Micro-bubble generating device for syringe connection and use method of micro-bubble generating device

Abstract

The invention relates to a microbubble generating device for syringe connection and a using method, the microbubble generating device comprises a cylinder, a syringe connecting pipe is fixedly mounted at the top end of the cylinder, a microbubble discharging pipe is fixedly mounted at the bottom end of the cylinder, a flow deflector is fixedly mounted on the inner wall of the cylinder, two connecting rings are fixedly mounted in the cylinder, and a microbubble discharging pipe is fixedly mounted at the bottom end of the cylinder. And a Venturi effect pipeline is fixedly mounted between the two connecting rings. The invention aims to solve the problems of complicated operation, non-uniform microbubble generation and large operation resistance of the existing microbubble generation device, can realize stable and uniform microbubble generation on the premise of keeping a simple structure, ensures that the resistance is small in the whole operation process, meets the mechanical requirements of normal hand-push injection, and improves the production efficiency. Meanwhile, the survival time of the bubbles is prolonged through accurate release of the polysorbate 80 surfactant, and the device is designed to be disposable, so that cross infection is avoided, and the requirements for rapid and simple operation in clinical application are met.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a microbubble generating device for connecting with a syringe and a use method thereof. Background Art

[0002] In medical imaging technology, microbubble contrast agents are widely used in clinical examinations of cardiac ultrasound and other vascular imaging. Microbubble contrast agents vibrate under the action of ultrasound and scatter strong ultrasound signals. This is also the most important characteristic of microbubble contrast agents - enhancing backscattered signals. For example, in B-ultrasound, by injecting microbubble contrast agents into blood vessels, strong B-ultrasound echoes can be obtained, thereby showing the location and size of blood vessels more clearly on the image. Microbubble contrast agents can enhance the visualization of blood flow through the interaction between bubbles and ultrasound, providing clearer tissue structure and hemodynamic information.

[0003] Existing microbubble generation systems mainly rely on the combination of a three-way valve and a manual syringe to generate microbubbles by artificially mixing gas and liquid. The typical operation of this system is to repeatedly push and pull air and saline in the syringe to mix the liquid and gas to generate bubbles.

[0004] The prior art also has the following disadvantages:

[0005] 1) Poor bubble uniformity: The microbubbles generated by the traditional manual three-way valve mixing method are of different sizes, resulting in fluctuations in image quality and affecting the diagnostic imaging effect.

[0006] 2) Complex operation: Manual mixing requires medical staff to repeatedly push and pull the syringe, which is not only time-consuming, but also increases the difficulty of operation, affecting the efficiency and accuracy of use.

[0007] 3) Excessive resistance: The existing microbubble generation operation process has large resistance during the hand-pushing and pulling process. The operation requires the use of both hands to apply a large force, which increases operator fatigue. Especially in repetitive operations, it is easy to cause a burden on the user and is not suitable for fast and efficient clinical use.

[0008] 4) Short bubble survival time: Due to lack of surfactant control, microbubbles are easily dissipated or burst during the injection process, affecting the imaging effect and failing to meet the requirements of ultrasound image enhancement. Summary of the invention

[0009] In view of the shortcomings of the prior art, the present invention provides a microbubble generating device for syringe connection and a method of use, which has the advantages of stable and uniform production of microbubbles, low resistance during operation, and meets the mechanical requirements of normal hand-push injection. It solves the problems of complex operation, uneven generation of microbubbles, and high operation resistance in existing microbubble generating devices.

[0010] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a microbubble generating device for syringe connection, comprising a barrel, a syringe connecting tube is fixedly installed on the top of the barrel, a microbubble discharge tube is fixedly installed on the bottom of the barrel, a guide plate is fixedly installed on the inner wall of the barrel, two connecting rings are fixedly installed inside the barrel, a venturi effect pipe is fixedly installed between the two connecting rings, a gas cavity is formed between the venturi effect pipes, a one-way release mechanism is fixedly installed inside the barrel, a filter screen is fixedly installed inside the barrel, and a microbubble delivery port is opened at the bottom of the barrel;

[0011] The one-way release mechanism includes a mounting frame, the mounting frame is fixedly installed inside the cylinder, a polysorbate storage tube is fixedly installed inside the mounting frame, a feeding port is opened at the top and bottom of the polysorbate storage tube, a supporting frame is fixedly installed inside the polysorbate storage tube, an inner rod is movably installed inside the polysorbate storage tube, a first baffle is fixedly installed at the top end of the inner rod, and a second baffle is fixedly installed at the bottom end of the inner rod.

[0012] Furthermore, a sealing rubber ring is fixedly installed on the outer surface of the syringe connecting tube, and the guide plates are arranged in a ring shape with equal distances.

[0013] Furthermore, the two connecting rings are located below the guide plate, and the outer surfaces of the connecting rings are fixedly mounted with connecting plates arranged in an annular shape, and the connecting rings are fixedly mounted on the inner wall of the cylinder through the connecting plates.

[0014] Furthermore, the diameters of the upper and lower ends of the Venturi effect pipe are both larger than the diameter of the central pipe, and the one-way release mechanism is located below the Venturi effect pipe.

[0015] Furthermore, the filter screen is located below the one-way release mechanism, and the top end of the microbubble discharge pipe is fixedly installed inside the microbubble delivery port.

[0016] Furthermore, the polysorbate storage tube is filled with polysorbate active agent, and the support frame is located below the first baffle.

[0017] Furthermore, the diameter of the first baffle is equal to the inner diameter of the feeding port, and the diameter of the second baffle is greater than the inner diameter of the feeding port.

[0018] Furthermore, the polysorbate storage tube is located at a central position below the venturi effect pipe, and the outer surface of the filter screen is closely fitted to the inner wall of the cylinder.

[0019] A method for using a microbubble generating device for connection with a syringe, the method for using is specifically as follows:

[0020] Step 1: Connect the microbubble generator to the output end of the syringe, push the syringe, and the saline and air enter the interior of the cylinder through the syringe connecting tube. The guide plate disrupts the flow of the liquid to form turbulence, and the air mixes with the liquid through the gas cavity;

[0021] Step 2: After the liquid passes through the Venturi effect pipe, the liquid flow is further accelerated, the local pressure is reduced, and microbubbles of uniform size are formed.

[0022] Step 3: The polysorbate surfactant in the polysorbate storage tube is released into the mixing area through a one-way valve to stabilize the microbubbles and extend the life of the bubbles in the body;

[0023] Step 4: The generated microbubbles pass through the filter to filter out oversized or unqualified bubbles to ensure that the output microbubbles are uniform in size;

[0024] Step 5: The generated microbubbles are injected into the patient through the microbubble delivery port.

[0025] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0026] 1. The present invention aims to solve the problems of complex operation, uneven generation of microbubbles and high operation resistance in the existing microbubble generating devices. It can achieve stable and uniform microbubble generation while maintaining a simple structure, and ensure that the resistance of the entire operation process is small, which meets the mechanical requirements of normal hand-push injection. At the same time, the survival time of the bubbles is extended by the precise release of polysorbate 80 surfactant. The device is designed for single use to avoid cross infection and meet the needs of fast and easy operation in clinical applications.

[0027] 2. The present invention is a simple, controllable, disposable microbubble generating device, which can improve the generation efficiency and stability of microbubbles without increasing the complexity of the equipment and the difficulty of operation, thereby reducing the burden on medical staff. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is a schematic structural diagram of a microbubble generating device for syringe connection and a method of use of the present invention;

[0029] Figure 2 It is a front cross-sectional view of a microbubble generating device for syringe connection and a method of use of the present invention;

[0030] Figure 3 It is a front cross-sectional view of a one-way release mechanism of a microbubble generating device for syringe connection and a method of using the present invention;

[0031] Figure 4 A top view of a sectional view of a one-way release mechanism of a microbubble generating device for syringe connection and a method of use of the present invention.

[0032] In the figure: 1, cylinder; 2, syringe connecting tube; 3, microbubble discharge tube; 4, guide plate; 5, connecting ring; 6, Venturi effect pipe; 7, gas cavity; 8, one-way release mechanism; 801, mounting frame; 802, polysorbate 80 storage tube; 803, feeding port; 804, supporting frame; 805, inner rod; 806, first baffle; 807, second baffle; 9, filter screen; 10, microbubble delivery port. DETAILED DESCRIPTION

[0033] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] See also Figure 1-4 In this embodiment, a microbubble generating device for syringe connection includes a barrel 1, a syringe connecting tube 2 is fixedly installed on the top of the barrel 1, a microbubble discharge tube 3 is fixedly installed on the bottom of the barrel 1, a guide plate 4 is fixedly installed on the inner wall of the barrel 1, two connecting rings 5 ​​are fixedly installed inside the barrel 1, a venturi effect pipe 6 is fixedly installed between the two connecting rings 5, a gas cavity 7 is formed between the venturi effect pipes 6, a one-way release mechanism 8 is fixedly installed inside the barrel 1, a filter screen 9 is fixedly installed inside the barrel 1, and a microbubble delivery port 10 is opened at the bottom of the barrel 1;

[0035] The one-way release mechanism 8 includes a mounting frame 801, the mounting frame 801 is fixedly installed inside the cylinder 1, a polysorbate 80 storage tube 802 is fixedly installed inside the mounting frame 801, a feeding port 803 is provided at the top and bottom of the polysorbate 80 storage tube 802, a support frame 804 is fixedly installed inside the polysorbate 80 storage tube 802, an inner rod 805 is movably installed inside the polysorbate 80 storage tube 802, a first baffle 806 is fixedly installed at the top end of the inner rod 805, and a second baffle 807 is fixedly installed at the bottom end of the inner rod 805.

[0036] A method for using a microbubble generating device for syringe connection, the specific method of use is as follows:

[0037] Step 1: Connect the microbubble generator to the output end of the syringe, push the syringe, and the saline and air enter the interior of the cylinder 1 through the syringe connecting tube 2. The guide plate 4 disrupts the flow of the liquid to form turbulence, and the air mixes with the liquid through the gas cavity 7;

[0038] Step 2: After the liquid passes through the Venturi effect pipe 6, the liquid flow is further accelerated, the local pressure is reduced, and microbubbles of uniform size are formed.

[0039] Step 3: The polysorbate 80 surfactant in the polysorbate 80 storage tube 802 is released into the mixing area through the one-way valve to stabilize the microbubbles and extend the life of the bubbles in the body;

[0040] Step 4: The generated microbubbles pass through the filter 9 to filter out oversized or unqualified bubbles to ensure that the output microbubbles are uniform in size;

[0041] Step 5: The generated microbubbles are injected into the patient through the microbubble delivery port 10.

[0042] In this embodiment, a sealing rubber ring is installed on the outer surface of the syringe connecting tube 2. When the microbubble generating device is installed on the output end of the syringe, the syringe connecting tube 2 is inserted into the interior of the output end of the syringe and sealed with the sealing rubber ring to prevent liquid leakage.

[0043] In this embodiment, the guide vanes 4 are arranged in a circular shape at equal distances inside the cylinder 1 to form a turbulence generator. The turbulence generator is a device that disrupts the flow of liquid through the guide vanes 4 to form an irregular flow pattern. Turbulence can effectively promote the mixing of gas and liquid and is an important mechanism for generating uniform microbubbles.

[0044] In this embodiment, the connecting ring 5 is designed below the guide plate 4, and the outer surface of the connecting ring 5 is fixedly connected to the cylinder 1 through a connecting plate, so that the connecting ring 5 and the cylinder 1 do not contact each other to facilitate air flow. The Venturi effect pipe 6 is installed between the two connecting rings 5, and a Venturi effect is formed when the liquid passes through. The Venturi effect is that when the liquid passes through the contraction section in the pipe, the flow rate will increase and the pressure will decrease. This effect is used to accelerate the flow of liquid and generate negative pressure, promote gas-liquid mixing, and generate small and uniform bubbles.

[0045] In this embodiment, the filter screen 9 is designed below the one-way release mechanism 8 to filter out oversized or uneven bubbles, ensuring that the output bubbles are of uniform size and meet the requirements of clinical imaging.

[0046] In this embodiment, the support frame 804 is located below the first baffle 806, the diameter of the first baffle 806 is equal to the inner diameter of the feed port 803, the diameter of the second baffle 807 is greater than the inner diameter of the feed port 803, and a one-way control valve is formed inside the polysorbate 80 storage tube 802. When the airflow flows downward from the top, it will push the support frame 804 where the first baffle 806 moves downward to fit with it. At this time, the second baffle 807 will move downward, so that the polysorbate 80 storage tube 802 is opened and the polysorbate 80 surfactant is released. The airflow flows from the bottom to the top, which will push the second baffle 807 to move upward. The bottom of the polysorbate 80 storage tube 802 where the second baffle 807 moves will block the feed port 803, stop the release of the polysorbate 80 surfactant, and only allow liquid or gas to pass through the valve in one direction, which is used to control the release of the fluid under specific conditions. This design is used in the present invention to control the quantitative release of the surfactant and ensure the stability of microbubble generation.

[0047] In this embodiment, polysorbate 80 surfactant is commonly used as a stabilizer for bubble generation. It can reduce the surface tension of the gas-liquid interface, prolong the life of the bubble, and is widely used in the pharmaceutical and food industries.

[0048] In summary, the microbubble generating device for syringe connection is a simple, controllable, disposable microbubble generating device, which can improve the generation efficiency and stability of microbubbles without increasing the complexity of the equipment and the difficulty of operation, and reduce the burden on medical staff. It is intended to solve the problems of complex operation, uneven generation of microbubbles, and high operation resistance in existing microbubble generating devices. It can achieve stable and uniform microbubble generation while maintaining a simple structure, and ensure low resistance during the entire operation process, meeting the mechanical requirements of normal hand-push injection. At the same time, the survival time of the bubbles is extended by the precise release of the polysorbate 80 surfactant. The device is designed for disposable use to avoid cross infection and meet the needs of fast and easy operation in clinical applications.

[0049] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0050] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A microbubble generating device for syringe connection, comprising a barrel (1), characterized in that: A syringe connecting tube (2) is fixedly mounted on the top end of the barrel (1), a microbubble discharge tube (3) is fixedly mounted on the bottom end of the barrel (1), a guide plate (4) is fixedly mounted on the inner wall of the barrel (1), two connecting rings (5) are fixedly mounted inside the barrel (1), a venturi effect pipe (6) is fixedly mounted between the two connecting rings (5), a gas cavity (7) is formed between the venturi effect pipes (6), a one-way release mechanism (8) is fixedly mounted inside the barrel (1), a filter screen (9) is fixedly mounted inside the barrel (1), and a microbubble delivery port (10) is provided at the bottom of the barrel (1); The one-way release mechanism (8) comprises a mounting frame (801), the mounting frame (801) is fixedly mounted inside the cylinder (1), a polysorbate 80 storage tube (802) is fixedly mounted inside the mounting frame (801), a feeding port (803) is provided at the top and bottom of the polysorbate 80 storage tube (802), a supporting frame (804) is fixedly mounted inside the polysorbate 80 storage tube (802), an inner rod (805) is movably mounted inside the polysorbate 80 storage tube (802), a first baffle (806) is fixedly mounted at the top end of the inner rod (805), and a second baffle (807) is fixedly mounted at the bottom end of the inner rod (805).

2. A microbubble generating device for syringe connection according to claim 1, characterized in that: A sealing rubber ring is fixedly mounted on the outer surface of the syringe connecting tube (2), and the guide plates (4) are arranged in a ring shape at equal distances.

3. A microbubble generating device for syringe connection according to claim 1, characterized in that: The two connecting rings (5) are located below the guide plate (4), and the outer surface of the connecting ring (5) is fixedly mounted with connecting plates arranged in an annular pattern, and the connecting ring (5) is fixedly mounted on the inner wall of the cylinder (1) via the connecting plates.

4. A microbubble generating device for syringe connection according to claim 1, characterized in that: The diameters of the upper and lower ends of the Venturi effect pipe (6) are both larger than the diameter of the central pipe, and the one-way release mechanism (8) is located below the Venturi effect pipe (6).

5. The microbubble generating device for syringe connection according to claim 1, characterized in that: The filter screen (9) is located below the one-way release mechanism (8), and the top end of the microbubble discharge tube (3) is fixedly installed inside the microbubble delivery port (10).

6. The microbubble generating device for syringe connection according to claim 1, characterized in that: The polysorbate 80 storage tube (802) is filled with polysorbate 80 active agent, and the support frame (804) is located below the first baffle (806).

7. The microbubble generating device for syringe connection according to claim 1, characterized in that: The diameter of the first baffle (806) is equal to the inner diameter of the feeding port (803), and the diameter of the second baffle (807) is greater than the inner diameter of the feeding port (803).

8. The microbubble generating device for syringe connection according to claim 1, characterized in that: The polysorbate 80 storage tube (802) is located at a central position below the Venturi effect pipe (6), and the outer surface of the filter screen (9) is tightly fitted to the inner wall of the cylinder (1).

9. A method for using a microbubble generating device for connecting to a syringe, comprising the method for using a microbubble generating device for connecting to a syringe according to any one of claims 1 to 8, characterized in that: The usage is as follows: Step 1: Connect the microbubble generating device to the output end of the syringe, push the syringe, and the physiological saline and air enter the interior of the cylinder (1) through the syringe connecting tube (2). The guide plate (4) disrupts the flow of the liquid to form turbulence, and the air mixes with the liquid through the gas cavity (7); Step 2: After the liquid passes through the Venturi effect pipe (6), the liquid flow is further accelerated, the local pressure is reduced, and microbubbles of uniform size are formed; Step 3: The polysorbate 80 surfactant in the polysorbate 80 storage tube (802) is released into the mixing area through a one-way valve to stabilize the microbubbles and extend the life of the bubbles in the body; Step 4: The generated microbubbles pass through a filter (9) to filter out oversized or unqualified bubbles to ensure that the output microbubbles are uniform in size; Step 5: The generated microbubbles are injected into the patient's body through the microbubble delivery port (10).

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