Soothing composition, application and cosmetic

Abstract

The invention belongs to the field of daily chemicals, and discloses a soothing composition which comprises carboxymethyl chitosan, water-soluble hydroxyphenyl propionamide benzoic acid and a plant extract, and the plant extract is a sophora flower extract and / or a salvia officinalis extract; the weight ratio of the carboxymethyl chitosan to the water-soluble hydroxyphenyl propionamide benzoic acid to the plant extract is (2-5): (2-5): (4-10). Through the combined action of the three components, the composition can play an effective soothing effect. The invention also aims to provide application of the soothing composition, and the soothing composition is used for preparing a soothing skin care product, so that the soothing effect of the skin care product is improved. Meanwhile, the invention further provides a cosmetic, and the cosmetic has an extremely strong soothing effect.

Description

Technical Field

[0001] The invention relates to the technical field of skin care, and in particular to a soothing composition, use and cosmetics. Background Art

[0002] The skin is prone to imbalance under long-term stress, and the stress mainly comes from the following three aspects:

[0003] (1) Environmental factors: seasonal changes, air pollution, changes in the surrounding environment, and ultraviolet intensity;

[0004] (2) Lifestyle: Excessive skin care, staying up late, unhealthy diet and other lifestyle habits can also cause skin sensitivity;

[0005] (3) Chemical substances: Irritating chemicals in daily cosmetics, hair dyes, detergents and other products can also induce skin sensitivity.

[0006] When the skin is in an unbalanced condition, it needs to be soothed and conditioned. Since modern people's lifestyles are more likely to cause unbalanced skin conditions, soothing skin care products occupy a large proportion in the skin care industry. Soothing skin care compositions and skin care products have always been the research and development focus of the skin care industry.

[0007] Skin soothing is mainly achieved through three aspects: sedation, anti-inflammatory relief, and reducing nerve sensitivity.

[0008] The technical problem to be solved by this application is: how to prepare a product with better allergy-relieving effect.

[0009] The combination of carboxymethyl chitosan and hydroxyphenylpropionamide benzoic acid (hydroxyphenylpropionamide benzoic acid) has been proposed in the market. The applicant has found through computer simulation and actual verification that these two have certain anti-allergic effects;

[0010] The anti-allergic mechanism of these two is as follows: carboxymethyl chitosan has excellent biological efficacy and is the only cationic biopolysaccharide. It is effective in anti-inflammatory, removing redness, repairing skin barrier, and relieving itching, and its efficacy has multiple pathways; hydroxyphenylpropionamide benzoic acid is a potent non-steroidal anti-inflammatory and antipruritic natural ingredient with multifunctional anti-inflammatory activity and antipruritic properties, reducing skin damage induced by free radicals; the specific mechanism can be seen in publication number CN116421513A, the subject of which is a patent application for a skin care composition with redness-relief and repairing effects on sensitive skin and a preparation method thereof.

[0011] The program also introduces kava extract, which has instant sedative, anti-inflammatory, antibacterial, antipruritic and moisturizing effects.

[0012] Through the experimental case records of this program, it can be found that when any one of the above three is missing, the soothing effect will be reduced.

[0013] Therefore, the technical problem to be solved by the present invention is: how to find a soothing composition that can promote the synergistic effect of carboxymethyl deacetylated chitosan and skin sensitivity regulator 4-tert-butyl cyclohexanol or plant extract, thereby enhancing the soothing effect of the composition. Summary of the invention

[0014] One of the objects of the present invention is to provide a soothing composition, which contains carboxymethyl chitosan, water-soluble hydroxyphenylpropionamide benzoic acid and Sophora japonica extract and / or sage extract. The cationic properties, anti-inflammatory and barrier repair functions of carboxymethyl chitosan, the anti-inflammatory and antipruritic properties of water-soluble hydroxyphenylpropionamide benzoic acid, and the plant phenols with anti-inflammatory and a certain degree of soothing properties contained in Sophora japonica extract and sage extract, the above three work together to achieve an effective soothing effect.

[0015] Another object of the present invention is to provide a use of a soothing composition for preparing a soothing skin care product, thereby improving the soothing effect of the skin care product.

[0016] At the same time, the invention also provides a skin care product with extremely strong soothing effect.

[0017] To achieve the above object, the present invention provides a soothing composition, comprising carboxymethyl chitosan, water-soluble hydroxyphenylpropionamide benzoic acid and a plant extract, wherein the plant extract is a Sophora japonica extract and / or a Sage extract;

[0018] The weight ratio of the carboxymethyl chitosan, the water-soluble hydroxyphenylpropionamide benzoic acid and the plant extract is 2-5:2-5:4-10.

[0019] Carboxymethyl chitosan not only has anti-inflammatory and soothing effects on the skin (refer to "Application Research of Low Molecular Weight Carboxymethyl Chitosan"), as a polysaccharide with a structure similar to ceramide, an important component of the human epidermal lipid membrane, it has excellent film-forming properties and can have a strong moisturizing effect, thereby improving the soothing effect of carboxymethyl chitosan itself; in other reports, it has been confirmed that its anti-inflammatory channel is mainly through inhibiting the production of cytokines IL-6 and TNF-α by induced macrophages;

[0020] Hydroxyphenylpropionamide benzoic acid inhibits NK1R activity, reduces MC degranulation, and inhibits the release of IL-6 by keratinocytes and macrophages, thereby achieving soothing, anti-inflammatory, and antipruritic effects; in other reports, it is also reported that hydroxyphenylpropionamide benzoic acid can inhibit the activity of transcription factor NF-kB to achieve the purpose of controlling redness;

[0021] Sophora japonica extract and sage extract both contain plant phenols that have anti-inflammatory and soothing properties to a certain extent;

[0022] All three have common anti-inflammatory and soothing functions. When used in combination, they combine their soothing functions from different anti-inflammatory pathways to achieve control of skin inflammation and film formation and moisture retention on the skin surface, achieving a mild anti-inflammatory effect and repair of the skin barrier.

[0023] In the soothing composition, the weight ratio of the carboxymethyl chitosan, the water-soluble hydroxyphenylpropionamide benzoic acid and the plant extract is 2-4:2-4:5-9.

[0024] Preferably, the weight ratio of the carboxymethyl chitosan, the water-soluble hydroxyphenylpropionamide benzoic acid and the plant extract is 2-3:2-3:5-8.

[0025] In the above soothing composition, the plant extracts are Sophora japonica extract and Sage extract;

[0026] The weight ratio of the Sophora japonica extract to the Sage extract is 3-7:1-3.

[0027] In further research of the present invention, it was found that when the two are used in a certain ratio and a large amount of Sophora japonica extract is used, the soothing effect can be effectively improved.

[0028] We believe that the fundamental reason is that the anti-inflammatory activity of Sophora japonica extract is better than that of Sage extract, but one of the active ingredients in Sage extract is luteolin, which has been proven to have anti-aging effects in some literature ("Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice", Nature Aging, July 2024). When it acts on the composition of the present invention, it inhibits macrophage phosphorylation, inhibits the activity of transcription factor NF-kB, and can inhibit lipopolysaccharide-induced macrophage induced cytokine activity; this action channel is significantly related to tingling and redness, and has a similar action channel with hydroxyphenylpropionamide benzoic acid, which can be superimposed to increase the efficacy of hydroxyphenylpropionamide benzoic acid. Therefore, on the basis of maintaining Sophora japonica extract as the main anti-inflammatory component, the auxiliary sage extract with anti-inflammatory function and strong soothing function can significantly enhance the anti-inflammatory and soothing effects of carboxymethyl deacetylated chitosan and water-soluble hydroxyphenylpropionamide benzoic acid.

[0029] In the above-mentioned soothing composition, water and a preservative are also included.

[0030] At the same time, the present invention also discloses the use of any of the above soothing compositions for preparing cosmetics.

[0031] In the above-mentioned use, the cosmetics are cosmetics that act on the skin; the cosmetics are essences, lotions, creams or facial masks.

[0032] Finally, the present invention also discloses a cosmetic comprising any of the above soothing compositions.

[0033] In the above-mentioned cosmetics, the amount of the soothing composition in the cosmetics is 1 to 5 wt %.

[0034] In the above-mentioned cosmetics, the cosmetics are cosmetics that act on the skin; the cosmetics are essences, lotions, creams or facial masks.

[0035] Beneficial Effects

[0036] The present invention discloses a soothing composition, which effectively exerts the synergistic soothing effect of carboxymethyl chitosan, water-soluble hydroxyphenylpropionamide benzoic acid and plant extracts, and significantly improves the soothing effect;

[0037] When the plant extract is compounded with Sophora japonica extract and Sage extract and the amount of Sophora japonica extract is larger, a better soothing effect can be achieved. DETAILED DESCRIPTION

[0038] The present invention will be further described below in conjunction with the embodiments, but it does not constitute any limitation to the present invention. Any limited number of modifications made within the scope of the claims of the present invention are still within the scope of the claims of the present invention.

[0039] In order to explain the technical content of the present invention in detail, further description is given below in conjunction with the implementation modes.

[0040] Reagent Source

[0041] Carboxymethyl chitosan: Zhongshan Haihong Pharmaceutical Co., Ltd., carboxymethyl chitosan;

[0042] Water-soluble hydroxyphenylpropionamide benzoic acid: Zhongshan Haihong Pharmaceutical Co., Ltd., water-soluble hydroxyphenylpropionamide benzoic acid;

[0043] Sophora japonica extract: Zhongshan Haihong Pharmaceutical Co., Ltd., Sophora japonica extract;

[0044] Sage extract: Zhongshan Haihong Pharmaceutical Co., Ltd., Sage extract;

[0045] Licorice extract: Zhongshan Haihong Pharmaceutical Co., Ltd., Licorice extract;

[0046] Centella asiatica extract: Zhongshan Haihong Pharmaceutical Co., Ltd., Centella asiatica extract;

[0047] Purslane extract: Zhongshan Haihong Pharmaceutical Co., Ltd., Purslane extract;

[0048] Gentiana extract: Zhongshan Haihong Pharmaceutical Co., Ltd., Gentiana root extract.

[0049] According to the results of computer simulation experiments, a total of 15 plant extracts were screened out that could potentially produce a soothing effect with carboxymethyl deacetylated chitosan and water-soluble hydroxyphenylpropionamide benzoic acid; after a preliminary analysis of the performance of several plant extracts, Sophora japonica extract, sage extract, licorice extract, Centella asiatica extract, Portulaca oleracea extract, and Gentiana scabra extract were selected as further screening objects for subsequent experiments.

[0050] Part I Screening of Plant Extracts

[0051] Carboxymethyl chitosan, water-soluble hydroxyphenyl propionamide benzoic acid and plant extract are mixed to form an aqueous solution. The preparation method is: carboxymethyl chitosan, water-soluble hydroxyphenyl propionamide benzoic acid and plant extract are added into distilled water, and stirred and dispersed evenly to form a uniform phase.

[0052] Its formula can be found in Table 1;

[0053] Table 1 Formula Unit: g

[0054]

[0055] The above aqueous solution was diluted 50 times and then the hyaluronidase inhibition rate was tested. The test method can be found below, and the test results can be found in Table 2;

[0056] Table 2 Hyaluronidase inhibition rate test results Unit: %

[0057]

[0058] The above tests show that Sophora japonica extract, Gentiana dahurica extract, Centella asiatica extract, Sage extract and Portulaca oleracea extract have relatively obvious soothing effects.

[0059] Part II Composition Optimization Experiment

[0060] It can be seen from the experiment in the first part above that the addition of the above plant extracts can effectively enhance and improve the soothing effect of carboxymethyl deacetylated chitosan and water-soluble hydroxyphenyl propionamide benzoic acid. In subsequent experiments, it is further verified whether the above preferred plant ingredients can achieve a better effect by compounding. The specific preparation method refers to the first part, and the formula refers to Table 3;

[0061] Table 3 Formula table Unit: g

[0062]

[0063]

[0064] The above aqueous solution was diluted 50 times and then the hyaluronidase inhibition rate was tested. The test method can be found below, and the test results can be found in Table 4;

[0065] Table 4 Hyaluronidase inhibition rate test results Unit: %

[0066]

[0067] The above tests show that there is a possibility of functional synergy between Sophora japonica extract and Sage extract, while theoretically there is no functional synergy between Sophora japonica extract and Centella asiatica extract, Portulaca oleracea extract and Gentiana scabra extract.

[0068] Part III Functional verification of Sophora japonica extract and Sage extract

[0069] Through the experiment in the second part above, it can be seen that there is a possibility of soothing synergy between Sophora japonica extract and Sage extract. In order to further verify the relationship between the two, the dosage of the two was adjusted. The specific preparation method refers to the first part, and the formula refers to Table 5;

[0070] Table 5 Formula table Unit: g

[0071]

[0072] The above aqueous solution was diluted 50 times and then the hyaluronidase inhibition rate was tested. The test method can be found below, and the test results can be found in Table 6;

[0073] Table 6 Hyaluronidase inhibition rate test results Unit: %

[0074]

[0075]

[0076] It can be seen from the above Examples 8, 12 to 15 that when the ratio of Sophora japonica extract to Sage extract exceeds 3:5, the soothing performance of the formula is enhanced;

[0077] It can be seen from Examples 8, 16 and 17 that the dosage of carboxymethyl deacetylated chitosan and water-soluble hydroxyphenylpropionamide benzoic acid does not have a decisive influence on the soothing performance. However, in the preliminary study of this project, it was found that when the dosage of the two is less than 1%, the soothing performance will be significantly weakened.

[0078] Hyaluronidase inhibition rate detection method

[0079] Negative control: a mixture of 2.2 wt% 1,2-hexanediol, 70 wt% 1,3-butanediol and pure water.

[0080] Test operation steps

[0081] Set up a sample group, a sample background group, a solvent group and a solvent background group. Each group needs to have 3 parallels. Add different reagent solutions to the four groups respectively, shake well, and leave at room temperature for 30 minutes for color development. Use a UV spectrophotometer to measure the absorbance value at a wavelength of 528nm.

[0082] The calculation formula is as follows: {1-(CD) / (AB)}*100%;

[0083] Where: A—is the absorbance of the reaction solution without sample;

[0084] B—is the absorbance of the reaction solution without sample and enzyme;

[0085] C—is the absorbance of the reaction solution containing sample and enzyme;

[0086] D—is the absorbance of the reaction solution containing sample and without enzyme.

[0087] Part 4 Application Formulation

[0088] The present invention can be applied to water solution, essence, and cream; the formula is as follows:

[0089] 1. Aqueous solution: water, glycerin, butylene glycol, 2% of combined raw materials, cinnamaldehyde, hexylene glycol

[0090] 2. Essence: water, glycerin, butylene glycol, carbomer 941, TEA, 2% of combined raw materials, cinnamaldehyde, hexylene glycol

[0091] 3. Cream: water, glycerin, butylene glycol, carbomer U20, M68, A165, 16 / 18 alcohol, GTCC, 2EHP, DC200 / 350, TEA, combined raw materials 2%, cinnamaldehyde, hexylene glycol.

[0092] The embodiments presented herein are only embodiments selected according to the combination of all possible embodiments. The appended claims should not be limited by the embodiments describing the present invention. Some numerical ranges used in the claims include sub-ranges therein, and the changes in these ranges should also be covered by the appended claims.

Claims

1. A soothing composition, characterized in that The invention comprises carboxymethyl chitosan, water-soluble hydroxyphenyl propionamide benzoic acid and plant extracts, wherein the plant extracts are Sophora japonica extracts and / or Sage extracts; The weight ratio of the carboxymethyl chitosan, the water-soluble hydroxyphenylpropionamide benzoic acid and the plant extract is 2-5:2-5:4-10.

2. The soothing composition according to claim 1, characterized in that The weight ratio of the carboxymethyl chitosan, the water-soluble hydroxyphenylpropionamide benzoic acid and the plant extract is 2-4:2-4:5-9.

3. The soothing composition according to claim 1, characterized in that The weight ratio of the carboxymethyl chitosan, the water-soluble hydroxyphenylpropionamide benzoic acid and the plant extract is 2-3:2-3:5-8.

4. The soothing composition according to claim 1, characterized in that The plant extracts are Sophora japonica extract and Sage extract; The weight ratio of the Sophora japonica extract to the Sage extract is 3-7:1-3.

5. The soothing composition according to any one of claims 1 to 4, characterized in that: Also includes water and preservatives.

6. Use of the soothing composition according to any one of claims 1 to 5 in preparing cosmetics.

7. The use according to claim 6, characterized in that The cosmetics are cosmetics that act on the skin; the cosmetics are essences, lotions, creams or facial masks.

8. A cosmetic, characterized in that: Contains the soothing composition according to any one of claims 1 to 5.

9. The cosmetic according to claim 8, characterized in that: The soothing composition is used in an amount of 1 to 5 wt % in the cosmetic.

10. The cosmetic according to claim 8, characterized in that: The cosmetics are cosmetics that act on the skin; the cosmetics are essences, lotions, creams or facial masks.

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