Ultrasonic stimulation system and method for improving sciatica under ultrasonic guidance

Abstract

The invention provides an ultrasonic stimulation system and method for improving sciatica under ultrasonic guidance, and belongs to the technical field of optics. According to the invention, original light field data is synthesized into event data for training a network, the event data is input into an event image reconstruction network module capable of converting continuous event streams into a series of intensity images to obtain light field event images, and then three-dimensional reconstruction of a target area is obtained through a three-dimensional image reconstruction network module. And a new technical reference is provided for solving the problem of how to improve the three-dimensional reconstruction quality and resolution of the light field microscope.

Description

Technical Field

[0001] The present invention belongs to the field of ultrasonic diagnosis and treatment technology, relates to the intersection of ultrasonic technology and control science and technology, and specifically relates to an ultrasonic stimulation system and method for improving sciatic nerve pain under ultrasound guidance. Background Art

[0002] Ultrasonic waves acting on human tissues will produce certain biological effects, such as mechanical effects, thermal effects, cavitation effects, etc. The ultrasonic vibrations generated when ultrasound propagates in the medium can cause the movement of substances in tissue cells. This unique therapeutic property of ultrasound is also called internal massage. It can change the permeability of cell membranes, stimulate the diffusion process of cell semipermeable membranes, promote metabolism, accelerate blood and lymph circulation, improve cell ischemia and hypoxia, improve tissue nutrition, change protein synthesis rate, improve regeneration function, etc., thereby changing the internal structure of cells, leading to changes in cell function, and extending and softening hard connective tissue. The mechanical effect of ultrasound can soften tissues, enhance permeability, promote metabolism and circulation, and stimulate the nervous system and cell function.

[0003] At present, the methods for relieving sciatica pain are divided into conservative treatment and surgical treatment. Conservative treatment generally includes taking medicine, local blockade (i.e., blocking injection), local massage or acupuncture. The present invention pioneered the use of ultrasound to relieve sciatica pain, and combined with a control algorithm to perform appropriate stimulation intensity. Medical experts at home and abroad have achieved very good results in the treatment of limb soft tissue injuries, limb chronic pain rehabilitation, and limb movement rehabilitation using ultrasound technology.

[0004] In the invention patent application document of publication number CN118304388A, a drug is disclosed for the therapeutic effect on the sciatic nerve. By constructing a sciatic nerve crush model mouse, behavioral, morphological and molecular biological tests were performed. The results showed that TAK1 kinase can promote the repair of damaged sciatic nerve myelin, promote motor balance ability, and has a positive therapeutic effect on peripheral nerve myelin damage diseases. And compared with wild-type model mice, TAK1 treatment promotes the regeneration and repair of sciatic nerve myelin in mice after crushing. In the invention patent application document of publication number CN118286357A, it is clarified that Tianma Uncaria granules have the effect of accelerating nerve regeneration and functional recovery after peripheral nerve injury, and the effective dose of this effect is 1.5g / kg of Tianma Uncaria granules. The present invention expands the scope of use of Tianma Uncaria granules and provides a theoretical basis for the application of Tianma Uncaria granules in the clinical treatment of peripheral nerve injury. In the invention patent application document of publication number CN117964700A, it is disclosed that the polypeptide can relieve the acute inflammatory pain induced by formalin in mice and the visceral pain induced by acetic acid, and can regulate the synaptic plasticity of the anterior cingulate cortex (ACC) of the mouse with neuropathic pain (spare nerve injury, SNI) of partial sciatic nerve ligation, thereby exerting analgesic and anti-anxiety effects. In the invention patent application document of publication number CN112494505A, the use of echinacoside (ECH) in the preparation of drugs for treating neuropathic pain is disclosed. The experimental results of the present invention show that when used within the safe dose range, the echinacoside at a dose of 200 mg / kg can significantly relieve the allodynia and hyperalgesia induced by the chronic constriction injury model of the sciatic nerve, improve the histopathological changes of the sciatic nerve and regulate the protein expression of inflammatory cytokines, proving that echinacoside has the effect of relieving the neuropathic pain caused by chronic constriction injury and promoting the recovery of nerve function. In the invention patent application document with publication number CN112043821A, it is confirmed that SJMHE1 polypeptide can significantly improve the recovery ability of sciatic nerve function in rats in peripheral nerve injury animal models, promote the regeneration of sciatic nerve, and have significant beneficial effects on the regeneration of sciatic nerve axons and the regeneration of sciatic nerve myelin sheath in rats. Drugs containing SJMHE1 polypeptide can treat peripheral nerve injury; at the same time, SJMHE1 polypeptide is a small molecule drug that is easier to absorb by the body and has no toxic side effects. Its sequence is known to facilitate standardized synthesis. Its application in the preparation of drugs for the treatment of peripheral nerve injury is of great significance to benefit patients and society. In the invention patent application document with publication number CN85105221, it is disclosed that the low-frequency alternating magnetic field and far-infrared thermal radiation generated by the coil field are used to treat human diseases, such as rheumatoid arthritis, lumbar muscle strain, scapulohumeral periarthritis, cervical spondylosis, sciatica, chronic gastritis, certain gynecological diseases, etc. The treatment is significant and has no side effects.Because of its simple manufacture, low price and easy mastery, it can be popularized to families for patients to use. At the same time, it can also be used as forest, geological and middle-aged and elderly health care applications. In the invention patent application document of publication number CN116963465A, an ultrasonic magnetic vibration heat therapy head and a therapy instrument are disclosed, which relate to the technical field of therapy equipment, including a housing, an electric therapy equipment, an air cooling device, an ultrasonic therapy equipment and a circulating cooling device. The present invention is provided by the coordination between the housing, the electric therapy equipment, the air cooling device, the ultrasonic therapy equipment and the circulating cooling device. When the user starts the electric therapy equipment for therapy, the air cooling device can be driven to rotate to suck the cold air in the external environment into the housing to cool the windward surface of the housing. At the same time, the circulating cooling device installed on the leeward surface of the housing can dissipate heat on the leeward surface of the housing by absorbing heat through state changes under the action of high temperature, so as to avoid the existing therapy head only dissipating heat to the therapy head through the heat sink installed on the therapy head, and the heat dissipation effect is poor, resulting in the therapy head being in a high temperature environment for a long time when working, which seriously affects the service life of the therapy head. In the invention application document of publication number CN113116296A, a photoacoustic and ultrasonic collaborative diagnosis and treatment system is disclosed, including: a photoacoustic monitoring device, an ultrasonic physiotherapy device and a controller; the photoacoustic monitoring device is used to send a laser signal to a target sample, and send a trigger signal to the controller while sending the laser signal to the target sample; the ultrasonic physiotherapy device includes an ultrasonic physiotherapy probe, which is used to send an ultrasonic excitation signal to the target sample according to the excitation mode parameters pre-stored by the controller; the controller is used to receive the trigger signal sent by the photoacoustic monitoring device, pre-store the excitation mode parameters of the ultrasonic physiotherapy device, receive the photoacoustic signal and the ultrasonic echo signal, and analyze the photoacoustic signal and the ultrasonic echo signal, wherein the photoacoustic signal is excited by the laser signal through the target sample, and the ultrasonic echo signal is generated by the ultrasonic excitation signal through the target sample. The present invention improves the safety of use and avoids secondary damage to damaged tissue.

[0005] The above cited patents are all systems that relieve nerve pain and damage in different ways, but there is no example of using ultrasound to relieve sciatic pain. Summary of the invention

[0006] In order to solve the problem that the current technology has not yet used ultrasound to de-tangle sciatic nerve pain, the present invention provides an ultrasound stimulation system and method for improving sciatic nerve pain under ultrasound guidance.

[0007] The technical solution of an ultrasound stimulation system and method for improving sciatic nerve pain under ultrasound guidance of the present invention is:

[0008] An ultrasonic stimulation system for improving sciatica pain under ultrasound guidance comprises a main control module, a signal output end of the main control module is sequentially connected to an amplification module, an ultrasonic transducer and a test object along the signal transmission direction, and also comprises an ultrasonic guidance device, the ultrasonic guidance device is connected to the input end of the main control module, and the ultrasonic guidance device is also connected to the test object for two-way signal transmission; wherein, a power supply for supplying power to the main control module, the amplification module and the transducer is arranged outside the main control module, the amplification module and the ultrasonic transducer.

[0009] A further improvement of the technical solution of the present invention is that the main control module sends out an initial signal to initially stimulate the test subject, then receives the signal fed back by the ultrasound guidance device and compares it with the initial signal, and adjusts the size of the signal to emit an accurate signal.

[0010] A further improvement of the technical solution of the present invention is that the amplification module includes a primary amplification module and a secondary amplification module, the primary amplification module is connected to the main control module, the signal transmitted by the main control module is first subjected to primary voltage amplification, and the secondary amplification module performs secondary amplification on the signal received from the primary amplification module.

[0011] A further improvement of the above technical solution of the present invention is that: the secondary amplification module is a power amplification module, which is used to convert the DC power obtained from the power supply into AC power.

[0012] A further improvement of the above technical solution of the present invention is that: the power supply provides a low voltage for the main control module and a high voltage for the amplification module, and a voltage conversion module for converting voltage exists inside the power supply.

[0013] A further improvement of the above technical solution of the present invention is that: the power supply is divided into a 12V voltage and a 5V voltage, the 12V voltage provides a DC voltage for the secondary amplification module, and the 5V voltage provides a voltage for the main control module; and the 12V voltage and the 5V voltage are converted through a DC-DC step-down circuit.

[0014] A further improvement of the technical solution of the present invention is that the ultrasonic transducer converts the electrical signal into an acoustic signal and is used to perform ultrasonic stimulation on the test subject.

[0015] A further improvement of the technical solution of the present invention is that the ultrasound guidance device is configured to locate the sciatic nerve of the test subject and determine the difference between the damaged sciatic nerve and the sciatic nerve in a normal healthy state, and then give the signal to the main control module. At the same time, the ultrasound guidance device is also used to feedback the signal at the test subject.

[0016] An ultrasound stimulation method for improving sciatic nerve pain under ultrasound guidance, using the above-mentioned ultrasound stimulation system, comprises the following steps:

[0017] S1. First, the accurate position of the sciatic nerve of the test subject is obtained according to the ultrasound guidance device, and then the main control module transmits an initial signal to perform initial ultrasound stimulation on the test subject;

[0018] S2, the ultrasound-guided device monitors the test subject in real time, and sets the duration of stimulation according to the initial signal emitted by S1. The ultrasound-guided device transmits the signal returned from the test subject to the main control module, and adjusts the emitted signal through the PID algorithm to adapt to the different positions and different pain levels of the test subject;

[0019] S3. Adjust the position of the ultrasonic transducer according to the signal obtained by the ultrasonic guidance device to achieve the optimal stimulation site.

[0020] Due to the adoption of the above technical solution, the technical advances achieved by the present invention include:

[0021] 1. The present invention provides an ultrasonic stimulation system and method for improving sciatic nerve pain under ultrasound guidance. The sciatic nerve is accurately positioned by an ultrasonic guidance device, and then the sciatic nerve is monitored in real time so that the main control module can adjust the position and intensity of the stimulation to achieve the optimal stimulation effect.

[0022] 2. The present invention innovatively proposes to use ultrasound as a method to relieve sciatic pain. Currently, the methods to relieve sciatic pain are divided into conservative treatment and surgical treatment. Conservative treatment is further divided into medication, massage and acupuncture, all of which can play a certain role in relief. Ultrasound acting on human tissue will produce certain biological effects, such as mechanical effect, thermal effect, cavitation effect, etc. Domestic and foreign medical experts have achieved very good results in the treatment of limb soft tissue injuries, limb chronic pain rehabilitation, and limb movement rehabilitation using ultrasound technology. Therefore, there is a certain scientific basis for using ultrasound on the sciatic nerve to relieve sciatic pain, and it is innovative.

[0023] 3. The present invention can be controlled by PID after power-on, and the stimulation intensity can be adjusted accordingly according to the signal fed back by the ultrasound guidance device to achieve the best stimulation effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the overall system framework of an ultrasonic stimulation system of an ultrasonic stimulation system and method for improving sciatic nerve pain under ultrasound guidance of the present invention;

[0025] Figure 2 It is a schematic diagram of the PID control system structure of an ultrasound stimulation system and method for improving sciatic nerve pain under ultrasound guidance of the present invention. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solution and advantages of the present invention more clear, the present invention is further described in detail below in combination with specific implementation methods and with reference to the accompanying drawings. In the following description, the description of the public structure and technology is omitted to avoid unnecessary confusion of the concept of the present invention.

[0027] First reference Figure 1 The ultrasonic stimulation system of the present invention includes a main control module, a signal output end of the main control module is connected to an amplification module, an ultrasonic transducer and a test object in sequence along the signal transmission direction, and also includes an ultrasonic guiding device, which is connected to the input end of the main control module and is also connected to the test object for two-way signal transmission.

[0028] The above-mentioned main control module controls the entire system. The main control module first sends out an initial signal to provide initial stimulation to the experimental subject, then receives the signal fed back by the ultrasound guidance device and compares it with the initial signal, and adjusts the size of the signal to emit an accurate signal. Its main function is to control the system to perform normal operation.

[0029] The above-mentioned amplification module amplifies the signal emitted by the signal source. The amplification module is divided into a primary amplification module and a secondary amplification module. The primary amplification module is a voltage amplification module, so that the signal obtained from the signal source is first subjected to a voltage amplification so as to meet the requirement of driving the secondary amplification circuit; the secondary amplification module is a power amplification module, so that the DC power obtained from the power supply is converted into AC power, which can meet the power requirements required by the subsequent ultrasonic transducer.

[0030] The ultrasonic transducer is used to convert the electrical signal in the amplification module into an acoustic signal, and transmit it to the test subject, thereby performing ultrasonic stimulation on the test subject.

[0031] The ultrasound guidance device in the present invention is configured to locate the sciatic nerve of the test subject and determine the difference between the damaged sciatic nerve and the sciatic nerve in a normal healthy state, and then send a signal to the main control module. At the same time, the ultrasound guidance device is also used to feedback the signal at the test subject.

[0032] In order to facilitate the power supply of the entire ultrasonic stimulation system in the present invention, continue to refer to Figure 1 The main control module, the amplifying module and the ultrasonic transducer are externally provided with a power supply for supplying power to the main control module, the amplifying module and the transducer. The power supply includes a 5V low voltage and a 12V high voltage. The 12V voltage and the 5V voltage are converted through a DC-DC step-down circuit, wherein the 5V voltage provides a low voltage for the main control module, and the 12V voltage provides a high voltage for the secondary amplifying module.

[0033] The method for using the ultrasonic stimulation system of the present invention is to first determine the specific position of the mouse's sciatic nerve through an ultrasonic guidance device, place the ultrasonic transducer at the position of the mouse's sciatic nerve through a coupling fluid, and the ultrasonic stimulation part emits an ultrasonic signal for the first time to ultrasonically stimulate the mouse's sciatic nerve.

[0034] After a period of stimulation, the ultrasound stimulation part adjusts the stimulation intensity according to the signal fed back by the ultrasound guidance device, and continues to stimulate the sciatic nerve of the mouse.

[0035] The ultrasound stimulation part adjusts the stimulation intensity according to the signal fed back by the ultrasound guidance device by adjusting the transmitted signal through the PID algorithm. Figure 2 shown.

[0036] Among them, the output variables of PID control are Kp, Ki, and Kd, where Kp, Ki, and Kd represent proportional control, integral control, and differential control, respectively. Proportional control is the basic control in PID control; integral control can eliminate steady-state errors, but may increase overshoot; differential control can speed up the response speed of the inertial system and reduce the overshoot trend.

[0037] Secondly, PID control is determined: according to the influence of PID control parameters on system performance and the adjustment principles of PID parameters at different stages of system dynamic response, and based on the parameter adjustment experience obtained from experiments, the PID control parameter adjustment principles that can enable the system to obtain the best response performance are obtained.

[0038] In the above embodiment, the present invention provides an ultrasonic stimulation system and method for improving sciatic nerve pain under ultrasound guidance, wherein the sciatic nerve is accurately positioned by an ultrasonic guidance device, and then the sciatic nerve is monitored in real time so that the main control module can adjust the position and intensity of the stimulation to achieve the optimal stimulation effect; at the same time, the present invention can be controlled by PID after power-on, and the stimulation intensity can be adjusted accordingly according to the signal fed back by the ultrasonic guidance device to achieve the optimal stimulation effect.

[0039] The above-described embodiments are merely descriptions of preferred implementations of the present invention, and are not intended to limit the concept and scope of the present invention. Without departing from the design concept of the present invention, various modifications and improvements made by ordinary persons in the art to the technical solution of the present invention should fall within the protection scope of the present invention, and the technical contents for which protection is sought in the present invention have been fully recorded in the claims.

Claims

1. An ultrasound stimulation system for improving sciatic nerve pain under ultrasound guidance, characterized in that: It includes a main control module, a signal output end of the main control module is connected to an amplifying module, an ultrasonic transducer and a test object in sequence along the signal transmission direction, and also includes an ultrasonic guiding device, which is connected to the input end of the main control module and is also connected to the test object for two-way signal transmission; wherein, a power supply for supplying power to the main control module, the amplifying module and the transducer is arranged outside the main control module, the amplifying module and the transducer.

2. The ultrasound stimulation system for improving sciatic nerve pain under ultrasound guidance according to claim 1, characterized in that: The main control module sends out an initial signal to initially stimulate the test subject, then receives a signal fed back by the ultrasound guidance device and compares it with the initial signal, and adjusts the size of the signal to emit an accurate signal.

3. The ultrasound stimulation system for improving sciatic nerve pain under ultrasound guidance according to claim 1, characterized in that: The amplification module includes a primary amplification module and a secondary amplification module. The primary amplification module is connected to the main control module to perform primary voltage amplification on the signal transmitted by the main control module, and the secondary amplification module performs secondary power amplification on the signal received from the primary amplification module.

4. The ultrasound stimulation system for improving sciatic nerve pain under ultrasound guidance according to claim 3, characterized in that: The secondary amplification module is a power amplification module, which is used to convert the DC power obtained from the power supply into AC power.

5. The ultrasound stimulation system for improving sciatic nerve pain under ultrasound guidance according to claim 4, characterized in that: The power supply provides a low voltage for the main control module and a high voltage for the amplification module, and a voltage conversion module for converting voltage exists inside the power supply.

6. The ultrasound stimulation system for improving sciatic nerve pain under ultrasound guidance according to claim 5, characterized in that: The power supply is divided into 12V voltage and 5V voltage, the 12V voltage provides a DC voltage for the secondary amplification module, and the 5V voltage provides a voltage for the main control module; and the 12V voltage and the 5V voltage are converted through a DC-DC step-down circuit.

7. The ultrasound stimulation system for improving sciatic nerve pain under ultrasound guidance according to claim 1, characterized in that: The ultrasonic transducer converts the electrical signal into an acoustic signal and is used to provide ultrasonic stimulation to the test subject.

8. The ultrasound stimulation system for improving sciatic nerve pain under ultrasound guidance according to claim 1, characterized in that: The ultrasound guidance device is configured to locate the sciatic nerve of the test subject and determine the difference between a damaged sciatic nerve and a sciatic nerve in a normal healthy state, and then send a signal to the main control module. The ultrasound guidance device is also used to feed back the signal at the test subject.

9. An ultrasound stimulation method for improving sciatic nerve pain under ultrasound guidance, characterized in that: Using any one of claims 1 to 8 of the ultrasonic stimulation system comprises the following steps: S1. First, the accurate position of the sciatic nerve of the test subject is obtained according to the ultrasound guidance device, and then the main control module transmits an initial signal to perform initial ultrasound stimulation on the test subject; S2, the ultrasound-guided device monitors the test subject in real time, and sets the duration of stimulation according to the initial signal emitted by S1. The ultrasound-guided device transmits the signal returned from the test subject to the main control module, and adjusts the emitted signal through the PID algorithm to adapt to the different positions and different pain levels of the test subject; S3. Adjust the position of the ultrasonic transducer according to the signal obtained by the ultrasonic guidance device to achieve the optimal stimulation site.

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