Traditional Chinese medicine granules for treating icteric hepatitis and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to traditional Chinese medicine granules for treating icteric hepatitis and a preparation method thereof. The traditional Chinese medicine granules are prepared from the following components: herba artemisiae scopariae, herba lysimachiae, fried fructus gardeniae, radix et rhizoma rhei, radix isatidis, herba pogostemonis, herba eupatorii, herba artemisiae annuae, radix paeoniae rubra, cortex moutan, radix salviae miltiorrhizae, fructus crataegi, semen coicis and According to the traditional Chinese medicine composition, the traditional Chinese medicines are scientifically compounded and are mutually assisted and compatible, so that the comprehensive treatment effects of clearing heat, promoting diuresis and giving consideration to exterior syndromes, stasis syndromes and distention and fullness syndromes are achieved, and the traditional Chinese medicine composition is suitable for Yang jaundice diseases in traditional Chinese medicine theories, especially for complex illness conditions with various mixed symptoms such as the exterior syndromes, the stasis syndromes and the distention and fullness syndromes. A comprehensive treatment solution is provided, the application range is wider, and the expected curative effect is more obvious.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to traditional Chinese medicine granules for treating icteric hepatitis and a preparation method thereof. Background Art

[0002] Yang jaundice is a common type of jaundice in TCM clinics, which is called acute / subacute icteric hepatitis in modern medicine. It is mainly manifested by yellow body and eyes, bright orange peel color, accompanied by fever, thirst, short and red urine, etc. Traditional Chinese medicine believes that Yang jaundice is mostly caused by damp-heat accumulation in the liver and gallbladder, and failure to dredge and discharge. However, in clinical practice, patients often not only have the basic pathogenesis of internal damp-heat, but also often have complex conditions such as unresolved external evils, blood stasis, and spleen and stomach distension, which makes treatment more difficult.

[0003] Currently, there are two Chinese herbal formulas for Yang jaundice on the market: Chidan Tuihuang Granules and Yinzhihuang Granules. The following is a detailed analysis of the characteristics and disadvantages of these two similar Chinese herbal formulas:

[0004] ① Chidan anti-jaundice granules:

[0005] a. Ingredients and efficacy: Chidan Tuihuang Granules are mainly composed of Chinese herbs such as red peony root, salvia miltiorrhiza, and kudzu root, which have the effects of cooling blood and clearing liver, promoting blood circulation and relieving jaundice. These ingredients work together to help improve the symptoms of jaundice caused by acute and chronic viral cholestatic hepatitis, such as yellow body and eyes, frequent urination, dry stool, dull pain or discomfort in the ribs, itchy skin, thirst and thirst, etc.

[0006] b. Adverse reactions: Some patients may experience mild bitter taste in the mouth, nausea, mild to moderate diarrhea and other adverse reactions during use. In addition, abnormalities in blood routine, urine routine, and blood creatinine were occasionally found in clinical trials, but it cannot be confirmed that they are directly related to the use of this product. Due to differences in patient constitution and condition, the efficacy of Chidan Tuihuang Granules may vary from patient to patient, and some patients may not achieve the expected therapeutic effect.

[0007] ②Yinzhihuang Granules:

[0008] a. Ingredients and efficacy: Yinzhihuang Granules are mainly composed of Chinese medicinal herbs such as Artemisia capillaris, Gardenia jasminoides and Rhubarb, which have the effects of removing dampness and jaundice, clearing away heat and detoxifying. It is mainly used to treat jaundice caused by liver and gallbladder dampness and heat or poor discharge of bile stasis, and to reduce alanine aminotransferase. It is suitable for the treatment of acute and chronic hepatitis and other diseases.

[0009] b. Adverse reactions: All three drugs in Yinzhihuang Granules are cooling drugs, which can only clear away heat and dampness, but cannot take into account other symptoms. Improper use may cause stomach pain, diarrhea, vomiting, or abdominal distension and indigestion. These adverse reactions may affect the patient's medication experience and treatment effect.

[0010] In summary, commonly used Chinese patent medicine formulas such as Chidan Tuihuang Granules and Yinzhihuang Granules have their own characteristics in terms of ingredients and efficacy, but they also have certain disadvantages and adverse reactions. When developing new Chinese medicine formulas for jaundice, we can learn from the advantages of these products and improve and innovate their disadvantages to improve their efficacy and safety. Summary of the invention

[0011] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art and provide a Chinese medicine granule for treating icteric hepatitis and a preparation method thereof, so as to solve the complex situation of multiple common mixed symptoms in patients with icteric hepatitis, and achieve the goal of clearing away heat and dampness while taking into account superficial symptoms, blood stasis symptoms and abdominal distension symptoms.

[0012] To achieve the above objectives, the technical solutions adopted by the present invention include:

[0013] In a first aspect, the present invention provides a Chinese medicine granule for treating icteric hepatitis, comprising the following components: Artemisia capillaris, Herba Lysimachiae, stir-fried Gardenia jasminoides, Rhubarb, Radix Isatidis, Patchouli, Cymbopogon citratus, Artemisia annua, Paeonia lactiflora, Paeonia suffruticosa, Salvia miltiorrhiza, Crataegus pinnatifida, Coix seeds and Apricot kernel.

[0014] The Chinese medicine granules of the present invention comprise the following four groups of component drugs:

[0015] (1) Heat-clearing and dampness-removing group: Artemisia capillaris, Lysimachia chinensis, stir-fried Gardenia jaundice, Rhubarb, and Isatis indigotica. This group of drugs directly treats the core pathogenesis of Yang jaundice through its effects of clearing heat and dampness, detoxifying and relieving jaundice.

[0016] (2) The group that takes into account the symptoms of the exterior: Patchouli, Cymbopogon citratus, and Artemisia annua. This group of herbs can dispel the exterior pathogens and help relieve the symptoms of the exterior caused by wind-cold or wind-heat, thereby enhancing the body’s resistance.

[0017] (3) Blood stasis group: red peony root, moutan bark, salvia miltiorrhiza; this group of drugs has the effect of promoting blood circulation and removing blood stasis, which can improve the condition of blood stasis, promote blood circulation in the lesion area, and accelerate recovery.

[0018] (4) The group that takes into account the fullness and distension of the spleen and stomach: hawthorn, coix seed, and bitter almond; this group of drugs can strengthen the spleen and digestion, regulate qi and relieve fullness, and treat the common symptoms of fullness and distension of the spleen and stomach in Yanghuang disease, thereby restoring the normal function of the spleen and stomach.

[0019] Qianjin Fang states: "Jaundice is characterized by yellow eyes and abdominal distension, difficulty in urination, yellow body and fever", and Shanghan Lun states: "Yangming disease, fever and sweating, this is due to excessive heat, and jaundice cannot occur. However, if the head sweats, the body does not sweat, and the sweat stops at the neck, urination is difficult, and the patient is thirsty and wants to drink water, this is due to blood stasis and heat in the body, and the body must turn yellow". It can be seen from the descriptions in ancient books that Yang jaundice is often accompanied by symptoms of the exterior, blood stasis, and fullness, and most of them are normal. The classic provisions are basically consistent with clinical findings. The commonly used Chinese patent medicine formulas cannot meet the complex situation of multiple common mixed symptoms. The present invention selects the above-mentioned components of Chinese medicine for scientific compounding, and the medicines complement each other to achieve the comprehensive therapeutic effect of clearing away heat and dampness and taking into account the exterior symptoms, blood stasis, and fullness, thereby providing a comprehensive treatment solution for Yang jaundice in traditional Chinese medicine theory, especially for the complex condition accompanied by multiple mixed symptoms such as exterior symptoms, blood stasis, and fullness, and the scope of application is wider and the expected therapeutic effect is more obvious.

[0020] Preferably, the following components are included in parts by weight: 30-60 parts of Artemisia capillaris, 20-30 parts of Lysimachia chinensis, 10-20 parts of stir-fried Gardenia jasminoides, 10-15 parts of Rhubarb, 15-20 parts of Isatis root, 10-20 parts of Patchouli, 10-20 parts of Cymbidium orientalis, 15-20 parts of Artemisia annua, 20-30 parts of Red Peony Root, 10-20 parts of Paeonia suffruticosa, 15-20 parts of Salvia miltiorrhiza, 15-20 parts of Hawthorn, 15-20 parts of Coix seeds and 10-15 parts of bitter almond.

[0021] Preferably, the following components are included in parts by weight: 45 parts of Artemisia capillaris, 25 parts of Lysimachia chinensis, 15 parts of stir-fried Gardenia jasminoides, 12 parts of Rhubarb, 15 parts of Isatis root, 15 parts of Patchouli, 15 parts of Cyperus rotundus, 15 parts of Artemisia annua, 25 parts of Red Peony Root, 15 parts of Paeonia suffruticosa, 15 parts of Salvia miltiorrhiza, 15 parts of Crataegus pinnatifida, 15 parts of Coix seeds and 12 parts of bitter almonds.

[0022] After investigation, it was found that when the dosage of each component in the Chinese medicine granules of the present invention is the above-mentioned optimal value, the various medicines complement each other and are well compatible. The comprehensive therapeutic effect of clearing away heat and dampness and taking into account exterior symptoms, blood stasis, and fullness is the best. After treatment with the Chinese medicine granules, the transaminase (ALT, AST) in the body of patients with icteric hepatitis significantly decreased, the liver function was significantly improved, and the coagulation indicators also decreased significantly, and the coagulation function recovered faster.

[0023] In a second aspect, the present invention provides a method for preparing the Chinese medicine granules, comprising the following steps:

[0024] (1) soaking the raw material in water, boiling it, filtering it, and obtaining a first extract; then adding water to the filtered medicinal residue and boiling it again, filtering it, and obtaining a second extract;

[0025] (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to make the alcohol content of the extract 55-65%, stirring evenly, letting it stand for precipitation, taking the supernatant, concentrating it to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying;

[0026] (3) taking the remaining drug residue after filtering, crushing it, adding 55-65% ethanol solution to extract by percolation method, collecting the percolation liquid, concentrating it under low pressure to a thick paste, adding pharmaceutically acceptable excipients, stirring well, granulating, and drying;

[0027] (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules.

[0028] The preparation method of the Chinese medicine granules of the present invention is simple and easy, ensuring that the effective ingredients of the medicine are retained and the best therapeutic effect is achieved. In addition, the amount of dressing that needs to be added in large quantities in the Chinese medicine granule preparation is greatly reduced, and the Chinese medicine granule preparation is suitable for large-scale industrial production and has broad market prospects and application value.

[0029] Preferably, in step (1), water is added for 1-2 hours, the amount of water added for the first time is 15 times the mass of the raw material, and the amount of water added for the second time is 10 times the mass of the raw material. The medicinal materials need to be soaked before extraction to make the effective ingredients easier to dissolve, and the appropriate amount of water needs to be determined based on the water absorption of the medicinal materials and the content of the effective ingredients. Generally speaking, the amount of water added should be able to fully soak the medicinal materials, but not too much, so as not to affect the extraction efficiency.

[0030] Preferably, in step (1), the first boiling time is 1.5-2 h, and the second boiling time is 1-1.5 h.

[0031] Preferably, in step (3), the amount of ethanol solution added is 3-5 times the mass of the medicinal residue.

[0032] In a third aspect, the present invention provides the use of the Chinese medicine granules in the preparation of a medicine for treating icteric hepatitis.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] (1) The present invention selects the aforementioned Chinese medicines for scientific compounding, and the various medicines complement each other to achieve a comprehensive therapeutic effect of clearing away heat and dampness and taking into account the symptoms of the exterior, blood stasis, and fullness. Thus, for Yang jaundice in traditional Chinese medicine theory, especially for the complex condition accompanied by multiple mixed symptoms such as the symptoms of the exterior, blood stasis, and fullness, a comprehensive treatment solution is provided, and the scope of application is wider and the expected therapeutic effect is more obvious;

[0035] (2) The preparation method of the Chinese medicine granules of the present invention is simple and easy, ensuring that the effective ingredients of the medicine are retained and the best therapeutic effect is achieved. In addition, the amount of dressing that needs to be added in large quantities in the Chinese medicine granule preparation is greatly reduced, which is suitable for large-scale industrial production and has broad market prospects and application value. DETAILED DESCRIPTION

[0036] To better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. It should be understood by those skilled in the art that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0037] Example 1

[0038] The present embodiment provides a traditional Chinese medicine granule for treating icteric hepatitis, comprising the following components in parts by weight: 45 parts of Artemisia capillaris, 25 parts of Lysimachia chinensis, 15 parts of stir-fried Gardenia jasminoides, 12 parts of Rhubarb, 15 parts of Isatis indigotica, 15 parts of Patchouli, 15 parts of Cyperus rotundus, 15 parts of Artemisia annua, 25 parts of Red Peony Root, 15 parts of Paeonia suffruticosa, 15 parts of Salvia miltiorrhiza, 15 parts of Crataegus pinnatifida, 15 parts of Coix seeds and 12 parts of Apricot kernel.

[0039] The preparation method of the Chinese medicine granules comprises the following steps:

[0040] (1) adding water to the raw material and soaking it for 1.5 hours, the amount of water added for the first time being 15 times the weight of the raw material, boiling it for 2 hours, filtering it, and obtaining a first extract, then adding water to the filtered medicinal residue and boiling it again for 1.5 hours, the amount of water added for the second time being 10 times the weight of the raw material, filtering it, and obtaining a second extract;

[0041] (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to make the alcohol content of the extract 55-65%, stirring evenly, letting it stand for precipitation, taking the supernatant, concentrating it to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying;

[0042] (3) taking the remaining drug residue after filtration, crushing it, passing it through an 80-120 mesh sieve, adding 4 times the amount of 60% ethanol solution to extract it by percolation, collecting the percolation liquid, concentrating it under low pressure to a thick paste, adding pharmaceutically acceptable excipients, stirring it evenly, granulating it, and drying it;

[0043] (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules. During the granulation process, the size and uniformity of the granules need to be controlled.

[0044] Example 2

[0045] The present embodiment provides a Chinese medicine granule for treating icteric hepatitis, comprising the following components in parts by weight: 30 parts of Artemisia capillaris, 20 parts of Lysimachia chinensis, 10 parts of stir-fried Gardenia jasminoides, 10 parts of Rhubarb, 15 parts of Isatis indigotica, 10 parts of Patchouli, 10 parts of Perilla frutescens, 15 parts of Artemisia annua, 20 parts of Red Peony Root, 10 parts of Paeonia suffruticosa, 15 parts of Salvia miltiorrhiza, 15 parts of Crataegus pinnatifida, 15 parts of Coix seeds, and 10 parts of Apricot kernel;

[0046] The preparation method of the Chinese medicine granules comprises the following steps:

[0047] (1) adding water to the raw material and soaking it for 1 hour, the amount of water added for the first time is 15 times the weight of the raw material, boiling it for 1.5 hours, filtering it, and obtaining a first extract, then adding water to the filtered medicinal residue and boiling it again for 1 hour, the amount of water added for the second time is 10 times the weight of the raw material, filtering it, and obtaining a second extract;

[0048] (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to make the alcohol content of the extract 55-65%, stirring evenly, letting it stand for precipitation, taking the supernatant, concentrating it to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying;

[0049] (3) taking the remaining drug residue after filtration, crushing it, passing it through an 80-120 mesh sieve, adding 3 times the amount of 55% ethanol solution to extract it by percolation, collecting the percolation liquid, concentrating it under low pressure to a thick paste, adding pharmaceutically acceptable excipients, stirring it evenly, granulating it, and drying it;

[0050] (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules. During the granulation process, the size and uniformity of the granules need to be controlled.

[0051] Example 3

[0052] The present embodiment provides a Chinese medicine granule for treating icteric hepatitis, comprising the following components in parts by weight: 60 parts of Artemisia capillaris, 30 parts of Lysimachia chinensis, 20 parts of stir-fried Gardenia jasminoides, 15 parts of Rhubarb, 20 parts of Isatis indigotica, 20 parts of Patchouli, 20 parts of Perilla frutescens, 20 parts of Artemisia annua, 30 parts of Red Peony Root, 20 parts of Paeonia suffruticosa, 20 parts of Salvia miltiorrhiza, 20 parts of Crataegus pinnatifida, 20 parts of Coix seeds, and 15 parts of Apricot kernel;

[0053] The preparation method of the Chinese medicine granules comprises the following steps:

[0054] (1) adding water to the raw material and soaking it for 2 hours, the amount of water added for the first time being 15 times the weight of the raw material, boiling it for 2 hours, filtering it, and obtaining a first extract, then adding water to the filtered medicinal residue and boiling it again for 1.5 hours, the amount of water added for the second time being 11 times the weight of the raw material, filtering it, and obtaining a second extract;

[0055] (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to make the alcohol content of the extract 55-65%, stirring evenly, letting it stand for precipitation, taking the supernatant, concentrating it to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying;

[0056] (3) taking the remaining drug residue after filtration, crushing it, passing it through an 80-120 mesh sieve, adding 5 times the amount of 65% ethanol solution to extract it by percolation, collecting the percolation liquid, concentrating it under low pressure to a thick paste, adding pharmaceutically acceptable excipients, stirring it evenly, granulating it, and drying it;

[0057] (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules. During the granulation process, the size and uniformity of the granules need to be controlled.

[0058] Comparative Example 1

[0059] This comparative example provides a Chinese medicine granule, which only includes the following components in parts by weight: 40 parts of Artemisia capillaris, 25 parts of Lysimachia chinensis, 15 parts of stir-fried Gardenia jasminoides, 12 parts of Rhubarb, and 18 parts of Radix Isatidis;

[0060] The preparation method of the Chinese medicine granules is the same as that in Example 1.

[0061] Effect example

[0062] In order to verify the efficacy of the Chinese herbal granules of the present invention in treating icteric hepatitis, the inventors conducted a clinical trial study on patients with icteric hepatitis of Yanghuang syndrome.

[0063] (1) Clinical data

[0064] 1. Case selection: The 62 selected cases were all patients with icteric hepatitis with Yanghuang syndrome who came to our department for treatment from July 2022 to July 2024; all patients were randomly divided into an observation group and a control group, with 31 people in each group. There was no statistically significant difference in age, gender, and clinical symptoms before treatment between the two groups, and they were comparable.

[0065] 2. Diagnostic criteria: refer to the "Guiding Principles for Clinical Research of New Chinese Medicines".

[0066] 3. Treatment methods:

[0067] Observation group: taking the Chinese medicine granules described in Example 1 of the present invention, twice a day, 10 g each time, taken with boiled water, 30 days as a course of treatment, two courses of treatment in a row;

[0068] Control group: taking the Chinese medicine granules described in Comparative Example 1 of the present invention and conventional liver-protecting and enzyme-reducing drugs for tailored treatment, twice a day, 10 g each time, taken with boiled water, 30 days as a course of treatment, and two courses of treatment are taken in succession.

[0069] Table 1 compares the baseline data and symptom distribution of the two groups of patients with icteric hepatitis before treatment.

[0070] Table 1

[0071]

[0072] (2) Changes in liver function and coagulation indexes before and after treatment

[0073] As shown in Table 2, by comparing the improvement before and after treatment, it was found that the decrease in transaminase (ALT, AST) in the observation group was significantly better than that in the control group (P<0.01); the decrease in total bilirubin and direct bilirubin in the observation group was also better than that in the control group (P<0.05). In terms of coagulation function, the decrease in prothrombin time and INR in the observation group was significantly better than that in the control group (P<0.01), indicating that the coagulation function recovered faster. In terms of obstructive enzyme GGT and ALP, the control group was slightly better than the observation group, but the comparison between the two groups was not statistically significant.

[0074] Table 2 Decrease in liver function and coagulation indexes of patients after treatment

[0075]

[0076]

[0077] Note: ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, glutamyltransferase; ALP, alkaline phosphatase; TBIL, total bilirubin; DBIL, direct bilirubin; PT, prothrombin time; INR, international normalized ratio.

[0078] (3) Changes in TCM syndrome scores before and after treatment

[0079] The results revealed that the Chinese medicine granules prepared in the embodiment of the present invention have better clinical effects on improving TCM syndromes. As shown in Table 3, all clinical symptoms of the observation group were improved before and after treatment. Compared with the control group after treatment, the observation group was better than the control group in terms of flank pain, aversion to oil, abdominal pain, and constipation (P<0.05); and was significantly better than the control group in terms of bitter mouth, dry mouth, nausea, hiccups, etc. (P<0.01). No adverse reactions related to treatment occurred in patients in each group after treatment.

[0080] Table 3

[0081]

[0082]

[0083] Compared with the observation group before treatment, #P<0.01; compared with the control group, *P<0.05, **P<0.01

[0084] (3) Comparison of total effective rate and hospitalization days between the two groups

[0085] As shown in Table 4, the total effective rate of the observation group was 93.55%, which was better than 74.19% of the control group (P<0.01). In terms of the length of hospital stay, the average length of hospital stay in the observation group was nearly 2.5 days shorter than that in the control group, and the difference between the two groups in length of hospital stay was statistically significant (P<0.05).

[0086] Table 4

[0087] Group Number of cases Significant effect efficient invalid Total Effectiveness Number of days in hospital Observation Group 31 15(48.39) 14(45.16) 2(6.45) 93.55 11.35±2.86 Control group 31 11(35.48) 12(38.71) 8(25.81) 74.19 13.84±3.12 t / χ2 / 6.21 4.78 11.97 8.79 2.34 P / <0.05 <0.05 <0.01 <0.01 <0.05

[0088] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A Chinese medicine granule for treating icteric hepatitis, characterized in that: The ingredients include: Artemisia capillaris, Centella asiatica, stir-fried Gardenia jasminoides, Rhubarb, Isatis root, Patchouli, Cymbidium orientalis, Artemisia annua, Red Peony Root, Paeonia suffruticosa, Salvia miltiorrhiza, Hawthorn, Coix seed and bitter almond.

2. The Chinese medicine granules according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 30-60 parts of Artemisia capillaris, 20-30 parts of Lysimachia chinensis, 10-20 parts of stir-fried Gardenia jasminoides, 10-15 parts of Rhubarb, 15-20 parts of Isatis indigotica, 10-20 parts of Patchouli, 10-20 parts of Cymbidium eupatorium, 15-20 parts of Artemisia annua, 20-30 parts of Red Peony Root, 10-20 parts of Paeonia suffruticosa, 15-20 parts of Salvia miltiorrhiza, 15-20 parts of Hawthorn, 15-20 parts of Coix seeds and 10-15 parts of bitter almonds.

3. The Chinese medicine granules according to claim 2, characterized in that: The invention comprises the following raw materials in parts by weight: 45 parts of Artemisia capillaris, 25 parts of Lysimachia chinensis, 15 parts of stir-fried Gardenia jasminoides, 12 parts of Rhubarb, 15 parts of Isatis indigotica, 15 parts of Patchouli, 15 parts of Cyperus rotundus, 15 parts of Artemisia annua, 25 parts of Red Peony Root, 15 parts of Paeonia suffruticosa, 15 parts of Salvia miltiorrhiza, 15 parts of Crataegus pinnatifida, 15 parts of Coix seeds and 12 parts of Bitter Apricot Kernel.

4. The method for preparing the Chinese medicine granules according to any one of claims 1 to 3, characterized in that: The following steps are involved: (1) soaking the raw materials in water, boiling them for the first time, filtering them to obtain a first extract, and then adding water to the filtered medicinal residues to boil them for the second time, filtering them to obtain a second extract; (2) combining the first extract and the second extract, concentrating to a relative density of 1.25-1.30, adding 75% ethanol solution to make the alcohol content of the extract 55-65%, stirring evenly, letting it stand for precipitation, taking the supernatant, concentrating it to a thick paste, adding pharmaceutically acceptable excipients, stirring evenly, granulating, and drying; (3) taking the remaining drug residue after filtering, crushing it, adding 55-65% ethanol solution to extract by percolation method, collecting the percolation liquid, concentrating it under low pressure to a thick paste, adding pharmaceutically acceptable excipients, stirring well, granulating, and drying; (4) The granules obtained in step (2) and step (3) are mixed uniformly to obtain the Chinese medicine granules.

5. The preparation method according to claim 4, characterized in that: In the step (1), water is added for soaking for 1-2 hours, the amount of water added for the first time is 15 times the mass of the raw material, and the amount of water added for the second time is 10 times the mass of the raw material.

6. The preparation method according to claim 4, characterized in that: In the step (1), the first boiling time is 1.5-2 hours, and the second boiling time is 1-1.5 hours.

7. The preparation method according to claim 4, characterized in that: In the step (3), the amount of the ethanol solution added is 3-5 times the mass of the medicinal residue.

8. Use of the Chinese medicine granules according to any one of claims 1 to 3 in the preparation of a medicament for treating icteric hepatitis.

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