Spine in-vitro simulation system

Abstract

The invention discloses a spinal column in-vitro simulation system, and belongs to the technical field of medical experiment devices, and the technical key points are that the spinal column in-vitro simulation system comprises an upper box body and a lower box body, the installation process is simpler through an arranged spinal column limiting mechanism, and adaptive installation limiting connection can be performed according to the height of a spinal column through an arranged lifting adjusting mechanism; through the arrangement of the limiting installation simulation avoidance mechanism, the butt joint of the limited and fixed spine upper installation seat and the spine in the lower box body below can be well realized, the disassembly treatment of the spine can also be realized, and through the arrangement of the load simulation mechanism, the simulation setting of the degree of freedom of the clamped spine can be well realized. The spinal column is arranged in the nutrient solution, so that the loaded condition of a living body in a physiological or pathological state can be better simulated, actions such as bending and stretching of the spinal column of the human body in different activities and postures can be well simulated, the motion state of the real spinal column can be more accurately simulated, and the spinal column simulation device has the advantages of being good in simulation effect and convenient to adjust and use.

Description

Technical Field

[0001] The invention relates to the field of medical experimental devices, in particular to an in vitro spinal simulation system. Background Art

[0002] The spine is an important part of the human body, located in the center of the back, extending from the base of the skull to the pelvis. It is composed of a series of vertebrae, intervertebral discs, ligaments, muscles and nerves, which provide support and protection for the body and participate in the movement and posture maintenance of the body. Human anatomy has conducted in-depth research on the structure and function of the spine, providing a basis for the diagnosis and treatment of spinal diseases.

[0003] The spine is an important supporting structure of the human body, and its stability and motor function are affected by biomechanical properties. Changes in biomechanical characteristics cause abnormal protein expression in tissues such as intervertebral discs, joint capsules, and ligaments, leading to pathological changes in these tissues. However, research on the mechanism by which biomechanical changes affect abnormal protein expression has been slow. The main reason is that the in vitro simulation system currently used is separated from the living body, cells die, and abnormal protein expression cannot be observed. The in vitro simulation systems on the market, such as robotic arms and six-dimensional spine test systems, are large in size and cannot be tested in an incubator. In addition, the specimens are exposed to the air, cell tissues are inactivated, and the simulation effect is poor, which cannot meet the needs of actual use.

[0004] Therefore, there is a need to provide an in vitro spinal simulation system to solve the above problems. Summary of the invention

[0005] In view of the deficiencies in the prior art, an embodiment of the present invention aims to provide an in vitro spine simulation system, aiming to solve the technical problems raised in the background technology.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] An in vitro simulation system of the spine comprises an upper box and a lower box, wherein the upper box is adapted to be sealed and installed to be connected to the lower box, and both the upper box and the lower box are made of transparent materials, an upper spine mounting seat for fixing one end of the spine is arranged in the upper box, and a lower spine mounting seat for fixing the other end of the spine is arranged in the lower box, the lower spine mounting seat is fixedly installed on a sealed lifting plate, and the sealed lifting plate is adapted to be sealed and slidably connected to the interior of the lower box, and further comprises:

[0008] A load simulation mechanism, which is installed on the upper box body and is used to simulate the load on the spine in each degree of freedom direction, and the load simulation mechanism includes a first telescopic rod and a second telescopic rod for simulating the extension and application of load, and a first electromagnet and a second electromagnet for load application and driving, the first telescopic rod and the second telescopic rod are both sealed and slidably connected to the upper box body through a sealing sleeve, and a connecting sleeve adapted to be connected to the first telescopic rod and the second telescopic rod is provided on the mounting seat on the spine;

[0009] A position limiting installation simulation avoidance mechanism is installed on the lower box body, and is used to release the elastic limit of the upper mounting seat of the spine to perform load simulation and dock the upper box body and the lower box body. The position limiting installation simulation avoidance mechanism includes a wedge-shaped push rod for releasing the limit of the upper mounting seat of the spine and a position limiting plug rod for position limiting installation connecting the upper box body and the lower box body. The limit plug rod is fixedly installed on the upper box body through the upper connecting seat, and the wedge-shaped push rod is fixedly installed on the lower box body through the lower connecting seat. A wedge-shaped block adapted to connect and drive the wedge-shaped push rod is movably installed on the upper connecting seat;

[0010] A spine limiting mechanism is installed on the outside of the lower spine mounting seat and is used to limit and fix the spine inserted into the lower spine mounting seat. The spine limiting mechanism includes a clamping rod for limiting the spine installation. The clamping rod is movably installed on the sealing lifting plate through a fixing seat. The lower spine mounting seat is provided with a avoiding groove for avoiding the connection of the clamping rod.

[0011] The lifting and lowering adjustment mechanism is installed at the internal connection between the sealing lifting plate and the lower box body, and is used for lifting and lowering adjustment and limiting according to the length of the spine.

[0012] As a further solution of the present invention, the load simulation mechanism also includes a first magnetic head adapted to be connected to the drive of the first electromagnet and a second magnetic head adapted to be connected to the drive of the second electromagnet, the first magnetic head is fixedly connected to one end of the first telescopic rod, and the first electromagnet is fixedly installed inside the upper connecting seat, the first telescopic rod is connected to the inside of the upper connecting seat by a guide slide plate with limited sliding, and the first magnetic head is arranged on one side of the first electromagnet, the second magnetic head is fixedly connected to one end of the second telescopic rod, and the second electromagnet is fixedly installed on the top of the upper box through the top connecting seat, and the second magnetic head is arranged on one side of the second electromagnet.

[0013] As a further solution of the present invention, the limit installation simulation avoidance mechanism also includes a first L-shaped connecting plate and a second L-shaped connecting plate for releasing the horizontal limit of the first telescopic rod on the spine mounting seat, the first L-shaped connecting plate being slidingly connected to the inside of the upper connecting seat by a second guide slide bar, and the second L-shaped connecting plate being slidingly connected to the inside of the upper connecting seat by a third guide slide bar, a first spring being provided on one side of the first L-shaped connecting plate, a first rotating gear being provided on the inner sides of the first L-shaped connecting plate and the second L-shaped connecting plate, and the first L-shaped connecting plate being provided on a side close to the guide slide bar, the first rotating gear being rotatably installed inside the upper connecting seat by a first connecting shaft, and teeth being meshed with the first rotating gear being provided on the first L-shaped connecting plate and the second L-shaped connecting plate, a wedge block being fixedly connected to the second L-shaped connecting plate, and the wedge block being slidingly connected to the outer side of the upper connecting seat by the first guide slide bar.

[0014] As a further solution of the present invention, the limit installation simulation avoidance mechanism also includes a limit rod for limit installation connected to the limit plug rod, the limit plug rod is provided with a limit groove adapted to be plugged into the limit rod, the limit rod is slidably connected to the interior of the lower connecting seat through a pull rod, and a second spring for resetting is provided on one side of the limit rod.

[0015] As a further solution of the present invention, the spine limiting mechanism also includes a second rotating gear and a double-sided toothed plate for driving the clamping rod to limit the spine. The clamping rod is rotatably installed inside the fixed seat through the second rotating gear. The second rotating gear is meshingly connected to the double-sided toothed plate. The double-sided toothed plate is limitedly and slidably connected to the inside of the fixed seat. A first screw rod is threadedly connected to the double-sided toothed plate, and the first screw rod is rotatably installed inside the fixed seat.

[0016] As a further solution of the present invention, the spine limiting mechanism also includes a worm and a first adjusting knob for driving the first screw to rotate, the first screw is connected to a second connecting shaft through the rotation of a first bevel gear pair, the second connecting shaft is rotatably installed inside a fixed seat, a worm wheel is fixedly connected to the second connecting shaft, a worm wheel is meshingly connected to the worm, the worm is rotatably installed on the fixed seat, one end of the worm is fixedly connected to the first adjusting knob, and an adjustment groove for avoiding the connection of the worm is opened on the lower box body.

[0017] As a further solution of the present invention, a clamping block for limiting the position of the spine is further provided in the spine mounting seat, and the clamping block is movably mounted inside the spine mounting seat via a third spring.

[0018] As a further solution of the present invention, the lifting and lowering adjustment mechanism includes a telescopic column and a fixed column for lifting drive, one end of the telescopic column is fixedly connected to the sealed lifting plate, one end of the fixed column is fixedly connected to the bottom of the lower box body, and the telescopic column is limitedly slidably connected to the inside of the fixed column, a second screw rod is threadedly connected to the telescopic column, the second screw rod is rotatably installed in the inside of the fixed column, the second screw rod is connected to a third connecting shaft through the rotation of a second bevel gear pair, and the third connecting shaft is rotatably installed on the fixed column.

[0019] As a further solution of the present invention, the lifting and adjusting mechanism also includes a fourth connecting shaft and a second adjusting knob for driving the third connecting shaft to rotate. The third connecting shaft is rotatably connected to the fourth connecting shaft through a synchronous belt. The fourth connecting shaft is rotatably installed on the lower box body through a fixed plate. One end of the fourth connecting shaft is fixedly connected to the second adjusting knob.

[0020] As a further solution of the present invention, the upper box body is provided with a liquid inlet pipe for adding culture solution, the upper box body is also provided with a liquid discharge pipe, and the top of the upper box body is provided with a handle for lifting.

[0021] In summary, compared with the prior art, the embodiments of the present invention have the following beneficial effects:

[0022] The spine limiting mechanism provided in the present invention makes the installation process more intuitive and simple, and the installation can be completed quickly without complicated tools and professional skills. The provided lifting and adjusting mechanism can adapt the installation limit connection according to the height of the spine, thereby saving a lot of time and labor costs. It not only improves work efficiency, but also reduces possible errors and rework during the installation process, and ensures its stability and safety.

[0023] By setting up a limit installation simulation avoidance mechanism, the limited and fixed upper spine mounting seat and the spine in the lower box below can be well connected, which is convenient for subsequent simulation experiments. At the same time, the clamping limit of the upper spine mounting seat can be released, which is convenient for realizing a simulation experiment on the freedom of the spine. The spine can also be disassembled without the use of complex tools or cumbersome steps, thereby greatly shortening the installation time and improving overall work efficiency.

[0024] The load simulation mechanism can be used to simulate the degrees of freedom of the clamped spine, so that the spine is placed in the nutrient solution to better simulate the loading conditions of a living body under physiological or pathological conditions. It can simulate the bending and extension of the spine in different activities and postures, and thus more accurately simulate the movement of the real spine. This provides a more realistic simulation environment for medical research and rehabilitation training, allowing medical professionals to develop personalized treatment plans and rehabilitation training based on the patient's specific conditions, thereby improving the treatment effect and the patient's recovery speed.

[0025] In order to more clearly illustrate the structural features and effects of the present invention, the present invention is described in detail below in conjunction with the accompanying drawings and specific embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a structural schematic diagram of an embodiment of the invention.

[0027] Figure 2 It is a side structural schematic diagram of an embodiment of the invention.

[0028] Figure 3 It is a schematic diagram of the structure in the open state in an embodiment of the invention.

[0029] Figure 4 It is a schematic diagram of the connection structure inside the upper box body in an embodiment of the invention.

[0030] Figure 5 It is a schematic diagram of the connection structure of the mounting seat on the spine in an embodiment of the invention.

[0031] Figure 6 It is a schematic diagram of the connection structure inside the lower box body in an embodiment of the invention.

[0032] Figure 7 It is a schematic diagram of the connection structure inside the upper connecting seat in an embodiment of the invention.

[0033] Figure 8 Schematic diagram of the connection structure of the wedge block in the embodiment of the invention.

[0034] Fig. 9 It is a schematic diagram of the connection structure inside the top connecting seat in an embodiment of the invention.

[0035] Fig.10 It is a schematic structural diagram of a cross-section of the lower connecting seat in an embodiment of the invention.

[0036] Fig.11 for Fig.10 Schematic diagram of the enlarged structure of A.

[0037] Fig.12 It is a schematic diagram of the connection structure of the lower spine mounting seat in an embodiment of the invention.

[0038] Fig.13 It is a schematic diagram of the side view structure of the interior of the lower box body in an embodiment of the invention.

[0039] Fig.14 It is a schematic diagram of the connection structure inside the fixing base in an embodiment of the invention.

[0040] Fig.15 for Fig.14 Schematic diagram of the enlarged structure of B.

[0041] Fig.16 It is a schematic diagram of the explosion structure of the sealed lifting plate connection in the embodiment of the invention.

[0042] Fig.17 It is a front structural schematic diagram of the internal connection of the lower box body in an embodiment of the invention.

[0043] Fig.18 for Fig.17 Schematic diagram of the enlarged structure of C in the figure.

[0044] Figure numerals: 1, upper box; 2, lower box; 3, drain pipe; 4, liquid inlet pipe; 5, adjustment slot; 6, handle; 7, upper spine mounting seat; 8, connecting sleeve; 9, lower spine mounting seat; 10, avoidance slot; 11, upper connecting seat; 12, limit plug rod; 13, limit slot; 14, first telescopic rod; 15, sealing sleeve; 16, first magnetic head; 17, first electromagnet; 18, guide slide; 19, first L-shaped connecting plate; 20, first rotating gear; 21, first connecting shaft; 22, second L-shaped connecting plate; 23, wedge block; 24, first guide slide bar; 25, second guide slide bar; 26, first spring; 27, third guide slide bar; 28, second electromagnet; 29, second magnetic head; 30, second telescopic rod; 31, lower connecting seat; 32, wedge-shaped push rod; 33, limit rod; 34, pull rod; 35, second spring; 36, sealing lifting plate; 37, clamping rod; 38, fixed seat; 39, second rotating gear; 40, double-sided toothed plate; 41, first screw rod; 42, first bevel gear pair; 43, second connecting shaft; 44, worm wheel; 45, worm; 46, first adjusting knob; 47, telescopic column; 48, fixed column; 49, second screw rod; 50, second bevel gear pair; 51, third connecting shaft; 52, synchronous belt; 53, fourth connecting shaft; 54, fixed plate; 55, second adjusting knob; 56, top connecting seat; 57, clamping block; 58, third spring. DETAILED DESCRIPTION

[0045] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0046] The specific implementation of the present invention is described in detail below in conjunction with specific embodiments.

[0047] Example 1

[0048] See also Figures 1 to 18 A spinal column in vitro simulation system, comprising an upper box body 1 and a lower box body 2, wherein the upper box body 1 is adapted to be sealed and installed to be connected to the lower box body 2, and both the upper box body 1 and the lower box body 2 are made of transparent materials, an upper spinal column mounting seat 7 for fixing one end of the spinal column is arranged in the upper box body 1, and a lower spinal column mounting seat 9 for fixing the other end of the spinal column is arranged in the lower box body 2, and the lower spinal column mounting seat 9 is fixedly installed on a sealing lifting plate 36, and the sealing lifting plate 36 is adapted to be sealed and slidably connected to the interior of the lower box body 2, and further comprising:

[0049] The spine limiting mechanism is installed on the outer side of the lower spine mounting seat 9 and is used to limit and fix the spine inserted into the lower spine mounting seat 9. The spine limiting mechanism includes a clamping rod 37 for limiting the spine installation. The clamping rod 37 is movably installed on the sealing lifting plate 36 through a fixing seat 38. The lower spine mounting seat 9 is provided with an avoidance groove 10 for avoiding the connection of the clamping rod 37.

[0050] The lifting and lowering adjustment mechanism is installed at the internal connection between the sealing lifting plate 36 and the lower box body 2, and is used to perform lifting and lowering adjustment and limit according to the length of the spine.

[0051] Furthermore, the spine limiting mechanism also includes a second rotating gear 39 and a double-sided toothed plate 40 for driving the clamping rod 37 to limit the spine. The clamping rod 37 is rotatably installed inside the fixed seat 38 through the second rotating gear 39. The second rotating gear 39 is meshingly connected to the double-sided toothed plate 40. The double-sided toothed plate 40 is limitedly slidably connected to the inside of the fixed seat 38. The double-sided toothed plate 40 is threadedly connected with a first screw rod 41, and the first screw rod 41 is rotatably installed inside the fixed seat 38.

[0052] Furthermore, the spine limiting mechanism also includes a worm 45 and a first adjusting knob 46 for driving the first screw 41 to rotate. The first screw 41 is connected to the second connecting shaft 43 through the rotation of the first bevel gear pair 42. The second connecting shaft 43 is rotatably installed inside the fixed seat 38. A worm wheel 44 is fixedly connected to the second connecting shaft 43. The worm wheel 44 is meshingly connected to the worm 45. The worm 45 is rotatably installed on the fixed seat 38. One end of the worm 45 is fixedly connected to the first adjusting knob 46, and an adjustment groove 5 for avoiding the connection of the worm 45 is opened on the lower box body 2.

[0053] Furthermore, the lifting and lowering adjustment mechanism includes a telescopic column 47 and a fixed column 48 for lifting drive, one end of the telescopic column 47 is fixedly connected to the sealing lifting plate 36, one end of the fixed column 48 is fixedly connected to the bottom of the lower box body 2, and the telescopic column 47 is limitedly slidably connected to the inside of the fixed column 48, and a second screw rod 49 is threadedly connected to the telescopic column 47, and the second screw rod 49 is rotatably installed in the inside of the fixed column 48. The second screw rod 49 is connected to the third connecting shaft 51 through the rotation of the second bevel gear pair 50, and the third connecting shaft 51 is rotatably installed on the fixed column 48.

[0054] Furthermore, the lifting and lowering adjustment mechanism also includes a fourth connecting shaft 53 and a second adjustment knob 55 for driving the third connecting shaft 51 to rotate. The third connecting shaft 51 is rotatably connected to the fourth connecting shaft 53 through a synchronous belt 52. The fourth connecting shaft 53 is rotatably installed on the lower box body 2 through a fixing plate 54. One end of the fourth connecting shaft 53 is fixedly connected to the second adjustment knob 55.

[0055] Furthermore, the upper box body 1 is provided with a liquid inlet pipe 4 for adding culture solution, the upper box body 1 is also provided with a liquid discharge pipe 3, and the top of the upper box body 1 is provided with a handle 6 for lifting.

[0056] Preferably, when conducting an in vitro simulation experiment of the spine, one end of the spine to be simulated is placed and plugged into the lower spine mounting seat 9, and the first adjusting knob 46 is adjusted and rotated to drive the worm 45 to rotate, and the second connecting shaft 43 is driven to rotate under the meshing connection between the worm 45 and the worm wheel 44, thereby driving the first screw rod 41 to rotate under the connection relationship of the first bevel gear pair 42, and because the first screw rod 41 is threadedly connected to the double-sided gear plate 40, the double-sided gear plate 40 is driven to move in the direction close to the first adjusting knob 46, so that under the meshing connection relationship between the second rotating gear 39 and the double-sided gear plate 40, the clamping rod 37 is brought close to each other to complete the limiting fixation of one end of the spine.

[0057] At this time, according to the height adjustment of the adaptive connection between the lower spine mounting seat 9 and the upper spine mounting seat 7 in the upper box body 1, the second adjusting knob 55 is rotated to drive the fourth connecting shaft 53 to rotate, thereby driving the third connecting shaft 51 to rotate under the synchronous driving action of the synchronous belt 52, and the third connecting shaft 51 drives the second screw rod 49 to rotate under the connection relationship of the second bevel gear pair 50, thereby driving the sealing lifting plate 36 to drive the lower spine mounting seat 9 to adjust in the height direction under the threaded connection relationship between the telescopic column 47 and the second screw rod 49, so that the adaptive installation limit connection can be performed according to the height of the spine.

[0058] It should be particularly noted that both the fourth connecting shaft 53 and the third connecting shaft 51 are provided with pulleys which are synchronously connected with the synchronous belt 52 .

[0059] Example 2

[0060] like Figures 1 to 11 As shown, on the basis of Example 1, this embodiment further includes a limit installation simulation avoidance mechanism, which is installed on the lower box body 2 and is used to release the elastic limit of the spine upper mounting seat 7 to perform load simulation and dock the limit installation of the upper box body 1 and the lower box body 2. The limit installation simulation avoidance mechanism includes a wedge-shaped push rod 32 for releasing the limit of the spine upper mounting seat 7 and a limit plug rod 12 for limit installation and connecting the upper box body 1 and the lower box body 2. The limit plug rod 12 is fixedly installed on the upper box body 1 through the upper connecting seat 11, and the wedge push rod 32 is fixedly installed on the lower box body 2 through the lower connecting seat 31. The upper connecting seat 11 is movably installed with a wedge block 23 that is adapted to be connected and driven by the wedge push rod 32.

[0061] Furthermore, the limited installation simulation avoidance mechanism also includes a first L-shaped connecting plate 19 and a second L-shaped connecting plate 22 for releasing the lateral limit of the first telescopic rod 14 on the spine mounting seat 7. The first L-shaped connecting plate 19 is limitedly slidably connected to the interior of the upper connecting seat 11 through a second guide slide bar 25, and the second L-shaped connecting plate 22 is limitedly slidably connected to the interior of the upper connecting seat 11 through a third guide slide bar 27. A first spring 26 is provided on one side of the first L-shaped connecting plate 19, and a first rotating gear 20 is provided on the inner sides of the first L-shaped connecting plate 19 and the second L-shaped connecting plate 22, and the first L-shaped connecting plate 19 is provided on a side close to the guide slide plate 18. The first rotating gear 20 is rotatably installed in the interior of the upper connecting seat 11 through a first connecting shaft 21, and the first L-shaped connecting plate 19 and the second L-shaped connecting plate 22 are both provided with teeth meshing with the first rotating gear 20. A wedge block 23 is fixedly connected to the second L-shaped connecting plate 22, and the wedge block 23 is limitedly slidably connected to the outer side of the upper connecting seat 11 through a first guide slide bar 24.

[0062] Furthermore, the limit installation simulation avoidance mechanism also includes a limit rod 33 for limit installation and connection to the limit plug rod 12, and the limit plug rod 12 is provided with a limit groove 13 adapted to be plugged with the limit rod 33. The limit rod 33 is connected to the interior of the lower connecting seat 31 by a pull rod 34 for limit sliding, and a second spring 35 for resetting is provided on one side of the limit rod 33.

[0063] Furthermore, a clamping block 57 for limiting the position of the spine is also provided in the spine mounting seat 7 . The clamping block 57 is movably mounted inside the spine mounting seat 7 via a third spring 58 .

[0064] Preferably, in the present embodiment, when the upper box body 1 has not yet been snapped and sealed with the lower box body 2, the spine mounting seat 7 in the upper box body 1 is limited and squeezed and fixed by the first telescopic rod 14 under normal conditions, mainly because the elastic squeezing of the second guide slide bar 25 in the upper connecting seat 11 causes the first L-shaped connecting plate 19 to move toward the side close to the guide slide plate 18, so that the guide slide plate 18 drives the first telescopic rod 14 to move toward the direction close to the spine mounting seat 7, so that the first telescopic rod 14 is clamped at the connecting sleeve 8 on the spine mounting seat 7, so that the spine mounting seat 7 can be clamped into the interior of the upper box body 1 under the limiting action of the four first telescopic rods 14 and is located at the center position of the upper box body 1, at this time, the spine mounting seat 7 that is limited and fixed can be well connected with the spine in the lower box body 2 below, and at this time, the docked spine can be elastically limited and clamped to the interior of the spine mounting seat 7 by the clamping block 57, thereby facilitating subsequent simulation experiments.

[0065] When the upper box body 1 and the lower box body 2 are docked and installed, a corresponding sealing ring is provided on the lower box body 2 for docking with the upper box body 1, thereby ensuring the sealing of the connection between the upper box body 1 and the lower box body 2. When the upper box body 1 is completely clamped on the lower box body 2, the wedge push rod 32 on the lower box body 2 is adapted to slide with the wedge block 23 on the upper connecting seat 11, so that the wedge push rod 32 pushes the wedge block 23 to move toward the first guide slide bar 24. At this time, under the rotational connection relationship of the first rotating gear 20, the first L-shaped connecting plate 19 can be driven to compress the first spring 26 to move away from the guide slide plate 18, so that the guide slide plate 18 is no longer limited by the first L-shaped connecting plate 19 on the side, thereby facilitating the subsequent control of the first electromagnet 17 for linear driving, thereby realizing the simulation experiment of the freedom of the spine.

[0066] In addition, when the upper box body 1 is fully connected to the lower box body 2, the limit rod 12 on the upper connecting seat 11 and the limit rod 33 on the lower connecting seat 31 are adapted to the sliding connection, so that the limit rod 33 is connected to the limit groove 13 on the limit rod 12, completing the docking limit between the upper box body 1 and the lower box body 2. When the upper box body 1 needs to be removed, it is only necessary to adjust the pull rod 34 to drive the limit rod 33 to move away from the limit rod 12. At this time, the upper box body 1 can be easily removed. It is convenient to use and can also realize the disassembly of the spine without the use of complex tools or cumbersome steps, thereby greatly shortening the installation time and improving the overall work efficiency.

[0067] Example 3

[0068] like Figures 1 to 9As shown, based on the above embodiments, this embodiment further includes a load simulation mechanism, which is installed on the upper box body 1 and is used to simulate the load on the spine in each degree of freedom direction. The load simulation mechanism includes a first telescopic rod 14 and a second telescopic rod 30 for simulating extension and load application, and a first electromagnet 17 and a second electromagnet 28 for load application drive. The first telescopic rod 14 and the second telescopic rod 30 are both sealed and slidably connected to the upper box body 1 through a sealing sleeve 15, and a connecting sleeve 8 that is adaptively connected to the first telescopic rod 14 and the second telescopic rod 30 is provided on the spine mounting seat 7.

[0069] Furthermore, the load simulation mechanism also includes a first magnetic head 16 adapted to be connected to the drive of the first electromagnet 17 and a second magnetic head 29 adapted to be connected to the drive of the second electromagnet 28, the first magnetic head 16 is fixedly connected to one end of the first telescopic rod 14, and the first electromagnet 17 is fixedly installed inside the upper connecting seat 11, the first telescopic rod 14 is connected to the inside of the upper connecting seat 11 by a guide slide 18 for limited sliding, and the first magnetic head 16 is arranged on one side of the first electromagnet 17, the second magnetic head 29 is fixedly connected to one end of the second telescopic rod 30, and the second electromagnet 28 is fixedly installed on the top of the upper box body 1 through the top connecting seat 56, and the second magnetic head 29 is arranged on one side of the second electromagnet 28.

[0070] Preferably, in the present embodiment, since the first L-shaped connecting plate 19 is away from the guide slide 18 and no longer limits the guide slide 18 when the upper box body 1 and the lower box body 2 are butt-jointed, the nutrient solution can be injected through the liquid inlet pipe 4 at this time, so that the mutual attraction or mutual repulsion between the first magnetic head 16 and the first electromagnet 17 can be achieved by controlling the positive and negative magnetic poles of the first electromagnet 17, that is, the telescopic control of the first telescopic rod 14 is achieved, and the mutual attraction or mutual repulsion between the second magnetic head 29 and the second electromagnet 28 can be achieved by controlling the positive and negative magnetic poles of the second electromagnet 28, that is, the telescopic control of the second telescopic rod 30 is achieved, thereby realizing a good simulation setting of the degree of freedom of the clamped spine, so that the spine is placed in the nutrient solution for better simulation of the loading conditions of a living body under physiological or pathological conditions.

[0071] The device can well simulate the bending and extension of the spine in different activities and postures of the human body, thereby more accurately simulating the movement state of the real spine, providing a more realistic simulation environment for medical research and rehabilitation training, so that medical professionals can develop personalized treatment plans and rehabilitation training according to the patient's specific situation, thereby improving the treatment effect and the patient's recovery speed.

[0072] Among them, it should be particularly noted that the structure of the spinal column fixation inside the device includes but is not limited to Teflon material. Teflon is a polymer obtained by polymerization of tetrafluoroethylene as a monomer, and has good heat resistance, cold resistance, acid resistance, alkali resistance, and strong stability.

[0073] It should be particularly noted that the components in this application are all universal standard parts or components well known to those skilled in the art, which effectively solve the technical problems raised in the background technology.

[0074] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An in vitro spinal simulation system, characterized in that: The invention comprises an upper box (1) and a lower box (2), wherein the upper box (1) is adapted to be sealed and installed on the lower box (2), and both the upper box (1) and the lower box (2) are made of transparent materials, an upper spine mounting seat (7) for fixing one end of the spine is arranged in the upper box (1), and a lower spine mounting seat (9) for fixing the other end of the spine is arranged in the lower box (2), and the lower spine mounting seat (9) is fixedly installed on a sealed lifting plate (36), and the sealed lifting plate (36) is adapted to be sealed and slidably connected to the interior of the lower box (2), and further comprises: A load simulation mechanism, which is installed on the upper box (1) and is used to simulate the load on the spine in each degree of freedom direction, the load simulation mechanism comprising a first telescopic rod (14) and a second telescopic rod (30) for simulating extension and load application, and a first electromagnet (17) and a second electromagnet (28) for load application and driving, the first telescopic rod (14) and the second telescopic rod (30) are both sealed and slidably connected to the upper box (1) through a sealing sleeve (15), and a connecting sleeve (8) is provided on the spine mounting seat (7) and is adaptively connected to the first telescopic rod (14) and the second telescopic rod (30); A position limiting installation simulation avoidance mechanism is installed on the lower box body (2) and is used to release the elastic limit of the spine upper mounting seat (7) to perform load simulation and dock the upper box body (1) and the lower box body (2) for position limiting installation. The position limiting installation simulation avoidance mechanism comprises a wedge-shaped push rod (32) for releasing the limit of the spine upper mounting seat (7) and a position limiting plug rod (12) for position limiting installation to connect the upper box body (1) and the lower box body (2). The position limiting plug rod (12) is fixedly installed on the upper box body (1) through an upper connecting seat (11), and the wedge-shaped push rod (32) is fixedly installed on the lower box body (2) through a lower connecting seat (31). A wedge-shaped block (23) adapted to be connected and driven by the wedge-shaped push rod (32) is movably installed on the upper connecting seat (11); A spine limiting mechanism is installed on the outside of the lower spine mounting seat (9) and is used to limit and fix the spine inserted into the lower spine mounting seat (9). The spine limiting mechanism includes a clamping rod (37) used for limiting the spine mounting. The clamping rod (37) is movably installed on the sealing lifting plate (36) through a fixing seat (38). The lower spine mounting seat (9) is provided with a avoiding groove (10) for avoiding the connection of the clamping rod (37). The lifting and lowering adjustment mechanism is installed at the internal connection between the sealing lifting plate (36) and the lower box body (2) and is used to perform lifting and lowering adjustment and limit according to the length of the spine.

2. The spinal column in vitro simulation system according to claim 1, characterized in that: The load simulation mechanism further comprises a first magnetic head (16) adapted to be connected to the first electromagnet (17) for driving and a second magnetic head (29) adapted to be connected to the second electromagnet (28) for driving, the first magnetic head (16) being fixedly connected to one end of the first telescopic rod (14), and the first electromagnet (17) being fixedly installed inside the upper connecting seat (11), the first telescopic rod (14) being limitedly slidably connected to the inside of the upper connecting seat (11) via a guide slide plate (18), and the first magnetic head (16) being arranged on one side of the first electromagnet (17), the second magnetic head (29) being fixedly connected to one end of the second telescopic rod (30), and the second electromagnet (28) being fixedly installed on the top of the upper box (1) via a top connecting seat (56), and the second magnetic head (29) being arranged on one side of the second electromagnet (28).

3. The spinal column in vitro simulation system according to claim 2, characterized in that: The limit installation simulation avoidance mechanism also includes a first L-shaped connecting plate (19) and a second L-shaped connecting plate (22) for releasing the first telescopic rod (14) from the lateral limit of the spine upper mounting seat (7); the first L-shaped connecting plate (19) is connected to the interior of the upper connecting seat (11) by a second guide slide bar (25) in a limit sliding manner; the second L-shaped connecting plate (22) is connected to the interior of the upper connecting seat (11) in a limit sliding manner by a third guide slide bar (27); a first spring (26) is provided on one side of the first L-shaped connecting plate (19); the first L-shaped connecting plate (19) and the second L-shaped connecting plate A first rotating gear (20) is arranged on the inner side of the upper connecting seat (22), and a first L-shaped connecting plate (19) is arranged on one side close to the guide slide plate (18), the first rotating gear (20) is rotatably installed inside the upper connecting seat (11) through a first connecting shaft (21), and the first L-shaped connecting plate (19) and the second L-shaped connecting plate (22) are both provided with teeth meshing with the first rotating gear (20), and a wedge block (23) is fixedly connected to the second L-shaped connecting plate (22), and the wedge block (23) is limitedly slidably connected to the outer side of the upper connecting seat (11) through a first guide slide bar (24).

4. The spinal column in vitro simulation system according to claim 3, characterized in that: The limit installation simulation avoidance mechanism also includes a limit rod (33) for limit installation and connection with the limit plug rod (12); the limit plug rod (12) is provided with a limit groove (13) adapted to be plugged with the limit rod (33); the limit rod (33) is connected to the interior of the lower connecting seat (31) by a pull rod (34) in a limit sliding manner; and a second spring (35) for resetting is provided on one side of the limit rod (33).

5. The spinal column in vitro simulation system according to claim 1, characterized in that: The spine limiting mechanism also includes a second rotating gear (39) and a double-sided toothed plate (40) for driving the clamping rod (37) to limit the spine. The clamping rod (37) is rotatably mounted inside the fixed seat (38) through the second rotating gear (39). The second rotating gear (39) is meshingly connected to the double-sided toothed plate (40). The double-sided toothed plate (40) is limitedly slidably connected to the inside of the fixed seat (38). A first screw rod (41) is threadedly connected to the double-sided toothed plate (40). The first screw rod (41) is rotatably mounted inside the fixed seat (38).

6. The spinal column in vitro simulation system according to claim 5, characterized in that: The spine limiting mechanism also includes a worm (45) and a first adjusting knob (46) for driving the first screw (41) to rotate; the first screw (41) is connected to a second connecting shaft (43) through the rotation of a first bevel gear pair (42); the second connecting shaft (43) is rotatably mounted inside a fixed seat (38); a worm wheel (44) is fixedly connected to the second connecting shaft (43); a worm (45) is meshingly connected to the worm wheel (44); the worm (45) is rotatably mounted on the fixed seat (38); one end of the worm (45) is fixedly connected to the first adjusting knob (46); and an adjusting groove (5) for avoiding the connection of the worm (45) is provided on the lower box body (2).

7. The spinal column in vitro simulation system according to claim 5, characterized in that: A clamping block (57) for limiting the position of the spine is also provided inside the spine mounting seat (7); the clamping block (57) is movably mounted inside the spine mounting seat (7) via a third spring (58).

8. The spinal column in vitro simulation system according to claim 1, characterized in that: The lifting and lowering adjustment mechanism comprises a telescopic column (47) and a fixed column (48) for lifting and lowering drive, one end of the telescopic column (47) is fixedly connected to the sealing lifting plate (36), one end of the fixed column (48) is fixedly connected to the bottom of the lower box body (2), and the telescopic column (47) is limitedly slidably connected to the inside of the fixed column (48), a second screw rod (49) is threadedly connected to the telescopic column (47), the second screw rod (49) is rotatably installed in the inside of the fixed column (48), the second screw rod (49) is connected to a third connecting shaft (51) through the rotation of a second bevel gear pair (50), and the third connecting shaft (51) is rotatably installed on the fixed column (48).

9. The spinal column in vitro simulation system according to claim 8, characterized in that: The lifting and lowering adjustment mechanism further comprises a fourth connecting shaft (53) for driving the third connecting shaft (51) to rotate and a second adjustment knob (55); the third connecting shaft (51) is rotationally connected to the fourth connecting shaft (53) via a synchronous belt (52); the fourth connecting shaft (53) is rotationally mounted on the lower box body (2) via a fixing plate (54); one end of the fourth connecting shaft (53) is fixedly connected to the second adjustment knob (55).

10. The spinal column in vitro simulation system according to claim 1, characterized in that: The upper box body (1) is provided with a liquid inlet pipe (4) for adding culture liquid, the upper box body (1) is also provided with a liquid discharge pipe (3), and the top of the upper box body (1) is provided with a handle (6) for lifting.

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