and the negative flexible circuit are electrically connected to the positive electrode and the negative electrode of the adjustable AC power supply respectively. The adjustable AC power supply synchronously excites the ultrasonic module to achieve the effect of relieving visual fatigue by stimulating the corresponding acupuncture points around the eyes.

[0012] In the above technical solution, preferably, the ultrasonic module is composed of a piezoelectric device, a matching layer, a positive metal electrode, and a negative metal electrode; a negative metal electrode is provided on the lower surface of the piezoelectric device, and a positive metal electrode is provided on the upper surface; the positive metal electrode is a flanged electrode, extending to the same side as the negative metal electrode, thereby realizing single-sided welding with the positive / negative flexible circuit; one side of the matching layer is bonded to the flexible packaging layer, and the other side is bonded to the positive metal electrode.

[0013] Furthermore, the piezoelectric device is a 1-3 type piezoelectric composite material or a piezoelectric ceramic, and the matching layer is a composite material formed by doping nano-metal powder or nano-metal oxide powder into epoxy resin.

[0014] Preferably, the lower surface of the stretchable serpentine wire is completely wrapped by the lower polyimide protective layer, and the upper surface is partially wrapped by the upper polyimide protective layer and exposes the welding point position; the welding point position is used to coat the conductive adhesive layer, and the conductive adhesive layer is used to realize the connection between the stretchable serpentine wire in the positive flexible circuit and the negative flexible circuit and the positive metal electrode and the negative metal electrode.

[0015] Furthermore, the conductive adhesive layer is conductive silver paste, low-temperature solder paste or conductive composite material.

[0016] Preferably, the positive / negative flexible circuits are stacked at corresponding positions by a transfer process, and the stretchable serpentine conductors in the positive / negative flexible circuits are separated by the lower polyimide protective layer and the upper polyimide protective layer.

[0017] Preferably, there are 4 groups of ultrasound modules, each having the same natural frequency and connected in parallel, and each attached to the projection of the periocular acupuncture points on the body surface.

[0018] Preferably, the positive flexible circuit and the negative flexible circuit are electrically connected to the positive electrode and the negative electrode of the adjustable AC power supply through a flat cable.

[0019] Preferably, the flexible adhesive layer is a medical adhesive, a hydrogel or an uncured silicone.

[0020] Preferably, the flexible encapsulation layer and the flexible substrate layer are PDMS or Eco-flex.

[0021] Preferably, the adjustable AC power supply transmission frequency is 1-3 MHz.

[0022] Preferably, the present invention also provides a customized mold for the overall assembly of a flexible ultrasonic patch, which is used to realize the preparation of the flexible ultrasonic patch; the mold includes a bottom layer mold, a substrate layer mold, a packaging layer mold, an adhesion layer mold, and positioning pins for positioning each layer of the mold from bottom to top.

[0023] Furthermore, the bottom layer mold and the encapsulation layer mold are made of acrylic.

[0024] Furthermore, the substrate layer mold and the adhesion layer mold are made of stainless steel.

[0025] Preferably, the method for preparing the flexible ultrasonic patch comprises the following steps: 1) Preparation of flexible circuits: preparing the upper polyimide protective layer, the stretchable serpentine conductor, and the lower polyimide protective layer by micro-nano processing methods; 2) Overall assembly of the device: Use a customized mold to assemble the flexible ultrasound patch: a. With the assistance of positioning pins, assemble the substrate layer mold on the bottom mold, pour the precursor of the flexible substrate layer and heat and cure; b. transferring the positive / negative flexible circuit to the flexible substrate layer, coating the conductive adhesive layer at the solder joints of the positive / negative flexible circuit, and welding the wiring at the exposed solder joints at the ends of the positive / negative flexible circuit by a hot pressing process; c. connecting the ultrasonic module to the positive / negative flexible circuit through the conductive adhesive layer; d. Assemble the encapsulation layer mold, pour the precursor of the flexible encapsulation layer and heat and cure it to achieve the overall encapsulation of the flexible ultrasonic circuit; e. Assembling the adhesive layer mold, pouring the precursor of the flexible adhesive layer and heating and curing; 3) releasing the flexible ultrasonic patch and connecting it to an adjustable AC power source via a flat cable.

[0026] The above technical solution provided by the present invention has at least the following beneficial effects:

[0027] The flexible ultrasonic device of the present invention conforms well to human skin, is lightweight, portable, and comfortable to wear, solving the problems of rigid probes being bulky, not suitable for fitting to human skin, and uncomfortable to operate, and can free hands when in use.

[0028] The middle part of the flexible ultrasonic patch of the present invention adopts a hollow design, so that objects can still be seen with the eyes during use.

[0029] The present invention adopts a stretchable serpentine wire, which can achieve precise fitting of the ultrasound module with the surface projection area of ​​the periocular acupoints by stretching and bending the wire according to the differences in individual periocular acupoints, providing a convenient and universal solution for relieving visual fatigue. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 is a schematic structural diagram of the flexible ultrasonic patch of the present invention;

[0031] Figure 2 is a schematic diagram of the flexible ultrasonic patch of the present invention being attached to the periorbital area;

[0032] Figure 3 is a schematic structural diagram of an ultrasound module in a specific embodiment of the present invention;

[0033] Figure 4 It is a schematic diagram of a mold customized for integrally assembling a flexible circuit according to the present invention;

[0034] Figure 5 It is a schematic diagram of a process of using a mold to integrally assemble a flexible ultrasonic patch in a specific embodiment of the present invention.

[0035] Figure 6 is a finite element simulation result diagram of the change of ultrasonic normalized sound pressure with incident tissue depth in a specific embodiment of the present invention;

[0036] Description of reference numerals:

[0037] 1 flexible adhesion layer, 2 flexible packaging layer, 3 ultrasonic module, 31 piezoelectric device, 32 matching layer, 33 positive metal electrode, 34 negative metal electrode, 4 conductive adhesive layer, 5 upper polyimide protective layer, 6 stretchable serpentine wire, 7 lower polyimide protective layer, 8 flexible substrate layer, 9 mold for overall assembly of flexible ultrasonic patch, 91 bottom layer mold, 92 substrate layer mold, 93 packaging layer mold, 94 adhesion layer mold, 95 positioning pin. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below through the accompanying drawings and embodiments. However, it should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the scope of the present invention. In addition, in the following description, the description of known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present invention.

[0039] The present invention provides a flexible ultrasonic patch for "acupuncture" of periocular acupuncture points for relieving visual fatigue. The patch is used for emitting ultrasonic waves to relevant periocular acupuncture points, thereby relieving visual fatigue through acupuncture point stimulation.

[0040] In a specific embodiment of the present invention, Figure 1 As shown, the flexible ultrasonic patch includes, from top to bottom, a flexible adhesive layer 1, a flexible packaging layer 2, an ultrasonic module 3, a positive / negative flexible circuit, and a flexible substrate layer 8; the positive flexible circuit and the negative flexible circuit respectively include an upper polyimide protective layer 5, a stretchable serpentine conductor 6, and a lower polyimide protective layer 7.

[0041] The lower surface of the stretchable serpentine wire 6 is completely wrapped by the lower polyimide protective layer 7, and the upper surface is partially wrapped by the upper polyimide protective layer 5 and exposes the soldering point position, and the soldering point position is used to coat the conductive adhesive layer 4, and the conductive adhesive layer 4 is used to connect the stretchable serpentine wire 6 in the positive flexible circuit and the negative flexible circuit with the positive metal electrode 33 and the negative metal electrode 34; the conductive adhesive layer 4 is conductive silver glue, low-temperature solder paste or conductive composite material.

[0042] The flexible adhesive layer 1 is a medical adhesive, hydrogel or uncured silicone, and is used to achieve a close fit between the flexible ultrasound patch and the skin around the eye; the flexible packaging layer 2 and the flexible substrate layer 8 are PDMS or Eco-flex.

[0043] The positive flexible circuit and the negative flexible circuit are electrically connected to the positive electrode and the negative electrode of the adjustable AC power supply through the wiring. The adjustable AC power supply synchronously excites the ultrasonic module 3 to achieve the effect of relieving visual fatigue by stimulating the corresponding acupuncture points around the eyes.

[0044] like Figure 2 As shown, there are 4 groups of ultrasonic modules 3 with the same natural frequency and connected in parallel; by adjusting the stretchable serpentine wire, the ultrasonic modules 3 are accurately attached to the body surface projections corresponding to the Zuanzu point, the temple, the Jingming point and the Sibai point around the eye.

[0045] like Figure 3As shown, the ultrasonic module 3 is composed of a piezoelectric device 31, a matching layer 32, a positive metal electrode 33, and a negative metal electrode 34; the piezoelectric device 31 is provided with a negative metal electrode 34 on the lower surface, and a positive metal electrode 33 on the upper surface; the positive metal electrode 33 is a flanged electrode, extending to the same side as the negative metal electrode 34, so as to achieve single-sided welding with the positive flexible circuit and the negative flexible circuit; one side of the matching layer 32 is bonded to the flexible packaging layer 2, and the other side is bonded to the positive metal electrode 33.

[0046] The adjustable AC power supply provided in the specific embodiment of the present invention is a portable resonant power supply, which is small in size, light in weight, and easy to carry around, and can simultaneously excite four groups of ultrasonic modules 3 to emit ultrasonic waves of the same frequency and intensity.

[0047] The adjustable AC power supply transmission frequency provided in the specific embodiment of the present invention is 1-3 MHz. Based on the mechanical action and thermal effect of ultrasound, the corresponding acupuncture points are stimulated percutaneously to achieve the effect of nerve regulation.

[0048] The specific embodiment of the present invention also provides a method for preparing a flexible ultrasonic patch for acupuncture of the eye points for relieving visual fatigue, wherein a customized mold 9 for overall assembly of the flexible ultrasonic patch is provided. Figure 4 As shown, the mold 9 used for the overall assembly of the flexible ultrasonic patch includes, from bottom to top, a bottom layer mold 91, a substrate layer mold 92, a packaging layer mold 93, an adhesion layer mold 94, and positioning pins 95 for positioning each layer of the mold.

[0049] The preparation method of the flexible ultrasonic patch comprises the following steps:

[0050] 1) Preparation of flexible circuit: preparing the upper polyimide protective layer 5, the stretchable serpentine conductor 6, and the lower polyimide protective layer 7 by micro-nano processing method;

[0051] a. Metal aluminum is plated on the silicon wafer through an electron beam evaporation system, and the metal aluminum serves as a sacrificial layer.

[0052] b. Spin-coat a polyimide film on the metal aluminum layer, with the curing temperature and time being 120°C for 1 hour, 200°C for 2 hours, and 250°C for 2.5 hours.

[0053] c. Spin-coat photoresist on the cured polyimide film at a curing temperature and time of 100°C for 60 seconds.

[0054] d. Perform the first photolithography on the above silicon wafer, put it into the exposure position of the photolithography machine, and place the mask on top of the silicon wafer. Expose for about 26 seconds, and then take out the mask and silicon wafer.

[0055] e. Place the above silicon wafer in the developer for 60 seconds, rinse with deionized water and dry.

[0056] f. Place the developed silicon wafer into an electron beam evaporation system for electroplating, followed by electroplating chromium and gold.

[0057] g. Place the gold-plated silicon wafer in an acetone solution to remove excess metal, leaving the photolithographic pattern. Rinse with deionized water and dry.

[0058] h. Spin-coat the polyimide solution on the silicon wafer with the circuit, and the curing temperature and time are 120°C for 1 hour, 200°C for 2 hours, and 250°C for 2.5 hours.

[0059] i. After curing, the polyimide film is spin-coated with photoresist at a curing time of 100°C for 60 seconds.

[0060] j. After the photoresist is cured, a second photolithography is performed to expose the electrodes of the welding part. The above silicon wafer is placed in the exposure position of the photolithography machine, and a mask is placed on the silicon wafer. After adjusting the alignment between the silicon wafer and the mask, the exposure source is moved above the mask, and the exposure is performed for about 26 seconds, and the mask and silicon wafer are taken out.

[0061] k. Place the exposed silicon wafer in the developer for 60 seconds. After development, rinse with deionized water and dry.

[0062] 1. Place the developed silicon wafer into an electron beam evaporation system for aluminum coating. The aluminum here is a sacrificial layer to prepare for the plasma etching below.

[0063] m. After the aluminum plating is completed, the polyimide film not covered by aluminum is etched using plasma etching technology.

[0064] n. After etching, put the silicon wafer into a mixed solution of sodium chloride and hydrochloric acid to electrolyze aluminum. After electrolysis, the positive / negative flexible circuit floats in the liquid. Use a laser cutter to cut the water-soluble tape according to the shape of the flexible ultrasonic patch, pick up the positive / negative flexible circuit with tweezers and stick it on the water-soluble tape.

[0065] 2) Overall assembly of the device: The flexible ultrasonic patch is assembled as a whole using the mold 9 for overall assembly of the flexible ultrasonic patch. The assembly process is as follows: Figure 5 As shown:

[0066] a. With the aid of the positioning pins 95, the substrate layer mold 92 is assembled on the bottom mold 91, the precursor of the flexible substrate layer 8 is poured and heated and cured;

[0067] b. Transferring the positive / negative flexible circuit to the flexible substrate layer 8 through a water-soluble tape, coating the conductive adhesive layer 4 at the solder joints of the positive / negative flexible circuit, and welding the wiring at the exposed solder joints at the ends of the positive / negative flexible circuit by a hot pressing process;

[0068] c. connecting the ultrasonic module 3 to the positive / negative flexible circuit through the conductive adhesive layer 4;

[0069] d. Assembling the encapsulation layer mold 93, pouring the precursor of the flexible encapsulation layer 2 and heating and curing it to achieve the overall encapsulation of the flexible ultrasonic circuit;

[0070] e. Assembling the adhesive layer mold 94, pouring the precursor of the flexible adhesive layer 1 and heating and curing;

[0071] 3) releasing the flexible ultrasonic patch and connecting it to an adjustable AC power source via a flat cable.

[0072] In a specific embodiment, this example is used to relieve visual fatigue caused by daily work; the piezoelectric device 31 adopts a planar 1-3 piezoelectric composite material with a side length of 2 mm and a natural frequency of 1 MHz; the conductive adhesive layer 4 adopts a conductive silver glue with a curing temperature of 60°C, and the ultrasonic module 3 is single-sidedly welded to the positive / negative flexible circuit; the flexible packaging layer 2 and the flexible substrate layer 8 are used to complete the packaging of the device, and the flexible packaging layer 2 and the flexible substrate layer 8 are Eco-flex; a flexible adhesion layer 1 is used to achieve conformal attachment of the flexible ultrasonic patch to the skin around the eye, and the flexible adhesion layer 1 is uncured silicone.

[0073] When the eyes feel uncomfortable, attach the flexible ultrasonic patch to the periorbital area, and by stretching and bending the serpentine wire, each ultrasonic module 3 is accurately attached to the corresponding body surface projections of the Cuanzu acupoint, Taiyang acupoint, Jingming acupoint and Sibai acupoint; control the adjustable AC power supply to excite the ultrasonic module 3 to emit low-intensity pulsed ultrasound at a frequency of 1MHz. Figure 6 As shown, the normalized sound pressure at this time is still about 20% of the maximum sound pressure at the incident depth of 40 mm, indicating that the pulsed ultrasound can reach the depth of the target acupuncture point.

[0074] In other embodiments, the piezoelectric device 31 may be a hemispherical arc-shaped focusing piezoelectric ceramic or a compact piezoelectric phased array to stimulate the acupuncture points by means of focused ultrasound.

[0075] It should be understood that the above description of the disclosed embodiments enables professionals and technicians in the field to implement or use the present invention. The above is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, without departing from the principles of the present invention, several improvements and supplements can be made, and these improvements and supplements should also be regarded as the scope of protection of the present invention. Various modifications to these embodiments will be obvious to professionals and technicians in the field, and the general principles defined in the present invention can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown in the present invention, but will conform to the widest range consistent with the principles and novel features disclosed in the present invention.

Claims

1. A flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue, characterized in that: The flexible ultrasonic patch includes, from top to bottom, a flexible adhesion layer, a flexible packaging layer, an ultrasonic module, a positive / negative flexible circuit, and a flexible substrate layer; the positive / negative flexible circuits respectively include an upper polyimide protective layer, a stretchable serpentine wire, and a lower polyimide protective layer; the flexible adhesion layer is used to tightly fit the flexible ultrasonic patch to the skin around the eye; the positive flexible circuit and the negative flexible circuit are respectively electrically connected to the positive electrode and the negative electrode of an adjustable AC power supply; the adjustable AC power supply synchronously excites the ultrasonic module to achieve the effect of relieving visual fatigue by stimulating the corresponding acupuncture points around the eye.

2. A flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue according to claim 1, characterized in that: The ultrasonic module consists of a piezoelectric device, a matching layer, a positive metal electrode, and a negative metal electrode; a negative metal electrode is provided on the lower surface of the piezoelectric device, and a positive metal electrode is provided on the upper surface; the positive metal electrode is a flanged electrode, extending to the same side as the negative metal electrode, thereby realizing single-sided welding with the positive / negative flexible circuit; one side of the matching layer is bonded to the flexible packaging layer, and the other side is bonded to the positive metal electrode.

3. A flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue according to claim 2, characterized in that: The piezoelectric device is a 1-3 type piezoelectric composite material or a piezoelectric ceramic; the matching layer is a composite material formed by doping nano metal powder or nano metal oxide powder into epoxy resin.

4. The flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue according to claim 2, characterized in that: The lower surface of the stretchable serpentine wire is completely wrapped by the lower polyimide protective layer, and the upper surface is partially wrapped by the upper polyimide protective layer and exposes the welding point position; the welding point position is used to coat the conductive adhesive layer, and the conductive adhesive layer is used to realize the connection between the stretchable serpentine wire in the positive flexible circuit and the negative flexible circuit and the positive metal electrode and the negative metal electrode.

5. The flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue according to claim 4, characterized in that: The conductive adhesive layer is conductive silver glue, low-temperature solder paste or conductive composite material.

6. The flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue according to claim 1, characterized in that: There are 4 groups of ultrasonic modules, each having the same natural frequency and connected in parallel, and each attached to the projection of the periocular acupuncture points on the body surface.

7. The flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue according to claim 1, characterized in that: The positive flexible circuit and the negative flexible circuit are electrically connected to the positive electrode and the negative electrode of the adjustable AC power supply through the wiring, and the transmission frequency of the adjustable AC power supply is 1-3 MHz.

8. The flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue according to claim 1, characterized in that: The flexible adhesive layer is medical adhesive, hydrogel or uncured silica gel; the flexible packaging layer and the flexible substrate layer are PDMS or Eco-flex.

9. A flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue according to any one of claims 1 to 8, characterized in that: Its preparation relies on a customized mold for the overall assembly of the flexible ultrasonic patch; the mold includes a bottom mold, a substrate layer mold, a packaging layer mold, an adhesion layer mold, and positioning pins for positioning each layer of the mold from bottom to top; the bottom mold and the packaging layer mold are made of acrylic; the substrate layer mold and the adhesion layer mold are made of stainless steel.

10. The method for preparing a flexible ultrasonic patch for acupuncture of periocular acupuncture points for relieving visual fatigue as claimed in claim 9, characterized in that: The method for preparing the flexible ultrasonic patch comprises the following steps: 1) Preparation of flexible circuits: preparing the upper polyimide protective layer, the stretchable serpentine conductor, and the lower polyimide protective layer by micro-nano processing methods; 2) Overall assembly of the device: Use a customized mold to assemble the flexible ultrasound patch: a. With the assistance of positioning pins, assemble the substrate layer mold on the bottom mold, pour the precursor of the flexible substrate layer and heat and cure; b. transferring the positive / negative flexible circuit to the flexible substrate layer, coating the conductive adhesive layer at the solder joints of the positive / negative flexible circuit, and welding the wiring at the exposed solder joints at the ends of the positive / negative flexible circuit by a hot pressing process; c. connecting the ultrasonic module to the positive / negative flexible circuit through the conductive adhesive layer; d. Assemble the encapsulation layer mold, pour the precursor of the flexible encapsulation layer and heat and cure it to achieve the overall encapsulation of the flexible ultrasonic circuit; e. Assembling the adhesive layer mold, pouring the precursor of the flexible adhesive layer and heating and curing; 3) releasing the flexible ultrasonic patch and connecting it to an adjustable AC power source via a flat cable.

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