Hemostatic powder, production process, equipment and application

Abstract

The invention relates to the technical field of medical material preparation, in particular to styptic powder, a production process, equipment and application, the styptic powder comprises a mixing box, a cover plate and a stirring mechanism, the stirring mechanism comprises a first motor, a connecting shaft, a plurality of first stirring rods, a transmission assembly, an elliptical plate, a first sliding frame, a second sliding frame, a stress block, two pull rods and a first spring; the cover plate is provided with two sliding grooves, the first sliding frame and the second sliding frame are arranged in the two sliding grooves, one ends of the two pull rods are fixedly connected with the second sliding frame, the other ends of the two pull rods penetrate through the first sliding frame and are fixedly connected with the stress block, and the two ends of the first spring are fixedly connected with the first sliding frame and the second sliding frame respectively. In this way, the technical problem that in the prior art, the stirring and mixing effect on styptic powder of different batches or different components is poor, and then the preparation efficiency is affected is solved.

Description

Technical Field

[0001] The invention relates to the technical field of medical material preparation, and in particular to a hemostatic powder, a production process, equipment and application. Background Art

[0002] In the medical field, hemostatic powder, as an important first aid and surgical auxiliary material, is widely used in rapid hemostasis treatment of various bleeding situations. Traditional hemostatic powder preparation technology mostly relies on natural polymer materials such as gelatin, chitosan, etc., or synthetic polymer materials such as polyvinyl alcohol, fibrin glue, etc.; however, these materials often have problems such as high cost, complex process, limited biocompatibility or unsustainable resources during the preparation process.

[0003] With the development of technology, it is found that potato flour has gradually become an emerging raw material for the preparation of hemostatic powder due to its rich starch content, good biocompatibility and degradability. Potato starch can be properly modified to form a hemostatic material with good water absorption and adhesion, which can effectively promote blood coagulation and reduce bleeding time. When using potato flour to prepare hemostatic materials, a mixer is required to mix hemostatic powders of different batches or different components to ensure the uniformity and stability of the product.

[0004] However, the existing mixing equipment has poor effect in mixing hemostatic powders of different batches or different components, thereby affecting the preparation efficiency. Summary of the invention

[0005] The purpose of the present invention is to provide a hemostatic powder, a production process, an equipment and an application, aiming to solve the technical problem in the prior art that the mixing effect of hemostatic powders of different batches or different components is poor, thereby affecting the preparation efficiency.

[0006] To achieve the above-mentioned purpose, the present invention adopts a hemostatic powder production equipment, including a mixing box, a cover plate and a stirring mechanism, the cover plate is arranged on the mixing box, the stirring mechanism includes a first motor, a connecting shaft, a plurality of first stirring rods, a transmission assembly, an elliptical plate, a first sliding frame, a second sliding frame, a force block, two pull rods and a first spring, the cover plate has two slide grooves, the first sliding frame and the second sliding frame are both arranged in the two slide grooves, one end of the two pull rods are fixedly connected to the second sliding frame, the other ends of the two pull rods pass through the first sliding frame and are fixedly connected to the force block, the two ends of the first spring are respectively fixedly connected to the first sliding frame and the second sliding frame, the first motor is installed on the cover plate, the output end of the first motor is fixedly connected to the connecting shaft, the connecting shaft drives the elliptical plate to rotate through the transmission assembly, the elliptical plate is in contact with the force block and the first sliding frame, and the first sliding frame and the second sliding frame are both provided with a stirring assembly.

[0007] Wherein, the transmission assembly includes a driving wheel, a transmission belt, a driven wheel and a rotating rod, the rotating rod is rotatably connected to the cover plate, the driving wheel and the driven wheel are fixedly connected to the connecting shaft and the rotating rod respectively, and the transmission belt is arranged between the driving wheel and the driven wheel.

[0008] Among them, the stirring assembly includes a mounting plate, a second motor, a shaft and multiple second stirring rods, the mounting plate is provided on the first sliding frame and the second sliding frame, the second motor is installed on the corresponding mounting plate, the output end of the second motor is fixedly connected to the shaft, and the second stirring rod is fixedly connected to the shaft.

[0009] Wherein, the plurality of the first stirring rods and the plurality of the second stirring rods are distributed in an up-and-down staggered manner, and the first motor and the second motor rotate in opposite directions.

[0010] The present invention also provides a production process, which is applied to the hemostatic powder production equipment as described above, and is characterized in that:

[0011] The steps include:

[0012] Adding potato flour and water into a gelatinizer for gelatinization to obtain a gelatinized product;

[0013] The gelatinized starch emulsion is mixed with the oil phase by high-speed stirring and shearing force to form a stable emulsion, and a cross-linking agent is added during this process to cause a cross-linking reaction between starch molecules to form a hemostatic powder precursor with a network structure;

[0014] removing impurities and unreacted raw materials from the hemostatic powder precursor to obtain a relatively pure hemostatic powder precursor;

[0015] The purified hemostatic powder precursor is subjected to a refining treatment to obtain a refined hemostatic powder precursor;

[0016] The refined hemostatic powder precursor is dried, and then hemostatic powders of different batches or different components are mixed to obtain the hemostatic powder.

[0017] The gelatinized starch emulsion is mixed with the oil phase through high-speed stirring and shearing force to form a stable emulsion, and the cross-linking agent added in the process is epichlorohydrin.

[0018] In the process of removing impurities and unreacted raw materials from the hemostatic powder precursor, washing and suction filtration can be used.

[0019] Wherein, after the refined hemostatic powder precursor is dried and before mixing, the hemostatic powder should be sieved.

[0020] A hemostatic powder is prepared by adopting the hemostatic powder production process as described above.

[0021] The hemostatic powder as described above is used as a hemostatic material for stopping bleeding from trauma, bleeding from surgical wounds, and bleeding from oozing blood.

[0022] The hemostatic powder, production process, equipment and application of the present invention, when used specifically, first add potato flour and water into a gelatinizer for gelatinization to obtain a gelatinized product, mix the gelatinized starch emulsion with an oil phase through high-speed stirring and shearing force to form a stable emulsion, and add a cross-linking agent in this process to cause a cross-linking reaction between starch molecules to form a hemostatic powder precursor with a network structure, remove impurities and unreacted raw materials from the hemostatic powder precursor to obtain a relatively pure hemostatic powder precursor, refine the pure hemostatic powder precursor to obtain a refined hemostatic powder precursor, dry the refined hemostatic powder precursor, and then mix hemostatic powders of different batches or different components to obtain hemostatic powder. The specific method of mixing hemostatic powders of different batches or different components is: add hemostatic powders of different batches or different components into the mixing box, start the first motor and the two groups of the stirring components, the first motor drives the connecting The connecting shaft rotates, and the connecting shaft drives the multiple first stirring rods to rotate. The multiple first stirring rods and the two groups of stirring components stir and mix different batches or different components of hemostatic powder. At the same time, the connecting shaft drives the elliptical plate to rotate through the transmission assembly, and the elliptical plate drives the force block and the first sliding frame to move. The force block drives the second sliding frame to move through the two pull rods, and the first sliding frame and the second sliding frame drive the two groups of stirring components to move. After moving to the specified position, the elliptical plate continues to rotate and no longer resists the first sliding frame and the force block. At this time, the first spring drives the first sliding frame and the second sliding frame to reset, thereby repeatedly moving the two groups of stirring components to increase the range of action of the two groups of stirring components. In this way, the technical problem that the effect of stirring and mixing different batches or different components of hemostatic powder in the prior art is poor, thereby affecting the preparation efficiency is solved. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 It is a schematic structural diagram of the first embodiment of the present invention.

[0025] Figure 2 It is a partial structural diagram of the first embodiment of the present invention.

[0026] Figure 3 It is a schematic diagram of the partial structure of the first embodiment of the present invention.

[0027] Figure 4 The present invention Figure 3 AA line structural section view.

[0028] Figure 5 The present invention Figure 3 BB line structural cross-sectional view.

[0029] Figure 6 It is a schematic structural diagram of the second embodiment of the present invention.

[0030] 101-mixing box, 102-cover plate, 103-first motor, 104-connecting shaft, 105-first stirring rod, 106-elliptical plate, 107-first sliding frame, 108-second sliding frame, 109-force block, 110-pull rod, 111-first spring, 112-driving wheel, 113-transmission belt, 114-driven wheel, 115-rotating rod, 116-mounting plate, 117-second motor, 118-shaft body, 119-second stirring rod, 120-slide groove, 201-frame, 202-roller, 203-third motor, 204-cam, 205-guide rod, 206-block, 207-second spring. DETAILED DESCRIPTION

[0031] Embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but should not be construed as limiting the present invention.

[0032] The first embodiment of the present application is:

[0033] See also Figure 1 to Figure 5 ,in Figure 1 is a schematic structural diagram of a first embodiment of the present invention, Figure 2 is a partial structural diagram of the first embodiment of the present invention, Figure 3 is a partial structural diagram of the first embodiment of the present invention, Figure 4 The present invention Figure 3 AA line structural section view, Figure 5 The present invention Figure 3 BB line structural cross-sectional view.

[0034] The present invention provides a hemostatic powder production device, including a mixing box 101, a cover plate 102 and a stirring mechanism, wherein the stirring mechanism includes a first motor 103, a connecting shaft 104, a plurality of first stirring rods 105, a transmission assembly, an elliptical plate 106, a first sliding frame 107, a second sliding frame 108, a force block 109, two pull rods 110 and a first spring 111, the transmission assembly includes a driving wheel 112, a transmission belt 113, a driven wheel 114 and a rotating rod 115, and the stirring assembly includes a mounting plate 116, a second motor 117, a shaft 118 and a plurality of second stirring rods 119. The above scheme solves the technical problem in the prior art that the effect of stirring and mixing hemostatic powder of different batches or different components is poor, thereby affecting the preparation efficiency.

[0035] According to this specific embodiment, the cover plate 102 is disposed on the mixing box 101 , and the cover plate 102 is used to cover the mixing box 101 to prevent foreign matter from entering.

[0036] The cover plate 102 has two slide grooves 120, the first sliding frame 107 and the second sliding frame 108 are both arranged in the two slide grooves 120, one end of the two pull rods 110 are fixedly connected to the second sliding frame 108, the other ends of the two pull rods 110 pass through the first sliding frame 107, and are fixedly connected to the force block 109, the two ends of the first spring 111 are respectively fixedly connected to the first sliding frame 107 and the second sliding frame 108, the first motor 103 is installed on the cover plate 102, the output end of the first motor 103 is fixedly connected to the connecting shaft 104, and the connecting shaft 104 drives the elliptical plate 106 to rotate through the transmission assembly, The elliptical plates 106 are in contact with the force-bearing blocks 109 and the first sliding frame 107. The first sliding frame 107 and the second sliding frame 108 are both provided with stirring components. When in use, potato flour and water are first added into a gelatinizer for gelatinization to obtain a gelatinized product. The gelatinized product is mixed with the gelatinized starch emulsion and the oil phase by high-speed stirring and shearing force to form a stable emulsion. In this process, a cross-linking agent is added to cause a cross-linking reaction between starch molecules to form a hemostatic powder precursor with a network structure. Impurities and unreacted raw materials of the hemostatic powder precursor are removed to obtain a relatively pure hemostatic powder precursor. The pure hemostatic powder precursor is refined to obtain a refined hemostatic powder precursor. The refined hemostatic powder precursor is dried. After processing, different batches or different components of hemostatic powder are mixed to obtain hemostatic powder. The specific method of mixing different batches or different components of hemostatic powder is as follows: different batches or different components of hemostatic powder are added into the mixing box 101, and the first motor 103 and the two groups of the stirring components are started. The first motor 103 drives the connecting shaft 104 to rotate, and the connecting shaft 104 drives the plurality of the first stirring rods 105 to rotate. The plurality of the first stirring rods 105 and the two groups of the stirring components stir and mix the different batches or different components of hemostatic powder. At the same time, the connecting shaft 104 drives the elliptical plate 106 to rotate through the transmission component, and the elliptical plate 106 drives the force block 109 And the first sliding frame 107 moves, the force block 109 drives the second sliding frame 108 to move through the two pull rods 110, the first sliding frame 107 and the second sliding frame 108 drive the two groups of the stirring components to move, after moving to the specified position, the elliptical plate 106 continues to rotate and no longer resists the first sliding frame 107 and the force block 109, at this time the first spring 111 drives the first sliding frame 107 and the second sliding frame 108 to reset, thereby repeatedly making the two groups of the stirring components move to increase the range of action of the two groups of the stirring components, in this way solves the technical problem that the mixing effect of hemostatic powder of different batches or different components in the prior art is poor, thereby affecting the preparation efficiency.

[0037] Secondly, the rotating rod 115 is rotatably connected to the cover plate 102, the driving wheel 112 and the driven wheel 114 are fixedly connected to the connecting shaft 104 and the rotating rod 115 respectively, and the transmission belt 113 is arranged between the driving wheel 112 and the driven wheel 114. When in use, the connecting shaft 104 drives the driving wheel 112 to rotate, the driving wheel 112 drives the driven wheel 114 to rotate through the transmission belt 113, and the driven wheel 114 drives the rotating rod 115 to rotate.

[0038] Meanwhile, the first sliding frame 107 and the second sliding frame 108 are both provided with the mounting plate 116, the second motor 117 is mounted on the corresponding mounting plate 116, the output end of the second motor 117 is fixedly connected to the shaft 118, the second stirring rod 119 is fixedly connected to the shaft 118, and the second motor 117 is started, the output end of the second motor 117 drives the shaft 118 to rotate, the shaft 118 drives the plurality of second stirring rods 119 to rotate, and the plurality of second stirring rods 119 stir and mix different batches or different components of hemostatic powder;

[0039] The plurality of first stirring rods 105 and the plurality of second stirring rods 119 are arranged in an alternating manner up and down, and the first motor 103 and the second motor 117 rotate in opposite directions.

[0040] When using a hemostatic powder production device according to the present embodiment, potato flour and water are first added to a gelatinizer for gelatinization to obtain a gelatinized product. The gelatinized product is mixed with an oil phase by high-speed stirring and shearing force to form a stable emulsion. A cross-linking agent is added during this process to cause a cross-linking reaction between starch molecules to form a hemostatic powder precursor with a network structure. Impurities and unreacted raw materials in the hemostatic powder precursor are removed to obtain a relatively pure hemostatic powder precursor. The pure hemostatic powder precursor is refined to obtain a refined hemostatic powder precursor. The refined hemostatic powder precursor is dried, and then hemostatic powders of different batches or different components are mixed to obtain hemostatic powder. The specific method for mixing hemostatic powders of different batches or different components is as follows: hemostatic powders of different batches or different components are added to the mixing box 101, the first motor 103 and the two groups of the stirring components are started, the first motor 103 drives the connecting shaft 104 to rotate, and the connecting shaft 104 drives the plurality of the first stirring rods. 105 rotates, and the plurality of first stirring rods 105 and the two groups of stirring components stir and mix different batches or different components of hemostatic powder. At the same time, the connecting shaft 104 drives the elliptical plate 106 to rotate through the transmission assembly, and the elliptical plate 106 drives the force block 109 and the first sliding frame 107 to move. The force block 109 drives the second sliding frame 108 to move through the two pull rods 110, and the first sliding frame 107 and the second sliding frame 108 drive the two groups of stirring components to move. After moving to the specified position, the elliptical plate 106 continues to rotate and no longer resists the first sliding frame 107 and the force block 109. At this time, the first spring 111 drives the first sliding frame 107 and the second sliding frame 108 to reset, thereby repeatedly moving the two groups of stirring components to increase the range of action of the two groups of stirring components. In this way, the technical problem that the mixing effect of hemostatic powder of different batches or different components in the prior art is poor, thereby affecting the preparation efficiency, is solved.

[0041] The second embodiment of the present application is:

[0042] Based on the first embodiment, please refer to Figure 6 , Figure 6 It is a schematic structural diagram of the second embodiment of the present invention.

[0043] The present invention provides a hemostatic powder production device, which also includes a frame 201, two rollers 202, a third motor 203, a cam 204 and two sets of guide components, wherein the guide components include a guide rod 205, a block 206 and a second spring 207.

[0044] According to this specific embodiment, the mixing box 101 is arranged on the frame 201 through the guide assembly, the two rollers 202 are arranged on the mixing box 101, and the two rollers 202 are in contact with the frame 201, the third motor 203 is installed on the frame 201, and the output end of the third motor 203 is fixedly connected to the cam 204, and the cam 204 is in contact with the mixing box 101. By starting the third motor 203, the output end of the third motor 203 drives the cam 204 to rotate, and the cam 204 resists the mixing box 101 to move, and the stability of the mixing box 101 is improved by the guide assembly, and the cam 204 no longer resists the mixing box 101 after rotating to the specified position, and the mixing box 101 is driven to reset by the guide assembly, so as to repeatedly make the mixed inward materials shake, thereby further improving the mixing effect.

[0045] Among them, one end of the guide rod 205 is fixedly connected to the mixing box 101, the other end of the guide rod 205 passes through the frame 201 and is fixedly connected to the block 206, and the two ends of the second spring 207 are respectively fixedly connected to the frame 201 and the corresponding block 206. When the mixing box 101 moves, it drives the guide rod 205 to move, and the guide rod 205 slides on the frame 201 to guide and improve the stability of the mixing box 101.

[0046] When using a hemostatic powder production device according to the present embodiment, the third motor 203 is started, and the output end of the third motor 203 drives the cam 204 to rotate, and the cam 204 presses against the mixing box 101 to move, and the stability of the mixing box 101 is improved by the guide assembly. After the cam 204 rotates to a specified position, it no longer presses against the mixing box 101, and the mixing box 101 is reset by the guide assembly, thereby repeatedly shaking the mixed inward materials, and further improving the mixing effect.

[0047] The present invention also provides a production process, which is applied to the hemostatic powder production equipment as described above, and is characterized in that:

[0048] The steps include:

[0049] Adding potato flour and water into a gelatinizer for gelatinization to obtain a gelatinized product;

[0050] The gelatinized starch emulsion is mixed with the oil phase by high-speed stirring and shearing force to form a stable emulsion, and a cross-linking agent is added during this process to cause a cross-linking reaction between starch molecules to form a hemostatic powder precursor with a network structure;

[0051] removing impurities and unreacted raw materials from the hemostatic powder precursor to obtain a relatively pure hemostatic powder precursor;

[0052] The purified hemostatic powder precursor is subjected to a refining treatment to obtain a refined hemostatic powder precursor;

[0053] The refined hemostatic powder precursor is dried, and then hemostatic powders of different batches or different components are mixed to obtain the hemostatic powder.

[0054] The gelatinized starch emulsion is mixed with the oil phase through high-speed stirring and shearing force to form a stable emulsion, and the cross-linking agent added in the process is epichlorohydrin.

[0055] In the process of removing impurities and unreacted raw materials from the hemostatic powder precursor, washing and suction filtration can be used.

[0056] Wherein, after the refined hemostatic powder precursor is dried and before mixing, the hemostatic powder should be sieved.

[0057] The present invention also provides a hemostatic powder, which is prepared by adopting the hemostatic powder production process as described above.

[0058] The hemostatic powder as described above is used as a hemostatic material for stopping bleeding from trauma, bleeding from surgical wounds, and bleeding from oozing blood.

[0059] What is disclosed above is only a preferred embodiment of the present invention, and it certainly cannot be used to limit the scope of rights of the present invention. Ordinary technicians in this field can understand that all or part of the processes of the above embodiment and equivalent changes made according to the claims of the present invention still fall within the scope of the invention.

Claims

1. A hemostatic powder production device, comprising a mixing box and a cover plate, wherein the cover plate is arranged on the mixing box, characterized in that: Also includes a stirring mechanism; The stirring mechanism includes a first motor, a connecting shaft, a plurality of first stirring rods, a transmission assembly, an elliptical plate, a first sliding frame, a second sliding frame, a force block, two pull rods and a first spring, the cover plate has two slide grooves, the first sliding frame and the second sliding frame are both arranged in the two slide grooves, one end of the two pull rods are fixedly connected to the second sliding frame, the other ends of the two pull rods pass through the first sliding frame and are fixedly connected to the force block, the two ends of the first spring are respectively fixedly connected to the first sliding frame and the second sliding frame, the first motor is mounted on the cover plate, the output end of the first motor is fixedly connected to the connecting shaft, the connecting shaft drives the elliptical plate to rotate through the transmission assembly, the elliptical plate is in contact with the force block and the first sliding frame, and the first sliding frame and the second sliding frame are both provided with a stirring assembly.

2. The hemostatic powder production equipment according to claim 1, characterized in that: The transmission assembly includes a driving wheel, a transmission belt, a driven wheel and a rotating rod, the rotating rod is rotatably connected to the cover plate, the driving wheel and the driven wheel are fixedly connected to the connecting shaft and the rotating rod respectively, and the transmission belt is arranged between the driving wheel and the driven wheel.

3. The hemostatic powder production equipment according to claim 2, characterized in that: The stirring assembly includes a mounting plate, a second motor, a shaft and a plurality of second stirring rods. The mounting plate is provided on both the first sliding frame and the second sliding frame. The second motor is mounted on the corresponding mounting plate. The output end of the second motor is fixedly connected to the shaft, and the second stirring rod is fixedly connected to the shaft.

4. The hemostatic powder production equipment according to claim 3, characterized in that: The plurality of first stirring rods and the plurality of second stirring rods are distributed in an up-and-down staggered manner, and the first motor and the second motor rotate in opposite directions.

5. A production process, applied to the hemostatic powder production equipment as claimed in claim 4, characterized in that: The steps include: Adding potato flour and water into a gelatinizer for gelatinization to obtain a gelatinized product; The gelatinized starch emulsion is mixed with the oil phase by high-speed stirring and shearing force to form a stable emulsion, and a cross-linking agent is added during this process to cause a cross-linking reaction between starch molecules to form a hemostatic powder precursor with a network structure; removing impurities and unreacted raw materials from the hemostatic powder precursor to obtain a relatively pure hemostatic powder precursor; The purified hemostatic powder precursor is subjected to a refining treatment to obtain a refined hemostatic powder precursor; The refined hemostatic powder precursor is dried, and then hemostatic powders of different batches or different components are mixed to obtain the hemostatic powder.

6. The process for producing hemostatic powder according to claim 5, characterized in that: The gelatinized starch emulsion is mixed with the oil phase through high-speed stirring and shearing force to form a stable emulsion, and the cross-linking agent added in the process is epichlorohydrin.

7. The process for producing hemostatic powder according to claim 6, characterized in that: In the process of removing impurities and unreacted raw materials from the hemostatic powder precursor, washing and suction filtration can be used.

8. The process for producing hemostatic powder according to claim 7, characterized in that: After the refined hemostatic powder precursor is dried, the hemostatic powder should be sieved before mixing.

9. A hemostatic powder, prepared by the hemostatic powder production process according to claim 8.

10. Use of the hemostatic powder as claimed in claim 9 as a hemostatic material for hemostasis of traumatic bleeding, bleeding from surgical wounds, and oozing blood.

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