Antibacterial medical silica gel material and preparation method thereof
By grafting specific chemical substances and antibacterial peptides on the surface of silica gel particles and combining silver nanoparticles, the problem of insufficient antibacterial performance of traditional medical silicone materials is solved, efficient antibacterial sterilization and biocompatibility improvement are achieved, and production costs are reduced .
Patent Information
- Application Number
- CN202411197935.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-29
- Publication Date
- 2024-12-10
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Traditional medical silicone materials lack antibacterial and bactericidal ability, leading to infection risk. The existing inorganic antibacterial agents have poor compatibility and poor thermal stability, while the organic antibacterial agents have poor thermal stability and are easy to decompose, which limits their application.
Dispersibility is increased by grafting gamma-methacryloyloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane on the surface of silica gel particles, and then grafting copolymers of 4-vinylpyridine and acrylamide , and then graft the antimicrobial peptide, combine polyvinylpyrrolidone-capped silver nanoparticles with vancomycin and amikacin to prepare modified silica gel materials to enhance antimicrobial properties and biocompatibility.
It significantly improves the antibacterial sterilization activity and biocompatibility of silicone materials, reduces production costs, simplifies the preparation process, and improves the overall performance of the materials.
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Figure BDA0005017029640000101
Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of medical material preparation, and in particular, relates to an antibacterial medical silica gel material and a preparation method thereof. Background Art
[0002] Silicone has good biocompatibility, is non-irritating, non-toxic, and non-allergic to human tissues, has few body rejection reactions, and has good physical and chemical properties. It is a fairly stable inert substance. At the same time, due to its high thermal stability, excellent weather resistance, good electrical insulation, and low surface tension and surface energy, it is widely used in aviation, textiles, machinery, and medical and medical fields. Silicone materials in the prior art are mainly divided into two categories: organic silicone and inorganic silicone. The main component of inorganic silicone is silicon dioxide, which is a small molecule structure. Organic silicone is a general term for many polymer compounds containing silicon elements. Its main chain is composed of silicon-oxygen bonds, and the side chains can link various organic groups. It has the dual properties of inorganic and organic polymers.
[0003] At present, although there are many types of medical silicone on the market, they usually have the following defects: (1) Traditional medical silicone materials do not have the ability to kill bacteria and bacteria. During use, they may cause infection and affect the health of patients. Therefore, silicone materials are improved by adding inorganic antibacterial agents to achieve the antibacterial purpose. However, the antibacterial effect of inorganic antibacterial agents is not very good, and they are not compatible with the silicone base material, and are not easy to disperse evenly. Long-term use is prone to extravasation, so they are limited in practical applications; (2) Traditional medical silicone materials achieve the antibacterial purpose by adding organic antibacterial agents, and their antibacterial performance is not very good. Although organic antibacterial agents can effectively inhibit the production and reproduction of harmful bacteria and molds, they have poor thermal stability and are easy to decompose. Therefore, it is necessary to produce an antibacterial medical silicone material that not only has good antibacterial activity, but also has good biocompatibility and thermal stability, low production cost and simple preparation process. Summary of the invention
[0004] The object of the present invention is to provide an antibacterial medical silica gel material and a preparation method thereof. The modified silica gel particles are prepared by grafting γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane on the surface of silica gel particles, a silane coupling agent increases the dispersibility of the silica gel particles to prevent them from agglomerating, and then a copolymer of 4-vinylpyridine and acrylamide is grafted on the surface of the modified silica gel particles, and then an antimicrobial peptide is grafted to prepare the modified medical silica gel material. The copolymer of 4-vinylpyridine and acrylamide improves the antibacterial property of the silica gel material, and the antimicrobial peptide further enhances the antibacterial and sterilization activity of the silica gel material, thereby achieving the purpose of effective sterilization, and also improving the biocompatibility and thermal stability with the silica gel material, while reducing the production cost, and the preparation process is simple, and the comprehensive performance of the silica gel material is further improved.
[0005] Technical problem to be solved by the present invention: Traditional medical silicone materials do not have the ability of antibacterial and sterilization, and may cause infection during use, affecting the health of patients. Therefore, the silicone material is improved by adding inorganic antibacterial agents to achieve the antibacterial purpose, but the antibacterial effect of inorganic antibacterial agents is not very good, and the compatibility with the silicone base material is not good, and it is not easy to disperse evenly, and it is easy to cause extravasation after long-term use; traditional medical silicone materials achieve the antibacterial purpose by adding organic antibacterial agents, and their antibacterial performance is not very good. Although organic antibacterial agents can effectively inhibit the production and reproduction of harmful bacteria and molds, they have poor thermal stability and are easy to decompose, so they are limited in practical applications.
[0006] The purpose of the present invention can be achieved by the following technical solutions:
[0007] An antibacterial medical silicone material comprises the following raw materials in parts by weight: 80-100 parts of modified medical silicone material, 1-3 parts of antibacterial agent and 0.5-1 part of vulcanizing agent;
[0008] The modified medical silica gel material is prepared by grafting a copolymer of 4-vinylpyridine and acrylamide onto the surface of modified silica gel particles, and then grafting antimicrobial peptides; the modified silica gel particles are prepared by grafting γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane onto the surface of silica gel particles; and the antibacterial agent is prepared by coupling silver nanoparticles capped with polyvinylpyrrolidone with the surfaces of vancomycin and amikacin.
[0009] Further, the modified medical silica gel material comprises the following steps to prepare:
[0010] A1: Modified silica gel particles are mixed with a copolymer of 4-vinylpyridine and acrylamide, and then azobisisobutyronitrile is added. After mixing evenly, the mixture is reacted at a constant temperature of 65°C for 7 hours under a nitrogen atmosphere, and the mixture is filtered, extracted with toluene for 20 hours, and then washed with ethanol for 3 times. After drying under vacuum for 24 hours, modified silica gel particles grafted with the copolymer are obtained, wherein the amount ratio of the modified silica gel particles, the copolymer of 4-vinylpyridine and acrylamide, azobisisobutyronitrile, toluene and ethanol is 2-3g:1-2g:30-40mL:20-30mL:25-30mL;
[0011] A2: The copolymer-grafted modified silica gel particles are transferred to an activated antimicrobial peptide solution, reacted at room temperature for 2 hours, washed three times with deionized water and 4-hydroxyethylpiperazineethanesulfonic acid buffer, and then dried at 60°C for 1 hour to obtain a modified medical silica gel material, wherein the amount ratio of the copolymer-grafted modified silica gel particles, the antimicrobial peptide solution, the deionized water and the 4-hydroxyethylpiperazineethanesulfonic acid buffer is 1-2g:25-35mL:20-25mL:15-20mL.
[0012] In the above reaction process, the surface of the modified silica gel particles has carbon-carbon double bonds and amino groups, the copolymer of 4-vinylpyridine and acrylamide has carbon-carbon double bonds, which can react with the carbon-carbon double bonds on the modified silica gel particles, and the copolymer of 4-vinylpyridine and acrylamide is grafted onto the modified silica gel particles, while the antimicrobial peptide has an amide group, which can react with the amino group on the modified silica gel particles, and the antimicrobial peptide is grafted onto the modified silica gel particles.
[0013] Furthermore, in step A1, the modified silica gel particles are prepared by the following steps:
[0014] Silica gel particles and a 5% methanesulfonic acid aqueous solution are mixed, stirred at 102° C. for 4 hours, centrifuged, washed with deionized water for 3 times, and dried under vacuum for 24 hours. The mixture is added to ethanol, and then γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane are added, and then deionized water is added. In a nitrogen atmosphere, the mixture is reacted at 50° C. for 24 hours, washed with ethanol and filtered, and dried under vacuum to obtain modified silica gel particles, wherein the amount ratio of silica gel particles, methanesulfonic acid aqueous solution, deionized water, ethanol, γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane is 1-2g:50-60mL:20-25mL:20-30mL:20-25mL:15-20mL.
[0015] During the above reaction process, the surface of the silica gel particles has hydroxyl groups. After hydrolysis of γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane, silicon hydroxyl groups are generated, which can react with the hydroxyl groups on the silica gel particles, thereby grafting γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane onto the silica gel particles.
[0016] Furthermore, the antibacterial agent is prepared by the following steps:
[0017] A silver nitrate solution with a concentration of 1 mol / L and a sodium borohydride solution with a concentration of 2 mol / L are mixed, polyvinyl pyrrolidone is added, and the mixture is continuously stirred in an ice bath until the color of the solution changes to light yellow, and then vancomycin and amikacin with a concentration of 0.1-0.5 mol / L are added to the mixed solution, and magnetic stirring is performed at room temperature for 15-20 minutes to obtain an antibacterial agent, wherein the amount ratio of the silver nitrate solution, the sodium borohydride solution, the polyvinyl pyrrolidone, the vancomycin and the amikacin is 10-15 mL: 20-25 mL: 6-8 mL: 0.5-1 mL: 0.1-0.5 mL.
[0018] In the above reaction process, silver nitrate is reduced to silver nanoparticles by sodium borohydride, nitrogen atoms in polyvinyl pyrrolidone are combined with the surface of silver nanoparticles through coordination bonds, and polyvinyl pyrrolidone is adsorbed on the silver nanoparticles. Vancomycin and amikacin have amine groups, and oxygen atoms on polyvinyl pyrrolidone can undergo nucleophilic substitution reaction with hydrogen atoms on the amine groups of vancomycin and amikacin, so that vancomycin and amikacin are combined with silver nanoparticles.
[0019] Furthermore, the vulcanizing agent is an A / B two-component platinum vulcanizing agent or a vulcanizing agent of double 25.
[0020] A method for preparing an antibacterial medical silicone material comprises the following steps:
[0021] The modified medical silicone material and the vulcanizing agent are placed in a mixer, mixed evenly at room temperature, and then the antibacterial agent is added, and the mixing is continued evenly at room temperature, and then high-temperature vulcanization is performed at 120-170°C to finally obtain the antibacterial medical silicone material.
[0022] Beneficial effects of the present invention:
[0023] (1) In the technical scheme of the present invention, the surface of the modified silica gel particles has carbon-carbon double bonds and amino groups. The copolymer of 4-vinylpyridine and acrylamide has carbon-carbon double bonds, which can react with the carbon-carbon double bonds on the modified silica gel particles. The copolymer of 4-vinylpyridine and acrylamide is grafted onto the modified silica gel particles, thereby increasing the antibacterial activity of the modified silica gel particles. The greater the degree of grafting, the stronger the antibacterial ability. The antimicrobial peptide has an amide group, which can react with the amino group on the modified silica gel particles. The antimicrobial peptide is grafted onto the modified silica gel particles. The antimicrobial peptide further enhances the antibacterial and sterilization performance of the modified silica gel particles, thereby achieving the purpose of effective antibacterial, reducing the production cost, and simplifying the preparation process.
[0024] (2) In the technical solution of the present invention, the surface of the silica gel particles has hydroxyl groups. After hydrolysis of γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane, silanol groups are generated, which can react with the hydroxyl groups on the silica gel particles. γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane are grafted onto the silica gel particles. The silane coupling agent-modified silica gel particles increase their dispersibility, prevent their agglomeration, and improve the compatibility and thermal stability of the polymer and the silica gel particles.
[0025] (3) In the technical solution of the present invention, silver nitrate is reduced to silver nanoparticles by sodium borohydride, and the nitrogen atoms in polyvinyl pyrrolidone are combined with the surface of silver nanoparticles through coordination bonds, so that polyvinyl pyrrolidone is adsorbed on the silver nanoparticles, thereby increasing the stability of the silver nanoparticles. Vancomycin and amikacin have amine groups, and the oxygen atoms on polyvinyl pyrrolidone can undergo nucleophilic substitution reactions with the hydrogen atoms on the amine groups of vancomycin and amikacin, thereby combining vancomycin and amikacin with the silver nanoparticles, thereby enhancing the synergistic antibacterial effect of the antibiotics and the silver nanoparticles. Polyvinyl pyrrolidone can also be combined with the silane coupling agent on the modified silica gel particles, thereby increasing the hydrophilicity of the silica gel particles and increasing the biocompatibility of the silver nanoparticles with the silica gel material, thereby effectively enhancing the antibacterial and sterilization activity of the modified medical silica gel material. DETAILED DESCRIPTION
[0026] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0027] Example 1
[0028] The antibacterial agent comprises the following steps:
[0029] 10 mL of 1 mol / L silver nitrate solution and 20 mL of 2 mol / L sodium borohydride solution were mixed, and 6 mL of polyvinyl pyrrolidone was added, and the mixture was continuously stirred in an ice bath until the color of the solution changed to light yellow, and then 0.5 mL of 0.1 mol / L vancomycin and 0.1 mL of amikacin were added to the mixed solution, and magnetic stirring was performed at room temperature for 15-20 minutes to obtain an antibacterial agent.
[0030] Example 2
[0031] The antibacterial agent comprises the following steps:
[0032] 13 mL of 1 mol / L silver nitrate solution and 23 mL of 2 mol / L sodium borohydride solution were mixed, and 7 mL of polyvinyl pyrrolidone was added, and the mixture was continuously stirred in an ice bath until the color of the solution changed to light yellow, and then 0.8 mL of 0.3 mol / L vancomycin and 0.3 mL of amikacin were added to the mixed solution, and magnetic stirring was performed at room temperature for 15-20 minutes to obtain an antibacterial agent.
[0033] Example 3
[0034] The antibacterial agent comprises the following steps:
[0035] 15 mL of 1 mol / L silver nitrate solution and 25 mL of 2 mol / L sodium borohydride solution were mixed, and 8 mL of polyvinyl pyrrolidone was added, and the mixture was continuously stirred in an ice bath until the color of the solution changed to light yellow, and then 1 mL of 0.5 mol / L vancomycin and 0.5 mL of amikacin were added to the mixed solution, and magnetic stirring was performed at room temperature for 15-20 minutes to obtain an antibacterial agent.
[0036] Comparative Example 1
[0037] This comparative example is an antibacterial agent without adding vancomycin and amikacin.
[0038] Example 4
[0039] The modified silica gel particles are prepared by the following steps:
[0040] 1 g of silica gel particles and 50 mL of a 5% methanesulfonic acid aqueous solution were mixed, stirred at 102° C. for 4 hours, centrifuged, washed three times with 20 mL of deionized water, and dried under vacuum for 24 hours. The mixture was added to 20 mL of ethanol, and then 20 mL of γ-methacryloxypropyltrimethoxysilane and 15 mL of 3-aminopropyltrimethoxysilane were added, and then deionized water was added. The mixture was reacted at 50° C. for 24 hours in a nitrogen atmosphere, washed with ethanol and filtered, and dried under vacuum to obtain modified silica gel particles.
[0041] Example 5
[0042] The modified silica gel particles are prepared by the following steps:
[0043] 1.5 g of silica gel particles and 55 mL of a 5% methanesulfonic acid aqueous solution were mixed, stirred at 102° C. for 4 hours, centrifuged, washed three times with 23 mL of deionized water, and dried under vacuum for 24 hours. The mixture was added to 25 mL of ethanol, and then 23 mL of γ-methacryloxypropyltrimethoxysilane and 18 mL of 3-aminopropyltrimethoxysilane were added, and then deionized water was added. The mixture was reacted at 50° C. in a nitrogen atmosphere for 24 hours, washed with ethanol and filtered, and dried under vacuum to obtain modified silica gel particles.
[0044] Example 6
[0045] The modified silica gel particles are prepared by the following steps:
[0046] 2 g of silica gel particles and 60 mL of a 5% methanesulfonic acid aqueous solution were mixed, stirred at 102° C. for 4 hours, centrifuged, washed three times with 25 mL of deionized water, and dried under vacuum for 24 hours. The mixture was added to 30 mL of ethanol, and then 25 mL of γ-methacryloxypropyltrimethoxysilane and 20 mL of 3-aminopropyltrimethoxysilane were added, and then deionized water was added. The mixture was reacted at 50° C. for 24 hours in a nitrogen atmosphere, washed with ethanol and filtered, and dried under vacuum to obtain modified silica gel particles.
[0047] Comparative Example 2
[0048] This comparative example is silica gel particles that have not been modified with silane.
[0049] Example 7
[0050] The modified medical silica gel material comprises the following steps to prepare:
[0051] A1: 2 g of the modified silica gel particles prepared in Example 4 were mixed with 1 g of a copolymer of 4-vinylpyridine and acrylamide, and 30 mL of azobisisobutyronitrile was added. After mixing evenly, the mixture was reacted at a constant temperature of 65° C. under a nitrogen atmosphere for 7 hours. The mixture was filtered, extracted with 20 mL of toluene for 20 hours, and then washed with 25 mL of ethanol for 3 times. After drying under vacuum for 24 hours, modified silica gel particles grafted with the copolymer were obtained;
[0052] A2: 1 g of copolymer-grafted modified silica gel particles were transferred to 25 mL of activated antimicrobial peptide solution, reacted at room temperature for 2 hours, washed three times with 20 mL of deionized water and 15 mL of 4-hydroxyethylpiperazineethanesulfonic acid buffer, and then dried at 60 ° C for 1 hour to obtain modified medical silica gel material.
[0053] Example 8
[0054] The modified medical silica gel material comprises the following steps to prepare:
[0055] A1: 2.5 g of the modified silica gel particles prepared in Example 5 were mixed with 1.5 g of a copolymer of 4-vinylpyridine and acrylamide, and 35 mL of azobisisobutyronitrile was added. After mixing evenly, the mixture was reacted at a constant temperature of 65° C. under a nitrogen atmosphere for 7 hours. The mixture was filtered, extracted with 25 mL of toluene for 20 hours, and then washed with 28 mL of ethanol for 3 times. After drying under vacuum for 24 hours, modified silica gel particles grafted with the copolymer were obtained;
[0056] A2: 1.5 g of copolymer-grafted modified silica gel particles were transferred to 30 mL of activated antimicrobial peptide solution, reacted at room temperature for 2 hours, washed three times with 23 mL of deionized water and 18 mL of 4-hydroxyethylpiperazineethanesulfonic acid buffer, and then dried at 60 ° C for 1 hour to obtain a modified medical silica gel material.
[0057] Example 9
[0058] The modified medical silica gel material comprises the following steps to prepare:
[0059] A1: 3 g of the modified silica gel particles prepared in Example 6 were mixed with 2 g of a copolymer of 4-vinylpyridine and acrylamide, and 40 mL of azobisisobutyronitrile was added. After mixing evenly, the mixture was reacted at a constant temperature of 65° C. under a nitrogen atmosphere for 7 hours. The mixture was filtered, extracted with 30 mL of toluene for 20 hours, and then washed with 30 mL of ethanol for 3 times. After drying under vacuum for 24 hours, modified silica gel particles grafted with the copolymer were obtained;
[0060] A2: 2 g of copolymer-grafted modified silica gel particles were transferred to 35 mL of activated antimicrobial peptide solution, reacted at room temperature for 2 hours, washed three times with 25 mL of deionized water and 20 mL of 4-hydroxyethylpiperazineethanesulfonic acid buffer, and then dried at 60 ° C for 1 hour to obtain a modified medical silica gel material.
[0061] Comparative Example 3
[0062] The difference between this comparative example and Example 8 is that the modified silica gel particles prepared in Example 5 are replaced by the material prepared in Comparative Example 2, and the remaining steps and raw materials are the same as in Example 8.
[0063] Example 10
[0064] An antibacterial medical silicone material comprises the following raw materials in parts by weight: 80 parts of the modified medical silicone material prepared in Example 7, 1 part of the antibacterial agent prepared in Example 1, and 0.5 parts of a vulcanizing agent.
[0065] The following steps are involved:
[0066] The modified medical silicone material and the vulcanizing agent prepared in Example 7 are placed in a mixer, mixed evenly at room temperature, and then the antibacterial agent prepared in Example 1 is added, and the mixing is continued evenly at room temperature, and then high-temperature vulcanization is performed at 120°C to finally obtain an antibacterial medical silicone material.
[0067] Embodiment 11
[0068] An antibacterial medical silicone material comprises the following raw materials in parts by weight: 90 parts of the modified medical silicone material prepared in Example 8, 2 parts of the antibacterial agent prepared in Example 2, and 0.8 parts of a vulcanizing agent.
[0069] The following steps are involved:
[0070] The modified medical silicone material and the vulcanizing agent prepared in Example 8 are placed in a mixer, mixed evenly at room temperature, and then the antibacterial agent prepared in Example 2 is added, and the mixing is continued evenly at room temperature, and then high-temperature vulcanization is performed at 150°C to finally obtain an antibacterial medical silicone material.
[0071] Example 12
[0072] An antibacterial medical silicone material comprises the following raw materials in parts by weight: 100 parts of the modified medical silicone material prepared in Example 9, 3 parts of the antibacterial agent prepared in Example 3, and 1 part of a vulcanizing agent.
[0073] The following steps are involved:
[0074] The modified medical silicone material prepared in Example 9 and the vulcanizing agent are placed in a mixer, mixed evenly at room temperature, and then the antibacterial agent prepared in Example 3 is added, and the mixing is continued evenly at room temperature, and then high-temperature vulcanization is performed at 170°C to finally obtain an antibacterial medical silicone material.
[0075] Comparative Example 4
[0076] The difference between this comparative example and Example 11 is that the modified medical silicone material prepared in Example 8 is replaced by the material prepared in Comparative Example 3, and the antibacterial agent prepared in Example 2 is replaced by the material prepared in Comparative Example 1, and the remaining steps and raw materials are the same as in Example 11.
[0077] The antibacterial medical silica gel materials prepared in Examples 10-12 and Comparative Example 4 were tested for performance according to GB / T528-2009 and GB / T 4789.2. The test results are shown in the following table:
[0078] Table 1
[0079] project Tensile strength(MPa) Example 10 6.0 Embodiment 11 6.2 Example 12 5.9 Comparative Example 4 3.1
[0080] Table 2
[0081]
[0082] It can be seen from Tables 1 and 2 above that the antibacterial medical silicone materials prepared in Examples 10-12 are compared with Comparative Example 4. The modified silica gel particles are prepared by grafting γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane on the surface of the silica gel particles, thereby increasing the dispersibility of the silica gel particles and preventing them from agglomerating. Then, a copolymer of 4-vinylpyridine and acrylamide is grafted on the surface of the modified silica gel particles, and then an antimicrobial peptide is grafted to obtain a modified medical silicone material, thereby improving the antibacterial properties of the silicone material and meeting the test performance requirements. The antibacterial medical silicone material prepared in Comparative Example 4 did not meet the performance requirements. This shows that the antibacterial medical silicone material prepared by the present invention not only has good antibacterial activity, but also has good biocompatibility, mechanical properties and thermal stability, which greatly improves the comprehensive performance of the medical silicone material and reduces its production cost.
[0083] In the description of the specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.
[0084] The above contents are merely examples and explanations of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the invention or exceed the scope defined by the claims, they shall all fall within the protection scope of the present invention.
Claims
1. An antibacterial medical silicone material, characterized in that: The method comprises the following raw materials in parts by weight: 80-100 parts of modified medical silicone material, 1-3 parts of antibacterial agent and 0.5-1 parts of vulcanizing agent; The modified medical silica gel material is prepared by grafting a copolymer of 4-vinylpyridine and acrylamide onto the surface of modified silica gel particles, and then grafting antimicrobial peptides; the modified silica gel particles are prepared by grafting γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane onto the surface of silica gel particles; and the antibacterial agent is prepared by coupling silver nanoparticles capped with polyvinylpyrrolidone with the surfaces of vancomycin and amikacin.
2. The antibacterial medical silicone material according to claim 1, characterized in that: The modified medical silica gel material comprises the following steps to prepare: A1: Modified silica gel particles are mixed with a copolymer of 4-vinylpyridine and acrylamide, and then azobisisobutyronitrile is added. After mixing evenly, the mixture is reacted at a constant temperature of 65°C for 7 hours under a nitrogen atmosphere. The mixture is filtered, extracted with toluene for 20 hours, and then washed with ethanol for 3 times. After drying under vacuum for 24 hours, modified silica gel particles grafted with the copolymer are obtained; A2: The copolymer-grafted modified silica gel particles were transferred to an activated antimicrobial peptide solution, reacted at room temperature for 2 hours, washed three times with deionized water and 4-hydroxyethylpiperazineethanesulfonic acid buffer, and then dried at 60°C for 1 hour to obtain a modified medical silica gel material.
3. The antibacterial medical silicone material according to claim 2, characterized in that: In step A1, the usage ratio of modified silica gel particles, copolymer of 4-vinylpyridine and acrylamide, azobisisobutyronitrile, toluene and ethanol is 2-3 g: 1-2 g: 30-40 mL: 20-30 mL: 25-30 mL.
4. The antibacterial medical silicone material according to claim 2, characterized in that: In step A2, the usage ratio of the copolymer-grafted modified silica gel particles, the antimicrobial peptide solution, the deionized water and the 4-hydroxyethylpiperazineethanesulfonic acid buffer is 1-2 g: 25-35 mL: 20-25 mL: 15-20 mL.
5. The antibacterial medical silicone material according to claim 2, characterized in that: In step A1, the modified silica gel particles are prepared by the following steps: Silica gel particles and a 5% methanesulfonic acid aqueous solution are mixed, stirred at 102°C for 4 hours, centrifuged, washed with deionized water for 3 times, and dried under vacuum for 24 hours. The mixture is added to ethanol, and γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane are added, and then deionized water is added. The mixture is reacted at 50°C in a nitrogen atmosphere for 24 hours, washed with ethanol and filtered, and dried under vacuum to obtain modified silica gel particles.
6. The antibacterial medical silicone material according to claim 5, characterized in that: The usage ratio of silica gel particles, methanesulfonic acid aqueous solution, deionized water, ethanol, γ-methacryloxypropyltrimethoxysilane and 3-aminopropyltrimethoxysilane is 1-2g:50-60mL:20-25mL:20-30mL:20-25mL:15-20mL.
7. The antibacterial medical silicone material according to claim 1, characterized in that: The antibacterial agent comprises the following steps: A 1 mol / L silver nitrate solution and a 2 mol / L sodium borohydride solution are mixed, polyvinyl pyrrolidone is added, and the mixture is continuously stirred in an ice bath until the solution changes to light yellow. Then, vancomycin and amikacin with a concentration of 0.1-0.5 mol / L are added to the mixed solution, and the mixture is magnetically stirred at room temperature for 15-20 minutes to obtain an antibacterial agent.
8. The antibacterial medical silicone material according to claim 7, characterized in that: The dosage ratio of silver nitrate solution, sodium borohydride solution, polyvinyl pyrrolidone, vancomycin and amikacin is 10-15mL:20-25mL:6-8mL:0.5-1mL:0.1-0.5mL.
9. The antibacterial medical silicone material according to claim 1, characterized in that: The vulcanizing agent is an A / B two-component platinum vulcanizing agent or a vulcanizing agent of double 25.
10. A method for preparing the antibacterial medical silicone material according to any one of claims 1 to 9, characterized in that: The following steps are involved: The modified medical silicone material and the vulcanizing agent are placed in a mixer, mixed evenly at room temperature, and then the antibacterial agent is added, and the mixing is continued evenly at room temperature, and then high-temperature vulcanization is performed at 120-170°C to finally obtain the antibacterial medical silicone material.