Febuxostat tablet detection equipment and detection method

Abstract

The invention discloses febuxostat tablet detection equipment and a detection method, and belongs to the technical field of medicine sampling detection equipment. The febuxostat tablet detection sampling device solves the problem that the detection result after sampling each time is affected due to the fact that the detection sampling mode after tabletting of febuxostat tablets at present is generally a manual sampling mode and the manual sampling has certain uncertainty. A tablet press is connected with a discharging mechanism and a discharging mechanism, bearing seats are symmetrically arranged on a base of a sampling inspection mechanism, a transmission shaft is rotationally installed on the bearing seats, a left-hand thread is machined on the left half portion of the transmission shaft, a right-hand thread is machined on the right half portion of the transmission shaft, and sliding blocks are connected to the left-hand thread and the right-hand thread. Each sliding block is connected with a sliding rail in a sliding manner, the sliding rails are symmetrically mounted on the base, a connecting seat is arranged on the base, a swing arm is hinged to each connecting seat, the swing arms are connected with guide blocks of the sliding blocks in a sliding manner, and the sampling hopper is hinged to the upper ends of the swing arms. According to the febuxostat tablet detection equipment, the accuracy degree of medicine detection and the medicine quality are improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of drug sampling and testing equipment, and specifically relates to a Febuxostat tablet testing device and a testing method. Background Art

[0002] The main function of Febuxostat tablets is to reduce the level of uric acid in the body and is commonly used to treat hyperuricemia and gout. The manufacturing process of Febuxostat tablets includes preparation of raw materials, crushing and screening, mixing of auxiliary materials, granulation, tableting, coating, drying and cooling, as well as inspection and packaging.

[0003] In the production process of different steps, it is necessary to regularly and quantitatively extract some samples for testing, so as to appropriately adjust the data of each process flow according to the test results and improve the quality of the drug. In the process of tableting of Febuxostat tablets, the granular drug is pressed into tablets by a tablet press. After the tablets are output to the designated position, a certain amount of tablets need to be regularly extracted for testing. The current extraction method is to manually select 10 to 15 tablets from the upper surface of the tablet pile every 15 to 20 minutes in the finished tablets, and then these sampled tablets are inspected for appearance, thickness and diameter, hardness, side view of disintegration time, content determination, dissolution test and microbial inspection to ensure the quality and efficacy of Febuxostat tablets through these inspections.

[0004] However, manually selecting tablets from a pile of finished tablets can only roughly indicate that these medicines are newly compressed tablets. However, there is a high probability of uncertainty in manual selection, so there is also a certain degree of uncertainty in the test results of Febuxostat tablets after compression.

[0005] Therefore, the present application proposes a Febuxostat tablet detection device and a detection method to solve the above problems. Summary of the invention

[0006] The purpose of the research and development of the present invention is to solve the problem that the current method of sampling after tableting of Febuxostat tablets is generally manual sampling, which has certain uncertainties, thereby affecting the problem of the test results after each sampling. A brief overview of the present invention is given below to provide a basic understanding of certain aspects of the present invention. It should be understood that this overview is not an exhaustive overview of the present invention. It is not intended to determine the key or important parts of the present invention, nor is it intended to limit the scope of the present invention.

[0007] The technical solution of the present invention:

[0008] Solution 1: A Febuxostat tablet testing device includes a tablet press, a discharging mechanism and a sampling mechanism. The input end of the tablet press is connected to the discharging mechanism, the output end of the tablet press is connected to the discharging mechanism, and the sampling mechanism is arranged below the discharging mechanism. The sampling mechanism includes a base, a slide rail, a slider, a transmission shaft, a swing arm, a sampling bucket, a connecting seat and a guide block. The base is symmetrically provided with bearing seats, the transmission shaft is rotatably mounted on the bearing seat, the left half of the transmission shaft is processed with a left-handed thread, and the right half of the transmission shaft is processed with a right-handed thread. Slide blocks are respectively connected to the left-handed thread and the right-handed thread, each slider is slidably connected to the slide rail, the slide rail is symmetrically installed on the base, and the base is also symmetrically provided with connecting seats, each connecting seat is hinged with a swing arm, the swing arm is slidably connected to the guide block of the slider, and the sampling bucket is hinged at the upper end of the swing arm.

[0009] Furthermore, the tablet press includes an upper punch, a lower punch, a feed tray, a feed tube, a turntable and a driving unit, the execution end of the driving unit is connected to the turntable, the lower punches are evenly distributed on the circumference of the turntable, an upper punch is arranged above each lower punch, the feed tray is installed on the turntable, a feed tube is arranged above the feed tray, the other end of the feed tube is connected to the feed mechanism, a discharge port is processed on the tablet press, and the discharge mechanism is arranged below the discharge port.

[0010] Furthermore, the discharging mechanism includes a discharging shell, a feed port, a rotating drum and auger blades. The discharging shell is installed on the side wall of the tablet press, and the rotating drum is rotatably arranged in the discharging shell. The motor execution end in the driving part passes through the tablet press and is connected to the rotating drum. The inner wall of the rotating drum is evenly distributed with auger blades. A feed port is processed on the discharging shell, and the feed port is arranged below the discharging port. The feed port is connected with the inside of the rotating drum.

[0011] Furthermore, a driven wheel is connected to the transmission shaft, the driven wheel is arranged between two bearing seats, the driven wheel is connected to the driving wheel through a belt, the driving wheel is connected to the execution end of the motor, and the motor is arranged on the outside of the sampling mechanism.

[0012] Furthermore, an articulated seat is provided on the swing arm, one end of the connecting rod is hinged to the articulated seat, the other end of the connecting rod is connected to the sliding support, the sliding support is slidably connected to the connecting seat, and the sliding support is arranged below the sampling bucket.

[0013] Furthermore, a guide groove is processed on the side wall of the sliding support, and a guide block is processed at a corresponding position of the connecting seat, and the guide block is slidably connected to the guide groove.

[0014] Furthermore, a spring mounting seat is provided on the side wall of the swing arm, and a spring mounting seat is provided at the bottom of the sampling bucket. One end of the connecting spring is connected to the spring mounting seat of the swing arm, and the other end of the connecting spring is connected to the spring mounting seat of the sampling bucket.

[0015] Solution 2: A method for detecting febuxostat tablets, which is implemented based on a febuxostat tablet detection device described in Solution 1, and comprises the following steps:

[0016] Step 1: The pre-processed pharmaceutical granules are put into the feeding tube of the tablet press through the feeding mechanism, and the motor in the driving part is turned on. The motor drives the turntable to rotate, and the pharmaceutical granules enter the lower punch through the feeding tube. The turntable rotates to make the upper punch and the lower punch compact the pharmaceutical granules into tablets;

[0017] Step 2: The compressed tablets are discharged through the discharge port and enter the drum from the feeding port of the discharge mechanism. The motor connected to the drum in the driving unit is turned on, and the drum rotates in the discharge housing. The auger blades arranged inside the drum transport the tablets forward and discharge them, thus completing the transportation of the tablets.

[0018] Step 3: Turn on the motor, the motor's execution end rotates forward, driving the driving wheel to rotate forward, and the driven wheel is driven to rotate through the belt. Under the rotation of the driven wheel, the transmission shaft is driven to rotate, and the lower half of the swing arm connected on both sides is driven to move outward at the same time. Under the action of the middle part of the swing arm being hinged with the connecting seat, the upper half of the swing arm moves toward the driven wheel side at the same time, until the sampling bucket of the upper half of the swing arm is located at the discharge of the drum, and the discharged tablets fall on the sampling bucket, completing the sampling;

[0019] Step 4: Control the execution end of the motor to reverse, drive the driving wheel to reverse, drive the driven wheel to reverse through the belt, and the driven wheel drives the transmission shaft to reverse, thereby driving the lower half of the swing arms connected on both sides to move synchronously toward the driven wheel side, and the upper half of the swing arms to move outward, move the sampling bucket away from under the discharge port of the rotating drum, take out the tablets in the sampling bucket and test them.

[0020] The present invention has the following beneficial effects:

[0021] The febuxostat tablet detection device of the present invention drives the sampling bucket on the swing arm to move synchronously inward or outward through the swing arm that swings left and right under the action of the sampling inspection mechanism. When the sampling bucket moves inward at the same time, the sampling bucket is arranged below the discharging mechanism to collect the tablets discharged by the discharging mechanism. When the sampling bucket moves outward at the same time, the sampling bucket gives way to the bottom of the discharging mechanism, and the discharging mechanism discharges the material normally. The medicines extracted from the sampling bucket each time are definitely freshly produced medicines, thereby improving the authority and accuracy of medicine detection, and further improving the quality of the medicines. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure of a Febuxostat tablet testing device;

[0023] Figure 2 is a front view of a febuxostat tablet testing device;

[0024] Figure 3 It is a schematic diagram of the sampling inspection agency;

[0025] Figure 4 It is a schematic diagram of the normal status of the sampling inspection agency;

[0026] Figure 5 It is a schematic diagram of the sampling process of the sampling inspection agency;

[0027] Figure 6 It is a schematic diagram of the swing arm of the sampling mechanism moving outward;

[0028] Figure 7 It is a schematic diagram of the discharging mechanism;

[0029] Figure 8 This is a schematic diagram of the normal state of the sampling inspection mechanism with a sliding support installed;

[0030] Fig. 9 It is a schematic diagram of the sampling process of the sampling inspection mechanism equipped with a sliding support;

[0031] Fig.10 It is a schematic diagram of the swing arm of the sampling mechanism equipped with a sliding support moving outward;

[0032] Fig.11 It is a schematic diagram of the positional relationship between the sliding support and the sampling bucket.

[0033] In the figure: 1-tablet press, 2-discharging mechanism, 3-sampling mechanism, 4-discharging mechanism, 5-discharging hopper, 11-upper punch, 12-lower punch, 13-discharging tray, 14-discharging tube, 15-turntable, 16-discharging port, 17-driving unit, 21-discharging shell, 22-feeding port, 23-rotating drum, 24-auger blade, 31-base, 32-slide rail, 33-slider, 34-motor, 35-driven wheel, 36-belt, 37-drive shaft, 38-driving wheel, 39-swing arm, 40-sampling hopper, 41-connecting seat, 42-guide block, 43-bearing seat, 44-connecting spring, 45-hinge seat, 46-connecting rod, 47-sliding support, 48-spring mounting seat, 49-guide groove, 50-guide block. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is described below by the specific embodiments shown in the accompanying drawings. However, it should be understood that these descriptions are only exemplary and are not intended to limit the scope of the present invention. In addition, in the following description, the description of well-known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present invention.

[0035] The connection mentioned in the present invention is divided into fixed connection and detachable connection. The fixed connection (i.e., non-detachable connection) includes but is not limited to conventional fixed connection methods such as folding connection, rivet connection, bonding connection and welding connection. The detachable connection includes but is not limited to conventional detachable methods such as threaded connection, snap connection, pin connection and hinge connection. When the specific connection method is not clearly defined, it is assumed that at least one connection method can always be found in the existing connection methods to achieve the function. Those skilled in the art can choose according to their needs. For example: welding connection is selected for fixed connection, and hinge connection is selected for detachable connection.

[0036] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0037] Embodiment 1, combination Figure 1-Figure 7 The present embodiment is described. A febuxostat tablet detection device of the present embodiment includes a tablet press 1, a discharging mechanism 2 and a sampling mechanism 3. The input end of the tablet press 1 is connected to a feeding mechanism 4, and the output end of the tablet press 1 is connected to the discharging mechanism 2. The sampling mechanism 3 is arranged below the discharging mechanism 2. The sampling mechanism 3 includes a base 31, a slide rail 32, a slider 33, a transmission shaft 37, a swing arm 39, a sampling bucket 40, a connecting seat 41 and a guide block 42. The base 31 is symmetrically provided with a bearing seat 43, and the transmission shaft 37 is rotatably mounted on the bearing seat 43, the left half of the transmission shaft 37 is processed with a left-handed thread, and the right half of the transmission shaft 37 is processed with a right-handed thread, the left-handed thread and the right-handed thread are respectively connected with sliders 33, each slider 33 is slidably connected to the slide rail 32, the slide rail 32 is symmetrically mounted on the base 31, and the base 31 is also symmetrically provided with connecting seats 41, each connecting seat 41 is hinged with a swing arm 39, the swing arm 39 is slidably connected to the guide block 42 of the slider 33, and the sampling bucket 40 is hinged at the upper end of the swing arm 39.

[0038] When preparing Febuxostat tablets, dry mixing is first performed, and the materials in the feed amount are added to the wet mixing granulator in the order of lactose, pregelatinized starch, Febuxostat and cross-linked sodium carboxymethyl cellulose, the stirring paddle speed is set to 100 rpm, the granulating knife speed is set to 1200 rpm, and the mixing time is 10 minutes; then the granulation process is performed, the adhesive is configured: 9 kg of hydroxypropyl cellulose is added to 18 kg of purified water and stirred until dissolved; liquid addition: the stirring paddle speed is set to 70 rpm, the granulating knife speed is 1000 rpm, the stirring is started, and the funnel valve is opened at the same time to start liquid addition, and 27 kg of hydroxypropyl cellulose aqueous solution is added to the wet granulator through the liquid addition hopper, and the addition is completed within 5 minutes. After the addition is completed, the stirring is stopped and the granulation process is started. Sequence: Granulation: The stirring blade speed is set to 90rpm, the granulating knife speed is 2800rpm, the time is set to 3min-5min, and the soft material is finished; Next, wet granulation: open the discharge port of the wet granulator, set the stirring speed to 40rpm, and sieve the wet soft material through the cone granulator 6mm×6mm for granulation. The granulation speed is set to 500rpm, and then the drying process is carried out: the granules after wet granulation are placed in the fluidized bed, the shaking bag operation time is 20s, the shaking bag interval time is 10s, the inlet temperature is set to 75℃±10℃, the fan speed is set to 2000rpm, and when the material temperature is close to 44℃, the moisture content of the granules is sampled and tested. When the moisture content of the granules does not exceed 3.0%, the drying is stopped and the moisture content of the final granules is tested. Then the dried granules are granulated through a 20-mesh nylon net of a swing granulator.

[0039] According to the yield of the granules after dry granulation, the amount of magnesium stearate added is converted (feeding amount = dry granule weight / 90.72×1.08), and the granules after granulation are transferred to the square cone mixer through the vacuum pipeline. The converted magnesium stearate is sucked into the square cone mixer through the vacuum pipeline along with the granules after granulation. The mixing speed is set to 6r / min, and the mixing is performed for 8 minutes. After the mixing is completed, samples are taken for intermediate granule testing; the granules after total mixing are placed in a turnover barrel lined with a medicinal polyethylene bag, and the bag mouth is tied; the properties are checked, and the content and moisture are tested. Enter the tableting process.

[0040] The tablet press 1 is an existing tablet press. The granular medicine is put into the tablet press through the feeding mechanism 4, enters the feeding tube 14 connected to the feeding mechanism 4, and finally discharged to the feeding tray 13 through the feeding tube 14. The turntable 15 of the tablet press 1 is driven to rotate by the motor in the bottom driving part 17 thereof. When the turntable 15 rotates, the granular medicine enters the lower punch 12 of the turntable 15 through the feeding tray 13, and the upper punch 11 presses down to compact the granular medicine to form tablets. The formed tablets are discharged into the discharge mechanism 2 through the discharge port 16. , falls into the drum 23 through the feeding port 22 processed on the discharge shell 21. The inner circumference of the drum 23 is evenly distributed with auger blades 24. The end of the drum 23 is connected to another motor in the driving part 17. When the motor is started, it drives the drum 23 to rotate in the discharge shell 21. As the drum 23 rotates, the finished tablets between the auger blades 24 are output. A lower hopper 5 is also installed on the discharge shell 21. The function of the lower hopper 5 is to ensure the output direction of the tablets and prevent the tablets from flying around.

[0041] According to the pharmaceutical process, the tablets formed by the tablet press need to be sampled every 5 to 10 minutes to measure the tablet weight (the range is ±5.0% of the tablet weight) and hardness (should be 4kg to 10kg). During the sample inspection, the motor 34 is turned on, and the motor 34 drives the driving wheel 38 to rotate. The driving wheel 38 drives the driven wheel 35 to rotate through the belt 36. The driven wheel 35 is installed on the transmission shaft 37, and the transmission shaft 37 is installed on the base 31 through the bearing seat 43. When the transmission shaft 37 rotates forward, the left and right sides of the transmission shaft 37 are respectively processed with reverse threads, and the threads on both sides are respectively threaded with sliders 33. The sliders 33 on each side are slidably installed on the base 31 through the slide rails 32. The side of the slider 33 A guide block 42 is provided on the wall, and the guide block 42 is slidably connected to the swing arm 39. The middle part of the swing arm 39 is hinged on the connecting seat 41, and the connecting seat 41 is installed on the base 31. Therefore, when the transmission shaft 37 rotates in the forward direction, the sliders 33 on both sides move outward synchronously, driving the lower half of the swing arm 39 to move outward. Under the action of the hinge connection between the swing arm 39 and the connecting seat 41, the upper halves of the swing arms 39 on both sides move toward the driven wheel 35 at the same time until they move to the bottom of the lower hopper 5. The tablets discharged from the lower hopper 5 fall into the sampling hopper 40 connected to the upper half of the swing arm 39, completing the sampling of the tablets. If the requirements are met for three consecutive times, the tablet weight (10 tablets are taken each time) and hardness (5 tablets are taken each time) can be measured every 30 minutes;

[0042] The two symmetrically arranged swing arms 39 have different heights, and the swing arm 39 on the left is higher than the swing arm 39 on the right. With this arrangement, the sampling buckets 40 on the two swing arms 39 will not interfere with each other, and the tablets in the two sampling buckets 40 with a height difference can also be checked for their appearance for comparison.

[0043] After sampling is completed, the control motor 34 is reversed, and the transmission shaft 37 is driven to reverse through the driving wheel 38, the belt 36 and the driven wheel 35, thereby driving the sliders 33 on both sides to move toward the driven wheel 35 at the same time, so that the lower half of the swing arm 39 moves toward the driven wheel 35, and then the upper half of the swing arm 39 drives the sampling bucket 40 to move outward, leaving the bottom of the lower hopper 5, and no longer extracting drug samples.

[0044] Embodiment 2, combined Figure 1 , Figure 8-Figure 11 The present embodiment is described. A Febuxostat tablet detection device of the present embodiment is different from the embodiment 1 in that a through hole is processed on the connecting seat 41, a hinge seat 45 is installed on the lower half of the swing arm 39, a connecting rod 46 is connected to the hinge seat 45, a sliding support 47 is installed on the other end of the connecting rod 46, and the sliding support 47 is slidably connected to the connecting seat 41 through the through hole of the connecting seat 41, a guide block 50 is processed on the inner wall of the through hole, and a guide groove 49 connected to the guide block 50 is processed on the side wall of the sliding support 47 to ensure that the sliding support 47 keeps moving vertically up and down during the sliding process. Under normal conditions, as shown in the attached Figure 8 shown.

[0045] When the motor 34 rotates forward and drives the transmission shaft 37 to rotate forward, the sliders 33 on both sides move outward synchronously, driving the lower half of the swing arm 39 to move outward, and the connecting rod 46 connected to the hinge seat 45 of the lower half of the swing arm 39 drives the sliding support 47 to move downward, and the upper half of the swing arm 39 moves to the bottom of the lower hopper 5 at the same time, and the sampling hopper 40 moves to the bottom of the lower hopper 5. The bottom of the sampling hopper 40 is connected to the connecting spring 44 through the spring mounting seat 48, and the other end of the connecting spring 44 is connected to the upper half of the swing arm 39 through another spring mounting seat 48. Under the support force of the connecting spring 44, the sampling hopper 40 maintains a horizontal state to prevent the hinge point between the sampling hopper 40 and the swing arm 39 from loosening, causing the sampling hopper 40 to tilt downward and cause the collected medicines to slide out of the sampling hopper 40, as shown in the attached figure. Fig. 9 shown.

[0046] When the motor 34 reverses and drives the transmission shaft 37 to reverse, the sliders 33 on both sides move toward the driven wheel 35 synchronously, driving the lower half of the swing arm 39 to move toward the driven wheel 35, and the connecting rod 46 connected to the hinge seat 45 of the lower half of the swing arm 39 drives the sliding support 47 to move upward, and the upper end surface of the sliding support 47 contacts the bottom of the sampling bucket 40 and pushes the sampling bucket 40 upward, and the connecting spring 44 connected to the bottom of the sampling bucket 40 and the upper half of the swing arm 39 is stretched, and the angle between the sampling bucket 40 and the swing arm 39 is greater than 90°. In this way, the other end of the sampling bucket 40 can be directly connected to the collection tube, and the other end of the collection tube can be directly connected to the detection equipment, such as a weighing scale, a hardness detection equipment or a disintegration detection equipment, etc. After the sampling bucket 40 is lifted up by the sliding support 47, the tablets are directly sent out, so that the tablets pressed out of the tablet press can be fully automatically detected, as shown in the attached figure. Fig.10 shown.

[0047] Embodiment 3, combined Figure 1-Figure 7 This embodiment describes a method for detecting a febuxostat tablet, comprising the following steps:

[0048] Step 1: The pre-processed pharmaceutical granules are put into the feeding tube 14 of the tablet press 1 through the feeding mechanism 4, and the motor in the driving part 17 is turned on. The motor drives the turntable 15 to rotate, and the pharmaceutical granules enter the lower punch 12 through the feeding tube 14. The turntable 15 rotates to make the upper punch 11 and the lower punch 12 compact the pharmaceutical granules into tablets;

[0049] Step 2: The compressed tablets are discharged through the discharge port 16 and enter the drum 23 through the feed port 22 of the discharge mechanism 2. The motor connected to the drum 23 in the drive unit 17 is turned on, and the drum 23 rotates in the discharge housing 21. The auger blades 24 provided inside the drum 23 transport the tablets forward and discharge them, thus completing the transportation of the tablets.

[0050] Step 3: Turn on the motor 34, the execution end of the motor 34 rotates forward, driving the driving wheel 38 to rotate forward, and driving the driven wheel 35 to rotate through the belt 36. Under the rotation of the driven wheel 35, the transmission shaft 37 is driven to rotate, and the lower half of the swing arm 39 connected on both sides thereof is driven to move outward at the same time. Under the action of the middle part of the swing arm 39 being hinged with the connecting seat 41, the upper half of the swing arm 39 moves toward the side of the driven wheel 35 at the same time, until the sampling bucket 40 of the upper half of the swing arm 39 is located at the discharge position of the rotating drum 23, and the discharged tablets fall on the sampling bucket 40, and the sampling is completed;

[0051] Step 4: Control the execution end of the motor 34 to reverse, drive the driving wheel 38 to reverse, drive the driven wheel 35 to reverse through the belt 36, and drive the transmission shaft 37 of the driven wheel 35 to reverse, thereby driving the lower half of the swing arms 39 connected on both sides to move synchronously toward the driven wheel 35 side, and the upper half of the swing arms 39 to move outward, and the sampling bucket 40 is moved away from under the discharge port of the rotating drum 23, and the tablets in the sampling bucket 40 are taken out and tested.

[0052] Embodiment 4, combined Figure 1-Figure 11 This embodiment describes a method for detecting a febuxostat tablet, comprising the following steps:

[0053] Step 1: The pre-processed pharmaceutical granules are put into the feeding tube 14 of the tablet press 1 through the feeding mechanism 4, and the motor in the driving part 17 is turned on. The motor drives the turntable 15 to rotate, and the pharmaceutical granules enter the lower punch 12 through the feeding tube 14. The turntable 15 rotates to make the upper punch 11 and the lower punch 12 compact the pharmaceutical granules into tablets;

[0054] Step 2: The compressed tablets are discharged through the discharge port 16 and enter the drum 23 through the feed port 22 of the discharge mechanism 2. The motor connected to the drum 23 in the drive unit 17 is turned on, and the drum 23 rotates in the discharge housing 21. The auger blades 24 provided inside the drum 23 transport the tablets forward and discharge them, thus completing the transportation of the tablets.

[0055] Step 3: Turn on the motor 34, the execution end of the motor 34 rotates forward, driving the driving wheel 38 to rotate forward, and driving the driven wheel 35 to rotate through the belt 36. Under the rotation of the driven wheel 35, the transmission shaft 37 is driven to rotate, and the lower half of the swing arm 39 connected on both sides thereof is driven to move outward at the same time. Under the action of the middle part of the swing arm 39 being hinged with the connecting seat 41, the upper half of the swing arm 39 moves toward the side of the driven wheel 35 at the same time, until the sampling bucket 40 of the upper half of the swing arm 39 is located at the discharge position of the rotating drum 23, and the discharged tablets fall on the sampling bucket 40, and the sampling is completed;

[0056] Step 4: Control the execution end of the motor 34 to reverse, drive the driving wheel 38 to reverse, drive the driven wheel 35 to reverse through the belt 36, and drive the transmission shaft 37 of the driven wheel 35 to reverse, thereby driving the lower half of the swing arms 39 connected on both sides to move synchronously toward the driven wheel 35 side, and the upper half of the swing arms 39 to move outward, and the sampling bucket 40 is moved away from under the discharge port of the rotating drum 23. The connecting rod 46 connected to the hinged seat 45 of the swing arm 39 drives the sliding support 47 to move upward, and the sliding support 47 is used to support the bottom of the sampling bucket 40 and push the sampling bucket 40 upward, connect a sampling tube to the sampling bucket 40, connect the other end of the sampling tube to the detection equipment, and output the tablets in the sampling bucket 40 to the detection equipment through the sampling tube.

[0057] This embodiment is only an exemplary description of the present invention and does not limit its protection scope. Those skilled in the art may also make partial changes thereto. As long as they do not exceed the spirit of the present invention, they are within the protection scope of the present invention.

Claims

1. A Febuxostat tablet testing device, characterized in that: The tablet press comprises a tablet press (1), a discharging mechanism (2) and a sampling mechanism (3), wherein the input end of the tablet press (1) is connected to a discharging mechanism (4), the output end of the tablet press (1) is connected to the discharging mechanism (2), the sampling mechanism (3) is arranged below the discharging mechanism (2), the sampling mechanism (3) comprises a base (31), a slide rail (32), a slide block (33), a transmission shaft (37), a swing arm (39), a sampling bucket (40), a connecting seat (41) and a guide block (42), the base (31) is symmetrically provided with a bearing seat (43), the transmission shaft (37) is rotatably mounted on the bearing seat (43), and the transmission shaft (37) is rotatably mounted on the bearing seat (43). On the seat (43), the left half of the transmission shaft (37) is processed with a left-handed thread, and the right half of the transmission shaft (37) is processed with a right-handed thread. The left-handed thread and the right-handed thread are respectively connected with sliders (33). Each slider (33) is slidably connected to a slide rail (32). The slide rail (32) is symmetrically installed on the base (31). The base (31) is also symmetrically provided with a connecting seat (41). Each connecting seat (41) is hinged with a swing arm (39). The swing arm (39) is slidably connected to a guide block (42) of the slider (33). The sampling bucket (40) is hinged at the upper end of the swing arm (39).

2. A Febuxostat tablet detection device according to claim 1, characterized in that: The tablet press (1) comprises an upper punch (11), a lower punch (12), a feed tray (13), a feed tube (14), a turntable (15) and a driving unit (17); the execution end of the driving unit (17) is connected to the turntable (15); the lower punches (12) are evenly distributed on the circumference of the turntable (15); an upper punch (11) is arranged above each lower punch (12); the feed tray (13) is mounted on the turntable (15); a feed tube (14) is arranged above the feed tray (13); the other end of the feed tube (14) is connected to a feed mechanism (4); a discharge port (16) is processed on the tablet press (1); and the discharge mechanism (2) is arranged below the discharge port (16).

3. A Febuxostat tablet detection device according to claim 2, characterized in that: The discharging mechanism (2) comprises a discharging housing (21), a feeding port (22), a rotating drum (23) and auger blades (24); the discharging housing (21) is mounted on the side wall of the tablet press (1); the rotating drum (23) is rotatably arranged in the discharging housing (21); the motor execution end in the driving unit (17) passes through the tablet press (1) and is connected to the rotating drum (23); the inner wall of the rotating drum (23) is evenly distributed with auger blades (24); the discharging housing (21) is processed with a feeding port (22); the feeding port (22) is arranged below the discharging port (16); and the feeding port (22) is communicated with the inside of the rotating drum (23).

4. A Febuxostat tablet detection device according to claim 3, characterized in that: The transmission shaft (37) is connected to a driven wheel (35), which is arranged between two bearing seats (43). The driven wheel (35) is connected to a driving wheel (38) via a belt (36), and the driving wheel (38) is connected to an execution end of a motor (34). The motor (34) is arranged outside the sampling mechanism (3).

5. A febuxostat tablet detection device according to claim 4, characterized in that: The swing arm (39) is provided with an articulated seat (45), one end of a connecting rod (46) is hinged to the articulated seat (45), the other end of the connecting rod (46) is connected to a sliding support (47), the sliding support (47) is slidably connected to the connecting seat (41), and the sliding support (47) is arranged below the sampling bucket (40).

6. A febuxostat tablet detection device according to claim 5, characterized in that: A guide groove (49) is processed on the side wall of the sliding support (47), and a guide block (50) is processed at a corresponding position of the connecting seat (41), and the guide block (50) is slidably connected to the guide groove (49).

7. A febuxostat tablet detection device according to claim 6, characterized in that: A spring mounting seat (48) is provided on the side wall of the swing arm (39), a spring mounting seat (48) is provided at the bottom of the sampling bucket (40), one end of the connecting spring (44) is connected to the spring mounting seat (48) of the swing arm (39), and the other end of the connecting spring (44) is connected to the spring mounting seat (48) of the sampling bucket (40).

8. A method for detecting febuxostat tablets, the method being implemented based on the febuxostat tablet detection device according to claim 7, characterized in that: The following steps are involved: Step 1: pre-processed pharmaceutical granules are fed into a feeding tube (14) of a tablet press (1) through a feeding mechanism (4), and the pharmaceutical granules enter a feeding tube (14) of the tablet press (1) through the feeding mechanism (4). The motor in a driving part (17) is turned on, and the motor drives a rotating disk (15) to rotate, and the pharmaceutical granules enter a lower punch (12) through the feeding tube (14). The rotating disk (15) rotates to cause an upper punch (11) and a lower punch (12) to compact the pharmaceutical granules into tablets. Step 2: The compressed tablets are discharged through the discharge port (16) and enter the rotating drum (23) through the feeding port (22) of the discharge mechanism (2). The motor connected to the rotating drum (23) in the driving unit (17) is turned on, and the rotating drum (23) rotates in the discharge housing (21). The tablets are transported forward and discharged through the auger blades (24) provided inside the rotating drum (23), thereby completing the transportation of the tablets. Step 3: Turn on the motor (34), the execution end of the motor (34) rotates forward, driving the driving wheel (38) to rotate forward, and driving the driven wheel (35) to rotate through the belt (36). Under the rotation of the driven wheel (35), the transmission shaft (37) is driven to rotate, driving the lower half of the swing arm (39) connected on both sides to move outward at the same time. Under the action of the middle part of the swing arm (39) being hinged with the connecting seat (41), the upper half of the swing arm (39) moves toward the driven wheel (35) at the same time until the sampling bucket (40) of the upper half of the swing arm (39) is located at the discharge position of the rotating drum (23), and the discharged tablets fall on the sampling bucket (40), completing the sampling; Step 4: Control the execution end of the motor (34) to reverse, drive the driving wheel (38) to reverse, drive the driven wheel (35) to reverse through the belt (36), and drive the transmission shaft (37) of the driven wheel (35) to reverse, thereby driving the lower half of the swing arm (39) connected on both sides to move synchronously toward the driven wheel (35), and the upper half of the swing arm (39) moves outward, and the sampling bucket (40) is moved away from the bottom of the discharge port of the rotating drum (23), and the tablets in the sampling bucket (40) are taken out and tested.

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