Adjustable support method for incubation trays in an integrated incubation and wash module

Abstract

The application discloses a kind of adjustable support methods of incubation disc in integrated incubation cleaning module, the incubation disc is annular, and cleaning disc is located at the inner circumferential side position of annular incubation disc;The adjustable support method is to design the connecting point of annular incubation disc as at least two position fixed connecting points and at least one position adjustable connecting point, when cleaning disc is installed, the position of the at least one position adjustable connecting point is adjusted, the installation position of incubation disc is adjusted, so that incubation disc support is connected in the outer circumferential side position of cleaning disc.The application sets one of the three connecting points as position adjustable connecting point, and the position of annular incubation disc is determined by the three connecting points after adjustment, so as to ensure that after the installation of incubation disc in integrated incubation cleaning module is completed, it can adapt to the action of internal transport mechanism of reaction cup.

Description

TECHNICAL FIELD

[0001] The application relates to a mounting method of an incubation disc in an integrated incubation and cleaning module, in particular to an adjustable supporting method of an incubation disc of an integrated incubation and cleaning module in a full-automatic single-molecule immune analysis device, and belongs to the technical field of medical examination. BACKGROUND

[0002] Since the first automatic chemical analysis instrument was manufactured, more than half a century has passed, and full-automatic immune analysis instruments have been mature in technology. The full-automatic immune analysis instruments have the following characteristics: 1, a multi-degree-of-freedom mechanical arm is adopted to coordinate the actions between modules; 2, the instrument has strong flexibility and can meet various analysis requirements; 3, the test speed is high, and the instrument can continuously run for a long time without human intervention; 4, various technologies are combined in the detection technology, and complete automation is realized in processing, so that the detection result is more accurate and the precision is higher. The full-automatic immune analysis instrument can realize the steps of taking a reaction cup, adding a sample, adding a reaction liquid, shaking, promoting a reaction, measuring, operation and analysis, cleaning and the like in the experimental test process, and the instrument replaces manual operation, not only saving the labor cost, but more importantly, eliminating human errors and ensuring the accuracy of data. The full-automatic immune analysis instrument has the advantages of rapidness, high efficiency, high precision and consistent repeatability, and is widely applied in the fields of processing, production, testing and life assistance, and will inevitably become a trend in the medical detection field.

[0003] In the previous technology, the main process of the incubation and cleaning device in the immune analysis instrument is that the reaction cup added with a sample and a reagent is placed in an independent incubation module to be heated and incubated, and then the reaction cup is taken out by a mechanical hand and placed in another cleaning module to be magnetically separated and cleaned. Since the incubation and the cleaning are two completely independent modules, the overall volume of the immune analysis device is large, the structure is complex, and the cost is also high. Therefore, in the prior art, the incubation disc responsible for incubation and the cleaning disc responsible for cleaning are coaxially arranged and integrated into an incubation and cleaning module. In this way, the overall volume of the immune analysis device is reduced compared with the previous one.

[0004] During the working process, the position of the reaction cup needs to be exchanged between the cleaning disc and the incubation disc, and in the integrated incubation and cleaning module, the prior art adopts an external mechanical hand to perform the external transfer, that is, the external mechanical hand is used to take out the reaction cup on the cleaning disc and place the reaction cup into the incubation disc or take out the reaction cup on the incubation disc and place the reaction cup into the cleaning disc. However, since the prior art adopts the mechanical hand arranged outside the incubation and cleaning module to perform the external transfer, the overall volume of the immune analysis device is still large to some extent.

[0005] The relevant patent documents searched are as follows:

[0006] I. The Chinese utility model patent with the publication number CN207636603U and the publication date of July 20, 2018 discloses an incubation and cleaning device, which comprises an incubation disc, a cleaning disc, a driving assembly and a heating assembly. The incubation disc comprises an incubation disc body for incubating samples in reaction cups. The cleaning disc is coaxial with the incubation disc and arranged in concentric circles. The cleaning disc is used for multi-stage cleaning of magnetic microparticles in the reaction cups. The driving assembly is a coaxial driving structure comprising two driving motors for driving the incubation disc and the cleaning disc to move independently. The heating assembly is located below the incubation disc and the cleaning disc for heating the incubation disc and the cleaning disc.

[0007] In the above patent document, the cleaning disc and the incubation disc are coaxial and arranged in concentric circles, which are integrated together. The document does not disclose how the reaction cups are transported between the integrated cleaning disc and the incubation disc, but from the drawings, it should also be transported by a mechanical hand from the outside.

[0008] II. The Chinese utility model patent with the publication number CN217688992U and the publication date of October 28, 2022 discloses a sample analysis device, which comprises: a reaction container supply unit for providing unused reaction containers; a dispensing unit for injecting reagents or / and samples into the reaction containers; an incubation disc unit for incubating the liquid in the reaction containers; a cleaning disc unit for removing unbound components in the reaction system in the reaction containers; a detection unit for detecting the analyte in the reaction containers; the cleaning disc unit is coaxially arranged outside or inside the incubation disc unit, and the cleaning disc unit and the incubation disc unit operate independently; a reaction container transport mechanism for transporting the reaction containers between the reaction container supply unit, the incubation disc unit and the cleaning disc unit; the reaction container supply unit has a reaction container supply unit cup grabbing position, the incubation disc unit has an incubation disc cup grabbing position, and the cleaning disc unit has a cleaning disc cup grabbing position, and the reaction container supply unit cup grabbing position, the incubation disc cup grabbing position and the cleaning disc cup grabbing position are located on the movement track of the reaction container transport unit.

[0009] In this patent document, the incubation disc unit and the cleaning disc unit are coaxially arranged and integrated together. However, it also uses a gripper arranged outside to transport the reaction cups between the incubation disc unit and the cleaning disc unit.

[0010] Therefore, the applicant designs a reaction cup internal transfer mechanism, which moves along the incubation disc and the cleaning disc in the radial direction to transfer the reaction cup between the incubation disc and the cleaning disc, thereby avoiding external transfer as much as possible and reducing the setting of external related components.

[0011] Therefore, the installation method of the incubation disc in the integrated incubation and cleaning module needs to be improved to adapt to the action of the reaction cup internal transfer mechanism, otherwise the internal transfer operation of the reaction cup cannot be completed. SUMMARY

[0012] The technical problem to be solved by the present application is to provide an adjustable support method for an incubation disc in an integrated incubation and cleaning module, which can adapt to the action of a reaction cup internal transfer mechanism after the installation of the incubation disc is completed, thereby realizing the internal transfer operation of the reaction cup, changing the existing mode of external transfer of the reaction cup, reducing the setting of external related components, reducing the overall volume of the immunoassay device, simplifying the overall structure of the immunoassay device, and reducing the overall cost of the immunoassay device.

[0013] To solve the above technical problems, the technical solution adopted by the present application is as follows: an adjustable support method for an incubation disc in an integrated incubation and cleaning module, the incubation disc is annular, and a cleaning disc is located at the inner circumferential side of the annular incubation disc; the adjustable support method is to design at least two position-fixed connection points and at least one position-adjustable connection point for the connection of the annular incubation disc, and after the cleaning disc is installed, the position of the at least one position-adjustable connection point is adjusted to adjust the installation position of the incubation disc, so that the incubation disc is supported and connected at the outer circumferential side of the cleaning disc.

[0014] Preferably, the position-fixed connection point is provided as a position-fixed horizontal guide wheel structure, and the position-adjustable connection point is provided as a position-adjustable horizontal guide wheel structure, and the incubation disc is supported and connected at the outer circumferential side of the cleaning disc by using the position-fixed horizontal guide wheel structure and the position-adjustable horizontal guide wheel structure.

[0015] Preferably, the fixed position horizontal guide wheel structure comprises a support column one and a horizontal guide wheel one arranged on the top of the support column one, a guide slot is arranged on the circumferential surface of the horizontal guide wheel one, the adjustable position horizontal guide wheel structure comprises a support column two and a support column three, a swing arm is hingedly connected to the top of the support column two, one end of the swing arm is hingedly connected to the top of the support column two, a swing arm waist hole is arranged on the other end of the swing arm, a screw one is screwed into the top of the support column three through the swing arm waist hole, so as to lock the other end of the swing arm on the top of the support column three, a horizontal guide wheel two is arranged on the swing arm, and a guide slot is also arranged on the circumferential surface of the horizontal guide wheel two.

[0016] The specific steps of the adjustable support method are as follows: the inner circumferential part of the incubation disc is clamped into the guide slot of the horizontal guide wheel one of the at least two fixed position horizontal guide wheel structures and the guide slot of the horizontal guide wheel two of the at least one adjustable position horizontal guide wheel structure, the position of the swing arm of the at least one adjustable position horizontal guide wheel structure is adjusted, so that one U-shaped groove two on the incubation disc and one U-shaped groove one on the cleaning disc can be in the same radial line B, then the screw one is locked to lock the swing arm, so as to support and connect the incubation disc on the outer circumferential side of the cleaning disc.

[0017] Preferably, a reaction cup internal transfer mechanism is arranged in the integrated incubation and cleaning module, and the reaction cup is transferred between the cleaning disc and the incubation disc by the reaction cup internal transfer mechanism.

[0018] Preferably, the U-shaped groove one is used for supporting the reaction cup, a plurality of U-shaped grooves one are arranged on the cleaning disc, the U-shaped groove one is arranged in the radial direction of the cleaning disc, the U-shaped groove two is also used for supporting the reaction cup, a plurality of U-shaped grooves two are arranged on the incubation disc, the U-shaped groove two is arranged in the radial direction of the incubation disc, when the cleaning disc and the incubation disc are assembled, the groove opening of the U-shaped groove one and the groove opening of the U-shaped groove two are arranged opposite to each other, and through the rotation of the cleaning disc and the incubation disc, one U-shaped groove one and one U-shaped groove two can be in the same radial line.

[0019] During the transfer, the reaction cup is moved from the U-shaped groove one to the U-shaped groove two or from the U-shaped groove two to the U-shaped groove one in the radial direction of the cleaning disc and the incubation disc by the reaction cup internal transfer mechanism, so as to transfer the reaction cup between the cleaning disc and the incubation disc.

[0020] Preferably, the reaction cup internal transfer mechanism comprises an X-axis moving device and a Z-axis moving device arranged on the X-axis moving device, and a transfer cylinder is arranged on the Z-axis moving device, the X-axis moving device and the Z-axis moving device constitute a two-dimensional moving mechanism, the X-axis is arranged along the radial direction of the cleaning disc and the incubation disc, the Z-axis is perpendicular to the direction of the X-axis, through the action of the two-dimensional moving mechanism, the transfer cylinder is driven to move in two-dimensional direction, and finally the reaction cup is transferred between the cleaning disc and the incubation disc by the transfer cylinder.

[0021] Preferably, when the reaction cup is transferred from the incubation disc to the cleaning disc, first, the incubation disc and the cleaning disc are controlled to rotate, so that the notch of one U-shaped groove two on the incubation disc and the notch of one U-shaped groove one on the cleaning disc are aligned along the radial direction of the incubation disc and the cleaning disc, and then the specific operation steps are as follows:

[0022] 1) Control the Y-axis moving device to move upward, so that the transfer cylinder is in contact with the reaction cup located in the U-shaped groove two and the reaction cup is lifted from the U-shaped groove two during the continuous upward movement of the transfer cylinder;

[0023] 2) Control the X-axis moving device to move along the radial direction towards the cleaning disc, so that the reaction cup is moved out of the notch of the U-shaped groove two and then moved into the notch of the U-shaped groove one, and finally moved to a position above the groove bottom of the U-shaped groove one;

[0024] 3) Control the Y-axis moving device to move downward, so that the reaction cup is placed into the U-shaped groove one of the cleaning disc; when the transfer cylinder is moved to the position, the transfer cylinder is separated from the reaction cup.

[0025] Preferably, when the reaction cup is transferred from the cleaning disc to the incubation disc, first, the incubation disc and the cleaning disc are controlled to rotate, so that the notch of one U-shaped groove two on the incubation disc and the notch of one U-shaped groove one on the cleaning disc are aligned along the radial direction of the incubation disc and the cleaning disc, and then the specific operation steps are as follows:

[0026] S1, control the Y-axis moving device to move upward, so that the transfer cylinder is in contact with the reaction cup located in the U-shaped groove one and the reaction cup is lifted from the U-shaped groove one during the continuous upward movement of the transfer cylinder;

[0027] S2, control the X-axis moving device to move along the radial direction towards the incubation disc, so that the reaction cup is moved out of the notch of the U-shaped groove one and then moved into the notch of the U-shaped groove two, and finally moved to a position above the groove bottom of the U-shaped groove two;

[0028] S3, control the Y-axis moving device to move downward, so that the reaction cup is placed into the U-shaped groove two of the incubation disc; when the transfer cylinder is moved to the position, the transfer cylinder is separated from the reaction cup.

[0029] The beneficial effect of the present application is that: the present application sets one of the three connection points as a position-adjustable connection point, and determines the position of the annular incubation disc through the adjusted three connection points, so that after the installation of the incubation disc in the integrated incubation and cleaning module is completed, the internal transfer mechanism of the reaction cup can be adapted, the internal transfer operation of the reaction cup is realized, the existing mode of transferring the reaction cup from the outside is changed, the setting of the external related components is reduced, the overall volume of the immune analysis device is reduced, the overall structure of the immune analysis device is simplified, and the overall cost of the immune analysis device is reduced. BRIEF DESCRIPTION OF DRAWINGS

[0030] Figure 1 It is a schematic diagram of the three-dimensional structure of the integrated incubation and cleaning module in the embodiment of the present application;

[0031] Figure 2 It is a schematic diagram of the axial cross-sectional three-dimensional structure of the integrated incubation and cleaning module in the embodiment of the present application;

[0032] Figure 3 It is a schematic diagram of the three-dimensional structure of the cleaning disc in the embodiment of the present application;

[0033] Figure 4 It is a schematic diagram of the three-dimensional structure of the incubation disc in the embodiment of the present application; Figure 3 It is a schematic diagram of the three-dimensional structure of the incubation disc in the embodiment of the present application;

[0034] Figure 5 It is a schematic diagram of the three-dimensional structure of the incubation disc in the embodiment of the present application;

[0035] Figure 6 It is a schematic diagram of the three-dimensional structure of the integrated incubation and cleaning module in the embodiment of the present application after removing the cleaning disc;

[0036] Figure 7 It is a schematic diagram of the three-dimensional structure of the incubation disc in the embodiment of the present application; Figure 6 It is a schematic diagram of the three-dimensional structure of the incubation disc in the embodiment of the present application;

[0037] Figure 8 It is a schematic diagram of the three-dimensional structure of the internal transfer mechanism of the reaction cup in the embodiment of the present application;

[0038] Figure 9 It is a schematic diagram of the three-dimensional structure of the internal transfer mechanism of the reaction cup in the embodiment of the present application;

[0039] Figure 10 It is a schematic diagram of the three-dimensional structure of the incubation disc in the embodiment of the present application;

[0040] Figure 11 It is a schematic diagram of the three-dimensional structure of the incubation disc in the embodiment of the present application; Figure 6 It is a schematic diagram of the three-dimensional structure of the incubation disc in the embodiment of the present application;

[0041] Figure 12 The schematic diagram of the principle structure of the reaction cup internal transfer method in the embodiment of the present application Figure 1 ;

[0042] Figure 13 The schematic diagram of the principle structure of the reaction cup internal transfer method in the embodiment of the present application Figure 2 ;

[0043] Figure 14 The schematic diagram of the principle structure of the reaction cup internal transfer method in the embodiment of the present application Figure 3 ;

[0044] Figure 15 The schematic diagram of the principle structure of the reaction cup internal transfer method in the embodiment of the present application Figure 4 ;

[0045] Figure 16 The schematic diagram of the principle structure of the reaction cup internal transfer method in the embodiment of the present application Figure 5 ;

[0046] Figure 17 The schematic diagram of the principle structure of the reaction cup internal transfer method in the embodiment of the present application

[0047] In the figure: 1. outer shell, 2. foot, 3. cleaning tray, 311. upper tray body, 312. lower tray body, 313. U-shaped groove one, 3131. step one, 4. incubation tray, 411. upper ring body, 4111. outer teeth, 412. lower ring body, 413. U-shaped groove two, 4131. step two, 414. ring body through hole, 5. driving mechanism one, 6. driving mechanism two, 611. transmission gear, 7. reaction cup, 711. reaction cup body, 712. flange, 811. support column one, 812. support column two, 813. support column three, 814. swing arm, 815. swing arm waist hole, 816. horizontal guide wheel two, 9. horizontal guide wheel one, 911. guide groove, 10. reaction cup internal transfer mechanism, 101. connecting seat, 11. transfer cylinder, 12. stepper motor one, 13. lead screw one, 14. nut seat one, 15. stepper motor two, 16. lead screw two, 17. nut seat two. DETAILED DESCRIPTION

[0048] The technical solutions of the present application will be further described in detail below in combination with the drawings and specific embodiments. EMBODIMENT

[0049] The present application first describes the structure of the integrated incubation and cleaning module.

[0050] As Figure 1 and Figure 2As shown in the figure, an integrated incubation and cleaning module comprises a circular outer housing 1, a plurality of supporting legs 2 are arranged at the bottom of the outer housing 1 for facilitating the support of the whole module; a cleaning disc 3 and an incubation disc 4 are rotatably arranged inside the outer housing 1, the incubation disc 4 is arranged in a ring shape, the cleaning disc 3 is located inside the ring-shaped incubation disc 4, and the cleaning disc 3 and the incubation disc 4 are arranged on the same central axis; a driving mechanism one 5 and a driving mechanism two 6, the driving mechanism one 5 is a cleaning disc driving motor, which is arranged on the inner bottom surface of the outer housing 1, and the output shaft of the driving mechanism one 5 is connected with the cleaning disc 3 for driving the rotation of the cleaning disc 3, the driving mechanism two 6 is an incubation disc driving motor, which is arranged on the outer housing 1, and a transmission gear 611 is arranged on the output shaft of the driving mechanism two 6, the transmission gear 611 is in gear transmission connection with the incubation disc 4 for driving the rotation of the incubation disc 4, and the specific gear transmission structure will be described later.

[0051] The structure of the cleaning disc 3 will be described as follows: Figure 3 As shown in the figure, the cleaning disc 3 comprises an upper disc body 311 and a lower disc body 312, the upper disc body 311 is connected with the lower disc body 312 into an integrated body through connecting members such as screws. The output shaft of the cleaning disc driving motor is connected with the central position of the lower disc body 312, so that the cleaning disc 3 can be driven to rotate under the driving of the cleaning disc driving motor. A plurality of U-shaped grooves one 313 for supporting reaction cups are arranged on the lower disc body 312 along the circumferential direction of the cleaning disc, and the U-shaped grooves one 313 are arranged in the radial direction of the lower disc body 312. Figure 4 As shown in the figure, the reaction cup 7 comprises a reaction cup body 711 and a flange 712 arranged on the reaction cup body 711, and the flange 712 is close to the opening position of the reaction cup body 711. When the reaction cup 7 is placed into the U-shaped groove one 313, the flange 712 of the reaction cup 7 is placed on the groove bottom of the U-shaped groove one 313, so as to support the reaction cup. In this embodiment, the groove bottom of the U-shaped groove one 313 is an arc-shaped groove bottom, and a step portion one 3131 is arranged on the lower disc body 312 and located at the groove bottom of the U-shaped groove one 313, and the curvature of the step portion one 3131 matches the curvature of the flange 712 of the reaction cup 7. When the reaction cup 7 is placed into the U-shaped groove one 313, the flange 712 of the reaction cup 7 is placed on the step portion one 3131 of the groove bottom of the U-shaped groove one 313, so as to support the reaction cup. The step portion one 3131 can limit the flange 712 of the reaction cup 7, so as to position the position of the reaction cup 7 on the cleaning disc.

[0052] The structure of the incubation disc 4 will be described as follows: Figures 5 to 7 As shown in the figure, the incubation disc 4 comprises an upper ring body 411 and a lower ring body 412, and the upper ring body 411 is connected with the lower ring body 412 into an integrated body through connecting members such as screws.

[0053] The outer periphery of the upper ring body 411 is provided with outer teeth 4111, which are arranged in a whole circle along the circumference of the upper ring body 411. The transmission gear 611 on the output shaft of the second driving mechanism 6 is in meshing transmission connection with the outer teeth 4111 of the upper ring body 411, so that the incubation tray 4 can be driven to rotate by the second driving mechanism.

[0054] The structure of the incubation tray for supporting the reaction cups is the same as that of the washing tray for supporting the reaction cups. As shown in Figure 5 and Figure 7 A plurality of U-shaped grooves two 413 for supporting the reaction cups are arranged on the lower ring body 412 of the incubation tray along the circumference of the incubation tray. The U-shaped grooves two 413 are arranged along the radial direction of the lower ring body 412. When the incubation tray and the washing tray are assembled, the openings of the U-shaped grooves two 413 and the openings of the U-shaped grooves one 313 are arranged opposite to each other, that is, the direction of the openings of the U-shaped grooves two 413 is opposite to the direction of the openings of the U-shaped grooves one 313, and through the rotation of the incubation tray and the washing tray, one of the U-shaped grooves two 413 and one of the U-shaped grooves one 313 can be arranged on the same radial line.

[0055] When the reaction cup 7 is placed into the U-shaped groove two 413, the flange 712 of the reaction cup 7 is placed on the groove bottom of the U-shaped groove two 413, so as to support the reaction cup. In the embodiment, the groove bottom of the U-shaped groove two 413 is an arc-shaped groove bottom, and a step portion two 4131 is arranged on the lower ring body 412 and located at the groove bottom of the U-shaped groove two 413. The arc of the step portion two 4131 matches the arc of the flange 712 of the reaction cup 7. When the reaction cup 7 is placed into the U-shaped groove two 413, the flange 712 of the reaction cup 7 is placed on the step portion two 4131 of the groove bottom of the U-shaped groove two 413, so as to support the reaction cup. Through the arrangement of the step portion two 4131, the flange 712 of the reaction cup 7 can be limited, so as to position the position of the reaction cup 7 on the incubation tray.

[0056] In addition, it should be noted that, before incubation and washing, in order to place the reaction cup into the integrated incubation and washing module, a ring body through hole 414 is arranged on the upper ring body 411 and located at the position corresponding to each U-shaped groove two 413. Before incubation and washing, the reaction cup is placed into the U-shaped groove two 413 through the ring body through hole 414, so as to place the reaction cup into the incubation tray, and make the reaction cup enter the integrated incubation and washing module.

[0057] As shown in Figure 6 The integrated incubation and washing module in the embodiment further comprises a reaction cup internal transfer mechanism 10 arranged at the bottom of the outer shell 1. The reaction cup internal transfer mechanism 10 is used for transferring the reaction cup between the washing tray 3 and the incubation tray 4. Figure 8As shown, the reaction cup internal transfer mechanism 10 comprises a connecting seat 101 connected to the bottom of the outer shell 1, an X-axis moving device arranged on the connecting seat 101, and a Z-axis moving device arranged on the X-axis moving device, wherein a transfer cylinder 11 is arranged on the Z-axis moving device, the X-axis moving device and the Z-axis moving device constitute a two-dimensional moving mechanism, the X-axis is arranged along the radial direction of the cleaning disc 3 and the incubation disc 4, and the Z-axis is perpendicular to the direction of the X-axis. Through the action of the two-dimensional moving mechanism, the transfer cylinder 11 is driven to move in two-dimensional direction, and finally the reaction cup is transferred between the cleaning disc 3 and the incubation disc 4 by the transfer cylinder 11. In this embodiment, the X-axis moving device comprises a stepping motor one 12 arranged on the connecting seat 101 and a lead screw one 13 rotatably connected to the connecting seat 101 through a bearing, the output shaft of the stepping motor one 12 is drivingly connected with the lead screw one 13, and a nut seat one 14 is also slidingly connected to the connecting seat 101, the nut seat one 14 is connected with the lead screw one 13 to form a lead screw nut mechanism one, so that the nut seat one 14 can move along the X-axis direction under the action of the stepping motor one 12. The Y-axis moving device comprises a stepping motor two 15 arranged on the nut seat one 14 and a lead screw two 16 rotatably connected to the nut seat one 14 through a bearing, the output shaft of the stepping motor two 15 is drivingly connected with the lead screw two 16, and a nut seat two 17 is also slidingly connected to the nut seat one 14, the nut seat two 17 is connected with the lead screw two 16 to form a lead screw nut mechanism two, so that the nut seat two 17 can move up and down along the Y-axis direction under the action of the stepping motor two 15. The transfer cylinder 11 is connected to the nut seat two 17. It should be noted that the X-axis moving device and the Y-axis moving device can also adopt other structures as long as they can realize two-dimensional direction movement in the X-axis direction and the Y-axis direction.

[0058] As Figure 9 shown, the transfer method adopted in this embodiment is that the transfer cylinder 11 of the reaction cup internal transfer mechanism 10 drives the reaction cup 7 to move along the radial direction of the cleaning disc 3 and the incubation disc 4 (i.e. the X-axis direction) from the U-shaped groove one 313 on the cleaning disc 3 to the U-shaped groove two 413 on the incubation disc 4 or from the U-shaped groove two 413 on the incubation disc 4 to the U-shaped groove one 313 on the cleaning disc 3, so as to realize the transfer work of the reaction cup between the cleaning disc 3 and the incubation disc 4.

[0059] From Figure 9As can be seen, in order to adapt to the action of the reaction cup internal transfer mechanism, the reaction cup internal transfer mechanism moves along the radial direction (i.e. the X-axis direction) of the washing disc 3 and the incubation disc 4. Therefore, it is required to ensure that, after the incubation disc 4 is installed, one of the U-shaped grooves two 413 on the incubation disc 4 and one of the U-shaped grooves one 313 on the washing disc 3 can be located on the same radial line B through the rotation of the incubation disc and the washing disc, so as to ensure that the reaction cup internal transfer mechanism drives the reaction cup 7 to move back and forth between the U-shaped groove one 313 on the washing disc 3 and the U-shaped groove two 413 on the incubation disc 4, and complete the transfer work. However, in reality, after the intermediate washing disc 3 is installed, due to other reasons such as manufacturing and processing of the incubation disc 4, the position of the installed incubation disc 4 cannot meet the above requirements, and therefore needs to be adjusted.

[0060] As shown in Figure 6 and Figure 7 , the incubation disc 4 in the embodiment is arranged in a ring shape and is supported and connected to the inner bottom of the outer housing 1 by three or more horizontal guide wheels 9. Therefore, as shown in Figure 9 and Figure 10 , the ring-shaped incubation disc 4 can actually be regarded as a circle, and each horizontal guide wheel 9 can be regarded as a point C. Since three points C can determine the position of a circle, in order to adjust the position of the incubation disc 4, the applicant designs at least two horizontal guide wheels 9 in the incubation disc 4 as fixed-position horizontal guide wheel structures (i.e. points C1) to keep their positions unchanged, and at least one horizontal guide wheel 9 as a position-adjustable horizontal guide wheel structure (i.e. point C2). After the washing disc 3 is installed, the position of the ring-shaped incubation disc 4 is adjusted by adjusting the position of the position-adjustable horizontal guide wheel structure (i.e. point C2), so as to ensure that, during the work process, through the rotation of the incubation disc and the washing disc, one of the U-shaped grooves two 413 on the incubation disc 4 and one of the U-shaped grooves one 313 on the washing disc 3 can be located on the same radial line B, so as to adapt to the action of the reaction cup internal transfer mechanism. Therefore, in the embodiment, there is at least one position-adjustable horizontal guide wheel structure (i.e. point C2) and at least two fixed-position horizontal guide wheel structures (i.e. points C1).

[0061] As shown in Figure 7 , the fixed-position horizontal guide wheel structure includes a support column one 811 arranged on the inner bottom of the outer housing 1 and a horizontal guide wheel one 9 arranged on the top of the support column one 811. A guide groove 911 is opened on the peripheral surface of the horizontal guide wheel one 9, and the guide groove 911 is arranged in a whole circle along the peripheral direction of the horizontal guide wheel one 9. The inner peripheral part of the upper ring body 411 is clamped into the guide groove 911 of the horizontal guide wheel one 9 to be in transmission connection with the guide groove 911, so that the incubation disc 4 is arranged to rotate in the inner part of the outer housing 1.

[0062] As shown in Figure 11 , the position-adjustable horizontal guide wheel structure includes support column two 812 and support column three 813 arranged on the inner bottom of the outer shell 1, a swing arm 814 is hinged on the top of the support column two 812, one end of the swing arm 814 is hinged on the top of the support column two 812, a swing arm waist hole 815 is opened on the other end of the swing arm 814, a screw one (not shown in the figure) is screwed into the top of the support column three 813 through the swing arm waist hole 815, so as to lock the other end of the swing arm 814 on the top of the support column three 813, and a horizontal guide wheel two 816 is arranged on the swing arm 814. A guide groove is also opened on the peripheral surface of the horizontal guide wheel two 816, and the guide groove is arranged in a whole circle along the circumference of the horizontal guide wheel two 816. By clamping the inner circumferential part of the upper ring body 411 into the guide groove of the horizontal guide wheel two 816 and cooperating with the guide groove, the incubation tray 4 is arranged to rotate inside the outer shell 1.

[0063] The specific steps of the adjustable support method of the incubation tray in this embodiment are as follows: as shown in Figure 7 and Figure 11 , the inner circumferential part of the upper ring body 411 of the incubation tray is clamped into the guide groove 911 of the horizontal guide wheel one 9 of the at least two position-fixed horizontal guide wheel structures and the guide groove of the at least one position-adjustable horizontal guide wheel structure, and then the position of the swing arm 814 of the at least one position-adjustable horizontal guide wheel structure is adjusted, so that one of the U-shaped grooves two 413 on the incubation tray 4 and one of the U-shaped grooves one 313 on the cleaning tray 3 can be in the same radial line B, and then the screw one is locked to lock the swing arm 814, so that the incubation tray 4 is arranged to rotate inside the outer shell 1.

[0064] In this embodiment, one of the three connection points is set as a position-adjustable connection point, and the position of the ring-shaped incubation tray is determined by the three adjusted connection points, so that after the installation of the incubation tray in the integrated incubation and cleaning module is completed, the internal transfer mechanism of the reaction cup can be adapted, the internal transfer operation of the reaction cup is realized, the existing mode of transferring the reaction cup from the outside is changed, the setting of the external related components is reduced, the overall volume of the immune analysis device is reduced, the overall structure of the immune analysis device is simplified, and the overall cost of the immune analysis device is reduced.

[0065] The specific transfer operation of the internal transfer mechanism of the reaction cup is described below:

[0066] As shown in Figure 9As shown, when the reaction cup is transferred from the incubation tray 4 to the washing tray 3, first, the incubation tray 4 and the washing tray 3 are controlled to rotate so that the notch of one U-shaped groove two 413 on the incubation tray 4 and the notch of one U-shaped groove one 313 on the washing tray 3 are aligned along the radial direction of the incubation tray 4 and the washing tray 3, and then the specific operation steps are as follows:

[0067] 1), as shown in Figure 12 and Figure 13 , the Y-axis moving device is controlled to act so that the transfer cylinder 11 moves upward, so that the transfer cylinder 11 contacts the reaction cup 7 located in the U-shaped groove two 413 and in the process of continuous upward movement of the transfer cylinder 11, the reaction cup 7 is lifted from the U-shaped groove two 413, so that the flange 712 of the reaction cup leaves a vertical distance H1 from the notch plane of the U-shaped groove two 413, to avoid the reaction cup being hindered when moving radially;

[0068] 2), as shown in Figure 14 and Figure 15 , the X-axis moving device is controlled to act so that the transfer cylinder 11 moves along the radial direction towards the washing tray 3, driving the reaction cup 7 to move out of the notch of the U-shaped groove two 413 and then into the notch of the U-shaped groove one 313, until it moves to a position above the bottom of the notch of the U-shaped groove one 313, at this time, the flange 712 of the reaction cup leaves a vertical distance H2 from the notch plane of the U-shaped groove one 313;

[0069] 3), as shown in Figure 16 , the Y-axis moving device is controlled to act so that the transfer cylinder 11 moves downward, so that the flange 712 of the reaction cup is placed into the U-shaped groove one 313, thereby placing the reaction cup 7 into the washing tray 3; when the transfer cylinder 11 is moved to the position, the transfer cylinder 11 is separated from the reaction cup 7, so that it does not hinder the rotation of the tray body in the subsequent detection process.

[0070] Conversely, when the reaction cup is transferred from the washing tray 3 to the incubation tray 4, the specific operation steps are just the opposite of the above, that is:

[0071] First, the incubation tray 4 and the washing tray 3 are controlled to rotate so that the notch of one U-shaped groove two 413 on the incubation tray 4 and the notch of one U-shaped groove one 313 on the washing tray 3 are aligned along the radial direction of the incubation tray 4 and the washing tray 3, and then the specific operation steps are as follows:

[0072] S1, the Y-axis moving device is controlled to act so that the transfer cylinder 11 moves upward, so that the transfer cylinder 11 contacts the reaction cup 7 located in the U-shaped groove one 313 and in the process of continuous upward movement of the transfer cylinder 11, the reaction cup 7 is lifted from the U-shaped groove one 313, so that the flange 712 of the reaction cup leaves a vertical distance H2 from the notch plane of the U-shaped groove one 313, to avoid the reaction cup being hindered when moving radially;

[0073] S2, control the X-axis moving device to move so that the transfer cylinder 11 moves along the radial direction towards the incubation tray 4, drives the reaction cup 7 to move out of the slot of the U-shaped groove one 313, and then moves into the slot of the U-shaped groove two 413, until it moves to the position above the bottom of the U-shaped groove two 413, at this time, the flange 712 of the reaction cup leaves a vertical distance H1 with the slot plane of the U-shaped groove two 413;

[0074] S3, control the Y-axis moving device to move so that the transfer cylinder 11 moves downwards, so that the flange 712 of the reaction cup is placed into the U-shaped groove two 413, thereby putting the reaction cup 7 into the incubation tray 4; when the transfer cylinder 11 is moved to the position, the transfer cylinder 11 is separated from the reaction cup 7, so as to ensure that it does not hinder the rotation of the tray body in the subsequent detection process.

[0075] Through the above specific operation steps, the transfer operation of the reaction cup in the integrated incubation and cleaning module is realized without the help of an external mechanical hand. Under the premise of ensuring the normal transfer of the reaction cup, the existing mode of transferring the reaction cup from the outside is changed, the setting of the external related components is reduced, thereby reducing the overall volume of the immune analysis device, simplifying the overall structure of the immune analysis device, and reducing the overall cost of the immune analysis device.

[0076] As shown in Figure 4 and Figure 17 , the cup body 711 of the reaction cup is a conical cylinder, the large end is located at the upper position (i.e. close to the flange 712 side), and the lower end is located at the lower position (i.e. away from the flange 712 side, correspondingly, the transfer cylinder inner cavity 111 of the transfer cylinder 11 is also designed as a conical shape with a large upper and a small lower, as shown in Figure 12 When the reaction cup is lifted by the transfer cylinder 11, the taper surface of the transfer cylinder inner cavity 111 is matched and contacted with the taper surface of the cup body 711 of the reaction cup, thereby lifting the reaction cup. When the taper of the taper surface of the transfer cylinder inner cavity 111 is designed to be different from the taper of the taper surface of the cup body 711 of the reaction cup, the position where the taper surface of the transfer cylinder inner cavity 111 is matched and contacted with the taper surface of the cup body 711 of the reaction cup is set as the contact part S, and the position of the contact part S is adjusted up and down by adjusting the taper of the taper surface of the transfer cylinder inner cavity 111 and the taper of the taper surface of the cup body 711 of the reaction cup. In this way, when the position of the contact part S is different, the stroke and other parameters of the upward movement of the transfer cylinder will actually be different, thereby adapting to various working conditions.

[0077] In conclusion, by setting one of the three connection points as an adjustable position connection point, the position of the ring-shaped incubation disc is determined by the three adjusted connection points, so that after the installation of the incubation disc in the integrated incubation and cleaning module is completed, the internal transfer mechanism of the reaction cup can be adapted, the internal transfer operation of the reaction cup is realized, the existing mode of transferring the reaction cup from the outside is changed, the setting of the external related components is reduced, the overall volume of the immune analysis device is reduced, the overall structure of the immune analysis device is simplified, and the overall cost of the immune analysis device is reduced.

[0078] The above examples are only used to illustrate the present application, and are not a limitation of the present application. Those skilled in the art can make various changes or transformations without departing from the spirit and scope of the present application. Therefore, all equivalent technical solutions should belong to the protection scope of the present application, and the protection scope of the present application should be defined by the claims.

Claims

1. An adjustable support method for an incubation tray in an integrated incubation and cleaning module, characterized in that: The incubation disc is annular, and the cleaning disc is located at the inner circumferential side of the annular incubation disc; the adjustable supporting method is to design the connecting points connecting the annular incubation disc as at least two position-fixed connecting points and at least one position-adjustable connecting point, and to adjust the installation position of the incubation disc by adjusting the position of the at least one position-adjustable connecting point after the cleaning disc is installed, so that the incubation disc is supported and connected at the outer circumferential side of the cleaning disc; The position-fixed connecting point is designed as a position-fixed horizontal guide wheel structure, and the position-adjustable connecting point is designed as a position-adjustable horizontal guide wheel structure, and the incubation disc is supported and connected at the outer circumferential side of the cleaning disc by using the position-fixed horizontal guide wheel structure and the position-adjustable horizontal guide wheel structure; The position-fixed horizontal guide wheel structure comprises a support column one and a horizontal guide wheel one arranged on the top of the support column one, and a guide groove is formed on the circumferential surface of the horizontal guide wheel one; the position-adjustable horizontal guide wheel structure comprises a support column two and a support column three, a swing arm is hinged to the top of the support column two, one end of the swing arm is hinged to the top of the support column two, a swing arm waist hole is formed on the other end of the swing arm, a screw one is screwed into the top of the support column three through the swing arm waist hole, so that the other end of the swing arm is locked on the top of the support column three, and a horizontal guide wheel two is arranged on the swing arm, and a guide groove is also formed on the circumferential surface of the horizontal guide wheel two; The specific steps of the adjustable supporting method are as follows: the inner circumferential part of the incubation disc is clamped into the guide groove of the horizontal guide wheel one of the at least two position-fixed horizontal guide wheel structures and the guide groove of the horizontal guide wheel two of the at least one position-adjustable horizontal guide wheel structure, then the position of the swing arm of the at least one position-adjustable horizontal guide wheel structure is adjusted, so that one U-shaped groove two on the incubation disc and one U-shaped groove one on the cleaning disc can be located on the same radial line B, and then the screw one is locked to lock the swing arm, so that the incubation disc is supported and connected at the outer circumferential side of the cleaning disc.

2. The adjustable support method of claim 1, wherein: An internal reaction cup transfer mechanism is arranged in the integrated incubation and cleaning module, and the internal reaction cup transfer mechanism is used to transfer the reaction cup between the cleaning disc and the incubation disc.

3. The adjustable support method of claim 2, wherein: The U-shaped groove one is used to support the reaction cup, and a plurality of U-shaped grooves one are arranged on the cleaning disc and arranged radially towards the cleaning disc; the U-shaped groove two is also used to support the reaction cup, and a plurality of U-shaped grooves two are arranged on the incubation disc and arranged radially towards the incubation disc; when the cleaning disc and the incubation disc are assembled, the openings of the U-shaped grooves one and the openings of the U-shaped grooves two are arranged opposite to each other and can be located on the same radial line by rotating the cleaning disc and the incubation disc; During the transfer, the internal reaction cup transfer mechanism is used to move the reaction cup from the U-shaped groove one to the U-shaped groove two or from the U-shaped groove two to the U-shaped groove one along the radial direction of the cleaning disc and the incubation disc, so as to transfer the reaction cup between the cleaning disc and the incubation disc.

4. The adjustable support method of claim 3, wherein: The reaction cup internal transfer mechanism comprises an X-axis moving device and a Z-axis moving device arranged on the X-axis moving device, and a transfer cylinder is arranged on the Z-axis moving device, the X-axis moving device and the Z-axis moving device constitute a two-dimensional moving mechanism, the X-axis is arranged along the radial direction of the cleaning disc and the incubation disc, the Z-axis is perpendicular to the direction of the X-axis, the transfer cylinder is driven to move in the two-dimensional direction through the action of the two-dimensional moving mechanism, and finally the reaction cup is transferred back and forth between the cleaning disc and the incubation disc by the transfer cylinder.

5. The adjustable support method of claim 4, wherein: When the reaction cup is transferred from the incubation disc to the cleaning disc, first, the incubation disc and the cleaning disc are controlled to rotate, so that the notch of one U-shaped groove two on the incubation disc and the notch of one U-shaped groove one on the cleaning disc are aligned along the radial direction of the incubation disc and the cleaning disc, and then the specific operation steps are as follows: 1) control the Y-axis moving device to move upwards, so that the transfer cylinder contacts the reaction cup located in the U-shaped groove two and the reaction cup is lifted from the U-shaped groove two during the continuous upward movement of the transfer cylinder; 2) control the X-axis moving device to move along the radial direction towards the cleaning disc, so that the reaction cup is moved out of the notch of the U-shaped groove two and then moved into the notch of the U-shaped groove one, and finally moved to a position above the groove bottom of the U-shaped groove one; 3) control the Y-axis moving device to move downwards, so that the reaction cup is placed into the U-shaped groove one of the cleaning disc; when the transfer cylinder is moved to the position, the transfer cylinder is separated from the reaction cup.

6. The adjustable support method of claim 4, wherein: When the reaction cup is transferred from the cleaning disc to the incubation disc, first, the incubation disc and the cleaning disc are controlled to rotate, so that the notch of one U-shaped groove two on the incubation disc and the notch of one U-shaped groove one on the cleaning disc are aligned along the radial direction of the incubation disc and the cleaning disc, and then the specific operation steps are as follows: S1, control the Y-axis moving device to move upwards, so that the transfer cylinder contacts the reaction cup located in the U-shaped groove one and the reaction cup is lifted from the U-shaped groove one during the continuous upward movement of the transfer cylinder; S2, control the X-axis moving device to move along the radial direction towards the incubation disc, so that the reaction cup is moved out of the notch of the U-shaped groove one and then moved into the notch of the U-shaped groove two, and finally moved to a position above the groove bottom of the U-shaped groove two; S3, control the Y-axis moving device to move downwards, so that the reaction cup is placed into the U-shaped groove two of the incubation disc; when the transfer cylinder is moved to the position, the transfer cylinder is separated from the reaction cup.

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